<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" "archivearticle.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="expression-of-concern">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Genet.</journal-id>
<journal-title>Frontiers in Genetics</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Genet.</abbrev-journal-title>
<issn pub-type="epub">1664-8021</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fgene.2016.00202</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Genetics</subject>
<subj-group>
<subject>General Commentary</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Expression of Concern: Enhancement of RNA-directed DNA methylation of a transgene by simultaneously downregulating a ROS1 ortholog using a virus vector in <italic>Nicotiana benthamiana</italic></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<collab>Frontiers in Genetics</collab>
<xref ref-type="author-notes" rid="fn001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/61800/overview"/>
</contrib>
</contrib-group>
<author-notes>
<fn fn-type="edited-by"><p>Edited and reviewed by: Richard A. Jorgensen, University of Arizona, USA</p></fn>
<fn fn-type="corresp" id="fn001"><p>&#x0002A;Correspondence: Frontiers in Genetics <email>genetics.editorial.office&#x00040;frontiersin.org</email></p></fn>
<fn fn-type="other" id="fn002"><p>This article was submitted to Plant Genetics and Genomics, a section of the journal Frontiers in Genetics</p></fn></author-notes>
<pub-date pub-type="epub">
<day>07</day>
<month>11</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection">
<year>2016</year>
</pub-date>
<volume>7</volume>
<elocation-id>202</elocation-id>
<history>
<date date-type="received">
<day>02</day>
<month>11</month>
<year>2016</year>
</date>
<date date-type="accepted">
<day>02</day>
<month>11</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2016 Frontiers in Genetics.</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Frontiers in Genetics</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<related-article id="RA1" related-article-type="object-of-concern" journal-id="Front Genet" journal-id-type="nlm-ta" vol="4" page="44" xlink:href="23565118" ext-link-type="pubmed">An expression of concern on <article-title>Enhancement of RNA-directed DNA methylation of a transgene by simultaneously downregulating a ROS1 ortholog using a virus vector in <italic>Nicotiana benthamiana</italic></article-title> by Otagaki, S., Kasai, M., Masuta, C., and Kanazawa, A. (2013). Front. Genet. 4:44. doi: <object-id>10.3389/fgene.2013.00044</object-id></related-article> 
<counts>
<fig-count count="0"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="0"/>
<page-count count="1"/>
<word-count count="1810"/>
</counts>
</article-meta>
</front>
<body>
<p>With this notice, Frontiers states its concerns about the reliability of some of the findings of the article &#x0201C;Enhancement of RNA-directed DNA methylation of a transgene by simultaneously downregulating a ROS1 ortholog using a virus vector in <italic>Nicotiana benthamiana</italic>&#x0201D; published on 2nd April 2013.</p>
<p>In full accordance with Frontiers procedures, following an investigation directed by our Chief Editors, Dr. David Allison and Dr. Richard Jorgensen, the authors are currently performing further experiments to address these issues.</p>
<p>The situation will be updated as soon as the investigation is complete.</p>
</body>
</article>