AUTHOR=Yong Jiaxin , Cai Songqing , Zeng Zhaolei 

TITLE=Targeting NAD+ metabolism: dual roles in cancer treatment

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1269896

DOI=10.3389/fimmu.2023.1269896

ISSN=1664-3224

ABSTRACT=Nicotinamide adenine dinucleotide (NAD + ) is indispensable for various oxidationreduction reactions in mammalian cells, particularly during energy production. Malignant cells increase the expression levels of NAD + biosynthesis enzymes for rapid proliferation and biomass production. Furthermore, mounting proof has indicated that NAD-degrading enzymes (NADases) play a role in creating the immunosuppressive tumor microenvironment (TME). Interestingly, both inhibiting NAD + synthesis and targeting NADase have positive implications for cancer treatment. Here we summarize the detrimental outcomes of increased NAD + production, the functions of NAD + metabolic enzymes in creating an immunosuppressive TME, and discuss the progress and clinical translational potential of inhibitors for NAD + synthesis and therapies targeting NADase.