Front. Immunol. Frontiers in Immunology Front. Immunol. 1664-3224 Frontiers Media S.A. 10.3389/fimmu.2024.1476204 Immunology Correction Corrigendum: Genetic investigation of Nordic patients with complement-mediated kidney diseases Rydberg Viktor Aradottir Sigridur Sunna Kristoffersson Ann-Charlotte Svitacheva Naila Karpman Diana * Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden

Edited and Reviewed by: Francesca Granucci, University of Milano-Bicocca, Italy

*Correspondence: Diana Karpman, diana.karpman@med.lu.se

23 08 2024 2024 15 1476204 05 08 2024 08 08 2024 Copyright © 2024 Rydberg, Aradottir, Kristoffersson, Svitacheva and Karpman 2024 Rydberg, Aradottir, Kristoffersson, Svitacheva and Karpman

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 A Corrigendum on Genetic investigation of Nordic patients with complement-mediated kidney diseases By Rydberg V, Aradottir SS, Kristoffersson A-C, Svitacheva N and Karpman D (2023). Front. Immunol. 14:1254759. doi: 10.3389/fimmu.2023.1254759 complement atypical hemolytic uremic syndrome C3 glomerulopathy membranoproliferative glomerulonephritis genes section-in-acceptance Molecular Innate Immunity

In the published article, there was an error in Table 3 as published. Under the heading C3, rowc.4030-4C>G was under the ACMG classification stated as “P” when it should be “LB”. Under the heading CFHR2, row R141S, “c.423G>A” should have been written as “c.423G>T”. And finally, under the heading CLU, row K444Q, “c.1339A>C” should be corrected to “c.1330A>C”. The corrected Table 3 and its caption appear below.

Variants in C3G patients included in this study.

Variant or deletion Nucleotide shift Type of variant dbSNP Domain Minor Allele frequency Functional studies ACMG classification Reference
CFH
D693N a c.2077G>A Missense rs148403790 SCR12 0.0001592 Conflicting (48)
Q950H c.2850G>T Missense rs149474608 SCR16 0.003911 NPE LP (45, 51)
N1050Yb c.3148A>T Missense rs35274867 SCR18 0.01469 NPE LB (45, 54)
S1209T c.3625T>A Missense rs561146868 SCR20 0.00000398 – LB (48)
C3
K155Q c.463A>C Missense rs147859257 MG2 0.002705 GoF LP (58, 59)
V326Mc c.976G>A Missense rs375264020 MG3 0.00004779 – VUS This study
Q1061H c.3183A>T Missense rs373054812 TED 0.00007704 – VUS This study
E1516A c.4547A>C Missense rs1019532370 C345C 0.00001193 – VUS This study
W1631* c.4893G>A Stop NA C345C – LoF P (61)
c.4030-4C>G Splice acceptor site NA Between CUB and MG8 – – LB (55)
CFI
c.1534+5G>T Intronic splice rs114013791 Intron 12 0.00866 – – (33)
G328R c.981G>A Missense rs144164794 Linker 2 – LoF LP (55, 65)
CD46
A353Va,b c.1013C>T Missense rs35366573 TM 0.01541 LoF, NFE Conflicting (33, 73)
C5
P233L c.698C>T Missense rs531284110 MG3 0.0000252 – VUS (81)
L354M c.1060C>A Missense rs34552775 MG4 0.0055 – B (82)
G385R c.1153G>C Missense – MG4 Unknown – – This study
CFHR1
Deletion Deletion – – LB (76)
Exon 6 duplication Duplication – LB This study. Other duplications reported in (83)
CFHR2
R141S c.423G>T Missense rs142929868 SCR2 0.002947 – – This study
CFHR3
Deletion Deletion – – – (76)
CFHR4
Y43Fd c.128A>T Missense rs202234955 SCR1 0.001747 – LB This study
c.799+3A>C Intronic splice Rs196876631 – 0.001286 – LB (82)
CFHR5
E163Kfs*10 c.485_486dup Frameshift (insertion) rs565457964 SCR3 0.006750 NPE – (77)
E226Dfs*7 c.678del Deletion rs1438537910 SCR4 0.000007964 – P This study
Y279N c.835T>A Missense rs143240067 SCR5 0.0001274 – Conflicting (78)
R356Hb c.1067G>A Missense rs35662416 SCR6 0.01633 NPE LB (77, 84)
CFP
D299N c.895G>A Missense rs61737993 TSP t1 5 0.001472 – B (85)
CLU
K444Q c.1330A>C Missense rs2612311022 β-chain 0.0001026 - - This study
PLG
R89K c.266G>A Missense rs143079629 PAN 0.006191 – B (48)
R261H c.782G>A Missense rs4252187 Kringle 2 0.002501 – Conflicting (80)

a, Mentioned in the complement database (www.complement-db.org) with reference to (4). b, Minor allele frequency > 1% but this variant was previously associated with aHUS. c, Previously reported in the ClinVar database in association with age-related macular degeneration and aHUS. d, Previously reported in the ClinVar database in association with aHUS. CFH, Complement factor H; C3, Complement C3; CFB, Complement factor B; CFI, Complement factor I; CD46, CD46/Membrane cofactor protein; C5, Complement C5; CFHR1-5, Complement factor H related 1-5; CFP, Complement factor properdin; PLG, Plasminogen. Domains, SCR, Short consensus repeats; MG1-8, Macroglobulin domain 1-8; TED, Thiol ester-containing domain; C345C, C345C/NTR domain; CUB: C1r/C1s, Urchin embryonic growth factor, Bone morphogenetic protein 1; TM, Transmembrane protein; TSP t1, Thrombospondin type-1 1-5; PAN, Plasminogen-Apple-Nematode; NPE, No phenotypic effect; GoF, Gain of function; LOF, Loss of function (including low plasma concentration); VUS, Variant of unknown significance; LP, Likely pathogenic; LB, Likely benign; P, Pathogenic.

In the published article, there was an error in Supplementary Table 1. The C3 level of patient 314 was given as “normal” when it should have been written as “low”. The corrected Supplementary Material File has now been published.

The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.

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