AUTHOR=Dong Ying , Yao Jianling , Deng Qingyue , Li Xianxian , He Yingyu , Ren Xueyang , Zheng Yuan , Song Ruolan , Zhong Xiangjian , Ma Jiamu , Shan Dongjie , Lv Fang , Wang Xiuhuan , Yuan Ruijuan , She Gaimei 

TITLE=Relationship between gut microbiota and rheumatoid arthritis: A bibliometric analysis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1131933

DOI=10.3389/fimmu.2023.1131933

ISSN=1664-3224

ABSTRACT=Rheumatoid arthritis (RA) is a multifactorial autoimmune disease. Recently, growing evidence demonstrates that gut microbiota (GM) plays an important role in RA. In this study, 255 original research articles and 204 reviews related to the involvement of GM in RA were searched and picked from the Web of Science Core Collection (WOSCC) database, which is used to analyze the annual output, cooperation, hotspots, research status and development trend of this field by bibliometric software (VOSviewer and Bibliometricx). The articles in this field that can be retrieved in WOSCC were first published in 2004 and increased year by year since then. 2013 is a growth explosion point. China and the United States are the countries with the most contributions, and Harvard University is the affiliation with the most output. Frontiers in Immunology (total citations = 603) is the journal with the most publications and the fastest growth rate. eLife is the journal with the most citations (total citations = 1248). Scher, Jose U. and Taneja, Veena are the most productive and cited authors. The research in this field is mainly distributed in the evidence, mechanism and practical application of GM participating in RA through the analysis of keywords and documents. There is sufficient evidence to prove the close relationship between GM and RA, which lays the foundation for this field. This extended two colorful and tender branches of mechanism research and application exploration, which have made some achievements but still have broad exploration space. Recently, the keywords “metabolites”, “metabolomics”, ‘acid’, “b cells”, “balance”, “treg cells”, “probiotic supplementation” appeared most frequently, which tells us that research on the mechanism of GM participating in RA and exploration of its application are the hotspots in recent years. This bibliometric study can provide a data-based and objective introduction to the GM participating in RA, and give readers a valuable reference to help guide future research.