Front. Endocrinol. Frontiers in Endocrinology Front. Endocrinol. 1664-2392 Frontiers Media S.A. 10.3389/fendo.2024.1491855 Endocrinology Erratum Erratum: Addressing chemically-induced obesogenic metabolic disruption: selection of chemicals for in vitro human PPARα, PPARγ transactivation, and adipogenesis test methods Frontiers Production Office * Frontiers Media SA, Lausanne, Switzerland

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25 10 2024 2024 15 1491855 05 09 2024 05 09 2024 Copyright © 2024 Frontiers Production Office 2024 Frontiers Production Office

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 An Erratum on Addressing chemically-induced obesogenic metabolic disruption: selection of chemicals for in vitro human PPARα, PPARγ transactivation, and adipogenesis test methods By Ozcagli E, Kubickova B and Jacobs MN (2024). Front. Endocrinol. 15:1401120. doi: 10.3389/fendo.2024.1401120 adipogenesis obesogen peroxisome proliferator-activated receptor metabolic disruption integrated testing strategy test guideline validation section-in-acceptance Molecular and Structural Endocrinology

Due to a production error, there was a mistake in Tables 2A–C as published. The molecular structures were incorrectly placed in these tables. The corrected Tables 2A–C appear below.

Selected chemicals and activity bands for the PPARα assay.

Chemical Cas No. Structure Use hPPARαag/antag ● inactive ○
Negative
Bisphenol A (BPA) 80-05-7 Plasticiser, industrial chemical -
Triphenylphosphate (TPP) 115-86-6 Industrial chemical -
Dichlorodiphenyldichloroethylene (pp’-DDE) 72-55-9 Pesticide metabolite (Stockholm POPs list) -
Triclosan (TCS) 3380-34-5 Bacteriocide -
Rosiglitazone (ROSI) 122320-73-4 Pharmaceutical -
Chlorpyrifos (CPF) 2921-88-2 Organophosphate pesticide -
Perfluorohexanoic acid (PFHXA) 307-24-4 Breakdown product of PFAS -
(aR)-4-chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid, (MBX-102/JNJ39659100) Arhalofenate MBX-102 24136-23-0 Experimental pharmaceutical -
Tetrabrominated BPA (TBBPA) 79-94-7 Flame retardant -/?
LGD1069 (Targretin) Bexarotene 153559-49-0 Pharmaceutical -
Weak activity
Phytanic acid 14721-66-5 Dietary lipid + Very weak agonist 10-4 µM
Clofibrate 637-07-0 Pharmaceutical, fibrate + Weak-moderate agonist up to 10-4 µM
AGN194204 (IRX4204) 220619-73-8 Pharmaceutical Weak antagonist
Weak to moderate activity
Mono-(2-Ethylhexyl) Phthalate (MEHP) 4376-20-9 Phthalate, plasticiser + Moderate agonist
Eicosapentaenoic acid (EPA) 10417-94-4 Nutrient, long chain PUFA essential fatty acid + Moderate agonist
Tesaglitazar/AZ242 251565-85-2 Pharmaceutical + Selective moderate agonist3 µM
Clofibric acid 882-09-7 Herbicide and pharmaceutical; active metabolite of clofibrate + Moderate agonist (EC50 = 50.0 µM)
Strong activity
Perfluorooctanoic acid (PFOA) 335-67-1 Industrial chemical, non-stick coating + Strong agonist
Pristanic acid 1189-37-3 Dietary lipid + Strong agonist1 µM
Docosahexaenoic acid (DHA) 6217-54-5 Nutrient, long chain PUFA essential fatty acid + Strong agonist
Positive control
GW7647 265129-71-3 Pharmaceutical candidate + Selective agonist, positive control10 nM

Selected chemicals and activity bands for the PPARγ assay.

Chemical Cas No. Structure Use hPPARγ ag/antag ● inactive ○
Negative
Bisphenol A (BPA) 80-05-7 Plasticiser, industrial chemical -
Dichlorodiphenyldichloroethylene (pp’-DDE) 72-55-9 Pesticide metabolite (Stockholm POPs list) -
Triclosan (TCS) 3380-34-5 Bacteriocide -
Perfluorohexanoic acid (PFHXA) 307-24-4 Breakdown product of PFAS -
LGD1069 (Targretin) Bexarotene 153559-49-0 Pharmaceutical -
Weak activity
Chlorpyrifos (CPF) 2921-88-2 Organophosphate pesticide + Weak agonist
Clofibrate 637-07-0 Pharmaceutical, fibrate + Weak-moderate agonist
Phytanic acid 14721-66-5 Dietary lipid + Weak-moderate agonist
(aR)-4-chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid, (MBX-102/JNJ39659100) Arhalofenate MBX-102 24136-23-0 Experimental pharmaceutical + Weak agonist
GW3965 hydrochloride 405911-17-3 Pharmaceutical candidate + Weak agonist
Weak to moderate activity
Mono-(2-Ethylhexyl) Phthalate (MEHP) 4376-20-9 Phthalate, plasticiser + Moderate agonist
GW7647 265129-71-3 Pharmaceutical candidate + Moderate agonist
Eicosapentaenoic acid (EPA) 10417-94-4 Nutrient, long chain PUFA essential fatty acid + Moderate agonist
Clofibric acid 882-09-7 Herbicide and pharmaceutical; active metabolite of clofibrate + Weak-Moderate agonist (but weaker than PPARα)
Pristanic acid 1189-37-3 Dietary lipid + Weak-moderate agonist10 µM
Strong activity
Triphenyl phosphate (TPP) 115-86-6 Industrial chemical: Adhesives and sealants, coating products, cosmetics and personal care products + Strong agonist
Docosahexaenoic acid (DHA) 6217-54-5 Nutrient, long chain PUFA essential fatty acid + Strong agonist
Tetrabrominated BPA (TBBPA) 79-94-7 Flame retardant + Strong agonist
Perfluorooctanoic acid (PFOA) 335-67-1 Industrial chemical, non-stick coating + Strong agonist
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) 87893-55-8 Metabolite of endogenous prostaglandin (PGJ2) + Strong agonist
Tesaglitazar/ AZ 242 251565-85-2 Pharmaceutical + Strong agonist40 nM
Positive control
Rosiglitazone (ROSI) 122320-73-4 Pharmaceutical + Positive control

Selected chemicals and activity bands for the hMSC adipogenesis assay.

Chemical Cas No. Structure Use hMSC adipogenesis (lipid accumulation)ag/antag ● inactive ○
Negative
Triclosan (TCS) 3380-34-5 Bacteriocide -
TTNPB, 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl] benzoic acid, Arotinoid acid 71441-28-6 Pharmaceutical -Strong inhibitor of adipogenesis; unlike retinoic acids (9cRA) that promotes adipogenesis
Dichlorodiphenyldichloroethylene (pp’-DDE) 72-55-9 Pesticide metabolite (Stockholm POPs list) ?-
Chlorpyrifos (CPF) 2921-88-2 Organophosphate pesticide -
Weak activity
Perfluorooctanoic acid (PFOA) 335-67-1 Industrial chemical, non-stick coating + Weak inducer
Weak to moderate activity
GW3965 hydrochloride 405911-17-3 Pharmaceutical candidate + Weak/moderate inducer
Tetrabrominated BPA (TBBPA) 79-94-7 Flame retardant +Moderate inducer10 μM induced adipogenesis in 3T3-L1 cells
Mono-(2-Ethylhexyl) Phthalate (MEHP) 4376-20-9 Phthalate, plasticiser + Moderate10 μM and was maximal at 100 μM
Triphenyl phosphate (TPP) 115-86-6 Industrial chemical: Adhesives and sealants, coating products, cosmetics and personal care products + Agonist at high dose (>1µM)
Strong activity
Fludioxonil 131341-86-1 Non-systemic fungicide + Strong (significant at 0.2 µM)
Tributyltin (TBT) chloride 1461-22-9 Fungicide + Strong inducer adipogenic differentiation (3T3-L1)
Positive control
Rosiglitazone (ROSI) 122320-73-4 Pharmaceutical + Positive control

The publisher apologizes for this mistake.

The original version of this article has been updated.