AUTHOR=Li Pengcheng , Cai Jirui , Yuan Shuaifang , Li Yapeng , Shi Huiting , Liang Cui , He Bing , Xie Qiaotao , Lei Baocang , Bai Jing , Wang Nan , Liu Dongliang , Wang Qichao , Xiong Jianwei , Wang Jin , Wang Haoran 

TITLE=The relationship between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular high risk: a cross-sectional investigation

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1688624

DOI=10.3389/fendo.2025.1688624

ISSN=1664-2392

ABSTRACT=AimsThe triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio reflects the balance between atherogenic and anti-atherogenic lipid fractions. The study aims to investigate the utility of the TG/HDL-C ratio in identifying high-risk groups for cardiovascular disease (CVD) within the general population.MethodsThe current study was a branch of the ChinaHEART cohort in middle China that involved a total of 6,593 community-dwelling adults. We examine the association between TG/HDL-C and CVD high-risk in a cross-sectional investigation.ResultsResults from restricted cubic spline and ROC analyses revealed a significant relationship between higher TG/HDL-C levels and increased odds of CVD high-risk, with the ratio exhibiting good discriminatory power (AUC = 0.820 in the fully adjusted model). Logistic regression further supported this association, indicating a 1.21-fold rise in the odds of high risk for each unit increase in TG/HDL-C.ConclusionsThe TG/HDL ratio shows promise for CVD risk assessment. Incorporating the TG/HDL ratio into risk assessment models may provide supplementary information to healthcare professionals for risk stratification.