Front. Immunol. Frontiers in Immunology Front. Immunol. 1664-3224 Frontiers Media S.A. 10.3389/fimmu.2022.1125497 Immunology Erratum Erratum: Type 1 regulatory T cell-mediated tolerance in health and disease Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland

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 An Erratum on Type 1 regulatory T cell-mediated tolerance in health and disease By Freeborn RA, Strubbe S and Roncarolo MG (2022) Front. Immunol. 13:1032575. doi: 10.3389/fimmu.2022.1032575 type 1 regulatory T (Tr1) cells immunological tolerance autoimmunity inflammatory bowel disease infectious disease

Due to a production error, there was a mistake in Table 1 as published. Some of the citations in Table 1 did not link to the correct references in the reference list. The corrected Table 1 appears below. The publisher apologizes for this mistake.

Overview of the role of Tr1 and IL-10-producing CD4+ T cells in AIDs and IBD.

Disease Cell identity Model Major finding Reference
T1D FOXP3- IL-10-producing CD4+ T cells NOD BDC2.5 TCR-transgenic and NOD/SCID mice Intestinal FOXP3- IL-10-producing CD4+ T cells can protect from T1D 76
IL-10-producing CD4+ T cells NOD and NOD/SCID mice Combination of rapamycin and IL-10 reduces incidence of diabetes 77
GAD65-specific IL-10-producing CD4+ T cells GAD65-immunized NOD and NOD/SCID mice Protection from T1D in adoptive transfer experiments 78
Antigen-specific IL-10-producing CD4+ T cells Immunized NOD and NOD/SCID mice Antigen-containing PLG nanoparticles protect from T1D 79
CD49b+LAG-3+ Tr1 cells Immunized NOD and NOD/SCID mice IGRP- and 2.5mi/IAg7 nanoparticles expand pre-existing Tr1 cells and protect from T1D 80
Islet-specific IL-10-producing CD4+ T cells Patient PBMCs Higher frequency in healthy donors 81
Islet-specific IL-10-producing CD4+ T cells Patient PBMCs Higher frequency in first degree relatives 82
Insulin-specific IL-10-producing CD4+ T cells Patient PBMCs Higher in patients that have better future glucose control 83
IGFR-specific IL-10-producing CD4+ T cells Patient PBMCs Higher frequency in juvenile T1D compared to adult T1D 84
IL-10-producing CD4+ T cells Patient PBMCs Increase in IL-10-producing CD4+ T cells upon anti-CD3 treatment 85
Proinsulin-specific IL-10-producing CD4+ T cells Proinsulin-immunized patient PBMCs Increase in IL-10 production and decrease in insulin dependency 86
IGRP-specific CD49b+LAG-3+ Tr1 cells IGRP-immunized NSG mice reconstituted with DR4 patient PBMCs Induction of IGRP-specific CD49b+LAG-3+ Tr1 cells 80
MS OVA-specific IL-10-producing CD4+ T cells OVA-immunized MSCH-induced EAE mice OVA-specific protection from EAE development 87
IL-10-producing CD4+ T cells MOG-induced EAE mice IL27-pulsed DCs upregulate IL-10 production by CD4+ T cells for protection from EAE development 88
CD49b+LAG-3+ Tr1 cells MOG-induced EAE mice Protection from EAE development independently of IL-10 89
IL-10-producing CD4+ T cells MOG-induced EAE mice Melatonin induces IL-10-producing CD4+ T cells to protect from EAE development 65
CD49b+LAG-3+ Tr1 cells PLP-induced EAE mice PLP- and MOG-containing pMHCII nanoparticles protect from EAE development 80
IL-10-producing CD4+ T cells PLP- and MOG-induced EAE MOG- and AhR-containing NLPs protects from EAE development 90
CD46-induced IL-10-producing CD4+ T cells Patient PBMCs Lower frequency in MS patients 91
CD46-induced IL-10-producing CD4+ T cells Patient PBMCs Altered glycosylation of CD46 in MS patients 57
SLE CD46-induced IL-10-producing CD4+ T cells Patient PBMCs Lower frequency in SLE patients 24
IL-10-producing IL7R- CD4+ T cells Patient PBMCs Decreased ability in limiting autoantibody production by B cells 16
IL-10-producing CXCR5-CXCR3+PD-1high CD4+ T cells Patient PBMCs CXCR5-CXCR3+PD-1high CD4+ T cell-derived IL-10 can stimulate autoantibody production 92
Arthritis Collagen type II-specific IL-10-producing CD4+ T cells Collagen type II-immunized DBA/1 mice Protection from arthritis development 93
Psoriasis CD49b+LAG-3+ Tr1 cells Patient PBMCs and skin biopsies Presence of Tr1 cells inversely correlated with disease severity 94
Celiac disease Gliadin-specific IL-10-producing CD4+ T cells Patient intestinal T cells Gliadin-specific suppression of effector T cells 44
Gliadin-specific IL-10-producing CD4+ T cells Patient PBMCs and intestinal T cells Multi-epitope gliadin extract induces tolerance in celiac disease patients 95
IBD OVA-specific IL-10-producing CD4+ T cells CD4+CD45RBhigh adoptive transfer mice Prevention of colitis in recipient mice 4
IL10-deficient CD4+CD45RBlow T cells CD4+CD45RBhigh adoptive transfer mice Protection from colitis is dependent on IL-10 96
IL-10-producing CD4+ T cells CD4+CD45RBhigh adoptive transfer mice Prevention of Th17-mediated colitis 97
IL-10-producing CD4+ T cells DSS-induced colitis mouse model GSK-J4-mediated induction of tolerogenic DCs to promote IL-10 production by CD4+ T cells 98
IL-10-producing CD44+CD4+ T cells TNBS-induced colitis mouse model MSCs induce expansion of IL-10-producing CD44+CD4+ T cells 99
Intestinal IL7R-CCR5+PD-1+ Tr1 cells Patient intestinal T cells Decreased IL-10 production 30
IL-10-producing OVA-Treg Patient PBMCs Amelioration of disease in treated patients 100
CD49b+LAG-3+ Tr1 cells Patient PBMCs and colon biopsies Decrease of myeloid-derived inflammatory cytokines and production of IL-22 and mucin to promote barrier integrity 69

The original version of this article has been updated.

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