<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3-mathml3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="retraction" dtd-version="1.3" xml:lang="EN">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Endocrinol.</journal-id>
<journal-title-group>
<journal-title>Frontiers in Endocrinology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Endocrinol.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">1664-2392</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fendo.2025.1751575</article-id>
<article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Retraction</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Retraction: LRP6 knockdown ameliorates insulin resistance via modulation of autophagy by regulating GSK3&#x3b2; signaling in human L02 hepatocytes</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><collab>Frontiers Editorial Office</collab>
<xref ref-type="corresp" rid="c001"><sup>*</sup></xref>
</contrib>
</contrib-group>
<author-notes>
<corresp id="c001"><label>*</label>Correspondence: Frontiers Editorial Office, <email xlink:href="mailto:research.integrity@frontiersin.org">research.integrity@frontiersin.org</email></corresp>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-11-27">
<day>27</day>
<month>11</month>
<year>2025</year>
</pub-date>
<pub-date publication-format="electronic" date-type="collection">
<year>2025</year>
</pub-date>
<volume>16</volume>
<elocation-id>1751575</elocation-id>
<history>
<date date-type="received">
<day>21</day>
<month>11</month>
<year>2025</year>
</date>
<date date-type="accepted">
<day>21</day>
<month>11</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2025 Frontiers Editorial Office.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Frontiers Editorial Office</copyright-holder>
<license>
<ali:license_ref start_date="2025-11-28">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<related-article id="RA1" related-article-type="retracted-article" ext-link-type="doi" xlink:href="10.3389/fendo.2019.00073" journal-id="Front Endocrinol" journal-id-type="nlm-ta">A Retraction of the Original Research Article 
<article-title>LRP6 knockdown ameliorates insulin resistance via modulation of autophagy by regulating GSK3&#x3b2; signaling in human LO2 hepatocytes</article-title> By Li L, Xue J, Wan J, Zhou Q, Wang S, Zhou Y, Zhao H and Wang X (2019) <italic>Front. Endocrinol.</italic> 10:73. doi:&#xa0;<object-id>10.3389/fendo.2019.00073</object-id>
</related-article>
<counts>
<fig-count count="0"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="0"/>
<page-count count="1"/>
<word-count count="94"/>
</counts>
<custom-meta-group>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Cellular Endocrinology</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<p>The journal retracts the February 19 2019 article cited above.</p>
<p>Following publication, concerns were raised regarding the integrity of the images in the published figures. The authors failed to provide a satisfactory explanation during the investigation, which was conducted in accordance with Frontiers&#x2019; policies.</p>
<p>This retraction was approved by the Chief Executive Editor of Frontiers. The authors received a communication regarding the retraction and had a chance to respond. This communication has been recorded by the publisher.</p>
<p>Frontiers would like to thank the users on PubPeer for bringing the published article to our attention.</p>
</body>
<back>
<fn-group>
<fn id="n1" fn-type="custom" custom-type="approved-by">
<p>Approved by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/111428">Frontiers Editorial Office</ext-link>, Frontiers Media SA, Switzerland</p></fn>
</fn-group>
</back>
</article>