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<article article-type="review-article" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xml:lang="EN"><?covid-19-tdm?>
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Glob. Womens Health</journal-id>
<journal-title>Frontiers in Global Women's Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Glob. Womens Health</abbrev-journal-title>
<issn pub-type="epub">2673-5059</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fgwh.2023.1132768</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Global Women's Health</subject>
<subj-group>
<subject>Systematic Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Impact of COVID-19 stress on the psychological health of sexual &#x0026; gender minority individuals: A systematic review</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><name><surname>Datta</surname><given-names>Sumona</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref><uri xlink:href="https://loop.frontiersin.org/people/1656784/overview"/></contrib>
<contrib contrib-type="author"><name><surname>Mukherjee</surname><given-names>Tilottama</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/269208/overview"/></contrib>
</contrib-group>
<aff id="aff1"><label><sup>1</sup></label><addr-line>Department of Psychology</addr-line>, <institution>Government General Degree College</institution>, <addr-line>Singur</addr-line>, <country>Hooghly, India</country></aff>
<aff id="aff2"><label><sup>2</sup></label><addr-line>Department of Psychology</addr-line>, <institution>University of Calcutta</institution>, <addr-line>Kolkata</addr-line>, India</aff>
<author-notes>
<fn fn-type="edited-by"><p><bold>Edited by:</bold> Maureen Edwards, Montgomery College, United States</p></fn>
<fn fn-type="edited-by"><p><bold>Reviewed by:</bold> Kelly Melekis, University of Vermont, United States Swapnajeet Sahoo, Post Graduate Institute of Medical Education and Research (PGIMER), India</p></fn>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> Sumona Datta <email>sumonadatta.psych@gmail.com</email></corresp>
<fn fn-type="other" id="fn001"><p><bold>Specialty Section:</bold> This article was submitted to Women&#x2019;s Mental Health, a section of the journal Frontiers in Global Women&#x2019;s Health</p></fn>
</author-notes>
<pub-date pub-type="epub"><day>29</day><month>03</month><year>2023</year></pub-date>
<pub-date pub-type="collection"><year>2023</year></pub-date>
<volume>4</volume><elocation-id>1132768</elocation-id>
<history>
<date date-type="received"><day>27</day><month>12</month><year>2022</year></date>
<date date-type="accepted"><day>28</day><month>02</month><year>2023</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2023 Datta and Mukherjee.</copyright-statement>
<copyright-year>2023</copyright-year><copyright-holder>Datta and Mukherjee</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract><sec><title>Introduction</title>
<p>The differential effect of the Covid-19 pandemic on the mental health of the population around the globe is well documented. Social isolation, loss of job, financial crisis, and fear of infection due to the pandemic have widely affected people across countries, and the sexual and gender minority (SGM) group is no exception. However, the additional stressors like stigma, discrimination, rejection, non-acceptance, and violence associated with diverse sexual orientation complicated the situation for the SGM group in the context of the Covid-19 pandemic.</p>
</sec><sec><title>Method</title>
<p>The present study conducted a systematic review of research (<italic>n&#x2009;</italic>&#x003D;&#x2009;16) investigating the impact of Covid-19 stress on the psychological health of SGM individuals. The review had two objectives: (a) to explore the effect of the stress associated with the pandemic on the psychological health of the SGM individuals; and (b) to identify potential stressors associated with the Covid-19 pandemic affecting the mental health of SGM individuals. Studies were selected following a PRISMA protocol and several inclusion criteria.</p>
</sec><sec><title>Results</title>
<p>The review provided new insights into the mental health issues of the SGM individual in the Covid-19 context. The outcome of the review focused on five aspects: (a) depression and anxiety symptoms related to Covid-19 symptoms; (b) perceived social support and Covid-19 stress; (c) family support and psychological distress related to Covid-19; (d) Covid-19 stress and disordered eating, and (e) problem drinking and substance abuse associated with Covid-19 stress.</p>
</sec><sec><title>Discussion</title>
<p>The present review indicated a negative association between Covid-19 stress and psychological distress among sexual and gender minority individuals. The findings have important implications for psychologists and social workers working with this population and policymakers around the globe.</p>
</sec>
</abstract>
<kwd-group>
<kwd>Sexual and gender minority (LGBTQ) populations issues</kwd>
<kwd>LGBTQ&#x002B;</kwd>
<kwd>depression</kwd>
<kwd>anxiety</kwd>
<kwd>COVID-19 pandemic</kwd>
<kwd>stress</kwd>
</kwd-group><counts>
<fig-count count="1"/>
<table-count count="2"/><equation-count count="0"/><ref-count count="92"/><page-count count="0"/><word-count count="0"/></counts>
</article-meta>
</front>
<body><sec id="s1" sec-type="intro"><title>Introduction</title>
<p>The incidence of Covid-19 in the past couple of years caused immense damage to the physical and mental health of people around the globe (<xref ref-type="bibr" rid="B1">1</xref>&#x2013;<xref ref-type="bibr" rid="B4">4</xref>). With subsequent waves of the mutant version of the virus, millions of people suffered, and thousands were dead (<xref ref-type="bibr" rid="B5">5</xref>&#x2013;<xref ref-type="bibr" rid="B8">8</xref>). The existence of co-morbid physical conditions like cardiac problems, diabetes, cancer, etc. proved to be fatal in most cases. In this mayhem, the marginalized communities suffered significantly under such circumstances, with lessened healthcare delivery and limited social security (<xref ref-type="bibr" rid="B9">9</xref>). The lesbian, gay, bisexual, transgender, and queer (LGBTQ) community is one of those marginalized groups that suffered immensely.</p>
<p>To reduce the spread of infection, every government imposed lockdowns, social distancing, quarantine, and banned travel around the world (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B11">11</xref>). Although the Covid virus affected people around the globe in a similar way, the outcomes were felt differently across some sections of the society, specifically for the SGM population, the reason being a profound level of social discrimination faced by these individuals across different cultures and societies (<xref ref-type="bibr" rid="B10">10</xref>). Moreover, studies reported that many of them have co-morbid conditions of HIV, Cancer, and other forms of physical conditions, which increased their difficulties instead (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B13">13</xref>). Lockdown and quarantine situations also inhibited them from going to their workplace, which in certain cases, serves as an escape for them, especially in low-income countries of Asia and Africa (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B14">14</xref>). Hence, the overall situation during the pandemic undoubtedly put them at a higher risk of physical and psychological turmoil.</p>
<sec id="s1a"><title>Risk factors for depression, anxiety, and suicidality among SGM youths</title>
<p>Recent researches suggests that loneliness, anxiety, fear of contraction, and limited access to healthcare facilities due to the Covid-19 pandemic might have worsened psychological health with heightened symptoms of depression, anxiety, self-harm, and suicidal ideation among minority groups (<xref ref-type="bibr" rid="B1">1</xref>&#x2013;<xref ref-type="bibr" rid="B4">4</xref>, <xref ref-type="bibr" rid="B15">15</xref>). For sexual minority groups, the situation was more compound because of their pre-existing psychological vulnerabilities associated with social inequalities and discrimination (<xref ref-type="bibr" rid="B5">5</xref>&#x2013;<xref ref-type="bibr" rid="B8">8</xref>). Research indicates that the Covid-19 pandemic also resulted in changes in the life circumstances of sexual minority groups. For instance, Conron (<xref ref-type="bibr" rid="B16">16</xref>) reported that several SGM young adults in the US had to return to their parental house due to the financial crisis, loss of jobs, and complete lockdown of university campuses due to the pandemic. This imposed additional pressure on them as many of them preferred avoiding their families due to non-acceptance by the family members Across the world, the socially disadvantaged SGM group faced unemployment, food insecurity, social discrimination, and severe financial crisis during the Covid-19 pandemic (<xref ref-type="bibr" rid="B17">17</xref>). All this resulted in heightened psychological vulnerabilities and declined subjective well-being among these young adults (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B8">8</xref>, <xref ref-type="bibr" rid="B18">18</xref>). Pre-existing mental health conditions such as depression, anxiety, and addiction problems, further aggravated the situation for them as they were forced to stay at home with very limited social interactions and rejection from family members (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B19">19</xref>).</p>
<p>Another line of studies pointed out that alcohol use, substance abuse, and drug dependence among SGM young adults is a common practice (<xref ref-type="bibr" rid="B20">20</xref>, <xref ref-type="bibr" rid="B21">21</xref>), even before Covid-19. As noted by Bourdieu (<xref ref-type="bibr" rid="B22">22</xref>), subtle differences in &#x201C;cultural and normative markers&#x201D; (<xref ref-type="bibr" rid="B23">23</xref>) like body language, gestures, accent, etc. can interact with demographic identities like gender, race, and ethnicity to produce hierarchical judgments potentially enough to cause discrimination in the society. Contributing factors to the higher incidence of drug dependence and substance abuse among SGM youths have often been attributed to such hierarchical power structures creating and causing inequalities in employment, health care, living conditions, and other social aspects (<xref ref-type="bibr" rid="B24">24</xref>&#x2013;<xref ref-type="bibr" rid="B27">27</xref>). Several pieces of research across the globe reported a higher incidence of substance abuse among SGM youths during Covid-19, leading to poorer mental health and self-harm tendencies. For instance, Slemon et al. (<xref ref-type="bibr" rid="B27">27</xref>) compared SGM youths with non-SGM youths in a Canadian population. The study found that in comparison to the non-SGM group, the SGM respondents had experienced a higher impact of Covid-19 and substance abuse, which included poorer psychological health, deteriorated coping, self-harm behaviors, suicidal thoughts, and greater dependence on drugs and substance abuse to survive. Similar findings were reported by Salerno et al. (<xref ref-type="bibr" rid="B8">8</xref>) in a US population. The researchers found that almost one-third of the SGM respondents had an increased level of substance abuse since the commencement of Covid-19. This increased abuse along with alcohol problems, and drug dependence contributed to ill-psychological health and complicated the situation among SGM youths.</p>
<p>Higher psychological distress among SGM youths and adolescents has been reported by several researchers. Risk factors for increased suicidality among this minority group result from symptoms of depression, hopelessness, substance abuse, psychiatric distress, and recent incidences of suicide by another family member or a friend (<xref ref-type="bibr" rid="B28">28</xref>&#x2013;<xref ref-type="bibr" rid="B30">30</xref>). During the pandemic, an elevated level of loneliness was reported in SGM adolescents and young adults (<xref ref-type="bibr" rid="B31">31</xref>, <xref ref-type="bibr" rid="B32">32</xref>). Herrmann et al. (<xref ref-type="bibr" rid="B33">33</xref>) compared the loneliness and depressive symptoms among transgender and cisgender individuals across the first and second waves of Covid-19 in a German population. The researchers noted a higher level of loneliness among transgenders in comparison to the cisgender respondents. Moreover, it was found that loneliness mediated the symptoms of depression among the SGM respondents. Jacmin-Park et al. (<xref ref-type="bibr" rid="B34">34</xref>) found that the buffering effect of perceived loss of social support due to discrimination during the pandemic on depressive symptoms was four times higher among the transgender group than the cisgender respondents. Gonzales et al. (<xref ref-type="bibr" rid="B15">15</xref>) found more frequent symptoms of psychological distress and symptoms of anxiety and depression among 60&#x0025; of American college-going SGM youths. As per the Sexual Minority Stress Model (<xref ref-type="bibr" rid="B35">35</xref>), group solidarity and social support are important protective factors for the SGM group against psychological distress associated with stigma and discrimination (<xref ref-type="bibr" rid="B34">34</xref>&#x2013;<xref ref-type="bibr" rid="B37">37</xref>).</p>
<p>Mental health issues among the SGM group associated with the Covid-19 pandemic are a crucial concern, although under-explored. Several studies have been conducted to explore the issue in the past couple of years. The present study intends to present a systematic review of the incidences of psychological distress as reported among SGM youths, especially symptoms of depression and anxiety, associated with the isolation and discrimination faced during the Covid-19 pandemic across the world. The review has the following objectives: (a) To explore the impact of Covid-19 stress on the psychological health of the sexual minority group, and (b) To identify the stressors associated with the Covid-19 pandemic that impacts the mental health well-being of the sexual minority individuals. This review will help integrate and understand the overall effect of the Covid-19 pandemic on the psychological health of the SGM youths.</p>
</sec>
</sec>
<sec id="s2"><title>Method</title>
<sec id="s2a"><title>Search method</title>
<p>The review followed the format of the PRISMA (Preferred Reporting Items for Systematic Reviews) framework. The selection process is illustrated in <xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref> which depicts the selection process following the inclusion criteria for the review. Chiefly, studies were selected from online databases namely, Google Scholar, PubMed, Eric, and PsychInfo. The keywords used for the search were &#x201C;Sexual Minority&#x201D;, &#x201C;LGBTQ&#x201D; &#x201C;Transgender&#x201D;, &#x201C;Mental Health&#x201D;, &#x201C;Covid-19&#x201D;, &#x201C;Pandemic&#x201D;, and also &#x201C;Depression&#x201D; and &#x201C;Anxiety&#x201D;, jointly and also in isolation. The review was done during the second week of September 2022. The initial search generated thousands of research out of which 140 searches were relevant in Google Scholar, 50 searches were relevant in PubMed, ERIC yielded six related searches, and PsychInfo yielded 12 searches. Relevance was judged based on the keywords used for the search. For instance, a combination of &#x201C;Mental Health&#x201D;, &#x201C;Covid-19&#x201D;, &#x201C;Pandemic&#x201D;, &#x201C;Depression&#x201D; and &#x201C;Anxiety&#x201D; keywords yielded hundreds of studies addressing populations other than sexual minority groups. Again, a search with the keyword &#x201C;Sexual Minority&#x201D;, and &#x201C;LGBTQ&#x201D; yielded research addressing different issues related to this population. Hence only those studies addressing the impact of the &#x201C;Covid-19&#x201D; &#x201C;pandemic&#x201D; on the &#x201C;Mental Health&#x201D; of the &#x201C;Sexual Minority&#x201D;/&#x201C;LGBTQ&#x201D;/&#x201C;Transgender&#x201D; population were included in the current review, yielding a total of 208 studies.</p>
<fig id="F1" position="float"><label>Figure 1</label>
<caption><p>PRISMA framework representing the selection process.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fgwh-04-1132768-g001.tif"/>
</fig>
<p><xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref> shows the PRISMA framework used for the search process. out of the relevant 208 searches yielded by the database search, 101 studies were retrieved (excluding the duplication).</p>
<p>In the next stage, the 101 studies were reviewed and 57 studies were selected focusing on the impact of Covid-19 on the mental health of the SGM group. The 44 studies rejected in this stage were focusing on intervention, policy-related issues, subjective descriptions of experiences, systematic reviews, general comparisons, and others. This review process was mostly done by analyzing the study abstracts and occasionally looking into the full paper as required. In the next stage, out of the 57 studies, 23 studies were selected after rejecting other studies focusing on methodology issues, comparisons, qualitative research, etc. Studies focusing on subjective descriptions, methodological issues, and systematic reviews were excluded since most of those addressed issues beyond the purview of the current study. Qualitative researches were also excluded because comparing results across quantitative reports using questionnaires with qualitative reports based on interviews is complicated and might invite unnecessary methodological complications.</p>
<p>Subsequently, the 23 studies (full papers) were thoroughly reviewed and finally, 16 studies were selected following the inclusion criteria: (a) Study subjects belonging to Sexual and Gender Minority groups; (b) Subjects are adults; (c) Subjects experiencing symptoms of depression and anxiety; (d) Study reported quantitative assessment (using questionnaires instead of semi-structured interviews); (e) Sample characteristics clearly mentioned; (f) Study objectives focusing on the impact of Covid-19 on the psychological health of SGM group; (g) Details of testing materials discussed clearly;(h) Statistical analysis reported and discussed elaborately; (i) Results indicate a significant impact of the pandemic on the psychological health of SGM group. These 16 studies were independently reviewed by the two authors on these inclusion criteria and then included in the review. All the studies fulfilled the inclusion criteria set for the review and are therefore considered for the present review.</p>
</sec>
<sec id="s2b"><title>Quality assessment</title>
<p>All the 16 studies were quality assessed using the Joanna Briggs Institute (JBI) checklist for analytical cross-sectional studies (<xref ref-type="bibr" rid="B38">38</xref>). The checklist consists of eight criteria assessing the quality of the studies included (related to methodological issues). The studies were rated on the checklist by both authors independently. All the studies were found to be meeting the standards of quality assessment.</p>
</sec>
</sec>
<sec id="s3" sec-type="results"><title>Results</title>
<sec id="s3a"><title>Study characteristics</title>
<p>The studies selected for the review, mostly followed online or web-based cross-sectional survey method, comparing the different sexual minority groups with cisgender heterosexual groups, except three studies that followed a Cohort design/ Longitudinal Cohort study (<xref ref-type="bibr" rid="B39">39</xref>&#x2013;<xref ref-type="bibr" rid="B41">41</xref>). For instance, Kamal et al. (<xref ref-type="bibr" rid="B41">41</xref>) considered the data collected during Wave 1 of the Covid-19 pandemic through a US-based longitudinal cohort study (CARES: Covid-19 Adult Resilience Experiences Study) for the investigation. Similarly, Chang et al. (<xref ref-type="bibr" rid="B40">40</xref>) collected data in three cohorts in 2020, January&#x2013;March (<italic>n&#x2009;</italic>&#x003D;&#x2009;99), July&#x2013;September (<italic>n&#x2009;</italic>&#x003D;&#x2009;390), and September&#x2013;November (<italic>n&#x2009;</italic>&#x003D;&#x2009;305). The second and third cohorts were finally considered for the investigation. On the other hand, the study by B&#x00E9;cares and Kneale (<xref ref-type="bibr" rid="B39">39</xref>) was a typical longitudinal cohort research that was a part of the Millennium Cohort Study done among UK infants born between 2000 and 2002. The present research included participants who had responded in the 6th and 7th data collection sweeps and during the 1st wave of the Covid-19 pandemic. Hence, this study provided a comparative view of the mental health of the SGM group during the pre-pandemic phase and the 1st wave of the pandemic. Apart from these three studies, one other study (<xref ref-type="bibr" rid="B42">42</xref>) followed a mixed method design, where a quantitative assessment was mixed with a qualitative approach and hence aided in providing a more comprehensive and rich understanding of SGM mental health issues during Covid-19 pandemic. Additionally, the study by Gato et al. (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>) did a cross-country exploration among LGBTQ&#x002B; individuals from six different nations. This study, therefore, provides a more in-depth insight into the prevalence of psychological distress among the SGM group across different nations. It is important to note that all the studies followed a web-based survey method, considering the physical restrictions imposed during the pandemic. <xref ref-type="table" rid="T1">Table&#x00A0;1</xref> provides a comparative view of the study characteristics and demographics of the study participants of all sixteen studies included in the review.</p>
<table-wrap id="T1" position="float"><label>Table 1</label>
<caption><p>Comparative view of the study characteristics and demographics of the study participants.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="left"/>
<col align="left"/>
<col align="left"/>
<col align="left"/>
<col align="left"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Author(s) with year</th>
<th valign="top" align="center">Study design</th>
<th valign="top" align="center">Sample size</th>
<th valign="top" align="center">Age</th>
<th valign="top" align="center">Sexual orientation</th>
<th valign="top" align="center">Racial/ethnic group</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Oren (<xref ref-type="bibr" rid="B43">43</xref>)</td>
<td valign="top" align="left">Correlational Study</td>
<td valign="top" align="left">157 Adults</td>
<td valign="top" align="left">Mean age&#x2009;&#x003D;&#x2009;26 years</td>
<td valign="top" align="left">Lesbian, Gay, Bisexual</td>
<td valign="top" align="left">Israeli population</td>
</tr>
<tr>
<td valign="top" align="left">Akre et al. (<xref ref-type="bibr" rid="B44">44</xref>)</td>
<td valign="top" align="left">comparative study using quota sampling method</td>
<td valign="top" align="left">3,245 adults</td>
<td valign="top" align="left">18 years or older</td>
<td valign="top" align="left">Transgender and cisgender</td>
<td valign="top" align="left">US population</td>
</tr>
<tr>
<td valign="top" align="left">Kneale and B&#x00E9;cares (<xref ref-type="bibr" rid="B45">45</xref>)</td>
<td valign="top" align="left">Cross-sectional Web based survey</td>
<td valign="top" align="left">310 adults</td>
<td valign="top" align="left">18 years or older</td>
<td valign="top" align="left">Lesbian, Gay, Bisexual, Queer, having another minority sexual minority, transgender people.</td>
<td valign="top" align="left">UK population</td>
</tr>
<tr>
<td valign="top" align="left">Moore et al. (<xref ref-type="bibr" rid="B46">46</xref>)</td>
<td valign="top" align="left">Online Cross-sectional Study</td>
<td valign="top" align="left">1,380 respondents (290 SGM adults and 1,090 cisgender heterosexual adults)</td>
<td valign="top" align="left">Mean age of SGM respondent&#x2009;&#x003D;&#x2009;34.26 years; Mean age of cisgender group&#x2009;&#x003D;&#x2009;46.12 years</td>
<td valign="top" align="left">15.2&#x0025; Lesbian, 18.3&#x0025; Gay, 50.7&#x0025; Bisexual, 22.1&#x0025; Queer, 5.5&#x0025; Heterosexual, 12.4&#x0025; Asexual,.7&#x0025; Calibate, 6.2&#x0025; decline to answer</td>
<td valign="top" align="left">US population (&#x003E;90&#x0025; white population, rest included Black, Asian, Alaskan native, Hispanic, Hawaiian native and others)</td>
</tr>
<tr>
<td valign="top" align="left">Suen et al. (<xref ref-type="bibr" rid="B47">47</xref>)</td>
<td valign="top" align="left">Community based online survey</td>
<td valign="top" align="left">857 adults</td>
<td valign="top" align="left">55&#x0025; aged between 16 and 25 years, 33.6&#x0025; between 26 and 35 years, 11.4&#x0025; aged above 36 years.</td>
<td valign="top" align="left">61.1&#x0025; Lesbian/Gay, 32.2&#x0025; Bisexual or Pansexual, and 6.7&#x0025; others (queer, asexual, etc.)</td>
<td valign="top" align="left">Hong Kong population</td>
</tr>
<tr>
<td valign="top" align="left">Gato et al. (<xref ref-type="bibr" rid="B7">7</xref>)</td>
<td valign="top" align="left">Online survey</td>
<td valign="top" align="left">403 respondents</td>
<td valign="top" align="left">Age range&#x2009;&#x003D;&#x2009;16&#x2013;30<break/>Mean age: 22.13 years</td>
<td valign="top" align="left">56.6&#x0025; Lesbian/Gay, 27.9&#x0025; Bisexual, 11.7&#x0025; Pansexual, 1.2&#x0025; Asexual, 1.7&#x0025; Heterosexual, 1&#x0025; Other (Queer)</td>
<td valign="top" align="left">Portuguese population</td>
</tr>
<tr>
<td valign="top" align="left">B&#x00E9;cares and Kneale (<xref ref-type="bibr" rid="B39">39</xref>)</td>
<td valign="top" align="left">Cohort Study with longitudinal data</td>
<td valign="top" align="left">2,211 respondents</td>
<td valign="top" align="left">Mostly aged 19 years during data collection</td>
<td valign="top" align="left">Heterosexual and Sexual Minority respondents (detailed category not considered due to small cohorts)</td>
<td valign="top" align="left">UK population (86&#x0025; white, 4.5&#x0025; mixed and 9.5&#x0025; Indian, black, Pakistani or Bangladeshi and others)</td>
</tr>
<tr>
<td valign="top" align="left">Urz&#x00FA;a et al. (<xref ref-type="bibr" rid="B48">48</xref>)</td>
<td valign="top" align="left">Cross-sectional study under an observational design</td>
<td valign="top" align="left">1,181 respondents</td>
<td valign="top" align="left">18&#x2013;64 years; Mean Age<sub>Homosexual&#x2009;</sub>&#x003D;&#x2009;31.5 years; Mean Age<sub>Bisexual&#x2009;</sub>&#x003D;&#x2009;24.5 years; Mean Age<sub>Other Sexual orientation</sub>&#x2009;&#x003D;&#x2009;25 years</td>
<td valign="top" align="left">64&#x0025; identified as homosexual, 23&#x0025; identified as bisexual, 13&#x0025; identified as having other sexual orientation (pansexual, demisexual, asexual, etc.)</td>
<td valign="top" align="left">Chilean population</td>
</tr>
<tr>
<td valign="top" align="left">Chang et al. (<xref ref-type="bibr" rid="B31">31</xref>)</td>
<td valign="top" align="left">Cohort Study</td>
<td valign="top" align="left">695 sexual minority adults</td>
<td valign="top" align="left">Age range&#x2009;&#x003D;&#x2009;18&#x2013;29 years; Mean age&#x2009;&#x003D;&#x2009;23.09 years</td>
<td valign="top" align="left">50.2&#x0025; Lesbian/Gay; 49.8&#x0025; Bisexual, Pansexual and others</td>
<td valign="top" align="left">US population; 60.6&#x0025; white, 12.5&#x0025; Latin, 10.5&#x0025; Asian, 8.3&#x0025; Black, 7.3&#x0025; Biracial or multiracial, 1.2&#x0025; others.</td>
</tr>
<tr>
<td valign="top" align="left">Kamal et al. (<xref ref-type="bibr" rid="B32">32</xref>)</td>
<td valign="top" align="left">Longitudinal Cohort Study</td>
<td valign="top" align="left">981 adults</td>
<td valign="top" align="left">Mean age&#x2009;&#x003D;&#x2009;24.37 years</td>
<td valign="top" align="left">63.6&#x0025; Heterosexual and 32.6&#x0025; Sexual Minority group</td>
<td valign="top" align="left">US population; 60.8&#x0025; white, 20.9&#x0025; Asian, 6.3&#x0025; Mixed, 5.8&#x0025; Hispanic, 4.8&#x0025; Black, 1.5&#x0025; others.</td>
</tr>
<tr>
<td valign="top" align="left">Salerno et al. (<xref ref-type="bibr" rid="B8">8</xref>)</td>
<td valign="top" align="left">Cross-sectional study</td>
<td valign="top" align="left">294 sexual minority young adults and 894 non-sexual minority young adults</td>
<td valign="top" align="left">Age Range&#x2009;&#x003D;&#x2009;18&#x2013;26<break/>Mean age&#x2009;&#x003D;&#x2009;22 years</td>
<td valign="top" align="left">Heterosexual, Bisexual (Lesbian/Gay), Other</td>
<td valign="top" align="left">Sexual minority group:<break/>55.4&#x0025; white,.07&#x0025; Latino,.06&#x0025; black, 11.56&#x0025; Asian, 17.7&#x0025; Multiracial,.03&#x0025; Other</td>
</tr>
<tr>
<td valign="top" align="left">Hart et al. (<xref ref-type="bibr" rid="B49">49</xref>)</td>
<td valign="top" align="left">Online Survey</td>
<td valign="top" align="left">830 LGBTQ&#x2009;&#x002B;&#x2009;adults</td>
<td valign="top" align="left">Age range&#x2009;&#x003D;&#x2009;18&#x2013;30 years; Mean age&#x2009;&#x003D;&#x2009;20.6 years</td>
<td valign="top" align="left">36.4&#x0025; Bisexual, 24.5&#x0025; Gay, 14.8&#x0025; multiple orientation, 7.2&#x0025; Queer, 6.3&#x0025; Asexual, 0.7&#x0025; Heterosexual, 1.3&#x0025; Other, 8.3&#x0025; Unsure</td>
<td valign="top" align="left">US population (69.9&#x0025; White, 10.1&#x0025; Multiracial, 8.3&#x0025; Asian, 7.5&#x0025; Latin, 2.2&#x0025; Black, 1.2&#x0025; Other, 0.7&#x0025; preferred not to say)</td>
</tr>
<tr>
<td valign="top" align="left">Goodyear et al. (<xref ref-type="bibr" rid="B50">50</xref>)</td>
<td valign="top" align="left">Cross-sectional survey</td>
<td valign="top" align="left">502 LGBTQ2&#x2009;&#x002B;&#x2009;adults</td>
<td valign="top" align="left">Age Range&#x2009;&#x003D;&#x2009;18 years and above; 28.3&#x0025; aged 18&#x2013;34 years, 41.8&#x0025; aged 35&#x2013;54 years, 29.9&#x0025; aged above 55 years</td>
<td valign="top" align="left">Lesbian, Gay, Bisexual, Transgender, Queer, Two-Spirit etc.</td>
<td valign="top" align="left">Canadian population; 69.2&#x0025; of European origin, 25.5&#x0025; having non-European origin, 5.4&#x0025; of indigenous origin</td>
</tr>
<tr>
<td valign="top" align="left">Tabler et al. (<xref ref-type="bibr" rid="B33">33</xref>)</td>
<td valign="top" align="left">Convergent mixed method design</td>
<td valign="top" align="left">411 LGBTQ&#x2009;&#x002B;&#x2009;adults</td>
<td valign="top" align="left">Age range&#x2009;&#x003D;&#x2009;18&#x2013;86 years; Mean age&#x2009;&#x003D;&#x2009;28.5 years.</td>
<td valign="top" align="left">71&#x0025; Heterosexual (56&#x0025; women), 29&#x0025; LGBTQ&#x2009;&#x002B;&#x2009;individuals</td>
<td valign="top" align="left">US population (87&#x0025; White, 13&#x0025; Latinx).</td>
</tr>
<tr>
<td valign="top" align="left">Gato et al. (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>)</td>
<td valign="top" align="left">Cross country exploratory research</td>
<td valign="top" align="left">1,934 LGBTQ&#x2009;&#x002B;&#x2009;young adults</td>
<td valign="top" align="left">Age range&#x2009;&#x003D;&#x2009;18&#x2013;29 years; Mean age&#x2009;&#x003D;&#x2009;22.70 years</td>
<td valign="top" align="left">52&#x0025; Lesbian/Gay, 32.3&#x0025; Bisexual, 5.0&#x0025; Pansexual, 1.8&#x0025; Asexual, 1.3&#x0025; Heterosexual, 7.5&#x0025; Other (Queer etc.)</td>
<td valign="top" align="left">Participants from six countries;<break/>Portugal: 18.6&#x0025;,<break/>UK: 5&#x0025;<break/>Italy: 5.5&#x0025;<break/>Brazil: 32.2&#x0025;<break/>Chile: 37.0&#x0025;<break/>Sweden: 1.8&#x0025;</td>
</tr>
<tr>
<td valign="top" align="left">Fish et al. (<xref ref-type="bibr" rid="B5">5</xref>)</td>
<td valign="top" align="left">Cross-sectional Online survey</td>
<td valign="top" align="left">2,996 adults (18.06&#x0025; sexual minority)</td>
<td valign="top" align="left">Mean age&#x2009;&#x003D;&#x2009;32.20 years</td>
<td valign="top" align="left">81.94&#x0025; Heterosexual, 0.04&#x0025; Lesbian/Gay, 11.58&#x0025; Bisexual, 0.03&#x0025; Other.</td>
<td valign="top" align="left">US population; 64.49&#x0025; White, 6.48&#x0025; Latina/o/x, 7.08&#x0025; Black, 11.95&#x0025; Asian American, 9.71&#x0025; Multiracial, Multiethnic or other</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="s3b"><title>Sample characteristics</title>
<p>Out of the 16 studies, seven studies presented a comparative account across heterosexual and SGM respondents (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B8">8</xref>, <xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B32">32</xref>, <xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B44">44</xref>, <xref ref-type="bibr" rid="B46">46</xref>), while three more studies included heterosexual respondents although in very small percentages (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B49">49</xref>). The rest of the studies included only the SGM group for the investigation. Participants of all the studies were adults with mostly young age groups included in the research. Additionally, the studies considered for the review include participants from across a wide range of race/ethnic groups. Eight studies were conducted on the US population (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B8">8</xref>, <xref ref-type="bibr" rid="B31">31</xref>&#x2013;<xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B44">44</xref>, <xref ref-type="bibr" rid="B46">46</xref>, <xref ref-type="bibr" rid="B49">49</xref>), although the US population included in the studies was a heterogenous mix of Asian American, Latin American, African American, and multiracial origins along with White Americans. Two studies were conducted among the UK population (<xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B45">45</xref>), also a heterogeneous group of white individuals, mixed racial groups, and Asian individuals. The rest of the studies included participants representing several different countries like Israel (<xref ref-type="bibr" rid="B43">43</xref>), Hong Kong (<xref ref-type="bibr" rid="B47">47</xref>), Portugal (<xref ref-type="bibr" rid="B7">7</xref>), Chile (<xref ref-type="bibr" rid="B48">48</xref>), and Canada (<xref ref-type="bibr" rid="B50">50</xref>). Gato et al. (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>) included participants from six different countries namely, Portugal, the UK, Italy, Brazil, Chile, and Sweden. Hence, the study results are representative of the mental health scenario of the SGM group across a wide geographical region.</p>
</sec>
<sec id="s3c"><title>Study measures</title>
<p>All the studies included in the review assessed the psychological distress related to Covid-19 and the associated symptoms of depression and anxiety among SGM individuals. While the measures for assessing depression and anxiety were all standardized instruments (for instance, 8-item Patient Health Questionnaire (PHQ-8), Kroenke, et al. (<xref ref-type="bibr" rid="B51">51</xref>) and 7-item Generalized Anxiety Disorder scale (GAD-7) (<xref ref-type="bibr" rid="B52">52</xref>); Depression Anxiety Stress Scales (DASS-21), Lovibond and Lovibond (<xref ref-type="bibr" rid="B53">53</xref>), most studies used customized questions to assess the Covid-19 related stress (for instance (<xref ref-type="bibr" rid="B31">31</xref>, <xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B46">46</xref>, <xref ref-type="bibr" rid="B47">47</xref>, <xref ref-type="bibr" rid="B50">50</xref>). The chief reason cited for this practice was a lack of a standardized scale for measuring stress related to Covid-19 among SGM individuals, although Tabler et al. (<xref ref-type="bibr" rid="B33">33</xref>) used the Pandemic Stress Scale developed by Taylor et al. (<xref ref-type="bibr" rid="B54">54</xref>).</p>
<p>Apart from anxiety, depression, and psychological distress, several studies also measured perceived social support (<xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B32">32</xref>&#x2013;<xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B46">46</xref>). The most commonly used measure was the modified Medical Outcomes Study Social Support Survey (8-items) (<xref ref-type="bibr" rid="B55">55</xref>), although Kamal et al. (<xref ref-type="bibr" rid="B32">32</xref>) and Oren (<xref ref-type="bibr" rid="B43">43</xref>) used the 12-item Multidimensional Scale of Perceived Social Support (<xref ref-type="bibr" rid="B57">57</xref>) for measuring the same. Some of the studies also studied variables like Loneliness, Rumination, and Quality of relationships in addition to the stress and psychological symptoms related to Covid-19. Additionally, Hart et al. (<xref ref-type="bibr" rid="B49">49</xref>) and Tabler et al. (<xref ref-type="bibr" rid="B33">33</xref>) measured eating disorder symptoms as well using the Eating Disorder Examination-Questionnaire (<xref ref-type="bibr" rid="B58">58</xref>) and Eating Disorder Examination&#x2014;Questionnaire Short (EDE-QS) (12 items) (<xref ref-type="bibr" rid="B59">59</xref>, <xref ref-type="bibr" rid="B60">60</xref>) respectively. Akre et al. (<xref ref-type="bibr" rid="B44">44</xref>) and Goodyear et al. (<xref ref-type="bibr" rid="B50">50</xref>) measured problem drinking using the Patient-Reported Outcomes Measurement Information System (PROMIS) and substance use through a set of semi-structured questions. <xref ref-type="table" rid="T2">Table&#x00A0;2</xref> presents a detailed account of the measures used in the studies.</p>
<table-wrap id="T2" position="float"><label>Table 2</label>
<caption><p>Comparative view of the study measure and study outcomes.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="left"/>
<col align="left"/>
<col align="left"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Author(s) with Year</th>
<th valign="top" align="center">Study Variables</th>
<th valign="top" align="center">Study Measures</th>
<th valign="top" align="center">Study Outcomes</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Oren (<xref ref-type="bibr" rid="B43">43</xref>)</td>
<td valign="top" align="left">COVID-19 stress, internalized homophobia, concealment, need of acceptance, social support, anxiety, and depression.</td>
<td valign="top" align="left">Stress related to COVID-19 was assessed by asking four questions developed by the author; Internalized homophobia was measured by the 9-item Internalized Homophobia Scale; Concealment motivation and Acceptance Need were measured by the three-item Concealment Motivation subscale and the five item Acceptance Need subscale of the Lesbian, Gay and Bisexual Identity Scale (<xref ref-type="bibr" rid="B61">61</xref>), 12-item Multidimensional Scale of Perceived Social Support (MSPSS; Zimet et al. 1988) for measuring Social Support; Four-item Symptom Checklist Anxiety and six-item Symptom Checklist Depression scales (<xref ref-type="bibr" rid="B62">62</xref>) were used for measuring Anxiety and Depression.</td>
<td valign="top" align="left">The findings stressed upon the significance of minority stress, focused on the psychological mediation framework, and emphasized the need to study the differential impact of stress on the psychological health of SGM individuals.</td>
</tr>
<tr>
<td valign="top" align="left">Akre et al. (<xref ref-type="bibr" rid="B44">44</xref>)</td>
<td valign="top" align="left">Depression, anxiety, and problem drinking</td>
<td valign="top" align="left">Patient-Reported Outcomes Measurement Information System (PROMIS) measures to assess depression, anxiety, and problem drinking during the COVID-19 pandemic (<xref ref-type="bibr" rid="B63">63</xref>).</td>
<td valign="top" align="left">LGBTQ1 communities reported poorer psychological health and more frequent problem drinking than the cisgender heterosexual respondents during the COVID-19 pandemic.</td>
</tr>
<tr>
<td valign="top" align="left">Kneale and B&#x00E9;cares (<xref ref-type="bibr" rid="B45">45</xref>)</td>
<td valign="top" align="left">Perceived stress, Depression</td>
<td valign="top" align="left">4-item Perceived Stress Scale (<xref ref-type="bibr" rid="B64">64</xref>); 10- item Center for Epidemiological Studies Depression scale (CES-D-10) (<xref ref-type="bibr" rid="B65">65</xref>).</td>
<td valign="top" align="left">Findings revealed that poorer mental health among SGM individuals could be partially accounted for by experiences of social discrimination, the latter having a debilitating impact on the subjective well being of the SGM individuals.</td>
</tr>
<tr>
<td valign="top" align="left">Moore et al. (<xref ref-type="bibr" rid="B46">46</xref>)</td>
<td valign="top" align="left">Physical symptoms, psychological symptoms, rumination, and perceived social support.</td>
<td valign="top" align="left">COVID-19-related self-report items, Sexual and gender identity Questions; 21-item measure asking about a variety of COVID-19 and non-COVID-19 related physical symptoms; 8-item Patient Health Questionnaire (PHQ-8) (<xref ref-type="bibr" rid="B51">51</xref>); 7-item Generalized Anxiety Disorder scale (GAD-7) measure of anxiety symptom (<xref ref-type="bibr" rid="B52">52</xref>); 19-item Medical Outcomes Study Social Support Survey (MOS4) (<xref ref-type="bibr" rid="B66">66</xref>); 10-item Ruminative Response Scale (<xref ref-type="bibr" rid="B66">66</xref>).</td>
<td valign="top" align="left">It was noted that SGM respondents had more often experienced COVID-19-related bodily symptoms and psychological symptoms of depression and anxiety.</td>
</tr>
<tr>
<td valign="top" align="left">Suen et al. (<xref ref-type="bibr" rid="B47">47</xref>)</td>
<td valign="top" align="left">COVID 19 stressors, Depression, Anxiety</td>
<td valign="top" align="left">Questions on COVID-19-related stressors, 9-item Patient Health Questionnaire (PHQ-9) for depression (Kroenke et al. 2001), 7-item Generalized Anxiety Disorder for anxiety (<xref ref-type="bibr" rid="B52">52</xref>).</td>
<td valign="top" align="left">Findings revealed that the Covid-19 related stressors experienced by the SGM individuals, in addition to the general stressors associated with the pandemic, mediated the symptoms of depression and anxiety among them.</td>
</tr>
<tr>
<td valign="top" align="left">Gato et al. (2020)</td>
<td valign="top" align="left">Depression, anxiety, and Stress</td>
<td valign="top" align="left">Portuguese version of the Depression, Anxiety and Stress Scales 21-Item Version (DASS-21) (<xref ref-type="bibr" rid="B67">67</xref>, <xref ref-type="bibr" rid="B68">68</xref>).</td>
<td valign="top" align="left">Findings revealed that the association between the pandemic&#x0027;s individual impact and both depression and anxiety are partially mediated by family climate.</td>
</tr>
<tr>
<td valign="top" align="left">B&#x00E9;cares and Kneale (<xref ref-type="bibr" rid="B39">39</xref>)</td>
<td valign="top" align="left">Social support, Self-rated health, psychological distress, anxiety, loneliness</td>
<td valign="top" align="left">Questions related to Sexual Orientation, Kessler 6 scale for psychological distress (Kessler, 2006); Generalized Anxiety Disorder (2 items) questionnaire (Kroenke et al. 2007); UCLA Loneliness Scale, Short Social Provisions scale (3 items) (<xref ref-type="bibr" rid="B69">69</xref>).</td>
<td valign="top" align="left">Findings reported significantly poor social support among SGM young adults, worse self-rated health, and more severe psychological distress, anxiety, and loneliness in comparison to heterosexual counterparts.</td>
</tr>
<tr>
<td valign="top" align="left">Urz&#x00FA;a et al. (<xref ref-type="bibr" rid="B48">48</xref>)</td>
<td valign="top" align="left">Anxiety, Depression, Stress</td>
<td valign="top" align="left">Spanish version of Depression Anxiety Stress Scales (DASS-21) was used to measure Anxiety, Depression and Stress (<xref ref-type="bibr" rid="B70">70</xref>); Lovibond and Lovibond, 1995a; 1995b; (<xref ref-type="bibr" rid="B71">71</xref>).</td>
<td valign="top" align="left">Poorer mental health was observed among the bisexual and other sexual orientations (pansexual, demisexual, asexual) group as opposed to gays and lesbians. Findings suggest a higher occurrence of depressive symptoms and anxiety, related to stress. Moreover, bisexual women presented a higher prevalence of symptoms related to psychological distress than men. A similar trend in anxiety symptoms was observed among lesbians, as compared to gay individuals.</td>
</tr>
<tr>
<td valign="top" align="left">Chang et al. (<xref ref-type="bibr" rid="B31">31</xref>)</td>
<td valign="top" align="left">Depression, Negative Impact of COVID-19</td>
<td valign="top" align="left">8-item version of the Patient Health Questionnaire (PHQ-8) (<xref ref-type="bibr" rid="B51">51</xref>), Negative Impact of COVID-19 assessed by one question with ratings from 1 to 10.</td>
<td valign="top" align="left">Results indicated that transgender or gender-diverse women who are full-time students are at a higher risk of getting affected by the pandemic. Moreover, the study confirmed the association between the negative effect of Covid-19 and depressive symptoms at a two-month follow-up.</td>
</tr>
<tr>
<td valign="top" align="left">Kamal et al. (<xref ref-type="bibr" rid="B32">32</xref>)</td>
<td valign="top" align="left">Perceived social support; Lifetime discrimination; severity of COVID-19-related worries and COVID-19- related grief; Depression; Anxiety, PTSD symptoms.</td>
<td valign="top" align="left">12-item Multidimensional Scale of Perceived Social Support (MSPSS) for measuring Perceived social support (<xref ref-type="bibr" rid="B55">55</xref>).; Lifetime discrimination was assessed using the 11-item Lifetime Discrimination Scale (Williams et al. 1997); Two 6-item scales, that have been used in previously published work, assessed the severity of COVID-19-related worries and COVID-19- related grief (Liu et al. 2020a; 2020b); 8-item version of the Patient Health Questionnaire (PHQ-8) for Depression (Kroenke et al. 2001); 7-item version of the Generalized Anxiety Disorder Scale (GAD-7) for Anxiety (<xref ref-type="bibr" rid="B52">52</xref>); 17-item version of the PTSD Checklist&#x2014;Civilian Version (PCL-C) for PTSD symptoms.</td>
<td valign="top" align="left">Study findings reported significantly more severe symptoms of depression and PTSD as also COVID-19-related worries and grief among the SGM respondents in comparison to the non-SGM counterparts. The effect persisted even after controlling for the effects of family support, lifetime discrimination, and pre-existing mental health diagnoses.</td>
</tr>
<tr>
<td valign="top" align="left">Salerno et al. (<xref ref-type="bibr" rid="B8">8</xref>)</td>
<td valign="top" align="left">Psychological distress, well-being, pre-and post-onset of COVID-19 living circumstances.</td>
<td valign="top" align="left">6-item Kessler-6 (K6) (<xref ref-type="bibr" rid="B72">72</xref>) psychological distress scale measured nervousness, hopelessness, restlessness, depression, worthlessness, and whether everything is an effort within the past 30 days; Cantril Ladder measured self-rated well-being (<xref ref-type="bibr" rid="B73">73</xref>); pre-and post-onset of COVID-19 living circumstances were measured with specific questions.</td>
<td valign="top" align="left">Findings revealed that SMYAs who went back to their parents&#x2019; residence after the onset of COVID-19, reported higher levels of psychological distress and lower levels of psychological well-being, in comparison to those who were already staying with their parents both pre- and post-onset of COVID-19 pandemic.</td>
</tr>
<tr>
<td valign="top" align="left">Hart et al. (<xref ref-type="bibr" rid="B49">49</xref>)</td>
<td valign="top" align="left">Eating behavior, Quality of relationship, Psychological stress symptoms</td>
<td valign="top" align="left">A brief and modified version of the COVID-19 Adult Experiences and Psychological Symptoms Questionnaire (<xref ref-type="bibr" rid="B74">74</xref>); Quality of Relationships Inventory (QRI)-support scale (<xref ref-type="bibr" rid="B75">75</xref>); Dietary Restriction Screener 2 (DRS-2) (<xref ref-type="bibr" rid="B76">76</xref>); Eating Disorder Examination-Questionnaire (<xref ref-type="bibr" rid="B57">57</xref>).</td>
<td valign="top" align="left">The study reported minor but significant association among variations in average disordered eating behaviour severity and interpersonal relationships, average quality of relationships in the home, and staying with someone not accepting one&#x0027;s identity.</td>
</tr>
<tr>
<td valign="top" align="left">Goodyear et al. (<xref ref-type="bibr" rid="B50">50</xref>)</td>
<td valign="top" align="left">Substance abuse, Coping, Self-reported change in mental health, Suicidal thoughts</td>
<td valign="top" align="left">Substance use was assessed by asking participants to &#x201C;indicate how your use of any of the following has been impacted by the COVID-19 pandemic&#x201D;, including &#x201C;Drinking alcohol&#x201D; and &#x201C;Use of cannabis products&#x201D;. Response options included &#x201C;More&#x201D;, &#x201C;Less&#x201D;, &#x201C;No change&#x201D;, &#x201C;Not applicable&#x201D;, and &#x201C;Prefer not to say&#x201D;. Respondents who indicated &#x201C;More&#x201D; were classified as having increased their use of the respective substance, whereas those who indicated &#x201C;Less&#x201D;, &#x201C;No change&#x201D;, and &#x201C;Not applicable&#x201D; were classified as not having increased their substance use. Coping was assessed through the question, &#x201C;Overall, how well do you think you are coping with stress related to the COVID-19 pandemic?&#x201D; Response options &#x201C;Not very well&#x201D; and &#x201C;Not well at all&#x201D; were classified as poor coping, whereas responses &#x201C;Very well&#x201D; and &#x201C;Fairly well&#x201D; were classified as not poor coping. Self-reported change in mental health was also assessed by asking participants, &#x201C;Compared to before the COVID-19 pandemic and related restrictions in Canada, how would you say your mental health is now?&#x201D; Response options &#x201C;Slightly worse now&#x201D; and &#x201C;Significantly worse now&#x201D; were classified as experiencing worse mental health, whereas responses &#x201C;Significantly better now&#x201D;, &#x201C;Slightly better now&#x201D;, and &#x201C;About the same&#x201D; were classified as not experiencing a deterioration in mental health. Suicidal thoughts were then assessed through a question asking whether participants had &#x201C;Experienced suicidal thoughts/feelings&#x201D; within the past two weeks.</td>
<td valign="top" align="left">Researchers noted that increased alcohol use among 24.5&#x0025; of the respondents and 18.5&#x0025; reported increased cannabis use due to the pandemic. Furthermore, they found that higher levels of alcohol use were associated with worse coping skills and poor self-reported psychological health. On the other hand, increased use of cannabis was found to be related to suicidal thoughts.</td>
</tr>
<tr>
<td valign="top" align="left">Tabler et al. (<xref ref-type="bibr" rid="B33">33</xref>)</td>
<td valign="top" align="left">Eating disorder, Pandemic stress, LGBTQ Identity, Resilience, Social Support</td>
<td valign="top" align="left">Eating Disorder Examination&#x2014;Questionnaire Short (EDE-QS)(12 items) (<xref ref-type="bibr" rid="B48">48</xref>, <xref ref-type="bibr" rid="B49">49</xref>); Pandemic stress scale (5 items) (<xref ref-type="bibr" rid="B44">44</xref>), LGBTQ&#x2009;&#x002B;&#x2009;identity combines information from self-reported sex assigned at birth, gender identity, and sexual identity, to create a 3-category measure comparing cisgender and heterosexual (cishet) women, and LGBTQ&#x2009;&#x002B;&#x2009;identifying participants, to cishet men, Brief Resilient Coping Scale (4-items) (<xref ref-type="bibr" rid="B77">77</xref>), modified Medical Outcomes Study Social Support Survey (8-items) (<xref ref-type="bibr" rid="B45">45</xref>).</td>
<td valign="top" align="left">Study results suggest that LGBTQ&#x2009;&#x002B;&#x2009;individuals are more vulnerable to experiencing a uniquely increased level of pandemic-related stress. Also, the stress related to the pandemic is associated with increased symptoms of eating disorders and elevated risk of perceived weight gain, with almost 1 in 3 participants reporting clinically significant symptoms of eating disorders. Moreover, social support, as opposed to resilient coping, was found to be a potential protective shield against elevated symptoms of the eating disorder.</td>
</tr>
<tr>
<td valign="top" align="left">Gato et al. (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>)</td>
<td valign="top" align="left">Psychosocial effects of the COVID-19 pandemic, Depression, Anxiety and Stress</td>
<td valign="top" align="left">Psychosocial effects of the COVID-19 pandemic (7 items) (Gato et al., 2020), Depression, Anxiety and Stress Scales 21-Item Version (DASS-21) (<xref ref-type="bibr" rid="B66">66</xref>); and sociodemographic questionnaire were used.</td>
<td valign="top" align="left">Younger, non-working participants, living in Europe, and those reporting feeling uncomfortable, isolated, and more emotionally distraught by the pandemic, experienced higher levels of depression and anxiety. Furthermore, depression was predicted by not having higher education, while anxiety was predicted by being isolated at home, having to stay with parents, and worries about contraction.</td>
</tr>
<tr>
<td valign="top" align="left">Fish et al. (<xref ref-type="bibr" rid="B5">5</xref>)</td>
<td valign="top" align="left">Mental health, physical health, quality of life, Psychological distress, Loneliness, Alcohol use, Sexual Identity.</td>
<td valign="top" align="left">Self-reported mental health, physical health, and quality of life were each assessed using a single item adapted from the Centers for Disease Control and Prevention&#x0027;s &#x201C;Healthy Days Measure&#x201D; (<xref ref-type="bibr" rid="B78">78</xref>); Psychological distress was assessed using the Kessler 6 (<xref ref-type="bibr" rid="B79">79</xref>); Loneliness was assessed using four items from the UCLA Loneliness Scale (<xref ref-type="bibr" rid="B80">80</xref>); Alcohol use was assessed with two items; Sexual identity was assessed by asking objective questions.</td>
<td valign="top" align="left">Findings revealed consistent patterns of deterioration in psychological well-being across the SGM subgroups, nonetheless, variations in mental health, physical health, quality of life, stress, and psychological distress were more profound among the SGM adults in comparison to the heterosexual adults.</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="s3d"><title>Study outcomes</title>
<p>Almost all the studies highlighted the significance of the&#x00A0;impact of Covid-19 related stress on the psychological health of minority individuals. It can be noted that the studies&#x00A0;identified potential Covid-19 stressors that contribute to an increased level of psychological distress among SGM individuals.</p>
</sec>
<sec id="s3e"><title>Depression and anxiety symptoms related to COVID-19 stress</title>
<p>Increased levels of anxiety and depression were found to be associated with the perceived stress related to the Covid-19 pandemic. Most of the researchers reported such elevated symptoms during the first wave of the pandemic and also during the subsequent waves. Severe symptoms of depression and anxiety were also found to be associated with Covid-19 related physical symptoms (<xref ref-type="bibr" rid="B46">46</xref>), psychological distress (c), loneliness (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B39">39</xref>), and poor quality of life (<xref ref-type="bibr" rid="B5">5</xref>). Kamal et al. (<xref ref-type="bibr" rid="B32">32</xref>) additionally, reported symptoms of post-traumatic stress disorder associated with higher levels of depression among SGM youths.</p>
<p>Most commonly such experience of psychological distress was attributed to stressors like perceived social support (<xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B32">32</xref>&#x2013;<xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B46">46</xref>), family-related issues (<xref ref-type="bibr" rid="B8">8</xref>), social discriminations (<xref ref-type="bibr" rid="B32">32</xref>) and non-affirmation of one&#x0027;s identity (<xref ref-type="bibr" rid="B43">43</xref>).</p>
</sec>
<sec id="s3f"><title>Perceived social support and COVID-19 stress</title>
<p>In connection to the issue of social support, Meyer (<xref ref-type="bibr" rid="B35">35</xref>) proposed the Minority Stress Model in association with lesbian, gay, and bisexual (LGB) health. As per the minority stress model, stressors can be distal or proximal. Distal stressors are characterized by the actual experiences of discrimination, prejudices, harassment, and even violence, while the proximal stressors include the occurrence of internalized homophobia, the need for acceptance by others, and the suppression of one&#x0027;s own sexual identity (<xref ref-type="bibr" rid="B43">43</xref>). Several researchers have provided evidence for the fact that such minority distal and proximal stressors lead to elevated levels of psychological distress, a relationship mediated by the development of pathological cognitive processes, and conflictual social and interpersonal relationships (<xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B81">81</xref>). In contrast, perceived social support works as a buffer against the negative effects of minority stressors and therefore can be considered an important resource in protecting SGM mental health (<xref ref-type="bibr" rid="B35">35</xref>, <xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B82">82</xref>).</p>
<p>Tabler et al. (<xref ref-type="bibr" rid="B33">33</xref>) noted that social support plays an important role as a potential protective safeguard against the elevated risks of disordered eating symptoms associated with Covid-19 stress. These findings were further validated by the work of B&#x00E9;cares and Kneale (<xref ref-type="bibr" rid="B39">39</xref>) who noted a significantly poorer level of perceived social support associated with lower levels of self-rated health and poor psychological health among the SGM respondents. Moore et al. (<xref ref-type="bibr" rid="B46">46</xref>), in a comparison study among SGM and non-SGM adults, noted significantly lower perception (<italic>p&#x2009;&#x003C;&#x2009;.001</italic>) of emotional support, tangible support, affectionate support, and positive social interaction support among the SGM respondents in comparison to their non-SGM counterparts. The study also reported significantly heightened symptoms of depression and anxiety among the SGM adults in comparison to the non-SGM respondents. Such findings, therefore, suggest that lack of perceived social support acted as a potential stressor for the SGM individuals under the impact of the Covid-19 pandemic.</p>
</sec>
<sec id="s3g"><title>Family support and psychological distress related to COVID-19</title>
<p>There is no dearth of studies reporting a lack of family support among sexual minority groups (<xref ref-type="bibr" rid="B32">32</xref>, <xref ref-type="bibr" rid="B83">83</xref>, <xref ref-type="bibr" rid="B84">84</xref>). Kamal et al. (<xref ref-type="bibr" rid="B32">32</xref>) found that SGM respondents experienced a significantly decreased level of family support (<italic>p</italic>&#x2009;&#x003C;&#x2009;.001) in comparison to the non-SGM respondents, and this in turn is associated with significantly increased levels of depression (<italic>p</italic>&#x2009;&#x003D;&#x2009;.003), post-traumatic stress disorder symptoms (<italic>p</italic>&#x2009;&#x003D;&#x2009;.013), higher levels of worries related to Covid-19 pandemic (<italic>p</italic>&#x2009;&#x003C;&#x2009;.001) and grief related to the pandemic (<italic>p</italic>&#x2009;&#x003D;&#x2009;.032) among the sexual minority individuals than among the non-SGM individuals. Moreover, the mandate of staying at home due to quarantine had a more debilitating effect on the mental health of the minority group (<xref ref-type="bibr" rid="B85">85</xref>, <xref ref-type="bibr" rid="B86">86</xref>). Gato et al. (<xref ref-type="bibr" rid="B7">7</xref>) noted that individuals staying at home might be experiencing elevated risks of depression and anxiety, provided the fact that the associated home climate is hostile and non-affirming of the sexual identity of the individuals. Hence, staying at home although, provided a sense of security to most individuals during the pandemic, for the SGM group the response was different, owing to the associated discrimination and parental rejections. These findings were also confirmed by Salerno et al. (<xref ref-type="bibr" rid="B8">8</xref>). The researchers noted that sexual minority youths who went back to their parental house during the post-onset of the pandemic experienced significantly higher levels of psychological distress and decreased well-being in comparison to the others who were already staying before, the reasons being the same.</p>
</sec>
<sec id="s3h"><title>COVID-19 stress and disordered eating</title>
<p>Covid-19 stress is often associated with weight stigmatizing in social media messaging (<xref ref-type="bibr" rid="B87">87</xref>), which in turn can contribute to increased perceptions of weight gain and disordered eating behavior (<xref ref-type="bibr" rid="B88">88</xref>, <xref ref-type="bibr" rid="B89">89</xref>). Disordered eating behavior among sexual minority groups is a common problem and is often associated with negative experiences of stigma and discrimination (<xref ref-type="bibr" rid="B90">90</xref>&#x2013;<xref ref-type="bibr" rid="B92">92</xref>). Such problem behavior is considered a coping mechanism for minority individuals in the face of minority stress (<xref ref-type="bibr" rid="B33">33</xref>).</p>
<p>The current review also found that Covid-19 stress among SGM individuals is associated with elevated risks of disordered eating behavior and increased perception of weight gain among them (<xref ref-type="bibr" rid="B33">33</xref>). Hart et al. (<xref ref-type="bibr" rid="B49">49</xref>) noted that most of their study participants reported an increase in the urge and frequency of engaging in disordered eating behavior. Moreover, they found an association between disordered eating behavior and increased levels of psychological stress due to Covid-19 and the quality of relationships at home and non-acceptance of one&#x0027;s sexual identity by family members. Tabler et al. (<xref ref-type="bibr" rid="B33">33</xref>) noted that nearly one out of three participants presented clinically significant symptoms of disordered eating.</p>
</sec>
<sec id="s3i"><title>Problem drinking and substance abuse associated with COVID-19 stress</title>
<p>Sexual and gender minority individuals are at an increased level of abusing substances and alcohol in comparison to non-SGM individuals even before the onset of the pandemic (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B93">93</xref>&#x2013;<xref ref-type="bibr" rid="B95">95</xref>). More often, negative experiences of psycho-social stresses contribute to heavy alcohol consumption and other substance abuse among SGM individuals, which in turn leads to elevated risks of psychological distress (<xref ref-type="bibr" rid="B96">96</xref>, <xref ref-type="bibr" rid="B97">97</xref>).</p>
<p>In the present review, Goodyear et al. (<xref ref-type="bibr" rid="B50">50</xref>) reported increased alcohol use among 24.5&#x0025; of the study participants and increased cannabis use among 18.5&#x0025; of the respondents due to the pandemic stress. furthermore, they reported that higher levels of alcohol consumption were associated with poor coping skills, and lower levels of self-rated psychological health, while increased use of cannabis was associated with suicidal thoughts. Along the same line, Fish et al. (<xref ref-type="bibr" rid="B5">5</xref>) reported that in comparison to heterosexual men, gay men, and bisexual men experienced a significant decrease in psychological health, quality of life, higher levels of stress, feelings of loneliness, and alcohol consumption. Lesbian individuals also reported significantly higher levels of alcohol consumption in their study.</p>
</sec>
</sec>
<sec id="s4" sec-type="discussion"><title>Discussion</title>
<p>The present review had two objectives; first, to explore the impact of Covid-19 stress on the psychological health of the sexual minority group, and, second, to identify the stressors associated with the Covid-19 pandemic. For the same, 16 studies were selected following the PRISMA framework from among an initial pool of 208 studies. The studies were all selected strategically following nine different inclusion criteria. A detailed review of the studies helped fulfill the two objectives of the current study.</p>
<p>All sixteen studies reported an elevated risk of depression and anxiety symptoms among sexual minority individuals. The heightened symptoms of depression and anxiety were also found to be associated with loneliness (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B39">39</xref>), symptoms of post-traumatic stress disorder, worries related to the Covid-19 severity and related grief (<xref ref-type="bibr" rid="B32">32</xref>), poor quality of relationships (<xref ref-type="bibr" rid="B49">49</xref>), suicidal thoughts (<xref ref-type="bibr" rid="B50">50</xref>), substance use and alcohol abuse (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B50">50</xref>), and disordered eating behavior (<xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B49">49</xref>). Higher levels of depression and anxiety are more often experienced by non-working, European SGM youths, who are more susceptible to feeling uncomfortable, isolated, and emotionally impacted by the pandemic (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>) and among transgender or gender-diverse women who are full-time students (<xref ref-type="bibr" rid="B31">31</xref>). Urz&#x00FA;a et al. (<xref ref-type="bibr" rid="B59">59</xref>) studied the differential impact of Covid-19 stress among the different subgroups of SGM individuals as well. Their findings suggested a higher occurrence of depressive symptoms among bisexual and lesbian women in comparison to bisexual and gay men.</p>
<p>In most cases, the incidences of worsened psychological health and problem behavior were found to be associated with lower levels of perceived social support, discrimination, hostile family climate, and non-affirming of one&#x0027;s sexual identity (<xref ref-type="bibr" rid="B5">5</xref>&#x2013;<xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B32">32</xref>&#x2013;<xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B46">46</xref>). Such findings are in line with other similar studies reporting the role of psychosocial factors in mediating the worsened psychological health among SGM individuals (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B17">17</xref>).</p>
<p>A second objective of the review was to identify the stressors associated with the pandemic. The present review identified two potential stressors, strong enough to produce a debilitating impact on the mental health of the sexual and gender minority population. First, the present review noted the importance of perceived social support as a buffer against the ill effects of the minority stressors like stigma, discrimination, violence, non-acceptance, and rejection (<xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B46">46</xref>). Lower levels of perceived social support (emotional, tangible, affectionate, and positive social interactions) are associated with poor psychological health of SGM individuals. This finding is particularly important since this validates the hypothesis of &#x201C;Social Support as a buffer against stress&#x201D; in the Covid-19 context. Second, the review identified the importance of family support in mediating psychological well-being among SGM individuals. The findings revealed that decreased level of family support is associated with increased symptoms of depression, anxiety, post-traumatic stress disorder, and higher levels of worries and grief related to the Covid-19 pandemic (<xref ref-type="bibr" rid="B32">32</xref>). Moreover, similar effects on mental health resulted from a hostile family environment and non-acceptance of one&#x0027;s own sexual identity by the family (<xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B8">8</xref>). Hence, a lack of family support can be considered a potential stressor in the Covid-19 context.</p>
</sec>
<sec id="s5"><title>Implications of the study</title>
<p>Although there has not been any dearth of studies reporting the negative impact of the Covid-19 pandemic on the mental health of the sexual and gender minority group, a review of the articles was lacking in this post-Covid period. A review helps gain new insight into an ongoing event or situation. After the onset of Covid-19, there have been several reviews done, focusing on different aspects of the impact of Covid-19 stress (<xref ref-type="bibr" rid="B98">98</xref>&#x2013;<xref ref-type="bibr" rid="B101">101</xref>). However, only a handful of reviews focused on the mental health of the sexual and gender minority group (<xref ref-type="bibr" rid="B101">101</xref>&#x2013;<xref ref-type="bibr" rid="B103">103</xref>).</p>
<p>Overall, the present review highlighted the importance of studying and considering the mental health outcomes of Covid-19 stress for the sexual and gender minority group. Some of the previously done reviews also underlined the same, although in a different context, for instance, (<xref ref-type="bibr" rid="B101">101</xref>) studied the application of psychotherapy for the minority population in the Covid-19 context. However, the present review not only summarized the negative impact of the pandemic stress on the psychological health of the SGM group but also identified the potential stressors and associated outcomes for the minority individuals in the Covid-19 context. This is one of the major strengths of the present review and contributes to the relevance of the study in the present context. Greater effort must be put on the part of clinical psychologists and social workers to mitigate the debilitating impact of the pandemic on the mental health of sexual and gender minority individuals. Moreover, policymakers must consider the unique impact of psychosocial factors on SGM individuals while developing any mental health policy or stating a law applicable to this population.</p>
<p>Another strength of the present review lies in the fact that the review included studies of several different populations, mostly representing the European, British, and US populations. One of the studies also included the population from Hong Kong (<xref ref-type="bibr" rid="B47">47</xref>), providing a representation from one of the Asian countries. This is particularly important because this points to the fact that the impact of Covid-19 stress on the psychological health of the SGM group remains indifferent across different cultures, societies, and even continents.</p>
<p>The timing of the review is also of particular importance and has implications. The present review has been done at such a time when most countries have overcome the three waves of the pandemic and the impact of the pandemic on the mental health of people around the globe is more or less explored. All the reviews done previously (during the ongoing first wave or second wave) could only provide a partial, and in certain cases, an incomplete picture of the scenario. The present review is well-timed and provided a well-representation of the situation across different continents, countries, and cultures. Hence, the findings have wider implications for clinical psychologists, social workers, and policymakers around the globe.</p>
</sec>
<sec id="s6"><title>Limitations and future research</title>
<p>Like any other research, the present review also has some limitations. First, the present study included SGM individuals mostly belonging to the young adult age group. However, the pandemic has also hugely affected the SGM older adults and individuals with some terminal conditions like HIV infected population. But researches reporting this impact were beyond the purview of the present review, the reason being that such studies are quite less in number and hence do not qualify for a full-fledged review. Future research should consider an elaborate review of such issues in the context of the Covid-19 pandemic. Second, almost all the studies included studied the European, Canadian, American, and British populations. Only one Asian study done on the Hong Kong population could be included. It would have been better if more studies from the Asian continent and African continents could be included in the present review. A major reason for this has been a lack of empirical studies done on the SGM population of Asian or African countries during the pandemic. This can be attributed to the limitations in the healthcare facilities and research infrastructure of these developing societies, in comparison to western societies. Future research should take note of this issue and consider having more research focusing on SGM individuals in developing societies.</p>
</sec>
<sec id="s7" sec-type="conclusions"><title>Conclusion</title>
<p>The present study reported a systematic review of sixteen studies focusing on the impact of Covid-19 stress on the mental health of the sexual and gender minority population. The review of the studies reported the association between the negative effect of the pandemic stress and higher levels of psychological distress, symptoms of depression, anxiety, loneliness, problem drinking, and disordered eating behavior among minority individuals. Moreover, the study also identified the lack of perceived social support and family support in mediating the inverse relationship between increased Covid-19 stress and decreased psychological health of the sexual and gender minority individuals. Overall, the review provided a detailed understanding and newer insights into the mental health issues of the sexual and gender minority group in the context of the Covid-19 pandemic.</p>
</sec>
</body>
<back>
<sec id="s8" sec-type="data-availability"><title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s.</p>
</sec>
<sec id="s9"><title>Author contributions</title>
<p>Both the authors contributed to the development of the idea. The database search and filtering were done by SD. Both SD and TM did the review of the articles for the final selection as per the inclusion criteria. The manuscript was primarily drafted by SD with inputs and suggestions from TM. All authors contributed to the article and approved the submitted version.</p>
</sec>
<sec id="s10" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s11" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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