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<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Environ. Sci.</journal-id>
<journal-title>Frontiers in Environmental Science</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Environ. Sci.</abbrev-journal-title>
<issn pub-type="epub">2296-665X</issn>
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<publisher-name>Frontiers Media S.A.</publisher-name>
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<article-id pub-id-type="publisher-id">1402893</article-id>
<article-id pub-id-type="doi">10.3389/fenvs.2024.1402893</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Environmental Science</subject>
<subj-group>
<subject>Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>A review of environmental and health effects of synthetic cosmetics</article-title>
<alt-title alt-title-type="left-running-head">Wirtu</alt-title>
<alt-title alt-title-type="right-running-head">
<ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fenvs.2024.1402893">10.3389/fenvs.2024.1402893</ext-link>
</alt-title>
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<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Wirtu</surname>
<given-names>Yohannes Desalegn</given-names>
</name>
<xref ref-type="corresp" rid="c001">&#x2a;</xref>
<uri xlink:href="https://loop.frontiersin.org/people/2569568/overview"/>
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<role content-type="https://credit.niso.org/contributor-roles/data-curation/"/>
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<aff>
<institution>Department of Environmental Science</institution>, <institution>College of Natural Sciences</institution>, <institution>Madda Walabu University</institution>, <addr-line>Oromia</addr-line>, <country>Ethiopia</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>
<bold>Edited by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/899876/overview">Antonije Onjia</ext-link>, University of Belgrade, Serbia</p>
</fn>
<fn fn-type="edited-by">
<p>
<bold>Reviewed by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1321091/overview">Slavica Ra&#x17e;i&#x107;</ext-link>, University of Belgrade, Serbia</p>
<p>
<ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1855863/overview">Milica Lu&#x10d;i&#x107;</ext-link>, University of Belgrade, Serbia</p>
<p>
<ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1904277/overview">Aleksandra Nastasovi&#x107;</ext-link>, University of Belgrade, Serbia</p>
</fn>
<corresp id="c001">&#x2a;Correspondence: Yohannes Desalegn Wirtu, <email>yohannisdesalegn@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="epub">
<day>22</day>
<month>10</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>12</volume>
<elocation-id>1402893</elocation-id>
<history>
<date date-type="received">
<day>18</day>
<month>03</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>20</day>
<month>09</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2024 Wirtu.</copyright-statement>
<copyright-year>2024</copyright-year>
<copyright-holder>Wirtu</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<p>The use of cosmetic products is expanding globally, and with it, so is the range of chemical substances employed in their production. As a result, there is also a higher risk of intoxication, allergic reactions, prolonged chemical exposure, adverse effects, and indiscriminate use. Cosmetic products can contain more than 10,000 ingredients. Most users of synthetic cosmetics are unaware of the harmful effects if they even are. However, it is linked to many diseases like cancer, congenital disabilities, reproductive impairments, developmental systems, contact dermatitis, hair loss, lung damage, old age, skin diseases and reactions, allergies, and harm to human nails. Many beauty products also create a high demand for natural oils, leading to extensive and intensive cultivation, harming natural habitats through deforestation, and contaminating soil and water through pesticides and fertilizers. The adverse effects of hazardous substances in synthetic cosmetics extend beyond human health and influence ecosystems, air quality, and oceans. Thus, this review aims to assess the environmental and health impacts of cosmetics using published scientific articles. The study used a systematic review based on Scopus, Science Direct, Web databases, Scholar Google, and PubMed. The results of this review showed that the formulation of cosmetics until the disposal of their containers could adversely affect environmental and human health.</p>
</abstract>
<abstract abstract-type="graphical">
<title>Graphical Abstract</title>
<p>
<graphic xlink:href="FENVS_fenvs-2024-1402893_wc_abs.tif" position="anchor"/>
</p>
</abstract>
<kwd-group>
<kwd>cosmetic pollution</kwd>
<kwd>cosmetic impact</kwd>
<kwd>cosmetics and human health</kwd>
<kwd>cosmetic products</kwd>
<kwd>environmental impact</kwd>
<kwd>health risks</kwd>
<kwd>synthetic cosmetics</kwd>
<kwd>waste management</kwd>
</kwd-group>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Toxicology, Pollution and the Environment</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1">
<title>1 Introduction</title>
<p>The market size of the beauty sector, which is estimated to be $48.8 billion and is still expanding, is enormous. People frequently use makeup to express who they are; individuality and self-expression are significant facets of who we are. However, the effects of the cosmetics business and its products on the environment are significant and cannot be disregarded. The beauty sector has substantial environmental consequences, from excessive packaging waste to the utilization of natural resources like palm and soy. Beauty packaging generates 120 billion garbage units annually, including plastic, paper, glass, and metals that are inadequately recycled and ultimately wind up in landfills, according to the social justice platform It should be emphasized that the Traceability and Verification System is the UNICEF Supply Division. The demand for natural oils from several cosmetic goods also increases, which encourages vast and intense farming, damages natural ecosystems through deforestation, and contaminates soil and water with pesticides and fertilizers (<xref ref-type="bibr" rid="B80">Gutierrez, 2023</xref>).</p>
<p>Any substance that is poured, sprinkled, sprayed, inserted into, or otherwise applied to the human body is a cosmetic (<xref ref-type="bibr" rid="B18">Attard and Abstract, 2022</xref>) and is used to clean, beautify, promote attractiveness, or alter the appearance without disrupting the body&#x2019;s physiological functions (<xref ref-type="bibr" rid="B95">John Kanayochukwu Nduka, 2019</xref>). The body&#x2019;s physiological processes should not be changed during this process by cosmetics. Cosmetics must be efficient, durable, stable, and safe for human use. They are mixes of certain surfactants, oils, and other substances. It is challenging to monitor the safety of every product, with so many being introduced to the market each season, and certain items can contain carcinogenic chemicals (<xref ref-type="bibr" rid="B7">Alam et al., 2019</xref>).</p>
<p>According to published research, cosmetic products like lipstick, lip gloss, eye shadow, and henna hair color contain high levels of hazardous lead (<xref ref-type="bibr" rid="B98">Kali&#x10d;anin and Velimirovi&#x107;, 2016</xref>; <xref ref-type="bibr" rid="B114">&#x0141;odyga-Chru&#x0158;ci&#x0144;ska et al., 2018</xref>). Triclosan is a common antibiotic likely present in consumer goods and personal care items utilized by 75% of the U.S. population. Following a risk evaluation by the U.S. Food and Drug Administration, Triclosan (TCS) was eliminated from soap products in September 2016 (FDA). Triclosan is still present, but, in high proportions, in various personal care items such as surgical soaps, mouthwash, hand sanitizer, and toothpaste (<xref ref-type="bibr" rid="B204">Weatherly and Gosse, 2017</xref>).</p>
<p>Heavy metals are a common constituent in cosmetic goods (<xref ref-type="bibr" rid="B7">Alam et al., 2019</xref>). According to Velly et al., lead levels in toothpaste were higher than permitted by U.S. and E.U. guidelines (<xref ref-type="bibr" rid="B198">Vella and Attard, 2019</xref>). Polyethylene glycol (PEGs) (favorably used as penetration enhancers), according to Panico et al., may still contain contaminants, including lead, iron, cobalt, nickel, cadmium, and arsenic (<xref ref-type="bibr" rid="B114">&#x0141;odyga-Chru&#x0158;ci&#x0144;ska et al., 2018</xref>) described how lead and nickel were present in lipsticks and powders on the Polish market at levels prohibited by European regulations (<xref ref-type="bibr" rid="B114">&#x0141;odyga-Chru&#x0158;ci&#x0144;ska et al., 2018</xref>).</p>
<p>Most chemicals are included in cosmetic products as preservatives, surfactants, perfumes, stains, etc. These compounds also improve the items&#x2019; quality, properties, and shelf lives while improving user appeal (<xref ref-type="bibr" rid="B149">Pereira and Pereira, 2018</xref>). However, many of these chemicals also have adverse side effects (<xref ref-type="fig" rid="F1">Figure 1</xref>). Clinical symptoms most frequently reported include conjunctivitis, cosmetic acne, photoallergic/toxic, contact dermatitis, hypo/hyperpigmentation, itching, and corrosive scalp injury. These reactions may occur immediately after application or after repeated use (<xref ref-type="bibr" rid="B122">Mestawet et al., 2018</xref>).</p>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption>
<p>Graphic abstract of environmental and health effects of synthetic cosmetics.</p>
</caption>
<graphic xlink:href="fenvs-12-1402893-g001.tif"/>
</fig>
<p>Documents show that natural material extracts were employed previously, but synthetic substances are now frequently found in cosmetic items. Some of these artificial additions may endanger the health of consumers. The underarm and breast area&#x2019;s estrogenic cosmetics are being looked into as a potential source of breast cancer (<xref ref-type="bibr" rid="B10">Amasa et al., 2012</xref>; <xref ref-type="bibr" rid="B165">Rootid et al., 2022</xref>). There have also been reports of birth abnormalities, reproductive issues, and developmental issues (<xref ref-type="bibr" rid="B139">Okereke et al., 2015</xref>; <xref ref-type="bibr" rid="B98">Kali&#x10d;anin and Velimirovi&#x107;, 2016</xref>).</p>
<p>Environmental concerns are another issue with cosmetics. The environmental effect of about $400 billion and the expanding worldwide cosmetics and beauty business ranges from the procurement of raw materials to production, distribution, and trash produced by end-users (<xref ref-type="bibr" rid="B43">Chouhan and Himanshu Vig, 2021</xref>). Cosmetics impact the oceans, the air quality, and the ecosystems that have sustained flora and fauna for thousands of years, in addition to the local landfills filled with mountains of single-use plastics (<xref ref-type="bibr" rid="B212">Young, 2022</xref>). Species are vanishing so that makeup and skincare palettes can be made. In addition to how the items&#x2019; production and disposal affect wildlife, they also suffer directly from 80 percent of the world&#x2019;s population&#x2019;s continued use of animal testing (<xref ref-type="bibr" rid="B58">European Parliament, 2018</xref>).</p>
<p>In contrast to pharmaceutical medications, personal care, and cosmetic items can only be used externally. Due to human activity, such as washing, taking a shower, or taking a bath, they are more likely to enter the environment in large quantities and contribute to more ecological systems. Shampoos, soaps, toothpaste, and shower gels are examples of personal care products that often fall under sanitary practices and should be rinsed off immediately. However, some personal care items, like sanitizers and sunscreen lotion, are leave-on products. Typically, cosmetics are applied to items and left on the skin for at least a few hours (<xref ref-type="bibr" rid="B28">Borowska and Brz&#xf3;ska, 2015</xref>). When cosmetics are removed, washed, or used in the shower, they enter sewage treatment facilities, which are ineffective at eliminating all contaminants from substances in personal care and cosmetic goods (<xref ref-type="bibr" rid="B160">Ray et al., 2020</xref>). As a result, these chemicals gather with sewage sludge, which is subsequently applied to crops as fertilizer, opening up a route for their entry into the food chain (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>).</p>
<p>The most prevalent types of personal care and cosmetic pollutants are organic chemicals (bisphenol-A, p-chloro-m-xylenol, triclosan, grease, fat, and surfactants), which not only harm the aquatic environment but also have an equivalent impact on the plants and human health (<xref ref-type="bibr" rid="B160">Ray et al., 2020</xref>). With the increasing popularity of cosmetics, along with reports of toxicity in products sold globally and their adverse effects on both human health and the environment, it is justifiable to closely examine these issues.</p>
<p>However, cosmetics in developing nations like Ethiopia do not require marketing authorization, unlike medicinal products. In the Western world, most countries have laws and regulations on cosmetic safety and labeling (<xref ref-type="bibr" rid="B26">Bilal et al., 2017</xref>). As is the case in many other nations, the drug regulatory system does not devote much or any effort to safeguarding the general public and the environment from the negative impacts that these products may have. The companies are in charge of ensuring the safety of the cosmetic products; however, due to various factors, these businesses are business-oriented and pay little to no attention to the cosmetic products&#x2019; safety. Some of them include the need to alter test procedures, formulas, packaging, and advertising which could increase sector costs (<xref ref-type="bibr" rid="B10">Amasa et al., 2012</xref>).</p>
<p>Additionally, some customers choose not to read the labels of cosmetic items to determine the ingredients and other essential details before using them (<xref ref-type="bibr" rid="B26">Bilal et al., 2017</xref>). Therefore, the high rate of illiteracy and lax enforcement of laws leave a gap if faulty goods are put onto the market and cause harm to the environment and people. The purpose of this review was to get insight into the effects of harmful substances in synthetic cosmetics on both human health and the environment.</p>
</sec>
<sec id="s2">
<title>2 Approach</title>
<p>This review has selected 215 studies published between 1995 and 2024. An adequate literature analysis has been conducted to examine the most recent data on the chemical components of cosmetics, including epidemiological research addressing risk factors for various diseases. This narrative review considered pertinent studies on synthetic cosmetics, environmental and human health effects, and management issues. The narrative literature review was according to <xref ref-type="bibr" rid="B149">Pereira and Pereira (2018)</xref>. In this review, we used literature published in English (<xref ref-type="bibr" rid="B199">Wan et al., 2024</xref>), and there were no constraints on the year of publication or type of study setting. We also considered some grey literature, including databases and the most recent reports that were released. Case studies, analytical cross-sectional studies, policy review papers, systematic reviews, and other pertinent studies were also considered. Databases including Scopus, Science Direct, Web databases, Scholar Google, PubMed, Environmental Science and Technology, Government and Environmental Organizations, and Regulatory Agencies were employed to access published scientific publications. Grey literature and reference lists for the studies under evaluation were found using Google.</p>
<p>The inclusion criteria for scholarly papers were as follows: Papers should be published in peer-reviewed journals or reputable academic sources, written in English, and provide relevant empirical data, analysis, or theoretical insights on the effects of toxic ingredients in synthetic cosmetics on humans and the environment. They must contain the terms &#x201c;cosmetic pollution,&#x201d; &#x201c;cosmetic toxicity,&#x201d; &#x201c;cosmetic impact,&#x201d; &#x201c;cosmetic intoxication,&#x201d; &#x201c;cosmetic risk,&#x201d; &#x201c;cosmetic danger,&#x201d; &#x201c;cosmetic and human health,&#x201d; or &#x201c;cosmetic side effects.&#x201d; Scientific papers that discussed cosmetic surgery, and cosmetic impact written in a non-English language or had no connection to cosmetic impact items were omitted, as per the exclusion criteria. Reviews and original publications with a toxicological and clinical perspective were among the scientific literature chosen. The primary hazardous chemicals found in cosmetic items are linked to potential health issues in the scientific literature using this technique. The clinical-toxicological connection is made a useful tool to explain and comprehend the adverse effects of using cosmetics through this integrative study, bringing attention to the underutilized use of these items and emphasizing the accompanying health hazards.</p>
<p>The impact of synthetic cosmetics on the environment and health, associated issues, and potential solutions were the focus of this review, which focused on specific studies on the subject. The evidence was compiled and given section by section to make it simple to summarize the results by subject area. Accordingly, the aspects of common toxic chemical compounds that harm human and environmental health are the subject of this article (<xref ref-type="bibr" rid="B183">Siti Zulaikha et al., 2015</xref>). This review consists of five sections as follows:<list list-type="simple">
<list-item>
<p>1. Common Hazardous Chemicals in Synthetic Cosmetics</p>
<list list-type="simple">
<list-item>
<p>- Identification and discussion of chemicals posing risks to health and the environment.</p>
</list-item>
</list>
</list-item>
<list-item>
<p>2. Consequences of Cosmetics on Environment and Human Health</p>
<list list-type="simple">
<list-item>
<p>- Analysis of the impacts of cosmetic use on ecosystems, wildlife, and human wellbeing.</p>
</list-item>
</list>
</list-item>
<list-item>
<p>3. Difficulties in Controlling Substances in Cosmetics</p>
<list list-type="simple">
<list-item>
<p>- Examination of challenges related to regulation, enforcement, and monitoring of cosmetic ingredients.</p>
</list-item>
</list>
</list-item>
<list-item>
<p>4. Management Strategy</p>
<list list-type="simple">
<list-item>
<p>- Proposal of strategies and approaches to mitigate risks associated with cosmetic chemicals.</p>
</list-item>
</list>
</list-item>
<list-item>
<p>5. Conclusion</p>
<list list-type="simple">
<list-item>
<p>- Summary and key findings from the study.</p>
</list-item>
</list>
</list-item>
</list>
</p>
</sec>
<sec id="s3">
<title>3 Result and discussion</title>
<p>
<xref ref-type="fig" rid="F1a">Chart 1</xref> Show trends in publications and citations on Human Health and ecological effects of synthetic cosmetics (2000&#x2013;2023). The data for &#x201c;<xref ref-type="fig" rid="F1a">Chart 1</xref>&#x201d; were obtained from multiple reputable scientific databases, including PubMed, Web of Science, Scopus, and Google Scholar. These databases were chosen due to their comprehensive coverage of scientific literature and their reliability in providing peer-reviewed literature on synthetic cosmetic and their effect.</p>
<p>To gather relevant data, we used specific search strings tailored to identify studies on health and ecological risks associated with cosmetic ingredients. The search strings used are keywords in <xref ref-type="fig" rid="F2">Figure 2</xref>. The search results were filtered to include peer-reviewed articles and reviews published within the last decade. Data were extracted from the selected studies and categorized into health and ecological risks. Synthesizing this data to provide a comprehensive overview of the trends, which were then visualized in &#x201c;<xref ref-type="fig" rid="F1a">Chart 1</xref>.&#x201d;</p>
<fig id="F1a" position="float">
<label>CHART 1</label>
<caption>
<p>Treand in publications and citations on human health and ecological effects of synthetic cosmetics (2000&#x2013;2023).</p>
</caption>
<graphic xlink:href="fenvs-12-1402893-fx1.tif"/>
</fig>
<fig id="F2" position="float">
<label>FIGURE 2</label>
<caption>
<p>Systematic protocol for retrieving the datasets.</p>
</caption>
<graphic xlink:href="fenvs-12-1402893-g002.tif"/>
</fig>
<p>The Chart titled &#x201c;Trend in publication and citations on human health and ecological effects of synthetic cosmetics (2000&#x2013;2023)&#x201d; illustrates the academic interest and impact of research in this field over 23&#xa0;years. Publications addressing human health effects are depicted with a blue line, while those addressing environmental effects are shown with a grey line. The trends illustrate the growing academic interest and impact in these fields over the past two decades. The data is divided into four categories: Human health risk publications, Human health risk citations, Ecological risk publications, and Ecological risk citations.</p>
<sec id="s3-1">
<title>3.1 Human health risk publications (blue line)</title>
<p>The blue line represents the number of publications focused on human health risks associated with synthetic cosmetics. Over the years, this number has remained relatively stable, with minor fluctuations. The number of publications typically stays below 100&#xa0;per year, indicating a constant but modest level of research activity in this area. This suggests that while there is ongoing interest, the volume of new research published annually has not seen significant growth.</p>
</sec>
<sec id="s3-2">
<title>3.2 Human health risk citations (red line)</title>
<p>The red line shows the number of citations for publications on human health risks. Unlike the steady trend in publications, citations exhibit significant fluctuations. Notable peaks occur around 2008 and 2018, indicating periods of heightened academic or public interest in these studies. These spikes may be linked to regulatory changes, high-profile studies, or increased public awareness. However, there is a sharp decline in citations after 2020, suggesting a decrease in the impact or relevancy of earlier studies in recent years.</p>
</sec>
<sec id="s3-3">
<title>3.3 Ecological risk publications (gray line)</title>
<p>The grey line represents publications on the ecological risks of synthetic cosmetics. These publications are consistently fewer in number compared to those on human health risks, remaining below 50 per year. The trend is relatively flat, showing little variation over the years. This indicates that ecological concerns have not significantly driven an increase in research output, possibly reflecting either a lower priority or fewer resources allocated to this area compared to human health.</p>
</sec>
<sec id="s3-4">
<title>3.4 Ecological risk citation (yellow line)</title>
<p>The yellow line tracks citations of ecological risk publications. Citation in this category also shows high peaks, particularly around 2008 and 2018, similar to the pattern observed for human health risk citation but with a much higher magnitude. This suggests that during these peak years, studies on ecological risks had a significant academic or public impact. Following these peaks, there, is a notable decline in citations after 2020, which may indicate a shift in the research focuses or a decrease in the perceived relevance of previous studies.</p>
<p>The overall trend depicted in the chart reveals that while the number of publications on human health and ecological risks od synthetic cosmetics has been stable and relatively low, the impact of these publications, as measured by citations, has experienced significant fluctuations. Picks in citation numbers around 2008 and 2018 highlight periods of increased attention, possibly due to emerging evidence, regulatory changes, or heightened public concern. However, the decline in citations post-2020 suggests shifting interest or a saturation point in the field, where newer studies may be needed to reignite academic and public interest.</p>
</sec>
<sec id="s3-5">
<title>3.5 Databases and sources for health risk trends</title>
<p>
<list list-type="simple">
<list-item>
<p>1. PubMed: A comprehensive database of biomedical literature, PubMed contains numerous studies on the health effects of cosmetic ingredients such as parabens, UV filters, and fragrances. Researchers and healthcare professionals frequently use this database to access peer-reviewed articles on allergic reactions, endocrine disruption, and other health impacts.</p>
</list-item>
<list-item>
<p>2. Scopus: Scopus offers extensive coverage of scientific, technical, medical, and social science research. It includes articles on the long-term health effects of various cosmetic ingredients, regulatory updates, and emerging trends in toxicology and public health.</p>
</list-item>
<list-item>
<p>3. Web of Science: This multidisciplinary database provides access to research articles, conference proceedings, and reviews. It is useful for tracking the latest studies on the health risks of cosmetic ingredients and understanding the evolving landscape of regulatory science.</p>
</list-item>
<list-item>
<p>4. Regulatory Agencies: Regulatory bodies such as the U.S. Food and Drug Administration (FDA), European Chemicals Agency (ECHA), and Health Canada publish guidelines, safety assessments, and updates on restricted or banned substances in cosmetics. These sources provide authoritative information on regulatory trends and health risk assessments.</p>
</list-item>
</list>
</p>
</sec>
<sec id="s3-6">
<title>3.6 Databases and sources for ecological risk trends</title>
<p>
<list list-type="simple">
<list-item>
<p>1. Environmental Science Databases: Databases like Environmental Science and Technology (ES&#x26;T) and the Journal of Environmental Management publish research on the environmental impacts of cosmetic ingredients, including their persistence, bioaccumulation, and toxicity to aquatic life.</p>
</list-item>
<list-item>
<p>2. Google Scholar: A freely accessible web search engine that indexes scholarly articles across various disciplines. It provides access to studies on the ecological effects of ingredients like triclosan, microplastics, and UV filters.</p>
</list-item>
<list-item>
<p>3. ScienceDirect: An extensive database offering access to a large collection of scientific and technical research articles. It covers studies on the environmental behavior and risks of cosmetic ingredients.</p>
</list-item>
<list-item>
<p>4. Government and Environmental Organizations: Reports and publications from organizations such as the U.S. Environmental Protection Agency (EPA), the European Environment Agency (EEA), and the United Nations Environment Programme (UNEP) provide data and analyses on the ecological risks of cosmetic ingredients.</p>
</list-item>
</list>
</p>
</sec>
<sec id="s3-7">
<title>3.7 How the trends are based</title>
<sec id="s3-7-1">
<title>3.7.1 Health risks</title>
<p>The trends in health risks are based on a synthesis of findings from clinical studies, toxicological research, and regulatory assessments. These include experimental data on allergic reactions, long-term exposure effects, and endocrine disruption, as well as updates from regulatory bodies on banned or restricted substances.</p>
</sec>
<sec id="s3-7-2">
<title>3.7.2 Ecological risks</title>
<p>The trends in ecological risks are derived from environmental monitoring studies, ecotoxicological research, and reports on the persistence and bioaccumulation of cosmetic ingredients in ecosystems. These studies provide insights into how these substances affect aquatic life, microbial communities, and overall ecosystem health.</p>
</sec>
</sec>
<sec id="s3-8">
<title>3.8 Health and ecological risks of cosmetic ingredients</title>
<sec id="s3-8-1">
<title>3.8.1 Health risks of cosmetic ingredients</title>
<p>Cosmetic ingredients, while enhancing appearance and personal hygiene, can pose significant health risks to consumers. These risks range from immediate allergic reactions to long-term health concerns, including hormonal disruptions and chronic illnesses. Understanding these risks is crucial for making informed choices about cosmetic products.</p>
<sec id="s3-8-1-1">
<title>3.8.1.1 Increase in allergic reactions due to parabens and fragrances</title>
<p>Parabens, commonly used as preservatives in cosmetics, have been linked to an increase in allergic reactions. These compounds can cause skin irritation, rashes, and other dermatological issues, especially in individuals with sensitive skin (<xref ref-type="bibr" rid="B158">Rastogi et al., 1995</xref>; <xref ref-type="bibr" rid="B214">Zareba et al., 2007</xref>). Fragrances, another prevalent ingredient in cosmetics, are also major allergens. Studies have shown that fragrances can cause contact dermatitis and exacerbate conditions like eczema and asthma.</p>
</sec>
<sec id="s3-8-1-2">
<title>3.8.1.2 Long-term health effects of UV filters and endocrine disruptors</title>
<p>UV filters, such as oxybenzone and octinoxate, are essential in protecting skin from harmful UV radiation. However, these chemicals are also known as endocrine disruptors, capable of interfering with hormone function. Long-term exposure to UV filters has been associated with reproductive issues, developmental problems, and an increased risk of certain cancers. Endocrine disruptors in cosmetics, including phthalates and bisphenol A (BPA), similarly pose risks, affecting thyroid function and metabolic processes over time (<xref ref-type="bibr" rid="B108">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B112">Liu et al., 2021</xref>).</p>
</sec>
<sec id="s3-8-1-3">
<title>3.8.1.3 Regulatory updates on banned or restricted substances</title>
<p>Regulatory bodies worldwide are continually updating lists of banned or restricted substances in cosmetics to protect public health. For instance, the European Union&#x2019;s Scientific Committee on Consumer Safety (SCCS) regularly reviews and restricts the use of harmful chemicals like certain parabens, formaldehyde-releasing preservatives, and specific UV filters (<xref ref-type="bibr" rid="B174">Scientific Committee on Consumer Safety, 2021</xref>). These regulatory changes aim to mitigate the risks posed by toxic cosmetic ingredients and promote safer alternatives.</p>
</sec>
</sec>
<sec id="s3-8-2">
<title>3.8.2 Ecological risks of cosmetic ingredients</title>
<p>Cosmetic ingredients not only affect human health but also pose significant ecological risks. These substances can accumulate in the environment, disrupting ecosystems and harming wildlife. Understanding these risks is essential for developing sustainable cosmetic products.</p>
<sec id="s3-8-2-1">
<title>3.8.2.1 Bioaccumulation and persistence of parabens and UV filters in aquatic environments</title>
<p>Parabens and UV filters once washed off the skin, enter aquatic environments through wastewater. Studies have shown that these chemicals persist in water bodies, bioaccumulate in aquatic organisms, and disrupt endocrine functions in fish and other wildlife (<xref ref-type="bibr" rid="B31">Brausch and Rand, 2011</xref>). The long-term environmental persistence of these substances raises concerns about their cumulative impact on aquatic ecosystems (<xref ref-type="bibr" rid="B190">Ullah et al., 2017</xref>).</p>
</sec>
<sec id="s3-8-2-2">
<title>3.8.2.2 Impact of triclosan and other antimicrobials on microbial communities and aquatic life</title>
<p>Triclosan, an antimicrobial agent used in many personal care products, has been found to adversely affect microbial communities in aquatic environments. This disruption can lead to antibiotic resistance and negatively impact the health of aquatic life. Research indicates that triclosan can impair reproduction and development in fish, amphibians, and invertebrates (<xref ref-type="bibr" rid="B113">Liu and Wong, 2013</xref>).</p>
</sec>
<sec id="s3-8-2-3">
<title>3.8.2.3 Studies on the effects of microplastics from exfoliants on marine ecosystems</title>
<p>Microplastics, often used in exfoliating products, pose a significant threat to marine ecosystems. These tiny plastic particles are ingested by marine organisms, leading to physical harm, chemical contamination, and disruption of feeding behaviors. Studies have documented the presence of microplastics in various marine species, indicating widespread ecological impact and highlighting the need for biodegradable alternatives (<xref ref-type="bibr" rid="B67">Gago et al., 2018</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s3-9">
<title>3.9 Toxic ingredients in cosmetics</title>
<p>A significant issue in the cosmetics industry is the general lack of consumer awareness about the various chemicals that these products contain. Many individuals are unaware that cosmetics often include a multitude of chemicals, each with its specific purpose. Some of these chemicals can pose risks to our health and the environment. Although not every chemical in cosmetics is harmful, it is crucial to understand the ingredients in the products we use. Opting for products with natural or organic ingredients when possible is a good practice. By educating ourselves about the common chemicals in cosmetics, we can make more informed decisions and take proactive measures to protect both our health and the environment (<xref ref-type="bibr" rid="B130">National Institute of Environmental Health Sciences, 2007</xref>; <xref ref-type="bibr" rid="B174">Scientific Committee on Consumer Safety, 2021</xref>).</p>
<p>The usage of substances with preservative action, surfactants, perfumes, stains, etc., has expanded today due to innovation, research, and the development of new cosmetic goods (<xref ref-type="bibr" rid="B146">Park, 2023</xref>). These ingredients improve the caliber, functionality, and shelf life of cosmetic formulations, but many of them also pose a risk to human health due to frequent, prolonged, and indiscriminate exposure (<xref ref-type="bibr" rid="B206">Whitacre, 2015</xref>). Several organizations on a global scale govern the manufacture, quality control, and safety of cosmetic items (<xref ref-type="bibr" rid="B59">European Union, 2009</xref>; <xref ref-type="bibr" rid="B191">UNI EN ISO 22716, 2014</xref>; <xref ref-type="bibr" rid="B30">Boyer et al., 2017</xref>; <xref ref-type="bibr" rid="B180">Sherrow, 2018</xref>). These organizations are in charge of modifying the standards and recommendations for the population&#x2019;s safe and healthy use of these products while reducing health hazards (<xref ref-type="bibr" rid="B174">Scientific Committee on Consumer Safety, 2021</xref>).</p>
<p>Various organizations, including government agencies (<xref ref-type="bibr" rid="B68">GAO, 2009</xref>; <xref ref-type="bibr" rid="B161">Raymond and Krupnick, 2016</xref>; <xref ref-type="bibr" rid="B152">Practices et al., 2021</xref>), environmental groups (<xref ref-type="bibr" rid="B16">Asfaw et al., 2017</xref>), research institutions (<xref ref-type="bibr" rid="B11">Ananthapavan et al., 2021</xref>), and industry associations (<xref ref-type="bibr" rid="B162">Ricardo, 2021</xref>), may conduct cost-benefit analyses (CBAs) or control CBAs related to toxic ingredients and their impacts on human health and the environment (<xref ref-type="bibr" rid="B14">Arct and Mieloch, 2020</xref>). These analyses aim to assess the economic costs and benefits associated with the use of toxic ingredients in products and their potential adverse effects on human health. For example, they may assess the costs and benefits of implementing stricter regulations or bans on certain toxic substances to protect public health.</p>
<p>Cost-benefit analysis plays a crucial role in decision-making processes related to toxic ingredients and their impacts on human health and the environment. By quantifying the economic costs and benefits of different policy options or management strategies, CBAs help stakeholders make informed decisions that balance environmental protection, public health, and economic considerations (<xref ref-type="bibr" rid="B162">Ricardo, 2021</xref>).</p>
<p>However, no single organization controls the cost-benefit analysis and ensures user safety when harmful compounds are added to cosmetic items (<xref ref-type="bibr" rid="B21">Barthe et al., 2021</xref>).</p>
<p>In the creation of numerous cosmetic goods around the world, several compounds have the potential to be hazardous to both human health and the environment. We also looked at potential health issues associated with cosmetic use and its harmful ingredients.</p>
<p>Cosmetic products like creams, lotions, soaps, lipsticks, mascaras, eye shadows, nail polishes, shampoos, hair dyes, sprays, gels, deodorants, and fragrances may contain ingredients such as triclosan, parabens, phthalates, sodium lauryl sulfate or sodium laureth sulfate (SLS or SLES), mineral oil, formaldehyde, and butylated compounds like butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) (<xref ref-type="bibr" rid="B3">Ad and Mn, 2019</xref>; <xref ref-type="bibr" rid="B20">Barabasz et al., 2019</xref>; <xref ref-type="bibr" rid="B176">Scott Faber, 2020</xref>). About 12,500 industrial chemicals, including carcinogens, insecticides, reproductive poisons, endocrine disruptors, plasticizers, degreasers, and surfactants, were identified by U.S. researchers as being used as cosmetic additives (<xref ref-type="bibr" rid="B132">Naveed, 2014</xref>; <xref ref-type="bibr" rid="B179">Sheikh AG, 2018</xref>; <xref ref-type="bibr" rid="B104">Lauren, 2019</xref>). According to the Cosmetic Ingredient Review (CIR), an estimated 12,500 chemicals are used in cosmetics in the U.S. Only 11 of these chemicals are prohibited in the U.S. Still, more than 1,300 are banned or restricted in the E.U. (<xref ref-type="bibr" rid="B124">Milman, 2019</xref>) Several types of cosmetics have been identified to contain aluminum, a lightweight metal, in addition to heavy metals like lead, mercury, cadmium, arsenic, and nickel. These metals are commonly found in color cosmetics, face and body care products, hair cosmetics, herbal cosmetics, and similar items (<xref ref-type="bibr" rid="B97">Kader Mohiuddin, 2019</xref>). For a variety of reasons, heavy metals are also added to cosmetics. It is commonly known that heavy metals are harmful (<xref ref-type="bibr" rid="B183">Siti Zulaikha et al., 2015</xref>).</p>
</sec>
<sec id="s3-10">
<title>3.10 Environmental and health effects of cosmetics</title>
<sec id="s3-10-1">
<title>3.10.1 Health effects of cosmetics</title>
<p>Cosmetic compounds are emerging environmental contaminants that are hazardous to human health (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>).</p>
<p>People encounter toxic metals through multiple exposure pathways. Many consumers use these products daily and thereby expose themselves to the risk of these toxic metals. Numerous studies have shown that cosmetics components may harm the environment (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>; <xref ref-type="bibr" rid="B92">Issac and Kandasubramanian, 2021</xref>; <xref ref-type="bibr" rid="B212">Young, 2022</xref>) and human health (<xref ref-type="bibr" rid="B139">Okereke et al., 2015</xref>; <xref ref-type="bibr" rid="B133">Nduka and Kelle, 2018</xref>; <xref ref-type="bibr" rid="B3">Ad and Mn, 2019</xref>). It has been documented that the use of cosmetics can cause cancer, mutation, reproductive damage, and endocrine disruption (<xref ref-type="bibr" rid="B10">Amasa et al., 2012</xref>). Some chemicals used in personal care products can negatively affect the hormone system, even at low concentrations (<xref ref-type="bibr" rid="B196">Vandenberg et al., 2012</xref>; <xref ref-type="bibr" rid="B137">NYS Health Foundation, 2013</xref>). Endocrine-disrupting substances like parabens and phthalates may be most dangerous during fetal and early postnatal development when organ and neurological systems are forming (<xref ref-type="bibr" rid="B65">Francisco et al., 2012</xref>; <xref ref-type="bibr" rid="B129">Nassan et al., 2017</xref>; <xref ref-type="bibr" rid="B29">Bouyssi-Kobar et al., 2019</xref>; <xref ref-type="bibr" rid="B4">Adegoke et al., 2021</xref>). Endocrine disorders and several types of cancer have been related to exposure to these substances. For instance, endocrine disruptors have been associated with breast cancer since it is known that they alter how women&#x2019;s bodies use estrogen. Endocrine disruptors have also been linked to immune system damage, which increases susceptibility to health problems (<xref ref-type="bibr" rid="B4">Adegoke et al., 2021</xref>). Many cosmetics have also been connected to severe hazards like infections and burns (<xref ref-type="bibr" rid="B27">Biskanaki et al., 2023</xref>). Hair loss, blisters, nosebleeds, bleeding gums, and a loss of taste and smell have all been connected to formaldehyde-based on &#x201c;keratin treatments,&#x201d; which are used to straighten hair (<xref ref-type="bibr" rid="B176">Scott Fabber, 2020</xref>). Plenty of proof exists indicating that personal care items are tainted with heavy metals, as reported by Siti Zulaikha and co-authors in 2015, along with supporting visual data (<xref ref-type="bibr" rid="B183">Siti Zulaikha et al., 2015</xref>).</p>
<p>More than 10,000 chemicals can be found in cosmetic products (<xref ref-type="bibr" rid="B98">Kali&#x10d;anin and Velimirovi&#x107;, 2016</xref>). The European Union has stricter rules, and its precautionary approach recognizes that substances linked to cancer and birth abnormalities are not allowed to be added to cosmetics. A total of 1,328 substances known or suspected of causing cancer, genetic mutation, reproductive damage, or birth defects are prohibited from cosmetics under E.U. regulation. Comparatively, the U.S. FDA has only forbidden or limited the use of 11 substances in cosmetics. European Union legislation, in contrast to American law, mandates pre-market safety evaluations of cosmetics, mandatory registration of cosmetic products, government approval for the use of nanomaterials, and outlaws the use of animals in cosmetic testing (<xref ref-type="bibr" rid="B59">European Union, 2009</xref>; <xref ref-type="bibr" rid="B61">FDA, 2022</xref>; <xref ref-type="bibr" rid="B141">Onel et al., 2019</xref>; <xref ref-type="bibr" rid="B69">Gautam et al., 2022</xref>).</p>
<p>Heavy metals such as lead, arsenic, mercury, aluminum, zinc, chromium, and iron are found in various personal care products like lipstick, whitening toothpaste, eyeliner, and nail polish (<xref ref-type="bibr" rid="B183">Siti Zulaikha et al., 2015</xref>). While some metals are added deliberately as ingredients, others appear as contaminants. These metals pose significant risks to human health and the environment.</p>
<p>Lead: Lead exposure from cosmetics has been linked to various health issues, including developmental delays in children, reproductive problems (<xref ref-type="bibr" rid="B52">Environmental, 2019</xref>), and neurological damage. Chronic exposure to lead can lead to kidney damage, hypertension, and impaired cognitive function.</p>
<p>Mercury: Mercury is a potent neurotoxin that can accumulate in the body over time, leading to neurological disorders, kidney damage, and skin rashes. Prolonged mercury exposure can also impair cognitive function and affect fetal development in pregnant women (<xref ref-type="bibr" rid="B53">EPA, 2001</xref>).</p>
<p>Cadmium: Cadmium exposure from cosmetics has been associated with lung damage, kidney dysfunction, and bone disorders. Long-term exposure to cadmium may increase the risk of cancer and disrupt hormonal balance in the body (<xref ref-type="bibr" rid="B157">Ramelli et al., 2012</xref>; <xref ref-type="bibr" rid="B71">Genchi et al., 2020</xref>; <xref ref-type="bibr" rid="B39">Charkiewicz et al., 2023</xref>).</p>
<p>Arsenic: Arsenic is a carcinogen that can cause skin lesions, respiratory issues, and cardiovascular problems. Chronic exposure to arsenic has been linked to various types of cancer, including skin, lung, bladder, and liver cancer (<xref ref-type="bibr" rid="B144">Palma-Lara et al., 2020</xref>; <xref ref-type="bibr" rid="B185">Speer et al., 2023</xref>).</p>
<p>The presence of these toxic metals in synthetic cosmetics highlights the importance of rigorous testing and regulation to ensure product safety and protect consumer health. Consumers should be aware of the potential risks associated with certain ingredients and prioritize products that are certified to meet safety standards (<xref ref-type="bibr" rid="B33">Canada, 2007</xref>).</p>
</sec>
<sec id="s3-10-2">
<title>3.10.2 Safety assessment of ingredients in cosmetics</title>
<p>Impurities such as heavy metals are frequently found in cosmetic and personal care products. This explains why the concentration of heavy metals found in the products was so low. Their presence in cosmetics does not necessitate their labeling as product contaminants. Even if the harmful metals were only present in trace amounts, they are known to accumulate and cause poisoning. If permitted to build up over time, the gradual release of these metals into the human body could be detrimental to the biological system. Because of these metals&#x2019; lengthy half-lives, they may build up in the body&#x2019;s organs. The uncertainty factor is applied to risk characterization in the last stage of the safety assessment of cosmetic compounds. The MoS is the name given to this uncertainty factor.</p>
<p>The World Health Organization (WHO) generally considers a margin MoS value of 100 as a benchmark for determining the safe use of a substance (<xref ref-type="bibr" rid="B183">Siti Zulaikha et al., 2015</xref>).</p>
</sec>
</sec>
<sec id="s3-11">
<title>3.11 Carcinogenic and non-carcinogenic risk analysis of different harmful substances found in various types of cosmetics</title>
<sec id="s3-11-1">
<title>3.11.1 Non-carcinogenic analysis</title>
<p>Health risks associated with heavy metals are assessed by estimating risk levels and categorizing them as either carcinogenic or non-carcinogenic hazards. So, the hazard index (HI), Systemic Exposure Dosage (SED), and MoS were used to estimate the non-cancer health risks of different harmful substances found in various types of cosmetics.</p>
<p>To assess non-carcinogenic risk, especially from exposure to chemicals, two primary metrics are used: the Hazard Quotient (HQ) and HI. These are commonly applied in human health risk assessments (<xref ref-type="bibr" rid="B134">Nduka et al., 2016</xref>; <xref ref-type="bibr" rid="B56">Eticha et al., 2018b</xref>; <xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>). The HQ value &#x3c; 1 is considered to be safe while that greater than 1 is unsafe for human health. The HQ level was calculated using <xref ref-type="disp-formula" rid="e1">Equation 1</xref>.</p>
<p>Hazard Quotient <inline-formula id="inf1">
<mml:math id="m1">
<mml:mrow>
<mml:mfenced open="(" close=")" separators="&#x7c;">
<mml:mrow>
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</mml:mrow>
</mml:mfenced>
</mml:mrow>
</mml:math>
</inline-formula>: is used to estimate the risk of non-carcinogenic effects from a single substance.<disp-formula id="e1">
<mml:math id="m2">
<mml:mrow>
<mml:mi>H</mml:mi>
<mml:mi>Q</mml:mi>
<mml:mo>&#x3d;</mml:mo>
<mml:mfrac>
<mml:mrow>
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<mml:mi>D</mml:mi>
</mml:mrow>
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<mml:mi>f</mml:mi>
<mml:mi>D</mml:mi>
</mml:mrow>
</mml:mfrac>
</mml:mrow>
</mml:math>
<label>(1)</label>
</disp-formula>The SED value was calculated by an expression:<disp-formula id="e2">
<mml:math id="m3">
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<mml:mfrac>
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<mml:mi>s</mml:mi>
<mml:mo>&#xd7;</mml:mo>
<mml:mi>A</mml:mi>
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<mml:mi>F</mml:mi>
<mml:mo>&#xd7;</mml:mo>
<mml:mi>B</mml:mi>
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</mml:mrow>
<mml:mrow>
<mml:mi>B</mml:mi>
<mml:mi>W</mml:mi>
</mml:mrow>
</mml:mfrac>
<mml:mo>&#xd7;</mml:mo>
<mml:msup>
<mml:mn>10</mml:mn>
<mml:mrow>
<mml:mo>&#x2212;</mml:mo>
<mml:mn>3</mml:mn>
</mml:mrow>
</mml:msup>
</mml:mrow>
</mml:math>
<label>(2)</label>
</disp-formula>where, Reference Dose (RfD): is the maximum acceptable oral dose of toxic substance, established by a regulatory agency like EPA. It represents a daily exposure level that is assumed to be without significant risk of adverse effects on life. SED is the systematic exposure dose, Cs indicates metal concentration in the sample (mg/kg), SSA is the surface area of skin onto which the product is applied (cm<sup>2</sup>), AA shows the quantity applied (g/cm<sup>2</sup>), RF is the retention factor, F indicates the application frequency of a product/day, BF is the bioaccessibility factor, 10<sup>&#x2212;3</sup> (mg/kg) is used as unit conversion factor, BW is the average body weight (70&#xa0;kg) (<xref ref-type="bibr" rid="B56">Eticha et al., 2018b</xref>; <xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>).</p>
<p>HI: is used to estimate the risk of non-carcinogenic effects from exposure to multiple chemical substances (<xref ref-type="disp-formula" rid="e3">Equation 3</xref>) (<xref ref-type="bibr" rid="B56">Eticha et al., 2018b</xref>; <xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>). It is the sum of the Hazard Quotient for all chemicals considered.<disp-formula id="e3">
<mml:math id="m4">
<mml:mrow>
<mml:mtext>HI</mml:mtext>
<mml:mo>&#x3d;</mml:mo>
<mml:mo>&#x2211;</mml:mo>
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<label>(3)</label>
</disp-formula>HQi: The Hazard Quotient for each chemical.</p>
<p>The HI value in sample hydroalcoholic gel samples tested in the study is less than 1. The HI levels were much less than 1, meaning that the samples were safe for human health (<xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>). The study conducted on Health Risk Assessment of some Cosmetic Products sold in Keffi Markets, Nasarawa State Nigeria revealed that HI, pressed powder, dental powder, eye shadow, and eyeliner, 9.61 <inline-formula id="inf2">
<mml:math id="m5">
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</inline-formula> 0<sup>3</sup>, 6.0 <inline-formula id="inf3">
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</inline-formula> 10<sup>4</sup>, 7.2 <inline-formula id="inf4">
<mml:math id="m7">
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</inline-formula> 10<sup>6</sup>, and 1.0 <inline-formula id="inf5">
<mml:math id="m8">
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</mml:mrow>
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</inline-formula> 10<sup>9</sup> respectively. Results are in agreement with those reported by <xref ref-type="bibr" rid="B85">Health Canada (2016)</xref>. HI levels for the lotion and sunblock were greater than 1 at both 50% and 100% bio-accessibility, which demonstrated that excessive use of these products may cause health risks to consumers. In the case of hair dye, foundation, whitening cream, and lipstick, HI values reported by <xref ref-type="bibr" rid="B217">Abed Elaziz et al. (2016)</xref> were also less than 1 for different facial cosmetics.</p>
</sec>
<sec id="s3-11-2">
<title>3.11.2 Carcinogenic analysis</title>
<p>The carcinogenic analysis is realized by the evaluation of the probable cancer risks due to exposure to heavy metals. The ILCR is the incremental probability of a person developing any type of cancer over a lifetime as a result of 24&#xa0;h per day exposure to a given daily amount of a carcinogenic element for 70&#xa0;years. The permissible limits of ILCR for one or more heavy metals are 10<sup>&#x2212;6</sup> &#x3c; ILCR &#x3c;10<sup>&#x2212;4</sup> and computed as reported previously (<xref ref-type="disp-formula" rid="e4">Equation 4</xref>) (<xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>).<disp-formula id="e4">
<mml:math id="m9">
<mml:mrow>
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</mml:math>
<label>(4)</label>
</disp-formula>where SF represents the carcinogenicity slope factor (mg/kg/d)/-1 and it approximates the cancer risk per unit intake dose of an agent to cause cancer over an average lifetime.</p>
<p>The study conducted (<xref ref-type="bibr" rid="B74">Gnonsoro et al., 2022</xref>) on Health Risk Assessment of Heavy Metals (Pb, Cd, Hg) in Hydroalcoholic Gels of Abidjan, C&#xf4;te d&#x2019;Ivoire depicted that the mean values of ILCR for lead and cadmium are 2.59 <inline-formula id="inf6">
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</inline-formula> 10<sup>&#x2212;8</sup> &#xb1; 1.15 <inline-formula id="inf7">
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</inline-formula> 10<sup>&#x2212;8</sup> and 4.78 <inline-formula id="inf8">
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</inline-formula> 10<sup>&#x2212;9</sup> &#xb1; 1.56 <inline-formula id="inf9">
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</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;9</sup> respectively. For a single heavy metal, an ILCR below 1 <inline-formula id="inf10">
<mml:math id="m14">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;6</sup> poses an insignificant cancer risk and can be disregarded, whereas an ILCR exciding 1 <inline-formula id="inf11">
<mml:math id="m15">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;4</sup> signals a significant health concern due to the heightened risk of cancer. Therefore, the hydroalcoholic gel samples tested in the study did not pose a carcinogenic risk through dermal sensitivity for lead and cadmium.</p>
<p>In the context of cosmetic products, assessing carcinogenic risk involves analyzing exposure through ingestion, inhalation, and dermal contact.</p>
<p>Ingestion of cosmetic products generally occurs through incidental ingestion of lip products or accidental ingestion by children. This pathway necessitates careful calculation of doses based on product usage and the concentration of harmful substances, coupled with regulatory measures to limit such substances in lip and oral care products (<xref ref-type="bibr" rid="B61">FDA, 2022</xref>; <xref ref-type="bibr" rid="B168">Salles et al., 2023</xref>).</p>
<p>Inhalation exposure is significant for aerosolized products like sprays, powders, and perfumes. Here, risk factors include the concentration of airborne particles, the frequency of use, and environmental ventilation. Proper risk assessment involves estimating inhalation rates and using inhalation-specific toxicological data, with mitigation strategies such as regulating volatile organic compounds (VOCs) and promoting safe usage practices (<xref ref-type="bibr" rid="B138">Oh and Kim, 2020</xref>; <xref ref-type="bibr" rid="B172">SCCS, 2023</xref>).</p>
<p>Dermal contact is the primary exposure pathway for most cosmetics, which are applied directly to the skin. This involves considering skin permeability, product formulation, and application frequency. The risk is assessed by evaluating the product&#x2019;s concentration, the surface area exposed, and absorption rates, with regulatory measures ensuring the exclusion of known carcinogens and comprehensive safety testing of ingredients (<xref ref-type="bibr" rid="B40">Chedik et al., 2024</xref>).</p>
<p>Integrating these pathways into a comprehensive risk assessment allows for a complete understanding of carcinogenic risks associated with cosmetics, ensuring products meet safety standards and maintain consumer safety and confidence (<xref ref-type="bibr" rid="B34">Canavez et al., 2021</xref>; <xref ref-type="bibr" rid="B33">Canada, 2007</xref>).</p>
<p>Maximum Allowed Limit: Regulatory limits for hazardous metals in various cosmetic products as specified by different health agencies.</p>
<p>Lead (Pb) and Cadmium (Cd) are common hazardous metals found in synthetic cosmetics. <xref ref-type="table" rid="T1">Table 1</xref> provides examples of these metals in various cosmetic products and their associated carcinogenic risk assessments.</p>
<table-wrap id="T1" position="float">
<label>TABLE 1</label>
<caption>
<p>Health risk assessment of hazardous metals in synthetic cosmetics.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Hazardous metal</th>
<th align="left">Example product</th>
<th align="left">Maximum allowed limit</th>
<th align="left">Incremental lifetime cancer risk (ILCR)</th>
<th align="left">References</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">Lead (Pb)</td>
<td align="left">Lip Products</td>
<td align="left">10&#xa0;ppm</td>
<td align="left">2.59 <inline-formula id="inf12">
<mml:math id="m16">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup> &#xb1; 1.15 <inline-formula id="inf13">
<mml:math id="m17">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup>
</td>
<td align="left">
<xref ref-type="bibr" rid="B74">Gnonsoro et al. (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Lead (Pb)</td>
<td align="left">Eye Pencil, Lipstick, Tattoo</td>
<td align="left">10&#xa0;ppm in lip products; 3&#xa0;&#x3bc;g/g for eye pencil, lipstick, and tattoo</td>
<td align="left">2.59 <inline-formula id="inf14">
<mml:math id="m18">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup> &#xb1; 1.15 <inline-formula id="inf15">
<mml:math id="m19">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup>
</td>
<td align="left">
<xref ref-type="bibr" rid="B84">Health Canada (2007)</xref>
</td>
</tr>
<tr>
<td align="left">Cadmium (Cd)</td>
<td align="left">Eye Pencil, Lipstick, Tattoo</td>
<td align="left">3&#xa0;&#x3bc;g/g</td>
<td align="left">4.78 <inline-formula id="inf16">
<mml:math id="m20">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;9</sup> &#xb1; 1.56 <inline-formula id="inf17">
<mml:math id="m21">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;9</sup>
</td>
<td align="left">
<xref ref-type="bibr" rid="B74">Gnonsoro et al. (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Lead (Pb)</td>
<td align="left">Various Cosmetics</td>
<td align="left">Not specified</td>
<td align="left">2.59 <inline-formula id="inf18">
<mml:math id="m22">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup> &#xb1; 1.15 <inline-formula id="inf19">
<mml:math id="m23">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup>
</td>
<td align="left">
<xref ref-type="bibr" rid="B74">Gnonsoro et al. (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Cadmium (Cd)</td>
<td align="left">Various Cosmetics</td>
<td align="left">Not specified</td>
<td align="left">4.78 <inline-formula id="inf20">
<mml:math id="m24">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;9</sup> &#xb1; 1.56 <inline-formula id="inf21">
<mml:math id="m25">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;9</sup>
</td>
<td align="left">
<xref ref-type="bibr" rid="B74">Gnonsoro et al. (2022)</xref>
</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>Including specific examples of carcinogenic risk assessments for hazardous metals in synthetic cosmetics enhances the study&#x2019;s relevance. It provides a clear, detailed understanding of the potential carcinogenic risks and regulatory standards, helping to inform both consumers and regulatory bodies about the safety of cosmetic products.</p>
<p>
<xref ref-type="table" rid="T2">Table 2</xref> also suggests that certain cosmetics, especially eyeshadow, and lipstick, have relatively high HI values for certain metals, indicating a potential risk of adverse health effects from exposure to these metals through cosmetics. This suggests the need for further assessment and possibly regulation to ensure consumer safety.</p>
<table-wrap id="T2" position="float">
<label>TABLE 2</label>
<caption>
<p>MoS, SED, and HQ value of some toxic metal ingredients present in cosmetics products.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Toxic metal ingredients</th>
<th align="left">Type of cosmetic</th>
<th align="left">MoS</th>
<th align="left">SED</th>
<th align="left">HQ</th>
<th align="left">References</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td rowspan="3" align="left">Cd</td>
<td align="left">Lipstick</td>
<td align="left">2.55 <inline-formula id="inf22">
<mml:math id="m26">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup>
</td>
<td align="left">3.92 <inline-formula id="inf23">
<mml:math id="m27">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;5</sup>
</td>
<td align="left">3.5</td>
<td align="left">
<xref ref-type="bibr" rid="B93">Iwegbue et al. (2016),</xref> <xref ref-type="bibr" rid="B189">Tunde (2024)</xref>
</td>
</tr>
<tr>
<td align="left">Eyeshadow (mg/kg/d)</td>
<td align="left">2.37 <inline-formula id="inf24">
<mml:math id="m28">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>7</sup>
</td>
<td align="left">2.11 <inline-formula id="inf25">
<mml:math id="m29">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;10</sup>
</td>
<td align="left">1.6</td>
<td align="left">
<xref ref-type="bibr" rid="B76">Guerranti et al. (2022),</xref> <xref ref-type="bibr" rid="B8">Albugami et al. (2024)</xref>
</td>
</tr>
<tr>
<td align="left">Lotion (mg/kg/d)</td>
<td align="left">1.13 <inline-formula id="inf26">
<mml:math id="m30">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>1</sup>
</td>
<td align="left">4.41 <inline-formula id="inf27">
<mml:math id="m31">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;2</sup>
</td>
<td align="left">0.59</td>
<td align="left">
<xref ref-type="bibr" rid="B15">Arshad et al. (2020)</xref>
</td>
</tr>
<tr>
<td rowspan="4" align="left">Pb</td>
<td align="left">Lipstick</td>
<td align="left">3.02 <inline-formula id="inf28">
<mml:math id="m32">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup>
</td>
<td align="left">1.32 <inline-formula id="inf29">
<mml:math id="m33">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;4</sup>
</td>
<td align="left">5</td>
<td align="left">
<xref ref-type="bibr" rid="B189">Tunde, 2024</xref>; <xref ref-type="bibr" rid="B109">Li et al. (2021)</xref>
</td>
</tr>
<tr>
<td align="left">Dental powder (&#x3bc;g kg-1dw day-1)</td>
<td align="left">2.41</td>
<td align="left">0.1658</td>
<td align="left"/>
<td align="left">
<xref ref-type="bibr" rid="B90">Ibrahim et al. (2019)</xref>
</td>
</tr>
<tr>
<td align="left">Eyeshadow (mg/kg/d)</td>
<td align="left">5.39 <inline-formula id="inf30">
<mml:math id="m34">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>8</sup>
</td>
<td align="left">1.48 <inline-formula id="inf31">
<mml:math id="m35">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup>
</td>
<td align="left">3.2</td>
<td align="left">
<xref ref-type="bibr" rid="B76">Guerranti et al. (2022),</xref> <xref ref-type="bibr" rid="B8">Albugami et al. (2024)</xref>
</td>
</tr>
<tr>
<td align="left">Lotion (mg/kg/d)</td>
<td align="left">8.71 <inline-formula id="inf32">
<mml:math id="m36">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>1</sup>
</td>
<td align="left">4.82 <inline-formula id="inf33">
<mml:math id="m37">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;1</sup>
</td>
<td align="left">1.30</td>
<td align="left">
<xref ref-type="bibr" rid="B15">Arshad et al. (2020)</xref>
</td>
</tr>
<tr>
<td rowspan="4" align="left">Cr</td>
<td align="left">Lipstick</td>
<td align="left">2.76 <inline-formula id="inf34">
<mml:math id="m38">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup>
</td>
<td align="left">1.09 <inline-formula id="inf35">
<mml:math id="m39">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;4</sup>
</td>
<td align="left">4</td>
<td align="left">
<xref ref-type="bibr" rid="B93">Iwegbue et al. (2016),</xref> <xref ref-type="bibr" rid="B189">Tunde et al. (2024)</xref>
</td>
</tr>
<tr>
<td align="left">Dental powder (&#x3bc;g kg-1dw day-1)</td>
<td align="left">6.59</td>
<td align="left">0.0455</td>
<td align="left"/>
<td align="left">
<xref ref-type="bibr" rid="B90">Ibrahim et al. (2019)</xref>
</td>
</tr>
<tr>
<td align="left">Eyeshadow (mg/kg/d)</td>
<td align="left">1.05 <inline-formula id="inf36">
<mml:math id="m40">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>4</sup>
</td>
<td align="left">2.38 <inline-formula id="inf37">
<mml:math id="m41">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;4</sup>
</td>
<td align="left">7.93 <inline-formula id="inf38">
<mml:math id="m42">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;2</sup>
</td>
<td align="left">
<xref ref-type="bibr" rid="B76">Guerranti et al. (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Lotion (mg/kg/d)</td>
<td align="left">3.09 <inline-formula id="inf39">
<mml:math id="m43">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>1</sup>
</td>
<td align="left">4.86 <inline-formula id="inf40">
<mml:math id="m44">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;2</sup>
</td>
<td align="left">0.28</td>
<td align="left">
<xref ref-type="bibr" rid="B15">Arshad et al. (2020)</xref>
</td>
</tr>
<tr>
<td rowspan="3" align="left">Ni</td>
<td align="left">Lipstick</td>
<td align="left">9.29 <inline-formula id="inf41">
<mml:math id="m45">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup>
</td>
<td align="left">2.15 <inline-formula id="inf42">
<mml:math id="m46">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;4</sup>
</td>
<td align="left">5</td>
<td align="left">
<xref ref-type="bibr" rid="B93">Iwegbue et al. (2016),</xref> <xref ref-type="bibr" rid="B189">Tunde et al. (2024)</xref>
</td>
</tr>
<tr>
<td align="left">Eyeshadow (mg/kg/d)</td>
<td align="left">2.65 <inline-formula id="inf43">
<mml:math id="m47">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup>
</td>
<td align="left">8.29 <inline-formula id="inf44">
<mml:math id="m48">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;7</sup>
</td>
<td align="left">4.14 <inline-formula id="inf45">
<mml:math id="m49">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;5</sup>
</td>
<td align="left">
<xref ref-type="bibr" rid="B76">Guerranti et al. (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Lotion (mg/kg/d)</td>
<td align="left">1.21 <inline-formula id="inf46">
<mml:math id="m50">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>3</sup>
</td>
<td align="left">4.45 <inline-formula id="inf47">
<mml:math id="m51">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;1</sup>
</td>
<td align="left">0.90</td>
<td align="left">
<xref ref-type="bibr" rid="B15">Arshad et al. (2020)</xref>
</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="T3" position="float">
<label>TABLE 3</label>
<caption>
<p>Cosmetic ingredients and their health effect.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Toxin</th>
<th align="left">Personal care products containing toxin</th>
<th align="left">Health effect</th>
<th align="left">References</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">Triclosan</td>
<td align="left">Deodorants, mouthwash, hand sanitizer, shaving cream, soaps, fragrances, and toothpaste</td>
<td align="left">Liver fibrosis, triclosan-resistant bacteria, immune system impairment, endocrine disruptor, thyroid function, thyroid homeostasis, and immunological response impairment<break/>There may be a negative impact on the human immune system because high urine triclosan levels are associated with a higher prevalence of allergies and hay fever in youngsters. Cancer-causing factors</td>
<td align="left">
<xref ref-type="bibr" rid="B137">NYS Health Foundation (2013),</xref> <xref ref-type="bibr" rid="B213">Yueh and Tukey (2016),</xref> <xref ref-type="bibr" rid="B204">Weatherly and Gosse (2017),</xref> <xref ref-type="bibr" rid="B160">Ray et al. (2020)</xref>; <xref ref-type="bibr" rid="B175">Scott (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Parabens and their compound (methylparaben, ethylparaben, propylparaben, butylparaben, isopropylparaben, isobutylparaben)</td>
<td align="left">Creams, lotions, lipsticks, other wet cosmetics, powders, antiperspirants, and perfumes</td>
<td align="left">Parabens can potentially be endocrine disruptors and may have immunological or allergic consequences. Human breast cancer cells are shown to become more migratory and aggressive when exposed to parabens <italic>in vitro</italic>. High urine paraben concentrations have also been linked statistically to sperm DNA damage and promote cancerogenic and reduced amounts of reproductive hormones in men</td>
<td align="left">
<xref ref-type="bibr" rid="B153">Prusakiewicz et al. (2007),</xref> <xref ref-type="bibr" rid="B137">NYS Health Foundation (2013),</xref> <xref ref-type="bibr" rid="B20">Barabasz et al. (2019),</xref> <xref ref-type="bibr" rid="B160">Ray et al. (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Formaldehyde</td>
<td align="left">Nail polish, nail glue, eyelash glue, hair gel, hair-smoothing products, baby shampoo, body soap, body wash, and color cosmetics</td>
<td align="left">The National Toxicology Program has designated formaldehyde as a substance known to cause cancer in humans. Nasopharyngeal, sinonasal, and lymphohematopoietic cancers, particularly myeloid leukemia, have all been related to occupational exposure, mainly through respiratory pathways. Causes allergic reactions and eye and respiratory system irritation. Exposure to formaldehyde has been linked to cancer-causing effects and reproductive impacts such as spontaneous abortions, congenital abnormalities, low birth weights, and endometriosis</td>
<td align="left">
<xref ref-type="bibr" rid="B177">Department of Health and Human Services (2016)</xref>, <xref ref-type="bibr" rid="B179">Sheikh AG (2018),</xref> <xref ref-type="bibr" rid="B176">Scott Faber (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Toluene</td>
<td align="left">Toluene is a solvent used in nail polish, nail treatment, hair dyes</td>
<td align="left">High amounts can cause upper respiratory tract irritation, central nervous system depression, and neurobehavioral impairment in humans. Massive exposure may result in fluid buildup in the lungs and respiratory arrest. Toluene affects the developing fetus and is hazardous to the brain and neurological system</td>
<td align="left">
<xref ref-type="bibr" rid="B137">NYS Health Foundation (2013),</xref> <xref ref-type="bibr" rid="B176">Scott Faber (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Phenol</td>
<td align="left">Soap, cleaning lotions</td>
<td align="left">Skin corrosive, impact tumor promoter, local tissue irritation, irregular heartbeat, vomiting, darker urine, liver damage, damage to blood-forming organs, collapse, cause mutagenic and cancerogenic</td>
<td align="left">
<xref ref-type="bibr" rid="B160">Ray et al. (2020)</xref>
</td>
</tr>
<tr>
<td align="left">UV filters and Benzophenone-4</td>
<td align="left">Sunscreens, soap, shampoos, antiperspirants and hair sprays</td>
<td align="left">The harmful impact on reproduction and development, hormonal disorders, and endocrine disruption</td>
<td align="left">
<xref ref-type="bibr" rid="B178">Sharifan and Morse. (2016)</xref>, <xref ref-type="bibr" rid="B160">Ray et al. (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Phthalates/its compounds (dibutyl phthalate (DBP), Di-2-ethyl hexyl phthalate (DEHP), Diethyl phthalate (DEP))</td>
<td align="left">Color cosmetics, fragranced lotions, body washes, hair care products, nail polish</td>
<td align="left">Disrupt the endocrine system in the human reproductive system, adult men&#x2019;s sperm DNA damage from exposure to some phthalates has also been connected</td>
<td align="left">
<xref ref-type="bibr" rid="B137">NYS Health Foundation (2013),</xref> <xref ref-type="bibr" rid="B121">Mesquita et al. (2021)</xref>
</td>
</tr>
<tr>
<td align="left">Butylated compounds (BHA (butylated hydroxylanisole), BHT (butylated hydroxyl toluene))</td>
<td align="left">Lip products, hair products, makeup, sunscreen, antiperspirant/deodorant, fragrance, creams</td>
<td align="left">Cancer, irritability, toxicology of the reproductive and developmental systems, and disruption of the endocrine system. The National Toxicology Program classifies BHA as &#x201c;reasonably presumed to be a human carcinogen.&#x201d;</td>
<td align="left">
<xref ref-type="bibr" rid="B177">Department of Health and Human Services (2016)</xref>, <xref ref-type="bibr" rid="B3">Ad and Mn (2019),</xref> <xref ref-type="bibr" rid="B117">Made Safe (2022)</xref>
</td>
</tr>
<tr>
<td align="left" style="color:#333333">1,4-dioxane</td>
<td align="left">shampoo, liquid soap, bubble bath), hair relaxers</td>
<td align="left">The EPA has classified 1,4-Dioxane, which is produced as a byproduct during production, as a &#x201c;probable human carcinogen.&#x201d; Also noted were organ toxicity and inflammation</td>
<td align="left">
<xref ref-type="bibr" rid="B75">Group (2007),</xref> <xref ref-type="bibr" rid="B137">NYS Health Foundation (2013)</xref>
</td>
</tr>
<tr>
<td align="left">Carbon black</td>
<td align="left">A pigment used in eyeliner, mascara, nail polish, eye shadow, brush-on-brow, lipstick, blushers, rouge, makeup, and foundation</td>
<td align="left">Increases the likelihood of developing lung illness, the prevalence of cardiovascular disease, and induces cancerous growth</td>
<td align="left">
<xref ref-type="bibr" rid="B175">Scott (2020)</xref>
<break/>19 20, 21</td>
</tr>
<tr>
<td align="left">per- and poly-fluoroalkyl substances</td>
<td align="left">sunscreen, foundation, concealer, eyeliner, shaving cream, and hairspray</td>
<td align="left">Injure the unborn child, raise the chance of cancer, compromise the immune system, and mess with hormones</td>
<td align="left">
<xref ref-type="bibr" rid="B176">Scott Faber (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Polyethylene Glycols (PEGs)</td>
<td align="left">used in creams</td>
<td align="left">Genotoxicity and systemic toxicity are possible side effects when used on damaged skin</td>
<td align="left">
<xref ref-type="bibr" rid="B3">Ad and Mn (2019)</xref>
</td>
</tr>
<tr>
<td align="left">Petrolatum</td>
<td align="left">used in hair care products to make<break/>they shine</td>
<td align="left">Petrolatum may contain polycyclic aromatic hydrocarbons (PAHs), which could be linked to cancer, allergies, and skin irritability</td>
<td align="left">
<xref ref-type="bibr" rid="B3">Ad and Mn (2019)</xref>
</td>
</tr>
<tr>
<td align="left">Sodium Lauryl Sulfate (SLS)</td>
<td align="left">toothpaste, shampoos, and lotions</td>
<td align="left">Patients with some types of ulcers may experience longer and more discomfort due to human exposure to 1,4-Dioxane contamination. It is regarded as a lung, skin, and eye irritant, and liver cells, heart muscles, and brain cells are all damaged. It messes with the immune system, affects the eye muscle, and triggers allergic skin reactions. When combined with other chemicals, it is highly reactive and produces molecules that cause cancer</td>
<td align="left">
<xref ref-type="bibr" rid="B137">NYS Health Foundation (2013),</xref> <xref ref-type="bibr" rid="B179">Sheikh AG (2018)</xref>
</td>
</tr>
<tr>
<td align="left">Siloxanes</td>
<td align="left">Deodorant creams</td>
<td align="left">As an endocrine disruptor that interferes with the action of human hormones and a potential reproductive toxin, cyclotetrasiloxane may reduce human fertility</td>
<td align="left">
<xref ref-type="bibr" rid="B139">Okereke et al. (2015)</xref>
</td>
</tr>
<tr>
<td align="left">Lead and related compounds</td>
<td align="left">Lipstick, eye shadow, blush, powders, shampoos, and lotions</td>
<td align="left">It may also impact the reproductive system because it is hepatotoxic, neurotoxic, and nephrotoxic. The system is a potential human carcinogen that affects circulatory and heart health and fetal development through the placenta</td>
<td align="left">
<xref ref-type="bibr" rid="B176">Scott Faber (2020),</xref> <xref ref-type="bibr" rid="B18">Attard and Abstract (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Mercury and related compounds</td>
<td align="left">Skin-lightening creams and soaps</td>
<td align="left">Symptoms of kidney damage include skin rashes, discoloration, scarring, decreased skin resistance to bacterial and fungal infections, anxiety, sadness, and psychosis. Peripheral neuropathy is another side effect, and the developing fetus is particularly affected. When pregnant women eat seafood that contains methylmercury, the mercury can pass from the mother to her infant through breast milk, potentially causing neurodevelopmental impairments to the child</td>
<td align="left">
<xref ref-type="bibr" rid="B215">Zero Mercury Working Group (2010),</xref> <xref ref-type="bibr" rid="B207">WHO, (2011)</xref>; <xref ref-type="bibr" rid="B176">Scott Faber (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Cadmium</td>
<td align="left">Lipsticks, eye shadow, eye makeup, eyebrow pencil</td>
<td align="left">In human tissues, irritant dermatitis builds up before being gradually discharged into the bloodstream. But often, it attaches to keratin. The skeletal, reproductive, metabolic, respiratory, and renal systems are affected systemically. It may induce oxidative stress, which can lead to human cancer and has been linked to osteoporosis, diabetes, lung cancer, and kidney damage. It also accelerates the aging process of the skin</td>
<td align="left">
<xref ref-type="bibr" rid="B89">IARC (1987),</xref> <xref ref-type="bibr" rid="B139">Okereke et al. (2015),</xref> <xref ref-type="bibr" rid="B18">Attard and Abstract (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Nickel</td>
<td align="left">Eye shadow</td>
<td align="left">The respiratory system is impacted by allergens and dermatitis, increasing lung and nose cancer risk. A human carcinogen was also reported</td>
<td align="left">
<xref ref-type="bibr" rid="B5">Ahlstr&#xf6;m et al. (2019),</xref> <xref ref-type="bibr" rid="B18">Attard and Abstract (2022)</xref>
</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>The SED predicts the number of chemicals that enter the human body by various exposure means and is computed as <xref ref-type="disp-formula" rid="e2">Equation 2</xref> (<xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>).</p>
<p>According to the study conducted by <xref ref-type="bibr" rid="B55">Eticha et al. (2018a)</xref>, on the determination of levels and exposure risks of metals in lipsticks, the result revealed that the calculated SED (&#x3bc;g/kg bw/day) and MoS of heavy metals from the lipstick products. The SED of cadmium and zinc from the samples ranged from 7.98 <inline-formula id="inf48">
<mml:math id="m52">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;8</sup> to 1.61 <inline-formula id="inf49">
<mml:math id="m53">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;6</sup>, and 4.02 <inline-formula id="inf50">
<mml:math id="m54">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2013;</sup>5 to 8.04 <inline-formula id="inf51">
<mml:math id="m55">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;5</sup> &#x3bc;g/kg bw/day for 50% and 100% bioaccessibility scenarios (<xref ref-type="bibr" rid="B55">Eticha et al., 2018a</xref>).</p>
<p>The study done in Nigeria on Concentrations and exposure risks of some metals in facial cosmetics indicates the SED of cadmium, lead, and chromium in lipstick samples in the range of 1.96 &#xd7; 10<sup>&#x2212;5</sup> to 3.92 <inline-formula id="inf52">
<mml:math id="m56">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2212;5</sup>, 6.61 <inline-formula id="inf53">
<mml:math id="m57">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2013;5</sup> to 1.13 <inline-formula id="inf54">
<mml:math id="m58">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2013;4</sup>, and 5.43 <inline-formula id="inf55">
<mml:math id="m59">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2013;5</sup> to 1.09 <inline-formula id="inf56">
<mml:math id="m60">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>&#x2013;4</sup> &#x3bc;g/kg bw/day respectively at both 50% and 100% bioaccessibility (<xref ref-type="bibr" rid="B93">Iwegbue et al., 2016</xref>).</p>
<p>At 50% and 100% bioaccessibility, the MoS for cadmium and zinc chromium in lipsticks are 5.10 <inline-formula id="inf57">
<mml:math id="m61">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup> to 2.55 <inline-formula id="inf58">
<mml:math id="m62">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup>, 3.72 <inline-formula id="inf59">
<mml:math id="m63">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>8</sup> to 1.86 <inline-formula id="inf60">
<mml:math id="m64">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>8</sup>, and 5.53 <inline-formula id="inf61">
<mml:math id="m65">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup> to 2.76 <inline-formula id="inf62">
<mml:math id="m66">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup>, respectively (<xref ref-type="bibr" rid="B93">Iwegbue et al., 2016</xref>). The MoS for zinc and cadmium in lipsticks at 50% and 100% bioaccessibility, respectively, is 2.49 <inline-formula id="inf63">
<mml:math id="m67">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup> to 1.24 <inline-formula id="inf64">
<mml:math id="m68">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>6</sup> and 1.25 <inline-formula id="inf65">
<mml:math id="m69">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>9</sup> to 6.27 <inline-formula id="inf66">
<mml:math id="m70">
<mml:mrow>
<mml:mo>&#xd7;</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula> 10<sup>8</sup>, according to (<xref ref-type="bibr" rid="B55">Eticha et al., 2018a</xref>). Nonetheless, the World Health Organization (WHO) states that a product&#x2019;s MoS value is safe to use if it is greater than 100 and that a value up to 100 is acceptable (<xref ref-type="bibr" rid="B93">Iwegbue et al., 2016</xref>; <xref ref-type="bibr" rid="B55">Eticha et al., 2018a</xref>; <xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>).</p>
<p>Another study suggests that in the samples of hair dye, foundation, whitening cream, and lipstick MoS was greater than 100, which revealed that the evaluated samples were safe for use. However, in lotions and sun-blocks- blocks the MoS values for Cd, Cr, and Pb were below 100, which indicated that these products are not safe for use, particularly concerning Heavy metal contamination. In different cosmetic products analyzed (<xref ref-type="bibr" rid="B195">Usman et al., 2021</xref>) levels of MoS were found to be higher than 100 while MoS for lipsticks was almost similar to the previous study as reported by <xref ref-type="bibr" rid="B15">Arshad et al. (2020)</xref> (<xref ref-type="disp-formula" rid="e5">Equation 5</xref>).<disp-formula id="e5">
<mml:math id="m71">
<mml:mrow>
<mml:mi>M</mml:mi>
<mml:mi>O</mml:mi>
<mml:mi>S</mml:mi>
<mml:mo>&#x3d;</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:mi>N</mml:mi>
<mml:mi>O</mml:mi>
<mml:mi>A</mml:mi>
<mml:mi>E</mml:mi>
<mml:mi>L</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>S</mml:mi>
<mml:mi>E</mml:mi>
<mml:mi>D</mml:mi>
</mml:mrow>
</mml:mfrac>
</mml:mrow>
</mml:math>
<label>(5)</label>
</disp-formula>
</p>
<p>Nevertheless, if the amount of metal in the samples is above the WHO&#x2019;s recommended threshold of 100, which indicates that a material is acceptable for use, continued use of the products may cause these metals to accumulate to dangerously high levels in the human body. It is advised that regular monitoring systems and the establishment of maximum allowable levels for heavy metals in cosmetic products be put in place to mitigate any potential dangers to human health linked with the use of cosmetics.</p>
<p>The analysis suggests that while these harmful substances are present in cosmetics, the risks associated with their non-carcinogenic and carcinogenic exposure are relatively low when used as directed. However, it&#x27;s essential to consider cumulative exposure from multiple sources and potential synergistic effects when evaluating overall risk. Additionally, continuous monitoring and regulatory oversight are crucial to ensuring the safety of cosmetic products.</p>
<p>The values in <xref ref-type="table" rid="T2">Table 2</xref> depend on various factors such as cosmetics brand (<xref ref-type="bibr" rid="B15">Arshad et al., 2020</xref>), frequency of use, exposure pathways, and individual factors such as age and health status.</p>
</sec>
<sec id="s3-11-3">
<title>3.11.3 Environmental effects of cosmetics</title>
<p>Cosmetic ingredients can enter the environment through various pathways, including but not limited to, direct discharge (<xref ref-type="bibr" rid="B147">Paulsen, 2015</xref>; <xref ref-type="bibr" rid="B188">Tsiouli and Fytianos, 2023</xref>) from manufacturing facilities (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>) into water bodies, runoff (<xref ref-type="bibr" rid="B140">Oluwole et al., 2020</xref>). from urban areas during rainfall events., leaching from landfills (<xref ref-type="bibr" rid="B50">Ejeromedoghene et al., 2021</xref>; <xref ref-type="bibr" rid="B188">Tsiouli and Fytianos, 2023</xref>) where cosmetic products are disposed of <xref ref-type="bibr" rid="B210">Yadav. (2023)</xref>, and via personal use and disposal practices such as washing off products in sinks and showers (<xref ref-type="bibr" rid="B188">Tsiouli and Fytianos, 2023</xref>). Additionally, microplastics and other solid particles from cosmetic formulations can accumulate in soil and water bodies through wastewater treatment effluent or direct release, further contributing to environmental contamination (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>; <xref ref-type="bibr" rid="B149">Pereira and Pereira, 2018</xref>; <xref ref-type="bibr" rid="B46">David and Niculescu, 2021</xref>; <xref ref-type="bibr" rid="B212">Young, 2022</xref>).</p>
<p>The most significant pathway for cosmetic ingredients to enter the environment is through wastewater discharge (<xref ref-type="bibr" rid="B99">Khalid and Abdollahi, 2021</xref>). This is particularly concerning because wastewater treatment plants may not effectively remove all cosmetic ingredients, leading to their release into aquatic environments (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>). Once in aquatic systems, these compounds can persist, bioaccumulate, and biomagnify through the food chain (<xref ref-type="bibr" rid="B107">Li et al., 2023</xref>). They can also transform more harmful substances through processes like photolysis and oxidation. Ultimately, many of these compounds end up in water bodies such as rivers, lakes, and oceans, where they can have adverse effects on aquatic ecosystems and potentially enter the human food chain through seafood consumption (<xref ref-type="bibr" rid="B72">Ghosh et al., 2023</xref>; <xref ref-type="bibr" rid="B143">Osman et al., 2023</xref>).</p>
<p>They discharge into the atmosphere, water, and soil throughout the production process, posing major environmental dangers. According to a US Government Accountability Office review, nanoparticles with antibacterial capabilities that are never provided in large enough numbers may interfere with the beneficial activity of microorganisms in water treatment facilities and render the suggested water for reuse ineffective. Titanium dioxide nanoparticles used for disinfection and to break down contaminants may also be able to drive other organic transformations and have an impact on atmospheric photochemical processes. Similarly, a study done by the University of Toledo discovered that nano-TiO<sub>2</sub>, a substance that is thought to be near home, lowered the organic processes of microorganisms after an hour of exposure. As a result, it has been proposed that these particles, which wind up at civic sewage treatment plants, might damage creatures that are essential to maintaining the ecosystem (<xref ref-type="bibr" rid="B79">Gupta et al., 2022</xref>).</p>
<p>The effluents from wastewater treatment plants and sewage sludge, which are frequently used as a fertilizer, are probably the most significant sources of pollution. Ultraviolet filters (UVFs), often used in the production of cosmetics, can directly enter water bodies when washed off the skin during recreational activities such as swimming, or bathing, as well as indirectly through wastewater from the use of personal care products, washing clothes, and industrial discharges (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>).</p>
<p>Ultraviolet filters (UVFs) are chemicals used in sunscreens and other cosmetics to protect the skin from harmful ultraviolet radiation. Common UV filters include oxybenzone, octinoxate, and avobenzone.</p>
<p>Ecological risk assessment (ERA) of UV filters, such as oxybenzone, octinoxate, and avobenzone, is a critical area of study due to their widespread use in sunscreens and personal care products. These chemicals are designed to absorb or reflect UV radiation, protecting human skin from harmful effects. However, their release into the environment through activities such as swimming, bathing, and wastewater discharge raises significant ecological concerns.</p>
<p>Ultraviolet filters can be highly toxic to various aquatic organisms. For example, oxybenzone has been shown to cause coral bleaching by promoting viral infections in coral cells, disrupting their symbiotic relationship with algae. This can lead to the loss of coral reefs, which are crucial for marine biodiversity (<xref ref-type="bibr" rid="B208">Wood, 2018</xref>; <xref ref-type="bibr" rid="B123">Miller et al., 2021</xref>; <xref ref-type="bibr" rid="B126">Mozas-Blanco et al., 2023</xref>). Similarly, octinoxate has been found to cause developmental issues in fish and invertebrates, impacting reproduction and population dynamics (<xref ref-type="bibr" rid="B173">Schlumpf et al., 2008</xref>).</p>
<p>Many UV filters are lipophilic, meaning they can accumulate in the fatty tissues of aquatic organisms. This bioaccumulation can lead to biomagnification up the food chain, posing risks to predators, including birds and mammals that consume contaminated fish and invertebrates. Persistent UV filters can remain in the environment for extended periods, further exacerbating their ecological impact (<xref ref-type="bibr" rid="B148">Peng et al., 2017</xref>).</p>
<p>Several UV filters have been identified as endocrine disruptors (<xref ref-type="table" rid="T3">Table 3</xref>). They can interfere with the hormonal systems of aquatic organisms, leading to altered reproductive behaviors, growth patterns, and developmental processes. For instance, studies have shown that UV filters like 4-MBC (4-methylbenzylidene camphor) can affect the endocrine system of fish, leading to decreased fertility and altered sex ratios (<xref ref-type="bibr" rid="B200">Wang et al., 2016</xref>; <xref ref-type="bibr" rid="B83">He et al., 2021</xref>).</p>
<p>Parabens, commonly used as preservatives in cosmetics to inhibit microbial growth, include methylparaben, ethylparaben, and butylparaben. These substances can enter aquatic systems via wastewater, where they pose toxic risks to various forms of aquatic life such as algae, crustaceans, and fish. The endocrine systems of these organisms can be disrupted by parabens, causing reproductive and developmental issues (<xref ref-type="bibr" rid="B126">Mozas-Blanco et al., 2023</xref>). Despite being biodegradable, the pervasive use and continual release of parabens result in their accumulation in the environment, creating long-term ecological risks (<xref ref-type="bibr" rid="B126">Mozas-Blanco et al., 2023</xref>).</p>
<p>Triclosan, an antimicrobial agent found in numerous personal care products like soaps, toothpaste, and deodorants, poses environmental risks (<xref ref-type="table" rid="T3">Table 3</xref>). It can persist in aquatic environments, where its presence is toxic, leading to significant water contamination issues (<xref ref-type="bibr" rid="B6">Al et al., 2016</xref>).</p>
<sec id="s3-11-3-1">
<title>3.11.3.1 Air pollution</title>
<p>Volatile organic compounds (VOCs) are air pollutants found in various cosmetics, including fragrances, deodorants, hair sprays, hair mousses, hair styling gels, nail paint removers, shaving creams, and antiperspirants (<xref ref-type="bibr" rid="B111">Lisa and Benson, 2017</xref>; <xref ref-type="bibr" rid="B193">USEPA, 2021</xref>). According to a recent study, these goods considerably contribute to carbon dioxide emissions (<xref ref-type="bibr" rid="B119">McDonald et al., 2018</xref>). The study found that half of the VOCs released in 33 major cities come from household and cosmetic goods. One study discovered that, in some situations, the VOC from deodorants, hairsprays, and fragrances emit the same quantity of chemical vapors as autos. However, it was noted that the balanced ratio was more a result of decreased pollution from automobiles than increased pollution from cosmetics (<xref ref-type="bibr" rid="B119">McDonald et al., 2018</xref>). Let&#x2019;s not overlook the environmental impact of the numerous components produced from fossil fuels that are used in packaging and beauty products. Carbon pollution is a significant concern even when natural ingredients are extracted and processed in non-sustainable methods.</p>
</sec>
<sec id="s3-11-3-2">
<title>3.11.3.2 Water pollution</title>
<p>Toxic chemicals in beauty products leach from our bodies into the oceans, from our bathrooms to spending hot summer days at the beach. Sometimes dangerous compounds are found in shampoos, sunscreens, creams, and lotions that end up in the environment and endanger wildlife. Every year, 14,000 tons of sunscreen end up in the water and on coral reefs. The immense devastation of coral reefs in the world&#x2019;s oceans is caused in part by oxybenzone. It has been discovered that chemical additives, such as butylated hydroxytoluene (BHT), sodium lauryl sulfate, and butylated hydroxy anisole (BHA), can significantly alter the biochemistry of aquatic life. These poisonous compounds sometimes kill fish, in addition to reducing the animal plankton population. Some of these pollutants remain in the water supply even after sewage treatment (<xref ref-type="bibr" rid="B20">Barabasz et al., 2019</xref>).</p>
</sec>
<sec id="s3-11-3-3">
<title>3.11.3.3 Microbeads</title>
<p>The presence of microplastics in the marine environment is a problem that is receiving more attention and is now acknowledged as one of the growing concerns since it could harm animals and pose hazards to the health of marine ecosystems. Additionally, early research has shown that microplastics are widely distributed in much inland water, with a higher concentration than in the coastal environment (<xref ref-type="bibr" rid="B209">Wu et al., 2018</xref>). Microplastics have become prevalent environmental contaminants in both freshwater and marine ecosystems (<xref ref-type="bibr" rid="B110">Limonta et al., 2019</xref>). Plastic packaging is only one component of the plastic pollution brought on by beauty products. Plastic microbeads are used as exfoliants in body scrubs and other beauty treatments, and they are little plastic flecks no larger than 5&#xa0;mm (<xref ref-type="bibr" rid="B92">Issac and Kandasubramanian, 2021</xref>). Innumerable microplastics flush into water bodies when products that contain microbeads are used. They draw pollutants in when fish ingest them and finally by people. Microbeads exacerbate the already severe plastic pollution problems in the world&#x2019;s oceans. Although the U.S. and the U.K. have outlawed microbead production, they still come across them in some products. Nothing prevents cosmetic firms operating in nations without microbead regulations from utilizing hazardous plastic (<xref ref-type="bibr" rid="B212">Young, 2022</xref>).</p>
</sec>
<sec id="s3-11-3-4">
<title>3.11.3.4 Unsustainable resource consumption</title>
<p>Cosmetics products seriously deplete natural resources. For instance, palm oil, a plant-based ingredient, can be found in more than 2,300 cosmetic products (under 20 various names) (<xref ref-type="bibr" rid="B212">Young, 2022</xref>). Only tropical regions within 10 degrees of the equator support the growth of palm oil. Between 2015 and 2018, vendors in Southeast Asia alone cleared 500 square miles of rainforest due to rising demand for the commodity (<xref ref-type="bibr" rid="B63">Final Countdown, 2018</xref>). Deforestation frequently occurs using fire, which releases tons of carbon dioxide, much more than the trees sequester. Moreover, primates are undoubtedly the direct victims of the widespread degradation of rainforests caused by palm oil. According to Orangutan Foundation International, between 1,000 and 5,000 orangutans are murdered annually in palm oil concessions (<xref ref-type="bibr" rid="B142">Orangutan Foundation International, 2015</xref>). The mica mining sector is rife with deforestation as well. The mineral is frequently used to give cosmetics a shine for 4,249 of the goods evaluated by the Environmental Working Group (EWG), including lipsticks and eye shadows (<xref ref-type="bibr" rid="B182">Singh, 2019</xref>). Furthermore, two of the world&#x2019;s most disadvantaged and underpaid individuals work in both industries, palm oil, and mica extraction from the ground. The processes used in mining, harvesting, and manufacturing require a lot of labor and are frequently done in hazardous environments.</p>
</sec>
<sec id="s3-11-3-5">
<title>3.11.3.5 Transport/logistics of beauty products</title>
<p>The logistics and distribution of cosmetics are environmentally detrimental as well. Many cosmetic items are manufactured abroad, and when they are sent to international markets, a significant carbon footprint is left behind.</p>
<p>915 million tons of carbon dioxide were created by the aviation sector in 2019 alone, accounting for roughly 2% of total CO<sub>2</sub> emissions caused by human activity annually (<xref ref-type="bibr" rid="B94">Jaro&#x161;ov&#xe1; and Pajdlhauser, 2022</xref>) These carbon emissions hasten the effects of global warming, which causes several more environmental issues.</p>
<p>Customers are urged to buy their cosmetics from local vendors or even make their own to stop this practice (<xref ref-type="bibr" rid="B166">Sadie, 2020</xref>).</p>
<p>For instance, short supply chains and transit routes can help minimize emissions (<xref ref-type="bibr" rid="B42">Cherrafi et al., 2022</xref>). Cosmetic enterprises have to pay attention to the spread of possible invasive species through logistical procedures and product movements (<xref ref-type="bibr" rid="B17">Ashdaq et al., 2023</xref>). Organisms that are brought into an environment where they do not normally reside are referred to as invasive species (<xref ref-type="bibr" rid="B171">Scanes, 2017</xref>). Highly aggressive species that have no natural rivals or predators may proliferate and endanger native species by becoming invasive (<xref ref-type="bibr" rid="B136">Nikolovska, 2016</xref>). The composition and operation of ecosystems may occasionally be disturbed by these biological invasions, which can also have significant financial consequences.</p>
<p>Particularly cosmetic businesses that use imported fresh and raw plant-based materials may be vulnerable to this (<xref ref-type="bibr" rid="B44">Cooney, 2004</xref>). To prevent the spread of potentially invasive alien species, businesses should take action. You should take the precautionary principle into account (<xref ref-type="bibr" rid="B35">CBD, 2002</xref>). Arriving items with biological raw materials and fresh ingredients should always be thoroughly inspected visually for potential stowaways (such as insects). If &#x201c;contamination&#x201d; is seen, the offending organism has to be eliminated. The possible measures are the identification of possible gateways for potentially invasive species in the company (i.e., goods entrance), process description and procedure for &#x201c;contaminated&#x201d; material, and development of protocols for documentation of material contamination (<xref ref-type="bibr" rid="B73">Gisp and Jackson, 2007</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s3-12">
<title>3.12 Risks to the biodiversity/flora and fauna of ecosystems</title>
<p>Loss of biodiversity is the term used to describe the reduction in diversity within a species, an ecosystem, a region, or the planet itself (<xref ref-type="bibr" rid="B47">David Elisha and Jebbin Felix, 2020</xref>). Because it undermines ecosystems&#x2019; ability to operate and puts them in danger of disturbance, biodiversity loss is a concern because it negatively affects both individual animals and ecosystems as a whole (<xref ref-type="bibr" rid="B38">Chandellier and Malacain, 2021</xref>). As a result, life on Earth is left with fewer resources and is less able to satisfy its requirements.</p>
<p>Many cosmetic products are made using organic, plant- and animal-derived components (<xref ref-type="bibr" rid="B1">Abattoir, 2015</xref>). These include biologically derived ingredients having beneficial qualities for cosmetic applications, such as essential oils, pigments, and surfactants. Biodiversity is becoming a key concern for the cosmetics sector due to rising customer demand for natural components and sustainable cosmetic products (<xref ref-type="bibr" rid="B57">European Business and Biodiversity Campaign, 2010</xref>).</p>
<p>The production or collection of biological raw materials often has the greatest direct and indirect detrimental consequences on biodiversity. The primary environmental effects include the (indirect) use of land for resource extraction, the exploitation of ecosystems and habitats, pesticide and fertilizer contamination, and agricultural practices that encourage erosion (<xref ref-type="bibr" rid="B203">Wassie, 2020</xref>). A conspicuous illustration of this is the continued destruction of significant portions of primary rainforest for the increasingly widespread cultivation of palm oil (<xref ref-type="bibr" rid="B127">Murphy et al., 2021</xref>). In the case of wild collection, the ecological sustainability of the resource collection is reliant on the good conservation status of the employed species and its population (<xref ref-type="bibr" rid="B105">Leaman, 2008</xref>). Improper harvesting techniques or other factors might have a detrimental impact on preservation. Factors influencing the preservation negatively are improper harvesting methods or harvesting times as a harvesting rate above the regeneration capacity of the species. The Candeia tree <italic>(Eremanthus erythropappus),</italic> which produces the anti-inflammatory alpha-bisabolol, which is used in several skin creams and is native to the Amazonian rainforest, is a good example of this (<xref ref-type="bibr" rid="B154">Queiroz and Cajaiba, 2016</xref>).</p>
<p>There is a possibility of harmful consequences on biodiversity even at the very end of the value chains for cosmetics. For instance, many of the cosmetics&#x2019; active components wind up in sewage water and are incapable of being filtered in typical sewage treatment facilities (<xref ref-type="bibr" rid="B57">European Business and Biodiversity Campaign, 2010</xref>). Such &#x201c;Xenobiotic&#x201d; (bio-incompatible) substances wind up in rivers and streams, where they are likely to accumulate in aquatic creatures and, for example, impair reproduction (<xref ref-type="bibr" rid="B159">Ravindra et al., 2019</xref>).</p>
<p>Since the use of materials from protected or endangered species, as well as biological raw materials and ingredients from areas with high biodiversity can be extremely important to the success of cosmetic companies, corporate management should modify its environmental policy to support the objectives of the UN Biodiversity Convention (<xref ref-type="bibr" rid="B115">Lojeng, 2022</xref>).</p>
<p>Environment and Sustainability Managers as well as auditors should assess to what extent the strategic importance of biodiversity is known as well as anchored in the company (<xref ref-type="bibr" rid="B32">Burby, 2013</xref>). To accomplish this, it is recommended to analyze the corporate mission and environmental policy.</p>
<p>Without appropriate action, the loss of biodiversity will keep accelerating, with unexpected impacts on the economy and society (<xref ref-type="bibr" rid="B47">David Elisha and Jebbin Felix, 2020</xref>). The following elements are the main causes of biodiversity loss on a global scale: habitat degradation and ecological devastation, excessive use of natural resources (<xref ref-type="bibr" rid="B87">Hens and Boon, 2003</xref>; <xref ref-type="bibr" rid="B70">Gebretsadik, 2016</xref>; <xref ref-type="bibr" rid="B19">Bar et al., 2023</xref>).</p>
<sec id="s3-12-1">
<title>3.12.1 Risks to the flora</title>
<p>Synthetic cosmetics pose several risks to flora, which refers to the plant life within a particular ecosystem (<xref ref-type="bibr" rid="B51">Elisha and Terry, 2021</xref>; <xref ref-type="bibr" rid="B60">Faccio, 2020</xref>). These risks primarily stem from the production, usage (<xref ref-type="bibr" rid="B133">Nduka and Kelle, 2018</xref>), and disposal of synthetic cosmetics, as well as the ingredients contained within them (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>; <xref ref-type="bibr" rid="B103">Lafforgue and Lafforgue, 2021</xref>).</p>
<p>Chemical Pollution: Synthetic cosmetics often contain various chemicals, such as parabens, phthalates, sulfates, and synthetic fragrances (Washington State Department of Ecology (Ecology), 2023). When these products are washed off during bathing or disposed of improperly, these chemicals can find their way into water bodies through sewage systems (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>). Once in the water, they can negatively impact aquatic flora by disrupting their growth, reproduction, and overall health (<xref ref-type="bibr" rid="B218">Gonsioroski et al., 2020</xref>; <xref ref-type="bibr" rid="B92">Issac and Kandasubramanian, 2021</xref>).</p>
<p>Soil Contamination: Improper disposal of synthetic cosmetics, such as dumping unused products or washing them off directly onto soil, can lead to soil contamination (<xref ref-type="bibr" rid="B219">Bowen, 1975</xref>). Chemicals from these cosmetics can leach into the soil, affecting the microbial communities essential for nutrient cycling and plant growth (<xref ref-type="bibr" rid="B210">Yadav, 2023</xref>). Contaminated soil may also hinder the germination of seeds and the growth of plant roots (<xref ref-type="bibr" rid="B147">Paulsen, 2015</xref>; Yu et al., 2022).</p>
<p>Habitat Destruction: The production of synthetic cosmetics often involves the extraction of natural resources, such as minerals and petroleum (<xref ref-type="bibr" rid="B118">Martins and Marto, 2023</xref>). This extraction process can lead to habitat destruction, particularly in biodiverse areas rich in flora. Deforestation, soil erosion, and habitat fragmentation are some of the consequences that can directly harm plant species and disrupt ecosystems (<xref ref-type="bibr" rid="B57">European Business and Biodiversity Campaign, 2010</xref>).</p>
<p>Invasive Species Introduction: Some synthetic cosmetic ingredients, especially microplastics and non-biodegradable substances, can inadvertently introduce invasive species into natural habitats (<xref ref-type="bibr" rid="B104">Lauren, 2019</xref>; <xref ref-type="bibr" rid="B143">Osman et al., 2023</xref>; <xref ref-type="bibr" rid="B216">Ziani et al., 2023</xref>). For example, microbeads used in exfoliating scrubs can enter water bodies and act as vectors for the spread of invasive plant species, disrupting native flora and outcompeting indigenous plants.</p>
<p>Air Pollution: The production and transportation of synthetic cosmetics contribute to air pollution through the release of greenhouse gases and other pollutants. Air pollution can negatively impact plant health by interfering with photosynthesis, damaging leaf surfaces, and altering soil pH levels through acid rain deposition, ultimately affecting the composition and distribution of flora within ecosystems (<xref ref-type="bibr" rid="B220">Florentina and Io, 2011</xref>; <xref ref-type="bibr" rid="B221">Acwin Dwijendra et al., 2023</xref>).</p>
<p>Different parts of the plant (<xref ref-type="table" rid="T4">Table 4</xref>) can provide ingredients for cosmetic and personal care products (<xref ref-type="bibr" rid="B60">Faccio, 2020</xref>).</p>
<table-wrap id="T4" position="float">
<label>TABLE 4</label>
<caption>
<p>Different parts of plants used as cosmetic ingredients.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Part of plant</th>
<th align="left">Specific plant species</th>
<th align="left">Compound to be extracted</th>
<th align="left">Cosmetic application</th>
<th align="left">Impact on plant species</th>
<th align="left">References</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">Bark</td>
<td align="left">
<italic>Cinnamomum verum</italic>
</td>
<td align="left">Cinnamaldehyde, Eugenol, Cinnamic Acid, Coumarin, Polyphenols, Tannins, Volatile Oils</td>
<td align="left">antimicrobial protection, antioxidant support, anti-inflammatory effects, and skin brightening</td>
<td align="left">The loss of bark from a plant can expose the inner tissues to environmental stressors, pathogens, and physical damage. This can disrupt the plant&#x2019;s vascular system, leading to decreased nutrient and water transport, and ultimately affecting its overall health and survival</td>
<td align="left">
<xref ref-type="bibr" rid="B88">Hwang et al. (2014),</xref> <xref ref-type="bibr" rid="B135">Nestby (2020),</xref> <xref ref-type="bibr" rid="B102">Kowalczyk et al. (2024)</xref>
</td>
</tr>
<tr>
<td align="left">Flowers</td>
<td align="left">
<italic>Dendrobium</italic>
</td>
<td align="left">Pelargonidin, sinapic, ferulic acids</td>
<td align="left">Skin firming and whitening</td>
<td align="left">Flowers are crucial for plant reproduction through pollination. The loss of flowers can prevent the plant from producing seeds and fruits, impacting its ability to reproduce and potentially reducing genetic diversity within the population. Additionally, flowers often attract pollinators essential for the reproduction of other plant species in the ecosystem</td>
<td align="left">
<xref ref-type="bibr" rid="B201">Wang et al. (2019)</xref>; <xref ref-type="bibr" rid="B60">Faccio (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Fruit</td>
<td align="left">
<italic>Castanea sativa</italic>
</td>
<td align="left">Ellagic acid/polyphenolic</td>
<td align="left">Anti-aging formulations, Skin brightening products, Anti-inflammatory creams, Moisturizers and emollients, Sun care products, and Hair care products</td>
<td align="left">Fruits contain seeds, which are essential for the propagation and dispersal of many plant species. The loss of fruits can hinder the plant&#x2019;s ability to reproduce and spread its genetic material to new areas. It can also impact the plant&#x2019;s interactions with seed-dispersing animals, potentially affecting the plant&#x2019;s survival and distribution</td>
<td align="left">
<xref ref-type="bibr" rid="B150">Pinto et al., (2017)</xref>, <xref ref-type="bibr" rid="B151">Pinto et al. (2021)</xref>
</td>
</tr>
<tr>
<td align="left">Leaves</td>
<td align="left">
<italic>Azadirachta indica</italic>
</td>
<td align="left">Nimbidin, Nimbin, Quercetin, Nimbolinin, Nimbinin</td>
<td align="left">Anti-inflammatory, Anti-bacterial, Skin-soothing, Antioxidant, Antifungal</td>
<td align="left">Leaves are crucial for photosynthesis, the process by which plants convert sunlight into energy. The loss of leaves can significantly reduce a plant&#x2019;s ability to produce food and energy, leading to stunted growth, weakened defenses against pests and diseases, and, in severe cases, plant death</td>
<td align="left">
<xref ref-type="bibr" rid="B197">Vanderplanck et al. (2020),</xref> <xref ref-type="bibr" rid="B81">Haji et al. (2023),</xref> <xref ref-type="bibr" rid="B164">Rodrigues et al. (2023)</xref>
</td>
</tr>
<tr>
<td align="left">Nuts</td>
<td align="left">
<italic>Butyrospermum parkii</italic>
</td>
<td align="left">Triglycerides, Oleic Acid, Stearic Acid, Linoleic Acid, Tocopherols (Vitamin E), Phytosterols, Allantoin</td>
<td align="left">Moisturizers, body butters, lip balms, hair conditioners, and massage creams, to provide hydration, nourishment, and protection to the skin and hair</td>
<td align="left">Nuts are seeds enclosed in a hard shell, often dispersed by animals. The loss of nuts can prevent the plant from reproducing and spreading its seeds to new locations. Additionally, nuts may serve as a food source for wildlife, and their loss can disrupt ecological relationships within the ecosystem</td>
<td align="left">
<xref ref-type="bibr" rid="B54">Esposito et al. (2017),</xref> <xref ref-type="bibr" rid="B86">Helmstetter et al. (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Pollen</td>
<td align="left">
<italic>Carthamus tinctorius</italic>
</td>
<td align="left">Linoleic acid</td>
<td align="left">Antioxidants</td>
<td align="left">Pollen is essential for plant reproduction through pollination. The loss of pollen can prevent fertilization and seed production, ultimately impacting the plant&#x2019;s ability to reproduce and maintain its population size</td>
<td align="left">
<xref ref-type="bibr" rid="B37">Chamer et al. (2015),</xref> <xref ref-type="bibr" rid="B23">Bergman and Kandel (2017),</xref> <xref ref-type="bibr" rid="B60">Faccio (2020)</xref>
</td>
</tr>
<tr>
<td align="left">Roots</td>
<td align="left">
<italic>Glycyrrhiza glabra</italic>
</td>
<td align="left">Glycyrrhizin or licorice</td>
<td align="left">anti-inflammatory, antioxidant, and skin-soothing</td>
<td align="left">Roots anchor the plant in the soil and absorb water and nutrients from the environment. The loss of roots can destabilize the plant, making it more susceptible to wind, water erosion, and physical damage. It can also compromise the plant&#x2019;s ability to access essential resources, leading to decreased growth and survival</td>
<td align="left">
<xref ref-type="bibr" rid="B205">Weryszko-Chmielewska et al. (2012),</xref> <xref ref-type="bibr" rid="B36">Cerulli et al. (2022)</xref>
</td>
</tr>
<tr>
<td align="left">Seeds</td>
<td align="left">
<italic>Simmondsia chinensis</italic>
</td>
<td align="left">jojoba oil (wax esters), vitamin E, phytosterols, omega-9 fatty acids, and polyphenols</td>
<td align="left">skin and hair care</td>
<td align="left">Seeds are crucial for the propagation and dispersal of many plant species. The loss of seeds can prevent the plant from reproducing and establishing new individuals in suitable habitats, ultimately affecting its population dynamics and long-term survival</td>
<td align="left">
<xref ref-type="bibr" rid="B169">Sandha and Swami (2009),</xref> <xref ref-type="bibr" rid="B205">Weryszko-Chmielewska et al. (2012),</xref> <xref ref-type="bibr" rid="B91">Inoti. (2017)</xref>; <xref ref-type="bibr" rid="B60">Faccio (2020),</xref> <xref ref-type="bibr" rid="B66">Gad et al. (2021)</xref>
</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>It has been documented that components taken from plant parts such as bark, flowers, fruit, leaves, nuts, petals, pollen, seeds, roots, sprouts, stems, and other types of plant parts are used to create cosmetic products (<xref ref-type="bibr" rid="B78">Gupta and Prakash, 2013</xref>). This may result in plant species disappearing from the environment. As a result, plant biodiversity declines. This contributes to additional global warming through deforestation, which once more has a detrimental impact on human welfare (<xref ref-type="bibr" rid="B167">Sagbo, 2021</xref>; <xref ref-type="bibr" rid="B128">Nadeeshani Dilhara Gamage et al., 2022</xref>).</p>
<p>The loss of different plant parts used as ingredients in cosmetic formulations can have significant ecological and physiological consequences for the plant species involved, potentially affecting their growth, reproduction, and survival in their natural habitats.</p>
</sec>
<sec id="s3-12-2">
<title>3.12.2 Risk on fauna</title>
<p>Without appropriate action, the loss of biodiversity will keep accelerating, with unexpected impacts on the economy and society (<xref ref-type="bibr" rid="B184">Spangenberg et al., 2012</xref>). The following elements are the main causes of biodiversity loss on a global scale: habitat degradation and ecological devastation, excessive use of natural resources (<xref ref-type="bibr" rid="B184">Spangenberg et al., 2012</xref>; <xref ref-type="bibr" rid="B222">David Elisha, 2021</xref>; <xref ref-type="bibr" rid="B82">Hatipoglu, 2023</xref>).</p>
<p>Most often, factory farms serve as the primary locations where pigs are slaughtered for their meat, and where portions of their bodies are processed to produce the cosmetic ingredient &#x201c;glycerine&#x201d; (<xref ref-type="bibr" rid="B1">Abattoir, 2015</xref>; <xref ref-type="bibr" rid="B131">National Pork Board, 2009</xref>). For instance, factory farms seriously harm the ecology (<xref ref-type="bibr" rid="B12">Anomaly, 2015</xref>). Due to the high concentration of phosphorus and nitrogen in factory-farmed pigs&#x2019; feces, when it contaminates areas outside the farm, it may cause a great deal of harm (<xref ref-type="bibr" rid="B41">Chemiczne and Wody, 2012</xref>; <xref ref-type="bibr" rid="B64">Fiut and Urbaniak, 2016</xref>).</p>
<p>Water gets excessively enriched in minerals and nutrients due to eutrophication, which is caused by run-off pollution from waste pits at factory farms. As a result, there is an excessive development of algae, which frequently causes the water&#x2019;s oxygen levels to drop. Fish and other aquatic plant and animal life are subsequently killed as a result. &#x2018;Dead zones&#x2019; are places where this happens (<xref ref-type="bibr" rid="B211">Yang et al., 2008</xref>).</p>
<p>In addition to being exploited and slaughtered for their meat, skin, and milk, cattle are also used to produce tallow and other cosmetic elements from their carcasses. Because so many cattle are produced for these purposes and because cattle emit such large amounts of greenhouse gases, these businesses are always bad for the environment (<xref ref-type="bibr" rid="B48">Durrans, 2013</xref>).</p>
<p>Every year, many millions of fish are murdered for food, oils, and substances like guanine. The effects on the ecology and, naturally, the fish, who suffer and perish, are very harmful (<xref ref-type="bibr" rid="B100">Kibria, 2024</xref>).</p>
<p>Oceans encompass 70% of the planet (<xref ref-type="bibr" rid="B202">Wang, 2021</xref>). The entire ocean ecology may collapse if we do end up with fishless or almost fishless oceans in the future, as is anticipated (<xref ref-type="bibr" rid="B48">Durrans, 2013</xref>). Species that depend on fish for sustenance would become extinct if humans wiped them off. Algae, kelp, plankton, krill, and worms would all suffer greatly without the symbiosis that all these species form in nature. The effects on the environment are mind-boggling (<xref ref-type="bibr" rid="B24">Bert, 2016</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s4">
<title>4 Challenges in managing cosmetic ingredients</title>
<p>Managing cosmetic ingredients poses several challenges (<xref ref-type="bibr" rid="B156">Raj and Chandrul, 2016</xref>), including:<list list-type="simple">
<list-item>
<p>1. Regulatory Complexity: The regulation of cosmetic ingredients varies greatly between regions and countries, making it challenging for companies to comply with different standards and requirements (<xref ref-type="bibr" rid="B125">Mohd Riyaz Beg, 2016</xref>; <xref ref-type="bibr" rid="B156">Raj and Chandrul, 2016</xref>; <xref ref-type="bibr" rid="B181">Singh et al., 2018</xref>; <xref ref-type="bibr" rid="B62">Ferreira et al., 2022</xref>; <xref ref-type="bibr" rid="B2">Abed et al., 2024</xref>). Harmonizing regulations globally can be difficult due to differing priorities, cultural attitudes, and scientific interpretations.</p>
</list-item>
<list-item>
<p>2. Ingredient Transparency: Lack of transparency regarding the ingredients used in cosmetic products can make it difficult for consumers to make informed choices (<xref ref-type="bibr" rid="B25">Bibby, 2018</xref>; <xref ref-type="bibr" rid="B186">Standard, 2020</xref>; <xref ref-type="bibr" rid="B170">Santoro, 2022</xref>). Some ingredients may be listed under generic terms or trade names, obscuring their true nature and potential risks (<xref ref-type="bibr" rid="B103">Lafforgue and Lafforgue, 2021</xref>).</p>
</list-item>
<list-item>
<p>3. Data Gaps in Safety Information: Many cosmetic ingredients lack comprehensive safety data, especially concerning long-term exposure and potential interactions with other chemicals (<xref ref-type="bibr" rid="B10">Amasa et al., 2012</xref>; <xref ref-type="bibr" rid="B187">Steiling, 2016</xref>; <xref ref-type="bibr" rid="B145">Panico et al., 2019</xref>; <xref ref-type="bibr" rid="B174">Scientific Committee on Consumer Safety, 2021</xref>). This makes it challenging to assess their environmental and health impacts accurately.</p>
</list-item>
<list-item>
<p>4. Emerging Contaminants: New cosmetic ingredients are continually being developed, and their environmental fate and toxicity may not be fully understood (<xref ref-type="bibr" rid="B96">Juliano and Magrini, 2017</xref>). These emerging contaminants can pose challenges for monitoring and management efforts.</p>
</list-item>
<list-item>
<p>5. Microplastics and Nanoparticles: Microplastics and nanoparticles are commonly used in cosmetics for various purposes, such as exfoliation and UV protection (<xref ref-type="bibr" rid="B106">Leslie, 2014</xref>; <xref ref-type="bibr" rid="B79">Gupta et al., 2022</xref>; <xref ref-type="bibr" rid="B216">Ziani et al., 2023</xref>). However, their small size makes them difficult to remove during wastewater treatment, leading to their accumulation in the environment and potential ecological harm.</p>
</list-item>
<list-item>
<p>6. Sustainable Sourcing: Many cosmetic ingredients are derived from natural resources, such as plants and minerals (<xref ref-type="bibr" rid="B120">McMullen and Dell&#x2019;Acqua, 2023</xref>). Unsustainable sourcing practices can lead to deforestation, habitat destruction, and loss of biodiversity, posing challenges for both environmental conservation and the long-term availability of these ingredients.</p>
</list-item>
<list-item>
<p>7. Consumer Behavior and Awareness: Despite increasing interest in sustainability and environmental issues, consumer behavior and awareness regarding the environmental impacts of cosmetics may still be limited (<xref ref-type="bibr" rid="B163">Rocca et al., 2022</xref>; <xref ref-type="bibr" rid="B118">Martins and Marto, 2023</xref>). Educating consumers and encouraging them to make more sustainable choices can be challenging.</p>
</list-item>
</list>
</p>
<p>Addressing these challenges requires collaboration among governments, industry stakeholders, scientific experts, and consumers to develop robust regulatory frameworks, improve ingredient transparency, enhance safety assessment methodologies, promote sustainable sourcing practices, and raise awareness about the environmental impacts of cosmetics (<xref ref-type="bibr" rid="B225">Iswahyudi et al., 2024</xref>).</p>
</sec>
<sec id="s5">
<title>5 Certifications</title>
<p>Certification in the cosmetic industry serves several purposes, primarily to assure consumers that products meet certain standards of safety, quality, and environmental responsibility. However, the necessity and effectiveness of certification in this industry are subjects of ongoing debate, particularly in light of the &#x201c;greenwashing&#x201d; phenomenon.</p>
<p>Greenwashing refers to the practice of companies making exaggerated or misleading claims about the environmental or ethical benefits of their products or practices (<xref ref-type="bibr" rid="B13">Aparna and Murugan, 2024</xref>). In the cosmetics industry, this often manifests as brands labeling their products as &#x201c;natural,&#x201d; &#x201c;organic,&#x201d; or &#x201c;eco-friendly&#x201d; without sufficient evidence to support these claims. Greenwashing can mislead consumers who are seeking genuinely sustainable or environmentally friendly options, leading them to choose products that may not align with their values (<xref ref-type="bibr" rid="B116">Lopes et al., 2023</xref>).</p>
<p>Several factors contribute to the prevalence of greenwashing in the cosmetics industry:<list list-type="simple">
<list-item>
<p>1. Lack of Regulation: The cosmetics industry is not as heavily regulated as other sectors, such as pharmaceuticals or food. This lack of oversight allows companies to make unsubstantiated claims without facing significant consequences (<xref ref-type="bibr" rid="B9">Alexa, 2021</xref>).</p>
</list-item>
<list-item>
<p>2. Complexity of Ingredients: Consumers may have difficulty understanding ingredient lists and deciphering which products are truly environmentally friendly or sustainable (<xref ref-type="bibr" rid="B101">Komis, 2022</xref>). This confusion can make them more susceptible to greenwashing tactics.</p>
</list-item>
<list-item>
<p>3. Market Demand: There is growing consumer demand for natural and eco-friendly products (<xref ref-type="bibr" rid="B22">Baviskar et al., 2024</xref>), leading companies to capitalize on this trend by marketing their products as such, even if their claims are not entirely accurate.</p>
</list-item>
<list-item>
<p>4. Competitive Pressure: Companies may feel pressured to engage in greenwashing to remain competitive in the market, especially if they perceive that consumers are increasingly prioritizing sustainability (<xref ref-type="bibr" rid="B116">Lopes et al., 2023</xref>; <xref ref-type="bibr" rid="B155">Quicanga, 2023</xref>).</p>
</list-item>
</list>
</p>
<p>To combat greenwashing and provide consumers with more reliable information, various certification schemes have been developed in the cosmetics industry. These certifications typically involve rigorous testing and evaluation of products to ensure they meet specific standards for ingredients, manufacturing processes, and environmental impact (<xref ref-type="bibr" rid="B194">U.S. FDA, 2021</xref>). Some of the most widely recognized certifications include:<list list-type="simple">
<list-item>
<p>1. USDA Organic: This certification verifies that products meet the United States Department of Agriculture&#x2019;s standards for organic production, including the use of organic ingredients and environmentally friendly practices (<xref ref-type="bibr" rid="B192">U.S. Department of Agriculture, 2011</xref>).</p>
</list-item>
<list-item>
<p>2. Ecocert: Ecocert is an independent certification body that verifies the natural and organic content of cosmetics and ensures they meet certain environmental and ethical standards (<xref ref-type="bibr" rid="B49">ECOCERT Greenlife, 2022</xref>).</p>
</list-item>
<list-item>
<p>3. COSMOS: COSMOS (Cosmetic Organic and Natural Standard) is a Europe-wide standard for organic and natural cosmetics. It sets criteria for ingredients, manufacturing processes, packaging, and labeling to ensure products are environmentally friendly and sustainable (<xref ref-type="bibr" rid="B45">COSMOS, 2023</xref>).</p>
</list-item>
<list-item>
<p>4. Leaping Bunny: The Leaping Bunny certification is awarded to companies that have demonstrated their products are cruelty-free, meaning they were not tested on animals at any stage of development (<xref ref-type="bibr" rid="B77">Guide, 2020</xref>).</p>
</list-item>
</list>
</p>
<p>These certifications were chosen for their widespread recognition and credibility within the cosmetics industry. While there are other certifications available, these four are among the most well-established and trusted by consumers seeking genuinely sustainable and ethically produced cosmetics. However, consumers need to remain vigilant and critically evaluate the claims made by brands, as greenwashing tactics continue to evolve and adapt. Additionally, efforts to improve regulation and transparency in the industry can help reduce the prevalence of greenwashing and ensure consumers can make informed choices about the products they purchase.</p>
</sec>
<sec sec-type="conclusion" id="s6">
<title>6 Conclusion</title>
<p>Cosmetic items have a big impact on the environment and human health. Because some items contain chemical substances, there is a chance that they will cause health problems like allergies, sensitivities, and skin irritation. Certain ingredients in cosmetics, such as phthalates and parabens, have been connected to hormone disruption, which may affect the development and health of the reproductive system. Furthermore, several chemicals, including coal tar compounds and formaldehyde, have been identified as carcinogenic, which raises questions about potential long-term health effects, such as an elevated risk of cancer.</p>
<p>Regarding the environment, throughout their existence, cosmetic products have contributed to several types of pollution. The manufacturing process has the potential to emit contaminants into the air and water during production, which could worsen the local community&#x2019;s public health issues and cause environmental damage. In addition, the discarding of cosmetics especially those that include microplastics may contaminate ecosystems and waterways. Because microplastics can be consumed and cause harm at different stages of the food chain, the buildup of tiny particles in the environment is a concern to marine life and wildlife. Furthermore, the production, packing, and shipping of cosmetics all have a carbon footprint that contributes to climate change and exacerbates environmental problems worldwide. All things considered, tackling the effects of cosmetics on the environment and human health requires extensive initiatives meant to advance safer ingredients, environmentally friendly manufacturing processes, and conscientious consumer behavior.</p>
</sec>
</body>
<back>
<sec id="s7">
<title>Author contributions</title>
<p>YW: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Software, Supervision, Writing&#x2013;original draft, Writing&#x2013;review and editing.</p>
</sec>
<sec sec-type="funding-information" id="s8">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<sec sec-type="COI-statement" id="s9">
<title>Conflict of interest</title>
<p>The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s10">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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