AUTHOR=Kammala Ananth Kumar , Mosebarger Angela , Radnaa Enkhtuya , Rowlinson Emma , Vora Natasha , Fortunato Stephen J. , Sharma Surendra , Safarzadeh Melody , Menon Ramkumar 

TITLE=Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1196453

DOI=10.3389/fimmu.2023.1196453

ISSN=1664-3224

ABSTRACT=barriers to delay E. coli-induced PTB to deliver live pups at term. Delay in PTB was associated with reduced feto-maternal uterine inflammation (immune cell infiltration and histologic chorioamnionitis, NF-κB activation, and proinflammatory cytokine production).CONCLUSIONS: eIL-10 administration was safe, stable, specific, delayed PTB by over 72 hrs and delivered live pups. The delivery of drugs using EVs overcomes the limitations of in-utero fetal interventions. Protecting IL-10 in EVs eliminates the need for the amniotic administration of recombinant IL-10 for its efficacy.