Front. Endocrinol. Frontiers in Endocrinology Front. Endocrinol. 1664-2392 Frontiers Media S.A. 10.3389/fendo.2025.1633411 Endocrinology Systematic Review Pheochromocytoma metastasis to the central nervous system: a case report and systematic review Fercho Justyna Małgorzata 1 2 3 4 * † Chasles Oskar G. 4 † Chamier-Gliszczyński Jakub 4 Płaza Dominik Ryszard 4 Jabłoński Bogdan 4 Kokot Klaudia 4 Mielczarek Maciej 5 Małłek-Grabowska Małgorzata 6 7 Szypenbejl Jacek 2 4 Szkudlarek Adrian 1 Szmuda Tomasz 8 Siemiński Mariusz 2 4 Furtak Jacek 1 7 1 Neurosurgery Department, 10th Military Research Hospital and PolyClinic SPZOZ, Bydgoszcz, Poland 2 Department of Emergency Medicine, Medical University of Gdańsk, Gdańsk, Poland 3 Lung Transplant Unit, Cardiac Surgery Department, Medical University of Gdańsk, Gdańsk, Poland 4 Scientific Circle of Neurotraumatology, Department of Emergency Medicine, Medical University of Gdańsk, Gdańsk, Poland 5 Neurosurgery Department, Stanisław Staszic Specialist Hospital, Piła, Poland 6 Department of Anesthesiology and Intensive Therapy, 10th Military Research Hospital and Polyclinic SPZOZ, Bydgoszcz, Poland 7 Faculty of Medicine, Bydgoszcz University of Science and Technology, Bydgoszcz, Poland 8 Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland

Edited by: Sergei Tevosian, University of Florida, United States

Reviewed by: Vitaly Kantorovich, Hartford HealthCare, United States

Federico Polverino, University of Naples Federico II, Italy

*Correspondence: Justyna Małgorzata Fercho, jfercho@gumed.edu.pl

†These authors share first authorship

 25 08 2025 10 09 2025 2025 16 1633411 22 05 2025 28 07 2025 Copyright © 2025 Fercho, Chasles, Chamier-Gliszczyński, Płaza, Jabłoński, Kokot, Mielczarek, Małłek-Grabowska, Szypenbejl, Szkudlarek, Szmuda, Siemiński and Furtak. 2025 Fercho, Chasles, Chamier-Gliszczyński, Płaza, Jabłoński, Kokot, Mielczarek, Małłek-Grabowska, Szypenbejl, Szkudlarek, Szmuda, Siemiński and Furtak

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 Background

Pheochromocytoma (PCC) is a rare neuroendocrine tumor, with 10–15% of cases showing malignant behavior defined by metastatic spread, including exceptionally rare central nervous system (CNS) involvement. Brain metastases present unique diagnostic and therapeutic challenges due to their potential to impair neurological function. This study reports a case of malignant PCC (mPCC) with CNS metastases and a systematic review to clarify the clinical patterns, management strategies, and prognostic factors.

 Methods

We describe the surgically managed case of a 41-year-old man with right frontoparietal brain metastasis. A systematic review, adhering to the PRISMA 2020 guidelines, searched PubMed, Scopus, and Web of Science for peer-reviewed studies on mPCC with brain or spinal metastases confirmed by radiology or histopathology. Data on demographics, symptoms, imaging, treatments, and outcomes were extracted and descriptively analyzed using Python-generated graphics.

 Results

This review identified 18 cranial (1948–2022) and 60 spinal (1977–2024) metastasis cases from 53 studies. Cranial metastases were present at a mean age of 46.6 years (SD 14.1), commonly with headaches (44.4%) and neurological deficits, such as weakness, presented in our case, with 72.2% surgically treated. Spinal metastases occurred at a mean age of 44.5 years (SD, 16.0), often with hypertension (51.7%) or pain, with a mean of 1.7 lesions (SD 1.5). The patient achieved short-term symptom relief post-resection, but incomplete follow-up (33.3% cranial) and reporting gaps (63.3% spinal laterality) limited the prognostic insights. MRI and PET improved the diagnostic accuracy over historical non-contrast CT use (41.7% spinal cases).

 Interpretation

CNS mPCC metastases are exceedingly rare with distinct neurological (cranial) and structural (spinal) presentations. Advanced imaging, particularly magnetic resonance imaging (MRI) and positron emission tomography (PET), is critical for accurate diagnosis and surgical planning. Sparse data underscores the need for registries and prospective studies to standardize care and improve outcomes.

 pheochromocytoma malignant pheochromocytoma spinal metastases cerebral metastases central nervous system section-in-acceptance Adrenal Endocrinology Introduction

Pheochromocytoma (PCC) is a rare neuroendocrine tumor arising from chromaffin cells, predominantly in the adrenal medulla, with an estimated incidence of 0.8 per 100,000 person-years (1). Alongside extra-adrenal paragangliomas, PCC forms a spectrum of catecholamine-secreting tumors that affect patients globally, with variations in prevalence across sporadic and hereditary contexts. Its pathophysiology centers on excessive catecholamine production, including epinephrine, norepinephrine, and dopamine, manifesting as paroxysmal hypertension, tachycardia, diaphoresis, and, in extreme cases, hypertensive crises that threaten cardiovascular stability (1). PCC occurs sporadically or within hereditary syndromes like von Hippel-Lindau disease (VHL), multiple endocrine neoplasia type 2 (MEN2), or neurofibromatosis type 1 (NF1), with mutations, particularly SDHB, increasing malignancy risk (2, 3).

Approximately 10–15% of PCCs are malignant, defined by metastatic spread, with a slight male predominance noted in some series (4). Common metastatic sites include the liver, lungs, and skeleton; however, central nervous system (CNS) involvement, encompassing brain and spinal metastases, is extraordinarily rare, with fewer than 100 cases reported over eight decades (5, 6). The scarcity of CNS metastases complicates diagnosis and management, as their neurological consequences (e.g., deficits and seizures) and structural impacts (e.g., spinal instability) require specialized intervention.

Diagnosis of malignant PCC (mPCC) integrates biochemical assays, imaging, and genetic profiling. Plasma-free metanephrines and urinary catecholamines offer high sensitivity, although false positives require careful interpretation (7, 8). Imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and 123I-metaiodobenzylguanidine (MIBG) scintigraphy localize tumors, with MRI excelling for CNS lesions and positron emission tomography (PET) aiding systemic staging (9). Genetic testing identifies high-risk mutations; however, global disparities limit access (2). Management hinges on preoperative alpha- and beta-adrenergic blockade to stabilize hemodynamics, followed by surgery for resectable metastases. CNS cases require additional consideration, balancing neurological preservation and oncological control (5, 10).

This study presents a rare case of CNS mPCC cerebral metastasis, illustrating distinct clinical and therapeutic complexities. The patient signed an informed consent form, allowing the authors to publish the results. Through a systematic review, we synthesized global data to elucidate the demographics, diagnostics, treatments, and gaps, aiming to inform clinical practice and future research on this understudied malignancy.

 Case report Cerebral metastasis Patient background

A 41-year-old right-handed male was referred to the Neurosurgery Department for a right frontoparietal tumor identified by computed tomography (CT) at Głogów Hospital after two weeks of progressive left-sided weakness. His history included mPCC diagnosed post-laparoscopic adrenalectomy (September 2007) with open resection of a local recurrence (July 2008). Exploratory laparotomy (June 2015) revealed unresectable inferior vena cava invasion. He received stereotactic radiotherapy to the adrenal bed (30 Gy, May 2017), followed by 177Lu-DOTATATE for retroperitoneal lymph node metastases (first dose, November 2022), and sunitinib (initiated on March 9, 2023), achieving a partial response. The comorbidities included resistant hypertension, likely catecholamine-driven, and suspected autoimmune thyroiditis. To date, no allergies have been reported. The patient was later referred to the Neurosurgery Department at the 10th Military Research Hospital and Polyclinic in Bydgoszcz, Poland, due to the need for further treatment requiring greater neurosurgical capabilities. Enabling this treatment necessitated the patient’s transport across two voivodeships.

 Clinical findings

On admission, the patient was alert and oriented, with a Glasgow Coma Scale (GCS) score of 15 and Karnofsky Performance Status (KPS) score of 80, reflecting preserved function despite systemic disease. Neurological examination revealed no motor deficits, although prior weakness prompted imaging.

 Preoperative diagnosis

Suspected mPCC metastasis to the right frontoparietal region based on CT and oncological history.

 Surgical management

On August 1, 2024, neuronavigation-assisted craniectomy was performed under general anesthesia. The patient was supine, and the head was secured using the Z-touch neuronavigation system to map the tumor. A parietal incision enabled a skin-fascia flap and craniectomy near the sagittal sinus, which was controlled with hemostatic sutures. Dural incision revealed no initial motor cortex response upon stimulation. A 5-mm cortical incision exposed a grayish-cream, moderately vascular tumor resected via a cavitron ultrasonic surgical aspirator (CUSA). A second brownish, highly vascular segment extended into the right lateral ventricle, requiring meticulous resection. Fluorescent residual tissue (pink under UV light) was cleared. Stimulation (5 mA) at the anteromedial margin elicited left extremity responses, indicating motor cortex proximity, prompting careful closure. Hemostasis was performed using Surgicel; the dura was sealed with sutures and TachoSil, and the bone flap was secured with CranioFix, followed by cranioplasty with bone cement. The wound was closed in layers and the patient was transferred to the ICU. Preoperative alpha- and beta-blockers ensured hemodynamic stability with no intraoperative complications.

 Histopathology

Two samples confirmed metastatic mPCC, showing a nested (zellballen) architecture typical of pheochromocytoma. Immunohistochemistry revealed the following findings:

Positive: Vimentin (++, strong), CD10 (+, weak), Chromogranin A (++, strong), and synaptophysin (++, strong).

Negative: GATA3, Melan A, CAM 5.2, TTF1, CK-PAN, and S-100.

Strong positivity (++) for Chromogranin A and Synaptophysin, with weaker CD10, confirmed a neuroendocrine origin, ruling out carcinoma or melanoma. The absence of GATA3 and TTF1 excluded thyroid or lung primaries, aligning with the patient’s history of mPCC.

 Postoperative imaging

Non-contrast CT (August 2, 2024) showed a 48 × 23 mm fluid-filled resection cavity, consistent with postoperative changes, with successful cranioplasty. Brain parenchyma, ventricles, and midline were unremarkable ( Figure 1 ).

(A) Preoperative T1-weighted MRI with contrast showing cranial metastasis of the pheochromocytoma. (B) Non-contrast CT scan performed on the first postoperative day, demonstrating postsurgical changes. (C) T1-weighted MRI with contrast at 3 months postoperatively, illustrating the postoperative outcomes. (D) Intraoperative photograph of resected pheochromocytoma metastasis. (E) Intraoperative photograph obtained during the resection of a cranial metastatic tumor.

MRI scans labeled A, B, and C show a brain tumor from different angles. D captures a surgical view of brain tissue. E shows excised tumor tissue in a blue tray. Postoperative diagnosis

Resected right frontoparietal mPCC metastasis with cranioplasty, histologically verified.

 Outcome

Short-term neurological preservation was achieved with no immediate deficits, although systemic disease indicated a guarded prognosis.

 Methodology Search strategy and protocol

This systematic review was conducted in accordance with PRISMA 2020 guidelines. A comprehensive search strategy was developed and implemented across three electronic databases, PubMed, Scopus, and Web of Science. The search utilized the following terms: (“pheochromocytoma”) AND ((“malignant”) OR (“metastasis”)) AND ((“brain” OR “cerebrum” OR “intracranial” OR “cranium” OR “skull”) OR (“spine” OR “vertebra”)). No date or language restrictions were applied, resulting in 1426 records from 1948 to 2024. After removing 187 duplicates and 140 results owing to insufficient metadata for screening, 1099 unique records were retained for screening ( Figure 2 ).

PRISMA Flowchart.

PRISMA 2020 flow diagram for systematic reviews. Identification phase shows 1,426 records from databases: PubMed (415), Scopus (809), Web of Science (202). Removed before screening: 187 duplicates, 140 with insufficient metadata. Screening phase: 1,099 records, 1,013 excluded by authors. Retrieval phase: 86 reports sought, 23 not retrieved, 63 assessed for eligibility. Excluded: 10 for insufficient data. Included: 53 studies (18 cranial, 35 spine). Selection criteria

The eligibility criteria were peer-reviewed case reports and case series documenting patients with primary adrenal pheochromocytoma (PCC) and metastatic lesions to the central nervous system or related bony structures (cranium or spine), who granted consent for publication to the authors of included studies. Metastatic disease requires confirmation via radiological (e.g., CT, MRI) or histopathological evidence. The exclusion criteria included studies with insufficient data (n = 10), studies unrelated to the specified anatomical regions, and studies with irretrievable full texts (n = 23). A two-stage screening process was conducted by four authors (OC, JG, DP, and BJ): initial title and abstract screening, followed by full-text analysis. Discrepancies during screening were resolved through consensus discussion or adjudication by senior authors (JF, MM, and TS). Manual screening was used exclusively, without artificial intelligence or automation tools, to ensure rigorous human oversight during the study selection.

 Statistical analysis

Fifty-three peer-reviewed studies, comprising 78 individual cases of metastatic adrenal PCC (18 cranial, 60 spinal), were included in this retrospective analysis. Extracted clinical data included patient factors (age at diagnosis, sex, genetic predisposition, von Hippel-Lindau disease, tumor laterality, number and location of metastases, admission symptoms, urinary metanephrine/normetanephrine levels, and immunohistochemical markers) and treatment factors (treatment method, follow-up duration, and outcomes). Descriptive statistics were calculated as follows: continuous data (e.g., age and number of metastases) were reported as means, standard deviations (SD), medians, and ranges; categorical data (e.g., genetic causes, imaging modalities) were expressed as proportions. Missing data (“not specified” [NS]) were noted as percentages where applicable. Data were tabulated and synthesized descriptively, providing extractable insights into the clinical course of the patients. No artificial intelligence methods were employed in the data extraction or analysis; all graphical presentations, including histograms, bar charts, and pie charts, were generated using Python with the matplotlib and seaborn libraries to ensure a clear and accurate representation of the findings.

 Results Cranial metastases

Eighteen studies (1948–2022) reported 18 cases (10 males [55.6%] and 8 females [44.4%]) ( Table 1 ). The mean age at PCC diagnosis was 35.0 years (SD 14.4, median 34, range 10–53); metastases occurred at 46.6 years (SD 14.1, median 48, range 23–73) ( Figure 3 ), with an 11.6-year latency. Genetic predisposition was 16.7% (n=3, no VHL). The tumors were unilateral (72.2%, n=13), bilateral (5.6%, n=1), or unspecified (22.2%, n=4) ( Figure 4 ). The metastases were solitary (n=10), dual (n=1), numerous (n=5), or unspecified (n=2). Symptoms included headache (44.4%, n=8), hypertension (27.8%, n=5), and sweating (5.6%, n=1). Treatments included resection (72.2%, n=13), radiotherapy (38.9%, n=7, including one MIBG, one stereotactic), or chemotherapy (11.1%, n=2); one case lacked data. Follow-up (12/18 cases, 33.3% missing) revealed 7 deaths, 1 relapse, and 4 no relapses. Immunohistochemistry revealed Chromogranin A (n=10), synaptophysin (n=7), and neuron-specific enolase (n=5).

summarizes the data from 18 studies (1948–2022, 18 patients) on cranial pheochromocytoma metastases, including demographics, symptoms, imaging, treatment, immunohistochemistry, and outcomes.

Reference Sex Age at initial diagnosis Laterality Age at resection/adrenalectomy Age at metastasis diagnosis Location of cranial metastasis Symptoms Treatment Immunohistochemistry results
(11) F NS Bilateral No adrenalectomy 51 Peduncles, cerebellum, pons, cerebrum Headaches, syncope, poor memory, drowsiness, convulsions Right subtemporal decompression NS
(12) M NS Unilateral NS 61 NS Hypertension, sweating, headaches, convulsions, palpitations None NS
(13) M NS NS NS 47 Cerebrum, cerebellum Cognitive deterioration None NS
(14) F 43 Unilateral NS 43 Prominent extradural scalp mass in parietal region Painless scalp mass, low back pain Resection chromogranin, neuron-specific enolase
(15) F NS Unilateral 41 49 NS Hypertension NS NS
(16) F NS NS NS 31 Right frontal lesion Partial motor seizure Resection Neuron-specific enolase, S100protein and chromogranin, negative anti-calcitonin
(17) M 37 Unilateral 37 47 Right frontotemporal Hypertension Resection, MIBG therapy Chromogranin, negative progesterone receptors and epithelialmembrane antigen
(18) F NS NS 23 46 Right temporoparietal extra-axial lesion with inner table skull infiltration Hypertension, headaches, vomiting Resection Neuron-specific enolase,chromogranin A, synaptophysin
(19) F NS Unilateral 59 60 Left frontal and parietal lobe Hypertension Resection, radiotherapy NS
(20) M 49 Unilateral 49 54 Left occipital lobe Headaches, cognitive decline, visual loss, shortness of breath Resection, pre-op chemotheray, post-op radiotherapy Neuron specific enlase, chromogranin A, negative keratin, somatostatin, S-100
(21) F 19 NS NS 23 Left occipital, parietal, right frontal lobes Altered mental status None NS
(22) M 53 Unilateral 53 73 Right parietal lobe Loss of cognitive function,ahomonymous hemianopsia and left sided dysmetria Resection, whole brain radiotherapy NS
(23) M 29 Unilateral 29 57 Left parietal lobe Headachesm right hemiparesis, aphasia, dysartria Pre-op stereotactic radiosurgery,resection Chromagranin A,synaptophysin, S100
(24) M 10 Unilateral 11 24 Right posterior epidural parietal region None Resection Synaptophysin, chromogranin
(25) M 52 Unilateral 51 52 Left parietal lobe, bilateral cerebral hemisphere, right pons Headaches dizziness, motor aphasia Resection of largest lesion, post-op whole brain radiotherapy Synaptophysin, S-100, negative Oligo-2
(26) F 27 Unilateral 27 29 Extradural lesion attached to the tentorium Headaches, vomiting, static and kinetic cerebellar syndrome Resection, post-op whole-body radiotherapy Synaptophysin, chromogranin, neuron-specific enolase
(27) M NS Unilateral 55 60 Left temporal lobe Scalp mass Resection Vimentin, Syn and CgA, negative S-100, EMA and CD10
(28) M 31 Unilateral 31 31 Right frontal bone Elevated urine metanephrine on routine check-up Resection chromogranin, synaptophysin
Presented case M 24 Unilateral 24 41 Right frontotemporal region Hypertension, progressive left-sided weakness Resection Vimentin, CD10, chromogranin A, synaptophysin, negative GATA3, Melan A, CAM 5.2, TTF1, CK-PAN, S-100

NS, not specified.

 Spinal metastases

Thirty-five studies (1944–2024) reported 60 cases ( Table 2 ). The mean age at PCC diagnosis was 40.5 years (SD, 15.4; median, 42; range, 11–68 years), and metastases occurred at 44.5 years (SD 16.0, median 44, range 9–74) ( Figure 3 ), with a 4-year latency. Adrenalectomy occurred in 36.7% (n=22, mean age 42.1 years, SD 18.3), 13.3% (n=8) had none, and 50% (n=30) were unspecified. Genetics included an 8.3% predisposition (n=5, VHL 1.7% [n=1], NF1 3.3% [n=2]). The laterality was unspecified (63.3%, n=38), unilateral (31.7%, n=19), or bilateral (5%, n=3). The metastases were multiple (53.3%, n=32) or mean 1.7 lesions (SD 1.5, median 1, range 1–7). A total of 72 spinal metastases were recorded, nearly half of which were located in the thoracic spine (47.2%, n=34). No strong linear correlation was found between the co-occurrence of multiple tumors ( Supplementary Correlation Matrix 1 ). The symptoms included hypertension (51.7%, n=31), headaches (13.3%, n=8), tachycardia (10%, n=6), and sweating/tremors (3.3%, n=2 each) ( Figure 4 ). Imaging included non-contrast CT (41.7%, n=25), contrast CT (6.7%, n=4), non-contrast MRI (31.7%, n=19), contrast MRI (16.7%, n=10), and PET (21.7%, n=13), for a total of 71 modalities.

details the data from 35 studies (1977–2024, 60 patients) on spinal pheochromocytoma metastases, including patient characteristics, symptoms, imaging findings, metastasis details, treatments, and outcomes.

Reference Sex Age at initial diagnosis Laterality Age at resection/adrenalectomy Age at metastasis diagnosis Location of spinal metastasis Symptoms Treatment Immunohistochemistry results
(29) M 14 unilateral no adrenalectomy 14 T5, T6 vertebral body Hypertension, partial paraplegia Laminectomy, subtotal resetion, chemotherapy NS
(30) F NS NS No adrenelectomy 39 C2-C3 Hypertension, headaches, hemiplegia, palpitation, dizziness, nausea, mild cardiomegaly, Babinski’s sign, retinal bleeding, papillary edema Symptomatic treatment NS
(31) M 64 Unilateral 64 65 T7 body and pedicles Hypertension, anorexia, constipation, weight loss Laminectomy NS
(32) M NS NS NS 38 C6 body NS Percutaneous embolization of the tumor NS
(33) F 47 Unilateral 47 51 S1-S4 Hypertension Radiotherapy NS
(34) M 15 Bilateral 15 27 T2 Hypertension, paraparesis with spasticity, positive Babinski's sign bilaterally, blindness of the right eye and diminished vision of the left eye Surgery Synaptophysin
(35) M 53 NS 53 65 T11 Left abdominal pain Radiotherapy Chromogranin A
(36) M 47 Bilateral 47 47 T8 Hypertension, headaches, tremors, palpitation, flushing, shivers, urinary incontinence, anxiety attacks, pain and numbness, paraparesis hyperactive patella and achille reflexes, Babinski’s sign and clonus on the right side, hypoesthesy under T8 level Laminectomy, resection NS
(37) M 68 Unilateral 68 69 C6-C7 body Weakness, paresthesia of upper limbs Vertebrectomy, stabilisation and plate fixation, resection, radiotherapy NS
(38) M 42 Unilateral 42 47 T2 body Hypertension, urinary hesitancy, dysuria, weakness and numbness over the trunk and lower limbs, spastic paresis Laminectomy, decompression, stereotactic radiotherapy Synaptophysin, chromogranin
(39) M NS unilateral 34 38 Lumbar spine Pain Percutaneous osteoplasty NS
(40) F 12 NS NS 34 T9 body, pedicles, lamina Hypertension, circumferential back pain Fixiation, resection NS
(41) F 48 NA No adrenalectomy 53 T1, T5, T10, T12 body Hypertension, headache, tremors, palpitations, paresthesia, ftigue, flushing Resection, fixation, cement-augmentation, auxiliary radiotherapy NS
(42) M 11 NS NS 9 T10 body, pedicles Hypertension, back pain Laminectomy, sympathectomy, arthrodesis NS
(43) F 66 Unilateral 66 74 T10 Hypertension, pain in right hip with decreased range of motion Radiotherapy, denied further intervention NS
(44) M 35 NS NS 40 Entire axial spine Axial spine pain, constipation Cisplatin (200mg in total) injection NS
(5) M 28 NS NS NS L3, L4 Abdominal and low-back pain Embolization of the vascular supply NS
(5) M 41 NS 41 41 T1, T4–7, lumbar spine Upper-back pain Preoperative embolization, posterior C4–T10 instrumentation, anterior vertebral body resection NS
(5) F 21 NS NS 21 Entire axial spine Hypertension at the end of pregnancy Posterior decompression and fusion, resection NS
(5) F 62 NS 68 66 Cervical spine, L1 body Hypertension, palpitations, shortness of breath Preoperative embolization of the spinal tumor, left lateral retroperitoneal corpectomy with resection, fusion NS
(5) M 23 NS 11 23 T-10 body Hypertension, bloody stool and back pain Embolization of intersegmental arteries, posterior fusion with vertebrectomy and cage placement NS
(45) F 56 Unilateral NS 56 T7, L1, L5 pedicles, S2 Hypertension, headaches, lower back pain, right-sided sciatica, right foot drop Decompressive laminectomy with tumor debulking, rhizolysis, fixation, radiotherapy Synaptophysin, chromogranin A, CD17, CK5/6, plasma metanephrine and Ki-67
(46) F 26 unilateral no adrenalectomy 26 T8 body, T11-T12 body Numbness and decreased muscle strength of lower limbs, urinary incontinence, lower back and hip pain Posterior decompression, fixation, pedicle srews Hematoxylin, eosin, chromogranin A staining, synaptophysin staining
(46) F 26 unilateral (right) NS NS T8, T11-T12 Headaches, acute numbness and decreased muscle strength of lower limbs, urinary incontinence Palliative radiotherapy and chemotherapy, circumferential spinal cord decompression, stabilization CgA, S-100,chromogranin, p53 and Syn;
(47) M 54 unilateral 54 58 Sacrum body and posterior elements Hypertension, tachycardia, progressive radiating back pain, right lower limb numbness Embolization, cement augmentation, circumferential decopmression Chromogranin A staining, synaptophysin staining
(47) M 58 NS NS NS Sacrum Hypertension, progressive back pain, radiating pain, and numbness of right lower limb Embolisation, osteoplasty, exploratory surgery, circumferential spinal cord decompression, stabilization, revision surgery CgA, S-100,CD56, p53 and Syn;
(48) F 48 Unilateral 48 66 T10 body Hypertension, headaches, lower back pain, chest pain Radiotherapy, chemotherapy NS
(49) F 31 NS NS NS L3 Hypertension, paroxysmal headaches, low back pain Dorsal instrumentation CgA, S-100,CD56, NSE, vimentin and Syn;
(49) M 58 NS NS NS Sacrum Hypertension, progressive low back pain, radiating pain and numbness of lower limbs Dorsal instrumentation, cement augmentation, circumferential decompression CgA, S-100,CD56, NSE, vimentin and Syn;
(49) F 26 NS NS NS T8, T11, T12 Paroxysmal hypertension, acute incomplete paralysis Dorsal instrumentation CgA, S-100,CD56, NSE, vimentin and Syn;
(49) M 32 NS NS NS T4 Progressive paraplegia and numbness of the lower limbs Posterior decompression, resection, internal fixation CgA, S-100,CD56, NSE, vimentin and Syn;
(49) M 59 NS NS NS T9, T10 Progressive back pain, numbness and decreased muscle strength of lower limbs Posterior decompression, resection, internal fixation CgA, S-100,CD56, NSE, vimentin and Syn;
(49) M 63 NS NS NS T2, T4, T7, L1, L3, sacrum Hypertension, progressive lower back pain Percutaneous vertebroplasty CgA, S-100,CD56, NSE, vimentin and Syn;
(49) M 27 NS NS NS T1, T12, L1, L4 Back pain, decreased muscle strength of lower limbs Percutaneous vertebroplasty, posterior decompression, resection internal fixation CgA, S-100,CD56, NSE, vimentin and Syn;
(49) F 22 NS NS NS T5 Headache, back pain Percutaneous vertebroplasty CgA, S-100,CD56, NSE, vimentin and Syn;
(49) M 60 NS NS NS T11, L1 L3, L5 Numbness of both legs Percutaneous vertebroplasty, posterior decompression, resection, internal fixation CgA, S-100,CD56, NSE, vimentin and Syn;
(49) M 38 NS NS NS Sacrum Sacrococcygeal pain Biopsy, refused surgery CgA, S-100,CD56, NSE, vimentin and Syn;
(50) M 19 Unilateral No adrenelectomy 19 Thoracic, lumbar, sarcal Hypertension, tachycardia, headaches, decreased sensation and weakness of lower extremities NS NS
(51) M 43 unilateral No adrenelectomy 42 NS Hypertension, tachycardia, headaches, pathologic hip and femur fractures, limited mobility, red face, lower extermity edema Chemotherapy (cyclophosphamide, vincristine, dacarbazine, zoledronic acid) Hematoxylin, eosin
(52) F 33 NA No adrenalectomy 33 T3 Hypertension, tachycardia, decreased muscle strength of lower limbs, hypoesthesia below T7, increased tendon reflexes Biopsy, Abandoned resection NS
(53) F 27 unilateral 27 40 L2 body Hypertension, cauda equina syndrome Emergency decompression, resection NS
(54) F NS unilateral no adrenalectomy 34 L4, L5 Tachycardia, sweating, suspected preclampsia, spine and shoulder pain Fusion, chemotherapy NS
(55) M 32 NS NS 38 NS Pain Percutaneous vertebroplasty NS
(55) M 42 NS NS 48 NS Pain, neurological deficits Decompression, partial resection NS
(55) F 47 NS NS 49 C2 Pain Resection NS
(55) M 50 NS NS 51 T2 Hypertension, pain, neurological deficits Decompression, partial resection NS
(55) F 55 NS NS 63 L4 Hypertension, pain, neurological deficits Decompression, partial resection NS
(55) M 30 NS NS 37 T12 Pain Partial resection NS
(55) M 57 NS NS 62 T5 Hypertension, pain, neurological deficits Decompression, partial resection NS
(55) M 46 NS NS 70 C1 Hypertension, pain Partial resection NS
(55) F 42 NS NS 44 T4 Neurological deficits Decompression, partial resection NS
(55) F 42 NS NS 46 L1 Pain, neurological deficits Decompression, partial resection NS
(56) M 38 Unilateral 38 41 L3 body Lower back pain, numbness and decreased muscle strength and sensation in lower extremities Total en-bloc spondylectomy, implantation of a patient-individual 3D-printed artificial vertebral body, stabilization Synaptophysin and chromogranin A, negative cytokeratin, epithelial membrane antigen, other markers were negative
(57) M NS NS 11 13 T3 Lower limb mobility disorder Resection, titanium filled with bone allograft NS
(57) M NS NS NS 58 S1, S2 Sacrococcygeal pain Resection, pedicle screws NSE
(57) M NS NS 22 40 T3 Lower limb mobility disorder Resection, titanium filled with bone cement, radiotherapy NS
(57) M NS NS 23 42 L1, L2 Lower limb mobility disorder Resection, pedicle screws, radiotherapy Inhibin a, SF-1 and Syn;
(58) F 36 Bilateral 36 44 Axial skeleton Hypertension, tachycardia, cafe au lait spots, palpitations, generalized body pain, dizziness, presyncope Symptomatic treatment NS
(6) M NS Unilateral 64 65 C6 Hypertension, sweating, neck pain, left arm and leg weakness with paresthesia, and urinary incontinence Preoperative embolization, laminectomy, resection, posterior spinal fusion NS
(59) M 46 Unilateral 46 46 T1-T2 body, T12 arch Right-sided abdominal pain NS CgA
Presented case M 43 Unilateral No adrenalectomy 44 L1 Tachycardia, hypothyroidism, lower back pain Laminectomy, corpectomy, stabilization, fixiation Synaptophysin, IMSM1, Vimentin, negative AE1/3, S-100, SOX10, TTF1, Inhibin, CD10, Ki67 ~ 15%

Age at diagnosis of pheochromocytoma CNS metastasis.

Histogram showing the age at diagnosis of pheochromocytoma CNS metastases. Cranial data has a mean age of 46.6 years and a standard deviation of 14.1, depicted in purple. Spinal data has a mean age of 44.5 years and a standard deviation of 16.0, depicted in yellow. Frequency is on the y-axis and age in years is on the x-axis.

Prevalence of symptoms in pheochromocytoma CNS metastases.

Bar chart showing symptom prevalence in pheochromocytoma CNS metastases. Symptoms include headaches, hypertension, tachycardia, sweating, and tremors, compared between cranial (blue) and spinal (orange) cases. Hypertension is most prevalent in spinal cases, and headaches in cranial cases. Discussion

Pheochromocytoma metastases to the brain and spine are exceptionally rare, representing uncommon destinations for the malignant spread of NETs. This systematic review encompassed 35 studies from 1977 to 2024 (60 spinal cases) and 18 studies from 1948 to 2022 (18 cranial cases), along with one case report, consolidating sparse data to highlight distinct clinical, diagnostic, and therapeutic challenges of CNS involvement in malignant (mPCC) (1). Unlike more frequent metastatic sites, such as the liver or non-spinal skeleton, brain and spinal metastases pose unique complexities due to their potential to impair neurological function, disrupt spinal stability, or both (1). These challenges are exemplified by the case of a 41-year-old male with right frontoparietal brain metastasis causing progressive left-sided weakness. This case underscores the need for heightened diagnostic vigilance and tailored management strategies to address this rare metastatic site (1).

Clinical presentation and symptom variability

The clinical presentation of mPCC metastases varies significantly by site, reflecting the local anatomical and physiological impacts. Cranial metastases, as seen in our case and reported in 18 patients, predominantly manifest with neurological symptoms such as headaches (44.4%, n=8) and focal deficits (e.g., described case’s weakness), with hypertension present in only 27.8% (n=5) and no reports of tachycardia or tremors. This neurological predominance, often associated with solitary lesions (55.6%, n=10), contrasts with the systemic catecholamine-driven symptoms typical of classical PCC. Spinal metastases, analyzed in 60 patients, more frequently present with hypertension (51.7%, n=31), headaches (13.3%, n=8), and tachycardia (10%, n=6), consistent with catecholamine excess (10). This dichotomy—neurological deficits in cranial cases versus structural and pain-related issues in spinal cases—emphasizes the need for clinicians to consider mPCC in PCC patients presenting with neurological symptoms or intractable back pain, even in the absence of classical features (10).

 Diagnostic challenges and imaging evolution

Diagnosing CNS mPCC metastases is challenging because of their rarity, nonspecific symptoms, and evolution of imaging modalities (5). Historically, spinal cases have often utilized non-contrast CT (41.7%, n=25) for its accessibility, despite its limited soft tissue resolution, compared to contrast-enhanced MRI, which accurately delineates epidural spinal cord compression and instability, guiding surgical planning (5). MRI (16.7%, n=10) and PET (21.7%, n=13) were underutilized in spinal cases but offered superior detailed and metabolic insights, as recommended by the current guidelines (60). For cranial metastases, MRI was critical in our case, although the review’s imaging data were incomplete, variably mentioning MRI and CT findings. The prolonged latency between initial PCC diagnosis and metastasis—11.6 years for cranial (mean age 46.6 years, SD 14.1) and 4 years for spinal (mean age 44.5 years, SD 16)—is reflected in the 17-year interval post-adrenalectomy (5). These extended intervals underscore the importance of long-term surveillance, prioritizing MRI for suspected CNS metastases to assess neurological and structural involvement, supplemented by CT for spinal bony anatomy, and PET for systemic staging (60). The historical reliance on CT and underutilization of advanced imaging highlights the diagnostic gap that modern protocols must address (9).

 Surgical management and outcomes

Surgical management remains the cornerstone of both cranial and spinal mPCC and is tailored to address site-specific deficits (6). The neuronavigation-assisted frontoparietal tumor resection with cranioplasty preserved neurological function, aligning with the review’s high surgical prevalence for cranial metastases (72.2%, n=13), often supplemented by radiotherapy (38.9%, n=7) or chemotherapy (11.1%, n=2) (6). The focal nature of spinal lesions (mean 1.7, SD 1.5) suggests amenability to targeted intervention, but our case’s prior recurrences emphasize the need for meticulous preoperative optimization to mitigate catecholamine surges, which is a critical consideration in CNS mPCC surgeries (6). Systemic therapies, such as 177Lu-DOTATATE in the described Case, and radiotherapy show promise for unresectable or recurrent disease, warranting further exploration (6).

 Histopathological insights and genetic context

Histopathologically, CNS metastatic pheochromocytoma (mPCC) consistently exhibits neuroendocrine marker expression. Described Case’s cranial lesion (Chromogranin A++, Synaptophysin++, Vimentin++) aligns with the systematic review’s findings, which reported Chromogranin A in 10 cranial cases and Synaptophysin in 7, confirming diagnostic consistency (2). However, the lack of comparative proliferation data, such as Ki67 levels, limits its prognostic utility. Genetically, hereditary syndromes are rare in cranial cases, with only 16.7% (n=3) showing predisposition and none linked to von Hippel-Lindau syndrome (2). Described in this study Case exhibited no genetic predisposition, consistent with most cases. The absence of SDHB mutation testing, a known malignancy risk factor, reflects a common gap in the historical data, restricting risk stratification (2, 3). Routine genetic profiling, particularly for SDHB, could identify patients at a higher risk of CNS metastases, thereby enhancing surveillance and management (3).

 Limitations and future directions

The rarity of cranial metastatic pheochromocytoma (mPCC) poses significant limitations, with a small sample size (18 cranial cases) and extended study periods (1944–2024), leading to incomplete reporting, including 33% of missing follow-up data (61). The historical preference for non-contrast CT over MRI or PET reduces diagnostic precision, whereas inconsistent genetic testing (e.g., SDHB) limits comprehensive risk assessment (9). These gaps underscore the need for prospective studies to standardize diagnostic and therapeutic protocols (61). Interdisciplinary collaboration—integrating neurosurgery, endocrinology, oncology, radiotherapy, and potentially plastic surgery for soft tissue reconstruction after spinal procedures—could optimize functional outcomes and quality of life (61). International registries and collaborative research are essential to address these uncommon metastatic sites and improve the detection, management, and survival in this rare malignancy.

 Conclusions

This systematic review and case report highlights the rarity of pheochromocytoma metastases to the brain and spine, emphasizing distinct clinical presentations (neurological for cranial and pain-driven for spinal), the critical role of MRI and PET in diagnosis, and the necessity of tailored surgical interventions. Despite diagnostic and data limitations, the findings advocate for long-term surveillance, advanced imaging, and multidisciplinary management to optimize outcomes in this challenging malignancy. Prospective studies and international registries are needed to standardize care and improve prognoses.

 Data availability statement

The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding author.

 Author contributions

JFe: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing. OC: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing. JC-G: Data curation, Writing – review & editing. DP: Data curation, Writing – review & editing. BJ: Data curation, Writing – review & editing. KK: Writing – review & editing. MM: Project administration, Writing – review & editing. MM-G: Writing – original draft, Writing – review & editing. JS: Writing – review & editing. AS: Writing – review & editing. TS: Supervision, Writing – review & editing. MS: Supervision, Writing – review & editing. JFu: Supervision, Writing – review & editing.

 Funding

The author(s) declare that no financial support was received for the research and/or publication of this article.

 Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

 Correction note

A correction has been made to this article. Details can be found at: 10.3389/fendo.2025.1694463.

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 Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fendo.2025.1633411/full#supplementary-material.

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