AUTHOR=Ma Ling , Feng Yanmin , Zhou Zishan 

TITLE=A close look at current γδ T-cell immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1140623

DOI=10.3389/fimmu.2023.1140623

ISSN=1664-3224

ABSTRACT=Due to their antitumor and MHC-independent capacities, γδ T cells have gained popularity in adoptive T cell immunotherapy in recent years.  However, many unknowns still exist regarding γδ T cells, and not much clinical data has been conducted.  Therefore, this review aims to cover all the main features of the applications of γδ T cells in different aspects and provide a systematic view of current γδ T cell immunotherapy. Specifically, this review will focus on how γδ T cells were performed in treating cancers in clinics, the γδ T cell clinical trials that have been conducted to date, and the role of γδ T cells in the industry.