AUTHOR=Xie Yan , Liu Yang , Liu Yi 

TITLE=The Flare of Rheumatic Disease After SARS-CoV-2 Vaccination: A Review

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.919979

DOI=10.3389/fimmu.2022.919979

ISSN=1664-3224

ABSTRACT=As the coronavirus disease 2019 (COVID-19) pandemic continues, rheumatic disease (RD) patients are strongly recommended to receive vaccination against the acute respiratory syndrome coronavirus 2（SARS-CoV-2）due to the increased risk of infection and more severe outcomes of COVID-19 in these patients. However, concern for the induction of RD flare may combat the enthusiasm for vaccination. For RD patients, current pieces of evidence don’t support for increased risk of disease flare after COVID-19 vaccination. However, the disease flare of RDs may be triggered by COVID-19 vaccination, especially for patients with high disease activity. Most of these flares after vaccination are mild and need no treatment escalation. Considering the benefit and risks, RD patients are recommended to receive the COVID-19 vaccination but should be vaccinated when the RDs are in a stable state.