AUTHOR=Korkmaz H. Ibrahim , Sheraton Vivek M. , Bumbuc Roland V. , Li Meifang , Pijpe Anouk , Mulder Patrick P. G. , Boekema Bouke K. H. L. , de Jong Evelien , Papendorp Stephan G. F. , Brands Ruud , Middelkoop Esther , Sloot Peter M. A. , van Zuijlen Paul P. M. 

TITLE=An in silico modeling approach to understanding the dynamics of the post-burn immune response

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1303776

DOI=10.3389/fimmu.2024.1303776

ISSN=1664-3224

ABSTRACT=Predicting the dynamics of wound healing process can be challenging for burn injuries. We present simulation models for the post-burn immune response based on (pre)clinical data. We developed an Glazier-Graner-Hogeweg method-based model (GGH) to capture the complexities associated with the dynamics of inflammation after burn injuries, including changes in cell counts and cytokine levels. Through simulations from day 0 -4 post-burn, we successfully identified key factors influencing the acute inflammatory response, i.e., the initial number of endothelial cells, the chemotaxis threshold, and the level of chemoattractants. Our findings highlight the pivotal role of the initial cell count regarding the intensity of inflammation and the timeline of acute inflammation, 0 -4 days post-burn.