AUTHOR=Xu Jia , Li Hao , Qi Hualin , Zhao Xinhui 

TITLE=Prediction model for cognitive impairment in maintenance hemodialysis patients: the role of diabetes

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1594605

DOI=10.3389/fendo.2025.1594605

ISSN=1664-2392

ABSTRACT=ObjectiveThe aim of this study was to identify risk factors for cognitive impairment (CI) in maintenance hemodialysis (MHD) patients and to develop a predictive model.MethodsA total of 151 MHD patients from our hospital were recruited between July 2020 and April 2021. Sociodemographic, clinical, and laboratory data were collected. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), whereas physical performance was evaluated using handgrip strength, the Timed Up and Go Test (TUGT), and 4-m gait speed. Univariate and multivariate logistic regression analyses identified risk factors, which were used to develop original and simplified predictive models.ResultsCI was present in 43 patients (28.5%). The simplified model demonstrated discriminatory ability comparable to that of the original model (AUC: 0.737; 95% CI: 0.648–0.818) and was easier to use. A robust nomogram was developed on the basis of the simplified model. Decision curve analysis (DCA) confirmed the clinical utility of both models. Diabetes was identified as an independent risk factor, whereas dialysis duration was not associated with CI.ConclusionsThis study provides a simple predictive model for CI in MHD patients, which could aid in clinical decision-making.