AUTHOR=Chapelle Nicolas , Fantou Aurelie , Marron Thomas , Kenigsberg Ephraim , Merad Miriam , Martin Jerome C. 

TITLE=Single-cell profiling to transform immunotherapy usage and target discovery in immune-mediated inflammatory diseases

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1006944

DOI=10.3389/fimmu.2022.1006944

ISSN=1664-3224

ABSTRACT=Immunotherapy drugs are transforming the clinical care landscape leading to a surge for the identification of novel immune targets of major human diseases from cancer, to inflammatory diseases, cardiovascular diseases, neurodegenerative diseases and even aging. Yet most FDA-approved drugs target known pathophysiological pathways for which medicine are already available. This reflects a common struggle to identify novel and relevant molecular drivers of disease that stems from a suboptimal understanding of human disease pathophysiology and crisp knowledge of target expression profile during disease course. Here we discuss the potential for single-cell technologies to reveal relevant pathogenic cellular programs in human diseases and to enhance drug development strategies and clinical trial design.