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<journal-id journal-id-type="publisher-id">Front. Food. Sci. Technol.</journal-id>
<journal-title>Frontiers in Food Science and Technology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Food. Sci. Technol.</abbrev-journal-title>
<issn pub-type="epub">2674-1121</issn>
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<publisher-name>Frontiers Media S.A.</publisher-name>
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<article-id pub-id-type="publisher-id">1388461</article-id>
<article-id pub-id-type="doi">10.3389/frfst.2024.1388461</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Food Science and Technology</subject>
<subj-group>
<subject>Review</subject>
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</article-categories>
<title-group>
<article-title>Exploration of novel eco-friendly techniques to utilize bioactive compounds from household food waste: special reference to food applications</article-title>
<alt-title alt-title-type="left-running-head">Siddique et al.</alt-title>
<alt-title alt-title-type="right-running-head">
<ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/frfst.2024.1388461">10.3389/frfst.2024.1388461</ext-link>
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<contrib contrib-type="author" corresp="yes">
<name>
<surname>Siddique</surname>
<given-names>Farzana</given-names>
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<xref ref-type="aff" rid="aff1">
<sup>1</sup>
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<xref ref-type="corresp" rid="c001">&#x2a;</xref>
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<sup>&#x2020;</sup>
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<surname>Ali</surname>
<given-names>Zoha</given-names>
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<sup>1</sup>
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<xref ref-type="fn" rid="fn1">
<sup>&#x2020;</sup>
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<contrib contrib-type="author">
<name>
<surname>Arshad</surname>
<given-names>Muhammad</given-names>
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<xref ref-type="aff" rid="aff2">
<sup>2</sup>
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<xref ref-type="corresp" rid="c001">&#x2a;</xref>
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<sup>&#x2020;</sup>
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<name>
<surname>Mubeen</surname>
<given-names>Kinza</given-names>
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<xref ref-type="aff" rid="aff1">
<sup>1</sup>
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<xref ref-type="fn" rid="fn1">
<sup>&#x2020;</sup>
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<surname>Ghazala</surname>
<given-names>Afsheen</given-names>
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<sup>1</sup>
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<sup>&#x2020;</sup>
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<aff id="aff1">
<sup>1</sup>
<institution>Institute of Food Science and Nutrition</institution>, <institution>University of Sargodha</institution>, <addr-line>Sargodha</addr-line>, <country>Pakistan</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Department of Zoology</institution>, <institution>University of Sargodha</institution>, <addr-line>Sargodha</addr-line>, <country>Pakistan</country>
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<author-notes>
<fn fn-type="edited-by">
<p>
<bold>Edited by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1715160/overview">Waseem Khalid</ext-link>, Government College University, Pakistan</p>
</fn>
<fn fn-type="edited-by">
<p>
<bold>Reviewed by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2632581/overview">Muhammad Abdul Rahim</ext-link>, Times Institute Multan, Pakistan</p>
<p>
<ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2230021/overview">Hyrije Koraqi</ext-link>, University for Business and Technology (UBT), Albania</p>
</fn>
<corresp id="c001">&#x2a;Correspondence: Farzana Siddique, <email>farzana.siddique@uos.edu.pk</email>; Muhammad Arshad, <email>arshad.sarwar@uos.edu.pk</email>
</corresp>
<fn fn-type="other" id="fn1">
<label>
<sup>&#x2020;</sup>
</label>
<p>ORCID: Farzana Siddique, <ext-link ext-link-type="uri" xlink:href="https://orcid.org/0000-0002-6610-2494">https://orcid.org/0000-0002-6610-2494</ext-link>; Zoha Ali, <ext-link ext-link-type="uri" xlink:href="https://orcid.org/0009-0009-0495-6011">https://orcid.org/0009-0009-0495-6011</ext-link>; Muhammad Arshad, <ext-link ext-link-type="uri" xlink:href="https://orcid.org/0000-0001-5501-6956">https://orcid.org/0000-0001-5501-6956</ext-link>; Kinza Mubeen, <ext-link ext-link-type="uri" xlink:href="https://orcid.org/0009-0009-5173-0250">https://orcid.org/0009-0009-5173-0250</ext-link>; Afsheen Ghazala, <ext-link ext-link-type="uri" xlink:href="https://orcid.org/0009-0003-8803-7368">https://.org/0009-0003-8803-7368</ext-link>
</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>03</day>
<month>05</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>4</volume>
<elocation-id>1388461</elocation-id>
<history>
<date date-type="received">
<day>19</day>
<month>02</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>27</day>
<month>03</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2024 Siddique, Ali, Arshad, Mubeen and Ghazala.</copyright-statement>
<copyright-year>2024</copyright-year>
<copyright-holder>Siddique, Ali, Arshad, Mubeen and Ghazala</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<p>The issue of household waste management is a pervasive global concern. Household waste, especially food waste, comprises a reservoir of compounds with potential economic value, among which bioactive compounds prominently feature. These bioactive compounds, derived from natural chemical substances inherent in waste from animal and protein sources, offer nutritional benefits. Extracted bioactive compounds find versatile applications in various domains including textiles, cosmetics, nutraceuticals, food additives, and the agriculture sector. The extraction of such compounds is achieved through a diversity of techniques, including conventional methods alongside non-conventional green approaches such as extraction methods using enzymes, microwaves, or supercritical fluids. However, there is an increasing need for green and sustainable approaches, leading to bioactive-rich extracts with low environmental impact. This review thoroughly summarizes the origins, kinds, and characteristics of bioactive chemicals found in food waste. It also addresses the most promising and innovative methodologies for the recovery of functional bioactive compounds from waste materials that have been published recently. New technologies can meaningfully manage materials from household food waste. These bioactive compounds are valuable for food industrial applications.</p>
</abstract>
<abstract abstract-type="graphical">
<title>Graphical Abstract</title>
<p>
<graphic xlink:href="FRFST_frfst-2024-1388461_wc_abs.tif" position="anchor"/>
</p>
</abstract>
<kwd-group>
<kwd>waste management</kwd>
<kwd>food waste</kwd>
<kwd>biological active compounds</kwd>
<kwd>value-added products</kwd>
<kwd>waste valorization</kwd>
<kwd>phenolic compounds</kwd>
<kwd>extraction</kwd>
<kwd>artificial intelligence</kwd>
</kwd-group>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Food Packaging and Preservation</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1">
<title>1 Introduction</title>
<p>Any item that is discarded from the home environment as part of residents&#x2019; regular activities is referred to as &#x201c;household waste&#x201d; or &#x201c;domestic garbage&#x201d;. It comprises significant portion of municipal solid waste (MSW) and is made up of a variety of materials including glass, metal, paper, plastic, food scraps, and textile fragments. Over 60 tons of rubbish are produced every second in the world&#x2019;s households, amounting to two billion tons of waste annually (<xref ref-type="bibr" rid="B122">Maalouf and Mavropoulos, 2023</xref>). The collection, transportation, and treatment of household garbage are a global issue (<xref ref-type="bibr" rid="B141">Mostaghimi and Behnamian, 2023a</xref>). Earlier studies have established the correlation between trash generation and population size as well as average income or level of living. The quantity and composition of trash can also be impacted by variables that include the environment, ways of life, levels of education, cultural and religious views, and public and social attitudes (<xref ref-type="bibr" rid="B250">Yu et al., 2023</xref>).</p>
<p>Food waste (FW) comprises a significant portion of household waste and is defined by the Food and Agriculture Organization of the United Nations (FAO) as food that is produced in smaller quantities or of greater superiority as a result of choices and actions made by food vendors, convenience stores, and consumers (<xref ref-type="bibr" rid="B214">Poonam Sharma et al., 2021a</xref>; <xref ref-type="bibr" rid="B49">Delgado, Rodriguez, and Staszewska, 2023</xref>). According to FAO data from 2019 and a UN Environment Programme Food Waste Index study, almost 14% of the world&#x2019;s food, valued at $400 billion annually, is wasted post-harvest until it reaches stores, and 17% more is wasted by consumers, primarily in households and retail establishments (<xref ref-type="bibr" rid="B229">Tanyanyiwa and Tongowona, 2023</xref>). A third of the world&#x2019;s annual food production manifests as FW, which could serve 1.26 billion malnourished people (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). Inappropriate food waste management and disposal errors can have serious environmental consequences. An estimated 3.3 billion tons of carbon dioxide equivalent is released, due to insufficient handling of FW, into the environment annually, accounting for 8% of all human greenhouse gas emissions (<xref ref-type="bibr" rid="B29">Bhatia et al., 2023</xref>). Food valorization is an innovative approach to reducing waste and providing new economic opportunities by producing value-added goods based on the bioactive ingredients of foods. These beneficial substances, which also add value to the products, include polyphenols, vitamins, minerals, and prebiotics (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). Utilizing FW&#x2019;s ability to extract these molecules may open the door to the development of premium, functional food ingredients, cosmetics, and nutritional supplements. This method seeks to lessen FW and promote creative revenue streams, in addition to aiding the development of a circular economy. It is crucial to consider the accessibility of these leftovers through time, their techno-economic prospect, and the environmental evaluation of profit and costs based on their life span to assure the sustainability of the environment and economy of future FW valorization (P. <xref ref-type="bibr" rid="B190">Roy et al., 2023</xref>).</p>
<p>This paper aims to provide a comprehensive overview of the various types of household FW commonly encountered from fruit, vegetables, cereals, pulses, and dairy. Valuable bioactive compounds like polyphenols, dietary fibers, proteins, vitamins, and minerals are extracted from these FWs by different extraction techniques. The potential applications of biologically active compounds in the food sector include food additives, nutraceuticals, and single cell proteins. Feasible conventional and nonconventional methods along with using AI and robotics for transforming FW into value-added products are also explored here. Moreover, this review offers recommendations for sustainability concerns in waste valorization and directions for future research on improving the utilization of FW, as well as stimulating interest in its conversion and reuse.</p>
</sec>
<sec id="s2">
<title>2 Traditional methods to manage household waste</title>
<p>Due to their extreme heterogeneity, household or municipal wastes must first be properly sorted and fractionated before undergoing any significant treatment. According to a number of research findings, households account for 50%&#x2013;80% of solid trash produced in developing nations, with markets and commercial zones accounting for the another 10%&#x2013;15% of municipal waste (S. <xref ref-type="bibr" rid="B98">Khan et al., 2022</xref>). These waste materials, encompassing garden waste, kitchen waste, plastic cans and bags, timber, metallic waste, cardboard, synthetic rubbers, animal hides, power cells, inert compounds, fabric waste, paint containers, building debris, and numerous other indeterminate items, necessitate a sorting and separation process to deliver essential data on the quality of sorting for any prospective application (M. <xref ref-type="bibr" rid="B217">Singh, Singh, and Singh, 2024</xref>). This process is a crucial step in solid waste management. Traditional techniques of food waste (FW) management encompass animal feeding, landfilling, composting, incineration, combustion, and similar measures (<xref ref-type="bibr" rid="B252">Zhu et al., 2023</xref>). A hierarchy of recommended waste management techniques is provided by the EC&#x2019;s waste management plan. The five steps of waste management, from most to least preferred, are avoiding waste generation, reusing materials, recycling materials, recovering energy from waste, and safely disposing of waste (<xref ref-type="bibr" rid="B141">Mostaghimi and Behnamian, 2023a</xref>). These methods lessen the production of waste, increase resource efficiency, preserve a non-ecofriendly energy mix, develop new markets and businesses, and lessen risks to human health and the environment. Overall, the hierarchy directs waste management procedures and promotes the use of more ecologically friendly and sustainable methods (<xref ref-type="bibr" rid="B233">Teng et al., 2023</xref>). Centralized waste management systems have two main weaknesses: the need to frequently transport waste over long distances, and the difficulty of sorting waste at large plants (<xref ref-type="bibr" rid="B26">Bernat, 2023</xref>). Home waste treatment can facilitate energy and monetary savings by circumventing the challenges of extensive waste management systems (<xref ref-type="bibr" rid="B89">Jayanandini, 2023</xref>). Various waste management methods may be implemented in a home, contingent on the amount of space, time, and financial resources available. Regretfully, the majority of these&#x2014;open burning, anaerobic digestion, and composting&#x2014;only permit the processing of organic waste (<xref ref-type="bibr" rid="B80">Hui et al., 2023</xref>). Composting is the most used waste management technique in homes. There are many different methods and tools available, ranging from the most affordable homemade boxes to sophisticated yet rather costly automated composters. The process of composting gives the soil the chance to absorb the nutrients included in the biomass and gives access to high-quality fertilizer. However, it requires time (<xref ref-type="bibr" rid="B246">Waqas et al., 2023</xref>). In addition, microbes eat the energy included in the waste, so it is lost from the viewpoint of the householders (<xref ref-type="bibr" rid="B92">Jouhara et al., 2017</xref>). Energy recovery from methane combustion is possible by anaerobic digestion, but this requires substantial investment and a sizable area to install the digester. It may also only be readily introduced in warm climates as microbes need a certain temperature to thrive. The digester must be heated in cold and mild temperatures, which presents some challenges. The homeowner receives useful fertilizer as a byproduct; organic waste contains nutrients that may be recycled (<xref ref-type="bibr" rid="B68">Glasser, 2023</xref>; <xref ref-type="bibr" rid="B105">Kumar et al., 2023</xref>). Another popular technique for handling domestic garbage is combustion to create heat, which happens between the fuel and the oxidant. The fuel may be solid, liquid, or gaseous. Fuel and oxidants undergo chemical reactions when ignited, and eventually the process becomes self-sustaining due to the heat produced by the reactions (<xref ref-type="bibr" rid="B112">Liang, 2023</xref>; <xref ref-type="bibr" rid="B155">Obi et al., 2023</xref>). Contemporary nations forbid the open burning of mixed garbage due to the significant harm it causes both the environment and public health (<xref ref-type="bibr" rid="B161">Oyebode, 2024</xref>). In certain situations, biomass burning could make sense, provided the right circumstances are met. A sizable space is required for the disposal of garbage. Finding a &#x201c;free&#x201d; location is challenging&#x2014;not just in suburban areas but also away from populated areas (<xref ref-type="bibr" rid="B199">Santos and Mendes, 2024</xref>). The lengthening of trash transportation routes to disposal sites results in higher waste management expenses. A contemporary landfill is a costly, intricate technological structure that spans several dozen hectares and is just a few tens of meters deep. The landfill&#x2019;s base is made up of many layers in addition to the earth, and leachate neutralization and collection are required (<xref ref-type="bibr" rid="B237">Un, 2023</xref>). Treatment is then required for the collected leachate. Perforated 0.7-meter-diameter ferrous-beton rings are used to attach vertical gas wells (<xref ref-type="bibr" rid="B170">Petruk et al., 2016</xref>). Like composting, controlled incineration facilities are used for incineration. Contemporary incinerators include large stacks and combustion chambers that are purpose built. To achieve full combustion, they must supply air, high combustion temperatures, extended residence durations, and effective waste mixing (<xref ref-type="bibr" rid="B185">Reich et al., 2023</xref>). To comply with pollution regulations, they also feature effective flue gas cleaning systems. The Waste Incineration Directive of the EU has specifications for them (<xref ref-type="bibr" rid="B173">Dal Pozzo, Capecci, and Cozzani, 2023</xref>). The waste categories that are burned include municipal solid waste (MSW), industrial waste, toxic waste, clinical waste, and sludge from sewage treatment plants (<xref ref-type="bibr" rid="B156">Ogunkunle et al., 2024</xref>).</p>
<p>Although these conventional techniques may result in the loss of important biomaterials recovered from food waste streams, they may tangentially boost economic gains. It was projected that traditional and unplanned FW management would result in the depletion of critical resources, such as nutrients and bioactive substances, as well as negative environmental effects. To comply with international regulatory frameworks for food security, integrated and developing home and FW management has been supported (<xref ref-type="bibr" rid="B202">Sarker et al., 2024a</xref>).</p>
</sec>
<sec id="s3">
<title>3 Recent trends of household waste management</title>
<p>The integration of artificial intelligence (AI), robotics, the internet of things (IoT), and big data and analytics into waste management has revolutionized the sector (<xref ref-type="bibr" rid="B182">Rane, 2023</xref>). AI enhances operational efficiency by automating waste management processes, such as scheduling pickups, trucking, and sorting. Robotics, powered by detectors, machine vision, and AI, automate trash segregation operations and ensure material-specific disposal (<xref ref-type="bibr" rid="B222">Sivashanmugam et al., 2023</xref>). Timely waste collection and disposal is made possible by IoT-based waste management with real-time waste bin tracking. Big data insights into location and bin emptying frequency enable waste collection businesses to distinguish between different forms of waste and guarantee timely collection (<xref ref-type="bibr" rid="B135">Melakessou et al., 2020</xref>). Cutting-edge recycling technologies improve waste stream quality and operating efficiency. Examples include material scanners and autonomous waste-picking devices. Developments in decomposition technologies make use of organic materials&#x2019; natural breakdown processes to nourish the soil with healthy nutrients and stop soil erosion (<xref ref-type="bibr" rid="B180">Rajput et al., 2024</xref>). Furthermore, the process of waste management has been greatly enhanced by the incorporation of blockchain technology, bringing transparency and traceability to the waste management value chain to enable responsible waste management. These advances, coupled with the principles of the circular economy which ensure minimum waste by reusing and repurposing existing products, are paving the way for a more sustainable future (<xref ref-type="bibr" rid="B75">Gupta and Shankar, 2024</xref>; <xref ref-type="bibr" rid="B96">Kandpal et al., 2024</xref>).</p>
<p>The management of household waste by its valorization in the production of biofuels, biomethane production, bio-alcohol production, biohydrogen production, production of bio-materials, animal feed, and the recovery of value-added components and bioactive compounds is a promising strategy for achieving sustainable and zero-waste development of the agri-food sector. Food and agri-food utilize waste byproducts for biofuel production, a significant strategy due to rising energy costs and environmental concerns (<xref ref-type="bibr" rid="B239">Venugopal, 2022</xref>). Biofuels are produced using bio-based technologies such as anaerobic digestion, aerobic digestion, and microbial fermentation (<xref ref-type="bibr" rid="B12">Anoopkumar et al., 2023</xref>). Adsorption, which is an economical and environmentally beneficial process, is utilized for wastewater treatment, with lignocellulosic waste products acting as substitutes for activated carbon synthesis (H. H. <xref ref-type="bibr" rid="B206">Shah et al., 2023</xref>). Extracted components from food waste (FW) containing sugars, proteins, fibers, pectin, lipids, polysaccharides, taste compounds, and phytochemicals are employed as food additives, nutraceuticals, pharmaceuticals, and cosmetics. This increases food availability, extends shelf life, and minimizes landfill waste (<xref ref-type="bibr" rid="B13">Aqilah et al., 2023</xref>). Polymers made from renewable organic sources, known as &#x201c;bio-based polymers&#x201d;, diminish reliance on fossil fuels and are produced from agro-industrial waste through combined fermentation and enzymatic processes. Enzymes, produced from these wastes, have significant industrial applications due to their high specificity (J. <xref ref-type="bibr" rid="B248">Yadav et al., 2023</xref>). The dried biomass of diverse microbial species&#x2014;single-cell protein (SCP)&#x2014;can serve as a protein supplement. SCP is produced by microorganisms that convert low-protein organic substrates into high-protein products (U. <xref ref-type="bibr" rid="B208">Shah and Hajoori, 2022</xref>). The aerobic degradation of FW produces pathogen-free bio-fertilizers and soil conditioners, reducing solid waste handling and disposal burdens and providing social and environmental benefits (<xref ref-type="bibr" rid="B116">Lirikum et al., 2022</xref>). The success of this valorization procedure is affected by variables such as temperature, ventilation, moisture levels, pH, carbon-to-nitrogen ratio, particle dimensions, and level of compaction. However, the viability of composting relies on the greenhouse-gas emissions produced during the decomposition of organic matter (<xref ref-type="bibr" rid="B18">Azis et al., 2022</xref>).</p>
</sec>
<sec id="s4">
<title>4 Sources of household food waste generation</title>
<sec id="s4-1">
<title>4.1 Cereals and pulses</title>
<p>Cereals, which include rice and grains such as wheat, rye, millet, corn, and buckwheat are an important part of the food pyramid and serve as the primary source of energy (M. A. <xref ref-type="bibr" rid="B207">Shah, Sunooj, and Mir, 2023</xref>). Throughout the processing phase, cereals and legumes produce by-products such as germ and bran. The residual cereal matter in malt processing is generally considered a byproduct and is commonly disposed of as refuse. Rice husks can be used for a variety of purposes, including building materials, nutrients, substrates for decomposition techniques, and producing fiber and feedstock (R. <xref ref-type="bibr" rid="B249">Yadav et al., 2020</xref>). The byproduct of barley processing contains a significantly higher quantity of vitamin E (2.7 times more) than the entire barley grain. In addition, it provides an abundance of different bioactive substances, including phenolics, phytates, and insoluble food fiber (<xref ref-type="bibr" rid="B179">Raj et al., 2023</xref>). Phenolic chemicals are also produced because of cellulase&#x2019;s enzymatic degradation of rice bran and husk. Value-added products can be produced by growing flat mushrooms, extracting pectin, and making livestock feed from the leftover shells of cocoa processing. Furthermore, it is possible to obtain a second-generation bioethanol from coconut husk (<xref ref-type="bibr" rid="B60">Freitas et al., 2021</xref>; <xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>).</p>
</sec>
<sec id="s4-2">
<title>4.2 Fruits and vegetables</title>
<p>Nutrient-rich fruit and vegetable wastes are often handled via landfill and composting, which harms the environment (<xref ref-type="bibr" rid="B221">Singha and Singha, 2024</xref>). Another strategy is hydrolyzing the cellulose and starch in these wastes to create sweet fermentables that can be used to yield alcohol and hydrogen (<xref ref-type="bibr" rid="B15">Aruwajoye et al., 2020</xref>). Innovations such as single-cell proteins, oils, pigments, polyphenols, and biofuels can be produced by microbial processing. Fermentation can also produce lactic and succinic acids (<xref ref-type="bibr" rid="B42">Chavan et al., 2022</xref>). Such strategies can maximize the resource&#x2019;s potential for sustainable use while addressing environmental issues (<xref ref-type="bibr" rid="B10">Almalki et al., 2023</xref>). <xref ref-type="fig" rid="F1">Figure 1</xref> illustrates different sources of household waste and bioactive compounds present in those waste materials.</p>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption>
<p>Sources of household food waste containing different bioactive compounds.</p>
</caption>
<graphic xlink:href="frfst-04-1388461-g001.tif"/>
</fig>
</sec>
<sec id="s4-3">
<title>4.3 Dairy</title>
<p>Worldwide, approximately 128 million tons of milk production is lost annually, attributed to factors like processing, microbial spoilage, and inadequate handling. Dairy goods, characterized by their intricate organic makeup of proteins, fats, sugars, and food supplements, are especially susceptible to spoilage and fungal contamination (<xref ref-type="bibr" rid="B165">Pantoja et al., 2022</xref>). In the manufacturing of cheese, for each kilogram of the product, 9&#xa0;kg of whey is discarded (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). The wastewater from milk processing, containing significant amounts of carbohydrates, lipids, proteins, and nitrogen concentrations of 14&#x2013;830&#xa0;mg/L, can produce substances such as nucleic acids, urea, proteins, and NO<sup>&#x2212;2</sup>, NO<sup>&#x2212;3</sup>, and NH<sup>&#x2b;4</sup> when milk proteins are dissociated. This dairy refuse, abundant in organic content, has the potential to be transformed into value-added items through microbial-facilitated methods (<xref ref-type="bibr" rid="B108">Kusmayadi et al., 2022</xref>). Filamentous fungi can also decompose the intricate carbohydrates present in dairy waste into monosaccharides, contributing to the creation of superior biomass for animal feed and single-cell proteins, deemed safe for human consumption (T. A. <xref ref-type="bibr" rid="B219">Singh et al., 2022</xref>).</p>
</sec>
<sec id="s4-4">
<title>4.4 Edible oil and fats</title>
<p>Oxidative or hydrolytic spoilage is a primary factor leading to the degradation of edible oils and their subsequent disposal (<xref ref-type="bibr" rid="B58">Fazli et al., 2022</xref>). The emergence of polar molecules in used cooking oil, such as free short-chain fatty acids, mono- and diglycerides, aldehydes, ketones, polymers, and cyclic and aromatic compounds, renders it unfit for human consumption after undergoing multiple deep-frying cycles (<xref ref-type="bibr" rid="B35">C&#xe1;rdenas et al., 2021</xref>; <xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). Historically, the oil processing industry has released its effluents into the soil and groundwater, resulting in the creation of oily films on aquatic surfaces. This has presented a significant hazard to the survival of marine organisms and caused blockages in sewage and drains due to the emulsification of organic matter, as well as oil methanization, contributing to the greenhouse effect. Nevertheless, innovative methods now exist that employ microbial cells to degrade organic substances in effluents, leading to the production of high-quality products such as bio-based zwitterionic biosurfactant (<xref ref-type="bibr" rid="B99">Khorram et al., 2023</xref>). For example, <italic>Pseudomonas aeruginosa</italic> has demonstrated the ability to generate biosurfactants, including rhamnolipid and sophorolipid, along with biodiesel production through lipase and liquid hydrocarbon biofuels (<xref ref-type="bibr" rid="B64">Gaur et al., 2022</xref>). Residues from edible oil, such as tocopherols, sterols, and squalene, are now extracted and utilized as raw materials in diverse industries, including the creation of single-cell oil/protein for food as well as in medicinal formulations and cosmetics in the form of soap stalk (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>).</p>
</sec>
<sec id="s4-5">
<title>4.5 Meat, poultry, and eggs</title>
<p>A positive strategy for utilizing byproducts from slaughterhouses involves cultivating lactic acid bacteria, which can be incorporated into probiotic goods (<xref ref-type="bibr" rid="B201">Sar et al., 2022</xref>). Slaughterhouse remnants serve as a rich reservoir of nutrients that can be harnessed to generate diverse value-added items, including biogas, hemoglobin for both food and non-food applications, biomass, and methane (<xref ref-type="bibr" rid="B204">Selvamuthukumaran, 2024a</xref>). These outputs include fish feed, fertilizers, binders, blood sausages, blood cakes, blood puddings, blood clots, and a sustainable energy substitute derived from the anaerobic digestion of wastewater (<xref ref-type="bibr" rid="B176">Purkait et al., 2023</xref>). Biodiesel has been derived from chicken manure biochar through pseudo-catalytic transesterification reactions and eggshells using homogeneous catalysts for transesterification of triglycerides with methanol. This approach holds significant promise in the development of pharmaceutical and cosmetic products (<xref ref-type="bibr" rid="B244">Wang et al., 2020</xref>).</p>
</sec>
<sec id="s4-6">
<title>4.6 Seafoods and aquatic life</title>
<p>Oceanic ecosystems, contributing approximately 20% of the global food supply, produce substantial byproducts owing to the suboptimal quality of marine organisms; only 40% of protein from crustaceans and 75% of tuna fillets are deemed usable (<xref ref-type="bibr" rid="B5">Ahern et al., 2021</xref>). This byproduct, encompassing materials like shrimp exoskeletons, crab carapaces, prawn remnants, fish scales, and the skeletal structures of crustaceans, is abundant in valuable compounds such as amino acids, cellulose, and calcium carbonate (<xref ref-type="bibr" rid="B123">Machineni, 2023</xref>). Traditional disposal methods can cause environmental harm, and chitin can contribute to contamination. Therefore, a biological remedy for this waste is crucial for environmental protection and bioeconomic revenue generation. Valuable substances like astaxanthin, a pigment found in crustacean waste, and chitosan, a biopolymer with antibacterial properties, can be derived from this waste (S. <xref ref-type="bibr" rid="B220">Singh et al., 2022</xref>). Furthermore, marine-derived glycosaminoglycans are higher quality than those obtained from land-based sources. Enzymatic hydrolysis can transform the waste products of seafood processing into compounds with biological activity and health benefits (<xref ref-type="bibr" rid="B162">Ozogul et al., 2021</xref>; V. C; <xref ref-type="bibr" rid="B192">Roy VikashChandra et al., 2023</xref>).</p>
</sec>
</sec>
<sec id="s5">
<title>5 Bioactive compounds in food waste</title>
<p>Food and natural substances contain potent components and bioactive compounds that can improve health outcomes (<xref ref-type="bibr" rid="B133">Mateus et al., 2023</xref>). For instance, edibles can provide dietary fiber, vitamins, minerals, polyphenols, and other health-promoting substances (<xref ref-type="bibr" rid="B110">Kusumasari et al., 2024</xref>). The identification and extraction of these bioactive molecules enables the development of novel functional ingredients and nutritional supplements, which reduce waste and enhance sustainability. The identification and extraction of these bioactive molecules enable the development of novel functional ingredients and nutritional supplements which reduce waste and enhance sustainability. (<xref ref-type="bibr" rid="B125">Mahmud et al., 2024</xref>).</p>
<sec id="s5-1">
<title>5.1 Polyphenols</title>
<p>Health-beneficial polyphenols can be extracted from food waste (FW). Plants require phenolic compounds for a variety of molecular and physiological processes, including signaling, defense mechanisms, auxin transport mediation, and scavenging of free radicals. These substances have anti-inflammatory, antibacterial, antioxidant, and anticarcinogenic qualities that help human health in addition to greatly enhancing the health of plants. In plants, phenolic compounds act as UV filters, signal compounds, attractants, structural polymers, antioxidants, and defensive response chemicals (<xref ref-type="bibr" rid="B102">Koraqi et al., 2023</xref>). Apple peel and other fruit waste contain flavonoids such as quercetin glycosides which have antioxidant properties similar to vitamin C (<xref ref-type="bibr" rid="B50">Dhakal et al., 2024</xref>; Hamauzu 2024). Carrots have high anthocyanin content and strong antioxidant properties, which may enhance gastrointestinal health and lower the risk of cardiovascular disease (<xref ref-type="bibr" rid="B86">Ikram et al., 2024</xref>). Pomelo peel, often discarded after its fruit is consumed, is rich in flavonoids and phenolic acids (Abiq et al., 2024). Grape skin and seed are the main sources of resveratrol, a renowned antioxidant (Almanza-Oliveros et al., 2024). In addition, cranberry pomace, the neglected byproduct of cranberries, has beneficial polyphenolic compounds such as anthocyanins and proanthocyanidins (<xref ref-type="bibr" rid="B30">Boateng and Clark, 2024</xref>). Blueberry byproducts, including peel, pulp, seed, and stems, have higher levels of phenolic compounds, especially anthocyanins, than the fruit&#x2019;s flesh (<xref ref-type="bibr" rid="B46">Cruz et al., 2024</xref>; <xref ref-type="bibr" rid="B120">Luo, 2024</xref>). Lastly, soluble coffee production waste contains about 6% polyphenols and 4% tannins (<xref ref-type="bibr" rid="B157">de Oliveira et al., 2024</xref>). <xref ref-type="table" rid="T1">Table 1</xref> shows the significant phenolic compounds present in different household food wastes.</p>
<table-wrap id="T1" position="float">
<label>TABLE 1</label>
<caption>
<p>Significant phenolic compounds extracted from common household food waste.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="center">Compound name</th>
<th align="center">Molecular formula</th>
<th align="center">Chemical structure</th>
<th align="center">Sources</th>
<th align="center">References</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="center">Cyanidin</td>
<td align="center">C<sub>6</sub>H<sub>11</sub>O<sub>6</sub>
<sup>&#x2b;</sup>
</td>
<td align="center">
<inline-graphic xlink:href="FRFST_frfst-2024-1388461_wc_tfx1.tif"/>
</td>
<td align="center">Cranberry pomace, apple peel, blueberry waste, grape seed, carrot waste, pomegranate, sweet cherries, and fig peel</td>
<td align="center">(<xref ref-type="bibr" rid="B188">Rocha et al., 2020</xref>; <xref ref-type="bibr" rid="B241">Vilas-Boas et al., 2020</xref>; <xref ref-type="bibr" rid="B69">Gon&#xe7;alves et al., 2021</xref>)</td>
</tr>
<tr>
<td align="center">Quercetin</td>
<td align="center">C<sub>15</sub>H<sub>10</sub>O<sub>7</sub>
</td>
<td align="center">
<inline-graphic xlink:href="FRFST_frfst-2024-1388461_wc_tfx2.tif"/>
</td>
<td align="center">Sugarcane, tomato waste, onion waste, apple pomace, papaya seed waste, grape skin, and peach waste</td>
<td align="center">(<xref ref-type="bibr" rid="B28">Bhat and Bhat, 2021</xref>; <xref ref-type="bibr" rid="B33">Caballero et al., 2021</xref>; <xref ref-type="bibr" rid="B81">Hunter et al., 2021</xref>; <xref ref-type="bibr" rid="B32">Bulkan et al., 2022</xref>)</td>
</tr>
<tr>
<td align="center">Catechin/epicatechin</td>
<td align="center">C<sub>15</sub>H<sub>14</sub>O<sub>6</sub>
</td>
<td align="center">
<inline-graphic xlink:href="FRFST_frfst-2024-1388461_wc_tfx3.tif"/>
</td>
<td align="center">Peanut skin, spent tea leaves, citrus peel, and grape skin</td>
<td align="center">(<xref ref-type="bibr" rid="B118">Liu et al., 2023</xref>; <xref ref-type="bibr" rid="B177">Putra et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Resveratrol</td>
<td align="center">C<sub>14</sub>H<sub>12</sub>O<sub>3</sub>
</td>
<td align="center">
<inline-graphic xlink:href="FRFST_frfst-2024-1388461_wc_tfx4.tif"/>
</td>
<td align="center">Grape marc, grape seeds, grape pomace, grape leaves, and peanut waste</td>
<td align="center">(<xref ref-type="bibr" rid="B33">Caballero et al., 2021</xref>; <xref ref-type="bibr" rid="B34">Caponio et al., 2023</xref>; <xref ref-type="bibr" rid="B195">Sahradyan, 2023</xref>)</td>
</tr>
<tr>
<td align="center">Hesperidin</td>
<td align="center">C<sub>28</sub>H<sub>34</sub>O<sub>15</sub>
</td>
<td align="center">
<inline-graphic xlink:href="FRFST_frfst-2024-1388461_wc_tfx5.tif"/>
</td>
<td align="center">Citrus Seed, citrus peel, and orange peel</td>
<td align="center">(<xref ref-type="bibr" rid="B166">Panzella et al., 2020</xref>; <xref ref-type="bibr" rid="B198">Samota et al., 2023</xref>
</td>
</tr>
<tr>
<td align="center">Proanthocyanidin</td>
<td align="center">C<sub>30</sub>H<sub>26</sub>O<sub>12</sub>
</td>
<td align="center">
<inline-graphic xlink:href="FRFST_frfst-2024-1388461_wc_tfx6.tif"/>
</td>
<td align="center">Grape berry, pomace, fruits, persimmon peel, gluten-free flours, nuts, red wine, grape seed, cocoa, and soybean husk</td>
<td align="center">(<xref ref-type="bibr" rid="B51">Direito et al., 2021</xref>; <xref ref-type="bibr" rid="B194">Sabra et al., 2021</xref>; <xref ref-type="bibr" rid="B231">Tasinov et al., 2021</xref>; <xref ref-type="bibr" rid="B251">Zhang et al., 2021</xref>; <xref ref-type="bibr" rid="B14">Arifah et al., 2022</xref>; <xref ref-type="bibr" rid="B78">Hoskin et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Ferulic acid</td>
<td align="center">C<sub>10</sub>H<sub>10</sub>O<sub>4</sub>
</td>
<td align="center">
<inline-graphic xlink:href="FRFST_frfst-2024-1388461_wc_tfx7.tif"/>
</td>
<td align="center">Rice bran, Citrus peel, maize bran, beetroot waste, rice husk, and sugar beet pulp</td>
<td align="center">(<xref ref-type="bibr" rid="B27">Bettio et al., 2020</xref>; <xref ref-type="bibr" rid="B82">Hussain et al., 2022</xref>; <xref ref-type="bibr" rid="B82">Hussain et al., 2022</xref>)</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="s5-2">
<title>5.2 Proteins</title>
<p>Proteins, which are essential macromolecules for various biological processes, are abundant in FW, including premium-quality proteins similar to those in meat, dairy, and eggs (<xref ref-type="bibr" rid="B101">Kishore, Pal, and Sarkar, 2024</xref>). Poultry and meat processing waste contain substantial muscle tissue, a rich protein source, while dairy processing waste may contain whey, a high-quality protein source (R. <xref ref-type="bibr" rid="B97">Khan et al., 2024</xref>). FW proteins can be classified into animal and plant-based sources, with plant-derived byproducts such as wheat bran and tofu residue being significant protein sources due to their nutritional value (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). The byproducts resulting from the preparation or processing of meat, fish, and dairy also encompass significant quantities of protein. For example, residual dairy materials may house whey protein, a premium and complete protein source, while waste from fish processing is a reservoir of valuable biomolecules, including enzymes, functional proteins, bioactive peptides, and oils rich in omega-3 fatty acids (<xref ref-type="bibr" rid="B61">Frias et al., 2020</xref>). Poultry byproducts&#x2014;lean meat, skins, heads, and feet&#x2014;present a sustainable source of animal protein. The safe extraction and utilization of protein from FW require the development of innovative processing technologies and the implementation of sound manufacturing practices to ensure the safety and quality of the derived protein (V. C. <xref ref-type="bibr" rid="B192">Roy VikashChandra et al., 2023</xref>).</p>
</sec>
<sec id="s5-3">
<title>5.3 Dietary fiber</title>
<p>Dietary fiber, the non-digestible segment of plant material, is pivotal in human health and is present in discarded FW from fruit, vegetables, and grain, as well as the byproducts of food processing. There are two categories of fiber: soluble, which readily dissolves in water and helps control blood sugar levels, and insoluble, which facilitates consistent bowel movements (<xref ref-type="bibr" rid="B167">Patil et al., 2024</xref>). FW contains considerable fiber, with amounts varying by food type and discarded portion. For instance, banana peel contains high levels of insoluble dietary fiber and is a source of xylo-oligosaccharides. Other sources of xylo-oligosaccharides include guava pomegranate pomace and orange pomace (<xref ref-type="bibr" rid="B41">Chatterjee and Mazumder, 2023</xref>). Jerusalem artichoke residues, typically discarded, can be used to extract high-purity soluble dietary fiber. Notwithstanding its substantial dietary fiber content, garlic peel is frequently discarded because of its limited soluble dietary fiber content (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). Nevertheless, adjusting the composition of dietary fiber derived from garlic peel has the potential to improve its solubility. Fructo-oligosaccharides, found in plants like banana peel, Jerusalem artichokes, garlic, and cassava waste, are excellent soluble dietary fiber sources (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>; M; <xref ref-type="bibr" rid="B130">Martins et al., 2023</xref>). Oat bran is a significant source of &#x3b2;-glucan and dietary fiber, while household FW, particularly orange peel, is a rich source of pectin. The oat bran segment serves as an abundant reservoir of &#x3b2;-glucan and dietary fiber, with no less than 5.5% weight of &#x3b2;-glucan and 16.0% dry-weight dietary fiber, with at least one-third being soluble (<xref ref-type="bibr" rid="B204">Selvamuthukumaran, 2024a</xref>). Domestic FW has attracted attention for its pectin content, and various types of FW are abundant in pectin. Judith and colleagues discovered that the pectin yield from orange peel was exceptionally high, reaching 247&#xa0;mg/g dry weight and positioning it as an optimal source of dietary fiber (<xref ref-type="bibr" rid="B140">Morais et al., 2020</xref>). The research also highlighted that apple waste is the second-largest pectin source, following citrus fruits (<xref ref-type="bibr" rid="B204">Selvamuthukumaran, 2024a</xref>).</p>
</sec>
<sec id="s5-4">
<title>5.4 Vitamins and minerals</title>
<p>Vitamins and minerals, essential micronutrients for human health, are abundant in FW from overproduction or spoilage. FW from fruits and vegetables is abundant in vitamins C and B-complex, and carotenoids, precursors of vitamin A, are found in discarded carrot and pumpkin bark and peel. Tomato waste, particularly skin, has high lycopene content, which is a carotenoid. Similarly, shrimp waste, a byproduct of this major international crustacean commodity, contains astaxanthin, a valuable carotenoid with antioxidant and anti-inflammatory properties, which is used in nutritional supplements, functional foods, cosmetics, and livestock feed (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). FW offers a potential solution to reduce waste and recover essential nutrients (<xref ref-type="bibr" rid="B228">Talan et al., 2021</xref>). The recovery of these nutrients could enable the fortification of food or the production of nutritional supplements which could improve nutrition and decrease dependence on conventional sources. The detection of essential minerals such as calcium, sodium, iron, magnesium, potassium, and zinc are encouraging, but more research is required to understand the nutritional value of vitamins in FW and develop effective extraction methods. (<xref ref-type="bibr" rid="B109">Kussmann, Cunha, and Berciano, 2023</xref>). Fruit, vegetables, grains, dairy products, and meat leftovers are common dietary sources of these minerals (<xref ref-type="bibr" rid="B184">Rao, Bast, and De Boer, 2021</xref>). For instance, fruit and vegetable peels have high calcium and potassium content, and dairy product waste is rich in calcium and phosphorus. Thus, FW offers the potential to recover essential nutrients and reduce waste, promoting a more fair and sustainable food system (<xref ref-type="bibr" rid="B51">Direito et al., 2021</xref>). <xref ref-type="table" rid="T2">Table 2</xref> signifies the bioactive compounds and value-added products that can be obtained from different domestic waste sources.</p>
<table-wrap id="T2" position="float">
<label>TABLE 2</label>
<caption>
<p>Bioactive compounds and value-added produces from household food waste sources.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="center">Food waste category</th>
<th align="center">Bioactive compounds and value-added produces</th>
<th align="center">References</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="center">Barley waste</td>
<td align="center">Phenolic compounds, phytates, &#x3b2;-glucan, insoluble dietary fiber, and vitamin E</td>
<td align="center">(<xref ref-type="bibr" rid="B187">Rico et al., 2020</xref>; <xref ref-type="bibr" rid="B215">Sharma et al., 2021</xref>; <xref ref-type="bibr" rid="B242">Walling et al., 2022</xref>; <xref ref-type="bibr" rid="B146">Nassef et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Rice bran and husk</td>
<td align="center">Tocopherols, bran oil, polyphenols, and &#x3b3;-oryzanol</td>
<td align="center">(<xref ref-type="bibr" rid="B117">Liu et al., 2021&#xa0;</xref>; <xref ref-type="bibr" rid="B118">Liu et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Wheat waste</td>
<td align="center">Fat-soluble vitamins, phenolic compounds, oligosaccharides, amino acids, lipid-soluble folic acid, anthocyanins, phytosterols, antioxidants, and peptides</td>
<td align="center">(<xref ref-type="bibr" rid="B212">Sharma et al., 2020&#xa0;</xref>; <xref ref-type="bibr" rid="B113">Liaqat et al., 2021&#xa0;</xref>; <xref ref-type="bibr" rid="B20">Balli et al., 2022&#xa0;</xref>; <xref ref-type="bibr" rid="B7">Akram, 2023</xref>)</td>
</tr>
<tr>
<td align="center">Legumes</td>
<td align="center">Fatty acids, proteins, phenolic materials, lipids, vitamins, activated carbon, and minerals</td>
<td align="center">(<xref ref-type="bibr" rid="B118">Liu et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Grape byproducts</td>
<td align="center">Flavanols, dietary fiber, grape seed oil, procyanidins, malates, tartaric acid, anthocyanins, tocopherol, pomace oil, single cell protein, oleanolic acid, polyphenols, and citric acid</td>
<td align="center">(<xref ref-type="bibr" rid="B129">Mart&#xed;nez-Meza et al., 2021</xref>; <xref ref-type="bibr" rid="B90">Carmona-Jim&#xe9;nez et al., 2022</xref>; <xref ref-type="bibr" rid="B158">Oliveira et al., 2022</xref>; <xref ref-type="bibr" rid="B230">Tapia-Quir&#xf3;s et al., 2022</xref>)</td>
</tr>
<tr>
<td align="center">Apple juice byproduct</td>
<td align="center">Fructo-oligosaccharides, aroma compounds, pectinases, procyanidins, citric acid, hydroxycinnamates, lactic acid, epicatechin, phloretin glycosides, butanol, anthocyanins, and anthocyanins</td>
<td align="center">(<xref ref-type="bibr" rid="B235">Toledo et al., 2019</xref>; <xref ref-type="bibr" rid="B121">Lyu et al., 2020</xref>; <xref ref-type="bibr" rid="B209">Shahidi et al., 2022</xref>)</td>
</tr>
<tr>
<td align="center">Citrus waste</td>
<td align="center">Organic acids, antioxidants, Hesperidin, phenols, pectin, ethanol, limonene essential oil, narirutin, naringin, and eriocitrin</td>
<td align="center">(<xref ref-type="bibr" rid="B137">Meneguzzo et al., 2020</xref>; <xref ref-type="bibr" rid="B193">Russo et al., 2021</xref>; <xref ref-type="bibr" rid="B38">Carullo et al., 2022</xref>; <xref ref-type="bibr" rid="B126">Maqbool et al., 2023</xref>; <xref ref-type="bibr" rid="B138">Miah et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Avocado byproducts</td>
<td align="center">Acerogenins, catechin, phytosterols, epicatechin, starch, chlorogenic acid, edible protein, homogentisic acid, gallic acid, cyanidin 3-glucoside, and phenolic compounds</td>
<td align="center">(<xref ref-type="bibr" rid="B63">Garc&#xed;a-Vargas et al., 2020</xref>; <xref ref-type="bibr" rid="B71">Gon&#xe7;alves et al., 2021</xref>; <xref ref-type="bibr" rid="B152">Novelina et al., 2022</xref>; <xref ref-type="bibr" rid="B128">Mart&#xed;nez-Guti&#xe9;rrez, 2023</xref>; <xref ref-type="bibr" rid="B168">Pazla et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Tomato waste</td>
<td align="center">Pectin, lycopene, and trans-lycopene</td>
<td align="center">(<xref ref-type="bibr" rid="B6">Ajlouni et al., 2020</xref>; <xref ref-type="bibr" rid="B72">G&#xf3;recka et al., 2020</xref>; <xref ref-type="bibr" rid="B144">Nagarajan et al., 2020</xref>; <xref ref-type="bibr" rid="B8">Alancay et al., 2023</xref>)</td>
</tr>
<tr>
<td align="center">Potato and sweet potato</td>
<td align="center">Biopolymer films, lysine, &#x3b2;-carotene, starch, &#x3b1;-tocopherol cellulolytic enzyme, adsorption dyes, gallic acid, caffeic acid, protein, and vanillic acid</td>
<td align="center">(<xref ref-type="bibr" rid="B100">Kim et al., 2019</xref>; <xref ref-type="bibr" rid="B236">Torres et al., 2020</xref>; <xref ref-type="bibr" rid="B172">Polivanova et al., 2021</xref>; <xref ref-type="bibr" rid="B136">Castro Mendoza et al., 2022</xref>; <xref ref-type="bibr" rid="B119">Lodu et al., 2022</xref>)</td>
</tr>
<tr>
<td align="center">Onions</td>
<td align="center">Quercetin, phenolic compounds, flavonoids, quercetin and glucosides, dietary fiber, and antioxidants</td>
<td align="center">(<xref ref-type="bibr" rid="B39">Celano et al., 2021</xref>; <xref ref-type="bibr" rid="B174">Prokopov et al., 2021</xref>; <xref ref-type="bibr" rid="B163">Paesa et al., 2022</xref>; <xref ref-type="bibr" rid="B164">Paesa et al., 2022</xref>; <xref ref-type="bibr" rid="B200">Santos and Martins, 2022</xref>)</td>
</tr>
<tr>
<td align="center">Milk</td>
<td align="center">Whey protein, ethanol, biodiesel, minerals, lactose, baker&#x2019;s yeast, and galacto-oligosaccharides</td>
<td align="center">(<xref ref-type="bibr" rid="B148">Nemati et al., 2020</xref>; <xref ref-type="bibr" rid="B16">Aslam et al., 2022</xref>; <xref ref-type="bibr" rid="B91">Johari et al., 2022</xref>)</td>
</tr>
<tr>
<td align="center">Cheese, casein, yogurt</td>
<td align="center">Lactose, animal feed, ethanol, whey protein, and single-cell proteins</td>
<td align="center">
<xref ref-type="bibr" rid="B40">&#xc7;elik and Temiz (2020)</xref>
</td>
</tr>
<tr>
<td align="center">Waste cooking oil</td>
<td align="center">Single-cell proteins, sterols, squalene, tocopherols, glycolipids, biodiesel, and biosurfactants</td>
<td align="center">(<xref ref-type="bibr" rid="B3">Adlin et al., 2020</xref>; <xref ref-type="bibr" rid="B153">Nugrahaningtyas et al., 2022</xref>)</td>
</tr>
<tr>
<td align="center">Olives</td>
<td align="center">Phytosterols, squalene, carotenoids, phenolic compounds, and dietary fiber</td>
<td align="center">(<xref ref-type="bibr" rid="B83">Hussain et al., 2020</xref>; <xref ref-type="bibr" rid="B253">Zulqarnain et al., 2021</xref>)</td>
</tr>
<tr>
<td align="center">Meat and poultry</td>
<td align="center">Probiotics, blood meal, lactic acid, meat and bone meal, feather meal, fertilizer, and animal feed</td>
<td align="center">(<xref ref-type="bibr" rid="B106">Kumar, 2021</xref>; <xref ref-type="bibr" rid="B227">Sypka et al., 2021</xref>; <xref ref-type="bibr" rid="B114">Liaqat et al., 2022</xref>)</td>
</tr>
<tr>
<td align="center">Crabs, lobster, and shrimps</td>
<td align="center">Protein, chitin, astaxanthin, calcium carbonate, and chitinase</td>
<td align="center">(<xref ref-type="bibr" rid="B76">Hardoko et al., 2017</xref>; <xref ref-type="bibr" rid="B62">Galasso et al., 2018</xref>; <xref ref-type="bibr" rid="B59">Feng et al., 2019</xref>; <xref ref-type="bibr" rid="B139">Miron et al., 2022</xref>)</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
</sec>
<sec id="s6">
<title>6 Traditional and novel techniques for the isolation of bioactive compounds</title>
<p>The choice of extraction method for removing chemicals from fruit and vegetable waste (FVW) is crucial, as it determines the outcome: it influences the diversity and number of bioactive compounds that can be obtained. In other words, the optimal utilization of FVW depends on the optimal extraction method (<xref ref-type="bibr" rid="B56">F&#x103;rca&#x15f; et al., 2019</xref>). The choice of solvent, which mainly depends on the polarity of the target compound, affects the effectiveness of traditional extraction techniques (<xref ref-type="bibr" rid="B44">Chojnacka and Moustakas, 2024</xref>). Other factors to consider are molecular compatibility, mass transfer efficiency, co-solvent use, environmental impact, human toxicity, and economic feasibility. To optimize the extraction of bioactive compounds, common methods such as Soxhlet extraction, hydro-distillation, and maceration need to account for these parameters (<xref ref-type="bibr" rid="B36">Carrasco-Sandoval et al., 2021</xref>; R; <xref ref-type="bibr" rid="B130">Martins et al., 2023a</xref>).</p>
<p>Soxhlet extraction, a method for isolating lipids, was developed in 1879 by the German chemist Franz Ritter von Soxhlet (R. <xref ref-type="bibr" rid="B131">Martins et al., 2023b</xref>). It is widely used method for extracting valuable compounds from natural sources, serving as a standard for evaluating newer extraction techniques (<xref ref-type="bibr" rid="B154">Nural&#x131;n, 2024</xref>). The procedure is as follows. A thimble with a small amount of dried material is placed in a distillation flask filled with a chosen solvent. The solvent evaporates and condenses, dissolving the desired components from the solid plant material in the thimble (<xref ref-type="bibr" rid="B85">Ibrahim et al., 2024</xref>). The target compounds accumulate in the main flask liquid, which automatically returns to the flask when it reaches a certain level. The solvent is then continuously recycled to the thimble, and this cycle is repeated until the extraction is complete (<xref ref-type="bibr" rid="B88">Jagannath and Biradar, 2019</xref>).</p>
<p>Maceration is a widely used low-cost technique for extracting bioactive compounds and essential oils from plants (<xref ref-type="bibr" rid="B183">Ranjha et al., 2020</xref>). It is a technique that enhances the extraction of bioactive compounds and essential oils from plant materials by accelerating the diffusion and dilution of concentrated liquids. Maceration involves three steps: grinding the plant material, dissolving it in a solvent in a vessel, and filtering and pressing the liquid. Hydro distillation is an older method that does not require organic solvents and can be applied to fresh plant material (<xref ref-type="bibr" rid="B85">Ibrahim et al., 2024</xref>). It consists of placing the plant material in a specific still chamber, adding water, and boiling the mixture (<xref ref-type="bibr" rid="B77">Hikal et al., 2021</xref>). By applying steam to the plant material instead of immersing it, this method extracts the desired bioactive molecules that require steam and hot water to be released. However, hydro distillation may also result in the loss of some volatile chemicals that are sensitive to high temperatures (<xref ref-type="bibr" rid="B150">Nguyen et al., 2023</xref>). Conventional extraction suffers from several disadvantages, such as prolonged extraction time, expensive and high-quality solvents, considerable solvent loss, limited extraction selectivity, and thermal degradation of heat-sensitive compounds (T. <xref ref-type="bibr" rid="B245">Wang et al., 2024</xref>).</p>
<p>Non-conventional extraction methods are innovative and alternative approaches that overcome the inherent limitations of conventional methods (<xref ref-type="bibr" rid="B160">Osorio-Tob&#xf3;n, 2020</xref>). These advanced techniques, developed in the last five&#xa0;decades, offer promising prospects for efficient and selective extraction. Some of the most notable and applicable of these techniques are enzyme-assisted extraction, microwave-assisted extraction, ultrasound-assisted extraction, and pulsed electric field extraction (M. <xref ref-type="bibr" rid="B211">Sharma et al., 2024</xref>).</p>
<sec id="s6-1">
<title>6.1 Super-critical fluid extraction</title>
<p>Supercritical fluid extraction (SFE) is an environmentally friendly method for extracting bioactive compounds from natural sources. SFE uses supercritical carbon dioxide (SC-CO<sub>2</sub>) or other fluids that are economical and efficient. By carefully regulating the temperature and pressure of the fluids, this technique allows for selective extraction using various fluids. SFE is an effective solvent extraction technique that offers advantages over traditional solvent extraction methods, such as increased efficiency and environmental friendliness for the successful extraction of polyphenols, flavonoids, oils, and phenolics from a variety of plant materials. (<xref ref-type="bibr" rid="B159">Ortiz-Sanchez et al., 2024</xref>). Employing supercritical fluid extraction to recover bioactive components from orange peel waste (OPW), extracted hesperidin&#x2014;a flavonoid with anti-inflammatory and antioxidant qualities&#x2014;in significant quantities (8.18&#xa0;g/kg OPW db.). SFE has the potential to improve the bioactive chemical output and quality of food waste (<xref ref-type="fig" rid="F2">Figure 2</xref>).</p>
<fig id="F2" position="float">
<label>FIGURE 2</label>
<caption>
<p>Bioactive compounds extracted from orange-peel waste through super-critical fluid extraction (SFE).</p>
</caption>
<graphic xlink:href="frfst-04-1388461-g002.tif"/>
</fig>
</sec>
<sec id="s6-2">
<title>6.2 Sub-critical water extraction</title>
<p>The process of extracting phenolic compounds by subcritical water extraction (SWE) has become increasingly popular. When water is heated to between 100&#xa0;&#xb0;C and 374&#xa0;&#xb0;C under pressure and keeps its liquid condition below the critical pressure of 22&#xa0;MPa, it is referred to as subcritical water. <xref ref-type="bibr" rid="B65">Gbashi et al. (2017)</xref> investigated the effectiveness of SWE in extracting polyphenolic compounds from <italic>Terminalia chebula Retz</italic>. fruit. The study revealed that the amount of gallic and ellagic acid extracted increased with subcritical water temperature up to 180&#xb0;C, while the highest amount of corilagin was obtained at 120&#xb0;C. The experiment involved subjecting the samples to temperatures of 100&#xa0;&#xb0;C&#x2013;220&#xb0;C for 20&#xa0;min; at 160&#xb0;C, the reaction times ranged from 10 to 50&#xa0;min (<xref ref-type="bibr" rid="B52">Kim et al., 2017</xref>), Enhancing subcritical water hydrolysis in pumpkin leaves produces certain phenolic chemicals. The hydrolyzate of pumpkin leaves include the primary phenolic compounds gentisic, ferulic, p-coumaric, and caffeic acids (<xref ref-type="fig" rid="F3">Figure 3</xref>). <xref ref-type="bibr" rid="B134">Mayanga-Torres et al. (2017)</xref> extracted total phenolic components from two typical coffee waste leftovers (powder and defatted cake) using subcritical water and semi-continuous flow conditions. The largest amount of total phenolic compounds (26.64&#xa0;mg GAE/g of coffee powder) was recovered at 200&#xb0;C and 22.5&#xa0;MPa.</p>
<fig id="F3" position="float">
<label>FIGURE 3</label>
<caption>
<p>Extraction of biologically active compounds from plant waste employing subcritical water extraction.</p>
</caption>
<graphic xlink:href="frfst-04-1388461-g003.tif"/>
</fig>
</sec>
<sec id="s6-3">
<title>6.3 Enzyme assisted extraction</title>
<p>Enzyme-assisted extraction (EAE) uses water as a solvent rather than organic solvents, so it is thought to be a more environmentally benign method of extracting oil and bioactive chemicals. The extraction efficiency of lycopene from the peel portion of tomato processing waste is greatly increased by using enzyme mixes with cellulolytic and pectinolytic activity. Moreover, this technology has become economically viable for mass production thanks to the affordable prices of food-grade enzyme products on the market (<xref ref-type="bibr" rid="B175">Prokopov et al., 2017</xref>; <xref ref-type="bibr" rid="B45">Costa et al., 2020</xref>). The study examined the effectiveness of the enzyme-assisted extraction of sativoside, a plant-derived bioactive compound, for its use in the food and nutraceutical sectors. It found that enzyme preparations, either singly or in mixtures, could increase the extraction of bioactive compounds from plant cells by breaking down the cell walls and facilitating extraction. Enzyme-assisted extraction, which uses mild processing conditions and enzymes that can catalyze reactions in water, could be an alternative to conventional solvent-based extraction methods. <xref ref-type="fig" rid="F4">Figure 4</xref> demonstrates the working procedure of EAE to extract bioactive compounds.</p>
<fig id="F4" position="float">
<label>FIGURE 4</label>
<caption>
<p>Extraction of bioactive compounds from plant sources waste through enzyme-assisted extraction.</p>
</caption>
<graphic xlink:href="frfst-04-1388461-g004.tif"/>
</fig>
<p>
<xref ref-type="bibr" rid="B45">Costa et al. (2020)</xref> examined the efficacy of EAE for extracting sativoside, a plant-derived bioactive compound, for application in the food and nutraceutical sectors. They found that enzyme preparations, either alone or in combination, could enhance the extraction of bioactive compounds from plant cells by facilitating cell disruption and extraction. EAE, which uses enzymes to catalyze reactions in water and mild processing conditions, could be an alternative to conventional solvent-based extraction methods.</p>
</sec>
<sec id="s6-4">
<title>6.4 Ultrasound assisted extraction</title>
<p>Ultrasound-assisted extraction (UAE) is a simple and effective method for extracting bioactive compounds from plants. The extraction yield depends on the plant type and ultrasonic frequency used (<xref ref-type="bibr" rid="B90">Jim&#xe9;nez-Moreno et al., 2020</xref>; <xref ref-type="bibr" rid="B103">Koraqi et al., 2023</xref>). High-performance liquid chromatography enables the identification of the extracted chemicals. Water-soluble polysaccharides from <italic>Agaricus bisporus</italic> by-products were extracted by UAE by <xref ref-type="bibr" rid="B95">Kaleem et al. (2019)</xref> and <xref ref-type="bibr" rid="B4">Aguil&#xf3;-Aguayo et al. (2017)</xref>. They reported the presence of &#x3b2;-Glucan with different particle sizes of 1.01 and 0.98&#xa0;g/100&#xa0;g dry bulk, respectively. The optimal extraction conditions were 15&#xa0;min of extraction time, 100&#xa0;m of amplitude, and 80% ethanol for precipitation, resulting in an extraction yield of 4.7%. <xref ref-type="bibr" rid="B102">Koraqi et al. (2023)</xref> and <xref ref-type="bibr" rid="B226">Sun et al. (2024)</xref> investigated the UAE of polyphenols from <italic>Pleurotus citrinopileatus</italic> mushroom with water and ethanol as solvents. They found that the optimal extraction parameters for water and ethanol were 44&#xb0;C, 14&#xa0;min, and 20&#xa0;mL/g and 39&#xb0;C, 13&#xa0;min, and 20&#xa0;mL/g, respectively. <xref ref-type="bibr" rid="B104">Koraqi et al., 2024</xref> also demonstrated that UAE enhanced the yield and antioxidant activity of polyphenols over conventional methods (<xref ref-type="fig" rid="F5">Figure 5</xref>).</p>
<fig id="F5" position="float">
<label>FIGURE 5</label>
<caption>
<p>Extraction of bioactive compounds from peel, <italic>Agaricus bisporus</italic>, and <italic>Ieutrotus</italic> mushroom through ultrasound-assisted extraction.</p>
</caption>
<graphic xlink:href="frfst-04-1388461-g005.tif"/>
</fig>
</sec>
<sec id="s6-5">
<title>6.5 Microwave-assisted extraction</title>
<p>Microwave-assisted extraction (MAE) is an innovative extraction technique that utilizes both solvent and microwave irradiation to extract plant metabolites. The main advantage of MAE over conventional methods such as Soxhlet and UAE is its high speed of extraction (<xref ref-type="bibr" rid="B216">Shen et al., 2023</xref>). Several studies have investigated the optimal conditions for MAE of different plant extracts. For example, <xref ref-type="bibr" rid="B223">Sonar and Rathod (2020)</xref> used water as a solvent to extract mangiferin from <italic>Mangifera indica</italic> leaves and found that the best parameters were 5&#xa0;min of extraction time, 1:20 solid-to- ratio, and 272&#xa0;W of microwave power, yielding 55&#xa0;mg/g of mangiferin. Likewise, Filip et al. (2017) applied a response surface method to optimize the MAE of polyphenols from basil (<italic>Ocimum basilicum L.</italic>), obtaining 0.849&#xa0;g of catechin equivalents/100&#xa0;g of total flavonoids and 4.299&#xa0;g of GAE/100&#xa0;g of total polyphenols using 50% ethanol, 442&#xa0;W of microwave power, and 15&#xa0;min of extraction time (<xref ref-type="bibr" rid="B181">Ranasinghe et al., 2024</xref>). MAE of bioactive components from defatted date seeds has been an improvement.</p>
<p>MAE is a recommended method for extracting bioactive compounds from plant materials due to advantages such as high extraction efficiency, short extraction time, low solvent consumption, and high extraction selectivity (<xref ref-type="fig" rid="F6">Figure 6</xref>). The optimal conditions for MAE were determined to be 600&#xa0;W of power, 5&#xa0;min of extraction time, 50% of ethanol concentration, and 30&#xa0;mL/g solvent-to-solid ratio. These conditions achieved the highest yields of total phenolic content (TPC) (13.86&#xa0;mg GAE/g), total flavonoid content (TFC) (4.32&#xa0;mg QE/g), and antioxidant activity (DPPH) (62.31%) (<xref ref-type="bibr" rid="B24">Begi&#x107; et al., 2020</xref>).</p>
<fig id="F6" position="float">
<label>FIGURE 6</label>
<caption>
<p>Extraction of bioactive compounds from <italic>Mangifera indica</italic> and basil leaf through microwave-assisted extraction.</p>
</caption>
<graphic xlink:href="frfst-04-1388461-g006.tif"/>
</fig>
</sec>
<sec id="s6-6">
<title>6.6 Deep eutectic solvents</title>
<p>Deep eutectic solvents (DESs) are a new type of environmentally friendly and biodegradable solvent that have been recently applied to the extraction of phenolic compounds (<xref ref-type="bibr" rid="B2">Zainal-Abidin et al., 2017</xref>). These are formed by heating and mixing hydrogen bond donors (HBDs) and acceptors (HBAs) to a specific temperature (<xref ref-type="bibr" rid="B1">Abbasi, Farooq, and Anderson, 2021</xref>). DESs have the ability to dissolve phenolic compounds and exhibit lower melting points than their individual components (<xref ref-type="bibr" rid="B247">Wong et al., 2024</xref>). Choline chloride (ChCl) is a widely used and affordable salt for the preparation of DESs due to its non-toxicity (<xref ref-type="bibr" rid="B55">Elhamarnah et al., 2024</xref>). Urea, ethylene glycol, and glycerol are common hydrogen bond donors (HBDs) in DESs, along with alcohols, amino acids, carboxylic acids, and sugars. DESs are typically low-cost, easy to synthesize, and biodegradable (<xref ref-type="bibr" rid="B115">Lim et al., 2024</xref>). Density, viscosity, and conductivity are some of the unique properties of DESs that depend on their composition (Zhang et al., 2024). These properties can be modified using different HBAs and HBDs. DESs are usually less conductive, more viscous, and denser than water (<xref ref-type="bibr" rid="B142">Mu et al., 2023</xref>).</p>
</sec>
</sec>
<sec id="s7">
<title>7 Utilization of bioactive compounds for food application</title>
<sec id="s7-1">
<title>7.1 Nutraceuticals</title>
<p>Nutraceuticals are compounds extracted or purified from food sources that have pharmacological effects and confer health benefits beyond basic nutrition. These compounds, such as anti-inflammatory agents, cardio-protectives, and antioxidants, play a vital role in disease prevention and health promotion (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). Plant-based food waste is a sustainable source of bioactive components that can replace synthetic chemicals in various applications. These components, found in different plant residues, have potential benefits for human and environmental health (<xref ref-type="bibr" rid="B169">Petrovic and Barbinta-Patrascu, 2023</xref>). Resveratrol-rich grape skins, a by-product of winemaking, exhibit antioxidant activity and anti-inflammatory effects that contribute to liver detoxification and cellular protection (<xref ref-type="bibr" rid="B43">Chedea et al., 2021a</xref>). Mango peel, a rich source of phenolic compounds and vitamins, has demonstrated potential benefits in lowering the risk factors of diseases such as cancer, cataracts, Alzheimer&#x2019;s, and Parkinson&#x2019;s (<xref ref-type="bibr" rid="B43">Chedea et al., 2021a</xref>). Additionally, caffeine extraction from waste tea leaves is a promising technique for recycling tea by-products (<xref ref-type="bibr" rid="B48">Debnath, Haldar, and Purkait, 2021</xref>). Recent studies have indicated that food waste can be a valuable source of diverse bioactive compounds that can confer health benefits to humans and animals. Algae and food waste contain various bioactive substances with potential health effects. Algal polysaccharides exhibit immunomodulatory and anti-allergic activities, while food waste monosaccharides possess antithrombotic, antiviral, and antioxidant properties (S. <xref ref-type="bibr" rid="B67">Ghosh et al., 2022</xref>). Moreover, xylo-oligosaccharides (XOS) derived from fruit pomace have prebiotic properties that stimulate the proliferation of beneficial gut microbiota (<xref ref-type="bibr" rid="B127">Marim and Gabardo, 2021</xref>). Galacto-oligosaccharides (GOS) and other bioactive compounds derived from dairy byproducts and potato peel also have prebiotic properties and antiparasitic activities (<xref ref-type="bibr" rid="B25">Ben-Othman, J&#xf5;udu, and Bhat, 2020</xref>; <xref ref-type="bibr" rid="B70">Gon&#xe7;alves et al., 2023</xref>). Furthermore, fructo-oligosaccharides (FOS) obtained from different plant byproducts have demonstrated health benefits, such as better glycemic regulation, immune enhancement, antioxidant activity, and carcinogen suppression (<xref ref-type="bibr" rid="B178">Rahim et al., 2021</xref>). Banana extracts enriched with bioactive compounds exhibit anti-leishmanial activity and have potential applications in the therapy of protozoan infections (<xref ref-type="bibr" rid="B214">Poonam Sharma et al., 2021a</xref>; <xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). The use of these various bioactive compounds from food waste supports sustainability, enhances health, and reduces environmental damage (<xref ref-type="bibr" rid="B186">Ribeiro et al., 2022</xref>; <xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>).</p>
</sec>
<sec id="s7-2">
<title>7.2 Food additives</title>
<p>Additives used in food are chemicals that are used to improve the taste, texture, or other sensory aspects of food. Overripe berries, undesirable fruits, peels that are thrown away, pomace, and seeds are examples of byproducts that provide untapped potential for creative antioxidant food additions (<xref ref-type="bibr" rid="B151">Nirmal et al., 2023</xref>). Recent research has proven the usefulness of discarded olive oil extract rich in polyphenols as an antioxidant in lamb patties, inhibiting both protein and lipid oxidation, retaining color, and extending shelf life by up to as 3&#xa0;days. (<xref ref-type="bibr" rid="B205">Serra, Salvatori, and Pastorelli, 2021</xref>). Apple peel extract is effective in preventing peroxides and thiobarbituric acid-reactive compounds from oxidizing chilled minced rainbow fish (<xref ref-type="bibr" rid="B232">Taskaya, Ozturk-Kerimoglu, and Serdaroglu, 2024</xref>). Apple byproducts and strawberry tree extracts suppress polyphenol oxidase and peroxidase to reduce enzymatic browning, a frequent problem in fresh food, and improve consumer acceptability (V. F. R. <xref ref-type="bibr" rid="B132">Martins et al., 2024</xref>).</p>
<p>Bioactive substances found in food waste, such as terpenoids, peptides, polysaccharides, and phenolic compounds, function as organic antibacterial agents for food preservation. Shrimp and organic leafy greens have less bacterial contamination when treated with olive leaf extract (<xref ref-type="bibr" rid="B31">Bodie et al., 2024</xref>). Meat products that include bioactive compounds have been shown to have improved quality and longer shelf life (<xref ref-type="bibr" rid="B87">Ivane et al., 2024</xref>). These compounds have also been demonstrated to have antibacterial activity against microbes that cause fish spoilage. The antibacterial activity of pomegranate peel extract against <italic>S. aureus</italic> and <italic>B. cereus</italic> shows promise when applied to chicken products (<xref ref-type="bibr" rid="B240">Viacava, Marcovich, and Ansorena, 2024</xref>).</p>
<p>Although commercial colorants are primarily synthetic, natural sources such as carotenoids and anthocyanins are also present. Anthocyanins are present in berries, particularly blackberry remnants, purple sweet potatoes, crimson kale, and black carrots, and distillery byproducts provide important natural colorants and nutraceuticals (A. <xref ref-type="bibr" rid="B66">Ghosh et al., 2024</xref>). Carotenoids may be found in citrus peel and pomace which can act as natural colorants and prolong the shelf life of food and beverages by protecting them against pollutants, infections, and unwanted tastes (<xref ref-type="bibr" rid="B196">Saini et al., 2022</xref>).</p>
<p>Pectin is an example of a water-insoluble fiber that functions as a food that is good for the health of the gut microbiota (<xref ref-type="bibr" rid="B19">Baky et al., 2022</xref>). Citrus peel, which is abundant in pectin, is a great way of extracting it and using it as a gelling agent in meat, baked goods, and confections. Unlike sorghum protein, avocado byproducts, which are 30% waste product, provide edible protein with better potential to absorb water and oil and to scavenge free radicals. Avocado seed-derived starch exhibits favorable properties that make it a promising ingredient for biodegradable food packaging materials or as a thickening or gelling agent or medicinal carrier [179, 180]. These creative methods show how food waste (FW) may be turned into useful resources to improve the sustainability and quality of food (<xref ref-type="bibr" rid="B234">Teshome et al., 2023</xref>).</p>
</sec>
<sec id="s7-3">
<title>7.3 Biosurfactants</title>
<p>The utilization of biosurfactants, which are derived from microorganisms, has had a significant upsurge in the global market, amounting US$30.64 billion in value, thus highlighting their importance in various industries (<xref ref-type="bibr" rid="B17">Aslam et al., 2024</xref>; P; <xref ref-type="bibr" rid="B218">Singh, Patil, and Rale, 2019</xref>). Despite their traditional higher costs than synthetic counterparts, it has been demonstrated that the use of FW as a substrate for biosurfactant manufacture is sustainable and cost-effective. FW, due to its abundance and richness in nutrients, particularly excels in rhamnolipid and sophorolipid biosurfactant production. Life cycle assessments have confirmed the environmental benefits of biosurfactants, with waste whey, used kitchen oil, and soy molasses being considered promising FW sources. Future endeavors in this direction involve optimizing FW treatment, biosurfactant purification, and the overall production life cycle to enhance environmental applications and emphasize cost reduction (<xref ref-type="bibr" rid="B93">Jumbo et al., 2022</xref>; <xref ref-type="bibr" rid="B225">Sulaiman, 2024</xref>).</p>
</sec>
<sec id="s7-4">
<title>7.4 Single-cell proteins</title>
<p>Single-cell proteins (SCPs) are a broad class of proteins derived from live or dried cell biomass in microbial cultures. They can be refined, edible, or in their raw form. SCPs are a multipurpose ingredient that may be used in the place of meals high in protein for both human and animal consumption. It has a significant potential for converting organic resources and stands out from other protein sources. With an amino acid content higher than that of soybeans and fast microbial growth, SCP is resistant to environmental stressors (<xref ref-type="bibr" rid="B243">Wang et al., 2020</xref>; <xref ref-type="bibr" rid="B84">Ib&#xe1;&#xf1;ez, Garrido-Chamorro and Barreiro, 2023</xref>).</p>
<p>FW is a prime example of a fermentation substrate for the synthesis of SCP. Using a two-stage fermentation method, <italic>Yarrowia lipolytica</italic> has a high protein concentration (38.8% &#xb1; 0.2% w/w biomass dry weight), highlighting the effectiveness of FW in SCP conversion [192]. The volatile fatty acids of FW fermentation broth are highlighted by photosynthetic bacteria as a potential substitute since they depend on the bioavailability of carbon sources. With a noteworthy carbon source conversion capacity of 0.99&#xa0;mg-biomass/mg-chemical oxygen requirement, strategic carbon source control improves SCP production (2088.4&#xa0;mg/L) (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>; <xref ref-type="bibr" rid="B21">Bangar et al., 2023</xref>).</p>
<p>Wastewater from coffee production, which is high in proteins, sugars, and salts, is an important substrate for SCP bioconversion. To produce SCPs with a protein concentration of 37.4%&#x2013;39%, yeast effectively assimilates glucose, mannose, and fructose. This makes yeast an affordable source of protein for animal feed additives (<xref ref-type="bibr" rid="B197">Salazar-L&#xf3;pez et al., 2022</xref>). The potential utilization of byproducts to create SCPs for supplemental usage in a variety of culinary goods is demonstrated by the seamless integration of SCPs from fermented vegetable remnants into wheat flour bread without comprising sensory characteristics (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>).</p>
</sec>
<sec id="s7-5">
<title>7.5 Organic fertilizers</title>
<p>FW is composted and vermicomposted to create organic fertilizers, which are considered an environmentally beneficial substitute for their chemical equivalents and also function as sources of animal nourishment (<xref ref-type="bibr" rid="B54">Dutta and Kumar 2021</xref>). Growing mushrooms with FW reduces environmental impacts while enhancing crop yield and altering the bacterial populations in the soil (<xref ref-type="bibr" rid="B79">Huang et al., 2023</xref>). As a byproduct of anaerobic digestion, biogas waste from FW is rich in nutrients and trace elements that promote plant development, making it a great organic fertilizer or soil conditioner (<xref ref-type="bibr" rid="B213">Pooja Sharma et al., 2023</xref>). FW and organic waste are mixed in digesters during anaerobic digestion, with microbes turning them into nutrient-rich anaerobic digestate. This substance can initially harm plants, but eventually makes the soil better for growing them; it can help ryegrass grow more than regular fertilizers by 5%&#x2013;30% (<xref ref-type="bibr" rid="B22">Battista et al., 2022</xref>). While FW compost helps with the chelator-enhanced phytoremediation of metal-contaminated soils, the anaerobic fermentation of kitchen waste creates volatile fatty acids with soil-cleaning capabilities for vanadium and chromium-contaminated soils (<xref ref-type="bibr" rid="B145">Nasir et al., 2023</xref>; <xref ref-type="bibr" rid="B149">Ng, 2023</xref>).</p>
<p>Organic fertilizers are produced using a variety of techniques, such as chemical hydrolysis and anaerobic digestion, and they may be found in a range of forms, such as soil conditioners, composts, and organic fertilizers (<xref ref-type="bibr" rid="B171">Pigoli et al., 2021</xref>). Liquid organic fertilizers improve overall performance by providing targeted application, quick plant absorption, reduced volume needs, and streamlined breakdown processes (<xref ref-type="bibr" rid="B238">Vejan et al., 2021</xref>). As demonstrated by the culture of <italic>Chlorella</italic> for the manufacture of biodiesel, the incorporation of methane-oxidizing bacteria increases the potency of organic fertilizer and promotes microalgae development (<xref ref-type="bibr" rid="B111">Helen La, 2022</xref>).</p>
</sec>
<sec id="s7-6">
<title>7.6 Bioplastics</title>
<p>Bioplastics are a form of plastic material derived from sustainable sources such as starch, plant oils, and microorganisms. They are considered an eco-friendly alternative to traditional plastics as they have a significantly lower impact on the environment. Although the global production of bioplastics was only 1% in 2019&#x2014;equivalent to 3.8 million tons&#x2014;it is expected to grow in the future (<xref ref-type="bibr" rid="B57">Farghali et al., 2023</xref>). The transition from oil-based synthetic plastics to bioplastics not only fits with sustainability objectives but also helps alleviate worries about global warming because bioplastics take less energy to produce (57&#xa0;MJ/kg) than synthetic plastics (77&#xa0;MJ/kg) (<xref ref-type="bibr" rid="B203">Schirmeister and M&#xfc;lhaupt, 2022</xref>).</p>
<p>FW may be bio-converted into bioplastics, which is an efficient waste management technique. For successful deployment, pretreatment techniques that improve the biological and physicochemical characteristics of FW are necessary (<xref ref-type="bibr" rid="B224">Sreekala, Ismail, and Nathan, 2022</xref>). Commonly employed hydrolysis methods include enzymatic, chemical, bio, and physical. After being refined with sugarcane molasses, <italic>Alcaligenes</italic> sp. NCIM 5085 produced an astounding 70.89% of high molecular weight polyhydroxybutyrate (PHB) (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>). A different strain, <italic>Halomonas campaniensis LS21</italic>, was grown in FW and produced 70% PHB by using the cellulose, proteins, starch, and fatty acids found in the waste. Significant commercial potential exists for biopolymers such as polyhydroxyalkanoates (PHA), polybutylene succinate (PBS), polylactic acid (PLA), and polyvinyl alcohol (PVA). Nevertheless, there are still issues with the commercialization of bio-composites, such as elevated processing expenses, shortage of raw input, and lackluster cost competitiveness, which call for deliberate progress (<xref ref-type="bibr" rid="B143">Mujtaba et al., 2022</xref>).</p>
</sec>
<sec id="s7-7">
<title>7.7 Animal feed</title>
<p>FW is a particularly interesting substitute source material for making animal feed (<xref ref-type="bibr" rid="B53">Dou et al., 2024</xref>). Plant leftovers, which are usually more than 80% wet, require an extra drying stage. The periodic variations in the waste&#x2019;s composition necessitate feed makers making regular adjustments to their compositions. Dried fish meal contains mostly carbohydrates (65%), followed by crude fiber (13%), ash (8%), ether extract (2%), and crude protein (12%) (<xref ref-type="bibr" rid="B53">Dou et al., 2024</xref>). Pigs primarily obtain their energy from carbohydrates; however, high-fiber concentrations can impair digestion and energy availability (<xref ref-type="bibr" rid="B94">Valente Junior et al., 2024</xref>). Vegetable waste may be used in diets, but it is necessary to supplement it with hay from <italic>Cenchrus ciliaris</italic>, a mineral combination, and regular salt (<xref ref-type="bibr" rid="B124">Maeresera, 2020</xref>). FW may be transformed into safe, high-quality animal feed products with increased value thanks to modern processing technology (<xref ref-type="bibr" rid="B189">Rohini et al., 2020</xref>). Compared to heating and ensiling, extrusion, pelletizing, and dehydration result in extended shelf life. Although there is a balanced nutritional content in livestock feed made from fermented, heat-treated FW, problems arise when it comes to sheep and cattle leftovers in raw FW. These drawbacks are mitigated, particularly for ruminants, by administering FW-derived feed. Protein-rich FW has become an important resource for making fish feed pellets, reducing the quantity of waste disposed in landfills. When supplemented with yeast, bromelain, and papain, FW derived from plants can increase grass carp growth by up to 63.6% while also improving immunity (<xref ref-type="bibr" rid="B118">Liu et al., 2023a</xref>; <xref ref-type="bibr" rid="B147">Nath et al., 2023</xref>) (<xref ref-type="fig" rid="F7">Figure 7</xref>).</p>
<fig id="F7" position="float">
<label>FIGURE 7</label>
<caption>
<p>Applications of bioactive compounds in food.</p>
</caption>
<graphic xlink:href="frfst-04-1388461-g007.tif"/>
</fig>
</sec>
</sec>
<sec id="s8">
<title>8 Challenges and future perspectives</title>
<p>While several food waste (FW) conversion technologies have been established at the laboratory scale, there are still obstacles and constraints to overcome before these technologies can be sustainably implemented at the commercial level (<xref ref-type="bibr" rid="B202">Sarker et al., 2024a</xref>; <xref ref-type="bibr" rid="B74">Grossi, Lange, and Amaral, 2024</xref>). Future research must address these concerns. The majority of the technologies discussed above are still in the research and development stage, and a major barrier is the high extraction costs due to expensive equipment, solvents, and energy. For the successful industrial implementation of FW conversion, some of the challenges to be addressed include the low efficiency of the extraction processes, the poor stability of natural bioactive compounds compared to their synthetic analogs, and difficulties in managing the residual streams that may have adverse impacts on the environment or human health if not properly treated or utilized. Therefore, it is not yet possible to conclude that FW-related problems may be successfully resolved by using these technologies alone (S. <xref ref-type="bibr" rid="B11">AlQahtani et al., 2024</xref>; <xref ref-type="bibr" rid="B202">Sarker et al., 2024a</xref>).</p>
<sec id="s8-1">
<title>8.1 Sustainability concerns in FW conversion</title>
<p>Future difficulties will mostly consist of increasing extraction operation efficiency and creating new, ecologically friendly techniques (<xref ref-type="bibr" rid="B202">Sarker et al., 2024a</xref>; <xref ref-type="bibr" rid="B73">Goria et al., 2024</xref>). Further investigation will also be necessary to ascertain the safety and bioavailability of the extracted components as well as to find new uses for these products. The ultimate objective is to recycle and revitalize waste motivated by the pressing issue of worldwide FW production (<xref ref-type="bibr" rid="B9">Ali et al., 2024</xref>; <xref ref-type="bibr" rid="B47">D&#x2019;Alessandro et al., 2024</xref>). Researchers must weigh the advantages of the extra goods acquired against the price of large-scale FW conversion (S. <xref ref-type="bibr" rid="B191">Roy and Roy, 2024</xref>).</p>
</sec>
<sec id="s8-2">
<title>8.2 Future research priorities for FW conversion</title>
<p>The development of targeted extraction techniques for various FW sources or bioactive components of interest will be essential in the coming years. Utilizing green solvents as much as is feasible is crucial to reducing effects on the environment and public health (A. <xref ref-type="bibr" rid="B210">Sharma and Lee, 2024</xref>). Setting particular requirements for value-added goods arising from FW conversion may be challenging yet valuable, given the absence of a unified norm for FW sources. Additionally, an attempt should be made to close the quality difference between the original product and value-added goods produced by FW. Replacing present products with value-added commodities created from FW is one possible area of research (<xref ref-type="bibr" rid="B23">Bechir et al., 2024</xref>). Further life cycle assessment studies on produce that are derived from FW are needed. In addition to exploiting waste and uncovering value, future studies on FW should focus on employing FW as an economical and high-grade source of value-added products (V. <xref ref-type="bibr" rid="B107">Kumar and Verma, 2024</xref>).</p>
</sec>
</sec>
<sec sec-type="conclusion" id="s9">
<title>9 Conclusion</title>
<p>In conclusion, bioactive compound inherent in the chemical substances in household food waste provide significant nutritional advantages. These compounds can be extracted through a variety of techniques, encompassing both traditional methods and innovative green approaches such as enzymatic, microwave, or supercritical fluid extractions. The versatility of these extracted bioactive compounds is demonstrated by their wide-ranging applications across numerous sectors, including textiles, cosmetics, nutraceuticals, food additives, and agriculture. Furthermore, the integration of AI, robotics, IoT, and big data into waste management has revolutionized the sector, enhancing operational efficiency, automating processes, and ensuring timely waste collection and disposal. Although there are advantages to these approaches, challenges persist such as elevated extraction expenses, suboptimal yields, and safety considerations. In order to unlock the complete potential of domestic food waste, an efficiently organized waste management system at the household level is imperative. Further research is necessary to enhance the efficiency of these procedures.</p>
</sec>
</body>
<back>
<sec id="s10">
<title>Author contributions</title>
<p>FS: conceptualization, validation, and writing&#x2013;review and editing. ZA: visualization and writing&#x2013;original draft. MA: validation and writing&#x2013;review and editing. KM: conceptualization and writing&#x2013;original draft. AG: validation and writing&#x2013;review and editing.</p>
</sec>
<sec sec-type="funding-information" id="s11">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<ack>
<p>The authors are highly obliged to their department and institute for access to journals, books, and valuable database.</p>
</ack>
<sec sec-type="COI-statement" id="s12">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s13">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors, and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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