Front. Immunol.Frontiers in ImmunologyFront. Immunol.1664-3224Frontiers Media S.A.10.3389/fimmu.2021.765892ImmunologyCorrectionCorrigendum: CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in MiceOladiranOladayo1ShiXiang Qun1FournierSylvie2*ZhangJi1234*1The Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada2Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada3Department of Neurology & Neurosurgery, McGill University, Montreal, QC, Canada4Faculty of Dentistry, McGill University, Montreal, QC, Canada
Edited and reviewed by: Thiago Mattar Cunha, University of São Paulo, Brazil
*Correspondence: Ji Zhang, Ji.Zhang@mcgill.ca; Sylvie Fournier, Sylvie.Fournier@mcgill.ca
This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology
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A Corrigendum on CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice Oladiran O, Shi XQ, Fournier S and Zhang J (2021). Front. Immunol. 12:720733. doi: 10.3389/fimmu.2021.720733macrophagesCD8+ T cellsautoimmune peripheral neuropathyCX3CR1CCR2apoptosisphagocytosis
In the original article, there was a mistake in Figure 6 as published. The wrong representative FACS plot was inserted for L31/CCR2KO in Figure 6A. The corrected Figure 6 appears below.
The impact of CX3CR1 and CCR2 deficiency on monocyte/macrophage and CD8+ T cells survival and function in L31 mice. (A) Representative flow cytometry plot and quantitative analysis of monocytes apoptosis. Compared to L31 and L31/CCR2KO mice, increased monocyte death was observed in the blood of L31/CX3CR1KO mice. (B) Similar level of cell proliferation was seen in L31 and L31/CX3CR1KO mice, indicating that no enhanced proliferation occurred to compensate the increased cell death. Monocyte cell proliferation was barely detectable in L31/CCR2KO mice. (C) CD8+ T cells apoptosis (Annexin V+/7-AAD-) was observed essentially in L31/CX3CR1KO mice. (D) The majority of apoptotic CD8+ T cells were of the activated phenotype (CD44+CD43+). (E) Proliferation of CD8+ T cells was similar in all three groups, L31, L31/CX3CR1KO and L31/CCR2KO mice, showing no enhanced proliferation to compensate for CD8+ T cell death in L31/CX3CR1KO mice. (F) Macrophage proliferation was strongly enhanced in L31/CCR2KO mice, 87% (Ki67+ cells over total nerve macrophages (F4/80CD11b) in L31/CCR2KO mice and 58% in L31 mice. (G) mean fluorescent intensity (MFI) depicts the amount of phagocytosed beads by nerve macrophages. The highest MFI was observed in L31and L31/CCR2KO mice, which was significantly reduced in L31/CX3CR1KO mice. Quantification in A-E depicted the number of cells per µl blood. Quantification in F depicted the number of cells per a segment of 2 cm long sciatic nerve. Disease was induced by PSNL, and experiments done 30 days post PSNL. n=5-6/group; student’s t test; *p < 0.05; **p < 0.01; ***p < 0.001.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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