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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Educ.</journal-id>
<journal-title>Frontiers in Education</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Educ.</abbrev-journal-title>
<issn pub-type="epub">2504-284X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/feduc.2024.1390892</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Education</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Educational data mining: factors influencing medical student success and the exploration of visualization techniques</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Rueangket</surname> <given-names>Ploywarong</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1182278/overview"/>
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<role content-type="https://credit.niso.org/contributor-roles/project-administration/"/>
<role content-type="https://credit.niso.org/contributor-roles/software/"/>
<role content-type="https://credit.niso.org/contributor-roles/visualization/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Thaebanpakul</surname> <given-names>Chulaluck</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
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</contrib>
<contrib contrib-type="author">
<name><surname>Sakboonyarat</surname> <given-names>Boonsub</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Prayote</surname> <given-names>Akara</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
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<aff id="aff1"><sup>1</sup><institution>Department of Obstetrics and Gynecology, Phramongkutklao Hospital</institution>, <addr-line>Bangkok</addr-line>, <country>Thailand</country></aff>
<aff id="aff2"><sup>2</sup><institution>Department of Military and Community Medicine, Phramongkutklao Hospital</institution>, <addr-line>Bangkok</addr-line>, <country>Thailand</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Computer and Information Science, King Mongkut's University of Technology North Bangkok</institution>, <addr-line>Bangkok</addr-line>, <country>Thailand</country></aff>
<author-notes>
<fn fn-type="edited-by" id="fn0001">
<p>Edited by: Michael Kickmeier-Rust, University of Teacher Education St. Gallen, Switzerland</p>
</fn>
<fn fn-type="edited-by" id="fn0002">
<p>Reviewed by: Can Mese, Kahramanmara&#x015F; Istiklal University, T&#x00FC;rkiye</p>
<p>Ashraf Alam, Indian Institute of Technology Kharagpur, India</p>
</fn>
<corresp id="c001">&#x002A;Correspondence: Ploywarong Rueangket, <email>ploywarong.24@gmail.com</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>19</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>9</volume>
<elocation-id>1390892</elocation-id>
<history>
<date date-type="received">
<day>24</day>
<month>02</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>18</day>
<month>11</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2024 Rueangket, Thaebanpakul, Sakboonyarat and Prayote.</copyright-statement>
<copyright-year>2024</copyright-year>
<copyright-holder>Rueangket, Thaebanpakul, Sakboonyarat and Prayote</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec id="sec1">
<title>Objectives</title>
<p>Medical student education is critical in equipping future doctors to impact patient healthcare and the national public health system significantly. This study aimed to identify factors influencing student academic success (honors level or high-grade group) among medical students using data mining techniques applied to multidimensional educational data.</p>
</sec>
<sec id="sec2">
<title>Materials and methods</title>
<p>A retrospective cohort study was conducted using a standardized questionnaire administered to 145 medical students. A total of 13 factors spanning four domains&#x2014;academic activity, demographics, environment, and psychology or learning style&#x2014;were examined. The prevalence ratio (PR) and adjusted prevalence ratio (APR) were calculated using multivariate logistic regression. Unsupervised learning techniques, including cluster analysis and association rules, were used to identify hidden patterns. Visualization techniques, such as heatmaps and centroid plots derived from cluster analysis, were employed to depict data relationships and facilitate the interpretation of key trends. Internal validation was also evaluated.</p>
</sec>
<sec id="sec3">
<title>Results</title>
<p>Among the 13 factors analyzed, logistic regression identified a pre-med GPAX &#x2265;3.75 and an interest in internal medicine as statistically significant predictors of high academic performance, with adjusted prevalence ratios (APRs) of 1.73 (95% CI, 1.02&#x2013;2.91, <italic>p</italic>&#x202F;=&#x202F;0.040) and 1.52 (95% CI, 1.14&#x2013;2.03, <italic>p</italic>&#x202F;=&#x202F;0.005), respectively. Cluster analysis revealed characteristic traits of high-grade students, including metropolitan residence, very high pre-med GPAX, and a preference for kinesthetic and reading learning styles. Association rules analysis further emphasized the importance of environmental factors, particularly transportation time to school and access to learning resources, in supporting academic success.</p>
</sec>
<sec id="sec4">
<title>Conclusion</title>
<p>Educational data mining (EDM) provided valuable insights into factors contributing to medical student success. Logistic regression highlighted pre-med GPAX and an interest in internal medicine as key predictors. Cluster analysis uncovered patterns linking learning styles and academic performance, while association rules emphasized the role of environmental factors, such as school proximity and resource availability. Together, these methods provide a comprehensive and visually engaging framework to inform educational planning, potentially generating novel insights for addressing medical challenges and enhancing clinical practice.</p>
</sec>
</abstract>
<kwd-group>
<kwd>educational data mining</kwd>
<kwd>medical student</kwd>
<kwd>logistic regression</kwd>
<kwd>unsupervised learning techniques</kwd>
<kwd>visualization techniques</kwd>
</kwd-group>
<counts>
<fig-count count="5"/>
<table-count count="6"/>
<equation-count count="3"/>
<ref-count count="44"/>
<page-count count="14"/>
<word-count count="7527"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Digital Education</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec5">
<title>Introduction</title>
<p>Competent medical students are essential for cultivating a skilled cadre of doctors who not only contribute directly to patient healthcare but also enhance collaboration within the national public health system.</p>
<p>To achieve these goals, most medical institutions strive to develop optimal educational programs that achieve academic success and professionalism. Addressing the complexity of multifactorial data is a critical challenge in this process. As a result, the introduction of educational data mining (EDM) has gained attention as a promising solution.</p>
<p>EDM is an emerging interdisciplinary research area that involves education and computer science, with the ability to extract and convert large amounts of educational data into useful patterns of information and important knowledge. Various tasks are involved, such as description, prediction, estimation, classification, clustering, and association discovering, leading to the development of numerous techniques, including regression, na&#x00EF;ve Bayes, decision trees, neural networks (NN), K-means, Apriori, FP-Growth, and many more (<xref ref-type="bibr" rid="ref4">Aleem and Gore, 2020</xref>). Until now, several applications of EDM have emerged, such as regression models for graduate-level performance prediction (<xref ref-type="bibr" rid="ref44">Zimmermann et al., 2015</xref>), association rule mining for teaching assessment (<xref ref-type="bibr" rid="ref43">Sy and Que, 2019</xref>), and cluster analysis for learning style classification (<xref ref-type="bibr" rid="ref9">Beal et al., 2006</xref>).</p>
<p>While various definitions of student success exist in the literature, they focus primarily on academic achievements and professionalism, and the latter is difficult to measure (<xref ref-type="bibr" rid="ref31">Kuh et al., 2006</xref>; <xref ref-type="bibr" rid="ref6">Alyahyan and D&#x00FC;&#x015F;teg&#x00F6;r, 2020</xref>). Student achievement is commonly addressed using the grade point average (GPA), which remains a crucial consideration for postgraduate training programs such as residency and fellowship (<xref ref-type="bibr" rid="ref32">McGaghie, 2019</xref>).</p>
<p>Numerous studies in the literature have explored influential factors based on learning, cognitive, and behavioral theories for predicting academic success (<xref ref-type="bibr" rid="ref30">Kolb, 2014</xref>). Our research primarily concentrates on four domains: academic activity, demographics, environment, and psychology or learning style. These domains are frequently reported as predictive or associated with our outcomes in numerous systematic literature reviews (<xref ref-type="bibr" rid="ref6">Alyahyan and D&#x00FC;&#x015F;teg&#x00F6;r, 2020</xref>; <xref ref-type="bibr" rid="ref8">Baashar and Alkawsi, 2021</xref>; <xref ref-type="bibr" rid="ref22">Hellas et al., 2018</xref>; <xref ref-type="bibr" rid="ref14">Crisp et al., 2015</xref>), with prior academic achievement and demographics ranking highest (44 and 25%, respectively), followed by environment and psychology or learning style (17 and 11%, respectively) (<xref ref-type="bibr" rid="ref6">Alyahyan and D&#x00FC;&#x015F;teg&#x00F6;r, 2020</xref>). Psychology, or learning style, is defined as the composite of cognitive, affective, and psychological characteristics that are stable indicators of how a learner perceives, interacts with, and responds to the learning environment (<xref ref-type="bibr" rid="ref35">Nguyen, 2013</xref>). Unfortunately, a multifactorial linkage is believed to occur due to the complexity of human behavior and the learning process (<xref ref-type="bibr" rid="ref6">Alyahyan and D&#x00FC;&#x015F;teg&#x00F6;r, 2020</xref>; <xref ref-type="bibr" rid="ref39">Salem et al., 2013</xref>).</p>
<p>Compared to traditional medical education, which relies on passive memorization of content, recent research has introduced more active approaches, emphasizing creativity and innovative active learning (<xref ref-type="bibr" rid="ref23">Hindin et al., 2023</xref>).</p>
<p>Notably, educational analysis could engage with many dimensions and data types, such as categorical data in attitude or learning style and continuous GPA data. Thus, it is a unique tool that can potentially be applied to collect and mine different data types for targeted outcomes.</p>
<p>Definition: Student success is defined as academic achievement, engagement in educationally purposeful activities, satisfaction, acquisition of desired knowledge, skills and competencies, persistence, attainment of educational outcomes, and post-college performance (<xref ref-type="bibr" rid="ref31">Kuh et al., 2006</xref>).</p>
</sec>
<sec sec-type="materials|methods" id="sec6">
<title>Materials and methods</title>
<p>The retrospective cohort study was conducted using an online standardized questionnaire consisting of 13 questions and one learning style test (<xref ref-type="table" rid="tab1">Table 1</xref>). The questionnaire was administered to medical students who graduated from Phramongkutklao College of Medicine between April 2010 and April 2023. It included questions pertaining to specific periods of the 6-year medical student experience and was conducted from January 2022 to April 2023. The study followed a four-step approach, modified from the Foundational Method for Data Science (FMD), IBM 2015, as presented in <xref ref-type="fig" rid="fig1">Figure 1</xref>.</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Study factors with descriptions and data types for analysis.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Domains</th>
<th align="left" valign="top">Attributes/study factors</th>
<th align="left" valign="top">Type of data</th>
<th align="left" valign="top">Descriptions</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="5">Demographics</td>
<td align="left" valign="top">Sex</td>
<td align="left" valign="top" rowspan="14">Categorical</td>
<td align="left" valign="top">Female/Male</td>
</tr>
<tr>
<td align="left" valign="top">BMI status</td>
<td align="left" valign="top">Underweight/Normal/Overweight/Obesity</td>
</tr>
<tr>
<td align="left" valign="top">Relationship status</td>
<td align="left" valign="top">Single/Dating</td>
</tr>
<tr>
<td align="left" valign="top">Family address</td>
<td align="left" valign="top">Metropolis/Others</td>
</tr>
<tr>
<td align="left" valign="top">Family income</td>
<td align="left" valign="top">&#x003C;20,000/20&#x2013;100,000/100,000 THB/month</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Environment</td>
<td align="left" valign="top">Transportation time</td>
<td align="left" valign="top">&#x003C;30/30&#x2013;60/&#x003E;60&#x202F;min</td>
</tr>
<tr>
<td align="left" valign="top">Learning resources</td>
<td align="left" valign="top">Wi-Fi/Computer/iPad</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="6">Academic activities</td>
<td align="left" valign="top">Online learning</td>
<td align="left" valign="top">Hybrid to complete online/None</td>
</tr>
<tr>
<td align="left" valign="top">Attendance</td>
<td align="left" valign="top">Medicine/Obstetrics &#x0026; Gynecology/Surgery/ Pediatrics</td>
</tr>
<tr>
<td align="left" valign="top">Specialties of interest</td>
<td align="left" valign="top">&#x003C;1/ 1&#x2013;2/ &#x003E;2&#x202F;h per day</td>
</tr>
<tr>
<td align="left" valign="top">Time for study</td>
<td align="left" valign="top">1/2/3/4</td>
</tr>
<tr>
<td align="left" valign="top">Course session&#x002A;</td>
<td align="left" valign="top">&#x003C;3.5/3.5&#x2013;3.75/&#x2265;3.75</td>
</tr>
<tr>
<td align="left" valign="top">GPAX in pre-medical school</td>
<td align="left" valign="top">&#x003C; 3.25 (Low grade)/ &#x2265; 3.25 (High grade)</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Psychology</td>
<td align="left" valign="top" rowspan="2">Learning style</td>
<td align="left" valign="top">Conclusion (V/A/R/K)</td>
</tr>
<tr>
<td align="left" valign="top">Integer</td>
<td align="left" valign="top">Visual score (1-16)<break/>Auditory (1-16)<break/>Reading (1-16)<break/>Kinetics (1-16)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>BMI, body mass index; GPAX, accumulated grade point average; THB, Thai Bath.</p>
<p><sup>&#x002A;</sup>Course session: defined by a session of different educational courses (usually modified every 3&#x2013;5&#x202F;years).</p>
</table-wrap-foot>
</table-wrap>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>The study flow diagram adapted from the Foundational Method for Data Science (FMD), IBM 2015 (<xref ref-type="bibr" rid="ref38">Rollins, 2015</xref>; <xref ref-type="bibr" rid="ref20">Foroughi and Luksch, 2018</xref>). DB index, Davies Bouldin; DT, decision tree.</p>
</caption>
<graphic xlink:href="feduc-09-1390892-g001.tif"/>
</fig>
</sec>
<sec id="sec7">
<title>Problem definition and formulation</title>
<p>The primary outcome was academic success, measuring the accumulated grade point average of graduated students in medical school, or GPAX (Med). The factors affecting our outcomes were analyzed from the literature (<xref ref-type="bibr" rid="ref6">Alyahyan and D&#x00FC;&#x015F;teg&#x00F6;r, 2020</xref>; <xref ref-type="bibr" rid="ref39">Salem et al., 2013</xref>) and concluded in four domains: academic activity, demographics, environment, and learning style or psychology. Based on students&#x2019; data, the inclusion criteria were graduation between April 2010 and April 2023 to minimize the recall bias and ensure the voluntary completion of all questionnaire questions. Incomplete questionnaires were excluded. The Royal Thai Army Medical Department Institutional Review Board approved the study, reference number R192h/64_Exp. Student identification was coded before analysis and discussion.</p>
<sec id="sec8">
<title>Outcome of measurement</title>
<p>The GPAX was categorized as either high-grade or honors level and low-grade or average grade using a cutoff of 3.25.</p>
<p>The analysis had two objectives. First, supervised learning with logistic regression was used to classify outcomes based on the probability of occurrence. Second, unsupervised learning was applied using association rules and cluster analysis to gain further insights from the data, allowing for exploration without predetermined outcome labels. Visualization techniques, such as heat maps and centroid plots, were employed to illustrate patterns and relationships identified by supervised and unsupervised methods. For a visual overview of the analytical approach, refer to <xref ref-type="fig" rid="fig2">Figure 2</xref>.</p>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>Conceptual overview of four predictive models.</p>
</caption>
<graphic xlink:href="feduc-09-1390892-g002.tif"/>
</fig>
</sec>
<sec id="sec9">
<title>Logistic regression (LR)</title>
<p>A traditional statistical method invented by a British statistician in 1958, widely used for classification problems via the logistic function (<xref ref-type="bibr" rid="ref13">Cox, 1958</xref>). In this study, logistic regression was selected as an appropriate method to analyze the relationship between multiple predictor variables and a binary outcome&#x2014;academic success. Its capacity to estimate adjusted risk measures or associations while controlling covariates and confounders aligns well with our study objectives. The adjusted prevalence ratio (APR) was used to measure the risk associated with the probability of the outcome occurring (<xref ref-type="bibr" rid="ref37">Petersen and Deddens, 2008</xref>). In addition, the &#x2018;margins&#x2019; command was analyzed to obtain predicted probabilities.</p>
<p>Cluster analysis is a useful tool when dealing with unstructured data. The ability to organize data into homogeneous groups provides immediate insights, patterns, or a foundation for constructing a hypothesis. Our analytical goal is to achieve optimal similarities within each cluster and dissimilarities across clusters while also determining an appropriate number of clusters that offer meaningful clinical information (<xref ref-type="bibr" rid="ref10">Bergman et al., 2003</xref>). The model was validated internally using the Davies Bouldin (DB) index. This calculates the ratio of the average intra-cluster distance for points in two clusters to the distance within the clusters. The lowest DB index represents the optimal number of clusters and often indicates good clustering (<xref ref-type="bibr" rid="ref16">Davies and Bouldin, 1979</xref>). Secondary validation was the average within centroid distance, which involved calculating the average distance between each point in a cluster and its centroid. Considering any obvious outlier deviating from a smooth progression is important since the average distance naturally decreases as the number of clusters increases (<xref ref-type="bibr" rid="ref24">Hofmann and Klinkenberg, 2016</xref>).</p>
<p>The association rule was initially proposed by <xref ref-type="bibr" rid="ref1">Agrawal et al. (1993)</xref> for market basket analysis. Our study uses association rules to identify correlations and co-occurrences among several factors affecting human behavioral outcomes or student success. The aim is to explain patterns in data derived from independent information repositories.</p>
<p>Association rules (<italic>R</italic>) are expressed as &#x201C;if-then&#x201D; statements or <italic>X</italic>&#x202F;&#x2192;&#x202F;<italic>Y</italic>, where <italic>X</italic> and <italic>Y</italic> represent two sets of items. These rules are defined based on a set of transactions (<italic>T</italic>). Two measures are associated with association rules: <italic>support or sup</italic>(<italic>R</italic>) and confidence or <italic>conf</italic> (<italic>R</italic>). The support is the probability of <italic>X</italic> appearing in a transaction, while the confidence is the conditional probability of <italic>Y</italic> appearing when <italic>X</italic> is also present in a transaction (<xref ref-type="bibr" rid="ref36">Pei, 2009</xref>).</p><disp-formula id="E1">
<mml:math id="M1">
<mml:mi mathvariant="italic">Support</mml:mi>
<mml:mo>=</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:mi>f</mml:mi>
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<mml:mfenced open="(" close=")" separators=",">
<mml:mi>X</mml:mi>
<mml:mi>Y</mml:mi>
</mml:mfenced>
</mml:mrow>
<mml:mi>n</mml:mi>
</mml:mfrac>
</mml:math>
</disp-formula><disp-formula id="E2">
<mml:math id="M2">
<mml:mi mathvariant="italic">Confidence</mml:mi>
<mml:mo>=</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:mi>f</mml:mi>
<mml:mi>r</mml:mi>
<mml:mi>q</mml:mi>
<mml:mfenced open="(" close=")" separators=",">
<mml:mi>X</mml:mi>
<mml:mi>Y</mml:mi>
</mml:mfenced>
</mml:mrow>
<mml:mrow>
<mml:mi>f</mml:mi>
<mml:mi>r</mml:mi>
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<mml:mspace width="0.33em"/>
<mml:mfenced open="(" close=")">
<mml:mi>X</mml:mi>
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</mml:mfrac>
</mml:math>
</disp-formula><disp-formula id="E3">
<mml:math id="M3">
<mml:mi mathvariant="italic">Lift</mml:mi>
<mml:mo>=</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:mi mathvariant="italic">Support</mml:mi>
<mml:mspace width="0.33em"/>
</mml:mrow>
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<mml:mi mathvariant="italic">Supp</mml:mi>
<mml:mspace width="0.33em"/>
<mml:mi>X</mml:mi>
<mml:mo>&#x2217;</mml:mo>
<mml:mi mathvariant="italic">Supp</mml:mi>
<mml:mspace width="0.33em"/>
<mml:mi>Y</mml:mi>
</mml:mrow>
</mml:mfrac>
</mml:math>
</disp-formula>
<p>Frq, frequent; supp, support.</p>
</sec>
<sec id="sec10">
<title>Software</title>
<p>RapidMiner Studio 10.1.3, a well-known data mining tool, is efficiently available for both supervised and unsupervised analyses (<xref ref-type="bibr" rid="ref24">Hofmann and Klinkenberg, 2016</xref>; <xref ref-type="bibr" rid="ref29">KDnuggets, 2016</xref>).</p>
</sec>
</sec>
<sec id="sec11">
<title>Data gathering</title>
<p>Study population: a dataset of 145 medical students.</p>
<p>Attributes (study factors): a total of 13 attributes from four categorical and numerical data domains, as shown in <xref ref-type="table" rid="tab1">Table 1</xref>. All factors were selected based on their statistical and clinical relevance to our research outcomes from literature reviews.</p>
<p>Data preparation:</p><list list-type="bullet">
<list-item>
<p>Missing value: none</p>
</list-item>
<list-item>
<p>Remove correlated features: to mitigate the risk of confusing correlation with causation, features were selected based on a <italic>p</italic>-value threshold of &#x003C;0.20 or determined by clinical significance (<xref ref-type="bibr" rid="ref2">Akoglu, 2018</xref>).</p>
</list-item>
<list-item>
<p>Feature selection: backward stepwise optimization selection was applied to identify the most useful attribute for classifying examples, with a generation without improvement set at 1.</p>
</list-item>
</list>
</sec>
<sec id="sec12">
<title>Data mining analysis</title>
<p>
<list list-type="bullet">
<list-item>
<p>Logistic regression: prevalence ratios and adjusted prevalence ratios were calculated using univariate and multivariate logistic regression, with statistical significance determined by a <italic>p</italic>-value &#x003C;0.05.</p>
</list-item>
<list-item>
<p>Association rule: rules were identified based on strong support, confidence, and independence correlation, with a Lift value &#x003E;1.</p>
</list-item>
<list-item>
<p>Clustering analysis: the number of clusters was determined based on clinical significance and robust internal validation, enabling the extraction of meaningful knowledge and insights from each group.</p>
</list-item>
</list>
</p>
</sec>
<sec id="sec13">
<title>Prediction</title>
<p>Model training&#x2013;testing (internal validation)/deployment (external validation): further research with a new cohort is required to test the model using an independent sample, as our study&#x2019;s datasets are inadequate.</p>
</sec>
<sec sec-type="results" id="sec14">
<title>Results</title>
<sec id="sec15">
<title>Characteristics of the study population</title>
<p>A total of 145 students, including 72 men and 73 women, participated in this survey. The majority of the respondents belonged to the high-grade group, comprising 92 students (63.4%), and the average age of the participants was 27.4&#x202F;&#x00B1;&#x202F;3.1&#x202F;years. The majority of the students resided in metropolitan areas (79.3%) and had a commute time to school of less than 30&#x202F;min (72.4%), with an equal distribution of relationship statuses (<xref ref-type="table" rid="tab2">Table 2</xref>).</p>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption>
<p>Baseline characteristics and study factors of the population.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Characteristics</th>
<th align="center" valign="top">High-grade</th>
<th align="center" valign="top">Low-grade</th>
<th align="center" valign="top">Total (<italic>n</italic>&#x202F;=&#x202F;145)</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
</tr>
<tr>
<th/>
<th align="center" valign="top"><italic>n</italic> (%)</th>
<th align="center" valign="top"><italic>n</italic> (%)</th>
<th align="center" valign="top"><italic>n</italic> (%)</th>
<th/>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" colspan="4">Gender</td>
<td align="center" valign="top">0.562<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">44 (61.1%)</td>
<td align="center" valign="top">28 (38.9%)</td>
<td align="center" valign="top">72 (49.7%)</td>
<td rowspan="2"/>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">48 (65.8%)</td>
<td align="center" valign="top">25 (34.3%)</td>
<td align="center" valign="top">73 (50.3%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Age (years)</td>
<td align="center" valign="top">&#x003C;0.001<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">20&#x2013;24</td>
<td align="center" valign="top">29 (82.9%)</td>
<td align="center" valign="top">6 (17.1%)</td>
<td align="center" valign="top">35 (24.1%)</td>
<td rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">25&#x2013;29</td>
<td align="center" valign="top">48 (69.6%)</td>
<td align="center" valign="top">21 (30.4%)</td>
<td align="center" valign="top">69 (47.6%)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2265; 30</td>
<td align="center" valign="top">15 (36.6%)</td>
<td align="center" valign="top">26 (63.4%)</td>
<td align="center" valign="top">41 (28.3%)</td>
</tr>
<tr>
<td align="left" valign="top">mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="center" valign="top">26.6&#x202F;&#x00B1;&#x202F;2.9</td>
<td align="center" valign="top">28.9&#x202F;&#x00B1;&#x202F;3.0</td>
<td align="center" valign="top">27.4&#x202F;&#x00B1;&#x202F;3.1</td>
<td align="center" valign="top">&#x003C;0.001<sup>b</sup></td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">BMI (kg/m2)</td>
<td align="center" valign="top">0.088<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">&#x003C;&#x202F;18.5</td>
<td align="center" valign="top">54 (73.0%)</td>
<td align="center" valign="top">20 (27.0%)</td>
<td align="center" valign="top">74 (51.0%)</td>
<td rowspan="4"/>
</tr>
<tr>
<td align="left" valign="top">18.5&#x2013;22.9</td>
<td align="center" valign="top">30 (53.6%)</td>
<td align="center" valign="top">26 (46.4%)</td>
<td align="center" valign="top">56 (38.6%)</td>
</tr>
<tr>
<td align="left" valign="top">23&#x2013;24.9</td>
<td align="center" valign="top">5 (62.5%)</td>
<td align="center" valign="top">3 (37.5%)</td>
<td align="center" valign="top">8 (5.5%)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2265;&#x202F;25</td>
<td align="center" valign="top">3 (42.9%)</td>
<td align="center" valign="top">4 (57.1%)</td>
<td align="center" valign="top">7 (4.8%)</td>
</tr>
<tr>
<td align="left" valign="top">mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="center" valign="top">18.4&#x202F;&#x00B1;&#x202F;3.0</td>
<td align="center" valign="top">19.6&#x202F;&#x00B1;&#x202F;3.4</td>
<td align="center" valign="top">18.8&#x202F;&#x00B1;&#x202F;3.2</td>
<td align="center" valign="top">0.038<sup>b</sup></td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">GPAX (Pre-medical school)</td>
<td align="center" valign="top">0.030<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">&#x003C;3.5</td>
<td align="center" valign="top">8 (38.1%)</td>
<td align="center" valign="top">13 (61.9%)</td>
<td align="center" valign="top">21 (14.5%)</td>
<td rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">3.5&#x2013;3.75</td>
<td align="center" valign="top">20 (64.5%)</td>
<td align="center" valign="top">11 (35.5%)</td>
<td align="center" valign="top">31 (21.4%)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2265; 3.75</td>
<td align="center" valign="top">64 (68.8%)</td>
<td align="center" valign="top">29 (31.2%)</td>
<td align="center" valign="top">93 (64.1%)</td>
</tr>
<tr>
<td align="left" valign="top">mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="center" valign="top">3.78&#x202F;&#x00B1;&#x202F;0.20</td>
<td align="center" valign="top">3.62&#x202F;&#x00B1;&#x202F;0.38</td>
<td align="center" valign="top">3.72&#x202F;&#x00B1;&#x202F;0.29</td>
<td align="center" valign="top">0.001<sup>b</sup></td>
</tr>
<tr>
<td align="left" valign="top">Graduated interval (year) (mean&#x202F;&#x00B1;&#x202F;SD)</td>
<td align="center" valign="top">2.9&#x202F;&#x00B1;&#x202F;3.0</td>
<td align="center" valign="top">4.7&#x202F;&#x00B1;&#x202F;2.7</td>
<td align="center" valign="top">3.5&#x202F;&#x00B1;&#x202F;3.0</td>
<td align="center" valign="top">&#x003C;0.001<sup>b</sup></td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Course of study (Year of session) (mean&#x202F;&#x00B1;&#x202F;SD)</td>
<td align="center" valign="top">0.631<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Session 1 (less than 3&#x202F;years)</td>
<td align="center" valign="top">40 (65.6%)</td>
<td align="center" valign="top">21 (34.3%)</td>
<td align="center" valign="top">61 (42.1%)</td>
<td rowspan="4"/>
</tr>
<tr>
<td align="left" valign="top">Session 2 (4&#x2013;5&#x202F;years)</td>
<td align="center" valign="top">16 (57.1%)</td>
<td align="center" valign="top">12 (42.9%)</td>
<td align="center" valign="top">28 (19.3%)</td>
</tr>
<tr>
<td align="left" valign="top">Session 3 (6&#x2013;8&#x202F;years)</td>
<td align="center" valign="top">24 (60.0%)</td>
<td align="center" valign="top">16 (40.0%)</td>
<td align="center" valign="top">40 (27.6%)</td>
</tr>
<tr>
<td align="left" valign="top">Session 4 (more than 8&#x202F;years)</td>
<td align="center" valign="top">12 (75.0%)</td>
<td align="center" valign="top">4 (25.0%)</td>
<td align="center" valign="top">16 (11%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Relationship status</td>
<td align="center" valign="top">0.501<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Single</td>
<td align="center" valign="top">47 (66.2%)</td>
<td align="center" valign="top">24 (33.8%)</td>
<td align="center" valign="top">71 (49%)</td>
<td rowspan="2"/>
</tr>
<tr>
<td align="left" valign="top">Dating</td>
<td align="center" valign="top">45 (60.8%)</td>
<td align="center" valign="top">29 (39.2%)</td>
<td align="center" valign="top">74 (51%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Family address</td>
<td align="center" valign="top">0.196<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Metropolis</td>
<td align="center" valign="top">16 (53.3%)</td>
<td align="center" valign="top">14 (46.7%)</td>
<td align="center" valign="top">115 (79.3%)</td>
<td rowspan="2"/>
</tr>
<tr>
<td align="left" valign="top">Others</td>
<td align="center" valign="top">76 (66.1%)</td>
<td align="center" valign="top">39 (33.9%)</td>
<td align="center" valign="top">30 (20.7%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Transportation time to school (min)</td>
<td align="center" valign="top">0.016<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Less than 30&#x202F;min.</td>
<td align="center" valign="top">74 (70.5%)</td>
<td align="center" valign="top">31 (29.5%)</td>
<td align="center" valign="top">105 (72.4%)</td>
<td rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">30 to 60&#x202F;min.</td>
<td align="center" valign="top">13 (43.4%)</td>
<td align="center" valign="top">17 (56.7%)</td>
<td align="center" valign="top">30 (20.7%)</td>
</tr>
<tr>
<td align="left" valign="top">More than 60&#x202F;min.</td>
<td align="center" valign="top">5 (50.0%)</td>
<td align="center" valign="top">5 (50%)</td>
<td align="center" valign="top">10 (6.9%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Family income (Thai Baht per month)</td>
<td align="center" valign="top">0.588<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Less than 20,000</td>
<td align="center" valign="top">5 (71.4%)</td>
<td align="center" valign="top">2 (28.6%)</td>
<td align="center" valign="top">7 (4.8%)</td>
<td rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">20,000&#x2013;1000,000</td>
<td align="center" valign="top">58 (65.9%)</td>
<td align="center" valign="top">30 (34.1%)</td>
<td align="center" valign="top">88 (60.7%)</td>
</tr>
<tr>
<td align="left" valign="top">More than 100,000</td>
<td align="center" valign="top">29 (58.0%)</td>
<td align="center" valign="top">21 (42.0%)</td>
<td align="center" valign="top">50 (34.5%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Learning resources</td>
<td align="center" valign="top">0.349<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Internet Wi-Fi</td>
<td align="center" valign="top">3 (100.0%)</td>
<td align="center" valign="top">0 (0%)</td>
<td align="center" valign="top">3 (2.1%)</td>
<td rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">Internet Computer</td>
<td align="center" valign="top">6 (54.5%)</td>
<td align="center" valign="top">5 (45.5%)</td>
<td align="center" valign="top">11 (7.6%)</td>
</tr>
<tr>
<td align="left" valign="top">Internet Computer iPad</td>
<td align="center" valign="top">83 (63.4%)</td>
<td align="center" valign="top">48 (36.6%)</td>
<td align="center" valign="top">131 (90.3%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Online learning attendance (% of total in class/clinic)</td>
<td align="center" valign="top">0.628<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Hybrid to complete online</td>
<td align="center" valign="top">52 (69.3%)</td>
<td align="center" valign="top">23 (30.7%)</td>
<td align="center" valign="top">75 (51.7%)</td>
<td rowspan="2"/>
</tr>
<tr>
<td align="left" valign="top">No online learning</td>
<td align="center" valign="top">40 (57.1%)</td>
<td align="center" valign="top">30 (42.9%)</td>
<td align="center" valign="top">70 (48.3%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Specialties of interest</td>
<td align="center" valign="top">&#x003C;0.001<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Internal medicine</td>
<td align="center" valign="top">32 (91.4%)</td>
<td align="center" valign="top">3 (8.6%)</td>
<td align="center" valign="top">35 (30.4%)</td>
<td rowspan="5"/>
</tr>
<tr>
<td align="left" valign="top">Obstetrics &#x0026; Gynecology</td>
<td align="center" valign="top">9 (45.0%)</td>
<td align="center" valign="top">11 (55.0%)</td>
<td align="center" valign="top">20 (15.4%)</td>
</tr>
<tr>
<td align="left" valign="top">Surgery</td>
<td align="center" valign="top">11 (64.7%)</td>
<td align="center" valign="top">6 (35.3%)</td>
<td align="center" valign="top">17 (12.8%)</td>
</tr>
<tr>
<td align="left" valign="top">Pediatrics</td>
<td align="center" valign="top">10 (76.9%)</td>
<td align="center" valign="top">3 (23.1%)</td>
<td align="center" valign="top">13 (9.5%)</td>
</tr>
<tr>
<td align="left" valign="top">Others</td>
<td align="center" valign="top">30 (50.0%)</td>
<td align="center" valign="top">30 (50%)</td>
<td align="center" valign="top">60 (31.9%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Time for study (per day)</td>
<td align="center" valign="top">0.782<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Less than 1&#x202F;h</td>
<td align="center" valign="top">42 (61.8%)</td>
<td align="center" valign="top">26 (38.2%)</td>
<td align="center" valign="top">68 (46.9%)</td>
<td rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">1&#x2013;2&#x202F;h</td>
<td align="center" valign="top">42 (63.6%)</td>
<td align="center" valign="top">24 (36.4%)</td>
<td align="center" valign="top">66 (45.5%)</td>
</tr>
<tr>
<td align="left" valign="top">More than 2&#x202F;h</td>
<td align="center" valign="top">8 (72.7%)</td>
<td align="center" valign="top">3 (27.3%)</td>
<td align="center" valign="top">11 (7.6%)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="4">Learning style</td>
<td align="center" valign="top">0.964<sup>a</sup></td>
</tr>
<tr>
<td align="left" valign="top">Visual</td>
<td align="center" valign="top">21 (60.0%)</td>
<td align="center" valign="top">14 (40%)</td>
<td align="center" valign="top">35 (24.1%)</td>
<td rowspan="5"/>
</tr>
<tr>
<td align="left" valign="top">Auditory</td>
<td align="center" valign="top">15 (62.5%)</td>
<td align="center" valign="top">9 (37.5%)</td>
<td align="center" valign="top">24 (16.6%)</td>
</tr>
<tr>
<td align="left" valign="top">Reading</td>
<td align="center" valign="top">8 (61.5%)</td>
<td align="center" valign="top">5 (38.5%)</td>
<td align="center" valign="top">13 (9%)</td>
</tr>
<tr>
<td align="left" valign="top">Kinesthetics</td>
<td align="center" valign="top">34 (64.2%)</td>
<td align="center" valign="top">19 (35.8%)</td>
<td align="center" valign="top">53 (36.6%)</td>
</tr>
<tr>
<td align="left" valign="top">Mixed</td>
<td align="center" valign="top">14 (70.0%)</td>
<td align="center" valign="top">6 (30.0%)</td>
<td align="center" valign="top">20 (13.7%)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>SD, Standard Deviation; BMI, body mass index; GPAX, accumulated grade point average; THB, Thai Baht.</p>
<p><sup>achi-square test.</sup></p>
<p><sup>bt-test.</sup></p>
</table-wrap-foot>
</table-wrap>
<p>Baseline characteristic data between the two groups show significant differences in age, body mass index, and baseline GPAX (pre-med). The average age in the high-grade group was estimated to be 2&#x202F;years younger, indicating an earlier interval to graduation. However, when comparing educational course sessions, no differences were observed. Therefore, age or interval time was not considered an influential factor, and the course session was used for analysis instead.</p>
<p>While the overall sample&#x2019;s average BMI indicated underweight, the low-grade group exhibited a normal weight distribution, albeit slightly lower, nearing the borderline limit. Finally, the baseline pre-med GPAX was 4% lower in the low-grade group, with an average of 3.62 compared to 3.78 in the high-grade group.</p>
<p>Furthermore, no differences were found between the two groups regarding gender, relationship status, family address, and income. Among the medical students, the predominant learning style was kinesthetic (36.3%), followed by visual, auditory, mixed, and reading. While there were differences in transportation time and specialties of interest, these will be further analyzed and presented below.</p>
<p>Logistic regression was primarily performed to identify influential factors for high-grade students. Univariate analysis revealed three significant factors: baseline GPAX (pre-med), transportation time, and specialties of interest. Backward-stepwise elimination was then used for factor selection, resulting in two significant factors, presented in <xref ref-type="table" rid="tab3">Table 3</xref>. A GPAX of &#x2265;3.75 in pre-medical school had an adjusted prevalence ratio (APR) of 1.73 (95% CI, 1.02&#x2013;2.91, <italic>p</italic>-value&#x202F;=&#x202F;0.040) for high-grade outcome. In contrast, an interest in internal medicine specialties had an APR of 1.52 (95% CI, 1.14&#x2013;2.03, <italic>p</italic>-value&#x202F;=&#x202F;0.005).</p>
<table-wrap position="float" id="tab3">
<label>Table 3</label>
<caption>
<p>Univariate and multivariate logistic regression analyses of the factors associated with student high GPAX.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Attributes</th>
<th align="center" valign="top">Total</th>
<th align="center" valign="top">High-grade</th>
<th align="center" valign="top" colspan="2">Univariable</th>
<th align="center" valign="top" colspan="2">Multivariable</th>
</tr>
<tr>
<th align="center" valign="top"><italic>n</italic> (%)</th>
<th align="center" valign="top"><italic>n</italic> (%)</th>
<th align="center" valign="top">PR (95%CI)</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
<th align="center" valign="top">APR (95%CI)</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" colspan="7">Sex</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">72 (49.7%)</td>
<td align="center" valign="top">44 (61.1%)</td>
<td align="center" valign="top">1</td>
<td/>
<td align="center" valign="top">1</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">73 (50.3%)</td>
<td align="center" valign="top">48 (65.8%)</td>
<td align="center" valign="top">1.08 (0.84&#x2013;1.38)</td>
<td align="center" valign="top">0.562</td>
<td align="center" valign="top">1.13 (0.90&#x2013;1.42)</td>
<td align="center" valign="top">0.278</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">BMI (kg/m2)</td>
</tr>
<tr>
<td align="left" valign="top">18.5&#x2013;22.9</td>
<td align="center" valign="top">56 (38.6%)</td>
<td align="center" valign="top">30 (53.6%)</td>
<td align="center" valign="top">1</td>
<td align="center" valign="top">1</td>
<td colspan="2" rowspan="4"/>
</tr>
<tr>
<td align="left" valign="top">&#x003C;&#x202F;18.5</td>
<td align="center" valign="top">74 (51%)</td>
<td align="center" valign="top">54 (73.0%)</td>
<td align="center" valign="top">1.36 (1.03&#x2013;1.80)</td>
<td align="center" valign="top">0.031</td>
</tr>
<tr>
<td align="left" valign="top">23&#x2013;24.9</td>
<td align="center" valign="top">8 (5.5%)</td>
<td align="center" valign="top">5 (62.5%)</td>
<td align="center" valign="top">1.17 (0.65&#x2013;2.10)</td>
<td align="center" valign="top">0.608</td>
</tr>
<tr>
<td align="left" valign="top">&#x2265;&#x202F;25</td>
<td align="center" valign="top">7 (4.8%)</td>
<td align="center" valign="top">3 (42.9%)</td>
<td align="center" valign="top">0.80 (0.33&#x2013;1.95)</td>
<td align="center" valign="top">0.623</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">GPAX (Pre-medical school)</td>
</tr>
<tr>
<td align="left" valign="top">&#x003C;3.5</td>
<td align="center" valign="top">21 (14.5%)</td>
<td align="center" valign="top">8 (38.1%)</td>
<td align="center" valign="top">1</td>
<td/>
<td align="center" valign="top">1</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">3.5&#x2013;3.75</td>
<td align="center" valign="top">31 (21.4%)</td>
<td align="center" valign="top">20 (64.5%)</td>
<td align="center" valign="top">1.69 (0.92&#x2013;3.10)</td>
<td align="center" valign="top">0.088</td>
<td align="center" valign="top">1.69 (0.98&#x2013;2.91)</td>
<td align="center" valign="top">0.058</td>
</tr>
<tr>
<td align="left" valign="top">&#x2265; 3.75</td>
<td align="center" valign="top">93 (64.1%)</td>
<td align="center" valign="top">64 (68.8%)</td>
<td align="center" valign="top">1.81 (1.03&#x2013;3.17)</td>
<td align="center" valign="top">0.039</td>
<td align="center" valign="top">1.73 (1.02&#x2013;2.91)</td>
<td align="center" valign="top">0.040</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Course session (Graduated interval - year)</td>
</tr>
<tr>
<td align="left" valign="top">Session 1 (less than 3&#x202F;years)</td>
<td align="center" valign="top">61 (42.1%)</td>
<td align="center" valign="top">40 (65.6%)</td>
<td align="center" valign="top">1</td>
<td/>
<td align="center" valign="top">1</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">Session 2 (4&#x2013;5&#x202F;years)</td>
<td align="center" valign="top">28 (19.3%)</td>
<td align="center" valign="top">16 (57.1%)</td>
<td align="center" valign="top">0.87 (0.60&#x2013;1.26)</td>
<td align="center" valign="top">0.464</td>
<td align="center" valign="top">0.61 (0.34&#x2013;1.11)</td>
<td align="center" valign="top">0.108</td>
</tr>
<tr>
<td align="left" valign="top">Session 3 (6&#x2013;8&#x202F;years)</td>
<td align="center" valign="top">40 (27.6%)</td>
<td align="center" valign="top">24 (60.0%)</td>
<td align="center" valign="top">0.92 (0.67&#x2013;1.25)</td>
<td align="center" valign="top">0.576</td>
<td align="center" valign="top">0.70 (0.40&#x2013;1.22)</td>
<td align="center" valign="top">0.206</td>
</tr>
<tr>
<td align="left" valign="top">Session 4 (more than 8&#x202F;years)</td>
<td align="center" valign="top">16 (11%)</td>
<td align="center" valign="top">12 (75.0%)</td>
<td align="center" valign="top">1.14 (0.82&#x2013;1.60)</td>
<td align="center" valign="top">0.434</td>
<td align="center" valign="top">0.96 (0.57&#x2013;1.61)</td>
<td align="center" valign="top">0.865</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Relationship status</td>
</tr>
<tr>
<td align="left" valign="top">Single</td>
<td align="center" valign="top">71 (49%)</td>
<td align="center" valign="top">47 (66.2%)</td>
<td align="center" valign="top">1</td>
<td colspan="3"/>
</tr>
<tr>
<td align="left" valign="top">Dating</td>
<td align="center" valign="top">74 (51%)</td>
<td align="center" valign="top">45 (60.8%)</td>
<td align="center" valign="top">0.92 (0.72&#x2013;1.18)</td>
<td align="center" valign="top">0.501</td>
<td colspan="2"/>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Family address</td>
</tr>
<tr>
<td align="left" valign="top">Metropolis</td>
<td align="center" valign="top">115 (79.3%)</td>
<td align="center" valign="top">16 (53.3%)</td>
<td align="center" valign="top">1</td>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">Others</td>
<td align="center" valign="top">30 (20.7%)</td>
<td align="center" valign="top">76 (66.1%)</td>
<td align="center" valign="top">1.24 (0.87&#x2013;1.78)</td>
<td align="center" valign="top">0.242</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Transportation time (min)</td>
</tr>
<tr>
<td align="left" valign="top">Less than 30&#x202F;min.</td>
<td align="center" valign="top">105 (72.4%)</td>
<td align="center" valign="top">74 (70.5%)</td>
<td align="center" valign="top">1</td>
<td/>
<td align="center" valign="top">1</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">30 to 60&#x202F;min.</td>
<td align="center" valign="top">30 (20.7%)</td>
<td align="center" valign="top">13 (43.4%)</td>
<td align="center" valign="top">0.61 (0.40&#x2013;0.94)</td>
<td align="center" valign="top">0.026</td>
<td align="center" valign="top">0.74 (0.52&#x2013;1.04)</td>
<td align="center" valign="top">0.080</td>
</tr>
<tr>
<td align="left" valign="top">More than 60&#x202F;min.</td>
<td align="center" valign="top">10 (6.9%)</td>
<td align="center" valign="top">5 (50.0%)</td>
<td align="center" valign="top">0.71 (0.38&#x2013;1.33)</td>
<td align="center" valign="top">0.287</td>
<td align="center" valign="top">0.59 (0.30&#x2013;1.14)</td>
<td align="center" valign="top">0.118</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Family income (Thai Baht per month)</td>
</tr>
<tr>
<td align="left" valign="top">Less than 20,000</td>
<td align="center" valign="top">7 (4.8%)</td>
<td align="center" valign="top">5 (71.4%)</td>
<td align="center" valign="top">1</td>
<td/>
<td colspan="2" rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">20,000-1000,000</td>
<td align="center" valign="top">88 (60.7%)</td>
<td align="center" valign="top">58 (65.9%)</td>
<td align="center" valign="top">0.92 (0.56&#x2013;1.51)</td>
<td align="center" valign="top">0.749</td>
</tr>
<tr>
<td align="left" valign="top">More than 100,000</td>
<td align="center" valign="top">50 (34.5%)</td>
<td align="center" valign="top">29 (58.0%)</td>
<td align="center" valign="top">0.81 (0.48&#x2013;1.37)</td>
<td align="center" valign="top">0.436</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Learning resources</td>
</tr>
<tr>
<td align="left" valign="top">Internet Wi-Fi</td>
<td align="center" valign="top">3 (2.1%)</td>
<td align="center" valign="top">3 (100.0%)</td>
<td align="center" valign="top">1</td>
<td colspan="3"/>
</tr>
<tr>
<td align="left" valign="top">Internet Computer</td>
<td align="center" valign="top">11 (7.6%)</td>
<td align="center" valign="top">6 (54.5%)</td>
<td align="center" valign="top">0.69 (0.20&#x2013;2.40)</td>
<td align="center" valign="top">0.563</td>
<td colspan="2"/>
</tr>
<tr>
<td align="left" valign="top">Internet Computer iPad</td>
<td align="center" valign="top">131 (90.3%)</td>
<td align="center" valign="top">83 (63.4%)</td>
<td align="center" valign="top">1</td>
<td colspan="3"/>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Online learning attendance (% of total in class/ clinic)</td>
</tr>
<tr>
<td align="left" valign="top">Hybrid to complete online</td>
<td align="center" valign="top">75 (51.7%)</td>
<td align="center" valign="top">52 (69.3%)</td>
<td align="center" valign="top">1</td>
<td colspan="3"/>
</tr>
<tr>
<td align="left" valign="top">No online learning</td>
<td align="center" valign="top">70 (48.3%)</td>
<td align="center" valign="top">40 (57.1%)</td>
<td align="center" valign="top">1.07 (0.81&#x2013;1.42)</td>
<td align="center" valign="top">0.636</td>
<td colspan="2"/>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Specialties of interest</td>
</tr>
<tr>
<td align="left" valign="top">Minor</td>
<td align="center" valign="top">60 (31.9%)</td>
<td align="center" valign="top">30 (50.0%)</td>
<td align="center" valign="top">1</td>
<td/>
<td align="center" valign="top">1</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">Internal medicine</td>
<td align="center" valign="top">35 (30.4%)</td>
<td align="center" valign="top">32 (91.4%)</td>
<td align="center" valign="top">1.83 (1.39&#x2013;2.40)</td>
<td align="center" valign="top">&#x003C;0.001</td>
<td align="center" valign="top">1.52 (1.14&#x2013;2.03)</td>
<td align="center" valign="top">0.005</td>
</tr>
<tr>
<td align="left" valign="top">Obstetrics &#x0026; Gynecology</td>
<td align="center" valign="top">20 (15.4%)</td>
<td align="center" valign="top">9 (45.0%)</td>
<td align="center" valign="top">0.9 (0.52&#x2013;1.55)</td>
<td align="center" valign="top">0.706</td>
<td align="center" valign="top">0.54 (0.20&#x2013;1.49)</td>
<td align="center" valign="top">0.235</td>
</tr>
<tr>
<td align="left" valign="top">Surgery</td>
<td align="center" valign="top">17 (12.8%)</td>
<td align="center" valign="top">11 (64.7%)</td>
<td align="center" valign="top">1.29 (0.84&#x2013;1.99)</td>
<td align="center" valign="top">0.243</td>
<td align="center" valign="top">0.84 (0.34&#x2013;2.08)</td>
<td align="center" valign="top">0.709</td>
</tr>
<tr>
<td align="left" valign="top">Pediatrics</td>
<td align="center" valign="top">13 (9.5%)</td>
<td align="center" valign="top">10 (76.9%)</td>
<td align="center" valign="top">1.54 (1.04&#x2013;2.27)</td>
<td align="center" valign="top">0.031</td>
<td align="center" valign="top">0.98 (0.41&#x2013;2.33)</td>
<td align="center" valign="top">0.967</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Time for study (per day)</td>
</tr>
<tr>
<td align="left" valign="top">Less than 1&#x202F;h</td>
<td align="center" valign="top">68 (46.9%)</td>
<td align="center" valign="top">42 (61.8%)</td>
<td align="center" valign="top">1</td>
<td/>
<td colspan="2" rowspan="3"/>
</tr>
<tr>
<td align="left" valign="top">1&#x2013;2&#x202F;h</td>
<td align="center" valign="top">66 (45.5%)</td>
<td align="center" valign="top">42 (63.6%)</td>
<td align="center" valign="top">1.03 (0.79&#x2013;1.34)</td>
<td align="center" valign="top">0.823</td>
</tr>
<tr>
<td align="left" valign="top">More than 2&#x202F;h</td>
<td align="center" valign="top">11 (7.6%)</td>
<td align="center" valign="top">8 (72.7%)</td>
<td align="center" valign="top">1.18 (0.84&#x2013;1.99)</td>
<td align="center" valign="top">0.432</td>
</tr>
<tr>
<td align="left" valign="top" colspan="7">Learning style</td>
</tr>
<tr>
<td align="left" valign="top">Visual</td>
<td align="center" valign="top">35 (24.1%)</td>
<td align="center" valign="top">21 (60.0%)</td>
<td align="center" valign="top">1</td>
<td/>
<td align="center" valign="top">1</td>
<td/>
</tr>
<tr>
<td align="left" valign="top">Auditory</td>
<td align="center" valign="top">24 (16.6%)</td>
<td align="center" valign="top">15 (62.5%)</td>
<td align="center" valign="top">1.04 (0.69&#x2013;1.57)</td>
<td align="center" valign="top">0.846</td>
<td align="center" valign="top">1.06 (0.74&#x2013;1.52)</td>
<td align="center" valign="top">0.743</td>
</tr>
<tr>
<td align="left" valign="top">Reading</td>
<td align="center" valign="top">13 (9%)</td>
<td align="center" valign="top">8 (61.5%)</td>
<td align="center" valign="top">1.03 (0.62&#x2013;1.70)</td>
<td align="center" valign="top">0.922</td>
<td align="center" valign="top">1.06 (0.68&#x2013;1.67)</td>
<td align="center" valign="top">0.798</td>
</tr>
<tr>
<td align="left" valign="top">Kinetics</td>
<td align="center" valign="top">53 (36.6%)</td>
<td align="center" valign="top">34 (64.2%)</td>
<td align="center" valign="top">1.07 (0.76&#x2013;1.50)</td>
<td align="center" valign="top">0.697</td>
<td align="center" valign="top">1.03 (0.75&#x2013;1.41)</td>
<td align="center" valign="top">0.853</td>
</tr>
<tr>
<td align="left" valign="top">Mixed</td>
<td align="center" valign="top">20 (13.7%)</td>
<td align="center" valign="top">14 (70.0%)</td>
<td align="center" valign="top">1.17 (0.79&#x2013;1.73)</td>
<td align="center" valign="top">0.444</td>
<td align="center" valign="top">1.18 (0.84&#x2013;1.66)</td>
<td align="center" valign="top">0.348</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>PR; prevalence rate, APR; adjusted prevalence rate, CI; confidence interval, BMI; body mass index, GPAX; accumulated grade point average, THB; Thai Baht.</p>
</table-wrap-foot>
</table-wrap>
<p>Second, due to the hypothesis that multi-factors correlate with student outcomes, multidimensional data tools or unsupervised learning techniques were performed.</p>
<p>Cluster analysis was conducted using the k-Medoids algorithm, which was chosen for its capability to handle mixed data types (categorical and numerical) as required by our study. Clusters were generated from unlabeled data, with up to five clusters tested to optimize performance.</p>
<p>The optimal number of clusters was determined by evaluating the Davies-Bouldin (DB) index and the average within-centroid distance, aiming to achieve a balance between compactness within clusters and separation between clusters. The lowest DB index identified the optimal clustering structure, with two clusters achieving an acceptable balance of minimized within-cluster distance and maximized between-cluster distance. Based on these criteria, we selected and performed the analysis with two clusters, as shown in <xref ref-type="table" rid="tab4">Table 4</xref>.</p>
<table-wrap position="float" id="tab4">
<label>Table 4</label>
<caption>
<p>Performance evaluation of the optimal number of clusters.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Performance Vector<break/>Numbers of clusters</th>
<th align="center" valign="top">2</th>
<th align="center" valign="top">3</th>
<th align="center" valign="top">4</th>
<th align="center" valign="top">5</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Average within centroid distance:</td>
<td align="center" valign="top">1.844</td>
<td align="center" valign="top">1.572</td>
<td align="center" valign="top">1.413</td>
<td align="center" valign="top">1.255</td>
</tr>
<tr>
<td align="left" valign="top">Average within centroid distance_cluster_0:</td>
<td align="center" valign="top">1.595</td>
<td align="center" valign="top">1.468</td>
<td align="center" valign="top">1.229</td>
<td align="center" valign="top">1.163</td>
</tr>
<tr>
<td align="left" valign="top">Average within centroid distance_cluster_1:</td>
<td align="center" valign="top">1.967</td>
<td align="center" valign="top">1.221</td>
<td align="center" valign="top">1.221</td>
<td align="center" valign="top">1.058</td>
</tr>
<tr>
<td align="left" valign="top">Average within centroid distance_cluster_2:</td>
<td rowspan="3"/>
<td align="center" valign="top">1.776</td>
<td align="center" valign="top">1.229</td>
<td align="center" valign="top">1.221</td>
</tr>
<tr>
<td align="left" valign="top">Average within centroid distance_cluster_3:</td>
<td rowspan="2"/>
<td align="center" valign="top">1.674</td>
<td align="center" valign="top">1.602</td>
</tr>
<tr>
<td align="left" valign="top">Average within centroid distance_cluster_4:</td>
<td/>
<td align="center" valign="top">1.429</td>
</tr>
<tr>
<td align="left" valign="top">Davies Bouldin:</td>
<td align="center" valign="top">0.086</td>
<td align="center" valign="top">0.091</td>
<td align="center" valign="top">0.09</td>
<td align="center" valign="top">0.098</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>Study factors clustered into two groups, with detailed centroids shown in <xref ref-type="table" rid="tab5">Table 5</xref>. A graphical centroid plot and a heat map, emphasizing learning styles, are shown in <xref ref-type="fig" rid="fig3">Figures 3</xref>, <xref ref-type="fig" rid="fig4">4</xref>, respectively.</p>
<table-wrap position="float" id="tab5">
<label>Table 5</label>
<caption>
<p>Descriptive centroid table of cluster analysis.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Attributes</th>
<th align="center" valign="top">Description</th>
<th align="center" valign="top">Cluster 0</th>
<th align="center" valign="top">Cluster 1</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Gender</td>
<td align="center" valign="top">Female/male</td>
<td align="center" valign="top">Male</td>
<td align="center" valign="top">Male</td>
</tr>
<tr>
<td align="left" valign="top">Weight status</td>
<td align="center" valign="top">Underweight/</td>
<td align="center" valign="top">Underweight</td>
<td align="center" valign="top">Underweight</td>
</tr>
<tr>
<td align="left" valign="top">Session</td>
<td align="center" valign="top">1&#x2013;4</td>
<td align="center" valign="top">2</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Relationship</td>
<td align="center" valign="top">Dating/single</td>
<td align="center" valign="top">Single</td>
<td align="center" valign="top">Single</td>
</tr>
<tr>
<td align="left" valign="top">Home address</td>
<td align="center" valign="top">Metropolis/others</td>
<td align="center" valign="top">Metropolis</td>
<td align="center" valign="top">Others</td>
</tr>
<tr>
<td align="left" valign="top">Transportation time</td>
<td align="center" valign="top">Min/day</td>
<td align="center" valign="top">Less than 30&#x202F;min</td>
<td align="center" valign="top">Less than 30&#x202F;min</td>
</tr>
<tr>
<td align="left" valign="top">Family income</td>
<td align="center" valign="top">THB/day</td>
<td align="center" valign="top">Less than 20,000 THB</td>
<td align="center" valign="top">Less than 20,000 THB</td>
</tr>
<tr>
<td align="left" valign="top">Learning resources Wi-Fi to iPad</td>
<td align="center" valign="top">Internet Wi-Fi, computer, iPad</td>
<td align="center" valign="top">Internet Wi-Fi, computer</td>
<td align="center" valign="top">Internet Wi-Fi, computer</td>
</tr>
<tr>
<td align="left" valign="top">Online learning attendance is less than classroom</td>
<td align="center" valign="top">Online-Hybrid/Onsite-classroom</td>
<td align="center" valign="top">Hybrid</td>
<td align="center" valign="top">Hybrid</td>
</tr>
<tr>
<td align="left" valign="top">GPAX (Pre-medical school)</td>
<td/>
<td align="center" valign="top">3.98</td>
<td align="center" valign="top">3.89</td>
</tr>
<tr>
<td align="left" valign="top">GPAX (Medical school)</td>
<td/>
<td align="center" valign="top">3.67</td>
<td align="center" valign="top">3.01</td>
</tr>
<tr>
<td align="left" valign="top">Specialties of interest</td>
<td align="center" valign="top">Medicine/ OB-GYN/ Pediatrics/ Surgery/ Others</td>
<td align="center" valign="top">Others</td>
<td align="center" valign="top">Surgery</td>
</tr>
<tr>
<td align="left" valign="top">Time for study less to more</td>
<td align="center" valign="top">Min/ day</td>
<td align="center" valign="top">30&#x2013;60&#x202F;min</td>
<td align="center" valign="top">30&#x2013;60&#x202F;min</td>
</tr>
<tr>
<td align="left" valign="top">Point_V</td>
<td align="center" valign="top">Point 0&#x2013;16</td>
<td align="center" valign="top">2</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Point_A</td>
<td align="center" valign="top">Point 0&#x2013;16</td>
<td align="center" valign="top">1</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Point_R</td>
<td align="center" valign="top">Point 0&#x2013;16</td>
<td align="center" valign="top">5</td>
<td align="center" valign="top">5</td>
</tr>
<tr>
<td align="left" valign="top">Point_K</td>
<td align="center" valign="top">Point 0&#x2013;16</td>
<td align="center" valign="top">8</td>
<td align="center" valign="top">3</td>
</tr>
<tr>
<td align="left" valign="top">Conclusion VARK</td>
<td align="center" valign="top">VARK</td>
<td align="center" valign="top">K</td>
<td align="center" valign="top">K</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>V, visual; A, auditory; R, reading; K, kinesthetics.</p>
</table-wrap-foot>
</table-wrap>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption>
<p>Centroid plot of cluster analysis for all attributes. Created by RapidMiner Studio 10.1.3.</p>
</caption>
<graphic xlink:href="feduc-09-1390892-g003.tif"/>
</fig>
<fig position="float" id="fig4">
<label>Figure 4</label>
<caption>
<p>Heat map of cluster analysis of learning style. Created by RapidMiner Studio 10.1.3.</p>
</caption>
<graphic xlink:href="feduc-09-1390892-g004.tif"/>
</fig>
<p>Cluster 0 (<italic>n</italic>&#x202F;=&#x202F;48) has a smaller population, estimated to be one-third of the students. These students tended to perform at a high-grade level (GPAX&#x202F;=&#x202F;3.67) and had home addresses in metropolis areas. Their baseline pre-med GPAX was higher (3.98), and their preferred learning style was kinesthetic (score&#x202F;=&#x202F;8).</p>
<p>Cluster 1 (<italic>n</italic>&#x202F;=&#x202F;97) was the largest, consisting of students who graduated earlier (session 1). Their academic performance fell within the low-grade range of the study (GPAX&#x202F;=&#x202F;3.01), while their pre-med GPAX was slightly lower (3.89). They had home addresses outside of metropolis areas and showed interest in the field of surgery. The predominant learning style was not specific, but the highest score was associated with reading.</p>
<p>A comparison of the two clusters focusing on learning styles, as illustrated by the heat map in <xref ref-type="fig" rid="fig4">Figure 4</xref>, reveals distinct associations between learning styles and performance across the two clusters. Cluster 0 (higher-grade students) shows a stronger preference for kinesthetic learning (Point_K) but lower scores in auditory and visual styles (Points_A and V). Although both clusters exhibit a similar preference for reading (Point_R), Cluster 1 (lower-grade students) demonstrates a slightly higher association with auditory learning.</p>
</sec>
<sec id="sec16">
<title>Association rule</title>
<p>From the association analysis, a total of 351 rules were generated. The selected rules, primarily screened based on lift (&#x003E;1, indicating a positive independent association), are presented in <xref ref-type="table" rid="tab6">Table 6</xref>. Lift is an important metric as it measures the strength of the relationship between the premise and the outcome, showing how much more likely the outcome is to occur when the premise holds true, compared to random chance. A lift greater than 1 indicates a meaningful positive association. The rule with the <italic>highest confidence</italic> was: {Metropolis address&#x202F;+&#x202F;transportation time less than 30&#x202F;min&#x202F;+&#x202F;underweight}&#x202F;&#x21D2;&#x202F;high-grade student, with a confidence of 0.81 and lift of 1.34, indicating that these factors increase the likelihood of achieving a high grade.</p>
<table-wrap position="float" id="tab6">
<label>Table 6</label>
<caption>
<p>Selected association rules involving high GPAX in medical students.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Premises</th>
<th align="left" valign="top">Conclusion</th>
<th align="center" valign="top">Support</th>
<th align="center" valign="top">Confidence</th>
<th align="center" valign="top">Lift</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" colspan="5">Confidence&#x202F;&#x003E;&#x202F;0.8</td>
</tr>
<tr>
<td align="left" valign="top">Home address_metropolis, Transportation time&#x202F;=&#x202F;Less than 30&#x202F;min., Weight status&#x202F;=&#x202F;Underweight</td>
<td align="left" valign="top">GPAX (MED)_High</td>
<td align="center" valign="top">0.27</td>
<td align="center" valign="top">0.81</td>
<td align="center" valign="top">1.34</td>
</tr>
<tr>
<td align="left" valign="top" colspan="5">Support&#x202F;&#x003E;&#x202F;0.3</td>
</tr>
<tr>
<td align="left" valign="top">Home address_metropolis, Transportation time&#x202F;=&#x202F;Less than 30&#x202F;min.</td>
<td align="left" valign="top">GPAX (MED)_High</td>
<td align="center" valign="top">0.41</td>
<td align="center" valign="top">0.76</td>
<td align="center" valign="top">1.25</td>
</tr>
<tr>
<td align="left" valign="top">Learning resources&#x202F;=&#x202F;Internet Computer iPad, Home address_metropolis, Transportation time&#x202F;=&#x202F;Less than 30&#x202F;min.</td>
<td align="left" valign="top">GPAX (MED)_High</td>
<td align="center" valign="top">0.37</td>
<td align="center" valign="top">0.75</td>
<td align="center" valign="top">1.23</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>The second rule, which had the <italic>highest support</italic> (indicating how frequently this combination of items appeared in the dataset), reinforced the first rule: {Metropolis address&#x202F;+&#x202F;transportation time less than 30&#x202F;min} &#x21D2; high-grade student, with a support of 0.41 and lift of 1.25. Additionally, a third rule, although with slightly <italic>lower support</italic>, introduced a new factor related to learning resources: {Learning resources (e.g., internet, computer, and iPad)&#x202F;+&#x202F;metropolis address&#x202F;+&#x202F;transportation time less than 30&#x202F;min}&#x202F;&#x21D2;&#x202F;high-grade student, with a support of 0.37 and lift of 1.23, highlighting the importance of access to educational tools.</p>
</sec>
</sec>
<sec sec-type="discussion" id="sec17">
<title>Discussion</title>
<p>Our study successfully employed logistic regression, cluster analysis, and association rules to identify factors affecting academic success among medical students, with a particular focus on visualization techniques; it is illustrated in a tree framework (<xref ref-type="fig" rid="fig5">Figure 5</xref>). Each method provided unique insights, enhancing our understanding of how academic, demographic, environmental, and psychological factors interact to shape student outcomes.</p>
<fig position="float" id="fig5">
<label>Figure 5</label>
<caption>
<p>Visual tree framework for influential factors in medical student success <bold>(A)</bold> Overview of the four main study domains: academic, demographic, environmental, and psychological factors. <bold>(B)</bold> Visual representation of the relationships between academic performance and key factors identified through logistic regression, cluster analysis, and association rules. APR, adjusted prevalence rate; DB index, Davies-Bouldin index.</p>
</caption>
<graphic xlink:href="feduc-09-1390892-g005.tif"/>
</fig>
<p>Logistic regression was applied to identify significant predictors of academic performance, with a pre-med GPAX of&#x202F;&#x2265;&#x202F;3.75 and an interest in internal medicine emerging as statistically significant factors associated with higher grades (APR 1.73, <italic>p</italic>&#x202F;=&#x202F;0.005; APR 1.52, <italic>p</italic>&#x202F;=&#x202F;0.040, respectively). Margins analysis also showed a predicted mean GPAX (med) of 3.41 (<italic>p</italic>&#x202F;&#x003C;&#x202F;0.005) for students with a pre-med GPAX of &#x2265;3.75. This finding aligns with previous research highlighting GPAX as a strong predictor of academic performance (<xref ref-type="bibr" rid="ref21">Furnham and Monsen, 2009</xref>; <xref ref-type="bibr" rid="ref27">Jacobparayil et al., 2022</xref>). While baseline GPAX is unchangeable, ongoing support and targeted interventions could benefit students with lower pre-med GPAX, emphasizing the need for early awareness and academic assistance. Additionally, motivation toward specialty choice was found to influence academic outcomes, with internal medicine showing a significant association. Strong correlations were observed between internal medicine and an intellectual, inquisitive, and &#x2018;investigative&#x2019; personality profile, as identified through a validated 140-item questionnaire in a cluster analysis study (<xref ref-type="bibr" rid="ref41">Sievert et al., 2016</xref>). This essentially suggests that the personality traits that draw students to internal medicine&#x2014;such as intellectual curiosity and a preference for investigation&#x2014;might also help them succeed in the cognitive assessments commonly used in medical education. This alignment could help explain why students interested in internal medicine tend to perform better academically. Similar associations between competitive specialties and academic performance have also been noted (<xref ref-type="bibr" rid="ref33">Mitsouras et al., 2019</xref>). This may also reflect a supply&#x2013;demand dynamic, where students motivated to pursue competitive fields with high academic standards work harder to achieve better grades. However, we recognize that personal preferences, experiences, and external factors can influence specialty choice and academic outcomes (<xref ref-type="bibr" rid="ref42">Soethout et al., 2008</xref>). The above findings positively show the important role of factors in &#x201C;academic activities.&#x201D; However, we found no statistical relevance to demographic, environmental, or psychological factors. Interestingly, the finding of irrelevance of learning style and high-grade students, referring to high-performing students, indicates that they may have different ways of learning. Similar results have been reported in studies involving dental and medical students, including a larger cohort of 600 medical students (<xref ref-type="bibr" rid="ref34">Mozaffari et al., 2020</xref>; <xref ref-type="bibr" rid="ref5">Almigbal, 2015</xref>). Notably, subgroup analysis found that 40% (14 in 35) of high-grade students who were interested in medicine had a K learning style and achieved high grades. Similarly, other studies conducted involving medical students from Thailand and Saudi Arabia have suggested that specific learning styles are associated with higher achievement. Those were sequential learning or logical sequencing patterns and visuality (<xref ref-type="bibr" rid="ref28">Jiraporncharoen et al., 2015</xref>; <xref ref-type="bibr" rid="ref3">Al Fhaid et al., 2022</xref>). These contrasting results highlight the need for teachers to recognize that &#x201C;everyone cannot be taught the same way&#x201D; when designing classroom interventions and environments (<xref ref-type="bibr" rid="ref40">Shakeri et al., 2022</xref>).</p>
<p>However, we acknowledge that focusing solely on these two factors might oversimplify the complexity of academic success, as other potential influences were excluded due to a lack of statistical significance. This limitation indicates the need for additional methods to capture multidimensional factors beyond simple predictive models.</p>
<p>Utilizing cluster analysis to address the limitations of LR, we employed cluster analysis on unlabeled data, grouping students based on shared characteristics without predefined academic performance labels. This exploratory approach allowed us to uncover patterns within each cluster and then observe performance trends. We could identify typical characteristics of the high-grade group, which included residing in a metropolis, achieving a very high GPAX during pre-med, and a strong preference for kinesthetic learning, followed by the reading learning style. While the first two factors are non-modifiable, the discovery of kinesthetic learning style as a key factor in high-grade success is noteworthy. In contrast to the lower grade group, various types with slightly higher reading styles but very low K-style were investigated. This revealed a very high-grade cluster (GPAX centroid of 3.67), and K-style might be an interesting key factor in its success. As medical programs require both knowledge and skill, we assume that students approach their learning through a combination of reading and hands-on learning to effectively prepare students for the medical curriculum and lead to an honors degree. This aligns with the concept that medicine is not solely about scientific knowledge but also knowledge-driven practice or kinesthetic skill (<xref ref-type="bibr" rid="ref17">De Camargo, and Jr. Coeli, 2006</xref>). However, this theory should be applied cautiously, as observational studies using questionnaire reports that study strategies based on VARK results showed no correlation with anatomy course outcomes (<xref ref-type="bibr" rid="ref26">Husmann and O'Loughlin, 2019</xref>).</p>
<p>Finally, association analysis discovered informative rules emphasizing the importance of transportation time to school and access to learning resources, highlighting the significance of institutional resources in facilitating student knowledge acquisition.</p>
<p>Exploring individual learning styles can empower students to understand their strengths and preferences, aligning with Howard Gardner&#x2019;s theory of multiple intelligences, which emphasizes that learners excel through different modalities (<xref ref-type="bibr" rid="ref19">Durie, 1997</xref>; <xref ref-type="bibr" rid="ref25">Hopper and Hurry, 2000</xref>). Recognizing one&#x2019;s learning style can encourage self-directed learning, as outlined in constructivist theories, where students actively build understanding through engagement with content and adapt to the academic environment (Vygotsky, Piaget&#x2019;s theories) (<xref ref-type="bibr" rid="ref11">Blake, 2008</xref>). Incorporating learning styles into lesson planning may enhance students&#x2019; ability to relate to and comprehend material, fostering deeper and faster practical application. This aligns with Kolb&#x2019;s experiential learning cycle, specifically the active experimentation phase, where learners apply new knowledge to real-world scenarios, cultivating skills for lifelong learning (<xref ref-type="bibr" rid="ref30">Kolb, 2014</xref>).</p>
<p>For Teachers: We advocate for a tailored, student-centered approach to address diverse learning needs.</p>
<p>Similar to colors, students possess unique &#x201C;hues&#x201D; or learning styles, and by recognizing these differences, educators can implement varied instructional strategies to support and actualize each student&#x2019;s potential. Howard Gardner&#x2019;s theory of multiple intelligences supports this perspective, encouraging instructors to pluralize their teaching and assessment methods, thereby enriching student learning by addressing multiple modalities (<xref ref-type="bibr" rid="ref19">Durie, 1997</xref>; <xref ref-type="bibr" rid="ref25">Hopper and Hurry, 2000</xref>). Teachers can make learning more effective and inclusive by investing time to understand each learner&#x2019;s style and implementing multi-modality instructional methods, from passive (reading, auditory lectures) to active (kinesthetic activities, simulations, and role-play).</p>
<p>Dale&#x2019;s Cone of Experience reinforces this approach, demonstrating that hands-on and participatory methods often lead to better retention and understanding (<xref ref-type="bibr" rid="ref15">Dale, 1969</xref>; <xref ref-type="bibr" rid="ref7">Amin and Khoo, 2003</xref>). This strategy aligns with constructivist and humanistic theories, which emphasize active, collaborative, and context-rich learning for self-actualization. For example, problem-based learning (PBL) encourages students to engage in real-world problem-solving, deepening their understanding. Humanistic theories also advocate for a nurturing environment that fosters personal development and self-determination, underscoring the importance of adaptive, flexible teaching strategies (<xref ref-type="bibr" rid="ref11">Blake, 2008</xref>; <xref ref-type="bibr" rid="ref12">Brockett, 1996</xref>). Additionally, connectivism suggests that students in the digital age benefit from continually updating knowledge and connecting new and existing information, making a pluralistic approach even more relevant (<xref ref-type="bibr" rid="ref18">Duke et al., 2013</xref>).</p>
<p>Finally, institutions are pivotal in supporting student success by modifying environmental factors. Reducing transportation time and enhancing access to learning resources, such as digital tools and quiet study spaces, can positively impact academic outcomes. Maslow&#x2019;s hierarchy of needs suggests that meeting students&#x2019; basic needs (e.g., safe and accessible study environments) can facilitate higher-order achievements such as academic success. This aligns with humanistic theory, which highlights the role of a supportive and nurturing environment in fostering learning. When students have access to essential resources, they are more likely to engage fully with their studies, potentially achieving self-actualization as lifelong learners (<xref ref-type="bibr" rid="ref12">Brockett, 1996</xref>).</p>
<p>The strength of our study lies in the introduction of two unique analytical techniques&#x2014;logistic regression and data mining&#x2014;which enabled us to identify both statistically significant factors and meaningful hidden patterns. To the best of our knowledge, this is the first research to use multidomain factors to investigate medical students&#x2019; academic success, analyzing them with these techniques and emphasizing visualization.</p>
<p>Our study has several limitations. As a retrospective study relying on medical students&#x2019; recollections of experiences, recall bias may be present. We sought to reduce this by limiting the number of recall questions, focusing on specific periods within the 6-year medical program to improve accuracy. Additionally, reliance on self-reported data introduces potential recall and social desirability biases. To mitigate recall bias, we designed clear and specific questions, especially for demographic and environmental factors, and pre-tested the questionnaire to enhance reliability. To reduce social desirability bias, we assured participants of confidentiality and included disclaimers to encourage honesty. Another limitation relates to our sample composition. The study&#x2019;s focus and title may have attracted high-achieving students, potentially skewing the prevalence of high GPAX students in our sample and impacting representativeness. However, as our primary objective was to examine associations between factors, we believe this limitation only minimally affects the findings. Another limitation that could confound the outcome was the variation of students&#x2019; graduation years and other uncontrolled external factors such as scoring, teamwork, or health issues. However, multivariate analysis using a session period as a training course was believed to eliminate one confounder. Noteworthy that our populations might not truly represent the general medical student population, and further research is planned to investigate different universities and regions of the country. Future research may benefit from larger, more diverse datasets to enhance robustness and enable external validation, supporting broader generalizability. Additionally, advanced methods like hierarchical clustering and SVMs could uncover nuanced patterns and complex relationships, providing further insights for educational programs and decision-making.</p>
</sec>
<sec sec-type="conclusions" id="sec18">
<title>Conclusion</title>
<p>By utilizing three analytical methods, we identified key factors influencing medical students&#x2019; academic success. Logistic regression highlighted pre-med GPAX and an interest in internal medicine as significant predictors. Cluster analysis revealed distinct learning style patterns, with high-grade students favoring kinesthetic and reading styles, while lower-grade students preferred auditory and visual styles. Association rules emphasized the role of environmental factors, such as proximity to school and access to resources, in supporting academic outcomes. Together, these findings underscore the importance of a holistic approach in educational planning that considers learning preferences, personal interests, and supportive environments.</p>
<p>In summary, a multi-domain framework in educational planning can foster more effective and personalized learning experiences. By addressing individual learning styles, adaptive teaching strategies, and supportive environments, institutions can better equip medical students to achieve their academic and professional goals.</p>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="sec19">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec sec-type="ethics-statement" id="sec20">
<title>Ethics statement</title>
<p>The studies involving humans were approved by the Royal Thai Army Medical Department Institutional Review Board. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.</p>
</sec>
<sec sec-type="author-contributions" id="sec21">
<title>Author contributions</title>
<p>PR: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. CT: Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing, Methodology, Project administration. BS: Writing &#x2013; review &#x0026; editing. AP: Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec sec-type="funding-information" id="sec22">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<ack>
<p>The authors express their sincere gratitude to Akara, Boonsub, and Chulaluck for their contributions to the study design, hypothesis development, data interpretation, and manuscript revision. Additionally, we thank the Department of Obstetrics and Gynecology, Phramongkutklao College of Medicine, for their support in completing this study and acknowledge RapidMiner Studio 10.1.3 as the data mining tool. Special thanks to Dr. Molly for her warmhearted support and invaluable guidance during challenging times.</p>
</ack>
<sec sec-type="COI-statement" id="sec23">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="sec24">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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