AUTHOR=Wu Shouhai , Rong Cuiping , Lin Ruishan , Ji Kaiyuan , Lin Tongxiang , Chen Weimin , Mao Wei , Xu Yang 

TITLE=Chinese medicine PaBing-II protects human iPSC-derived dopaminergic neurons from oxidative stress

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1410784

DOI=10.3389/fimmu.2024.1410784

ISSN=1664-3224

ABSTRACT=PaBing-II Formula (PB-II) is a traditional Chinese medicine for treating Parkinson's disease (PD). To investigate the mechanisms underlying the therapeutic benefits of PB-II in patients with PD, we developed human dopaminergic neurons (DAn) oxidative damage models by treating human induced pluripotent stem cells (hiPSCs) derived DAn with H2O2 as well as the 6-hydroxydopamine (6-OHDA)-induced PD rat model. Through in vitro and in vivo studies, we demonstrate that PB-II significantly protects DAn from oxidative stress and inflammation via Nrf2 pathway activation, and is manifested as a treatment for Parkinson's disease.