AUTHOR=Ma Zhuoying , Chen Lin , Xian Ruoling , Fang Heping , Chen Jing , Li Haiqi , Wang Juan , Hu Yan 
  
TITLE=Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years
  
JOURNAL=Frontiers in Immunology
  
VOLUME=Volume 14 - 2023
  
YEAR=2023
  
URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1153607
  
DOI=10.3389/fimmu.2023.1153607
  
ISSN=1664-3224
  
ABSTRACT=Background: Although epidemiological trends of childhood food sensitization (FS) in IgE-mediated food allergy were reported in China, few studies have looked at changes in its risk factors. 
Objective: To investigate the change in early-life risk factors associated with childhood food sensitization during 2009–2019 in China.
Methods: Data from two cross-sectional surveys conducted in 2009 and 2019 (401 and 513 children, respectively) were analyzed. The results of skin prick tests and information on food sensitization-related risk factors in children were summarized, including family history of atopic disease (FHA), demographic characteristics, method of delivery, feeding patterns, sibship size, pet ownership, and vitamin D supplementation. Binary logistic regression was used to calculate the odds ratio and the regression coefficient β-value of risk factors in 2009 and 2019 surveys separately. Then coefficient β-value differences between the two surveys were analyzed by bdiff command in STATA to describe the change in risk factors over 10 years.. 
Results: The 2009 survey revealed that FHA, age, only-child, and feeding patterns were associated with food sensitization. The 2019 survey showed that food sensitization was affected by age, sex, and feeding patterns. However, from 2009 to 2019, the probability of food sensitization in the only-child group significantly increased by 226.0% (β-value difference = 0.81, P = 0.024) and decreased by 65.0% in females (β-value difference = −1.06, P = 0.008). The effect of age on food sensitization decreased by 50.0% (β-value difference = −0.69, P < 0.001) over 10 years. 
Conclusion: The effect of FHA and common lifestyle factors on food sensitization did not significantly change during 2009−2019. However, the influence of demographic characteristics on food sensitization has changed since 2009, that is, older age, males, and only-child are more likely to develop food sensitization, which needs to be considered in future epidemiological surveys.