AUTHOR=Plum Lori A. , Blaser William , Peter Logan , Prahl Jean , Seeman Jeremy , DeLuca Hector F. 

TITLE=Antibody production in mice requires neither vitamin D, nor the vitamin D receptor

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.960405

DOI=10.3389/fimmu.2022.960405

ISSN=1664-3224

ABSTRACT=The idea that vitamin D plays a significant role in immunity has been proposed repeatedly for many years. To address this important idea we have carried out studies in mice to determine if vitamin D plays a significant role in antibody production. Two animal models were utilized: mice depleted of vitamin D and mice devoid of the vitamin D receptor.  Further, a possible role of hypocalcemia resulting from vitamin D deficiency in antibody production was determined.  Neither the absence of vitamin D or the vitamin D receptor nor hypocalcemia affected the ability of mice to mount an antibody response to an antigen challenge. Thus, we found no evidence that vitamin D or normal serum calcium is required for this major form of immunity.