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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Educ.</journal-id>
<journal-title>Frontiers in Education</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Educ.</abbrev-journal-title>
<issn pub-type="epub">2504-284X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">756907</article-id>
<article-id pub-id-type="doi">10.3389/feduc.2021.756907</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Education</subject>
<subj-group>
<subject>Brief Research Report</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Student&#x2019;s Perspectives on Augmented Reality in Pharmacy Education in Hong Kong</article-title>
<alt-title alt-title-type="left-running-head">Li et&#x20;al.</alt-title>
<alt-title alt-title-type="right-running-head">Augmented Reality in Pharmacy Education</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Li</surname>
<given-names>Joyce Tik Sze</given-names>
</name>
<uri xlink:href="https://loop.frontiersin.org/people/1165177/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ng</surname>
<given-names>Enoch E Nok</given-names>
</name>
<uri xlink:href="https://loop.frontiersin.org/people/1187802/overview"/>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Lee</surname>
<given-names>Vivian Wing Yan</given-names>
</name>
<xref ref-type="corresp" rid="c001">&#x2a;</xref>
<uri xlink:href="https://loop.frontiersin.org/people/518425/overview"/>
</contrib>
</contrib-group>
<aff>Centre for Learning Enhancement And Research, The Chinese University of Hong Kong, <addr-line>Hong Kong</addr-line> <addr-line>SAR</addr-line>, <country>China</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>
<bold>Edited by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/57822/overview">Fabrizio Consorti</ext-link>, Sapienza University of Rome, Italy</p>
</fn>
<fn fn-type="edited-by">
<p>
<bold>Reviewed by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/183231/overview">Adamantios Koumpis</ext-link>, University of Passau, Germany</p>
<p>
<ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1474156/overview">Oscar Tamburis</ext-link>, University of Naples Federico II, Italy</p>
</fn>
<corresp id="c001">&#x2a;Correspondence: Vivian Wing Yan Lee, <email>vivianlee@cuhk.edu.hk</email>
</corresp>
<fn fn-type="other">
<p>This article was submitted to Digital Education, a section of the journal Frontiers in Education</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>21</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="collection">
<year>2021</year>
</pub-date>
<volume>6</volume>
<elocation-id>756907</elocation-id>
<history>
<date date-type="received">
<day>11</day>
<month>08</month>
<year>2021</year>
</date>
<date date-type="accepted">
<day>06</day>
<month>10</month>
<year>2021</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2021 Li, Ng and Lee.</copyright-statement>
<copyright-year>2021</copyright-year>
<copyright-holder>Li, Ng and Lee</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these&#x20;terms.</p>
</license>
</permissions>
<abstract>
<p>
<bold>Introduction:</bold> Augmented reality (AR) technology has demonstrated potential on various areas of healthcare practice. Its role on medical education is starting to emerge. This study aimed to investigate students&#x2019; perspectives on using AR as learning tools in undergraduate pharmacy education.</p>
<p>
<bold>Methods:</bold> Four AR micro modules on post-stroke management and chronic obstructive pulmonary disease (COPD) were developed for third year undergraduate pharmacy students to study. Students played the role of pharmacists in the AR micro modules. They collected information to identify patient&#x2019;s chief complaints, history, risk factors, comorbidities, and other problems, and provided recommendation on patient&#x2019;s treatment plans. Teacher guided the discussions and addressed student&#x2019;s enquiries. Student&#x2019;s feedback was collected by pre- and post-intervention survey.</p>
<p>
<bold>Results:</bold> A total of 54 students participated in the current study. The was no significant change in students&#x2019; perceived knowledge on post-stroke management and COPD, as well as their confidence in providing patient counselling on relevant topics. Students expressed that their learning experience with AR was not positive. Technical problems were the major difficulties that students encountered.</p>
<p>
<bold>Conclusion:</bold> There was no significant difference in pharmacy students perceived clinical knowledge and confidence on patient&#x2019;s counselling after completing the AR modules. Technical issues were the major hurdles that hindered student&#x2019;s learning experience with&#x20;AR.</p>
</abstract>
<kwd-group>
<kwd>pharmacy education</kwd>
<kwd>augmented reality</kwd>
<kwd>pedagogy</kwd>
<kwd>active learning</kwd>
<kwd>practice experience</kwd>
</kwd-group>
<contract-sponsor id="cn001">Chinese University of Hong Kong<named-content content-type="fundref-id">10.13039/501100004853</named-content>
</contract-sponsor>
</article-meta>
</front>
<body>
<sec id="s1">
<title>Introduction</title>
<p>As future healthcare professionals, pharmacy students must be equipped with knowledge and skills to provide patient-centred care in a team-based approach. (<xref ref-type="bibr" rid="B60">Zgheib et&#x20;al., 2010</xref>; <xref ref-type="bibr" rid="B28">Miller et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B20">Lang et&#x20;al., 2019</xref>) The Accreditation Council for Pharmacy Education emphasizes that pharmacy programs provide students with the knowledge, skills, and abilities to provide patient-centred care and solve problems. (<xref ref-type="bibr" rid="B1">Accreditation Council for Pharmacy Education, 2015</xref>) Practice experience is essential for students to polish their communication skills and problem-solving skills. (<xref ref-type="bibr" rid="B52">Svensberg et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B53">Teramachi et&#x20;al., 2018</xref>) Nevertheless, actual practice experience could be influenced by numerous factors, such as the availability of clinical sites, patient cases, and teaching staff. (<xref ref-type="bibr" rid="B58">Wartman, 2019</xref>; <xref ref-type="bibr" rid="B45">Shrestha et&#x20;al., 2020</xref>) As information technology and communication technology advances, it is suggested that the challenges could be overcome by using simulated cases. (<xref ref-type="bibr" rid="B34">Okuda et&#x20;al., 2009</xref>; <xref ref-type="bibr" rid="B37">Ray et&#x20;al., 2012</xref>; <xref ref-type="bibr" rid="B44">Shin et&#x20;al., 2015</xref>)</p>
<p>In recent years, augmented reality (AR) has demonstrated potential on various aspects in the medical field, including diagnosis, assessment, and treatment. (<xref ref-type="bibr" rid="B14">Freeman et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B21">Laver et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B39">Rothgangel et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B8">Chen et&#x20;al., 2019</xref>; <xref ref-type="bibr" rid="B12">Feng et&#x20;al., 2019</xref>) AR is an enhanced version of the real physical world that is achieved through the use of digital visual elements, sound, or other sensory stimuli delivered via technology. (<xref ref-type="bibr" rid="B17">Investopedia, 2020</xref>) One advantage of AR in medical education is the ability to visualize body tissues, for example, the skin, organs and muscles. (<xref ref-type="bibr" rid="B42">Sayadi et&#x20;al., 2019</xref>; <xref ref-type="bibr" rid="B59">Yu et&#x20;al., 2019</xref>; <xref ref-type="bibr" rid="B48">Siyar et&#x20;al., 2020</xref>) Another advantage is that AR can repeat a simulated procedure as many times as desired, which is not practical in real patients or real environment. (<xref ref-type="bibr" rid="B18">Izard et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B5">Cao and Cerfolio, 2019</xref>) Pilot studies suggested that AR was a useful tool to create engaging and easy to use learning experiences in pharmacy education. (<xref ref-type="bibr" rid="B40">Salem et&#x20;al., 2020</xref>; <xref ref-type="bibr" rid="B43">Schneider et&#x20;al., 2020</xref>) Pharmacy students showed improvement in drug knowledge after completing the AR exercise and reported high usability and acceptability of AR for learning. (<xref ref-type="bibr" rid="B40">Salem et&#x20;al., 2020</xref>; <xref ref-type="bibr" rid="B43">Schneider et&#x20;al., 2020</xref>) AR technology can engage students into an active learning environment, which has been proven to be more effective than passive learning. (<xref ref-type="bibr" rid="B36">Ramnanan and Pound, 2017</xref>; <xref ref-type="bibr" rid="B50">Styers et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B9">Coyne et&#x20;al., 2019</xref>) The technical capabilities of AR can support a learning-by-doing approach stressed by the constructivist learning principles. (<xref ref-type="bibr" rid="B7">Chen, 2010</xref>) They are also useful tools for delivering knowledge through embodied cognition, which emphasizes the interaction between learner and the environment. (<xref ref-type="bibr" rid="B22">Dunleavy and Dede, 2013</xref>) Nonetheless, AR is still considered as new technology in terms of pedagogy. They have not been widely adopted in the curriculum, and most teachers and students have limited experience of applying AR in education.</p>
<p>The current study aimed to investigate student&#x2019;s perspectives on using AR as learning tools in undergraduate pharmacy education.</p>
</sec>
<sec sec-type="methods" id="s2">
<title>Methods</title>
<sec id="s2-1">
<title>Study Design and Study Population</title>
<p>Our study population included third year undergraduate pharmacy students from the Chinese University of Hong Kong (CUHK) in 2018/2019 school year. Yearly, we admitted up to 60 pharmacy students. The pharmacy curriculum lasted for 4&#xa0;years. In the first 2&#xa0;years, students learnt the basic biological concepts and laboratory skills. In the third year, students had in-depth training on drug pharmacology and therapeutic uses. In the fourth year, students had clerkship training at clinical sites. They needed to review patients&#x2019; conditions and propose treatment plans for them independently. After graduation, they would receive internship training at workplaces for 1&#xa0;year before registration.</p>
<p>The AR micro modules were used in the course &#x201c;Clinical Assessment and Monitoring&#x201d;, which was a 3-units (3&#xa0;h per week for a total of 13&#xa0;weeks) compulsory course for third year pharmacy students at CUHK. It was a preparatory course prior to the clinical clerkship for the pharmacy students at the teaching hospital. This course involved classroom teaching on the theories on drug therapy assessment and therapeutic outcomes monitoring skills, as well as practicum in which students needed to apply previous knowledge on therapeutics to evaluate real patient cases in the teaching hospital. Upon completion of the course, students should be able to obtain medication-related information accurately, retrieve laboratory test results and vital signs, identify and utilise drug information resources to assist with patient-specific drug therapy monitoring, and present patient cases comprehensively.</p>
<p>Traditionally, learning activities of &#x201c;Clinical Assessment and Monitoring&#x201d; included lectures, discussion, medication chart review, and presentations. Teachers illustrated the technique of patient assessment by showing students some written case summaries, photos, and videos during lectures. Afterwards, students needed to review real patient cases, present the cases in class, and provide their recommendations. In the current study, four AR modules on post-stroke management and chronic obstructive pulmonary disease (COPD) were developed to illustrate clinical cases during lectures. These two topics were chosen for two major reasons. Firstly, pharmacology and therapeutics knowledge on COPD and stroke were covered in the course &#x2018;Pharmacology and Therapeutics I&#x2019; (offered in year 2 semester 2) and &#x2018;Pharmacology and Therapeutics II&#x2019; (offered in year 3 semester 1), respectively. Students taking the course &#x2018;Clinical Assessment and Monitoring&#x2019; (offered in year 3 semester 2) should have adequate knowledge on the pharmacological management of COPD and stroke. Thus, the AR modules could focus on training students&#x2019; drug therapy assessment skill and patient counselling skill. Conversely, if diseases covered in &#x2018;Pharmacology and Therapeutics III&#x2019; (offered in year 3 semester 2) or &#x2018;Pharmacology and Therapeutics IV&#x2019; (offered in year 4 semester 1) were chosen, extra time and effort would be needed to introduce the fundamental knowledge of disease management. Secondly, COPD and post-stroke management involved different pharmacist assessment skills, such as assessing disease control, inhaler technique, pharmacological and non-pharmacological treatment to improve patients&#x2019; outcomes, etc. Previous students taking the same course often found them difficult to gather information and give advice when working on the real patient cases. The AR modules allowed students to practise their patient interview and counselling skills before working on the real&#x20;cases.</p>
</sec>
<sec id="s2-2">
<title>Materials</title>
<p>Four AR micro modules on post-stroke management and COPD were launched. In each micro module, students were provided with a brief description of patient&#x2019;s case background and pictures showing hospital or clinic settings. Students needed to collect information on patient&#x2019;s chief complaint, past medical history, social history, current medications, and laboratory tests results in order to assess patient&#x2019;s disease control and recommend treatment plans. To collect the required information, students needed to use an AR scanning application, Layar, in their mobile device to scan and view the hidden items on each picture. The items included videos, audios, texts, and graphics. Students would be able to identify patient&#x2019;s chief complaints, history, risk factors, comorbidities, and other problems in the process. An example of COPD module was shown in <xref ref-type="fig" rid="F1">Figure&#x20;1</xref>. A short paragraph describing the case background was first given to students. Then, students should scan the pictures (trigger images) located in different part of the classroom using Layar. By scanning a picture (trigger image) of an inhaled medication, students would get a video describing how the patient used the inhaler (overlay). By scanning a picture (trigger image) of a health questionnaire, students would get a patient interview audio describing patient&#x2019;s lifestyle, smoking habit, and sleep pattern (overlay). With the hidden information collected, students would be able to assess patient&#x2019;s condition and propose treatment&#x20;plans.</p>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption>
<p>Content of a COPD micro module with case background, picture, and video script.</p>
</caption>
<graphic xlink:href="feduc-06-756907-g001.tif"/>
</fig>
<p>In the classroom, students first worked on the AR cases individually, then discussed the clinical problems shown in the cases with their classmates and provided their recommendation on the treatment plans. The teacher guided the discussion, addressed student&#x2019;s questions, and provided feedback and suggestions to the proposed treatment&#x20;plans.</p>
</sec>
<sec id="s2-3">
<title>Statistical Analysis</title>
<p>Pre- and post-self-evaluation surveys were used to assess the changes in students&#x2019; knowledge on the relevant topics, evaluate the changes in their confidence on patient counselling, and collect feedbacks from students regarding their learning experience. Students were asked to rate, using Likert Scale of 1 (strongly disagree) to 5 (strongly agree), their self-perceived knowledge and confidence on COPD and post-stroke management in the pre- and post-survey. Data were presented as mean&#x20;&#xb1; standard deviation. The changes in student&#x2019;s score before and after engaging in AR learning activities were assessed by Wilcoxon signed-rank test. Statistically significance was defined as <italic>p</italic>-value &#x3c; 0.05. All statistical analyses were performed using IBM SPSS Statistics version 26. All students provided their written informed consent before participating in this&#x20;study.</p>
</sec>
</sec>
<sec sec-type="results" id="s3">
<title>Results</title>
<p>A total of 54 third year pharmacy students participated in the current study. There were 50 (92.59%) and 44 (81.48%) students who completed the pre-test and post-test respectively.</p>
<p>
<xref ref-type="table" rid="T1">Table&#x20;1</xref> summarized the changes in student&#x2019;s knowledge, confidence in patient counselling, and their learning experience with the AR micro modules. Students perceived that they were more familiar with COPD and post-stroke management, and were more confident with patient counselling. The changes were not statistically significant. However, students expressed negative feeling on their learning experience and gave lower scores in the post-test when asked whether they enjoyed using AR as learning tools and whether AR could support learning.</p>
<table-wrap id="T1" position="float">
<label>TABLE 1</label>
<caption>
<p>Student&#x2019;s feedback on AR micro modules.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Changes in students&#x2019; knowledge</th>
<th align="left">Pre-test (n&#x20;&#x3d;&#x20;50)</th>
<th align="left">Post-test (n&#x20;&#x3d;&#x20;44)</th>
<th align="left">
<italic>p</italic>-value</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">I am familiar with COPD.</td>
<td align="char" char="plusmn">2.74&#x20;&#xb1; 0.88</td>
<td align="char" char="plusmn">2.80&#x20;&#xb1; 0.85</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.79</td>
</tr>
<tr>
<td align="left">I am familiar with post-stroke</td>
<td align="char" char="plusmn">2.22&#x20;&#xb1; 0.95</td>
<td align="char" char="plusmn">2.55&#x20;&#xb1; 0.87</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.17</td>
</tr>
<tr>
<td colspan="4" align="left">
<bold>Changes in students&#x2019; confidence in patient counselling</bold>
</td>
</tr>
<tr>
<td align="left">I am confident to give a consultation to a COPD patient</td>
<td align="char" char="plusmn">2.34&#x20;&#xb1; 1.02</td>
<td align="char" char="plusmn">2.55&#x20;&#xb1; 0.98</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.43</td>
</tr>
<tr>
<td align="left">I am confident to give a consultation to a post-stroke patient</td>
<td align="char" char="plusmn">2.06&#x20;&#xb1; 0.98</td>
<td align="char" char="plusmn">2.43&#x20;&#xb1; 0.97</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.09</td>
</tr>
<tr>
<td align="left">Generally speaking, I am very confident with my patient consultation skills</td>
<td align="char" char="plusmn">2.30&#x20;&#xb1; 0.93</td>
<td align="char" char="plusmn">2.61&#x20;&#xb1; 0.89</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.15</td>
</tr>
<tr>
<td colspan="4" align="left">
<bold>Students&#x2019; feedback</bold>
</td>
</tr>
<tr>
<td align="left">AR case studies can enhance my interest in learning certain disease topics</td>
<td align="char" char="plusmn">3.40&#x20;&#xb1; 0.83</td>
<td align="char" char="plusmn">2.90&#x20;&#xb1; 1.01</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.06</td>
</tr>
<tr>
<td align="left">AR supports authentic learning</td>
<td align="char" char="plusmn">3.48&#x20;&#xb1; 0.71</td>
<td align="char" char="plusmn">2.81&#x20;&#xb1; 1.06</td>
<td align="left">
<italic>p</italic>&#x20;&#x3c; 0.01</td>
</tr>
<tr>
<td align="left">AR allows me to experience patient cases which would be impossible to generate in normal classroom environments</td>
<td align="char" char="plusmn">3.56&#x20;&#xb1; 0.81</td>
<td align="char" char="plusmn">2.95&#x20;&#xb1; 1.12</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.01</td>
</tr>
<tr>
<td align="left">AR develops an immersive learning experience</td>
<td align="char" char="plusmn">3.48&#x20;&#xb1; 0.68</td>
<td align="char" char="plusmn">2.84&#x20;&#xb1; 1.06</td>
<td align="left">
<italic>p</italic>&#x20;&#x3c; 0.01</td>
</tr>
<tr>
<td align="left">I enjoy using AR as a learning tool</td>
<td align="char" char="plusmn">3.24&#x20;&#xb1; 0.85</td>
<td align="char" char="plusmn">2.75&#x20;&#xb1; 1.12</td>
<td align="left">
<italic>p</italic>&#x20;&#x3d; 0.02</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>AR: augmented reality; COPD: chronic obstructive pulmonary disease.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<p>Students left both positive and negative comments on the survey. In general, students appreciated teacher&#x2019;s effort in designing the micro modules. They thought that the AR exercise could resemble real life practice, in which they needed to search for scattered patient information. One student wrote &#x201c;I think it is good, since it is in outreach settings, some medical information about the patient cannot be obtained, and we have to analyze the case based on limited information, which is quite realistic.&#x201d; The major issue students raised was technical problem. A student wrote &#x201c;Many of us cannot scan very well, especially in the lecture theatre.&#x201d; Another student wrote &#x201c;Take too much time scanning, but actually can put the images online in advance.&#x201d; Some students though there was not a big difference between AR micro modules and their usual case study exercises.</p>
</sec>
<sec sec-type="discussion" id="s4">
<title>Discussion</title>
<p>In recent years, the scope of AR application has expanded, ranging from entertainment, urban planning, travelling, education, to healthcare. The use of AR in medical education has increased with the intention of achieving the potential benefits. One advantage is to make a patient case reproducible. (<xref ref-type="bibr" rid="B18">Izard et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B5">Cao and Cerfolio, 2019</xref>) In pharmacy education, AR exercises allow students to practise their drug therapy assessment skills and patient counselling skills anytime. (<xref ref-type="bibr" rid="B13">Fox and Felkey, 2017</xref>; <xref ref-type="bibr" rid="B55">Ventola, 2019</xref>) Previous studies had revealed an important benefit of virtual reality (VR) and AR exercises, which was to allow students to make mistakes while showing them the consequences of making a wrong decision. (<xref ref-type="bibr" rid="B10">Davidson et&#x20;al., 2012</xref>; <xref ref-type="bibr" rid="B32">Nifakos et&#x20;al., 2014</xref>) It could strengthen their memories on clinical knowledge and skills. Besides, VR and AR exercises allow each student to participate in the cases. In ward round settings, it is not feasible for each student to interview the same patient. VR and AR exercises can eliminate the time constraint and avoid disturbing the patient. (<xref ref-type="bibr" rid="B26">McGrath et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B11">Fealy et&#x20;al., 2019</xref>) In addition, a teacher could run several simulated exercises at the same time, which further reduce the time constraint of teaching staff and students could gain more practice experience. (<xref ref-type="bibr" rid="B6">Caudell et&#x20;al., 2003</xref>) Our study population, third year pharmacy students, had not started bedside learning. They did not have hands-on experience of reading case notes, taking patients history, or counselling patients. The AR exercises offered students the chance to practise and polish their skills before they entered clinical year and internship.</p>
<p>Despite the theoretical benefits that AR exercises can bring to medical education, studies have identified the limitations and problems in actual practice (<xref ref-type="bibr" rid="B54">Uruthiralingam and Rea, 2020</xref>). A systematic review by Gerup et&#x20;al. analysed 26 studies involving AR or mixed reality in healthcare education. (<xref ref-type="bibr" rid="B15">Gerup et&#x20;al., 2020</xref>) Gerup et&#x20;al. pointed out the weaknesses of the studies, as well as the common difficulties with using AR as reported by the studies. (<xref ref-type="bibr" rid="B15">Gerup et&#x20;al., 2020</xref>) One major problem identified was the inadequate evidence for improving learning. Studies were often designed as single group user studies, (<xref ref-type="bibr" rid="B25">Ma et&#x20;al., 2016</xref>; <xref ref-type="bibr" rid="B56">Wang et&#x20;al., 2016</xref>; <xref ref-type="bibr" rid="B49">Solbiati et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B27">Mewes et&#x20;al., 2019</xref>) and many presented descriptive findings from self-reported evaluations without statistical analysis. (<xref ref-type="bibr" rid="B51">Sutherland et&#x20;al., 2013</xref>; <xref ref-type="bibr" rid="B4">Bifulco et&#x20;al., 2014</xref>; <xref ref-type="bibr" rid="B25">Ma et&#x20;al., 2016</xref>; <xref ref-type="bibr" rid="B56">Wang et&#x20;al., 2016</xref>; <xref ref-type="bibr" rid="B19">Kugelmann et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B49">Solbiati et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B61">Zhu et&#x20;al., 2018</xref>; <xref ref-type="bibr" rid="B27">Mewes et&#x20;al., 2019</xref>) This limited the generalisability of study results. Moreover, a portion of the studies reported no significant impact of AR on enhancing student&#x2019;s learning outcomes. (<xref ref-type="bibr" rid="B30">Moult et&#x20;al., 2013</xref>; <xref ref-type="bibr" rid="B29">Moro et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B33">Noll et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B38">Rochlen et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B46">Siebert et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B57">Wang et&#x20;al., 2017</xref>; <xref ref-type="bibr" rid="B16">Huang et&#x20;al., 2018</xref>) Technological limitations were the common challenge reported among the studies. (<xref ref-type="bibr" rid="B15">Gerup et&#x20;al., 2020</xref>)</p>
<p>In view of the conflicting results, there is a need to conduct a thorough assessment on how AR technology can facilitate student&#x2019;s learning, as well as evaluate student&#x2019;s perspectives on the new pedagogy. Our results echoed that reported in literature. Technical issues were the major problem that teachers and students encountered. Extra effort was needed to play an AR or VR video in usual classroom settings, as compared to a plain video. (<xref ref-type="bibr" rid="B6">Caudell et&#x20;al., 2003</xref>; <xref ref-type="bibr" rid="B41">Samaniego Villarroel, 2016</xref>) For example, it took longer time for teachers to set up the devices in the classroom and for students to download the videos in their laptops. If the classrooms were not covered with stable network, it would take much more time for downloading the videos and graphics in class. In addition, playing AR or VR videos drained away the battery in the laptops quickly. It would be un-user-friendly if hardware supports were inadequate. As a result, student&#x2019;s learning experience was not positive. On the other hand, there was no significant difference in student&#x2019;s perceived knowledge and confidence with the topics. It might be because the AR exercises mainly simulated the patient interview and data collection process. Students evaluated their performance mainly through in-class discussion with peers and by listening to teacher&#x2019;s comments after class. Instant feedback from the AR exercises was limited. Thus, some students thought the learning objectives could be achieved by using conventional paper cases, which requires less preparation time and manpower.</p>
<p>With e-learning being more and more dominant in education, the prevalence of using AR in teaching is expected to grow. (<xref ref-type="bibr" rid="B3">Bacca et&#x20;al., 2014</xref>; <xref ref-type="bibr" rid="B24">Lilly et&#x20;al., 2019</xref>) Under the continued influence of Covid-19 pandemics, a lot of teaching activities such as practicum, clerkship, and clinical attachment had been called off. (<xref ref-type="bibr" rid="B2">Ahmed et&#x20;al., 2020</xref>; <xref ref-type="bibr" rid="B31">Newman and Lattouf, 2020</xref>; <xref ref-type="bibr" rid="B35">Rajab et&#x20;al., 2020</xref>; <xref ref-type="bibr" rid="B47">Singh et&#x20;al., 2020</xref>) AR cases could provide alternative channels for students to learn. As technology advances, AR are getting more common in medical practice. (<xref ref-type="bibr" rid="B23">Li et&#x20;al., 2017</xref>) It is expected that students will come across AR in their future careers. It would be beneficial for students to adapt to the technology during university study. Thus, the role of AR in the pharmacy curriculum should be further explored. Still, to ensure that AR technology can really add values to medical education, it is essential to define the learning objectives clearly and conduct structured evaluation on student&#x2019;s learning outcomes. Given that the time and financial cost required to produce an AR video are much longer than that of a plain video, it is crucial to select suitable topics when designing the teaching materials. Otherwise, AR exercises may not be cost-effective if the knowledge can be conveyed in a more straightforward&#x20;way.</p>
<p>There are a few limitations in the study. Firstly, the impact of AR micro modules on student&#x2019;s learning was evaluated based on self-assessment. The cases were discussed in class to make sure students knew the right answers, but there was no specific quiz to formally assess the gain in knowledge among students. A more concrete relationship between the use of AR and student&#x2019;s performance could be established if their examination results were compared. Secondly, the sample size of this study was limited by the class size of pharmacy department. Student&#x2019;s opinions and suggestions had been collected in the study. The tools should first be modified, then the survey can be repeated in the subsequent years to increase the sample&#x20;size.</p>
</sec>
<sec sec-type="conclusion" id="s5">
<title>Conclusion</title>
<p>There was no significant difference in pharmacy students perceived clinical knowledge and confidence on patient&#x2019;s counselling after completing the AR modules. Technical issues were the major hurdles that hindered student&#x2019;s learning experience with&#x20;AR.</p>
</sec>
</body>
<back>
<sec id="s6">
<title>Data Availability Statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec id="s7">
<title>Ethics Statement</title>
<p>The studies involving human participants were reviewed and approved by Survey and Behavioural Research Ethics Committee of the Chinese University of Hong Kong. Reference number: 14610518. The patients/participants provided their written informed consent to participate in this&#x20;study.</p>
</sec>
<sec id="s8">
<title>Author Contributions</title>
<p>All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication. JL analysed data and wrote the article, EN arranged the logistics and prepared teaching materials, VL contributed to the study design and supervised the study.</p>
</sec>
<sec id="s9">
<title>Funding</title>
<p>This study was funded by Teaching Development and Language Enhancement Grant for 2016-19 Triennium from The Chinese University of Hong Kong. The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.</p>
</sec>
<sec sec-type="COI-statement" id="s10">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s11">
<title>Publisher&#x2019;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec sec-type="abbreviation" id="s12">
<title>Abbreviations</title>
<p>AR, Augmented reality; COPD, Chronic obstructive pulmonary disease; CUHK, The Chinese University of Hong&#x20;Kong.</p>
</sec>
<ref-list>
<title>References</title>
<ref id="B1">
<citation citation-type="book">
<collab>ACPE</collab> (<year>2015</year>). <source>Accreditation Standards and Key Elements for the Professional Program in Pharmacy Leading to the Doctor of Pharmacy Degree</source>. <comment>Available at <ext-link ext-link-type="uri" xlink:href="https://www.acpe-accredit.org/standards/">https://www.acpe-accredit.org/standards/</ext-link> (Accessed December 22, 2020)</comment> </citation>
</ref>
<ref id="B2">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ahmed</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Allaf</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Elghazaly</surname>
<given-names>H.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>COVID-19 and Medical Education</article-title>. <source>Lancet Infect. Dis.</source> <volume>20</volume> (<issue>7</issue>), <fpage>777</fpage>&#x2013;<lpage>778</lpage>. <pub-id pub-id-type="doi">10.1016/S1473-3099(20)30226-7</pub-id> </citation>
</ref>
<ref id="B3">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bacca</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Baldiris</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Fabregat</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Graf</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Kinshuk</surname>
</name>
</person-group> (<year>2014</year>). <article-title>Augmented Reality Trends in Education: A Systematic Review of Research and Applications</article-title>. <source>Educ. Techn. Soc.</source> <volume>17</volume> (<issue>4</issue>), <fpage>133</fpage>&#x2013;<lpage>149</lpage>. </citation>
</ref>
<ref id="B4">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bifulco</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Narducci</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Vertucci</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Ambruosi</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Cesarelli</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Romano</surname>
<given-names>M.</given-names>
</name>
</person-group> (<year>2014</year>). <article-title>Telemedicine Supported by Augmented Reality: an Interactive Guide for Untrained People in Performing an ECG Test</article-title>. <source>Biomed. Eng. Online</source> <volume>13</volume>, <fpage>153</fpage>. <pub-id pub-id-type="doi">10.1186/1475-925X-13-153</pub-id> </citation>
</ref>
<ref id="B5">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Cao</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Cerfolio</surname>
<given-names>R. J.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>Virtual or Augmented Reality to Enhance Surgical Education and Surgical Planning</article-title>. <source>Thorac. Surg. Clin.</source> <volume>29</volume> (<issue>3</issue>), <fpage>329</fpage>&#x2013;<lpage>337</lpage>. <pub-id pub-id-type="doi">10.1016/j.thorsurg.2019.03.010</pub-id> </citation>
</ref>
<ref id="B6">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Caudell</surname>
<given-names>T. P.</given-names>
</name>
<name>
<surname>Summers</surname>
<given-names>K. L.</given-names>
</name>
<name>
<surname>Holten</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Hakamata</surname>
<given-names>T.</given-names>
</name>
<name>
<surname>Mowafi</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Jacobs</surname>
<given-names>J.</given-names>
</name>
<etal/>
</person-group> (<year>2003</year>). <article-title>Virtual Patient Simulator for Distributed Collaborative Medical Education</article-title>. <source>Anat. Rec. B New Anat.</source> <volume>270</volume> (<issue>1</issue>), <fpage>23</fpage>&#x2013;<lpage>29</lpage>. <pub-id pub-id-type="doi">10.1002/ar.b.10007</pub-id> </citation>
</ref>
<ref id="B7">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chen</surname>
<given-names>C. J.</given-names>
</name>
</person-group> (<year>2010</year>). <article-title>Theoretical Bases for Using Virtual Reality in Education</article-title>. <source>Themes Sci. Techn. Educ.</source> <volume>2</volume> (<issue>1-2</issue>), <fpage>71</fpage>&#x2013;<lpage>90</lpage>. </citation>
</ref>
<ref id="B8">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chen</surname>
<given-names>P. C.</given-names>
</name>
<name>
<surname>Gadepalli</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>MacDonald</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Kadowaki</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Nagpal</surname>
<given-names>K.</given-names>
</name>
<etal/>
</person-group> (<year>2019</year>). <article-title>An Augmented Reality Microscope with Real-Time Artificial Intelligence Integration for Cancer Diagnosis</article-title>. <source>Nat. Med.</source> <volume>25</volume> (<issue>9</issue>), <fpage>1453</fpage>&#x2013;<lpage>1457</lpage>. <pub-id pub-id-type="doi">10.1038/s41591-019-0539-7</pub-id> </citation>
</ref>
<ref id="B9">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Coyne</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Merritt</surname>
<given-names>T. A.</given-names>
</name>
<name>
<surname>Parmentier</surname>
<given-names>B. L.</given-names>
</name>
<name>
<surname>Sharpton</surname>
<given-names>R. A.</given-names>
</name>
<name>
<surname>Takemoto</surname>
<given-names>J.&#x20;K.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>The Past, Present, and Future of Virtual Reality in Pharmacy Education</article-title>. <source>Am. J.&#x20;Pharm. Educ.</source> <volume>83</volume> (<issue>3</issue>), <fpage>7456</fpage>. <pub-id pub-id-type="doi">10.5688/ajpe7456</pub-id> </citation>
</ref>
<ref id="B10">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Davidson</surname>
<given-names>I. J.</given-names>
</name>
<name>
<surname>Lok</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Dolmatch</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Gallieni</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Nolen</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Pittiruti</surname>
<given-names>M.</given-names>
</name>
<etal/>
</person-group> (<year>2012</year>). <article-title>Virtual Reality: Emerging Role of Simulation Training in Vascular Access</article-title>. <source>Semin. Nephrol.</source> <volume>32</volume> (<issue>6</issue>), <fpage>572</fpage>&#x2013;<lpage>581</lpage>. <pub-id pub-id-type="doi">10.1016/j.semnephrol.2012.10.009</pub-id> </citation>
</ref>
<ref id="B22">
<citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname>Dunleavy</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Dede</surname>
<given-names>C.</given-names>
</name>
</person-group> (<year>2013</year>). &#x201C;<article-title>Augmented Reality Teaching and Learning</article-title>,&#x201D; in <source>Handbook of Research on Educational Communications and Technology</source>. (<publisher-loc>New York, NY</publisher-loc>: <publisher-name>Springer</publisher-name>), <fpage>735</fpage>&#x2013;<lpage>745</lpage>. </citation>
</ref>
<ref id="B11">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Fealy</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Jones</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Hutton</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Graham</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>McNeill</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Sweet</surname>
<given-names>L.</given-names>
</name>
<etal/>
</person-group> (<year>2019</year>). <article-title>The Integration of Immersive Virtual Reality in Tertiary Nursing and Midwifery Education: A Scoping Review</article-title>. <source>Nurse Educ. Today</source> <volume>79</volume>, <fpage>14</fpage>&#x2013;<lpage>19</lpage>. <pub-id pub-id-type="doi">10.1016/j.nedt.2019.05.002</pub-id> </citation>
</ref>
<ref id="B12">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Feng</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Ma</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>G.</given-names>
</name>
<etal/>
</person-group> (<year>2019</year>). <article-title>Virtual Reality Rehabilitation versus Conventional Physical Therapy for Improving Balance and Gait in Parkinson&#x27;s Disease Patients: A Randomized Controlled Trial</article-title>. <source>Med. Sci. Monit.</source> <volume>25</volume>, <fpage>4186</fpage>&#x2013;<lpage>4192</lpage>. <pub-id pub-id-type="doi">10.12659/MSM.916455</pub-id> </citation>
</ref>
<ref id="B13">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Fox</surname>
<given-names>B. I.</given-names>
</name>
<name>
<surname>Felkey</surname>
<given-names>B. G.</given-names>
</name>
</person-group> (<year>2017</year>). <article-title>Virtual Reality and Pharmacy: Opportunities and Challenges</article-title>. <source>Hosp. Pharm.</source> <volume>52</volume> (<issue>2</issue>), <fpage>160</fpage>&#x2013;<lpage>161</lpage>. <pub-id pub-id-type="doi">10.1310/hpj5202-160</pub-id> </citation>
</ref>
<ref id="B14">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Freeman</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Reeve</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Robinson</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Ehlers</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Clark</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Spanlang</surname>
<given-names>B.</given-names>
</name>
<etal/>
</person-group> (<year>2017</year>). <article-title>Virtual Reality in the Assessment, Understanding, and Treatment of Mental Health Disorders</article-title>. <source>Psychol. Med.</source> <volume>47</volume> (<issue>14</issue>), <fpage>2393</fpage>&#x2013;<lpage>2400</lpage>. <pub-id pub-id-type="doi">10.1017/S003329171700040X</pub-id> </citation>
</ref>
<ref id="B15">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gerup</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Soerensen</surname>
<given-names>C. B.</given-names>
</name>
<name>
<surname>Dieckmann</surname>
<given-names>P.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Augmented Reality and Mixed Reality for Healthcare Education beyond Surgery: an Integrative Review</article-title>. <source>Int. J.&#x20;Med. Educ.</source> <volume>11</volume>, <fpage>1</fpage>&#x2013;<lpage>18</lpage>. <pub-id pub-id-type="doi">10.5116/ijme.5e01.eb1a</pub-id> </citation>
</ref>
<ref id="B16">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Huang</surname>
<given-names>C. Y.</given-names>
</name>
<name>
<surname>Thomas</surname>
<given-names>J.&#x20;B.</given-names>
</name>
<name>
<surname>Alismail</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Cohen</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Almutairi</surname>
<given-names>W.</given-names>
</name>
<name>
<surname>Daher</surname>
<given-names>N. S.</given-names>
</name>
<etal/>
</person-group> (<year>2018</year>). <article-title>The Use of Augmented Reality Glasses in central Line Simulation: "see One, Simulate many, Do One Competently, and Teach Everyone"</article-title>. <source>Adv. Med. Educ. Pract.</source> <volume>9</volume>, <fpage>357</fpage>&#x2013;<lpage>363</lpage>. <pub-id pub-id-type="doi">10.2147/AMEP.S160704</pub-id> </citation>
</ref>
<ref id="B17">
<citation citation-type="web">
<collab>Investopedia</collab> (<year>2020</year>). <article-title>Augmented Reality</article-title>. <comment>Available at: <ext-link ext-link-type="uri" xlink:href="https://www.investopedia.com/terms/a/augmented-reality.asp">https://www.investopedia.com/terms/a/augmented-reality.asp</ext-link> (Accessed Nov 4, 2020)</comment>. </citation>
</ref>
<ref id="B18">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Izard</surname>
<given-names>S. G.</given-names>
</name>
<name>
<surname>Juanes</surname>
<given-names>J.&#x20;A.</given-names>
</name>
<name>
<surname>Garc&#xed;a Pe&#xf1;alvo</surname>
<given-names>F. J.</given-names>
</name>
<name>
<surname>Estella</surname>
<given-names>J.&#x20;M. G.</given-names>
</name>
<name>
<surname>Ledesma</surname>
<given-names>M. J.&#x20;S.</given-names>
</name>
<name>
<surname>Ruisoto</surname>
<given-names>P.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Virtual Reality as an Educational and Training Tool for Medicine</article-title>. <source>J.&#x20;Med. Syst.</source> <volume>42</volume> (<issue>3</issue>), <fpage>50</fpage>. <pub-id pub-id-type="doi">10.1007/s10916-018-0900-2</pub-id> </citation>
</ref>
<ref id="B19">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kugelmann</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Stratmann</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>N&#xfc;hlen</surname>
<given-names>N.</given-names>
</name>
<name>
<surname>Bork</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Hoffmann</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Samarbarksh</surname>
<given-names>G.</given-names>
</name>
<etal/>
</person-group> (<year>2018</year>). <article-title>An Augmented Reality Magic Mirror as Additive Teaching Device for Gross Anatomy</article-title>. <source>Ann. Anat.</source> <volume>215</volume>, <fpage>71</fpage>&#x2013;<lpage>77</lpage>. <pub-id pub-id-type="doi">10.1016/j.aanat.2017.09.011</pub-id> </citation>
</ref>
<ref id="B20">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Lang</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Zhang</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Lin</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Han</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Zhang</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>Y.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>Team-based Learning Pedagogy Enhances the Quality of Chinese Pharmacy Education: a Systematic Review and Meta-Analysis</article-title>. <source>BMC Med. Educ.</source> <volume>19</volume> (<issue>1</issue>), <fpage>286</fpage>. <pub-id pub-id-type="doi">10.1186/s12909-019-1724-6</pub-id> </citation>
</ref>
<ref id="B21">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Laver</surname>
<given-names>K. E.</given-names>
</name>
<name>
<surname>Lange</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>George</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Deutsch</surname>
<given-names>J.&#x20;E.</given-names>
</name>
<name>
<surname>Saposnik</surname>
<given-names>G.</given-names>
</name>
<name>
<surname>Crotty</surname>
<given-names>M.</given-names>
</name>
</person-group> (<year>2017</year>). <article-title>Virtual Reality for Stroke Rehabilitation</article-title>. <source>Cochrane Database Syst. Rev.</source> <volume>11</volume> (<issue>11</issue>), <fpage>CD008349</fpage>. <pub-id pub-id-type="doi">10.1002/14651858.CD008349.pub4</pub-id> </citation>
</ref>
<ref id="B23">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Li</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Yu</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Shi</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Shi</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Tian</surname>
<given-names>Z.</given-names>
</name>
<name>
<surname>Yang</surname>
<given-names>J.</given-names>
</name>
<etal/>
</person-group> (<year>2017</year>). <article-title>Application of Virtual Reality Technology in Clinical Medicine</article-title>. <source>Am. J.&#x20;Transl. Res.</source> <volume>9</volume> (<issue>9</issue>), <fpage>3867</fpage>&#x2013;<lpage>3880</lpage>. </citation>
</ref>
<ref id="B24">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Lilly</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Kaneshiro</surname>
<given-names>K. N.</given-names>
</name>
<name>
<surname>Misquith</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Dennett</surname>
<given-names>B.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>Creating a New "reality" for Medical Education: the Nexus Reality Lab for Virtual Reality</article-title>. <source>J.&#x20;Med. Libr. Assoc.</source> <volume>107</volume> (<issue>4</issue>), <fpage>609</fpage>&#x2013;<lpage>610</lpage>. <pub-id pub-id-type="doi">10.5195/jmla.2019.784</pub-id> </citation>
</ref>
<ref id="B25">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ma</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Fallavollita</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Seelbach</surname>
<given-names>I.</given-names>
</name>
<name>
<surname>Von Der Heide</surname>
<given-names>A. M.</given-names>
</name>
<name>
<surname>Euler</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Waschke</surname>
<given-names>J.</given-names>
</name>
<etal/>
</person-group> (<year>2016</year>). <article-title>Personalized Augmented Reality for Anatomy Education</article-title>. <source>Clin. Anat.</source> <volume>29</volume> (<issue>4</issue>), <fpage>446</fpage>&#x2013;<lpage>453</lpage>. <pub-id pub-id-type="doi">10.1002/ca.22675</pub-id> </citation>
</ref>
<ref id="B26">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>McGrath</surname>
<given-names>J.&#x20;L.</given-names>
</name>
<name>
<surname>Taekman</surname>
<given-names>J.&#x20;M.</given-names>
</name>
<name>
<surname>Dev</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Danforth</surname>
<given-names>D. R.</given-names>
</name>
<name>
<surname>Mohan</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Kman</surname>
<given-names>N.</given-names>
</name>
<etal/>
</person-group> (<year>2018</year>). <article-title>Using Virtual Reality Simulation Environments to Assess Competence for Emergency Medicine Learners</article-title>. <source>Acad. Emerg. Med.</source> <volume>25</volume> (<issue>2</issue>), <fpage>186</fpage>&#x2013;<lpage>195</lpage>. <pub-id pub-id-type="doi">10.1111/acem.13308</pub-id> </citation>
</ref>
<ref id="B27">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Mewes</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Heinrich</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>K&#xe4;gebein</surname>
<given-names>U.</given-names>
</name>
<name>
<surname>Hensen</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Wacker</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Hansen</surname>
<given-names>C.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>Projector-based Augmented Reality System for Interventional Visualization inside MRI Scanners</article-title>. <source>Int. J.&#x20;Med. Robot.</source> <volume>15</volume> (<issue>1</issue>), <fpage>e1950</fpage>. <pub-id pub-id-type="doi">10.1002/rcs.1950</pub-id> </citation>
</ref>
<ref id="B28">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Miller</surname>
<given-names>D. M.</given-names>
</name>
<name>
<surname>Khalil</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>Iskaros</surname>
<given-names>O.</given-names>
</name>
<name>
<surname>Van Amburgh</surname>
<given-names>J.&#x20;A.</given-names>
</name>
</person-group> (<year>2017</year>). <article-title>Professional and Pre-professional Pharmacy Students&#x27; Perceptions of Team Based Learning (TBL) at a Private Research-Intensive university</article-title>. <source>Curr. Pharm. Teach. Learn.</source> <volume>9</volume> (<issue>4</issue>), <fpage>666</fpage>&#x2013;<lpage>670</lpage>. <pub-id pub-id-type="doi">10.1016/j.cptl.2017.03.001</pub-id> </citation>
</ref>
<ref id="B29">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Moro</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>&#x160;tromberga</surname>
<given-names>Z.</given-names>
</name>
<name>
<surname>Raikos</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Stirling</surname>
<given-names>A.</given-names>
</name>
</person-group> (<year>2017</year>). <article-title>The Effectiveness of Virtual and Augmented Reality in Health Sciences and Medical Anatomy</article-title>. <source>Anat. Sci. Educ.</source> <volume>10</volume> (<issue>6</issue>), <fpage>549</fpage>&#x2013;<lpage>559</lpage>. <pub-id pub-id-type="doi">10.1002/ase.1696</pub-id> </citation>
</ref>
<ref id="B30">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Moult</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Ungi</surname>
<given-names>T.</given-names>
</name>
<name>
<surname>Welch</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Lu</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>McGraw</surname>
<given-names>R. C.</given-names>
</name>
<name>
<surname>Fichtinger</surname>
<given-names>G.</given-names>
</name>
</person-group> (<year>2013</year>). <article-title>Ultrasound-guided Facet Joint Injection Training Using Perk Tutor</article-title>. <source>Int. J.&#x20;Comput. Assist. Radiol. Surg.</source> <volume>8</volume> (<issue>5</issue>), <fpage>831</fpage>&#x2013;<lpage>836</lpage>. <pub-id pub-id-type="doi">10.1007/s11548-012-0811-5</pub-id> </citation>
</ref>
<ref id="B31">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Newman</surname>
<given-names>N. A.</given-names>
</name>
<name>
<surname>Lattouf</surname>
<given-names>O. M.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Coalition for Medical Education-A Call to Action: A Proposition to Adapt Clinical Medical Education to Meet the Needs of Students and Other Healthcare Learners during COVID-19</article-title>. <source>J.&#x20;Card. Surg.</source> <volume>35</volume> (<issue>6</issue>), <fpage>1174</fpage>&#x2013;<lpage>1175</lpage>. <pub-id pub-id-type="doi">10.1111/jocs.14590</pub-id> </citation>
</ref>
<ref id="B32">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Nifakos</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Tomson</surname>
<given-names>T.</given-names>
</name>
<name>
<surname>Zary</surname>
<given-names>N.</given-names>
</name>
</person-group> (<year>2014</year>). <article-title>Combining Physical and Virtual Contexts through Augmented Reality: Design and Evaluation of a Prototype Using a Drug Box as a Marker for Antibiotic Training</article-title>. <source>PeerJ</source> <volume>2</volume>, <fpage>e697</fpage>. <pub-id pub-id-type="doi">10.7717/peerj.697</pub-id> </citation>
</ref>
<ref id="B33">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Noll</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>von Jan</surname>
<given-names>U.</given-names>
</name>
<name>
<surname>Raap</surname>
<given-names>U.</given-names>
</name>
<name>
<surname>Albrecht</surname>
<given-names>U. V.</given-names>
</name>
</person-group> (<year>2017</year>). <article-title>Mobile Augmented Reality as a Feature for Self-Oriented, Blended Learning in Medicine: Randomized Controlled Trial</article-title>. <source>JMIR Mhealth Uhealth</source> <volume>5</volume> (<issue>9</issue>), <fpage>e139</fpage>. <pub-id pub-id-type="doi">10.2196/mhealth.7943</pub-id> </citation>
</ref>
<ref id="B34">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Okuda</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Bryson</surname>
<given-names>E. O.</given-names>
</name>
<name>
<surname>DeMaria</surname>
<given-names>S.</given-names>
<suffix>Jr</suffix>
</name>
<name>
<surname>Jacobson</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Quinones</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Shen</surname>
<given-names>B.</given-names>
</name>
<etal/>
</person-group> (<year>2009</year>). <article-title>The Utility of Simulation in Medical Education: what Is the Evidence?</article-title> <source>Mt Sinai J.&#x20;Med.</source> <volume>76</volume> (<issue>4</issue>), <fpage>330</fpage>&#x2013;<lpage>343</lpage>. <pub-id pub-id-type="doi">10.1002/msj.20127</pub-id> </citation>
</ref>
<ref id="B35">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Rajab</surname>
<given-names>M. H.</given-names>
</name>
<name>
<surname>Gazal</surname>
<given-names>A. M.</given-names>
</name>
<name>
<surname>Alkattan</surname>
<given-names>K.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Challenges to Online Medical Education during the COVID-19 Pandemic</article-title>. <source>Cureus</source> <volume>12</volume> (<issue>7</issue>), <fpage>e8966</fpage>. <pub-id pub-id-type="doi">10.7759/cureus.8966</pub-id> </citation>
</ref>
<ref id="B36">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ramnanan</surname>
<given-names>C. J.</given-names>
</name>
<name>
<surname>Pound</surname>
<given-names>L. D.</given-names>
</name>
</person-group> (<year>2017</year>). <article-title>Advances in Medical Education and Practice: Student Perceptions of the Flipped Classroom</article-title>. <source>Adv. Med. Educ. Pract.</source> <volume>8</volume>, <fpage>63</fpage>&#x2013;<lpage>73</lpage>. <pub-id pub-id-type="doi">10.2147/AMEP.S109037</pub-id> </citation>
</ref>
<ref id="B37">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ray</surname>
<given-names>S. M.</given-names>
</name>
<name>
<surname>Wylie</surname>
<given-names>D. R.</given-names>
</name>
<name>
<surname>Shaun Rowe</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Heidel</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Franks</surname>
<given-names>A. S.</given-names>
</name>
</person-group> (<year>2012</year>). <article-title>Pharmacy Student Knowledge Retention after Completing Either a Simulated or Written Patient Case</article-title>. <source>Am. J.&#x20;Pharm. Educ.</source> <volume>76</volume> (<issue>5</issue>), <fpage>86</fpage>. <pub-id pub-id-type="doi">10.5688/ajpe76586</pub-id> </citation>
</ref>
<ref id="B38">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Rochlen</surname>
<given-names>L. R.</given-names>
</name>
<name>
<surname>Levine</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Tait</surname>
<given-names>A. R.</given-names>
</name>
</person-group> (<year>2017</year>). <article-title>First-Person Point-of-View-Augmented Reality for Central Line Insertion Training: A Usability and Feasibility Study</article-title>. <source>Simul. Healthc.</source> <volume>12</volume> (<issue>1</issue>), <fpage>57</fpage>&#x2013;<lpage>62</lpage>. <pub-id pub-id-type="doi">10.1097/SIH.0000000000000185</pub-id> </citation>
</ref>
<ref id="B39">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Rothgangel</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Braun</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Winkens</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Beurskens</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Smeets</surname>
<given-names>R.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Traditional and Augmented Reality Mirror Therapy for Patients with Chronic Phantom Limb Pain (PACT Study): Results of a Three-Group, Multicentre Single-Blind Randomized Controlled Trial</article-title>. <source>Clin. Rehabil.</source> <volume>32</volume> (<issue>12</issue>), <fpage>1591</fpage>&#x2013;<lpage>1608</lpage>. <pub-id pub-id-type="doi">10.1177/0269215518785948</pub-id> </citation>
</ref>
<ref id="B40">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Salem</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Cooper</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Schneider</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Croft</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Munro</surname>
<given-names>I.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Student Acceptance of Using Augmented Reality Applications for Learning in Pharmacy: A Pilot Study</article-title>. <source>Pharmacy (Basel)</source> <volume>8</volume> (<issue>3</issue>), <fpage>122</fpage>. <pub-id pub-id-type="doi">10.3390/pharmacy8030122</pub-id> </citation>
</ref>
<ref id="B41">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Samaniego Villarroel</surname>
<given-names>J.&#x20;C.</given-names>
</name>
</person-group> (<year>2016</year>). <article-title>Realidad Virtual en la Educaci&#xf3;n el Pr&#xf3;ximo Desaf&#xed;o</article-title>. <source>Jsr</source> <volume>1</volume> (<issue>CITT2016</issue>), <fpage>57</fpage>&#x2013;<lpage>61</lpage>. <pub-id pub-id-type="doi">10.26910/issn.2528-8083</pub-id> </citation>
</ref>
<ref id="B42">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Sayadi</surname>
<given-names>L. R.</given-names>
</name>
<name>
<surname>Naides</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Eng</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Fijany</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Chopan</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Sayadi</surname>
<given-names>J.&#x20;J.</given-names>
</name>
<etal/>
</person-group> (<year>2019</year>). <article-title>The New Frontier: A Review of Augmented Reality and Virtual Reality in Plastic Surgery</article-title>. <source>Aesthet. Surg. J.</source> <volume>39</volume> (<issue>9</issue>), <fpage>1007</fpage>&#x2013;<lpage>1016</lpage>. <pub-id pub-id-type="doi">10.1093/asj/sjz043</pub-id> </citation>
</ref>
<ref id="B43">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Schneider</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Patfield</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Croft</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Salem</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Munro</surname>
<given-names>I.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Introducing Augmented Reality Technology to Enhance Learning in Pharmacy Education: A Pilot Study</article-title>. <source>Pharmacy (Basel)</source> <volume>8</volume> (<issue>3</issue>), <fpage>109</fpage>. <pub-id pub-id-type="doi">10.3390/pharmacy8030109</pub-id> </citation>
</ref>
<ref id="B44">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Shin</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Park</surname>
<given-names>J.&#x20;H.</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>J.&#x20;H.</given-names>
</name>
</person-group> (<year>2015</year>). <article-title>Effectiveness of Patient Simulation in Nursing Education: Meta-Analysis</article-title>. <source>Nurse Educ. Today</source> <volume>35</volume> (<issue>1</issue>), <fpage>176</fpage>&#x2013;<lpage>182</lpage>. <pub-id pub-id-type="doi">10.1016/j.nedt.2014.09.009</pub-id> </citation>
</ref>
<ref id="B45">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Shrestha</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Shakya</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Palaian</surname>
<given-names>S.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Clinical Pharmacy Education and Practice in Nepal: A Glimpse into Present Challenges and Potential Solutions</article-title>. <source>Adv. Med. Educ. Pract.</source> <volume>11</volume>, <fpage>541</fpage>&#x2013;<lpage>548</lpage>. <pub-id pub-id-type="doi">10.2147/AMEP.S257351</pub-id> </citation>
</ref>
<ref id="B46">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Siebert</surname>
<given-names>J.&#x20;N.</given-names>
</name>
<name>
<surname>Ehrler</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Gervaix</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Haddad</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>Lacroix</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Schrurs</surname>
<given-names>P.</given-names>
</name>
<etal/>
</person-group> (<year>2017</year>). <article-title>Adherence to AHA Guidelines when Adapted for Augmented Reality Glasses for Assisted Pediatric Cardiopulmonary Resuscitation: A Randomized Controlled Trial</article-title>. <source>J.&#x20;Med. Internet Res.</source> <volume>19</volume> (<issue>5</issue>), <fpage>e183</fpage>. <pub-id pub-id-type="doi">10.2196/jmir.7379</pub-id> </citation>
</ref>
<ref id="B47">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Singh</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>Srivastav</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Bhardwaj</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Dixit</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Misra</surname>
<given-names>S.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Medical Education during the COVID-19 Pandemic: A Single Institution Experience</article-title>. <source>Indian Pediatr.</source> <volume>57</volume> (<issue>7</issue>), <fpage>678</fpage>&#x2013;<lpage>679</lpage>. <pub-id pub-id-type="doi">10.1007/s13312-020-1899-2</pub-id> </citation>
</ref>
<ref id="B48">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Siyar</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Azarnoush</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Rashidi</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Del Maestro</surname>
<given-names>R. F.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Tremor Assessment during Virtual Reality Brain Tumor Resection</article-title>. <source>J.&#x20;Surg. Educ.</source> <volume>77</volume> (<issue>3</issue>), <fpage>643</fpage>&#x2013;<lpage>651</lpage>. <pub-id pub-id-type="doi">10.1016/j.jsurg.2019.11.011</pub-id> </citation>
</ref>
<ref id="B49">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Solbiati</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Passera</surname>
<given-names>K. M.</given-names>
</name>
<name>
<surname>Rotilio</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Oliva</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Marre</surname>
<given-names>I.</given-names>
</name>
<name>
<surname>Goldberg</surname>
<given-names>S. N.</given-names>
</name>
<etal/>
</person-group> (<year>2018</year>). <article-title>Augmented Reality for Interventional Oncology: Proof-Of-Concept Study of a Novel High-End Guidance System Platform</article-title>. <source>Eur. Radiol. Exp.</source> <volume>2</volume>, <fpage>18</fpage>. <pub-id pub-id-type="doi">10.1186/s41747-018-0054-5</pub-id> </citation>
</ref>
<ref id="B50">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Styers</surname>
<given-names>M. L.</given-names>
</name>
<name>
<surname>Van Zandt</surname>
<given-names>P. A.</given-names>
</name>
<name>
<surname>Hayden</surname>
<given-names>K. L.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Active Learning in Flipped Life Science Courses Promotes Development of Critical Thinking Skills</article-title>. <source>CBE Life Sci. Educ.</source> <volume>17</volume> (<issue>3</issue>), <fpage>ar39</fpage>. <pub-id pub-id-type="doi">10.1187/cbe.16-11-0332</pub-id> </citation>
</ref>
<ref id="B51">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Sutherland</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Hashtrudi-Zaad</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>Sellens</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Abolmaesumi</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Mousavi</surname>
<given-names>P.</given-names>
</name>
</person-group> (<year>2013</year>). <article-title>An Augmented Reality Haptic Training Simulator for Spinal Needle Procedures</article-title>. <source>IEEE Trans. Biomed. Eng.</source> <volume>60</volume> (<issue>11</issue>), <fpage>3009</fpage>&#x2013;<lpage>3018</lpage>. <pub-id pub-id-type="doi">10.1109/TBME.2012.2236091</pub-id> </citation>
</ref>
<ref id="B52">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Svensberg</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>Sporrong</surname>
<given-names>S. K.</given-names>
</name>
<name>
<surname>Lupattelli</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Olsson</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Wallman</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Bj&#xf6;rnsdottir</surname>
<given-names>I.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Nordic Pharmacy Students&#x27; Opinions of Their Patient Communication Skills Training</article-title>. <source>Am. J.&#x20;Pharm. Educ.</source> <volume>82</volume> (<issue>2</issue>), <fpage>6208</fpage>. <pub-id pub-id-type="doi">10.5688/ajpe6208</pub-id> </citation>
</ref>
<ref id="B53">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Teramachi</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Ino</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Sugita</surname>
<given-names>I.</given-names>
</name>
<name>
<surname>Nishio</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Yoshida</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Hayashi</surname>
<given-names>Y.</given-names>
</name>
<etal/>
</person-group> (<year>2018</year>). <article-title>Evaluating Communication Skills after Long-Term Practical Training Among Japanese Pharmacy Students</article-title>. <source>Curr. Pharm. Teach. Learn.</source> <volume>10</volume> (<issue>4</issue>), <fpage>446</fpage>&#x2013;<lpage>452</lpage>. <pub-id pub-id-type="doi">10.1016/j.cptl.2017.12.006</pub-id> </citation>
</ref>
<ref id="B54">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Uruthiralingam</surname>
<given-names>U.</given-names>
</name>
<name>
<surname>Rea</surname>
<given-names>P. M.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Augmented and Virtual Reality in Anatomical Education - A Systematic Review</article-title>. <source>Adv. Exp. Med. Biol.</source> <volume>1235</volume>, <fpage>89</fpage>&#x2013;<lpage>101</lpage>. <pub-id pub-id-type="doi">10.1007/978-3-030-37639-0_5</pub-id> </citation>
</ref>
<ref id="B55">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ventola</surname>
<given-names>C. L.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>Virtual Reality in Pharmacy: Opportunities for Clinical, Research, and Educational Applications</article-title>. <source>PT</source> <volume>44</volume> (<issue>5</issue>), <fpage>267</fpage>&#x2013;<lpage>276</lpage>. </citation>
</ref>
<ref id="B56">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wang</surname>
<given-names>L. L.</given-names>
</name>
<name>
<surname>Wu</surname>
<given-names>H. H.</given-names>
</name>
<name>
<surname>Bilici</surname>
<given-names>N.</given-names>
</name>
<name>
<surname>Tenney-Soeiro</surname>
<given-names>R.</given-names>
</name>
</person-group> (<year>2016</year>). <article-title>Gunner Goggles: Implementing Augmented Reality into Medical Education</article-title>. <source>Stud. Health Technol. Inform.</source> <volume>220</volume>, <fpage>446</fpage>&#x2013;<lpage>449</lpage>. </citation>
</ref>
<ref id="B57">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wang</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Parsons</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Stone-McLean</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Rogers</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Boyd</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Hoover</surname>
<given-names>K.</given-names>
</name>
<etal/>
</person-group> (<year>2017</year>). <article-title>Augmented Reality as a Telemedicine Platform for Remote Procedural Training</article-title>. <source>Sensors (Basel)</source> <volume>17</volume> (<issue>10</issue>), <fpage>2294</fpage>. <pub-id pub-id-type="doi">10.3390/s17102294</pub-id> </citation>
</ref>
<ref id="B58">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wartman</surname>
<given-names>S. A.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>The Empirical Challenge of 21st-Century Medical Education</article-title>. <source>Acad. Med.</source> <volume>94</volume> (<issue>10</issue>), <fpage>1412</fpage>&#x2013;<lpage>1415</lpage>. <pub-id pub-id-type="doi">10.1097/ACM.0000000000002866</pub-id> </citation>
</ref>
<ref id="B59">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Yu</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Xie</surname>
<given-names>Z.</given-names>
</name>
<name>
<surname>Yu</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Vazquez-Guardado</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Luan</surname>
<given-names>H.</given-names>
</name>
<etal/>
</person-group> (<year>2019</year>). <article-title>Skin-integrated Wireless Haptic Interfaces for Virtual and Augmented Reality</article-title>. <source>Nature</source> <volume>575</volume> (<issue>7783</issue>), <fpage>473</fpage>&#x2013;<lpage>479</lpage>. <pub-id pub-id-type="doi">10.1038/s41586-019-1687-0</pub-id> </citation>
</ref>
<ref id="B60">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Zgheib</surname>
<given-names>N. K.</given-names>
</name>
<name>
<surname>Simaan</surname>
<given-names>J.&#x20;A.</given-names>
</name>
<name>
<surname>Sabra</surname>
<given-names>R.</given-names>
</name>
</person-group> (<year>2010</year>). <article-title>Using Team-Based Learning to Teach Pharmacology to Second Year Medical Students Improves Student Performance</article-title>. <source>Med. Teach.</source> <volume>32</volume> (<issue>2</issue>), <fpage>130</fpage>&#x2013;<lpage>135</lpage>. <pub-id pub-id-type="doi">10.3109/01421590903548521</pub-id> </citation>
</ref>
<ref id="B61">
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Zhu</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Fors</surname>
<given-names>U.</given-names>
</name>
<name>
<surname>Smedberg</surname>
<given-names>&#xc5;.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Exploring the Needs and Possibilities of Physicians&#x27; Continuing Professional Development - an Explorative Qualitative Study in a Chinese Primary Care Context</article-title>. <source>PloS one</source> <volume>13</volume> (<issue>8</issue>), <fpage>e0202635</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0202635</pub-id> </citation>
</ref>
</ref-list>
</back>
</article>