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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Digit. Health</journal-id>
<journal-title>Frontiers in Digital Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Digit. Health</abbrev-journal-title>
<issn pub-type="epub">2673-253X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fdgth.2023.1060828</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Digital Health</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Empirical networks for localized COVID-19 interventions using WiFi infrastructure at university campuses</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>Das Swain</surname><given-names>Vedant</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/1962671/overview"/></contrib>
<contrib contrib-type="author"><name><surname>Xie</surname><given-names>Jiajia</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib>
<contrib contrib-type="author"><name><surname>Madan</surname><given-names>Maanit</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib>
<contrib contrib-type="author"><name><surname>Sargolzaei</surname><given-names>Sonia</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib>
<contrib contrib-type="author"><name><surname>Cai</surname><given-names>James</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib>
<contrib contrib-type="author"><name><surname>De Choudhury</surname><given-names>Munmun</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib>
<contrib contrib-type="author"><name><surname>Abowd</surname><given-names>Gregory D.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib>
<contrib contrib-type="author"><name><surname>Steimle</surname><given-names>Lauren N.</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/2037985/overview" /></contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Prakash</surname><given-names>B. Aditya</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref><uri xlink:href="https://loop.frontiersin.org/people/938992/overview" /></contrib>
</contrib-group>
<aff id="aff1"><label><sup>1</sup></label><addr-line>College of Computing</addr-line>, <institution>Georgia Institute of Technology</institution>, <addr-line>Atlanta, GA</addr-line>, <country>United States</country></aff>
<aff id="aff2"><label><sup>2</sup></label><addr-line>H. Milton Stewart School of Industrial and Systems Engineering</addr-line>, <institution>Georgia Institute of Technology</institution>, <addr-line>Atlanta, GA</addr-line>, <country>United States</country></aff>
<aff id="aff3"><label><sup>3</sup></label><addr-line>Department of Computer Science</addr-line>, <institution>Brown University</institution>, <addr-line>Providence, RI</addr-line>, <country>United States</country></aff>
<aff id="aff4"><label><sup>4</sup></label><addr-line>College of Engineering</addr-line>, <institution>Northeastern University</institution>, <addr-line>Boston, MA</addr-line>, <country>United States</country></aff>
<author-notes>
<fn fn-type="edited-by"><p><bold>Edited by:</bold> Zahid Butt, University of Waterloo, Canada</p></fn>
<fn fn-type="edited-by"><p><bold>Reviewed by:</bold> Ana Carolina Brisola Brizzi, Anhembi Morumbi University, Brazil, Tiantian Zhang, Fudan University, China</p></fn>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> B. Aditya Prakash <email>badityap@cc.gatech.edu</email></corresp>
</author-notes>
<pub-date pub-type="epub"><day>16</day><month>05</month><year>2023</year></pub-date>
<pub-date pub-type="collection"><year>2023</year></pub-date>
<volume>5</volume><elocation-id>1060828</elocation-id>
<history>
<date date-type="received"><day>03</day><month>10</month><year>2022</year></date>
<date date-type="accepted"><day>12</day><month>04</month><year>2023</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2023 Das Swain, Xie, Madan, Sargolzaei, Cai, De Choudhury, Abowd, Steimle and Prakash.</copyright-statement>
<copyright-year>2023</copyright-year><copyright-holder>Das Swain, Xie, Madan, Sargolzaei, Cai, De Choudhury, Abowd, Steimle and Prakash</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<p>Infectious diseases, like COVID-19, pose serious challenges to university campuses, which typically adopt closure as a non-pharmaceutical intervention to control spread and ensure a gradual return to normalcy. Intervention policies, such as remote instruction (<sans-serif>RI</sans-serif>) where large classes are offered online, reduce potential contact but also have broad side-effects on campus by hampering the local economy, students&#x2019; learning outcomes, and community wellbeing. In this paper, we demonstrate that university policymakers can mitigate these tradeoffs by leveraging anonymized data from their WiFi infrastructure to learn community mobility&#x2014;a methodology we refer to as <italic>WiFi mobility models</italic> (<sc>WiMob</sc>). This approach enables policymakers to explore more granular policies like localized closures (<sans-serif>LC</sans-serif>). <sc>WiMob</sc> can construct contact networks that capture behavior in various spaces, highlighting new potential transmission pathways and temporal variation in contact behavior. Additionally, <sc>WiMob</sc> enables us to design <sans-serif>LC</sans-serif> policies that close super-spreader locations on campus. By simulating disease spread with contact networks from <sc>WiMob</sc>, we find that <sans-serif>LC</sans-serif> maintains the same reduction in cumulative infections as <sans-serif>RI</sans-serif> while showing greater reduction in peak infections and internal transmission. Moreover, <sans-serif>LC</sans-serif> reduces campus burden by closing fewer locations, forcing fewer students into completely online schedules, and requiring no additional isolation. <sc>WiMob</sc> can empower universities to conceive and assess a variety of closure policies to prevent future outbreaks.</p>
</abstract>
<kwd-group>
<kwd>COVID-19</kwd>
<kwd>mobility</kwd>
<kwd>modeling</kwd>
<kwd>policy</kwd>
<kwd>non-pharmaceutical intervention</kwd>
<kwd>WiFi</kwd>
</kwd-group>
<contract-num rid="cn001">CCF-1918770, CAREER IIS-2028586, RAPID IIS-2027862, RAPID IIS-2027689, Medium IIS-1955883, Medium IIS-2106961, NRT DGE-1545362, CCF-2115126, PIPP CCF-2200269</contract-num>
<contract-sponsor id="cn001">NSF</contract-sponsor>
<counts>
<fig-count count="3"/>
<table-count count="2"/><equation-count count="186"/><ref-count count="79"/><page-count count="0"/><word-count count="0"/></counts><custom-meta-wrap><custom-meta><meta-name>section-at-acceptance</meta-name><meta-value>Health Informatics</meta-value></custom-meta></custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1" sec-type="intro"><label>1.</label><title>Introduction</title>
<p>University campuses are often hotspots for infectious disease outbreaks and hence are targeted for interventions. In the wake of the Coronavirus Disease (COVID-19) (<xref ref-type="bibr" rid="B1">1</xref>), the U.S. witnessed more than half a million cases at universities (<xref ref-type="bibr" rid="B2">2</xref>). On the event of infectious disease outbreaks, colleges must make crucial decisions to ensure continuity of operations in safe way (<xref ref-type="bibr" rid="B3">3</xref>,<xref ref-type="bibr" rid="B4">4</xref>). Controlling the disease at universities can be pivotal to securing the surrounding environment (<xref ref-type="bibr" rid="B5">5</xref>). To reduce on-campus infections and the likelihood of superspreading events, a recommended form of non-pharmaceutical intervention (NPI) is partial closure of the campus (<xref ref-type="bibr" rid="B6">6</xref>).</p>
<p>During COVID-19, advancement in teleconferencing technology equips universities to continue operations by adopting a form of campus closure that relies on remote instruction (<sans-serif>RI</sans-serif>) (<xref ref-type="bibr" rid="B7">7</xref>). As a consequence, the campus community has fewer opportunities to visit spaces, such as classrooms, to congregate and risk transmission (<xref ref-type="bibr" rid="B8">8</xref>,<xref ref-type="bibr" rid="B9">9</xref>). One common approach campuses consider to design <sans-serif>RI</sans-serif> policies is to use enrollment data (<sc>En</sc>) to assume contact and therefore, offer large classes online while other classes remain in person (<xref ref-type="bibr" rid="B10">10</xref>,<xref ref-type="bibr" rid="B11">11</xref>). In fact, during COVID-19, 44&#x0025; colleges and universities in the U.S., primarily offered instruction online (<xref ref-type="bibr" rid="B12">12</xref>). However, these policies can still have broad, negative, and indiscriminate impact on the community by forcing students into completely remote course schedules. Such policies can have adverse effect on learning outcomes (<xref ref-type="bibr" rid="B13">13</xref>), where students can lose close to 7 months of education (<xref ref-type="bibr" rid="B14">14</xref>). Additionally, <sans-serif>RI</sans-serif> can disincentivize students to stay on campus and thus, universities incur losses in auxiliary revenue (e.g., boarding, parking, dining, etc.) (<xref ref-type="bibr" rid="B15">15</xref>,<xref ref-type="bibr" rid="B16">16</xref>), with universities standing to lose up to <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM1"><mml:mi mathvariant="normal">&#x0024;</mml:mi><mml:mn>50</mml:mn></mml:math></inline-formula> million because of unused services (<xref ref-type="bibr" rid="B17">17</xref>). Even the local population unaffiliated with the university takes sustains losses to business due to university closures (<xref ref-type="bibr" rid="B18">18</xref>,<xref ref-type="bibr" rid="B19">19</xref>). Furthermore, with socioeconomic disparities and heterogeneous household contexts, the demands of remote instruction can lead to added anxiety and stress among students (<xref ref-type="bibr" rid="B20">20</xref>,<xref ref-type="bibr" rid="B21">21</xref>). Relying on <sans-serif>RI</sans-serif>, university campuses struggle to balance community health with the demands of learning, economy, and broad wellbeing (<xref ref-type="bibr" rid="B22">22</xref>). Instead, there is a need for a more versatile approach to design closure policies that empowers policymakers to accurately assess impact of closure interventions and model more data-driven targeted intervention strategies.</p>
<p>This paper showcases a new approach that universities can take to design closure policies by leveraging data from their existing WiFi infrastructure. Our methodology, <italic>WiFi mobility models</italic> (<sc>WiMob</sc>), involves constructing anonymized mobility networks of campus (<xref ref-type="fig" rid="F1">Figure&#x00A0;1A</xref>), which helps determine extended periods of collocation&#x2014;or &#x201C;proximate contact&#x201D; (<xref ref-type="bibr" rid="B23">23</xref>)&#x2014;between individuals to describe contact networks on campus. Particularly, <sc>WiMob</sc> enables a more expressive toolkit for university policymakers that represents contact longitudinally and allows them to assess closure at the granularity of a room, suite, or hall. Thus, it lends itself to the design of targeted interventions that focus on localized closures (<sans-serif>LC</sans-serif>). We demonstrate the utility of <sc>WiMob</sc> with data collected over two years, of approximately 40,000 anonymous occupants and visitors of the Georgia Institute of Technology (GT), a large urban campus in the U.S.&#x2014;including about 16,000 undergraduate students, 9,000 graduate students, and 7,600 staff members. In general, on comparing <sc>WiMob</sc> to <sc>En</sc> as an approach to model contact, we find that <sc>WiMob</sc> captures contact behavior at a community scale for a variety of campus spaces, describes temporal variations in contact, and provides a better estimate of local context by being aware of occupancy and the non-student population. Using <sc>WiMob</sc> also reveals that <sc>En</sc> overestimates the impact of <sans-serif>RI</sans-serif> on reducing contact on campus. Hence, we propose a less burdensome alternative to <sans-serif>RI</sans-serif>, by deriving more targeted <sans-serif>LC</sans-serif> policies based on <sc>WiMob</sc> (<xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref>) (indeed <sc>En</sc> is too coarse-grained for designing targeted <sans-serif>LC</sans-serif> policies).</p>
<fig id="F1" position="float"><label>Figure 1</label>
<caption><p>The WiFi mobility models (<sc>WiMob</sc>) methodology uses anonymized network logs to model campus mobility for localized closures (<sans-serif>LC</sans-serif>) (<bold>A</bold>) WiFi network logs reflect timestamps when people&#x2019;s devices associate with access points (APs) on campus. <sc>WiMob</sc> mines these logs to characterize mobility as a bipartite graph that describes people (e.g., <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM2"><mml:mi>P</mml:mi><mml:mn>1</mml:mn></mml:math></inline-formula>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM3"><mml:mi>P</mml:mi><mml:mn>2</mml:mn></mml:math></inline-formula>) visiting campus locations (e.g., <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM4"><mml:mi>L</mml:mi><mml:mn>1</mml:mn></mml:math></inline-formula>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM5"><mml:mi>L</mml:mi><mml:mn>2</mml:mn></mml:math></inline-formula>) during different times (e.g., <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM6"><mml:msub><mml:mi>t</mml:mi><mml:mn>1</mml:mn></mml:msub></mml:math></inline-formula>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM7"><mml:msub><mml:mi>t</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:math></inline-formula>). Since people&#x2019;s devices can proxy their presence, we estimate collocation (e.g., <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM8"><mml:mi>P</mml:mi><mml:mn>1</mml:mn></mml:math></inline-formula> and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM9"><mml:mi>P</mml:mi><mml:mn>2</mml:mn></mml:math></inline-formula> were collocated at <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM10"><mml:mi>L</mml:mi><mml:mn>1</mml:mn></mml:math></inline-formula> at <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM11"><mml:msub><mml:mi>t</mml:mi><mml:mn>1</mml:mn></mml:msub></mml:math></inline-formula>), and movement (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM12"><mml:mi>P</mml:mi><mml:mn>2</mml:mn></mml:math></inline-formula> dwelled at <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM13"><mml:mi>L</mml:mi><mml:mn>1</mml:mn></mml:math></inline-formula> and then at <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM14"><mml:mi>L</mml:mi><mml:mn>2</mml:mn></mml:math></inline-formula>). (<bold>B</bold>) We use the collocation network construct a SEIR&#x2013;based epidemiological <sc>ABM</sc>, calibrated to Fall 2020 incidence of COVID-19 (<italic>C</italic>) <sc>WiMob</sc> highlights mobility behavior to evaluate and inform policy. (<bold>C</bold>)&#x2013;<italic>top-left:</italic> Mobility on campus between the top 100 most frequented locations on the GT campus in the Fall semester of 2019. Edges only connect points of significant dwelling and thus do not represent pedestrian routes. (<bold>C</bold>)&#x2013;<italic>top-right:</italic> <sans-serif>RI</sans-serif> is a form of broad closure which affects a large number of students and locations. (<bold>C</bold>)&#x2013;<italic>bottom-right:</italic> By contrast, we propose to use <sc>WiMob</sc> to parsimoniously identify a small set of spreader locations within buildings and design <sans-serif>LC</sans-serif> policies. (<bold>C</bold>)&#x2013;<italic>bottom-left:</italic> We use our epidemiological <sc>ABM</sc> to evaluate these policies under different budgetary constraints and various behavioral scenarios (Persistence, Non-Residential Avoidance, Complete Avoidance). Our study shows that <sans-serif>LC</sans-serif> policies provide equal or better control on the disease spread, and yet minimize the burden on campus compared to <sans-serif>RI</sans-serif>.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fdgth-05-1060828-g001.tif"/>
</fig>
<p>We further exhibit that <sans-serif>LC</sans-serif> presents better disease control outcomes than <sans-serif>RI</sans-serif> by constructing and simulating an agent-based epidemiological model (<sc>ABM</sc>) over the people&#x2013;people contact networks (<xref ref-type="fig" rid="F1">Figure&#x00A0;1B</xref>) derived from the collocation identified with <sc>WiMob</sc> (<xref ref-type="fig" rid="F1">Figure&#x00A0;1A</xref>). Our <sc>ABM</sc> was calibrated with GT on-campus COVID-19 cases from the Fall semester of 2020 (<xref ref-type="bibr" rid="B24">24</xref>) and infection rates from Fulton County (<xref ref-type="bibr" rid="B25">25</xref>). To compare the effect of interventions, we construct a counterfactual semester&#x2014;that is unaltered by other policy&#x2013;induced behaviors of 2020&#x2014;by leveraging WiFi data from Fall 2019 to determine the contact structure of the simulation. We assess the effectiveness of closure NPIs (<xref ref-type="fig" rid="F1">Figure&#x00A0;1C</xref>) by simulating COVID-19 under various behavioral scenarios. We find <sans-serif>LC</sans-serif> is comparable to <sans-serif>RI</sans-serif> in controlling total infections but more effective at reducing the peak infections and internal transmission. Additionally, <sans-serif>LC</sans-serif> targets fewer locations, forces fewer students into fully online schedules, and does not isolate any more people than <sans-serif>RI</sans-serif>&#x2014;illustrating that <sc>WiMob</sc> can help universities devise highly-specific closure policies, like <sans-serif>LC</sans-serif>, which can contain disease spread and mitigate campus disruption in comparison to <sans-serif>RI</sans-serif> policies.</p>
<p>Our methodology also promises other advantages. Mobility generally has been used to dynamically model disease spread of influenza (<xref ref-type="bibr" rid="B26">26</xref>), rubella (<xref ref-type="bibr" rid="B27">27</xref>) and COVID-19 (<xref ref-type="bibr" rid="B9">9</xref>,<xref ref-type="bibr" rid="B28">28</xref>) showing the effectiveness of mobility restrictions at a regional&#x2013;, or city&#x2013;level (<xref ref-type="bibr" rid="B29">29</xref>&#x2013;<xref ref-type="bibr" rid="B33">33</xref>). These studies typically rely on cell tower localization or aggregating GPS information from mobile phones (<xref ref-type="bibr" rid="B34">34</xref>). Neither of these data sources is easy to access for university campuses. At the same time, studies to infer campus mobility networks have relied on accessing user devices with specialized data logging applications (e.g., contact tracing mobile apps) (<xref ref-type="bibr" rid="B35">35</xref>&#x2013;<xref ref-type="bibr" rid="B38">38</xref>), but these approaches are typically constrained for disease modeling because they require mass adoption to represent the entire community and continuous maintenance of software is needed to capture longitudinal behavior changes. In contrast, our work repurposes already existing managed WiFi networks to model mobility, which provides room level granularity for mobility (<xref ref-type="bibr" rid="B39">39</xref>&#x2013;<xref ref-type="bibr" rid="B42">42</xref>) and consequently indicates proximate contact (<xref ref-type="bibr" rid="B23">23</xref>). Much like <sc>En</sc>, universities internally archive such data over a long term for other purposes and do not need to install any additional surveillance infrastructure to access it. Prior work has repurposed such data for campuses of size 10,000&#x2013;50,000 in different locations including Singapore, the U.K., and the U.S (<xref ref-type="bibr" rid="B39">39</xref>,<xref ref-type="bibr" rid="B43">43</xref>). With the appropriate privacy considerations, a university can obtain such data at a low cost, continuously and unobtrusively. The possibility of pandemic still looms large in the future (<xref ref-type="bibr" rid="B44">44</xref>,<xref ref-type="bibr" rid="B45">45</xref>). As campuses prepare for upcoming semestera and unforeseen contagious diseases of tomorrow, <sc>WiMob</sc> presents an attractive and practical method to inform better public health policies.</p>
</sec>
<sec id="s2"><label>2.</label><title>Materials and methods</title>
<p>This section summarizes (i) the data used to derive contact networks and policies, and (ii) the dynamics of our simulation and calibration approach. Additional information for every subsection is present in <xref ref-type="sec" rid="s12">Supplementary Material, Methods</xref>.</p>
<sec id="s2a"><label>2.1.</label><title>WiFi mobility</title>
<p>Here we describe the data for our methodology, WiFi mobility models (<sc>WiMob</sc>) and the process to yield Localized (<sans-serif>LC</sans-serif>) policies.</p>
<sec id="s2a1"><label>2.1.1.</label><title>Data use and access</title>
<p>The IT management facility at Georgia Tech (GT) accumulates WiFi access point logs over time. This is common in most universities with managed WiFi infrastructure. We actively collaborated with IT management to define safety and security safeguards that allow us to obtain a de-identified version of these raw logs. Before accessing the data we established a data-use agreement and an ethics protocol that was approved by the Institutional Review Board (IRB) at Georgia Institute of Technology (Protocol H20208). For the WiFi data, we were provided access to logs from Fall 2019 and Fall 2020. We processed these logs to characterize mobility (<sc>WiMob</sc>) and it encompasses all 40,000 unique visitors that connected to the network via 6,959 different access points (<xref ref-type="bibr" rid="B41">41</xref>). The logs did not contain any personally identifiable information and locations are also coded. The logs indicated the WiFi access point (AP) a device associates with and can therefore be used to infer dwelling locations of users across the entire campus. This is limited to indoor spaces where APs are located and the scope of this localization is at the granularity of a room or suite (<xref ref-type="bibr" rid="B39">39</xref>,<xref ref-type="bibr" rid="B43">43</xref>)). For <sc>En</sc> we only used aggregate insights for enrollment, which were derived from course registration transcripts. Note, we did not cross-identify any students. We used publicly accessible course schedules to approximate schedules of de-identified nodes and infer if they were students or staff, and non-residential or residential. We elaborate on our data in <xref ref-type="sec" rid="s12">Supplementary Material, Data</xref>.</p>
<p><bold>Note.</bold> Like most universities, GT&#x2019;s managed WiFi network is not equipped with any Real-Time Location System (RTLS) (<xref ref-type="bibr" rid="B46">46</xref>,<xref ref-type="bibr" rid="B47">47</xref>). RTLS systems use Received Signal Strength Indicator (RSSI) values from multiple neighboring APs to provide high precise localization of individuals in terms of time and space. However, deploying such systems requires surveying the entire network. Additionally, precision localization raises more privacy concerns. These factors together make it challenging for universities to justify the deployment of RTLS, unlike small retail settings that can monetize RTLS insights directly (e.g., insights on footfall can be tied to improving revenue).</p>
</sec>
<sec id="s2a2"><label>2.1.2.</label><title>Contact and movement networks</title>
<p><sc>WiMob</sc> leverages the logs to create bipartite graphs <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM15"><mml:msub><mml:mi>K</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula>, for each day <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM16"><mml:mi>t</mml:mi></mml:math></inline-formula>, which connect <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM17"><mml:mi>P</mml:mi></mml:math></inline-formula> users to <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM18"><mml:mi>L</mml:mi></mml:math></inline-formula> access point locations (<xref ref-type="fig" rid="F1">Figure&#x00A0;1A</xref>). Any edge, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM19"><mml:mo fence="false" stretchy="false">{</mml:mo><mml:mi>p</mml:mi><mml:mo>,</mml:mo><mml:mi>l</mml:mi><mml:msub><mml:mo fence="false" stretchy="false">}</mml:mo><mml:mi>i</mml:mi></mml:msub></mml:math></inline-formula> indicates the <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM20"><mml:mi>i</mml:mi></mml:math></inline-formula>th instance when a <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM21"><mml:mi>p</mml:mi></mml:math></inline-formula> was dwelling at <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM22"><mml:mi>l</mml:mi></mml:math></inline-formula>. These edges describe the time period of dwelling. Subsequently, by comparing all edges in <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM23"><mml:msub><mml:mi>K</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> we can infer if different individuals are collocated near an AP to create a contact network, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM24"><mml:msub><mml:mi>G</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula>, for each day <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM25"><mml:mi>t</mml:mi></mml:math></inline-formula>&#x2014;between any collocated <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM26"><mml:msub><mml:mi>p</mml:mi><mml:mi>i</mml:mi></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>p</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>&#x2208;</mml:mo><mml:mi>P</mml:mi></mml:math></inline-formula>. These networks define the contact structure for an epidemiological agent-based model at every time-step. Similarly, by inspecting the sequence of dwelling locations for any <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM27"><mml:mi>p</mml:mi></mml:math></inline-formula> in graph <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM28"><mml:mi>K</mml:mi></mml:math></inline-formula>, we compute a mobility network, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM29"><mml:msub><mml:mi>H</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula>&#x2014;between locations <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM30"><mml:mi>l</mml:mi><mml:mo>&#x2208;</mml:mo><mml:mi>L</mml:mi></mml:math></inline-formula>. In our approach, we considered collocation as a form of <italic>proximate contact</italic>&#x2014;people in the same room&#x2014;and therefore established collocation only when this occurred for &#x201C;an extended period&#x201D; (<xref ref-type="bibr" rid="B23">23</xref>). By varying this threshold between <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM31"><mml:mn>30</mml:mn></mml:math></inline-formula> and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM32"><mml:mn>40</mml:mn></mml:math></inline-formula> minutes we found the contact networks to be structurally similar as their clustering coefficients (over the semester) were highly correlated (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM33"><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.97</mml:mn></mml:math></inline-formula>). In our experiments, we used the <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM34"><mml:mn>40</mml:mn></mml:math></inline-formula> minute threshold as it was more computationally less expensive. We provide more details of our approach in <xref ref-type="sec" rid="s12">Supplementary Material, Data Processing</xref> and in <xref ref-type="sec" rid="s12">Supplementary Material, Modeling Contact and Movement</xref>.</p>
</sec>
<sec id="s2a3"><label>2.1.3.</label><title>Modeling policies</title>
<p>We compared the disease outcomes and burdens of 2 policies, Remote Instruction (<sans-serif>RI</sans-serif>) and Localized Closure (<sans-serif>LC</sans-serif>), both of which are modeled with <sc>WiMob</sc>.
<list list-type="simple">
<list-item>
<p><bold>Remote Instruction (<sans-serif>RI</sans-serif>):</bold> The status quo for data-driven policies offers strictly online instruction for large class enrollment, while continuing the other classes in person. When using <sc>En</sc> to model contacts, we implemented <sans-serif>RI</sans-serif> by removing connections between students who were only in contact through courses of size <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM35"><mml:mo>&#x2265;</mml:mo></mml:math></inline-formula>30. When using <sc>WiMob</sc> to model contacts, we removed connections between students if they were only connected because of collocations during scheduled lectures of such courses.</p></list-item>
<list-item>
<p><bold>Localized Closure (<sans-serif>LC</sans-serif>):</bold> We identified rooms&#x2013;level spaces that are highly central location nodes in the network. We removed contacts between people who are only connected because of collocating at these locations.</p></list-item>
</list></p>
<p>To further elaborate, for <sans-serif>RI</sans-serif> we inferred enrollment size of each course in Fall 2019 by determining the number of unique individuals that visited lecture locations during scheduled times. After the first week, we applied the <sans-serif>RI</sans-serif> by removing all visiting edges in <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM36"><mml:msub><mml:mi>K</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> for any <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM37"><mml:msub><mml:mi>l</mml:mi><mml:mi>c</mml:mi></mml:msub><mml:mo>&#x2208;</mml:mo><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mtext>RI&#xA0;</mml:mtext></mml:mrow></mml:msub></mml:math></inline-formula> if visits were during lecture times of course <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM38"><mml:mi>c</mml:mi></mml:math></inline-formula> with an enrollment <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM39"><mml:mo>&#x2265;</mml:mo></mml:math></inline-formula>30. This helped create counterfactual contact networks <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM40"><mml:msubsup><mml:mi>G</mml:mi><mml:mi>t</mml:mi><mml:mo>&#x2032;</mml:mo></mml:msubsup></mml:math></inline-formula>. The removal of edges from <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM41"><mml:mi>K</mml:mi></mml:math></inline-formula> described the mobility budget of <sans-serif>RI</sans-serif> and the structure of <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM42"><mml:msubsup><mml:mi>G</mml:mi><mml:mi>t</mml:mi><mml:mo>&#x2032;</mml:mo></mml:msubsup></mml:math></inline-formula> indicated the risk of exposure budget. We designed <sans-serif>LC</sans-serif> with these budgets by identifying locations for closure (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM43"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mtext>LC&#xA0;</mml:mtext></mml:mrow></mml:msub></mml:math></inline-formula>) with different algorithms, such as <italic>PageRank (<xref ref-type="bibr" rid="B48">48</xref>), Eigenvector Centrality (<xref ref-type="bibr" rid="B49">49</xref>), Load Centrality (<xref ref-type="bibr" rid="B50">50</xref>), and Betweenness Centrality (<xref ref-type="bibr" rid="B51">51</xref>)</italic>. When a location was closed, we removed all edges in <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM44"><mml:msub><mml:mi>K</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> connected to any <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM45"><mml:msub><mml:mi>l</mml:mi><mml:mi>x</mml:mi></mml:msub><mml:mo>&#x2208;</mml:mo><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mtext>LC&#xA0;</mml:mtext></mml:mrow></mml:msub></mml:math></inline-formula>. We aggregated the movement graph <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM46"><mml:msub><mml:mi>H</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> over a week and apply the algorithms to identify locations. Subsequently, we identified the number of top-ranked locations to remove such that the resultant counterfactual contact network <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM47"><mml:msubsup><mml:mi>G</mml:mi><mml:mi>t</mml:mi><mml:mo>&#x2033;</mml:mo></mml:msubsup></mml:math></inline-formula> has is within <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM48"><mml:mn>1</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of the budget. More details for closure policies have been expanded in <xref ref-type="sec" rid="s12">Supplementary Material, Identifying Locations for Closure</xref>.</p>
<p>To make the comparisons between the closure policies, we established fixed budgets to design <sans-serif>LC</sans-serif> based on the resource utilization on <sans-serif>RI</sans-serif>. We considered 2 kinds of budgets, (i) mobility reduction&#x2014;to depict space use on campus, and (ii) risk of exposure&#x2014;to reflect testing capacity. Also note, response to closure policies can lead to unpredictable side-effects in campus behavior, particularly when a student&#x2019;s schedule is entirely online. Therefore, we design policies within three behavioral scenarios (each with a varying budget):
<list list-type="simple">
<list-item>
<p><italic>[S1] Persistence</italic>: Irrespective of the locations closed or classes restricted, individuals continue their other visiting behaviors.</p></list-item>
<list-item>
<p><italic>[S2] Non-Residential Avoidance</italic>: Non-residential students stop all visits to campus if they enrolled in at least 3 courses and the policy forces their entire academic schedule online.</p></list-item>
<list-item>
<p><italic>[S3] Complete Avoidance</italic>: Same as S2, but even residential students avoid campus based on their schedule.</p></list-item>
</list></p>
<p>The budgets varied for different behavioral scenarios and we only compared policies within the same scenario. Similar to other works that model closure (<xref ref-type="bibr" rid="B11">11</xref>,<xref ref-type="bibr" rid="B52">52</xref>), we assume that when a location is shutdown, the individuals who ought to have visited that location isolated during the time. This is further elaborated in <xref ref-type="sec" rid="s12">Supplementary Material, Modeling Policies and Scenarios</xref>.</p>
</sec>
</sec>
<sec id="s2b"><label>2.2.</label><title>Disease simulation</title>
<p>Here we summarize our epidemiological model and calibration process.</p>
<sec id="s2b1"><label>2.2.1.</label><title>Agent-based model</title>
<p>We constructed an agent-based model (<sc>ABM</sc>) that captures the spread of COVID-19 between individuals active on campus. This ABM leveraged the contact networks produced by <sc>WiMob</sc>. The simulation iterated a time-step each day with the underlying contact networks i.e., <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM49"><mml:msub><mml:mi>G</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> for no interventions, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM50"><mml:msubsup><mml:mi>G</mml:mi><mml:mi>t</mml:mi><mml:mo>&#x2032;</mml:mo></mml:msubsup></mml:math></inline-formula> for <sans-serif>RI</sans-serif>, and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM51"><mml:msubsup><mml:mi>G</mml:mi><mml:mi>t</mml:mi><mml:mo>&#x2033;</mml:mo></mml:msubsup></mml:math></inline-formula> for <sans-serif>LC</sans-serif>. Each agent in our <sc>ABM</sc> follows a modified version of <italic>susceptible&#x2013;exposed&#x2013;infectious&#x2013;removed</italic> (SEIR) template that disambiguates the <italic>infectious</italic> compartment into <italic>asymptomatic</italic> and <italic>symptomatic</italic>. New infections were introduced to the model either externally or internally. External transmission arose because individuals could contract the virus outside campus and bring the infection back for local spread (<xref ref-type="bibr" rid="B7">7</xref>,<xref ref-type="bibr" rid="B53">53</xref>). We adopted data of positive cases from Fulton county (<xref ref-type="bibr" rid="B25">25</xref>) with a scaling factor <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM52"><mml:mi>&#x03B1;</mml:mi></mml:math></inline-formula> to estimate the probability that a <italic>susceptible</italic> individual, who is active on campus, was infected from interactions that take place outside campus. Internal transmissions are determined by <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM53"><mml:mi>p</mml:mi></mml:math></inline-formula>, as the probability of <italic>susceptible</italic> individuals in contact with an <italic>infectious</italic> one. We calibrated the parameters related to disease transmission by training and validating our models on the positivity rate reported by GT surveillance testing (<xref ref-type="bibr" rid="B24">24</xref>). <xref ref-type="sec" rid="s12">Supplementary Material, Agent-Based Model</xref> details the disease progression and describes the various parameters.</p>
</sec>
<sec id="s2b2"><label>2.2.2.</label><title>Calibration</title>
<p>In our study, we estimated three key parameters: (i) infectious individuals at day 0, (ii) transmission probability between infectious and susceptible individuals, and (iii) the probability of infection transmission from contacts outside the network. We estimated the range of optimal parameters for disease transmission by minimizing the root means square error (r.m.s.e) between the Georgia Tech surveillance testing positive rates (<xref ref-type="bibr" rid="B24">24</xref>,<xref ref-type="bibr" rid="B54">54</xref>) and the observed positivity rate of the model every week&#x2014;percentage of new <italic>asymptomatic</italic> cases out of the total testable population. The surveillance testing conducted by Georgia Tech was designed for detecting individuals who contracted Covid-19 without showing Flu-like symptoms within the community (<xref ref-type="bibr" rid="B54">54</xref>). We calibrated the model on the positivity rates on the first <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM54"><mml:mn>5</mml:mn></mml:math></inline-formula> weeks of Fall 2020. To attain a point estimation of the optimal parameters, we fitted the model to predict trends in the remaining weeks by running a numerical optimization algorithm, Nelder-Mead (<xref ref-type="bibr" rid="B55">55</xref>). To account for quantitative uncertainty, we estimated a range of parameters, within <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM55"><mml:mn>40</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of optimum r.m.s.e (<xref ref-type="bibr" rid="B30">30</xref>). For other model parameters, we adopted values proposed by previous studies on similar populations (<xref ref-type="bibr" rid="B56">56</xref>&#x2013;<xref ref-type="bibr" rid="B58">58</xref>). <xref ref-type="table" rid="T1">Table&#x00A0;1</xref> shows a full list of our parameters.</p>
<table-wrap id="T1" position="float"><label>Table 1</label>
<caption><p>Model parameters of the <sc>ABM</sc>.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="left"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Parameter</th>
<th valign="top" align="center">Definition</th>
<th valign="top" align="center">Value</th>
<th valign="top" align="center">Std</th>
<th valign="top" align="center">Source</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM56"><mml:mi>p</mml:mi></mml:math></inline-formula></td>
<td valign="top" align="left">Transmission probability: For any edge between a <italic>susceptible</italic> and <italic>infectious</italic> individual in the contact network, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM57"><mml:mi>p</mml:mi></mml:math></inline-formula> is the probability that the <italic>susceptible</italic> person will enter into the <italic>exposed</italic> state. This only dictates internal transmission</td>
<td valign="top" align="center">0.034</td>
<td valign="top" align="center">0.007</td>
<td valign="top" align="center">Calibration</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM58"><mml:mi>&#x03B1;</mml:mi></mml:math></inline-formula></td>
<td valign="top" align="left">Scaling factor of the normalized confirmed cases in the surrounding county (<xref ref-type="sec" rid="s12">S1</xref>). This is the parameter for us to generate <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM59"><mml:msub><mml:mi>I</mml:mi><mml:mrow><mml:mi>o</mml:mi><mml:mi>u</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:mi>t</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:math></inline-formula></td>
<td valign="top" align="center">0.032</td>
<td valign="top" align="center">0.0032</td>
<td valign="top" align="center">Calibration</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM60"><mml:msub><mml:mi>I</mml:mi><mml:mrow><mml:mn>0</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula></td>
<td valign="top" align="left">Proportion of population that is <italic>asymptomatic</italic> at day <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM61"><mml:mn>0</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center">0.012</td>
<td valign="top" align="center">0.0009</td>
<td valign="top" align="center">Calibration</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM62"><mml:msub><mml:mi>p</mml:mi><mml:mrow><mml:mi>S</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula></td>
<td valign="top" align="left">Probability of <italic>exposed</italic> persons becoming symptomatic</td>
<td valign="top" align="center">0.66</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">(<xref ref-type="bibr" rid="B56">56</xref>)</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM63"><mml:msub><mml:mi mathvariant="normal">&#x0394;</mml:mi><mml:mrow><mml:mi>S</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula></td>
<td valign="top" align="left">Incubation period (days) since the first day of exposure</td>
<td valign="top" align="center">5</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">(<xref ref-type="bibr" rid="B56">56</xref>)</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM64"><mml:msub><mml:mi mathvariant="normal">&#x0394;</mml:mi><mml:mrow><mml:mtext>Asym</mml:mtext><mml:mo stretchy="false">&#x2192;</mml:mo><mml:mi>R</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula></td>
<td valign="top" align="left">Asymptomatic duration (days); it is the time taken for an <italic>asymptomatic</italic> person to recover since the first day of exposure</td>
<td valign="top" align="center">7</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">(<xref ref-type="bibr" rid="B56">56</xref>)</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM65"><mml:msub><mml:mi mathvariant="normal">&#x0394;</mml:mi><mml:mrow><mml:mi>I</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM66"><mml:msub><mml:mi>&#x03C3;</mml:mi><mml:mrow><mml:mi>I</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula></td>
<td valign="top" align="left">Time of an <italic>symptomatic</italic> entering <italic>isolated</italic> since the first day of exposure of a <italic>symptomatic</italic> person</td>
<td valign="top" align="center">8</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">(<xref ref-type="bibr" rid="B57">57</xref>)</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM67"><mml:msub><mml:mi mathvariant="normal">&#x0394;</mml:mi><mml:mrow><mml:mi>R</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM68"><mml:msub><mml:mi>&#x03C3;</mml:mi><mml:mrow><mml:mi>R</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula></td>
<td valign="top" align="left">Time for recovery for a <italic>symptomatic</italic>, since the first day of exposure</td>
<td valign="top" align="center">12</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">(<xref ref-type="bibr" rid="B58">58</xref>)</td>
</tr>
<tr>
<td valign="top" align="left"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM69"><mml:msub><mml:mi>p</mml:mi><mml:mrow><mml:mi>D</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula></td>
<td valign="top" align="left">Death rate under isolation</td>
<td valign="top" align="center">0.0006</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">(<xref ref-type="bibr" rid="B58">58</xref>)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table-fn1"><p>The variables <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM70"><mml:mi>p</mml:mi></mml:math></inline-formula>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM71"><mml:mi>&#x03B1;</mml:mi></mml:math></inline-formula>, and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM72"><mml:msub><mml:mi>I</mml:mi><mml:mrow><mml:mn>0</mml:mn></mml:mrow></mml:msub></mml:math></inline-formula> are estimated by calibrating the simulation model on the first <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM73"><mml:mn>5</mml:mn></mml:math></inline-formula> weeks of positivity rates provided by GT surveillance for Fall 2020, while incorporating external cases from Fulton County. These parameters were found by validating the <sc>ABM</sc> on the remaining weeks of Fall 2020. <xref ref-type="sec" rid="s12">Supplementary Material, Calibration</xref> provides additional details.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>Note that our calibration characterized latent factors associated with pandemic-related cautious behaviors, including the relationship with external transmission. And these factors could be related to &#x201C;county characteristics, partisanship, media consumption, and racial and ethnic composition&#x201D; (<xref ref-type="bibr" rid="B8">8</xref>). To account for the effect of these varying latent factors on disease outcomes, we performed additional calibrations for hypothetical variations in disease spread. For these analyses we kept the GT mobility behavior constant while calibrating the model on different time periods of surveillance testing and on positivity rates of different U.S. universities&#x2014;University of Illinois at Urbana-Champaign (<xref ref-type="bibr" rid="B59">59</xref>) and University of California (<xref ref-type="bibr" rid="B60">60</xref>), Berkeley. We evaluated <sans-serif>RI</sans-serif> and <sans-serif>LC</sans-serif> on these variations and describe the design of these complementary experiments in <xref ref-type="sec" rid="s12">Supplementary Material, Sensitivity Analyses</xref>. See <xref ref-type="sec" rid="s12">Supplementary Material, Calibration</xref> for details on the calibration process and results of all variations are in <xref ref-type="sec" rid="s12">Table S3</xref>.</p>
</sec>
</sec>
</sec>
<sec id="s3" sec-type="results"><label>3.</label><title>Results</title>
<p>We present two sets of analyses in our work. The first set contrasts structural characteristics of contact networks described by <sc>WiMob</sc> with current practices that use enrollment data (<sc>En</sc>). In the next set, we used <sc>WiMob</sc> to build an epidemiological model (an agent-based model over the contact networks, referred to as <sc>ABM</sc>) and analyze the remote instruction (<sans-serif>RI</sans-serif>) and localized closure (<sans-serif>LC</sans-serif>) interventions in terms of their differences in dynamic disease-control outcomes and burdens to campus.</p>
<p>Note, throughout the paper we use the small-caps to denote different methodologies to model contact (<sc>WiMob</sc> and <sc>En</sc>) and sans-serif to denote different intervention strategies (<sans-serif>RI</sans-serif> and <sans-serif>LC</sans-serif>).</p>
<sec id="s3a"><label>3.1.</label><title><sc>WiMob</sc> provides local, holistic and dynamic structural insights for contact networks on campus</title>
<p>Studies on <sans-serif>RI</sans-serif> policies tend to assume that contact in universities is largely informed by <sc>En</sc>&#x2014;transcripts showing which courses a student is registered for, or &#x201C;enrolled&#x201D; into. <sc>En</sc> can provide structural insights on density of connections and disease transmission paths to inform modeling disease simulations (<xref ref-type="bibr" rid="B61">61</xref>). However, such static data can overestimate attendance and ignore overlap between courses (via instructors) and organic interactions outside classes (e.g., waiting areas, dining, parties, and extra-curricular activities). Therefore, using <sc>En</sc> can overemphasize the disease-mitigating structural changes to the network by <sans-serif>RI</sans-serif> interventions. By contrast, <sc>WiMob</sc> is more grounded in community behavior as it captures multiple scheduled and serendipitous contact situations dynamically over the semester. We compared the features of contact networks constructed with <sc>WiMob</sc>, against networks constructed with <sc>En</sc> using data from GT for Fall semester of 2019 (August 19&#x2013;December 14), prior to any COVID-19 reported cases in the U.S. <sc>En</sc> approximates contact based on students enrolling for classes that could potentially collocate them in the same room during lectures. <sc>WiMob</sc> infers contact when any two individuals actually collocate near the same WiFi access point (<xref ref-type="bibr" rid="B41">41</xref>,<xref ref-type="bibr" rid="B42">42</xref>) for extended period (see explanation in <xref ref-type="sec" rid="s12">Supplementary Material, WiFi Mobility</xref>). We found that <sc>WiMob</sc> rendered new insight into contact on campus that was invisible to the <sc>En</sc> methodology.</p>
<sec id="s3a1"><label>3.1.1.</label><title><sc>WiMob</sc> characterizes temporal variation in proximity</title>
<p>Variation in contact over the semester would naturally impact the severity of disease spread. However, <sc>En</sc> describes a static network that does not capture such dynamics (<xref ref-type="fig" rid="F2">Figure&#x00A0;2A</xref>). Instead, we found that <sc>WiMob</sc> shows contacts got sparser over the semester. <xref ref-type="fig" rid="F2">Figure&#x00A0;2C</xref> presents a notable decline in contacts after the first two weeks, which coincides with multiple orientation seminars and the so-called &#x201C;course shopping&#x201D; period of Fall 2019. In fact, contact decreased considerably in classrooms, with a steeper slope possibly because of reduction in attendance. <sc>WiMob</sc> was able to reveal other observable changes, such as drop in contacts during exam period (week <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM74"><mml:mn>15</mml:mn></mml:math></inline-formula>) and increase after fall recess (week <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM75"><mml:mn>10</mml:mn></mml:math></inline-formula>). <sc>En</sc> rendered a highly connected static network, which can miscalculate the speed at which a disease spreads. By contrast, the longitudinal behavior represented by <sc>WiMob</sc> can help universities anticipate disease spread more accurately.</p>
<fig id="F2" position="float"><label>Figure 2</label>
<caption><p>Results show difference in structural characteristics of contact networks from <sc>En</sc> (course enrollment) and <sc>WiMob</sc> (campus mobility). (<bold>A</bold>) In general, <sc>En</sc> overestimates connections (grey edges) between students (green nodes) and does not anticipate changes through the semester. <sc>En</sc> assumes <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM76"><mml:mn>90</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of students to be connected in a single component, but <sc>WiMob</sc> reveals (red edges) that on any given week only 69&#x0025; are in the largest component (those not on campus are isolated and shown in the circumference). Moreover, <sc>WiMob</sc> reveals that density of connections changes over the semester. (<bold>B</bold>) <sc>En</sc> depicts campus contacts to be connected closely into a &#x201C;small world.&#x201D; <sc>WiMob</sc> shows that contacts evolve over time. As mobility captures interactions outside classrooms we observe that for the first <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM77"><mml:mn>6</mml:mn></mml:math></inline-formula> weeks the shortest transmission path between people is shorter than what is reported by <sc>En</sc>. (<bold>C</bold>) Enrolling into a course does not necessitate physically collocating with the class for extended periods (students can also choose to be entirely absent). <sc>WiMob</sc> reflects this behavior and highlights a decline in average contacts over time. (<bold>D</bold>) These structural differences can help policymakers anticipate the effect of closure policies by describing how it fragments the underlying contact network. <sc>En</sc> shows that remote instruction leads to a <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM78"><mml:mn>94</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> reduction in contacts and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM79"><mml:mn>50</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> increase in transmission path length (similar to numbers reported in prior work (<xref ref-type="bibr" rid="B11">11</xref>), shown as <sc>En</sc> (Ext.)). However, the estimate is significantly lower when measured using <sc>WiMob</sc>. As a result, <sc>WiMob</sc> emphasizes the limits of remote instruction policies and in turn motivates new policies that can be designed and evaluated with actual on-campus behavior.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fdgth-05-1060828-g002.tif"/>
</fig>
</sec>
<sec id="s3a2"><label>3.1.2.</label><title><sc>En</sc> overestimates contact-based risk</title>
<p>Campuses can assess risk of an outbreak by characterizing the number of individuals that would be at risk of infection through contact. In our study, <sc>En</sc> indicated <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM80"><mml:mn>99</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of the individuals on campus were clustered in a single component&#x2014;if any of them would have been infected in Fall 2019, the entire component would be at risk. From the lens of <sc>En</sc> a virus can exhaust an entire population with infection very early. However, <sc>WiMob</sc> showed that only <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM81"><mml:mn>69</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of the population was connected in a single component (<xref ref-type="sec" rid="s12">Table S2</xref>). This difference is because <sc>WiMob</sc> can distinguish how many individuals are active on campus. Therefore, <sc>WiMob</sc> provides a pragmatic estimate of risk by grounding it in local occupancy and helps campuses budget for resources better.</p>
</sec>
<sec id="s3a3"><label>3.1.3.</label><title><sc>WiMob</sc> reveals different paths for disease transmission</title>
<p>Reports suggest that a key contributor to cases in the pandemic is actually clustering of individuals in non-academic spaces (<xref ref-type="bibr" rid="B7">7</xref>). However, <sc>En</sc> does not depict a holistic view of campus contact. It is limited to classrooms and, therefore, fixates on contacts in lectures, while ignoring other spaces. In fact, <sc>WiMob</sc> showed that in the first <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM82"><mml:mn>6</mml:mn></mml:math></inline-formula> weeks of Fall 2019, the shortest path among individuals was smaller than that approximated by <sc>En</sc> (<xref ref-type="fig" rid="F2">Figure&#x00A0;2B</xref>). With <sc>WiMob</sc>, we observed new paths in the contact network from situations outside classes. On a given week, <sc>WiMob</sc> showed the average shortest path with contact is <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM83"><mml:mn>3.26</mml:mn><mml:mo stretchy="false">(</mml:mo><mml:mo>&#x00B1;</mml:mo><mml:mn>0.5</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:math></inline-formula> when only considering lectures, whereas capturing all contexts reduced the average shortest path to <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM84"><mml:mn>2.67</mml:mn><mml:mo stretchy="false">(</mml:mo><mml:mo>&#x00B1;</mml:mo><mml:mn>0.28</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:math></inline-formula>. Characterizing shorter pathways is crucial for policymakers as closure policies by design aim to disconnect these pathways.</p>
</sec>
<sec id="s3a4"><label>3.1.4.</label><title><sc>En</sc> overemphasizes the impact of remote instruction</title>
<p>Prior work uses <sc>En</sc> to posit that <sans-serif>RI</sans-serif> reduces contact and in turn significantly fragments the network for disease spread in universities (<xref ref-type="bibr" rid="B10">10</xref>,<xref ref-type="bibr" rid="B11">11</xref>). We evaluated the effectiveness of such a policy if it were applied in Fall 2019, with both <sc>WiMob</sc> and <sc>En</sc>. <xref ref-type="fig" rid="F2">Figure&#x00A0;2D</xref> shows that <sans-serif>RI</sans-serif> with <sc>En</sc> reduced contact by <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM85"><mml:mn>94</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> and increases shortest path by <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM86"><mml:mn>50</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>. However, the same intervention with <sc>WiMob</sc> showed a relatively milder impact (contact reduction <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM87"><mml:mn>45</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>; shortest path increase <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM88"><mml:mn>11</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>). This reinforces that contact outside courses are significant and remain unaffected by enrollment-oriented policies like <sans-serif>RI</sans-serif>. <sc>WiMob</sc> provides a more encompassing view of the structural effects to a network and motivates design of more impactful closure policies.</p>
</sec>
</sec>
<sec id="s3b"><label>3.2.</label><title>Epidemiological model built with <sc>WiMob</sc> shows that <sans-serif>LC</sans-serif> yields better infection reduction with lower burden</title>
<p>As outlined above, <sc>En</sc> does not comprehensively capture the contact on campus. By contrast, contact networks built with <sc>WiMob</sc> demonstrate new structural insights, which are critical to describe disease spread. A campus is composed of many different spaces, and <sc>En</sc> does not have the flexibility to design closure of such spaces or assess its impact. These drawbacks naturally motivate a new approach to design interventions. Since <sc>WiMob</sc> mitigates the limitations of <sc>En</sc>, we leveraged it to demonstrate the effectiveness of localized closure (<sans-serif>LC</sans-serif>) policies.</p>
<p>We used <sc>WiMob</sc> to define the contact structure of each day and simulate COVID-19 with an agent-based model. Our <sc>ABM</sc> was overlayed by a modified SEIR compartmental model for COVID-19 for each agent. GT also had implemented a robust surveillance program on campus. Hence we calibrated the <sc>ABM</sc> on the positivity rate for COVID-19 for GT (<xref ref-type="bibr" rid="B24">24</xref>) in the first <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM89"><mml:mn>5</mml:mn></mml:math></inline-formula> weeks of Fall 2020 also incorporating external seeding from the surrounding Fulton County, GA (<xref ref-type="bibr" rid="B25">25</xref>). We validated our model by predicting future trends for the rest of Fall 2020. For robustness, we performed additional calibrations by varying time windows and university context (details in <xref ref-type="sec" rid="s12">Supplementary Material, Sensitivity Analyses</xref>). We studied interventions by applying the <sc>ABM</sc> over the contact networks produced by <sc>WiMob</sc> with data from Fall 2019&#x2014;a counterfactual to Fall 2020 if no closure had occurred (see <xref ref-type="sec" rid="s12">Supplementary Material, Simulation Model</xref> for further details). The results in the main article refer to <sans-serif>LC</sans-serif> policies derived using <italic>PageRank</italic> (<xref ref-type="bibr" rid="B48">48</xref>). The corresponding results for other centrality algorithms are available in the Supplementary Information.</p>
<sec id="s3b1"><label>3.2.1.</label><title><sc>WiMob</sc> can model <sans-serif>RI</sans-serif> and <sans-serif>LC</sans-serif> interventions with various configurations</title>
<p>Prior works show a few locations are responsible for majority spread (<xref ref-type="bibr" rid="B30">30</xref>) and restricting movement between them leads to greater control (<xref ref-type="bibr" rid="B62">62</xref>). We found that, if COVID-19 spread through Fall 2019 (a regular semester), the cases rose after <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM90"><mml:mn>7</mml:mn></mml:math></inline-formula>&#x00A0;days (<xref ref-type="fig" rid="F3">Figure&#x00A0;3A</xref>). Therefore, we applied both <sans-serif>RI</sans-serif> and <sans-serif>LC</sans-serif> interventions after the first week. To devise interventions, <sc>WiMob</sc> estimated how <sans-serif>RI</sans-serif> uses the budget and then designed <sans-serif>LC</sans-serif> to match this budget under every behavioral scenario. <xref ref-type="table" rid="T2">Table&#x00A0;2</xref> describes how the budget for each policy varies. Additional details are present in <xref ref-type="sec" rid="s12">Supplementary Material, Modeling Policy and Scenarios</xref>.</p>
<fig id="F3" position="float"><label>Figure 3</label>
<caption><p>Results of policy interventions with our calibrated <sc>ABM</sc> on contact networks from Fall 2019, derived from <sc>WiMob</sc> (<bold>A</bold>) This graph compares the mean active infections between <sans-serif>LC</sans-serif> and <sans-serif>RI</sans-serif>. <sans-serif>LC</sans-serif> show improved outcomes (shaded regions) even when constrained to the same restrictions of <sans-serif>RI</sans-serif> policies. (<bold>a</bold>)&#x2013;<italic>inset:</italic> After the first wave, even though <sans-serif>LC</sans-serif> shows slightly higher active infections, the cumulative infections are still lower, especially those that are a result of internal transmission on campus. <xref ref-type="sec" rid="s12">Figures S10&#x2013;S17</xref> show changes in cumulative infections under different policies, including <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM91"><mml:mn>2.5</mml:mn></mml:math></inline-formula>th and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM92"><mml:mn>97.5</mml:mn></mml:math></inline-formula>th percentile intervals. (<bold>B</bold>) Outcomes of policies within the same behavioral scenario are shown with boxes of the same color (<sans-serif>RI</sans-serif> policies are solid, <sans-serif>LC</sans-serif> policies are hatched) and box heights represent the <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM93"><mml:mn>2.5</mml:mn></mml:math></inline-formula>th and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM94"><mml:mn>97.5</mml:mn></mml:math></inline-formula>th percentile. In <italic>S1</italic>, even though <sans-serif>LC</sans-serif> and <sans-serif>RI</sans-serif> are equally burdensome in terms of students avoiding campus, <sans-serif>LC</sans-serif> shows improved outcome on peak reductions. In fact, for the other scenarios, <sans-serif>LC</sans-serif> shows better outcomes than <sans-serif>RI</sans-serif>, without forcing as many students into online schedules, and, therefore, being even less burdensome with greater impact. <xref ref-type="sec" rid="s12">Figure S6&#x2013;S9</xref> show comparison of all policy outcomes with different budgets.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fdgth-05-1060828-g003.tif"/>
</fig>
<table-wrap id="T2" position="float"><label>Table 2</label>
<caption><p>Comparison of policies in terms of controlling the disease and impacts on campus in Fall 2019.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Behavioral scenario</th>
<th valign="top" align="center" colspan="3">S1: Persistence</th>
<th valign="top" align="center" colspan="3">S2: Non-res avoidance</th>
<th valign="top" align="center" colspan="3">S3: Complete avoidance</th>
</tr>
<tr>
<th valign="top" align="left">Policy</th>
<th valign="top" align="center"><sans-serif>RI</sans-serif></th>
<th valign="top" align="center" colspan="2"><sans-serif>LC</sans-serif></th>
<th valign="top" align="center"><sans-serif>RI</sans-serif></th>
<th valign="top" align="center" colspan="2"><sans-serif>LC</sans-serif></th>
<th valign="top" align="center"><sans-serif>RI</sans-serif></th>
<th valign="top" align="center" colspan="2"><sans-serif>LC</sans-serif></th>
</tr>
<tr>
<th valign="top" align="left">Budget</th>
<th valign="top" align="center">-</th>
<th valign="top" align="center">Mobility (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM95"><mml:mn>95.5</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>)</th>
<th valign="top" align="center">Exposure risk (18,800)</th>
<th valign="top" align="center">-</th>
<th valign="top" align="center">Mobility (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM96"><mml:mn>92.3</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>)</th>
<th valign="top" align="center">Exposure risk (16,900)</th>
<th valign="top" align="center">-</th>
<th valign="top" align="center">Mobility (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM97"><mml:mn>69.2</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>)</th>
<th valign="top" align="center">Exposure risk (12,700)</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" colspan="10">Infection reduction outcomes</td>
</tr>
<tr>
<td valign="top" align="left">Peak infections (&#x0025;)</td>
<td valign="top" align="center">25.34 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM98"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>12)</td>
<td valign="top" align="center">36.92 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM99"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>14)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM100"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">34.30 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM101"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>13)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM102"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">35.44 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM103"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>10)</td>
<td valign="top" align="center">49.33 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM104"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>11)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM105"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">52.19 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM106"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>10)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM107"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">61.62 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM108"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>7)</td>
<td valign="top" align="center">69.34 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM109"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>5)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM110"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">64.44 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM111"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>6)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM112"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
</tr>
<tr>
<td valign="top" align="left">Total infections (&#x0025;)</td>
<td valign="top" align="center">6.99 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM113"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>5)</td>
<td valign="top" align="center">10.63 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM114"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>6)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM115"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">8.19 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM116"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>5)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM117"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">14.88 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM118"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>4)</td>
<td valign="top" align="center">13.96 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM119"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>6)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM120"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">15.67 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM121"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>6)</td>
<td valign="top" align="center">33.00 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM122"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>5)</td>
<td valign="top" align="center">33.4 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM123"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>5)</td>
<td valign="top" align="center">26.94 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM124"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>5)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM125"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
</tr>
<tr>
<td valign="top" align="left">Internal transmissions (&#x0025;)</td>
<td valign="top" align="center">17.13 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM126"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>9)</td>
<td valign="top" align="center">22.62 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM127"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>11)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM128"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">21.01 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM129"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>11)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM130"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">27.58 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM131"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>8)</td>
<td valign="top" align="center">35.35 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM132"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>12)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM133"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">39.20 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM134"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>11)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM135"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">54.00 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM136"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>8)</td>
<td valign="top" align="center">70.89 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM137"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>7)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM138"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
<td valign="top" align="center">60.90 (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM139"><mml:mo>&#x00B1;</mml:mo></mml:math></inline-formula>9)<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM140"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup></mml:math></inline-formula></td>
</tr>
<tr>
<td valign="top" align="left" colspan="10">Burdens on campus</td>
</tr>
<tr>
<td valign="top" align="left">Locations affected</td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM141"><mml:mn>58</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM142"><mml:mn>18</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM143"><mml:mn>19</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM144"><mml:mn>58</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM145"><mml:mn>38</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM146"><mml:mn>50</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM147"><mml:mn>58</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM148"><mml:mn>192</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM149"><mml:mn>124</mml:mn></mml:math></inline-formula></td>
</tr>
<tr>
<td valign="top" align="left">Students avoiding (&#x0025;)</td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM150"><mml:mn>0</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM151"><mml:mn>0</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM152"><mml:mn>0</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM153"><mml:mn>9.30</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM154"><mml:mn>0.20</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM155"><mml:mn>0.45</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM156"><mml:mn>27.21</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM157"><mml:mn>12.45</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM158"><mml:mn>6.57</mml:mn></mml:math></inline-formula></td>
</tr>
<tr>
<td valign="top" align="left">Completely isolated on campus (&#x0025;)</td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM159"><mml:mn>5.42</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM160"><mml:mn>8.40</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM161"><mml:mn>8.40</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM162"><mml:mn>5.95</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM163"><mml:mn>5.72</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM164"><mml:mn>5.71</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM165"><mml:mn>7.09</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM166"><mml:mn>5.18</mml:mn></mml:math></inline-formula></td>
<td valign="top" align="center"><inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM167"><mml:mn>5.23</mml:mn></mml:math></inline-formula></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table-fn2"><p>Within each behavioral scenario, we performed the Kruskal-Wallis H-Test (<xref ref-type="bibr" rid="B63">63</xref>) to compare outcomes of <sans-serif>LC</sans-serif> with <sans-serif>RI</sans-serif>. We found that <sans-serif>LC</sans-serif> leads to significantly improved peak infection reduction and internal transmission. In terms of reduction in total infections, the outcomes were comparable in general but varied by specific scenarios. In addition, every policy also exerted some burden on campus, either in terms of locations affected, students avoiding campus or isolation. We observed that <sans-serif>LC</sans-serif> policies focus on fewer locations (except in <italic>S3</italic>). Moreover, these policies affected fewer student&#x2019;s schedules and therefore fewer people avoid campus due to completely remote schedules. Finally, <sans-serif>LC</sans-serif> does not increase the percentage of people completely isolated on campus (<inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM168"><mml:mi>p</mml:mi></mml:math></inline-formula>-value: <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM169"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup><mml:mo>&#x003C;</mml:mo></mml:math></inline-formula>0.01, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM170"><mml:msup><mml:mi></mml:mi><mml:mrow><mml:mo>&#x2217;</mml:mo><mml:mo>&#x2217;</mml:mo></mml:mrow></mml:msup><mml:mo>&#x003C;</mml:mo></mml:math></inline-formula>0.001).</p></fn>
</table-wrap-foot>
</table-wrap>
<p>We present differences between <sans-serif>LC</sans-serif> and <sans-serif>RI</sans-serif> based on three infection reduction outcomes; peak infections (maximum active cases on a given day), internal transmission (exposure from infected individuals on campus), and total infections (cumulative cases at the end of the semester). Additionally, we measured the burden of policy interventions with the number of locations closed&#x2014;requires resources to monitor and maintain super-spreader locations, the percentage of students that avoid campus&#x2014;disruption to learning outcomes (<xref ref-type="bibr" rid="B13">13</xref>,<xref ref-type="bibr" rid="B20">20</xref>), and the percentage of individuals completely isolated&#x2014;worsens mental wellbeing (<xref ref-type="bibr" rid="B64">64</xref>).</p>
</sec>
<sec id="s3b2"><label>3.2.2.</label><title><sans-serif>LC</sans-serif> cause greater reduction in peak infections, while affecting fewer locations</title>
<p>Controlling peak infections relaxes the burden on a university to support positive cases for any given day, and allows resources to be distributed over time. In all behavioral scenarios of our simulation of Fall 2019, we observed that the peak reduction was significantly better in <sans-serif>LC</sans-serif> (<xref ref-type="fig" rid="F3">Figure&#x00A0;3</xref>) than <sans-serif>RI</sans-serif>. While <sans-serif>RI</sans-serif> impacted <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM171"><mml:mn>58</mml:mn></mml:math></inline-formula> different locations (classrooms and lecture halls), in <italic>S1</italic> and <italic>S2</italic>, <sans-serif>LC</sans-serif> achieved better outcomes by closing fewer locations. For example, in <italic>S2</italic>, <sans-serif>RI</sans-serif> achieved a <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM172"><mml:mn>28.9</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> peak reduction, but <sans-serif>LC</sans-serif> showed reductions of <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM173"><mml:mn>49.3</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> (mobility budget) and <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM174"><mml:mn>48.1</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> (exposure risk budget). This was attained by closing <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM175"><mml:mn>38</mml:mn></mml:math></inline-formula> or <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM176"><mml:mn>50</mml:mn></mml:math></inline-formula> locations respectively. Therefore, with such policies, policymakers need to restrict fewer locations to remarkably minimize the pressure of active infections on campus (e.g., diagnoses, treatment, quarantining).</p>
</sec>
<sec id="s3b3"><label>3.2.3.</label><title><sans-serif>LC</sans-serif> lead to comparable reduction in total infections, while keeping more students on campus</title>
<p>Universities want to minimize the number of infected cases while ensuring majority of the population remains active on campus to continue successful operation. In Scenario <italic>S1</italic>, the total number of infections reduced by both <sans-serif>LC</sans-serif> was more than the reduction shown by <sans-serif>RI</sans-serif>. were similar. For other behavioral scenarios the total infection reduction between policies was similar (<xref ref-type="sec" rid="s12">Table S2</xref>). In contrast, the impact the policies had on the student schedules was remarkably different. <sans-serif>RI</sans-serif> forced multiple students to adapt to fully online schedules. In Scenario <italic>S2</italic>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM177"><mml:mn>9</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of students did not visit campus and in <italic>S3</italic>, <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM178"><mml:mn>27</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of students did not visit campus. On the other hand, in <sans-serif>LC</sans-serif>, the number of students expected to avoid campus could be as low as <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM179"><mml:mn>0</mml:mn></mml:math></inline-formula> and never exceeded <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM180"><mml:mn>12</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>. Besides sustaining economic loss to the campus, remote instruction can increase anxiety among students and hinder learning outcomes (<xref ref-type="bibr" rid="B20">20</xref>,<xref ref-type="bibr" rid="B21">21</xref>). Compared to <sans-serif>RI</sans-serif>, <sans-serif>LC</sans-serif> offers policymakers a way to defend against turnover in the student population, without compromising overall control of disease spread (<xref ref-type="table" rid="T2">Table&#x00A0;2</xref>). Limiting the number of students that avoid campus helps preserve on-campus businesses (<xref ref-type="bibr" rid="B18">18</xref>,<xref ref-type="bibr" rid="B19">19</xref>) and minimally disrupts the student wellbeing.</p>
</sec>
<sec id="s3b4"><label>3.2.4.</label><title><sans-serif>LC</sans-serif> cause greater reduction in internal transmission without causing further isolation on campus</title>
<p>Universities are responsible for limiting spread on campus, but they must also ensure that aggressive policies do not worsen mental wellbeing of the community. In terms of internal transmission the reduction is significantly larger with <sans-serif>LC</sans-serif> (<xref ref-type="table" rid="T2">Table&#x00A0;2</xref>). However, when <sans-serif>LC</sans-serif> restricted the infections early in Fall 2019, it left more individuals susceptible to external transmission. College student behavior outside campus on weekends and breaks is known to impact local transmission (<xref ref-type="bibr" rid="B65">65</xref>). When policymakers consider <sans-serif>LC</sans-serif> they should also consider policies on re-entry or required testing based on off-campus activities. In terms of isolating individuals on campus, it&#x2019;s notable that <sans-serif>LC</sans-serif> and <sans-serif>RI</sans-serif> were similar in <italic>S2</italic>. Interestingly, in <italic>S3</italic>, where <sans-serif>LC</sans-serif> closed more than <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM181"><mml:mn>100</mml:mn></mml:math></inline-formula> locations, the percentage of isolated individuals per week was less than that of <sans-serif>RI</sans-serif>. This finding implies that <sans-serif>LC</sans-serif> can keep individuals on campus without forcing them into complete isolation. Here &#x201C;isolation&#x201D; refers to no form of proximate contact with any individual on campus&#x2014;extreme social distancing where individuals are not even collocated in the same suite or hall. While social distancing is a recommended countermeasure for COVID-19 (<xref ref-type="bibr" rid="B8">8</xref>), complete isolation can have adverse effects on psychological wellbeing (<xref ref-type="bibr" rid="B64">64</xref>,<xref ref-type="bibr" rid="B66">66</xref>,<xref ref-type="bibr" rid="B67">67</xref>). <sans-serif>LC</sans-serif> can help alleviate concerns of closure interventions that increase loneliness and limit social connectedness (<xref ref-type="bibr" rid="B66">66</xref>).</p>
</sec>
<sec id="s3b5"><label>3.2.5.</label><title><sans-serif>LC</sans-serif> identifies a wider variety of auxiliary spaces</title>
<p>By using <sc>WiMob</sc> to design <sans-serif>LC</sans-serif> we were able to identify locations for closure at the granularity level of rooms, including unbound spaces such as lobbies and work areas. As policy design budgets changed with every behavioral scenario we found that LC identified different types of locations for closure. First, in <italic>S1</italic>, we found that most locations that <sans-serif>LC</sans-serif> targeted are a subset of the auditoriums&#x2013;like rooms where large classes would take place in Fall 2019. Note, <sans-serif>LC</sans-serif> needs to restrict only a few such spaces to utilize the same budget as <sans-serif>RI</sans-serif>. This is because, under <italic>S1</italic>, <sans-serif>RI</sans-serif> policies only altered visits to lectures, while these spaces are used for other purposes during other times (e.g., club activities and seminars). We also noted that <sans-serif>LC</sans-serif> targeted &#x201C;high traffic&#x201D; locations like conference center lobbies which are typically used as waiting areas or for networking events. Next, in Scenario <italic>S2</italic>, we saw that in addition to spaces mentioned earlier, interestingly <sans-serif>LC</sans-serif> further restricted the use of smaller rooms (occupancy 13&#x2013;35) which would not be affected by <sans-serif>RI</sans-serif> (as only classes of size <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM182"><mml:mo>&#x2265;</mml:mo></mml:math></inline-formula>30 are offered online). <sans-serif>LC</sans-serif> also targeted areas in the recreation center (which includes locker rooms and indoor courts for 4&#x2013;20 people). This insight indicates that our methodology <sc>WiMob</sc> accounts for a diverse set of student activities. Moreover, we also found a selection of spaces that would not be frequented by the undergraduate population, such as lab areas and facility buildings like the police station. Lastly, in Scenario <italic>S3</italic>, <sans-serif>LC</sans-serif> targeted closure of activity in far more spaces than <sans-serif>RI</sans-serif>. However, the better outcomes can be attributed to the fact that <sans-serif>LC</sans-serif> diversified the potential restriction areas. <sans-serif>LC</sans-serif> restricted heavily used small study rooms or breakout rooms (for 1&#x2013;6 people). Furthermore, it restricts use of spaces where multiple small groups of people can organically assemble, such as cafes, dining halls, and reading areas. We also observed that <sans-serif>LC</sans-serif> restricted activity in about 10 Greek Houses but does not target other housing areas&#x2014;demonstrating its ability to restrict social behavior that could amplify disease spread. <xref ref-type="sec" rid="s12">Figure S18D</xref> shows the diversity in locations for various <sans-serif>LC</sans-serif> policies.</p>
</sec>
<sec id="s3b6"><label>3.2.6.</label><title>Sensitivity and robustness analyses</title>
<p>The results above use an <sc>ABM</sc> calibrated on the positivity rate of the first <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM183"><mml:mn>5</mml:mn></mml:math></inline-formula> weeks of Fall 2020. This rate can be influenced by many latent factors (e.g., mask-wearing, hand washing, distancing, and compliance). To study any effect of these variations, we also calibrated on different time windows throughout the semester. We calibrate on weeks 5&#x2013;9 and 10&#x2013;14 in Fall 2020, and validate on the remaining semester. In both cases, compared to <sans-serif>RI</sans-serif>, we found that <sans-serif>LC</sans-serif> still exhibits better reduction in peak infections (up to <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM184"><mml:mn>90</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>) and internal transmission (up to <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM185"><mml:mn>77</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula>). In the original calibration, <sans-serif>LC</sans-serif> maintained the same level of total infections as <sans-serif>RI</sans-serif>, but with the new periods we found total infections were substantially less than <sans-serif>RI</sans-serif> (<xref ref-type="sec" rid="s12">Tables S8 and S9</xref>). Another important variable for positivity is the wider context of the campus e.g. urban/rural, the surrounding county, city, etc. To investigate this, we also calibrated our <sc>ABM</sc> on the positivity rate of different universities in the US in Fall 2020 (along with information from their county to seed external cases). Consider this as a hypothetical where the mobility of the GT community remains the same but disease outcomes resemble a different campus. We calibrated on data from University of Illinois at Urbana-Champaign and University of California, Berkeley. We found no remarkable differences from our findings with GT (<xref ref-type="sec" rid="s12">Tables S10 and S11</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s4" sec-type="discussion"><label>4.</label><title>Discussion</title>
<p>Non-pharmaceutical interventions (NPI) are the first line of defense for universities to respond to contagious diseases like COVID-19 (<xref ref-type="bibr" rid="B68">68</xref>,<xref ref-type="bibr" rid="B69">69</xref>) and are also crucial to control infections and continue operations until recovery. On a campus, a common form of NPI is closure (<xref ref-type="bibr" rid="B70">70</xref>). Universities consider enrollment data (<sc>En</sc>) to design remote instruction (<sans-serif>RI</sans-serif>) for closure to support continued operations safely (<xref ref-type="bibr" rid="B11">11</xref>). However, <sc>En</sc> can misconstrue contact on campus, and <sans-serif>RI</sans-serif> policies can have broad impacts despite their effects on curbing the disease spread. This paper demonstrates that repurposing logs from a managed WiFi network (<sc>WiMob</sc>) can help design effective localized closure policies (<sans-serif>LC</sans-serif>). We show that <sc>WiMob</sc> uncovers rich contact dynamics and provides policymakers multiple dimensions to design policies like <sans-serif>LC</sans-serif>. We simulate COVID-19 with an <sc>ABM</sc> that harnesses <sc>WiMob</sc> to compare <sans-serif>RI</sans-serif> and <sans-serif>LC</sans-serif>. As universities plan for future semesters, our results present evidence that <sans-serif>LC</sans-serif> designed with <sc>WiMob</sc> can lead to improved infection reduction outcomes, while simultaneously relaxing burdens on the campus caused by coarse-grained broad <sans-serif>RI</sans-serif> policies.</p>
<sec id="s4a"><label>4.1.</label><title>Generalizability for other contexts</title>
<p>In practice <sans-serif>LC</sans-serif> policies should be deployed in conjunction with the other tools as well like testing, tracing, and quarantining. <sc>WiMob</sc> can complement disease-specific knowledge to identify closure spaces. For example, small indoor spaces with poor ventilation increase the risk of infection for COVID-19 (<xref ref-type="bibr" rid="B71">71</xref>), while other algorithm-identified locations for closure might not require closure because users of a space are compliant with mask-wearing and testing. Further, as a pandemic progresses and public health guidance develops (<xref ref-type="bibr" rid="B72">72</xref>), with <sc>WiMob</sc>, campuses can regulate the restriction of <sans-serif>LC</sans-serif> policies and anticipate the path to &#x201C;normal&#x201D; operations (<xref ref-type="bibr" rid="B3">3</xref>,<xref ref-type="bibr" rid="B4">4</xref>). Moreover, <sc>WiMob</sc> captures various spillover effects that cannot be captured in methods like <sc>En</sc>. For instance, with <sc>WiMob</sc> we observe that the mobility in Fall 2020 was <inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="IM186"><mml:mn>39</mml:mn><mml:mi mathvariant="normal">&#x0025;</mml:mi></mml:math></inline-formula> of that in Fall 2019 because the on-ground policies lead to certain staff working remotely as well. With additional information, <sc>WiMob</sc> enables policymakers to model such scenarios and design alternatives like <sans-serif>LC</sans-serif> with new budgets. Policymakers can use <sc>WiMob</sc> as a versatile tool to explore dynamic intervention strategies as well. Prior work shows that staggering policy restrictions could have variable impact on campus (<xref ref-type="bibr" rid="B73">73</xref>). Accordingly, <sc>WiMob</sc> could be used to build an adaptive version of <sans-serif>LC</sans-serif> that updates at different points in the semester based on expected mobility changes. Additionally, depending on campus priorities and resource limitations, different campuses can use this same data to model policies differently. The effectiveness of reopening policies is expected to be sensitive to a campus&#x2019; specific context that includes physical infrastructure, overarching guidelines, and human compliance (<xref ref-type="bibr" rid="B5">5</xref>). For certain campuses policies might not need to be constrained by exposure risk as testing might be frequent, ubiquitous, and voluminous. Other campuses could have limits on quarantining capacity. Policymakers might even consider the cost trade-offs by actually forecasting actual financial losses incurred by reduction in mobility (<xref ref-type="bibr" rid="B31">31</xref>), or valuate loss of services based on community needs (<xref ref-type="bibr" rid="B74">74</xref>). We elaborate on these considerations in the <xref ref-type="sec" rid="s12">Supplementary Material, Implications for Policy Design</xref>.</p>
</sec>
<sec id="s4b"><label>4.2.</label><title>Operational considerations</title>
<p>Beyond assessing cost-benefits, universities need to devise practical methods of obtaining, storing, and processing mobility of the community as <sc>WiMob</sc>. University can access logs from the managed network internally as it is passively collected. Moreover, it does not require any new form of surveillance sensing but universities must revise terms of use and stay sensitive to community perspectives. Despite population mobility being valuable for many applications (<xref ref-type="bibr" rid="B75">75</xref>), accumulating localization data can be a major privacy concern (<xref ref-type="bibr" rid="B76">76</xref>). Instead, operational applications need to conceive approaches that only retain insights on locations to shutdown but not individual data. Similarly, any operational use needs to employ differential privacy to limit what stakeholders can learn from the data (<xref ref-type="bibr" rid="B77">77</xref>) (e.g., decision-makers can only get a list of candidate locations to close). In the <xref ref-type="sec" rid="s12">Supplementary Material, Discussion</xref>, we further detail approaches to reconcile privacy, ethics and legal considerations.</p>
</sec>
<sec id="s4c"><label>4.3.</label><title>Limitations and future work</title>
<p>For future investigations of better closure policies, researchers and policymakers need to be cognizant of the limitations of our work. Our analyses capture heterogeneity in individual behavior but does not account for differences in intrinsic vulnerabilities, which are related to severity of risk (<xref ref-type="bibr" rid="B67">67</xref>,<xref ref-type="bibr" rid="B78">78</xref>,<xref ref-type="bibr" rid="B79">79</xref>) and disparity in burden of shutdowns on demographic groups (<xref ref-type="bibr" rid="B30">30</xref>). <sc>WiMob</sc> can be extended with other streams of data to characterize sub-contexts in the population and devise new forms of <sans-serif>LC</sans-serif> to explicitly study the impact of policies on specific vulnerable subgroups in the community. Additionally, our work explores the avoidance based behavioral responses to closure interventions with assumptions in line with prior work (<xref ref-type="bibr" rid="B11">11</xref>,<xref ref-type="bibr" rid="B52">52</xref>). Researchers and policymakers can be interested in substitution behaviors where the population visits new locations when others are closed. <sc>WiMob</sc> has the flexibility to model more nuanced spillover effects. Exploring different ways to remove and reallocate edges in the contact network is interesting future work. Lastly, <sc>WiMob</sc> was built on GT&#x2019;s managed WiFi infrastructure with expansive coverage reflecting a large proportion of the campus population and its physical space. The coverage at other campuses might vary depending on how the access points are setup as well as the populations connectivity preferences. These variations can lead to under-representation of certain behaviors during policy evaluation. Thus, future studies can investigate the efficacy of <sc>WiMob</sc> by systematically simulating different configurations of WiFi coverage. Further discussion in <xref ref-type="sec" rid="s12">Supplementary Material, Limitations and Future Work</xref>.</p>
</sec>
</sec>
</body>
<back>
<sec id="s5" sec-type="data-availability"><title>Data availability statement</title>
<p>The code used for processing the WiFi logs into mobility networks can be requested under requisite terms of use agreements. The code for simulation is publicly available at: <ext-link ext-link-type="uri" xlink:href="https://github.com/AdityaLab/cv-wifi-GT">https://github.com/AdityaLab/cv-wifi-GT</ext-link>. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="s6"><title>Ethics statement</title>
<p>The studies involving human participants were reviewed and approved by IRB, Georgia Institute of Technology (Protocol H20208). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements.</p>
</sec>
<sec id="s7"><title>Author contributions</title>
<p>V.D.S., M.D.C., G.D.A., L.N.S., and B.A.P. designed the research; V.D.S., J.X., L.N.S., and B.A.P. performed the research; V.D.S. and G.D.A. acquired the data; V.D.S., J.X., J.C., S.S., and M.M. analyzed, and interpreted data for the work; V.D.S., J.X., M.D.C., G.D.A., L.N.S., and B.A.P. wrote the paper. All authors contributed to the article and approved the submitted version.</p>
</sec>
<sec id="s8" sec-type="funding-information"><title>Funding</title>
<p>This paper is based on work partially supported by the NSF (Expeditions CCF-1918770, CAREER IIS-2028586, RAPID IIS-2027862, RAPID IIS-2027689, Medium IIS-1955883, Medium IIS-2106961, NRT DGE-1545362, CCF-2115126, PIPP CCF-2200269), CDC MInD program, ORNL, Semiconductor Research Corporation (in collaboration with Intel Labs), and faculty research award from Facebook. Some research personnel were supported by internal seed funding from the Georgia Institute of Technology and Georgia Tech Research Institute. Other computing resources were provided by the Office of Information Technology at Georgia Tech.</p>
</sec>
<ack><title>Acknowledgments</title>
<p>The authors thank Di Wu, Hanna Hamilton, and Dima Nazzal (Georgia Institute of Technology) for their analysis of <sc>En</sc>. The authors are thankful to Mehrab Bin Morshed and Matt Sanders (Georgia Institute of Technology) for mediating and engineering our access to the anonymous WiFi logs for research. A preprint of this article is published at <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1101/2021.03.16.21253662">https://doi.org/10.1101/2021.03.16.21253662</ext-link>.</p>
</ack>
<sec id="s9" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s13" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec id="s12" sec-type="supplementary-material"><title>Supplementary material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fdgth.2023.1060828/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/fdgth.2023.1060828/full&#x0023;supplementary-material</ext-link>.</p>
<supplementary-material id="SD1" content-type="local-data">
<media mimetype="application" mime-subtype="pdf" xlink:href="Datasheet1.pdf"/>
</supplementary-material>
</sec>
<ref-list><title>References</title>
<ref id="B1"><label>1.</label><citation citation-type="other"><collab>WH Organization</collab>, et al. <comment>Critical preparedness, readiness, response actions for COVID-19: interim guidance, 22 March 2020. Tech. rep., World Health Organization (2020)</comment>.</citation></ref>
<ref id="B2"><label>2.</label><citation citation-type="other"><collab>[Dataset] Times TNY</collab>. <comment>Tracking coronavirus cases at U.S. colleges, universities (2021). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.nytimes.com/interactive/2021/us/college-covid-tracker.html">https://www.nytimes.com/interactive/2021/us/college-covid-tracker.html</ext-link></comment>.</citation></ref>
<ref id="B3"><label>3.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Korn</surname><given-names>M</given-names></name></person-group>. <comment>Colleges begin mapping out a more normal fall&#x2013;with caveats (2021). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.wsj.com/articles/colleges-begin-mapping-out-a-more-normal-fallwith-caveats-11615800600?reflink=desktopwebshare_permalink">https://www.wsj.com/articles/colleges-begin-mapping-out-a-more-normal-fallwith-caveats-11615800600?reflink=desktopwebshare&#x02D9;permalink</ext-link></comment>.</citation></ref>
<ref id="B4"><label>4.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Rabin</surname><given-names>RC</given-names></name></person-group>. <comment>C.D.C. officials say most available evidence indicates schools can be safe if precautions are taken on campus, in the community (2021). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.nytimes.com/2021/01/26/world/cdc-schools-reopening.html">https://www.nytimes.com/2021/01/26/world/cdc-schools-reopening.html</ext-link></comment>.</citation></ref>
<ref id="B5"><label>5.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Benneyan</surname><given-names>J</given-names></name><name><surname>Gehrke</surname><given-names>C</given-names></name><name><surname>Ilies</surname><given-names>I</given-names></name><name><surname>Nehls</surname><given-names>N</given-names></name></person-group>. <article-title>Community and campus COVID-19 risk uncertainty under university reopening scenarios: model-based analysis</article-title>. <source>JMIR Public Health surveill</source>. (<year>2021</year>) <volume>7</volume>:<fpage>e24292</fpage>. <pub-id pub-id-type="doi">10.2196/24292</pub-id><pub-id pub-id-type="pmid">33667173</pub-id></citation></ref>
<ref id="B6"><label>6.</label><citation citation-type="other"><collab>[Dataset] for Disease Control C, Prevention</collab>. <comment>Community NPIs: flu prevention in community settings (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/nonpharmaceutical-interventions/community/index.html">https://www.cdc.gov/nonpharmaceutical-interventions/community/index.html</ext-link></comment>.</citation></ref>
<ref id="B7"><label>7.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Nierenberg</surname><given-names>A</given-names></name><name><surname>Pasick</surname><given-names>A</given-names></name></person-group>. <comment>Schools briefing: university outbreaks and parental angst (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.nytimes.com/2020/08/19/us/colleges-closing-covid.html">https://www.nytimes.com/2020/08/19/us/colleges-closing-covid.html</ext-link></comment>.</citation></ref>
<ref id="B8"><label>8.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Andersen</surname><given-names>M</given-names></name></person-group>. <comment>Early evidence on social distancing in response to COVID-19 in the united states. Available at SSRN 3569368 (2020)</comment>.</citation></ref>
<ref id="B9"><label>9.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Badr</surname><given-names>HS</given-names></name><name><surname>Du</surname><given-names>H</given-names></name><name><surname>Marshall</surname><given-names>M</given-names></name><name><surname>Dong</surname><given-names>E</given-names></name><name><surname>Squire</surname><given-names>MM</given-names></name><name><surname>Gardner</surname><given-names>LM</given-names></name></person-group>. <article-title>Association between mobility patterns and COVID-19 transmission in the usa: a mathematical modelling study</article-title>. <source>Lancet Infect Dis</source>. (<year>2020</year>) <volume>20</volume>:<fpage>1247</fpage>&#x2013;<lpage>54</lpage>. <pub-id pub-id-type="doi">10.1016/S1473-3099(20)30553-3</pub-id><pub-id pub-id-type="pmid">32621869</pub-id></citation></ref>
<ref id="B10"><label>10.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Borowiak</surname><given-names>M</given-names></name><name><surname>Ning</surname><given-names>F</given-names></name><name><surname>Pei</surname><given-names>J</given-names></name><name><surname>Zhao</surname><given-names>S</given-names></name><name><surname>Tung</surname><given-names>HR</given-names></name><name><surname>Durrett</surname><given-names>R</given-names></name></person-group>. <article-title>Controlling the spread of COVID-19 on college campuses</article-title>. <source>Math Biosci Eng</source>. (<year>2020</year>) <volume>18</volume>:<fpage>551</fpage>&#x2013;<lpage>63</lpage>. <pub-id pub-id-type="doi">10.3934/mbe.2021030</pub-id><pub-id pub-id-type="pmid">33525107</pub-id></citation></ref>
<ref id="B11"><label>11.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Weeden</surname><given-names>KA</given-names></name><name><surname>Cornwell</surname><given-names>B</given-names></name></person-group>. <article-title>The small-world network of college classes: implications for epidemic spread on a university campus</article-title>. <source>Sociol Sci</source>. (<year>2020</year>) <volume>7</volume>:<fpage>222</fpage>&#x2013;<lpage>41</lpage>. <pub-id pub-id-type="doi">10.15195/v7.a9</pub-id></citation></ref>
<ref id="B12"><label>12.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Smalley</surname><given-names>A</given-names></name></person-group>. <comment>Higher education responses to coronavirus (COVID-19). <italic>National Conference of State Legislatures</italic> (2020). Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncsl.org/research/education/higher-education-responses-to-coronavirus-covid-19.aspx">https://www.ncsl.org/research/education/higher-education-responses-to-coronavirus-covid-19.aspx</ext-link> (Accessed May 15, 2020)</comment>.</citation></ref>
<ref id="B13"><label>13.</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Dorn</surname><given-names>E</given-names></name><name><surname>Hancock</surname><given-names>B</given-names></name><name><surname>Sarakatsannis</surname><given-names>J</given-names></name><name><surname>Viruleg</surname><given-names>E</given-names></name></person-group>. <source>COVID-19 and student learning in the United States: the hurt could last a lifetime</source>. <publisher-name>McKinsey &#x0026; Company</publisher-name> (<year>2020</year>) <volume>1</volume>:<fpage>1</fpage>&#x2013;<lpage>9</lpage>.</citation></ref>
<ref id="B14"><label>14.</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Azevedo</surname><given-names>JP</given-names></name><name><surname>Hasan</surname><given-names>A</given-names></name><name><surname>Goldemberg</surname><given-names>D</given-names></name><name><surname>Iqbal</surname><given-names>SA</given-names></name><name><surname>Geven</surname><given-names>K</given-names></name></person-group>. <source>Simulating the potential impacts of COVID-19 school closures on schooling, learning outcomes: a set of global estimates</source>. <source>World Bank Res Obs</source>. (<year>2021</year>) <volume>36</volume>(<issue>1</issue>):<fpage>1</fpage>&#x2013;<lpage>40</lpage>. <pub-id pub-id-type="doi">10.1093/wbro/lkab003</pub-id></citation></ref>
<ref id="B15"><label>15.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Friedman</surname><given-names>S</given-names></name><name><surname>Hurley</surname><given-names>T</given-names></name><name><surname>Fishman</surname><given-names>T</given-names></name><name><surname>Fritz</surname><given-names>P</given-names></name></person-group>. <comment>COVID-19 impact on higher education (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://www2.deloitte.com/us/en/pages/public-sector/articles/covid-19-impact-on-higher-education.html">https://www2.deloitte.com/us/en/pages/public-sector/articles/covid-19-impact-on-higher-education.html</ext-link></comment>.</citation></ref>
<ref id="B16"><label>16.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>DePietro</surname><given-names>A</given-names></name></person-group>. <comment>Here&#x2019;s a look at the impact of coronavirus (COVID-19) on colleges, universities in the U.S. (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.forbes.com/sites/andrewdepietro/2020/04/30/impact-coronavirus-covid-19-colleges-universities/?sh=26c3f79c61a6">https://www.forbes.com/sites/andrewdepietro/2020/04/30/impact-coronavirus-covid-19-colleges-universities/?sh=26c3f79c61a6</ext-link></comment>.</citation></ref>
<ref id="B17"><label>17.</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Yuen</surname><given-names>V</given-names></name></person-group>. <source>Mounting peril for public higher education during the coronavirus pandemic</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>Center for American Progress</publisher-name> (<year>2020</year>).</citation></ref>
<ref id="B18"><label>18.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Harris</surname><given-names>M</given-names></name><name><surname>Holley</surname><given-names>K</given-names></name></person-group>. <comment>Universities as anchor institutions: economic and social potential for urban development. <italic>Higher education: handbook of theory and research</italic>. Springer (2016). p. 393&#x2013;439</comment>.</citation></ref>
<ref id="B19"><label>19.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Watson</surname><given-names>S</given-names></name><name><surname>Hubler</surname><given-names>S</given-names></name><name><surname>Ivory</surname><given-names>D</given-names></name><name><surname>Gebeloff</surname><given-names>R</given-names></name></person-group>. <comment>A new front in America&#x2019;s pandemic: college towns (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.nytimes.com/2020/09/06/us/colleges-coronavirus-students.html">https://www.nytimes.com/2020/09/06/us/colleges-coronavirus-students.html</ext-link></comment>.</citation></ref>
<ref id="B20"><label>20.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Chirikov</surname><given-names>I</given-names></name><name><surname>Soria</surname><given-names>KM</given-names></name><name><surname>Horgos</surname><given-names>B</given-names></name><name><surname>Jones-White</surname><given-names>D</given-names></name></person-group>. <comment>Undergraduate and graduate students&#x2019; mental health during the COVID-19 pandemic (2020)</comment>.</citation></ref>
<ref id="B21"><label>21.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Woolston</surname><given-names>C</given-names></name></person-group>. <comment>Signs of depression and anxiety soar among US graduate students during pandemic (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.nature.com/articles/d41586-020-02439-6">https://www.nature.com/articles/d41586-020-02439-6</ext-link></comment>.</citation></ref>
<ref id="B22"><label>22.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Rojas</surname><given-names>R</given-names></name><name><surname>Delkic</surname><given-names>M</given-names></name></person-group>. <comment>As states reopen, governors balance existing risks with new ones (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.nytimes.com/2020/05/17/us/coronavirus-states-reopen.html">https://www.nytimes.com/2020/05/17/us/coronavirus-states-reopen.html</ext-link></comment>.</citation></ref>
<ref id="B23"><label>23.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Gurley</surname><given-names>ES</given-names></name></person-group>. <comment>Strategies to support the COVID-19 response in LMICs (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://hopkinsglobalhealth.org/assets/documents/CGH_Webinar_-_Contact_Tracing_(Final_Version).pdf">https://hopkinsglobalhealth.org/assets/documents/CGH&#x02D9;Webinar&#x02D9;-&#x02D9;Contact&#x02D9;Tracing&#x02D9;(Final&#x02D9;Version).pdf</ext-link></comment>.</citation></ref>
<ref id="B24"><label>24.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gibson</surname><given-names>G</given-names></name><name><surname>Weitz</surname><given-names>JS</given-names></name><name><surname>Shannon</surname><given-names>MP</given-names></name><name><surname>Holton</surname><given-names>B</given-names></name><name><surname>Bryksin</surname><given-names>A</given-names></name><name><surname>Liu</surname><given-names>B</given-names></name></person-group>, et al. <article-title>Surveillance-to-diagnostic testing program for asymptomatic SARS-CoV-2 infections on a large, urban campus in fall 2020</article-title>. <source>Epidemiology</source>. (<year>2021</year>) <volume>33</volume>:<fpage>209</fpage>&#x2013;<lpage>16</lpage>. <pub-id pub-id-type="doi">10.1097/EDE.0000000000001448</pub-id></citation></ref>
<ref id="B25"><label>25.</label><citation citation-type="other"><collab>[Dataset] of Public Health GD</collab>. <comment>Georgia department of public health daily status report (2020). Available at <ext-link ext-link-type="uri" xlink:href="https://dph.georgia.gov/covid-19-daily-status-report">https://dph.georgia.gov/covid-19-daily-status-report</ext-link></comment>.</citation></ref>
<ref id="B26"><label>26.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Salath&#x00E9;</surname><given-names>M</given-names></name><name><surname>Kazandjieva</surname><given-names>M</given-names></name><name><surname>Lee</surname><given-names>JW</given-names></name><name><surname>Levis</surname><given-names>P</given-names></name><name><surname>Feldman</surname><given-names>MW</given-names></name><name><surname>Jones</surname><given-names>JH</given-names></name></person-group>. <article-title>A high-resolution human contact network for infectious disease transmission</article-title>. <source>Proc Natl Acad Sci</source>. (<year>2010</year>) <volume>107</volume>:<fpage>22020</fpage>&#x2013;<lpage>5</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.1009094108</pub-id></citation></ref>
<ref id="B27"><label>27.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wesolowski</surname><given-names>A</given-names></name><name><surname>Metcalf</surname><given-names>C</given-names></name><name><surname>Eagle</surname><given-names>N</given-names></name><name><surname>Kombich</surname><given-names>J</given-names></name><name><surname>Grenfell</surname><given-names>BT</given-names></name><name><surname>Bj&#x00F8;rnstad</surname><given-names>ON</given-names></name></person-group>, et al. <article-title>Quantifying seasonal population fluxes driving rubella transmission dynamics using mobile phone data</article-title>. <source>Proc Natl Acad Sci</source>. (<year>2015</year>) <volume>112</volume>:<fpage>11114</fpage>&#x2013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.1423542112</pub-id><pub-id pub-id-type="pmid">26283349</pub-id></citation></ref>
<ref id="B28"><label>28.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Rodr&#x00ED;guez</surname><given-names>A</given-names></name><name><surname>Tabassum</surname><given-names>A</given-names></name><name><surname>Jiaming Cui</surname><given-names>JX</given-names></name><name><surname>Ho</surname><given-names>J</given-names></name><name><surname>Agarwal</surname><given-names>P</given-names></name><name><surname>Adhikari</surname><given-names>B</given-names></name></person-group>, et al. <comment>DeepCOVID: an operational deep learning-driven framework for explainable real-time COVID-19 forecasting. <italic>Proceedings of the AAAI Conference on Artificial Intelligence</italic>. AAAI (2021)</comment>.</citation></ref>
<ref id="B29"><label>29.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zhou</surname><given-names>Y</given-names></name><name><surname>Xu</surname><given-names>R</given-names></name><name><surname>Hu</surname><given-names>D</given-names></name><name><surname>Yue</surname><given-names>Y</given-names></name><name><surname>Li</surname><given-names>Q</given-names></name><name><surname>Xia</surname><given-names>J</given-names></name></person-group>. <article-title>Effects of human mobility restrictions on the spread of COVID-19 in Shenzhen, China: a modelling study using mobile phone data</article-title>. <source>Lancet Digit Health</source>. (<year>2020</year>) <volume>2</volume>:<fpage>e417</fpage>&#x2013;<lpage>24</lpage>. <pub-id pub-id-type="doi">10.1016/S2589-7500(20)30165-5</pub-id><pub-id pub-id-type="pmid">32835199</pub-id></citation></ref>
<ref id="B30"><label>30.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chang</surname><given-names>S</given-names></name><name><surname>Pierson</surname><given-names>E</given-names></name><name><surname>Koh</surname><given-names>PW</given-names></name><name><surname>Gerardin</surname><given-names>J</given-names></name><name><surname>Redbird</surname><given-names>B</given-names></name><name><surname>Grusky</surname><given-names>D</given-names></name></person-group>, et al. <article-title>Mobility network models of COVID-19 explain inequities, inform reopening</article-title>. <source>Nature</source>. (<year>2021</year>) <volume>589</volume>:<fpage>82</fpage>&#x2013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.1038/s41586-020-2923-3</pub-id><pub-id pub-id-type="pmid">33171481</pub-id></citation></ref>
<ref id="B31"><label>31.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Benzell</surname><given-names>SG</given-names></name><name><surname>Collis</surname><given-names>A</given-names></name><name><surname>Nicolaides</surname><given-names>C</given-names></name></person-group>. <article-title>Rationing social contact during the COVID-19 pandemic: transmission risk, social benefits of us locations</article-title>. <source>Proc Natl Acad Sci</source>. (<year>2020</year>) <volume>117</volume>:<fpage>14642</fpage>&#x2013;<lpage>4</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.2008025117</pub-id><pub-id pub-id-type="pmid">32522870</pub-id></citation></ref>
<ref id="B32"><label>32.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Mehrab</surname><given-names>Z</given-names></name><name><surname>Goud Ranga</surname><given-names>A</given-names></name><name><surname>Sarkar</surname><given-names>D</given-names></name><name><surname>Venkatramanan</surname><given-names>S</given-names></name><name><surname>Baek</surname><given-names>YC</given-names></name><name><surname>Swarup</surname><given-names>S</given-names></name></person-group>, et al. <comment>High resolution proximity statistics as early warning for US universities reopening during COVID-19. medRxiv (2020)</comment>.</citation></ref>
<ref id="B33"><label>33.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jia</surname><given-names>JS</given-names></name><name><surname>Lu</surname><given-names>X</given-names></name><name><surname>Yuan</surname><given-names>Y</given-names></name><name><surname>Xu</surname><given-names>G</given-names></name><name><surname>Jia</surname><given-names>J</given-names></name><name><surname>Christakis</surname><given-names>NA</given-names></name></person-group>. <article-title>Population flow drives spatio-temporal distribution of COVID-19 in China</article-title>. <source>Nature</source>. (<year>2020</year>) <volume>582</volume>:<fpage>389</fpage>&#x2013;<lpage>94</lpage>. <pub-id pub-id-type="doi">10.1038/s41586-020-2284-y</pub-id><pub-id pub-id-type="pmid">32349120</pub-id></citation></ref>
<ref id="B34"><label>34.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Buckee</surname><given-names>CO</given-names></name><name><surname>Balsari</surname><given-names>S</given-names></name><name><surname>Chan</surname><given-names>J</given-names></name><name><surname>Crosas</surname><given-names>M</given-names></name><name><surname>Dominici</surname><given-names>F</given-names></name><name><surname>Gasser</surname><given-names>U</given-names></name></person-group>, et al. <article-title>Aggregated mobility data could help fight COVID-19</article-title>. <source>Science (New York, NY)</source>. (<year>2020</year>) <volume>368</volume>:<fpage>145</fpage>&#x2013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1126/science.abb8021</pub-id></citation></ref>
<ref id="B35"><label>35.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Choudhury</surname><given-names>T</given-names></name><name><surname>Pentland</surname><given-names>A</given-names></name></person-group>. <comment>Characterizing social networks using the sociometer. <italic>Proceedings of the North American Association of Computational Social and Organizational Science (NAACSOS)</italic>. NAACSOS. NAACSOS (2004)</comment>.</citation></ref>
<ref id="B36"><label>36.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Eagle</surname><given-names>N</given-names></name><name><surname>Pentland</surname><given-names>AS</given-names></name></person-group>. <article-title>Reality mining: sensing complex social systems</article-title>. <source>Pers Ubiquitous Comput</source>. (<year>2006</year>) <volume>10</volume>:<fpage>255</fpage>&#x2013;<lpage>68</lpage>. <pub-id pub-id-type="doi">10.1007/s00779-005-0046-3</pub-id></citation></ref>
<ref id="B37"><label>37.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sapiezynski</surname><given-names>P</given-names></name><name><surname>Stopczynski</surname><given-names>A</given-names></name><name><surname>Gatej</surname><given-names>R</given-names></name><name><surname>Lehmann</surname><given-names>S</given-names></name></person-group>. <article-title>Tracking human mobility using wifi signals</article-title>. <source>PLoS ONE</source>. (<year>2015</year>) <volume>10</volume>:<fpage>e0130824</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0130824</pub-id><pub-id pub-id-type="pmid">26132115</pub-id></citation></ref>
<ref id="B38"><label>38.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hambridge</surname><given-names>HL</given-names></name><name><surname>Kahn</surname><given-names>R</given-names></name><name><surname>Onnela</surname><given-names>JP</given-names></name></person-group>. <article-title>Examining SARS-CoV-2 interventions in residential colleges using an empirical network</article-title>. <source>Int J Infect Dis</source>. (<year>2021</year>) <volume>113</volume>:<fpage>325</fpage>&#x2013;<lpage>30</lpage>. <pub-id pub-id-type="doi">10.1016/j.ijid.2021.10.008</pub-id><pub-id pub-id-type="pmid">34624516</pub-id></citation></ref>
<ref id="B39"><label>39.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Eldaw</surname><given-names>MHS</given-names></name><name><surname>Levene</surname><given-names>M</given-names></name><name><surname>Roussos</surname><given-names>GPa</given-names></name></person-group>. <comment>making sense of human social presence within a learning environment. <italic>2018 IEEE/ACM 5th International Conference on Big Data Computing Applications and Technologies (BDCAT)</italic>. IEEE (2018). p. 174&#x2013;83</comment>.</citation></ref>
<ref id="B40"><label>40.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ware</surname><given-names>S</given-names></name><name><surname>Yue</surname><given-names>C</given-names></name><name><surname>Morillo</surname><given-names>R</given-names></name><name><surname>Lu</surname><given-names>J</given-names></name><name><surname>Shang</surname><given-names>C</given-names></name><name><surname>Kamath</surname><given-names>J</given-names></name></person-group>, et al. <article-title>Large-scale automatic depression screening using meta-data from WiFi infrastructure</article-title>. <source>Proc ACM Interact Mob Wearable Ubiquitous Technol</source>. (<year>2018</year>) <volume>2</volume>:<fpage>1</fpage>&#x2013;<lpage>27</lpage>. <pub-id pub-id-type="doi">10.1145/3287073</pub-id></citation></ref>
<ref id="B41"><label>41.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Das Swain</surname><given-names>V</given-names></name><name><surname>Kwon</surname><given-names>H</given-names></name><name><surname>Saket</surname><given-names>B</given-names></name><name><surname>Morshed</surname><given-names>MB</given-names></name><name><surname>Tran</surname><given-names>K</given-names></name><name><surname>Patel</surname><given-names>D</given-names></name></person-group>, et al. <comment>Leveraging wifi network logs to infer social interactions: a case study of academic performance and student behavior. arXiv e-prints (2020)</comment>.</citation></ref>
<ref id="B42"><label>42.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Trivedi</surname><given-names>A</given-names></name><name><surname>Zakaria</surname><given-names>C</given-names></name><name><surname>Balan</surname><given-names>R</given-names></name><name><surname>Becker</surname><given-names>A</given-names></name><name><surname>Corey</surname><given-names>G</given-names></name><name><surname>Shenoy</surname><given-names>P</given-names></name></person-group>. <article-title>Wifitrace: network-based contact tracing for infectious diseases using passive WiFi sensing</article-title>. <source>Proc ACM Interact Mob Wearable Ubiquitous Technol</source>. (<year>2021</year>) <volume>5</volume>:<fpage>1</fpage>&#x2013;<lpage>26</lpage>. <pub-id pub-id-type="doi">10.1145/3448084</pub-id></citation></ref>
<ref id="B43"><label>43.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Zakaria</surname><given-names>C</given-names></name><name><surname>Trivedi</surname><given-names>A</given-names></name><name><surname>Cecchet</surname><given-names>E</given-names></name><name><surname>Chee</surname><given-names>M</given-names></name><name><surname>Shenoy</surname><given-names>P</given-names></name><name><surname>Balan</surname><given-names>R</given-names></name></person-group>. <comment>Analyzing the impact of COVID-19 control policies on campus occupancy and mobility via passive wifi sensing [preprint] (2020). <ext-link ext-link-type="uri" xlink:href="http://arxiv.org/2005.12050">http://arxiv.org/2005.12050</ext-link></comment></citation></ref>
<ref id="B44"><label>44.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kissler</surname><given-names>SM</given-names></name><name><surname>Tedijanto</surname><given-names>C</given-names></name><name><surname>Goldstein</surname><given-names>E</given-names></name><name><surname>Grad</surname><given-names>YH</given-names></name><name><surname>Lipsitch</surname><given-names>M</given-names></name></person-group>. <article-title>Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period</article-title>. <source>Science</source>. (<year>2020</year>) <volume>368</volume>:<fpage>860</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1126/science.abb5793</pub-id><pub-id pub-id-type="pmid">32291278</pub-id></citation></ref>
<ref id="B45"><label>45.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Frutos</surname><given-names>R</given-names></name><name><surname>Lopez Roig</surname><given-names>M</given-names></name><name><surname>Serra-Cobo</surname><given-names>J</given-names></name><name><surname>Devaux</surname><given-names>CA</given-names></name></person-group>. <article-title>COVID-19: the conjunction of events leading to the coronavirus pandemic and lessons to learn for future threats</article-title>. <source>Front Med (Lausanne)</source>. (<year>2020</year>) <volume>7</volume>:<fpage>223</fpage>. <pub-id pub-id-type="doi">10.3389/fmed.2020.00223</pub-id><pub-id pub-id-type="pmid">32574324</pub-id></citation></ref>
<ref id="B46"><label>46.</label><citation citation-type="other"><collab>[Dataset] Cisco</collab>. <comment>Wi-Fi location-based services 4.1 design guide white paper (2014). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.cisco.com/c/en/us/td/docs/solutions/Enterprise/Mobility/WiFiLBS-DG/wifich2.html">https://www.cisco.com/c/en/us/td/docs/solutions/Enterprise/Mobility/WiFiLBS-DG/wifich2.html</ext-link></comment>.</citation></ref>
<ref id="B47"><label>47.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Monitor</surname><given-names>AWFL</given-names></name></person-group>. <comment>WiFi location monitor accuracy (2016). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.accuware.com/support/wi-fi-location-monitor-accuracy/">https://www.accuware.com/support/wi-fi-location-monitor-accuracy/</ext-link></comment>.</citation></ref>
<ref id="B48"><label>48.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Page</surname><given-names>L</given-names></name><name><surname>Brin</surname><given-names>S</given-names></name><name><surname>Motwani</surname><given-names>R</given-names></name><name><surname>Winograd</surname><given-names>T</given-names></name></person-group>. <comment>The pagerank citation ranking: Bringing order to the web. Tech. rep., Stanford InfoLab (1999)</comment>.</citation></ref>
<ref id="B49"><label>49.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bonacich</surname><given-names>P</given-names></name></person-group>. <article-title>Some unique properties of eigenvector centrality</article-title>. <source>Soc Networks</source>. (<year>2007</year>) <volume>29</volume>:<fpage>555</fpage>&#x2013;<lpage>64</lpage>. <pub-id pub-id-type="doi">10.1016/j.socnet.2007.04.002</pub-id></citation></ref>
<ref id="B50"><label>50.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Newman</surname><given-names>ME</given-names></name></person-group>. <article-title>Scientific collaboration networks. II. Shortest paths, weighted networks, and centrality</article-title>. <source>Phys Rev E</source>. (<year>2001</year>) <volume>64</volume>:<fpage>016132</fpage>. <pub-id pub-id-type="doi">10.1103/PhysRevE.64.016132</pub-id></citation></ref>
<ref id="B51"><label>51.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Freeman</surname><given-names>LC</given-names></name></person-group>. <article-title>A set of measures of centrality based on betweenness</article-title>. <source>Sociometry</source>. (<year>1977</year>):<fpage>35</fpage>&#x2013;<lpage>41</lpage>. <pub-id pub-id-type="doi">10.2307/3033543</pub-id></citation></ref>
<ref id="B52"><label>52.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bahl</surname><given-names>R</given-names></name><name><surname>Eikmeier</surname><given-names>N</given-names></name><name><surname>Fraser</surname><given-names>A</given-names></name><name><surname>Junge</surname><given-names>M</given-names></name><name><surname>Keesing</surname><given-names>F</given-names></name><name><surname>Nakahata</surname><given-names>K</given-names></name></person-group>, et al. <article-title>Modeling COVID-19 spread in small colleges</article-title>. <source>PLoS ONE</source>. (<year>2021</year>) <volume>16</volume>:<fpage>e0255654</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0255654</pub-id><pub-id pub-id-type="pmid">34407115</pub-id></citation></ref>
<ref id="B53"><label>53.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mangrum</surname><given-names>D</given-names></name><name><surname>Niekamp</surname><given-names>P</given-names></name></person-group>. <article-title>Jue insight: college student travel contributed to local COVID-19 spread</article-title>. <source>J Urban Econ</source>. (<year>2020</year>) 127:103311. <pub-id pub-id-type="doi">10.1016/j.jue.2020.103311</pub-id><pub-id pub-id-type="pmid">33746308</pub-id></citation></ref>
<ref id="B54"><label>54.</label><citation citation-type="other"><collab>[Dataset] of Technology GI</collab>. <comment>Georgia tech launches campus coronavirus testing (2020). Available at <ext-link ext-link-type="uri" xlink:href="https://health.gatech.edu/coronavirus/testing-launched">https://health.gatech.edu/coronavirus/testing-launched</ext-link></comment>.</citation></ref>
<ref id="B55"><label>55.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>McKinnon</surname><given-names>KI</given-names></name></person-group>. <article-title>Convergence of the nelder&#x2013;mead simplex method to a nonstationary point</article-title>. <source>SIAM J Optim</source>. (<year>1998</year>) <volume>9</volume>:<fpage>148</fpage>&#x2013;<lpage>58</lpage>. <pub-id pub-id-type="doi">10.1137/S1052623496303482</pub-id></citation></ref>
<ref id="B56"><label>56.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Keskinocak</surname><given-names>P</given-names></name><name><surname>Oruc</surname><given-names>BE</given-names></name><name><surname>Baxter</surname><given-names>A</given-names></name><name><surname>Asplund</surname><given-names>J</given-names></name><name><surname>Serban</surname><given-names>N</given-names></name></person-group>. <article-title>The impact of social distancing on COVID-19 spread: state of georgia case study</article-title>. <source>PLoS ONE</source>. (<year>2020</year>) <volume>15</volume>:<fpage>e0239798</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0239798</pub-id><pub-id pub-id-type="pmid">33045008</pub-id></citation></ref>
<ref id="B57"><label>57.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Gaythorpe</surname><given-names>K</given-names></name><name><surname>Imai</surname><given-names>N</given-names></name><name><surname>Cuomo-Dannenburg</surname><given-names>G</given-names></name><name><surname>Baguelin</surname><given-names>M</given-names></name><name><surname>Bhatia</surname><given-names>S</given-names></name><name><surname>Boonyasiri</surname><given-names>A</given-names></name></person-group>, et al. <comment>Report 8: symptom progression of COVID-19 (2020)</comment>.</citation></ref>
<ref id="B58"><label>58.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lopman</surname><given-names>B</given-names></name><name><surname>Liu</surname><given-names>CY</given-names></name><name><surname>Le Guillou</surname><given-names>A</given-names></name><name><surname>Handel</surname><given-names>A</given-names></name><name><surname>Lash</surname><given-names>TL</given-names></name><name><surname>Isakov</surname><given-names>AP</given-names></name></person-group>, et al. <article-title>A modeling study to inform screening, testing interventions for the control of SARS-CoV-2 on university campuses</article-title>. <source>Sci Rep</source>. (<year>2021</year>) <volume>11</volume>:<fpage>1</fpage>&#x2013;<lpage>11</lpage>. <pub-id pub-id-type="doi">10.1038/s41598-021-85252-z</pub-id><pub-id pub-id-type="pmid">33414495</pub-id></citation></ref>
<ref id="B59"><label>59.</label><citation citation-type="other"><collab>[Dataset] of Illinois at Urbana-Champaign U</collab>. <comment>On-campus COVID-19 testing (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://covid19.illinois.edu/on-campus-covid-19-testing-data-dashboard/">https://covid19.illinois.edu/on-campus-covid-19-testing-data-dashboard/</ext-link></comment>.</citation></ref>
<ref id="B60"><label>60.</label><citation citation-type="other"><collab>[Dataset] University of California B</collab>. <comment>Coronavirus dashboard testing (2020). Available at: <ext-link ext-link-type="uri" xlink:href="https://coronavirus.berkeley.edu/dashboard/">https://coronavirus.berkeley.edu/dashboard/</ext-link></comment>.</citation></ref>
<ref id="B61"><label>61.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gressman</surname><given-names>PT</given-names></name><name><surname>Peck</surname><given-names>JR</given-names></name></person-group>. <article-title>Simulating COVID-19 in a university environment</article-title>. <source>Math Biosci</source>. (<year>2020</year>) <volume>328</volume>:<fpage>108436</fpage>. <pub-id pub-id-type="doi">10.1016/j.mbs.2020.108436</pub-id><pub-id pub-id-type="pmid">32758501</pub-id></citation></ref>
<ref id="B62"><label>62.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Kondo</surname><given-names>K</given-names></name></person-group>. <comment>Simulating the impacts of interregional mobility restriction on the spatial spread of COVID-19 in Japan. medRxiv (2021) 2020-12</comment>.</citation></ref>
<ref id="B63"><label>63.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kruskal</surname><given-names>WH</given-names></name><name><surname>Wallis</surname><given-names>WA</given-names></name></person-group>. <article-title>Use of ranks in one-criterion variance analysis</article-title>. <source>J Am Stat Assoc</source>. (<year>1952</year>) <volume>47</volume>:<fpage>583</fpage>&#x2013;<lpage>621</lpage>. <pub-id pub-id-type="doi">10.1080/01621459.1952.10483441</pub-id></citation></ref>
<ref id="B64"><label>64.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Saltzman</surname><given-names>LY</given-names></name><name><surname>Hansel</surname><given-names>TC</given-names></name><name><surname>Bordnick</surname><given-names>PS</given-names></name></person-group>. <article-title>Loneliness, isolation,, social support factors in post-COVID-19 mental health</article-title>. <source>Psychol Trauma: Theory Res Pract Policy</source>. (<year>2020</year>) 12:S55.</citation></ref>
<ref id="B65"><label>65.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Dave</surname><given-names>D</given-names></name><name><surname>Friedson</surname><given-names>A</given-names></name><name><surname>Matsuzawa</surname><given-names>K</given-names></name><name><surname>Sabia</surname><given-names>JJ</given-names></name><name><surname>Safford</surname><given-names>S</given-names></name></person-group>. <article-title>Jue insight: WERE urban cowboys enough to control COVID-19? Local shelter-in-place orders, coronavirus case growth</article-title>. <source>J Urban Econ</source>. (<year>2020</year>) 127:<fpage>103294</fpage>. <pub-id pub-id-type="doi">10.1016/j.jue.2020.103294</pub-id><pub-id pub-id-type="pmid">33191960</pub-id></citation></ref>
<ref id="B66"><label>66.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Loades</surname><given-names>ME</given-names></name><name><surname>Chatburn</surname><given-names>E</given-names></name><name><surname>Higson-Sweeney</surname><given-names>N</given-names></name><name><surname>Reynolds</surname><given-names>S</given-names></name><name><surname>Shafran</surname><given-names>R</given-names></name><name><surname>Brigden</surname><given-names>A</given-names></name></person-group>, et al. <article-title>Rapid systematic review: the impact of social isolation, loneliness on the mental health of children and adolescents in the context of COVID-19</article-title>. <source>J Am Acad Child Adolesc Psychiatry</source>. (<year>2020</year>) <volume>59</volume>(<issue>11</issue>):<fpage>1218</fpage>&#x2013;<lpage>39.e3</lpage>. <pub-id pub-id-type="doi">10.1016/j.jaac.2020.05.009</pub-id><pub-id pub-id-type="pmid">32504808</pub-id></citation></ref>
<ref id="B67"><label>67.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pfefferbaum</surname><given-names>B</given-names></name><name><surname>North</surname><given-names>CS</given-names></name></person-group>. <article-title>Mental health and the COVID-19 pandemic</article-title>. <source>N Engl J Med</source>. (<year>2020</year>) <volume>383</volume>:<fpage>510</fpage>&#x2013;<lpage>2</lpage>. <pub-id pub-id-type="doi">10.1056/NEJMp2008017</pub-id><pub-id pub-id-type="pmid">32283003</pub-id></citation></ref>
<ref id="B68"><label>68.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Ferguson</surname><given-names>N</given-names></name><name><surname>Laydon</surname><given-names>D</given-names></name><name><surname>Nedjati Gilani</surname><given-names>G</given-names></name><name><surname>Imai</surname><given-names>N</given-names></name><name><surname>Ainslie</surname><given-names>K</given-names></name><name><surname>Baguelin</surname><given-names>M</given-names></name></person-group>, et al. <comment>Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand (2020)</comment>.</citation></ref>
<ref id="B69"><label>69.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Morse</surname><given-names>SS</given-names></name><name><surname>Garwin</surname><given-names>RL</given-names></name><name><surname>Olsiewski</surname><given-names>PJ</given-names></name></person-group>. <comment>Next flu pandemic: what to do until the vaccine arrives? (2006)</comment>.</citation></ref>
<ref id="B70"><label>70.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Haug</surname><given-names>N</given-names></name><name><surname>Geyrhofer</surname><given-names>L</given-names></name><name><surname>Londei</surname><given-names>A</given-names></name><name><surname>Dervic</surname><given-names>E</given-names></name><name><surname>Desvars-Larrive</surname><given-names>A</given-names></name><name><surname>Loreto</surname><given-names>V</given-names></name></person-group>, et al. <article-title>Ranking the effectiveness of worldwide COVID-19 government interventions</article-title>. <source>Nat Hum Behav</source>. (<year>2020</year>) <volume>4</volume>:<fpage>1303</fpage>&#x2013;<lpage>12</lpage>. <pub-id pub-id-type="doi">10.1038/s41562-020-01009-0</pub-id><pub-id pub-id-type="pmid">33199859</pub-id></citation></ref>
<ref id="B71"><label>71.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Schoen</surname><given-names>LJ</given-names></name></person-group>. <article-title>Guidance for building operations during the COVID-19 pandemic</article-title>. <source>ASHRAE J</source>. (<year>2020</year>) <volume>5</volume>:3.</citation></ref>
<ref id="B72"><label>72.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Saul</surname><given-names>S</given-names></name><name><surname>Hubler</surname><given-names>S</given-names></name></person-group>. <comment>Colleges vowed a safer spring. Then students, and variants, arrived (2021). Available at: <ext-link ext-link-type="uri" xlink:href="https://www.nytimes.com/2021/02/09/us/colleges-covid.html">https://www.nytimes.com/2021/02/09/us/colleges-covid.html</ext-link></comment>.</citation></ref>
<ref id="B73"><label>73.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname><given-names>H</given-names></name><name><surname>Feng</surname><given-names>Z</given-names></name></person-group>. <article-title>Staggered release policies for COVID-19 control: costs and benefits of relaxing restrictions by age and risk</article-title>. <source>Math Biosci</source>. (<year>2020</year>) <volume>326</volume>:<fpage>108405</fpage>. <pub-id pub-id-type="doi">10.1016/j.mbs.2020.108405</pub-id><pub-id pub-id-type="pmid">32565231</pub-id></citation></ref>
<ref id="B74"><label>74.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Suh</surname><given-names>J</given-names></name><name><surname>Horvitz</surname><given-names>E</given-names></name><name><surname>White</surname><given-names>RW</given-names></name><name><surname>Althoff</surname><given-names>T</given-names></name></person-group>. <comment>Population-scale study of human needs during the COVID-19 pandemic: analysis and implications. <italic>Proceedings of the 14th ACM International Conference on Web Search and Data Mining</italic>. Elsevier (2021). p. 4&#x2013;12</comment>.</citation></ref>
<ref id="B75"><label>75.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>Y</given-names></name><name><surname>Li</surname><given-names>B</given-names></name><name><surname>Ramayya</surname><given-names>K</given-names></name></person-group>. <comment>Learning individual behavior using sensor data: the case of gps traces and taxi drivers. <italic>Forthcoming in Information Systems Research</italic>. INFORMS (2020)</comment>.</citation></ref>
<ref id="B76"><label>76.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>JL</given-names></name><name><surname>Loui</surname><given-names>MC</given-names></name></person-group>. <comment>Privacy and ethical issues in location-based tracking systems. <italic>2009 IEEE International Symposium on Technology and Society</italic>. IEEE (2009). p. 1&#x2013;4</comment>.</citation></ref>
<ref id="B77"><label>77.</label><citation citation-type="other"><person-group person-group-type="author"><name><surname>Bagdasaryan</surname><given-names>E</given-names></name><name><surname>Berlstein</surname><given-names>G</given-names></name><name><surname>Waterman</surname><given-names>J</given-names></name><name><surname>Birrell</surname><given-names>E</given-names></name><name><surname>Foster</surname><given-names>N</given-names></name><name><surname>Schneider</surname><given-names>FB</given-names></name></person-group>, et al. <comment>Ancile: enhancing privacy for ubiquitous computing with use-based privacy. <italic>Proceedings of the 18th ACM Workshop on Privacy in the Electronic Society</italic>. ACM (2019). p. 111&#x2013;24</comment>.</citation></ref>
<ref id="B78"><label>78.</label><citation citation-type="other"><collab>[Dataset]</collab> <person-group person-group-type="author"><name><surname>Jordan</surname><given-names>RE</given-names></name><name><surname>Adab</surname><given-names>P</given-names></name><name><surname>Cheng</surname><given-names>K</given-names></name></person-group>. <comment>COVID-19: risk factors for severe disease and death (2020)</comment>.</citation></ref>
<ref id="B79"><label>79.</label><citation citation-type="other"><collab>[Dataset] for Disease Control C, Prevention</collab>. <comment>People at increased risk, other people who need to take extra precautions (2020). Available at <ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/index.html">https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/index.html</ext-link></comment>.</citation></ref></ref-list>
</back>
</article>