<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3-mathml3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.3" xml:lang="EN">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Dement.</journal-id>
<journal-title-group>
<journal-title>Frontiers in Dementia</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Dement.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2813-3919</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/frdem.2026.1736003</article-id>
<article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Review</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Dementia and hearing loss: from risk to mechanisms and management</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Broome</surname>
<given-names>Emma E.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1756924"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="visualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/visualization/">Visualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Funding acquisition" vocab-term-identifier="https://credit.niso.org/contributor-roles/funding-acquisition/">Funding acquisition</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Data curation" vocab-term-identifier="https://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Project administration" vocab-term-identifier="https://credit.niso.org/contributor-roles/project-administration/">Project administration</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Formal analysis" vocab-term-identifier="https://credit.niso.org/contributor-roles/formal-analysis/">Formal analysis</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="methodology" vocab-term-identifier="https://credit.niso.org/contributor-roles/methodology/">Methodology</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Calvert</surname>
<given-names>Sian</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2067648"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Funding acquisition" vocab-term-identifier="https://credit.niso.org/contributor-roles/funding-acquisition/">Funding acquisition</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="methodology" vocab-term-identifier="https://credit.niso.org/contributor-roles/methodology/">Methodology</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Data curation" vocab-term-identifier="https://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Heffernan</surname>
<given-names>Eithne</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Funding acquisition" vocab-term-identifier="https://credit.niso.org/contributor-roles/funding-acquisition/">Funding acquisition</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Henshaw</surname>
<given-names>Helen</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/156902"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Funding acquisition" vocab-term-identifier="https://credit.niso.org/contributor-roles/funding-acquisition/">Funding acquisition</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Khan</surname>
<given-names>Aaliyah</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/3303279"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="visualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/visualization/">Visualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Data curation" vocab-term-identifier="https://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pelekanos</surname>
<given-names>Vassilis</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/3303345"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="visualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/visualization/">Visualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sollini</surname>
<given-names>Joseph</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1826783"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stancel-Lewis</surname>
<given-names>Jack</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/3374356"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dening</surname>
<given-names>Tom</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1835855"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="visualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/visualization/">Visualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Project administration" vocab-term-identifier="https://credit.niso.org/contributor-roles/project-administration/">Project administration</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label><institution>National Institute for Health and Care Research (NIHR), Nottingham Biomedical Research Centre</institution>, <city>Nottingham</city>, <country country="gb">United Kingdom</country></aff>
<aff id="aff2"><label>2</label><institution>Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham</institution>, <city>Nottingham</city>, <country country="gb">United Kingdom</country></aff>
<aff id="aff3"><label>3</label><institution>School of Sport, Exercise &#x0026; Health Sciences, Loughborough University</institution>, <city>Loughborough</city>, <country country="gb">United Kingdom</country></aff>
<aff id="aff4"><label>4</label><institution>School of Medicine, University of Nottingham</institution>, <city>Nottingham</city>, <country country="gb">United Kingdom</country></aff>
<aff id="aff5"><label>5</label><institution>Department of Social Sciences, School of Humanities and Social Sciences, University of Nicosia</institution>, <city>Nicosia</city>, <country country="cy">Cyprus</country></aff>
<aff id="aff6"><label>6</label><institution>Nottingham University Business School, University of Nottingham</institution>, <city>Nottingham</city>, <country country="gb">United Kingdom</country></aff>
<author-notes>
<corresp id="c001"><label>&#x002A;</label>Correspondence: Emma E. Broome, <email xlink:href="mailto:tom.dening@nottingham.ac.uk">emma.broome1@nottingham.ac.uk</email></corresp>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-02-17">
<day>17</day>
<month>02</month>
<year>2026</year>
</pub-date>
<pub-date publication-format="electronic" date-type="collection">
<year>2026</year>
</pub-date>
<volume>5</volume>
<elocation-id>1736003</elocation-id>
<history>
<date date-type="received">
<day>30</day>
<month>10</month>
<year>2025</year>
</date>
<date date-type="rev-recd">
<day>09</day>
<month>01</month>
<year>2026</year>
</date>
<date date-type="accepted">
<day>27</day>
<month>01</month>
<year>2026</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2026 Broome, Calvert, Heffernan, Henshaw, Khan, Pelekanos, Sollini, Stancel-Lewis and Dening.</copyright-statement>
<copyright-year>2026</copyright-year>
<copyright-holder>Broome, Calvert, Heffernan, Henshaw, Khan, Pelekanos, Sollini, Stancel-Lewis and Dening</copyright-holder>
<license>
<ali:license_ref start_date="2026-02-17">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract>
<p>Hearing loss in midlife is an important and potentially modifiable risk factor for the development of dementia. Research examining the association between dementia and hearing loss has expanded rapidly; however, evidence for the mechanisms linking the two conditions is inconclusive, limiting the development of targeted interventions. This review provides a critical overview of current evidence on dementia risk in relation to hearing loss, proposed mechanisms underpinning this association, and emerging evidence on the effectiveness of hearing interventions in modifying trajectories of cognitive decline, dementia risk, and disease progression. Alongside its role as a risk factor, hearing loss commonly co-occurs with dementia, highlighting the need for integrated approaches to care that address the considerable impact of these co-morbid conditions on individuals and communities. Finally, we emphasise the importance of including diverse populations in future research to improve generalisability of findings and help advance equity in dementia prevention and care.</p>
</abstract>
<kwd-group>
<kwd>cognitive impairment</kwd>
<kwd>dementia</kwd>
<kwd>hearing loss</kwd>
<kwd>mechanisms</kwd>
<kwd>presbycusis</kwd>
</kwd-group>
<funding-group>
<funding-statement>The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre Funding Programme (NIHR203310) to (HH, EH, EB and SC); HH and EB from NIHR funding award CDF-2018-11-ST2-016; and HH, EH, EB, and TC from the (UTF53 and UF18). EB acknowledges funding from National Institute for Health and Care Research Three Schools&#x2019; Dementia Programme [102645/TSDRP/UNEB-ICDA-D03]. EH acknowledges support from the NIHR School for Primary Care Research (C019) and NIHR Clinical Research Network East Midlands (USF19). JS was funded by the University of Nottingham, Nottingham Research Fellowship and the Medical Research Foundation (MRF-RGM-HR-23-106). VP is supported by a Medical Research Foundation grant (MRF-RGM-HR-23-101). SC and EB are supported by an NIHR Development and Skills Enhancement Awards (NIHR305707 and NIHR306142).</funding-statement>
</funding-group>
<counts>
<fig-count count="2"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="146"/>
<page-count count="15"/>
<word-count count="12888"/>
</counts>
<custom-meta-group>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Aging and Risk Factors for Dementia</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec1">
<label>1</label>
<title>Introduction</title>
<p>Clinicians working with older people have long been aware that cognitive and hearing impairments often co-occur. There has been an increase in research examining hearing loss and dementia over the last decade, stimulated by the first Lancet Commission report on dementia prevention, intervention and care (<xref ref-type="bibr" rid="ref70">Livingston et al., 2017</xref>), which identified hearing loss from midlife onwards as the largest potentially modifiable population-attributable risk factor for dementia. From this, further research has explored the accuracy of this estimate, the possible underlying mechanisms linking hearing conditions and dementia, and the potential for hearing interventions to reduce the risk of future dementia or to modify the trajectory of cognitive decline for those at risk.</p>
<p>Dementia is a group of symptoms caused by different diseases that affect the brain, impacting 55 million people worldwide (<xref ref-type="bibr" rid="ref137">World Health Organization, 2023</xref>). There is no known cure, but evidence suggests lifestyle modification can help reduce dementia risk or slow its progression (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>; <xref ref-type="bibr" rid="ref98">Patterson, 2018</xref>; <xref ref-type="bibr" rid="ref132">World Health Organisation, 2025</xref>). Hearing loss is defined as a reduced ability to detect sounds compared to someone with normal hearing, typically characterised by pure-tone audiometric hearing thresholds of 20dB hearing level (HL) or worse in each ear (<xref ref-type="bibr" rid="ref138">World Health Organization, 2024</xref>). The primary management strategy for hearing loss is the provision of hearing aids or cochlear implants to provide access to sounds. It affects over 1.5 billion people globally and is a significant contributor to years lived with disability (<xref ref-type="bibr" rid="ref138">World Health Organization, 2024</xref>; <xref ref-type="bibr" rid="ref48">Haile et al., 2024</xref>). The greatest burden is in low- and middle-income countries, where access to hearing care remains limited (<xref ref-type="bibr" rid="ref85">Newall, 2025</xref>). Hearing loss and dementia, both individually and in combination, reduce independence, increase social isolation, impair communication, and increase the burden of care compared to people living without the conditions (<xref ref-type="bibr" rid="ref114">Shukla, 2020</xref>; <xref ref-type="bibr" rid="ref6">Azevedo, 2021</xref>).</p>
<p>Hearing loss often goes undetected and unmanaged. In the context of an ageing population, the potential societal impact of addressing hearing loss as a potentially modifiable risk factor for dementia is substantial (<xref ref-type="bibr" rid="ref120">Stancel-Lewis et al., 2025</xref>). Hearing health is an important consideration for public health, with implications extending beyond individual communication outcomes to healthcare systems, social care demand, and health inequalities (<xref ref-type="bibr" rid="ref120">Stancel-Lewis et al., 2025</xref>; <xref ref-type="bibr" rid="ref97">Parmar et al., 2025</xref>). The intersection of sensory and cognitive decline presents a growing challenge for healthcare systems. This review contributes to the broader field of ageing research by summarising the evidence linking dementia and hearing loss and providing an overview of key issues. We do so by asking: (1) how much dementia risk is attributable to hearing loss? (2) if hearing loss and dementia are linked, what mechanisms could explain this connection? and (3) can hearing interventions modify dementia risk and/or the trajectory of cognitive decline? We then explore areas of current and future research as they relate to the care and management of people with coexisting dementia and hearing loss.</p>
</sec>
<sec id="sec2">
<label>2</label>
<title>Dementia risk and hearing loss</title>
<sec id="sec3">
<label>2.1</label>
<title>The Lancet commission on dementia</title>
<p>The Lancet Standing Commission on Dementia prevention, intervention, and care is an expert panel that provides ongoing, evidence-based recommendations to prevent, manage, and improve care for dementia worldwide. The (<xref ref-type="bibr" rid="ref70">Livingston et al., 2017</xref>, <xref ref-type="bibr" rid="ref69">2020</xref>, <xref ref-type="bibr" rid="ref68">2024</xref>) Lancet Commission reports identify potentially modifiable risk factors for the development of dementia. In these models, potential risk factors are calculated using a weighted population attributable fraction (PAF) with an assumption of causation. It suggests how exposure (or non-exposure) to factors such as hearing loss, contributes to the overall incidence of dementia, based on the contributing factor&#x2019;s relative risk and prevalence in a population (<xref ref-type="bibr" rid="ref77">Mansournia and Altman, 2018</xref>). First, the magnitude of each risk factor is gained from worldwide estimates, then a sample population is used to estimate how these factors cluster within individuals (accepting that individuals often experience multiple risk factors). The PAF is influenced by the sample population data from which it is generated.</p>
<p>The (<xref ref-type="bibr" rid="ref70">Livingston et al., 2017</xref>, <xref ref-type="bibr" rid="ref69">2020</xref>) reports included three observational studies (<xref ref-type="bibr" rid="ref30">Deal, 2017</xref>; <xref ref-type="bibr" rid="ref65">Lin et al., 2011</xref>; <xref ref-type="bibr" rid="ref42">Gallacher et al., 2012</xref>) that assessed the association between hearing loss and dementia in a meta-analysis to calculate the relative PAF posed by hearing loss. In the 2017 report (<xref ref-type="bibr" rid="ref70">Livingston et al., 2017</xref>), three key outcomes from each study were combined using a random effects model, producing a risk ratio (RR) of 1&#x00B7;94 [95% confidence interval (CI) 1&#x00B7;38&#x2013;2&#x00B7;73], suggesting that people with hearing loss were almost twice as likely to develop dementia than those without. When multiple risk factors are combined within a model (as in the Lancet Commission), the PAF is weighted to account for the communality of risk. The PAF of a single risk factor will vary depending on the number of risk factors included in the calculations. Thus, the PAF for hearing loss has decreased from 9&#x00B7;1% in 2017 (<xref ref-type="bibr" rid="ref70">Livingston et al., 2017</xref>) to 8&#x00B7;2% in 2020 (<xref ref-type="bibr" rid="ref69">Livingston et al., 2020</xref>), following the inclusion of three additional risk factors: traumatic brain injury, alcohol consumption and pollution. It is important to note that PAFs for dementia are calculated using data primarily from high-income countries, yet evidence suggests that the burden of modifiable risk factors could be even greater in low-middle income countries (<xref ref-type="bibr" rid="ref95">Paradela et al., 2024</xref>).</p>
<p>The 2024 Commission (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>) included data from six observational studies (four new studies were added; <xref ref-type="bibr" rid="ref11">Brenowitz et al., 2019</xref>; <xref ref-type="bibr" rid="ref78">Marinelli et al., 2022</xref>; <xref ref-type="bibr" rid="ref92">Osler et al., 2019</xref>; <xref ref-type="bibr" rid="ref103">Powell et al., 2022</xref>) and one was removed (<xref ref-type="bibr" rid="ref42">Gallacher et al., 2012</xref>) from the analysis due to updated inclusion/exclusion criteria, with the model producing a hazard ratio of 1&#x00B7;37 (95% CI, 1.38&#x2013;2.73). This model suggests that people with hearing loss had a 37% increased risk of developing dementia compared to those without hearing loss. Results included in the model were unadjusted for hearing intervention use as treat hearing device use as part of the causal pathway between hearing loss and dementia rather than as a confounder. The PAF for hearing loss in this model was 7%, with the inclusion of two further risk factors: vision loss and high LDL cholesterol (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>).</p>
</sec>
<sec id="sec4">
<label>2.2</label>
<title>Citing the evidence from the Lancet commission models</title>
<p>A challenge for the field lies in how the contribution of hearing loss to dementia risk, reported by the Lancet Commission, is cited within the health research literature. Frequently, hearing loss is reported to be the &#x2018;largest&#x2019; or &#x2018;leading&#x2019; risk factor for the development of dementia, whilst ~93% of risk is attributable to age-related changes, genetics, or a combination of other <italic>potentially</italic> modifiable risk factors. When citing the report outcomes, care should be taken to interpret the findings in the context of the available evidence, and inherent model and risk factor assumptions, situated within the wider context of age-related changes and genetic risk.</p>
<p>The PAF suggests that hearing loss contributes to the overall incidence of dementia in terms of the <italic>relative risk</italic> posed together with the <italic>prevalence</italic> of hearing loss within a population (<xref ref-type="bibr" rid="ref77">Mansournia and Altman, 2018</xref>). Hearing loss is highly prevalent, which influences the &#x2018;risk&#x2019;. However, claims that treating hearing loss can &#x2018;reduce dementia cases by 7%&#x2019; probably arise from two assumptions that are not currently supported by the published evidence. First, that hearing loss <italic>can cause</italic> dementia&#x2014;however, evidence to date suggests an association, but does not confirm causation. Second, it implies that hearing loss can be fully corrected through hearing interventions (e.g., hearing aids)&#x2014;which is not the case as interventions help manage hearing loss but do not restore it.</p>
<p>Finally, PAF is context specific, dependent on the data on which it is modelled and can only provide estimates of risk using the best data available at that time. The PAF modelled by the Lancet Commission in 2024 includes clustering of risk estimates from a Norwegian sample, which, despite being the best available evidence, is not wholly representative of other populations. Notwithstanding, risk clustering influences the magnitude of risk factor estimates. Thus, findings should be interpreted within the broader context of model assumptions and existing evidence. More recently, <xref ref-type="bibr" rid="ref54">Ishak et al. (2025)</xref> refined the population-attributable fraction (PAF) for dementia due to hearing loss using pooled international data, suggesting the overall contribution of hearing loss to dementia risk may be smaller but remains among the most significant potentially modifiable risk factors.</p>
<p>Clear and responsible communication of the association between hearing loss and dementia is essential. Messaging that emphasises the broader benefits of addressing hearing loss has been recommended in a position statement by the British Society of Audiology (<xref ref-type="bibr" rid="ref12">British Society of Audiology, 2024</xref>). This includes guidance that hearing devices should not be recommended or marketed based on a dementia risk reduction narrative, but that addressing hearing loss is beneficial for overall wellbeing and quality of life across many areas, including cognition. Overstating the impact of hearing interventions on dementia prevention could promote unrealistic expectations. Directly linking dementia risk to hearing loss could exacerbate the stigma of hearing loss which may inadvertently discourage help-seeking (<xref ref-type="bibr" rid="ref9">Blustein et al., 2023</xref>; <xref ref-type="bibr" rid="ref28">Dawes and Munro, 2024</xref>). Nonetheless, the strength of the association between hearing loss and cognitive decline should not be overlooked. A recent meta-analysis (<italic>n</italic>&#x202F;=&#x202F;1,548,754) found that adult-onset hearing loss significantly increases the risk of cognitive impairment (<xref ref-type="bibr" rid="ref144">Yu, 2024</xref>), highlighting the importance of understanding how these conditions are related.</p>
</sec>
</sec>
<sec id="sec5">
<label>3</label>
<title>Mechanisms for the link between hearing loss and cognitive decline</title>
<p>Several hypotheses have been proposed to account for the observed relationship between hearing loss in midlife and the increased incidence of dementia (see <xref ref-type="fig" rid="fig1">Figure 1</xref>).</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>Summary of proposed hypotheses and mechanistic type. Checkmarks indicate the potential benefit of hearing intervention for dementia risk reduction/delay based on the assumption that each hypothesis occurs in isolation (although they could work in combination). HL, hearing loss; AD, Alzheimer&#x2019;s disease.</p>
</caption>
<graphic xlink:href="frdem-05-1736003-g001.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Table summarizing hypotheses linking hearing loss and cognitive function, including hypothesis, type, summary, and potential intervention benefit. Causal and direct causal hypotheses suggest intervention benefits, while correlational and reverse causal do not.</alt-text>
</graphic>
</fig>
<p>The plausibility and relevance of the proposed mechanisms may depend in part on the timing of hearing loss across the life course. Much of the evidence has focused on hearing loss in mid-life as a risk factor for dementia. Hearing loss in mid-life may have long-term effects on cognitive reserve, brain structure and social engagement which may increase vulnerability to neurodegeneration later in life (<xref ref-type="bibr" rid="ref70">Livingston et al., 2017</xref>; <xref ref-type="bibr" rid="ref69">Livingston et al., 2020</xref>; <xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>; <xref ref-type="bibr" rid="ref65">Lin et al., 2011</xref>). In contrast, hearing loss occurring in later life may in some cases be a consequence of prodromal dementia-related pathology (<xref ref-type="bibr" rid="ref49">Hardy et al., 2016</xref>; <xref ref-type="bibr" rid="ref47">Griffiths et al., 2020</xref>). Distinguishing between these pathways is essential when interpreting mechanistic evidence and evaluating the potential impact of hearing interventions.</p>
<p>Proposed causal mechanisms variously suggest that: (i) hearing loss directly elevates dementia risk; (ii) hearing loss causes knock-on changes that indirectly elevate the risk; or (iii) a combination of the two. Additionally, dementia may cause an elevated risk of hearing loss diagnosis as the early brain changes related to dementia could contribute to hearing loss which is referred to as a &#x201C;reverse causal&#x201D; mechanism. This area is evolving, and within the literature, some interpretations of the proposed mechanisms overlap or are used interchangeably.</p>
<sec id="sec6">
<label>3.1</label>
<title>Hypothesised mechanisms</title>
<sec id="sec7">
<label>3.1.1</label>
<title>Hearing loss alters cognitive function</title>
<sec id="sec8">
<label>3.1.1.1</label>
<title>Cognitive load on perception</title>
<p>Cognitive load relates to brain activity that is consumed, or redirected, in response to a given task, to maintain task execution (<xref ref-type="bibr" rid="ref101">Pichora-Fuller et al., 2016</xref>).</p>
<p>The first explanation is that degraded auditory input (peripheral hearing) demands more cognitive resources for processing, thus reducing central cognitive capacity resulting in cognitive deficits (&#x201C;outside-in&#x201D;) <xref ref-type="bibr" rid="ref53">Huang and Lin, 2024</xref>). As hearing loss compromises the auditory signal, mental efforts are redirected from other tasks towards effortful listening (<xref ref-type="bibr" rid="ref126">Uchida et al., 2019</xref>). Impairment-simulation studies in cognitively healthy young adults support this by showing reduced cognitive test performance (<xref ref-type="bibr" rid="ref41">F&#x00FC;llgrabe, 2020</xref>). Real-time measures, such as pupillometry, a physiological index for cognitive load, provide a more direct assessment of how degraded speech intelligibility affects cognition (<xref ref-type="bibr" rid="ref127">Van Engen and McLaughlin, 2018</xref>). Pupillary response measures increase for individuals with hearing loss, across a broad range of signal-to-noise ratios, compared to a narrower range for those with normal hearing (<xref ref-type="bibr" rid="ref90">Ohlenforst et al., 2017</xref>). Although hearing loss can increase the &#x2018;cognitive load&#x2019;, and hinder task performance, there is limited explanation as to how this can lead to long-term cognitive impairment.</p>
<p>Second, is the concept of reserve, a backup-system compensating for brain insults and damage that would otherwise cause cognitive impairment (<xref ref-type="bibr" rid="ref121">Stern et al., 2019</xref>). This &#x2018;cognitive load&#x2019; hypothesis suggests an &#x201C;inside-out&#x201D; mechanism, where the central cognitive reserve is the limiting factor and so when peripheral demand increases, central deficits become more apparent in other words central limits affect hearing processing (<xref ref-type="bibr" rid="ref134">Wayne and Johnsrude, 2015</xref>).</p>
</sec>
<sec id="sec9">
<label>3.1.1.2</label>
<title>Information degradation</title>
<p>This hypothesis builds upon the &#x201C;inside-out&#x201D; mechanism. Compensating for auditory input degradation may hinder higher-level cognition in favour of auditory processing and speech perception. Given the limited pool of cognitive resources allocated to different mental tasks (<xref ref-type="bibr" rid="ref125">Tun et al., 2009</xref>), increased listening effort compromises higher-level processing, which can manifest as cognitive decline. Interventions to improve auditory processing (e.g., hearing aids), could free resources and improve higher-level cognition (<xref ref-type="bibr" rid="ref134">Wayne and Johnsrude, 2015</xref>; <xref ref-type="bibr" rid="ref100">Pichora-Fuller, 2003</xref>; <xref ref-type="bibr" rid="ref63">Lin and Albert, 2014</xref>; <xref ref-type="bibr" rid="ref94">Panza et al., 2015</xref>; <xref ref-type="bibr" rid="ref108">Ralli et al., 2019</xref>; <xref ref-type="bibr" rid="ref116">Slade et al., 2020</xref>).</p>
</sec>
<sec id="sec10">
<label>3.1.1.3</label>
<title>Sensory deprivation</title>
<p>Prolonged sensory deprivation, due to hearing loss, leads to adverse changes to the structure and function of cognitive brain regions. One possibility is that alterations in auditory system physiology and function, which has anatomical and functional connectivity with the medial temporal lobe (MTL), could cause direct changes in its function and physiology. For example, people with hearing loss have reduced temporal lobe volume (<xref ref-type="bibr" rid="ref63">Lin and Albert, 2014</xref>; <xref ref-type="bibr" rid="ref4">Armstrong et al., 2019</xref>; <xref ref-type="bibr" rid="ref64">Lin et al., 2014</xref>; <xref ref-type="bibr" rid="ref133">Wang et al., 2016</xref>; <xref ref-type="bibr" rid="ref140">Xu et al., 2019</xref>; <xref ref-type="bibr" rid="ref146">Zhang et al., 2022</xref>), altered resting-state functional connectivity (<xref ref-type="bibr" rid="ref71">Loughrey et al., 2018</xref>) and a range of other physiological changes. It might also be that hearing loss causes changes in cognitive brain regions other than the MTL, which alter cognition and increase dementia risk (<xref ref-type="bibr" rid="ref103">Powell et al., 2022</xref>).</p>
<p>This hypothesis generally considers hearing loss to be the primary cause of cognitive decline, but in many interpretations, it also proposes that hearing loss has consequences, such as social isolation or increased sensory load, that may indirectly increase dementia risk.</p>
</sec>
<sec id="sec11">
<label>3.1.1.4</label>
<title>Cascade</title>
<p>The sensory deprivation hypothesis is closely linked, and often used interchangeably with, the &#x2018;cascade hypothesis&#x2019;, which focuses on indirect changes caused by hearing loss. Social isolation and depression are associated with increased dementia risk (<xref ref-type="bibr" rid="ref33">Desai et al., 2020</xref>; <xref ref-type="bibr" rid="ref99">Penninkilampi et al., 2018</xref>). As hearing loss is associated with increased depressive symptoms (<xref ref-type="bibr" rid="ref23">Cosh et al., 2019</xref>) and reduced social engagement (<xref ref-type="bibr" rid="ref114">Shukla, 2020</xref>; <xref ref-type="bibr" rid="ref46">Gopinath et al., 2012</xref>), it could contribute to dementia via these indirect factors (<xref ref-type="bibr" rid="ref114">Shukla, 2020</xref>; <xref ref-type="bibr" rid="ref103">Powell et al., 2022</xref>). Dementia risk is elevated directly via sensory deprivation and via the cascading effect of hearing loss increasing other risk factors.</p>
</sec>
</sec>
<sec id="sec12">
<label>3.1.2</label>
<title>Common cause</title>
<p>This hypothesis suggests that a shared confounder may underlie both hearing loss and dementia.</p>
<sec id="sec13">
<label>3.1.2.1</label>
<title>Genetics</title>
<p>Several genetic variants have been associated with both hearing loss and dementia (<xref ref-type="bibr" rid="ref58">Kurniawan et al., 2012</xref>; <xref ref-type="bibr" rid="ref10">Brenowitz et al., 2020</xref>; <xref ref-type="bibr" rid="ref1">Abidin et al., 2021</xref>). Although studies have failed to find a shared genetic architecture, a pattern of overlapping gene sets, involved in similar molecular pathways, appears to contribute to both conditions. The APOE genotype itself may increase the risk of both Alzheimer&#x2019;s Disease (AD) and hearing loss (<xref ref-type="bibr" rid="ref58">Kurniawan et al., 2012</xref>). A higher Alzheimer&#x2019;s disease genetic risk score (including APOE) was strongly linked to poorer speech-in-noise hearing and self-reported hearing difficulties in the UK Biobank dataset (<xref ref-type="bibr" rid="ref10">Brenowitz et al., 2020</xref>). Finally, Mendelian randomisation studies have reported a possible causal association, with APOE acting as a mediator (<xref ref-type="bibr" rid="ref1">Abidin et al., 2021</xref>). APOE genotype appears to differentially influence risk for dementia and hearing loss. The APOE &#x03B5;4 allele, the strongest genetic risk factor for Alzheimer&#x2019;s disease, has also been associated with poorer hearing performance and increased hearing difficulty, suggesting shared biological pathways such as lipid metabolism, neuroinflammation, or vascular dysfunction (<xref ref-type="bibr" rid="ref10">Brenowitz et al., 2020</xref>; <xref ref-type="bibr" rid="ref1">Abidin et al., 2021</xref>). In contrast, APOE &#x03B5;2 is generally considered protective for Alzheimer&#x2019;s disease, although its relationship with hearing outcomes is less well established (<xref ref-type="bibr" rid="ref38">Ferretti, 2018</xref>).</p>
</sec>
<sec id="sec14">
<label>3.1.2.2</label>
<title>Vascular disease</title>
<p>Cerebral hypoperfusion, a proxy for decreased neuronal function, is linked to early hearing loss (<xref ref-type="bibr" rid="ref102">Ponticorvo et al., 2019</xref>) and AD (<xref ref-type="bibr" rid="ref36">Eisenmenger et al., 2023</xref>). Cerebral small vessel disease, investigated through proxies such as white matter hyperintensities, may precipitate neurodegeneration and has been associated with both hearing loss (<xref ref-type="bibr" rid="ref35">Eckert, 2013</xref>) and cognitive decline (<xref ref-type="bibr" rid="ref118">S&#x00F6;derlund et al., 2003</xref>). However, studies still show an association between hearing loss and dementia, even when controlling for vascular risk factors.</p>
</sec>
<sec id="sec15">
<label>3.1.2.3</label>
<title>Cognitive ageing</title>
<p>Ageing itself is a risk factor for both hearing loss and dementia, with incidence of both rising with age. Ageing of the central nervous system reduces brain integrity through volume loss, cortical thinning and neural connectivity changes. Temporal lobe atrophy appears to accelerate in older age, making this region vulnerable to both AD and age-related hearing loss (<xref ref-type="bibr" rid="ref64">Lin et al., 2014</xref>). Mitochondrial dysfunction, oxidative distress and inflammation are associated with ageing and may also contribute to both hearing and cognitive declines (<xref ref-type="bibr" rid="ref119">Srivastava, 2017</xref>).</p>
</sec>
</sec>
<sec id="sec16">
<label>3.1.3</label>
<title>Cognitive decline alters hearing function</title>
<sec id="sec17">
<label>3.1.3.1</label>
<title>Hearing loss as a harbinger</title>
<p>In this hypothesis, hearing loss is a harbinger of underlying dementia pathology. Neurodegenerative changes associated with AD can affect central auditory structures (central presbycusis), resulting in central auditory processing disorder, which most commonly manifests as speech-in-noise hearing impairment. Supporting evidence includes (i) post-mortem Alzheimer&#x2019;s neuropathological evidence found in structures of the central auditory system (<xref ref-type="bibr" rid="ref7">Baloyannis et al., 2009</xref>; <xref ref-type="bibr" rid="ref37">Esiri et al., 1986</xref>; <xref ref-type="bibr" rid="ref61">Lewis et al., 1987</xref>; <xref ref-type="bibr" rid="ref115">Sinha et al., 1993</xref>), (ii) genetic studies showing a possible reverse causal relationship between AD and hearing loss (<xref ref-type="bibr" rid="ref45">Golob et al., 2009</xref>) and (iii) behavioural studies where central auditory dysfunction was linked to cognitive decline (<xref ref-type="bibr" rid="ref43">Gates, 2008</xref>; <xref ref-type="bibr" rid="ref79">Mohammed et al., 2022</xref>).</p>
</sec>
</sec>
<sec id="sec18">
<label>3.1.4</label>
<title>Overdiagnosis</title>
<p>The presence of one condition could create overdiagnosis of the other, given that (<xref ref-type="bibr" rid="ref13">Broome et al., 2023</xref>).</p>
<sec id="sec19">
<label>3.1.4.1</label>
<title>Dementia overdiagnosis</title>
<p>Cognitive screening tools may overlook the impact of hearing impairments on test performance. For example, the Montreal Cognitive Assessment Tool is orally administered, potentially resulting in false positive dementia diagnoses (<xref ref-type="bibr" rid="ref106">Pye et al., 2017</xref>; <xref ref-type="bibr" rid="ref34">Dupuis, 2015</xref>). Individuals with hearing loss may present with similar symptoms as those with dementia (e.g., functional decline, social withdrawal), because of hearing loss rather than cognitive decline (<xref ref-type="bibr" rid="ref13">Broome et al., 2023</xref>).</p>
</sec>
<sec id="sec20">
<label>3.1.4.2</label>
<title>Hearing loss overdiagnosis</title>
<p>Dementia-based pathology could lead to speech comprehension problems, resulting in overdiagnosis of hearing loss. Increased problems with central auditory function could prompt individuals to seek referral to hearing healthcare services and receive a hearing loss diagnosis. This differs subtly from hearing loss as a harbinger, in that increased hearing loss diagnosis does not reflect an actual increase in the probability of hearing loss, but rather an increase in the probability of a person living with dementia having their hearing loss diagnosed relative to the general population (<xref ref-type="bibr" rid="ref103">Powell et al., 2022</xref>).</p>
</sec>
</sec>
<sec id="sec21">
<label>3.1.5</label>
<title>Physiological mechanisms</title>
<p>Neuroanatomical evidence from animal studies suggests multiple pathways link the auditory system with the hippocampal system and the MTL (<xref ref-type="bibr" rid="ref20">Cenquizca and Swanson, 2007</xref>; <xref ref-type="bibr" rid="ref21">Cheng et al., 2011</xref>; <xref ref-type="bibr" rid="ref139">Xiao et al., 2018</xref>; <xref ref-type="bibr" rid="ref8">Billig et al., 2022</xref>). Impaired auditory input may lead to physiological changes in structures related to higher-level cognitive functions.</p>
<p><xref ref-type="bibr" rid="ref47">Griffiths et al. (2020)</xref> proposed that degraded auditory input may lead to either increased or decreased activity associated with auditory cognitive processes in the MTL. These hypotheses are supported by the direct links between increased neuronal activity and AD pathology, and by animal models indicating that there are interactions between AD pathology and oscillatory activity in the MTL.</p>
<p>According to the &#x2018;two-hit model&#x2019;, hearing loss may constitute a &#x2018;second hit&#x2019; on the brain, increasing dementia risk by adding to brain pathology, resulting from amyloid-beta accumulation, neurofibrillary tangles and microvascular disease (<xref ref-type="bibr" rid="ref126">Uchida et al., 2019</xref>; <xref ref-type="bibr" rid="ref64">Lin et al., 2014</xref>).</p>
<p>Hearing loss in older adults has been associated with higher CSF levels of tau or ptau181 (<xref ref-type="bibr" rid="ref5">Azeem et al., 2023</xref>; <xref ref-type="bibr" rid="ref59">Lasica et al., 2025</xref>), while variation in the metabotropic glutamate receptor gene may be a risk for hearing loss, possibly by modifying susceptibility to glutamate excitotoxicity. The glutamatergic pathway is also involved in AD (<xref ref-type="bibr" rid="ref94">Panza et al., 2015</xref>). Increased brain atrophy and higher tau proteins in adult-onset hearing loss may lead to reduced cognitive reserve and elevated dementia risk.</p>
<p>Hearing loss may cause disruption and/or reduction in the integrity of white matter tracts (<xref ref-type="bibr" rid="ref94">Panza et al., 2015</xref>; <xref ref-type="bibr" rid="ref40">Ford et al., 2018</xref>).</p>
<p>Furthermore, there is evidence for alterations in neurotransmission including reduced GABA levels found in humans and animals with hearing loss (<xref ref-type="bibr" rid="ref116">Slade et al., 2020</xref>). Noise-induced hearing loss in animal models is associated with increased density of the vesicular glutamate transporter and decreased density of the vesicular GABA transporter, along with hippocampal changes including tau hyperphosphorylation, an increase of mitochondrial area in hippocampal neurons, widened synaptic cleft, thinned postsynaptic density, and reduced mean optical density of Nissl bodies (<xref ref-type="bibr" rid="ref146">Zhang et al., 2022</xref>; <xref ref-type="bibr" rid="ref5">Azeem et al., 2023</xref>).</p>
<p>Hearing loss, induced by ear occlusion techniques, alters neuroinflammatory markers, which may lead to morphological microglial alterations, potentially causing impaired hippocampal neurogenesis (<xref ref-type="bibr" rid="ref5">Azeem et al., 2023</xref>). Whereas hearing loss induced by cochlear ablation has been shown to decrease hippocampal synaptic proteins, resulting in hippocampal synapses becoming more vulnerable to damage (<xref ref-type="bibr" rid="ref108">Ralli et al., 2019</xref>; <xref ref-type="bibr" rid="ref5">Azeem et al., 2023</xref>).</p>
<p>Studies using animal models of AD suggest that inducing hearing loss in AD-model mice worsens neuropathological AD markers and leads to early AD-related disruptions at multiple levels, including: brainstem-level auditory dysfunction, synaptic and morphological alternations in the auditory cortex, elevated tau phosphorylation, neuroinflammation, oxidative imbalance, reduced cerebral glucose metabolism, and accelerated grey-matter reductions in multiple brain regions (<xref ref-type="bibr" rid="ref57">Kim, 2020</xref>; <xref ref-type="bibr" rid="ref67">Liu et al., 2020</xref>; <xref ref-type="bibr" rid="ref81">Na, 2023</xref>; <xref ref-type="bibr" rid="ref93">Paciello, 2021</xref>).</p>
<p>Furthermore, other animal models suggest that the association between hearing loss and dementia may be explained by cellular effects (e.g., oxidative stress, altered gene expression) or changes in neural circuit function (<xref ref-type="bibr" rid="ref55">Johnson, 2021</xref>), or AD-related cochlear DNA damage (<xref ref-type="bibr" rid="ref96">Park et al., 2024</xref>).</p>
<p>Finally, sex differences are notable in both dementia and hearing loss (<xref ref-type="bibr" rid="ref38">Ferretti, 2018</xref>; <xref ref-type="bibr" rid="ref51">Homans et al., 2017</xref>). Women have a higher overall rate of dementia diagnoses, largely driven by Alzheimer&#x2019;s disease prevalence, whereas vascular dementia is more common in men, particularly at younger ages (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>). For hearing loss, while occupational hearing loss is more prevalent in men, age-related hearing loss is more prevalent and severe in adulthood among women (<xref ref-type="bibr" rid="ref48">Haile et al., 2024</xref>). These sex-dependent patterns suggest that neurodegenerative pathways, and any modifiers of risk such as hearing loss, could interact differently in women and men. However, this is yet to be examined in detail.</p>
<p>Given that both dementia and hearing loss are multifaceted, it is likely that the mechanisms linking them are similarly complex, encompassing a range of interrelated biological, psychological, demographic, and social pathways. Thus, the potential benefits offered by hearing interventions would vary according to the proposed mechanism. Recent work by <xref ref-type="bibr" rid="ref60">Levett et al. (2025)</xref> proposed a &#x2018;cause&#x2013;catalyst&#x2013;consequence&#x2019; model, integrating neuroanatomical, psychosocial and neuropathological evidence to explain bidirectional links between hearing loss and dementia.</p>
<p>In summary, it remains unclear which mechanisms link hearing loss and dementia, whether they act in isolation or in combination, and how this influences the potential impact of interventions.</p>
</sec>
</sec>
</sec>
<sec id="sec22">
<label>4</label>
<title>Can hearing interventions prevent dementia?</title>
<p>Although hearing interventions could benefit population health if they reduced or altered the trajectory of cognitive decline and dementia, this has yet to be robustly demonstrated. <xref ref-type="table" rid="tab1">Table 1</xref> summarises the literature on hearing interventions related to dementia and/or cognitive decline, organised by 1. controlled trials and 2. cohort and observational studies. All trials investigated hearing aids (HAs); however, marked methodological differences including recruitment, randomisation and the nature of the conditions, make the synthesis of results inappropriate.</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Review of primary evidence on hearing interventions and dementia prevention.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Study</th>
<th align="center" valign="top">N</th>
<th align="left" valign="top">Study design follow-up (years)</th>
<th align="left" valign="top">Intervention: hearing aids (HA), cochlear implants (CI)</th>
<th align="left" valign="top">Main findings</th>
<th align="left" valign="top">Supports hearing intervention modifying the trajectory of cognitive decline or risk of dementia?</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" colspan="6">Controlled trials</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref128">van Hooren (2005)</xref> Netherlands</td>
<td align="center" valign="top">102</td>
<td align="left" valign="top">Non-randomised controlled trial.<break/>1&#x202F;yr.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HA improved hearing acuity in those who received the intervention relative to those who did not, but no significant improvements in cognitive performance over 12&#x202F;months.</td>
<td align="left" valign="top">No</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref86">Nguyen et al. (2017)</xref><break/>France</td>
<td align="center" valign="top">51</td>
<td align="left" valign="top">Multicentre double-blind placebo crossover.<break/>1&#x202F;yr.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">For individuals with AD, HA did not slow cognitive decline.</td>
<td align="left" valign="top">No</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref56">Karawani et al. (2018)</xref><break/>USA</td>
<td align="center" valign="top">32</td>
<td align="left" valign="top">Parallel randomised controlled trial<break/>0&#x00B7;5&#x202F;yrs</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HA led to improved working memory and enhanced cortical processing for speech stimuli. Improved working memory was correlated with increased cortical amplitudes.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref89">Nkyekyer et al. (2019)</xref><break/>Australia</td>
<td align="center" valign="top">40</td>
<td align="left" valign="top">Randomised cross-over pilot.<break/>0&#x00B7;5&#x202F;yrs.</td>
<td align="left" valign="top">HA&#x202F;+&#x202F;auditory training</td>
<td align="left" valign="top">No improvement in cognition despite the use of HA and auditory training.</td>
<td align="left" valign="top">No</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref62">Lin (2023)</xref><break/>USA</td>
<td align="center" valign="top">977</td>
<td align="left" valign="top">Multicentre, parallel group, unmasked, randomised controlled trial.<break/>3&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HAs were not associated with a reduced hazard of cognitive impairment. HAs reduced the rate of cognitive decline, for those with more risk factors for dementia at baseline.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref145">Yu (2025)</xref><break/>UK</td>
<td align="center" valign="top">58</td>
<td align="left" valign="top">Pilot randomised controlled trial</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Observed 1.2 point difference in cognitive performance between the intervention and control groups at 6&#x202F;months. However not statistically significant.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="6">Cohort and observational studies</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref31">Deal et al. (2015)</xref><break/>USA</td>
<td align="center" valign="top">253</td>
<td align="left" valign="top">Cross-sectional and longitudinal pilot<break/>20&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Participants who did not wear HA had the greatest cognitive decline. Slightly greater cognitive decline for participants who used HAs than normal hearing controls.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref27">Dawes et al. (2015)</xref><break/>USA</td>
<td align="center" valign="top">666</td>
<td align="left" valign="top">Longitudinal cohort</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">No significant differences between HA users and non-users in cognitive, social engagement, or mental health outcomes at any time point.</td>
<td align="left" valign="top">No</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref2">Amieva et al. (2015)</xref><break/>France</td>
<td align="center" valign="top">3,670</td>
<td align="left" valign="top">Prospective observational<break/>25&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Slower cognitive decline for those with HL who used HAs than those who did not. For those who used HAs, cognitive decline not significantly different from controls.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref107">Qian et al. (2016)</xref><break/>USA</td>
<td align="center" valign="top">100</td>
<td align="left" valign="top">Cross-sectional observational<break/>N/A</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HA users who had worse hearing performed significantly better on the MMSE than non-HA users. However, HA users did not perform significantly better in tests of executive function.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref80">Mosnier et al. (2018)</xref><break/>France</td>
<td align="center" valign="top">70</td>
<td align="left" valign="top">Longitudinal cohort<break/>5&#x00B7;5&#x2013;8&#x00B7;5&#x202F;yrs</td>
<td align="left" valign="top">CI</td>
<td align="left" valign="top">Low rate of progression to dementia, and cognitive function improved in some individuals with MCI at baseline, indicating possible positive effect.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref73">Maharani et al. (2018)</xref><break/>UK</td>
<td align="center" valign="top">2040</td>
<td align="left" valign="top">Longitudinal cohort<break/>18&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Slower decline in episodic memory performance after, compared to before, HA use.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref3">Amieva et al. (2018)</xref><break/>France</td>
<td align="center" valign="top">3,777</td>
<td align="left" valign="top">Prospective observational<break/>25&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Increased disability and dementia risk in participants with HL but diminished in those participants using HA.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref130">V&#x00F6;lter et al. (2018)</xref><break/>Germany</td>
<td align="center" valign="top">60</td>
<td align="left" valign="top">Longitudinal prospective<break/>1&#x202F;yr.</td>
<td align="left" valign="top">CI</td>
<td align="left" valign="top">CI were associated with improved cognitive performance and quality of life in adults aged 50&#x202F;+&#x202F;years. Those with worse baseline neurocognitive performance had better outcomes.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref74">Mahmoudi et al. (2019)</xref><break/>USA</td>
<td align="center" valign="top">114,862</td>
<td align="left" valign="top">Retrospective cohort<break/>3&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HA use in adults with HL was associated with a delay or prevention of AD or dementia, anxiety or depression and injurious falls.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref113">Sarant et al. (2020)</xref><break/>Australia</td>
<td align="center" valign="top">99</td>
<td align="left" valign="top">Longitudinal observational<break/>1&#x00B7;5&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">No improvements in cognitive test battery scores relative to 18&#x202F;months of HA use. Significant improvements in executive function.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref44">Glick and Sharma (2020)</xref><break/>USA</td>
<td align="center" valign="top">41</td>
<td align="left" valign="top">Prospective observational<break/>0&#x00B7;5&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HA use was associated with a reversal in cross-modal reorganisation for individuals with ARHL. Cortical changes coincided with improvements in auditory perception and cognitive domains.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref122">Tai et al. (2021)</xref><break/>Taiwan</td>
<td align="center" valign="top">1,418</td>
<td align="left" valign="top">Longitudinal cohort<break/>mean 8&#x00B7;9&#x202F;yrs</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">In a subgroup analysis within the hearing-impaired half of the sample, HA use was associated with lower incidence of cognitive impairment when compared to HA non-users, but the adjusted hazard ratio (0&#x00B7;82) was non-significant.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref25">Cuoco et al. (2021)</xref><break/>Italy</td>
<td align="center" valign="top">96</td>
<td align="left" valign="top">Prospective observational<break/>0&#x00B7;5&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Some aspects of cognition improved for those with mild HL, relative to HA use. For individuals with more severe HL, various aspects of cognition tended to worsen.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref16">Bucholc et al. (2021)</xref><break/>USA</td>
<td align="center" valign="top">2,114</td>
<td align="left" valign="top">Longitudinal retrospective.<break/>Follow-up: Time to incident dementia, from MCI.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HA use was associated with a reduced risk of conversion from MCI to all-cause dementia. Accelerated cognitive decline for individuals who did not use HA.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref84">Naylor et al. (2022)</xref><break/>UK</td>
<td align="center" valign="top">380,794</td>
<td align="left" valign="top">Retrospective observational<break/>3&#x00B7;5&#x2013;5&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">For cognitively healthy patients at baseline, who were persistent HA users during follow-up, there was 27% reduced odds of developing dementia, relative to those who were not persistent HA users. Those with dementia at baseline were 54% less likely to be persistent users of HA.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref15">Bucholc (2022)</xref><break/>USA</td>
<td align="center" valign="top">4,358</td>
<td align="left" valign="top">Observational cohort<break/>4&#x202F;yrs. (mean follow-up)</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Reduced MCI likelihood for HA users than individuals with HL who did not use HA. No difference in MCI risk between individuals with HL who used HA and normal hearing individuals.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref52">Huang et al. (2023)</xref>
</td>
<td align="center" valign="top">2,413</td>
<td align="left" valign="top">Prospective observational</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Moderate to severe HL was associated with a higher prevalence of dementia compared to those with normal hearing, and HA use was associated with lower dementia prevalence.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref112">Sarant (2023)</xref><break/>Australia</td>
<td align="center" valign="top">262</td>
<td align="left" valign="top">Prospective observational cohort</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Better cognitive performance at three-year follow-up for those who used HAs than the comparative group.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref91">Okano et al. (2024)</xref>
</td>
<td align="center" valign="top">36</td>
<td align="left" valign="top">Case-controlled observational</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">HA use was associated with stable MMSE-J scores over 12&#x202F;months compared to matched controls.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref18">Cantuaria (2024)</xref><break/>Denmark</td>
<td align="center" valign="top">573,088</td>
<td align="left" valign="top">Population-based cohort<break/>14&#x202F;yrs.</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">Lower dementia risk for individuals with HL who used HAs than individuals who did not use HA.</td>
<td align="left" valign="top">Yes</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref88">Nishiyama et al. (2025)</xref>
</td>
<td align="center" valign="top">117</td>
<td align="left" valign="top">Cross-sectional prospective cohort</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">In a group of individuals who have never used HAs, HL is related to poorer cognitive scores. However, the negative relationship HL and cognitive function was mitigated by the long-term use of HAs.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref131">Voss (2025)</xref><break/>Canada</td>
<td align="center" valign="top">14</td>
<td align="left" valign="top">Prospective observational</td>
<td align="left" valign="top">HA</td>
<td align="left" valign="top">After 12&#x202F;weeks wearing HAs participants improved on all cognitive test outcomes (visual working memory, executive function and processing speed) except verbal fluency.</td>
<td align="left" valign="top">Unclear</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref129">Vandenbroeke et al. (2025)</xref><break/>Belgium</td>
<td align="center" valign="top">25</td>
<td align="left" valign="top">Prospective longitudinal</td>
<td align="left" valign="top">CI</td>
<td align="left" valign="top">Significant improvements in cognition were observed 1&#x202F;year after CI, but gains were no longer observed after 4&#x202F;years.</td>
<td align="left" valign="top">Unclear</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>The six trials were small (<italic>N</italic>&#x202F;=&#x202F;102 or less), with one exception (<xref ref-type="bibr" rid="ref62">Lin, 2023</xref>) (<italic>N</italic>&#x202F;=&#x202F;977), and in some cases, these may be underpowered to detect intervention effects. The results of three trials were negative, reporting no difference due to HAs, with the other three equivocal.</p>
<p>The 23 observational and cohort studies showed large methodological differences, studies of both HAs and Cochlear Implants (CIs), with variable sample sizes (<italic>N</italic>&#x202F;=&#x202F;14 to &#x003E;500,000) and follow-up (0.5&#x2013;25&#x202F;years), different sampling methods and outcome measures (e.g., risk of developing dementia, performance on various cognitive measures). Eleven studies reported positive findings, for example, that HA users had lower dementia risk than non-users (<xref ref-type="bibr" rid="ref18">Cantuaria, 2024</xref>). One reported negative findings (no differences at all; <xref ref-type="bibr" rid="ref27">Dawes et al., 2015</xref>); and the results of the other 11 studies were unclear (including all three CI studies).</p>
<p>There are several systematic reviews relevant to this topic. As studies in earlier reviews were incorporated into more recent reviews, only the four most recent reviews are considered here. Two reviews (<xref ref-type="bibr" rid="ref19">Carasek et al., 2022</xref>; <xref ref-type="bibr" rid="ref143">Yeo et al., 2023</xref>) examined the role of cochlear implants (CIs)/HAs in modifying cognitive decline and reached positive conclusions; these included mainly observational rather than trial data, with the limitations mentioned above. A systematic review and meta-analysis reported no statistically significant benefit of HAs on cognition (<xref ref-type="bibr" rid="ref124">Thosar et al., 2025</xref>). <xref ref-type="bibr" rid="ref142">Yang et al. (2022)</xref> reported no definitive conclusion regarding whether HAs improve cognitive function in individuals without dementia. <xref ref-type="bibr" rid="ref72">Machado et al. (2024)</xref> reported improvement in quality of life, but not in cognition in individuals provided with HAs.</p>
<p>Given the limited number of randomised controlled trials in this area, there is scope for further high-quality research. However, it is challenging to achieve double-blinding in such trials, and a suitable control group needs careful consideration. It requires a sizeable group of people with hearing loss, who are willing to be potentially randomised into a control group without a hearing intervention and remain as participants over an adequate period of follow-up. As this potentially denies them access to a management option beneficial to their hearing, it poses an ethical dilemma. Future trials could consider innovative study designs; for example, a stepped-wedge design could help mitigate ethical concerns by ensuring that all participants eventually receive the hearing intervention.</p>
</sec>
<sec id="sec23">
<label>5</label>
<title>Care and management</title>
<p>Alongside its role as a risk factor, hearing loss commonly co-occurs with dementia. While the potential for cognitive benefit remains uncertain, the value of hearing interventions lies in improving quality of life, enhancing social engagement, and supporting healthy ageing (<xref ref-type="bibr" rid="ref123">Tang et al., 2025</xref>). HAs remain the standard management option for hearing loss (<xref ref-type="bibr" rid="ref82">National Institute for Health and Care Excellence, 2018a</xref>), including for people already living with dementia (<xref ref-type="bibr" rid="ref109">Ray et al., 2019</xref>). The benefits of addressing hearing loss for people living with dementia could include improvements in communication, behavioural and neuropsychiatric dementia symptoms (<xref ref-type="bibr" rid="ref76">Mamo et al., 2017</xref>; <xref ref-type="bibr" rid="ref75">Mamo, 2018</xref>; <xref ref-type="bibr" rid="ref29">Dawes et al., 2019</xref>), and quality of life (<xref ref-type="bibr" rid="ref72">Machado et al., 2024</xref>). However, people with dementia are less likely to use HAs consistently over time compared to those with intact cognition (<xref ref-type="bibr" rid="ref84">Naylor et al., 2022</xref>). Inconsistent or discontinued HA use may contribute to an increased rate of cognitive decline, which in turn reduces capacity to maintain HA use, creating a cycle in which untreated hearing loss and cognitive impairment reinforce one another (<xref ref-type="bibr" rid="ref84">Naylor et al., 2022</xref>).</p>
<p>Effective hearing interventions are not simply a matter of providing a device. Early identification of hearing loss and intervention are critical, as is offering additional support tailored to people with cognitive impairment (<xref ref-type="bibr" rid="ref17">Calvert et al., 2025</xref>). Recent research has advocated for stronger coordination and integration between audiology and broader healthcare services, to ensure they address the complex needs of people with hearing loss and dementia (<xref ref-type="bibr" rid="ref17">Calvert et al., 2025</xref>), especially those relying on others to manage their health. For example, in care homes, most people live with either dementia or hearing loss, and many with both, yet HA use is low (<xref ref-type="bibr" rid="ref111">RNID, 2018</xref>; <xref ref-type="bibr" rid="ref104">Prince, 2014</xref>; <xref ref-type="bibr" rid="ref141">Yamada et al., 2014</xref>; <xref ref-type="bibr" rid="ref22">Cohen-Mansfield and Taylor, 2004</xref>). Reasons for low HA use in care home settings include limited staff awareness of hearing challenges and hearing loss management options, and difficulty in discriminating symptoms and environmental and social factors (<xref ref-type="bibr" rid="ref110">Rocks and Ferguson, 2013</xref>; <xref ref-type="bibr" rid="ref117">Slaughter et al., 2014</xref>; <xref ref-type="bibr" rid="ref105">Pryce and Gooberman-Hill, 2012</xref>). Research suggests that care staff need appropriate training on maintaining HAs and using communication tactics (<xref ref-type="bibr" rid="ref24">Crosbie, 2019</xref>; <xref ref-type="bibr" rid="ref14">Broome and Green, 2026</xref>). Despite the known barriers, there are a lack of practical solutions, thus hearing loss remains largely undetected and unmanaged in this population.</p>
<p>To address the lack of specific clinical guidance, interdisciplinary practice recommendations (<xref ref-type="bibr" rid="ref66">Littlejohn et al., 2022</xref>) and best practice recommendations for the assessment and rehabilitation of hearing loss for people living with dementia (<xref ref-type="bibr" rid="ref26">Dawes, 2022</xref>) have been published. However, there are currently no known national or international standardised approaches to the assessment and management of hearing loss in this growing population. A qualitative study of UK National Health Service (NHS) audiologists identified recommendations for clinical practice including raising awareness of the importance of hearing care, providing dementia-specific training and practice guidance for audiologists and strengthening post-audiology pathway support, for example mobile clinics within the community (<xref ref-type="bibr" rid="ref17">Calvert et al., 2025</xref>).</p>
<p>While current dementia pharmacological therapies primarily aim to slow disease progression (<xref ref-type="bibr" rid="ref83">National Institute for Health and Care Excellence, 2018b</xref>), many non-pharmacological interventions are designed to improve quality of life for people living with dementia (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>). Quality of life interventions such as music or reminiscence therapy should ensure that any hearing loss is managed to maximise accessibility and effectiveness. In this context, addressing hearing loss should be viewed as part of broader health management, with benefits for communication, social engagement, quality of life, and the management of dementia-related symptoms.</p>
<p>Given the large number of individuals living with one, or both conditions, it is essential that research and healthcare efforts focus not only on risk factors and mechanisms but also on improving practical care and support for this population. A recently completed James Lind Alliance (JLA) Priority Setting Partnership (PSP) in co-existing dementia and hearing conditions identified and prioritised questions for future research in this area (<xref ref-type="bibr" rid="ref50">Heffernan et al., 2025</xref>). JLAs bring together people with lived experience and relevant professionals in partnership to identify unanswered research questions that are most important to them, shaping the future research agenda.</p>
<p>The priority questions arising from the PSP spanned diverse topics, from identifying and understanding causal mechanisms through to diagnosis and treatment. However, people living with hearing loss and/or dementia and their care partners have been identified as groups who encounter barriers to accessing clinical services and participating in research (<xref ref-type="bibr" rid="ref87">NIHR, 2022</xref>; <xref ref-type="bibr" rid="ref135">Witham et al., 2020</xref>). Barriers to research participation are compounded when people with hearing loss and dementia are also members of additional under-represented communities, such as ethnic minority groups, socio-economically disadvantaged groups, people living in care settings and the Deaf community (<xref ref-type="bibr" rid="ref87">NIHR, 2022</xref>; <xref ref-type="bibr" rid="ref135">Witham et al., 2020</xref>; <xref ref-type="bibr" rid="ref39">Flower et al., 2025</xref>).</p>
<p>Greater efforts are needed to ensure that future research in this field is inclusive of under-represented communities. Different populations may have greater risk of one or both conditions and thus require different interventions and enhanced access to health and care services. Studies included in the Lancet Commission are predominantly from high-income countries with limited representation from groups with lower levels of education, and minority ethnic groups (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>). The latest Commission report acknowledges that population attributable risk factors are highly swayed by population factors (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>). A greater focus on inclusion in future research would help ensure that findings have real-world applications, thereby enhancing the quality of care for these populations and helping reduce health inequalities. Future research should therefore focus on identifying the optimal timing of hearing intervention across the life course, determining which subgroups are most likely to benefit, and clarifying how hearing care can be most effectively integrated into existing dementia care pathways without overburdening patients or services (<xref ref-type="fig" rid="fig2">Figure 2</xref>).</p>
<p>Improving public awareness of the benefits of addressing unmanaged hearing loss is one potential component of a public health policy aimed at increasing hearing loss management for all. Integrating hearing loss education for health professionals across the care pathway is essential to ensure that they recognise the early signs of hearing loss and provide appropriate referrals or support at the earliest opportunity. An approach recommended by the World Health Organization is to offer regular hearing screenings for adults to improve early detection of hearing loss to mitigate the long-term costs for patients and health systems more generally (<xref ref-type="bibr" rid="ref136">World Health Organization, 2021</xref>), whereas UK opinion (<xref ref-type="bibr" rid="ref120">Stancel-Lewis et al., 2025</xref>) suggests that targeted, risk-stratified hearing screening offers a practical and equitable approach that is consistent with the NHS 10-year health plan for England (<xref ref-type="bibr" rid="ref32">Department of Health and Social Care, 2025</xref>).</p>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>Conceptual pathway to inform future research and practice on hearing loss in dementia.</p>
</caption>
<graphic xlink:href="frdem-05-1736003-g002.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Figure summarising current research, management, and future research priorities on hearing loss in dementia. Research highlights hearing loss as a potentially modifiable risk factor with possible mechanisms including social isolation, cognitive load, and neural changes. Management includes hearing aids, timely diagnosis, and tailored support. Future research aims to identify at-risk individuals, understand causal mechanisms, and develop evidence-based, inclusive care strategies in clinical and community settings.</alt-text>
</graphic>
</fig>
</sec>
<sec sec-type="discussion" id="sec24">
<label>6</label>
<title>Discussion</title>
<p>This review highlights the complexity of the association between hearing loss and dementia, while underscoring the uncertainties that remain in determining cause, mechanisms, and the effectiveness of hearing interventions for cognitive decline and dementia risk. Translating primarily epidemiological associations into mechanistic understanding and effective clinical or public health action remains challenging.</p>
<p>The inclusion of hearing loss as a key potentially modifiable mid-life risk factor in successive Lancet Commission reports has been instrumental in raising awareness of the importance of hearing health for dementia risk (<xref ref-type="bibr" rid="ref70">Livingston et al., 2017</xref>; <xref ref-type="bibr" rid="ref120">Stancel-Lewis et al., 2025</xref>; <xref ref-type="bibr" rid="ref97">Parmar et al., 2025</xref>). However, population-attributable fraction (PAF) estimates are model-dependent, context-specific, and rely on assumptions that are not yet fully supported by experimental evidence (<xref ref-type="bibr" rid="ref77">Mansournia and Altman, 2018</xref>; <xref ref-type="bibr" rid="ref54">Ishak et al., 2025</xref>). A risk for the field is that an oversimplified interpretation of these estimates may lead to the conclusion that managing hearing loss can completely remove the risk posed by it, eliminating a proportion of dementia cases. Responsible communication is therefore essential to ensure messaging is framed in the context of the available evidence to minimise any negative impacts on unrealistic expectations, help-seeking, and stigma for hearing loss and dementia (<xref ref-type="bibr" rid="ref12">British Society of Audiology, 2024</xref>; <xref ref-type="bibr" rid="ref9">Blustein et al., 2023</xref>; <xref ref-type="bibr" rid="ref28">Dawes and Munro, 2024</xref>).</p>
<p>Evidence shows that the association between dementia and hearing loss is biologically plausible; supported by multiple hypothesised mechanisms. However these may not operate in isolation. Multiple, potentially interactive mechanisms likely link hearing loss with dementia. These include sensory deprivation, increased cognitive load, vascular and neurodegenerative processes, with shared genetic and biological risk factors; all of which are likely to contribute, rather than underly a single unifying pathway. Importantly, the relative contribution of these mechanisms may vary across individuals and across the life course, influenced by factors such as age, sex, cardiovascular health, and timing of the intervention. In particular, mechanisms associated with midlife hearing loss are more consistent with long-term causal pathways, whereas associations observed in later life may increasingly reflect prodromal neurodegenerative processes or shared ageing-related pathology. The recently proposed &#x2018;cause&#x2013;catalyst&#x2013;consequence&#x2019; framework provides a valuable integrative model for conceptualising these interacting pathways and may help guide future hypothesis-driven research (<xref ref-type="bibr" rid="ref51">Homans et al., 2017</xref>).</p>
<p>Despite a wealth of associative evidence, we lack substantive experimental evidence for hearing interventions to prevent or meaningfully slow cognitive decline in the general population. Importantly, studies have begun to identify meaningful targeting of hearing intervention and support (<xref ref-type="bibr" rid="ref145">Yu et al., 2025</xref>). In the meantime, hearing interventions hearing interventions remain clinically valuable for improving communication, social participation, and overall wellbeing. These outcomes are intrinsically important to people living with dementia and their families (<xref ref-type="bibr" rid="ref142">Yang et al., 2022</xref>; <xref ref-type="bibr" rid="ref72">Machado et al., 2024</xref>; <xref ref-type="bibr" rid="ref123">Tang et al., 2025</xref>; <xref ref-type="bibr" rid="ref82">National Institute for Health and Care Excellence, 2018a</xref>; <xref ref-type="bibr" rid="ref109">Ray et al., 2019</xref>; <xref ref-type="bibr" rid="ref76">Mamo et al., 2017</xref>; <xref ref-type="bibr" rid="ref75">Mamo, 2018</xref>). The ethical and practical challenges of conducting long-term trials in this area suggest that innovative study designs will be required to advance the evidence base.</p>
<p>The comorbidity of hearing loss and dementia is high. While dementia drug therapies primarily aim to slow disease progression, many non-pharmacological interventions focus on improving quality of life, wellbeing and social engagement (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>). Failure to identify and manage hearing loss may therefore limit the accessibility and effectiveness of these approaches. In this context, addressing hearing loss should be viewed as an integral component of holistic dementia care, with benefits for communication, participation, behavioural symptoms, and quality of life, even in the absence of disease-modifying effects.</p>
<p>A recurring limitation across the literature is the under-representation of diverse populations, including people from low- and middle-income countries, minority ethnic groups, socioeconomically disadvantaged communities, care home residents, and Deaf communities (<xref ref-type="bibr" rid="ref68">Livingston et al., 2024</xref>; <xref ref-type="bibr" rid="ref83">National Institute for Health and Care Excellence, 2018b</xref>; <xref ref-type="bibr" rid="ref50">Heffernan et al., 2025</xref>). Given the high global prevalence of both hearing loss and dementia, and the substantial variation in access to hearing care, improving inclusivity is essential for ensuring that research findings translate into equitable public health and clinical practice.</p>
<p>The James Lind Alliance Priority Setting Partnership in coexisting dementia and hearing conditions highlights the importance of research questions that matter to people with lived experience, spanning mechanisms, diagnosis, intervention, and service delivery (<xref ref-type="bibr" rid="ref26">Dawes, 2022</xref>).</p>
</sec>
<sec sec-type="conclusions" id="sec25">
<label>7</label>
<title>Conclusion</title>
<p>Hearing loss is consistently associated with increased risk of cognitive decline and dementia, although the mechanisms underlying this relationship remain incompletely understood. Current evidence suggests that multiple biological and cognitive pathways likely interact across the life course. Clarifying these pathways and identifying individuals most likely to benefit from intervention will be essential to inform future prevention and management strategies. Progress in this field will depend on interdisciplinary collaboration, inclusive research practices, and a balanced narrative that recognises both the promise and limitations of the evidence to support the role of hearing loss management in dementia prevention and care.</p>
</sec>
</body>
<back>
<sec sec-type="author-contributions" id="sec26">
<title>Author contributions</title>
<p>EB: Visualization, Funding acquisition, Data curation, Project administration, Writing &#x2013; original draft, Formal analysis, Investigation, Conceptualization, Methodology, Writing &#x2013; review &#x0026; editing, Supervision. SC: Funding acquisition, Writing &#x2013; review &#x0026; editing, Writing &#x2013; original draft, Methodology, Conceptualization, Investigation, Supervision, Data curation. EH: Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing, Conceptualization, Investigation, Funding acquisition, Supervision. HH: Investigation, Writing &#x2013; review &#x0026; editing, Supervision, Funding acquisition, Writing &#x2013; original draft, Conceptualization. AK: Conceptualization, Investigation, Visualization, Writing &#x2013; review &#x0026; editing, Writing &#x2013; original draft, Data curation, Supervision. VP: Conceptualization, Visualization, Writing &#x2013; review &#x0026; editing, Writing &#x2013; original draft. JS: Writing &#x2013; review &#x0026; editing, Writing &#x2013; original draft, Conceptualization. JS-L: Writing &#x2013; review &#x0026; editing, Investigation, Writing &#x2013; original draft. TD: Writing &#x2013; original draft, Visualization, Conceptualization, Supervision, Project administration, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec sec-type="COI-statement" id="sec27">
<title>Conflict of interest</title>
<p>HH reports a speaker honoraria and travel expenses from GN Hearing A/S. This party had no influence in any part of the preparation of this review. EB and HH report a research grant from WS Audiology A/S.</p>
<p>The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="ai-statement" id="sec28">
<title>Generative AI statement</title>
<p>The author(s) declared that Generative AI was not used in the creation of this manuscript.</p>
<p>Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.</p>
</sec>
<sec sec-type="disclaimer" id="sec29">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<ref-list>
<title>References</title>
<ref id="ref1"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Abidin</surname><given-names>F. N. Z.</given-names></name> <name><surname>Wells</surname><given-names>H. R. R.</given-names></name> <name><surname>Altmann</surname><given-names>A.</given-names></name> <name><surname>Dawson</surname><given-names>S. J.</given-names></name></person-group> (<year>2021</year>). <article-title>Hearing difficulty is linked to Alzheimer&#x2019;s disease by common genetic vulnerability, not shared genetic architecture</article-title>. <source>npj Aging Mech. Dis.</source> <volume>7</volume>:<fpage>17</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s41514-021-00069-4</pub-id>, <pub-id pub-id-type="pmid">34294723</pub-id></mixed-citation></ref>
<ref id="ref2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Amieva</surname><given-names>H.</given-names></name> <name><surname>Ouvrard</surname><given-names>C.</given-names></name> <name><surname>Giulioli</surname><given-names>C.</given-names></name> <name><surname>Meillon</surname><given-names>C.</given-names></name> <name><surname>Rullier</surname><given-names>L.</given-names></name> <name><surname>Dartigues</surname><given-names>J. F.</given-names></name></person-group> (<year>2015</year>). <article-title>Self-reported hearing loss, hearing aids, and cognitive decline in elderly adults: a 25-year study</article-title>. <source>J. Am. Geriatr. Soc.</source> <volume>63</volume>, <fpage>2099</fpage>&#x2013;<lpage>2104</lpage>. doi: <pub-id pub-id-type="doi">10.1111/jgs.13649</pub-id>, <pub-id pub-id-type="pmid">26480972</pub-id></mixed-citation></ref>
<ref id="ref3"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Amieva</surname><given-names>H.</given-names></name> <name><surname>Ouvrard</surname><given-names>C.</given-names></name> <name><surname>Meillon</surname><given-names>C.</given-names></name> <name><surname>Rullier</surname><given-names>L.</given-names></name> <name><surname>Dartigues</surname><given-names>J. F.</given-names></name></person-group> (<year>2018</year>). <article-title>Death, depression, disability, and dementia associated with self-reported hearing problems: a 25-year study</article-title>. <source>J. Gerontol. A Biol. Sci. Med. Sci.</source> <volume>73</volume>, <fpage>1383</fpage>&#x2013;<lpage>1389</lpage>. doi: <pub-id pub-id-type="doi">10.1093/gerona/glx250</pub-id>, <pub-id pub-id-type="pmid">29304204</pub-id></mixed-citation></ref>
<ref id="ref4"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Armstrong</surname><given-names>N. M.</given-names></name> <name><surname>An</surname><given-names>Y.</given-names></name> <name><surname>Doshi</surname><given-names>J.</given-names></name> <name><surname>Erus</surname><given-names>G.</given-names></name> <name><surname>Ferrucci</surname><given-names>L.</given-names></name> <name><surname>Davatzikos</surname><given-names>C.</given-names></name> <etal/></person-group>. (<year>2019</year>). <article-title>Association of midlife hearing impairment with late-life temporal lobe volume loss</article-title>. <source>JAMA Otolaryngol. Head Neck Surg.</source> <volume>145</volume>, <fpage>794</fpage>&#x2013;<lpage>802</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jamaoto.2019.1610</pub-id>, <pub-id pub-id-type="pmid">31268512</pub-id></mixed-citation></ref>
<ref id="ref5"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Azeem</surname><given-names>A.</given-names></name> <name><surname>Julleekeea</surname><given-names>A.</given-names></name> <name><surname>Knight</surname><given-names>B.</given-names></name> <name><surname>Sohail</surname><given-names>I.</given-names></name> <name><surname>Bruyns-Haylett</surname><given-names>M.</given-names></name> <name><surname>Sastre</surname><given-names>M.</given-names></name></person-group> (<year>2023</year>). <article-title>Hearing loss and its link to cognitive impairment and dementia</article-title>. <source>Front. Dementia</source> <volume>2</volume>:<fpage>1199319</fpage>. doi: <pub-id pub-id-type="doi">10.3389/frdem.2023.1199319</pub-id>, <pub-id pub-id-type="pmid">39081997</pub-id></mixed-citation></ref>
<ref id="ref6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Azevedo</surname><given-names>L. V.d. S.</given-names></name></person-group> (<year>2021</year>). <article-title>Impact of social isolation on people with dementia and their family caregivers</article-title>. <source>J Alzheimer's Dis</source> <volume>81</volume>, <fpage>607</fpage>&#x2013;<lpage>617</lpage> doi: <pub-id pub-id-type="doi">10.3233/JAD-201580</pub-id></mixed-citation></ref>
<ref id="ref7"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baloyannis</surname><given-names>S. J.</given-names></name> <name><surname>Mauroudis</surname><given-names>I.</given-names></name> <name><surname>Manolides</surname><given-names>S. L.</given-names></name> <name><surname>Manolides</surname><given-names>L. S.</given-names></name></person-group> (<year>2009</year>). <article-title>Synaptic alterations in the medial geniculate bodies and the inferior colliculi in Alzheimer's disease: a Golgi and electron microscope study</article-title>. <source>Acta Otolaryngol.</source> <volume>129</volume>, <fpage>416</fpage>&#x2013;<lpage>418</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00016480802579074</pub-id>, <pub-id pub-id-type="pmid">19116791</pub-id></mixed-citation></ref>
<ref id="ref8"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Billig</surname><given-names>A. J.</given-names></name> <name><surname>Lad</surname><given-names>M.</given-names></name> <name><surname>Sedley</surname><given-names>W.</given-names></name> <name><surname>Griffiths</surname><given-names>T. D.</given-names></name></person-group> (<year>2022</year>). <article-title>The hearing hippocampus</article-title>. <source>Prog. Neurobiol.</source> <volume>218</volume>:<fpage>102326</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.pneurobio.2022.102326</pub-id>, <pub-id pub-id-type="pmid">35870677</pub-id></mixed-citation></ref>
<ref id="ref9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Blustein</surname><given-names>J.</given-names></name> <name><surname>Weinstein</surname><given-names>B. E.</given-names></name> <name><surname>Chodosh</surname><given-names>J.</given-names></name></person-group> (<year>2023</year>). <article-title>Messaging clearly and effectively about hearing loss and increased dementia risk</article-title>. <source>JAMA Otolaryngol. Head Neck Surg.</source> <volume>149</volume>, <fpage>862</fpage>&#x2013;<lpage>863</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jamaoto.2023.2561</pub-id>, <pub-id pub-id-type="pmid">37615946</pub-id></mixed-citation></ref>
<ref id="ref10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brenowitz</surname><given-names>W. D.</given-names></name> <name><surname>Filshtein</surname><given-names>T. J.</given-names></name> <name><surname>Yaffe</surname><given-names>K.</given-names></name> <name><surname>Walter</surname><given-names>S.</given-names></name> <name><surname>Ackley</surname><given-names>S. F.</given-names></name> <name><surname>Hoffmann</surname><given-names>T. J.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Association of genetic risk for Alzheimer disease and hearing impairment</article-title>. <source>Neurology</source> <volume>95</volume>, <fpage>e2225</fpage>&#x2013;<lpage>e2234</lpage>. doi: <pub-id pub-id-type="doi">10.1212/WNL.0000000000010709</pub-id>, <pub-id pub-id-type="pmid">32878991</pub-id></mixed-citation></ref>
<ref id="ref11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brenowitz</surname><given-names>W. D.</given-names></name> <name><surname>Kaup</surname><given-names>A. R.</given-names></name> <name><surname>Lin</surname><given-names>F. R.</given-names></name> <name><surname>Yaffe</surname><given-names>K.</given-names></name></person-group> (<year>2019</year>). <article-title>Multiple sensory impairment is associated with increased risk of dementia among black and white older adults</article-title>. <source>J. Gerontol. Ser. A</source> <volume>74</volume>, <fpage>890</fpage>&#x2013;<lpage>896</lpage>. doi: <pub-id pub-id-type="doi">10.1093/gerona/gly264</pub-id>, <pub-id pub-id-type="pmid">30452551</pub-id></mixed-citation></ref>
<ref id="ref12"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll1">British Society of Audiology</collab></person-group>. <article-title>The British Society of Hearing Aid Audiologists</article-title>, <source>The link between adult-onset hearing loss and dementia</source>. Bathgate, Scotland, British Society of Audiology. (<year>2024</year>).</mixed-citation></ref>
<ref id="ref13"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Broome</surname><given-names>E.</given-names></name> <name><surname>Burgon</surname><given-names>C.</given-names></name> <name><surname>Heffernan</surname><given-names>E.</given-names></name> <name><surname>Dening</surname><given-names>T.</given-names></name> <name><surname>Calvert</surname><given-names>S.</given-names></name> <name><surname>Rajasingam</surname><given-names>S.</given-names></name></person-group> (<year>2023</year>). <article-title>When hearing loss co&#x2011;occurs with dementia: challenges and opportunities in diagnosis and management. In Updates on Hearing Loss and its Rehabilitation. Eds. A. Ciorba and S. Hatzopoulos. London, UK: IntechOpen</article-title>, p.<fpage>85</fpage>&#x2013;<lpage>111</lpage>. doi: <pub-id pub-id-type="doi">10.5772/intechopen.1003179</pub-id></mixed-citation></ref>
<ref id="ref14"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Broome</surname><given-names>E. E.</given-names></name> <name><surname>Green</surname><given-names>A.</given-names></name></person-group> (<year>2026</year>). <article-title>Management of co-existing dementia and hearing loss in social care settings: a focus group study</article-title>. <source>Dementia</source> <volume>1</volume>:<fpage>14713012251356010</fpage>. doi: <pub-id pub-id-type="doi">10.1177/14713012251356010</pub-id></mixed-citation></ref>
<ref id="ref15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bucholc</surname><given-names>M.</given-names></name></person-group> (<year>2022</year>). <article-title>The impact of hearing impairment and hearing aid use on progression to mild cognitive impairment in cognitively healthy adults: an observational cohort study</article-title>. <source>Alzheimers Dement (N Y)</source> <volume>8</volume>:<fpage>e12248</fpage>.</mixed-citation></ref>
<ref id="ref16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bucholc</surname><given-names>M.</given-names></name> <name><surname>McClean</surname><given-names>P. L.</given-names></name> <name><surname>Bauermeister</surname><given-names>S.</given-names></name> <name><surname>Todd</surname><given-names>S.</given-names></name> <name><surname>Ding</surname><given-names>X.</given-names></name> <name><surname>Ye</surname><given-names>Q.</given-names></name> <etal/></person-group>. (<year>2021</year>). <article-title>Association of the use of hearing aids with the conversion from mild cognitive impairment to dementia and progression of dementia: a longitudinal retrospective study</article-title>. <source>Alzheimers Dement (N Y)</source> <volume>7</volume>:<fpage>e12122</fpage>. doi: <pub-id pub-id-type="doi">10.1002/trc2.12122</pub-id>, <pub-id pub-id-type="pmid">33614893</pub-id></mixed-citation></ref>
<ref id="ref17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Calvert</surname><given-names>S.</given-names></name> <name><surname>Chitty</surname><given-names>A.</given-names></name> <name><surname>Langdon</surname><given-names>A.</given-names></name> <name><surname>Broome</surname><given-names>E.</given-names></name> <name><surname>Henshaw</surname><given-names>H.</given-names></name> <name><surname>Somerset</surname><given-names>S.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>Understanding the audiological care of patients with co-existing dementia or mild cognitive impairment and hearing loss in the United Kingdom National Health Service: a qualitative study</article-title>. <source>PLoS One</source> <volume>20</volume>:<fpage>e0327248</fpage>. doi: <pub-id pub-id-type="doi">10.1371/journal.pone.0327248</pub-id>, <pub-id pub-id-type="pmid">40561168</pub-id></mixed-citation></ref>
<ref id="ref18"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cantuaria</surname><given-names>M. L.</given-names></name></person-group> (<year>2024</year>). <article-title>Hearing loss, hearing aid use, and risk of dementia in older adults</article-title>. <source>JAMA Otolaryngol. Head Neck Surg.</source> <volume>150</volume>, <fpage>157</fpage>&#x2013;<lpage>164</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jamaoto.2023.3509</pub-id></mixed-citation></ref>
<ref id="ref19"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carasek</surname><given-names>N.</given-names></name> <name><surname>Lamounier</surname><given-names>P.</given-names></name> <name><surname>Maldi</surname><given-names>I. G.</given-names></name> <name><surname>Bernardes</surname><given-names>M. N. D.</given-names></name> <name><surname>Ramos</surname><given-names>H. V. L.</given-names></name> <name><surname>Costa</surname><given-names>C. C.</given-names></name> <etal/></person-group>. (<year>2022</year>). <article-title>Is there benefit from the use of cochlear implants and hearing aids in cognition for older adults? A systematic review</article-title>. <source>Front. Epidemiol.</source> <volume>2</volume>:<fpage>934750</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fepid.2022.934750</pub-id>, <pub-id pub-id-type="pmid">38455285</pub-id></mixed-citation></ref>
<ref id="ref20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cenquizca</surname><given-names>L. A.</given-names></name> <name><surname>Swanson</surname><given-names>L. W.</given-names></name></person-group> (<year>2007</year>). <article-title>Spatial organization of direct hippocampal field CA1 axonal projections to the rest of the cerebral cortex</article-title>. <source>Brain Res. Rev.</source> <volume>56</volume>, <fpage>1</fpage>&#x2013;<lpage>26</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.brainresrev.2007.05.002</pub-id>, <pub-id pub-id-type="pmid">17559940</pub-id></mixed-citation></ref>
<ref id="ref21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cheng</surname><given-names>L.</given-names></name> <name><surname>Wang</surname><given-names>S. H.</given-names></name> <name><surname>Chen</surname><given-names>Q. C.</given-names></name> <name><surname>Liao</surname><given-names>X. M.</given-names></name></person-group> (<year>2011</year>). <article-title>Moderate noise induced cognition impairment of mice and its underlying mechanisms</article-title>. <source>Physiol. Behav.</source> <volume>104</volume>, <fpage>981</fpage>&#x2013;<lpage>988</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.physbeh.2011.06.018</pub-id>, <pub-id pub-id-type="pmid">21726571</pub-id></mixed-citation></ref>
<ref id="ref22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cohen-Mansfield</surname><given-names>J.</given-names></name> <name><surname>Taylor</surname><given-names>J. W.</given-names></name></person-group> (<year>2004</year>). <article-title>Hearing aid use in nursing homes, part 1: prevalence rates of hearing impairment and hearing aid use</article-title>. <source>J. Am. Med. Dir. Assoc.</source> <volume>5</volume>, <fpage>283</fpage>&#x2013;<lpage>288</lpage>. doi: <pub-id pub-id-type="doi">10.1016/s1525-8610(04)70017-1</pub-id>, <pub-id pub-id-type="pmid">15357885</pub-id></mixed-citation></ref>
<ref id="ref23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cosh</surname><given-names>S.</given-names></name> <name><surname>Helmer</surname><given-names>C.</given-names></name> <name><surname>Delcourt</surname><given-names>C.</given-names></name> <name><surname>Robins</surname><given-names>T. G.</given-names></name> <name><surname>Tully</surname><given-names>P. J.</given-names></name></person-group> (<year>2019</year>). <article-title>Depression in elderly patients with hearing loss: current perspectives</article-title>. <source>Clin. Interv. Aging</source> <volume>14</volume>, <fpage>1471</fpage>&#x2013;<lpage>1480</lpage>. doi: <pub-id pub-id-type="doi">10.2147/CIA.S195824</pub-id>, <pub-id pub-id-type="pmid">31616138</pub-id></mixed-citation></ref>
<ref id="ref24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Crosbie</surname><given-names>B.</given-names></name></person-group> (<year>2019</year>). <article-title>Giving permission to care for people with dementia in residential homes: learning from a realist synthesis of hearing-related communication</article-title>. <source>BMC Med.</source> <volume>17</volume>, <fpage>1</fpage>&#x2013;<lpage>16</lpage>. doi: <pub-id pub-id-type="doi">10.1186/s12916-019-1286-9</pub-id></mixed-citation></ref>
<ref id="ref25"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cuoco</surname><given-names>S.</given-names></name> <name><surname>Cappiello</surname><given-names>A.</given-names></name> <name><surname>Scarpa</surname><given-names>A.</given-names></name> <name><surname>Troisi</surname><given-names>D.</given-names></name> <name><surname>Autuori</surname><given-names>M.</given-names></name> <name><surname>Ponticorvo</surname><given-names>S.</given-names></name> <etal/></person-group>. (<year>2021</year>). <article-title>Neuropsychological profile of hearing-impaired patients and the effect of hearing aid on cognitive functions: an exploratory study</article-title>. <source>Sci. Rep.</source> <volume>11</volume>:<fpage>9384</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s41598-021-88487-y</pub-id>, <pub-id pub-id-type="pmid">33931670</pub-id></mixed-citation></ref>
<ref id="ref26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dawes</surname><given-names>P.</given-names></name></person-group> (<year>2022</year>). <article-title>Hearing assessment and rehabilitation for people living with dementia</article-title>. <source>Ear Hear.</source> <volume>43</volume>, <fpage>1089</fpage>&#x2013;<lpage>1102</lpage>. doi: <pub-id pub-id-type="doi">10.1097/aud.0000000000001174</pub-id></mixed-citation></ref>
<ref id="ref27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dawes</surname><given-names>P.</given-names></name> <name><surname>Cruickshanks</surname><given-names>K. J.</given-names></name> <name><surname>Fischer</surname><given-names>M. E.</given-names></name> <name><surname>Klein</surname><given-names>B. E. K.</given-names></name> <name><surname>Klein</surname><given-names>R.</given-names></name> <name><surname>Nondahl</surname><given-names>D. M.</given-names></name></person-group> (<year>2015</year>). <article-title>Hearing-aid use and long-term health outcomes: hearing handicap, mental health, social engagement, cognitive function, physical health, and mortality</article-title>. <source>Int. J. Audiol.</source> <volume>54</volume>, <fpage>838</fpage>&#x2013;<lpage>844</lpage>. doi: <pub-id pub-id-type="doi">10.3109/14992027.2015.1059503</pub-id>, <pub-id pub-id-type="pmid">26140300</pub-id></mixed-citation></ref>
<ref id="ref28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dawes</surname><given-names>P.</given-names></name> <name><surname>Munro</surname><given-names>K. J.</given-names></name></person-group> (<year>2024</year>). <article-title>Hearing loss and dementia: where to from Here?</article-title> <source>Ear Hear.</source> <volume>45</volume>, <fpage>529</fpage>&#x2013;<lpage>536</lpage>. doi: <pub-id pub-id-type="doi">10.1097/AUD.0000000000001494</pub-id>, <pub-id pub-id-type="pmid">38379156</pub-id></mixed-citation></ref>
<ref id="ref29"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dawes</surname><given-names>P.</given-names></name> <name><surname>Wolski</surname><given-names>L.</given-names></name> <name><surname>Himmelsbach</surname><given-names>I.</given-names></name> <name><surname>Regan</surname><given-names>J.</given-names></name> <name><surname>Leroi</surname><given-names>I.</given-names></name></person-group> (<year>2019</year>). <article-title>Interventions for hearing and vision impairment to improve outcomes for people with dementia: a scoping review</article-title>. <source>Int. Psychogeriatr.</source> <volume>31</volume>, <fpage>203</fpage>&#x2013;<lpage>221</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S1041610218000728</pub-id>, <pub-id pub-id-type="pmid">30244688</pub-id></mixed-citation></ref>
<ref id="ref30"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Deal</surname><given-names>J. A.</given-names></name></person-group> (<year>2017</year>). <article-title>Hearing impairment and incident dementia and cognitive decline in older adults: the health ABC study</article-title>. <source>J. Gerontol. A Biol. Sci. Med. Sci.</source> <volume>72</volume>, <fpage>703</fpage>&#x2013;<lpage>709</lpage>. doi: <pub-id pub-id-type="doi">10.1093/gerona/glw069</pub-id></mixed-citation></ref>
<ref id="ref31"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Deal</surname><given-names>J. A.</given-names></name> <name><surname>Sharrett</surname><given-names>A. R.</given-names></name> <name><surname>Albert</surname><given-names>M. S.</given-names></name> <name><surname>Coresh</surname><given-names>J.</given-names></name> <name><surname>Mosley</surname><given-names>T. H.</given-names></name> <name><surname>Knopman</surname><given-names>D.</given-names></name> <etal/></person-group>. (<year>2015</year>). <article-title>Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study</article-title>. <source>Am. J. Epidemiol.</source> <volume>181</volume>, <fpage>680</fpage>&#x2013;<lpage>690</lpage>. doi: <pub-id pub-id-type="doi">10.1093/aje/kwu333</pub-id>, <pub-id pub-id-type="pmid">25841870</pub-id></mixed-citation></ref>
<ref id="ref32"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll2">Department of Health and Social Care</collab></person-group> <source>10 year health plan for England: Fit for the future</source>. United Kingdom, Department of Health and Social Care. (<year>2025</year>)</mixed-citation></ref>
<ref id="ref33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Desai</surname><given-names>R.</given-names></name> <name><surname>John</surname><given-names>A.</given-names></name> <name><surname>Stott</surname><given-names>J.</given-names></name> <name><surname>Charlesworth</surname><given-names>G.</given-names></name></person-group> (<year>2020</year>). <article-title>Living alone and risk of dementia: a systematic review and meta-analysis</article-title>. <source>Ageing Res. Rev.</source> <volume>62</volume>:<fpage>101122</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.arr.2020.101122</pub-id>, <pub-id pub-id-type="pmid">32659336</pub-id></mixed-citation></ref>
<ref id="ref34"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dupuis</surname><given-names>K.</given-names></name></person-group> (<year>2015</year>). <article-title>Effects of hearing and vision impairments on the Montreal cognitive assessment</article-title>. <source>Aging Neuropsychol. Cogn.</source> <volume>22</volume>, <fpage>413</fpage>&#x2013;<lpage>437</lpage>. doi: <pub-id pub-id-type="doi">10.1080/13825585.2014.968084</pub-id></mixed-citation></ref>
<ref id="ref35"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eckert</surname><given-names>M. A.</given-names></name></person-group> (<year>2013</year>). <article-title>White matter hyperintensities predict low frequency hearing in older adults</article-title>. <source>J. Assoc. Res. Otolaryngol.</source> <volume>14</volume>, <fpage>425</fpage>&#x2013;<lpage>433</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s10162-013-0381-4</pub-id></mixed-citation></ref>
<ref id="ref36"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eisenmenger</surname><given-names>L. B.</given-names></name> <name><surname>Peret</surname><given-names>A.</given-names></name> <name><surname>Famakin</surname><given-names>B. M.</given-names></name> <name><surname>Spahic</surname><given-names>A.</given-names></name> <name><surname>Roberts</surname><given-names>G. S.</given-names></name> <name><surname>Bockholt</surname><given-names>J. H.</given-names></name> <etal/></person-group>. (<year>2023</year>). <article-title>Vascular contributions to Alzheimer's disease</article-title>. <source>Transl. Res.</source> <volume>254</volume>, <fpage>41</fpage>&#x2013;<lpage>53</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.trsl.2022.12.003</pub-id>, <pub-id pub-id-type="pmid">36529160</pub-id></mixed-citation></ref>
<ref id="ref37"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Esiri</surname><given-names>M. M.</given-names></name> <name><surname>Pearson</surname><given-names>R.</given-names></name> <name><surname>Powell</surname><given-names>T.</given-names></name></person-group> (<year>1986</year>). <article-title>The cortex of the primary auditory area in Alzheimer's disease</article-title>. <source>Brain Res.</source> <volume>366</volume>, <fpage>385</fpage>&#x2013;<lpage>387</lpage>.</mixed-citation></ref>
<ref id="ref38"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ferretti</surname><given-names>M. T.</given-names></name></person-group> (<year>2018</year>). <article-title>Sex differences in Alzheimer disease - the gateway to precision medicine</article-title>. <source>Nat. Rev. Neurol.</source> <volume>14</volume>, <fpage>457</fpage>&#x2013;<lpage>469</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41582-018-0032-9</pub-id></mixed-citation></ref>
<ref id="ref39"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Flower</surname><given-names>I.</given-names></name> <name><surname>Heffernan</surname><given-names>E.</given-names></name> <name><surname>Dening</surname><given-names>T.</given-names></name></person-group> (<year>2025</year>). <article-title>Dementia and the deaf community: prevalence, assessment and management in people with hearing loss since childhood</article-title>. <source>Aging Ment. Health</source> <volume>29</volume>, <fpage>757</fpage>&#x2013;<lpage>766</lpage>. doi: <pub-id pub-id-type="doi">10.1080/13607863.2024.2430533</pub-id>, <pub-id pub-id-type="pmid">39578948</pub-id></mixed-citation></ref>
<ref id="ref40"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ford</surname><given-names>A. H.</given-names></name> <name><surname>Hankey</surname><given-names>G. J.</given-names></name> <name><surname>Yeap</surname><given-names>B. B.</given-names></name> <name><surname>Golledge</surname><given-names>J.</given-names></name> <name><surname>Flicker</surname><given-names>L.</given-names></name> <name><surname>Almeida</surname><given-names>O. P.</given-names></name></person-group> (<year>2018</year>). <article-title>Hearing loss and the risk of dementia in later life</article-title>. <source>Maturitas</source> <volume>112</volume>, <fpage>1</fpage>&#x2013;<lpage>11</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.maturitas.2018.03.004</pub-id>, <pub-id pub-id-type="pmid">29704910</pub-id></mixed-citation></ref>
<ref id="ref41"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>F&#x00FC;llgrabe</surname><given-names>C.</given-names></name></person-group> (<year>2020</year>). <article-title>When hearing loss masquerades as cognitive decline, in journal of neurology, Neurosurgery &#x0026; Psychiatry</article-title>. <source>J. Neurol. Neurosurg. Psychiatry</source>, <volume>91</volume>, <fpage>1248</fpage>&#x2013;<lpage>1248</lpage>. doi: <pub-id pub-id-type="doi">10.1136/jnnp-2020-324707</pub-id></mixed-citation></ref>
<ref id="ref42"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gallacher</surname><given-names>J.</given-names></name> <name><surname>Ilubaera</surname><given-names>V.</given-names></name> <name><surname>Ben-Shlomo</surname><given-names>Y.</given-names></name> <name><surname>Bayer</surname><given-names>A.</given-names></name> <name><surname>Fish</surname><given-names>M.</given-names></name> <name><surname>Babisch</surname><given-names>W.</given-names></name> <etal/></person-group>. (<year>2012</year>). <article-title>Auditory threshold, phonologic demand, and incident dementia</article-title>. <source>Neurology</source> <volume>79</volume>, <fpage>1583</fpage>&#x2013;<lpage>1590</lpage>. doi: <pub-id pub-id-type="doi">10.1212/WNL.0b013e31826e263d</pub-id>, <pub-id pub-id-type="pmid">23019269</pub-id></mixed-citation></ref>
<ref id="ref43"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gates</surname><given-names>G. A.</given-names></name></person-group> (<year>2008</year>). <article-title>Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia</article-title>. <source>Arch. Otolaryngol. Head Neck Surg.</source> <volume>134</volume>, <fpage>771</fpage>&#x2013;<lpage>777</lpage>. doi: <pub-id pub-id-type="doi">10.1001/archotol.134.7.771</pub-id></mixed-citation></ref>
<ref id="ref44"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Glick</surname><given-names>H. A.</given-names></name> <name><surname>Sharma</surname><given-names>A.</given-names></name></person-group> (<year>2020</year>). <article-title>Cortical neuroplasticity and cognitive function in early-stage, mild-moderate hearing loss: evidence of neurocognitive benefit from hearing aid use</article-title>. <source>Front. Neurosci.</source> <volume>14</volume>:<fpage>93</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fnins.2020.00093</pub-id>, <pub-id pub-id-type="pmid">32132893</pub-id></mixed-citation></ref>
<ref id="ref45"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Golob</surname><given-names>E.</given-names></name> <name><surname>Ringman</surname><given-names>J. M.</given-names></name> <name><surname>Irimajiri</surname><given-names>R.</given-names></name> <name><surname>Bright</surname><given-names>S.</given-names></name> <name><surname>Schaffer</surname><given-names>B.</given-names></name> <name><surname>Medina</surname><given-names>L. D.</given-names></name> <etal/></person-group>. (<year>2009</year>). <article-title>Cortical event-related potentials in preclinical familial Alzheimer disease</article-title>. <source>Neurology</source> <volume>73</volume>, <fpage>1649</fpage>&#x2013;<lpage>1655</lpage>. doi: <pub-id pub-id-type="doi">10.1212/WNL.0b013e3181c1de77</pub-id>, <pub-id pub-id-type="pmid">19917987</pub-id></mixed-citation></ref>
<ref id="ref46"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gopinath</surname><given-names>B.</given-names></name> <name><surname>Hickson</surname><given-names>L.</given-names></name> <name><surname>Schneider</surname><given-names>J.</given-names></name> <name><surname>McMahon</surname><given-names>C. M.</given-names></name> <name><surname>Burlutsky</surname><given-names>G.</given-names></name> <name><surname>Leeder</surname><given-names>S. R.</given-names></name> <etal/></person-group>. (<year>2012</year>). <article-title>Hearing-impaired adults are at increased risk of experiencing emotional distress and social engagement restrictions five years later</article-title>. <source>Age Ageing</source> <volume>41</volume>, <fpage>618</fpage>&#x2013;<lpage>623</lpage>. doi: <pub-id pub-id-type="doi">10.1093/ageing/afs058</pub-id>, <pub-id pub-id-type="pmid">22591986</pub-id></mixed-citation></ref>
<ref id="ref47"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Griffiths</surname><given-names>T. D.</given-names></name> <name><surname>Lad</surname><given-names>M.</given-names></name> <name><surname>Kumar</surname><given-names>S.</given-names></name> <name><surname>Holmes</surname><given-names>E.</given-names></name> <name><surname>McMurray</surname><given-names>B.</given-names></name> <name><surname>Maguire</surname><given-names>E. A.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>How can hearing loss cause dementia?</article-title> <source>Neuron</source> <volume>108</volume>, <fpage>401</fpage>&#x2013;<lpage>412</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.neuron.2020.08.003</pub-id>, <pub-id pub-id-type="pmid">32871106</pub-id></mixed-citation></ref>
<ref id="ref48"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haile</surname><given-names>L. M.</given-names></name> <name><surname>Orji</surname><given-names>A. U.</given-names></name> <name><surname>Reavis</surname><given-names>K. M.</given-names></name> <name><surname>Briant</surname><given-names>P. S.</given-names></name> <name><surname>Lucas</surname><given-names>K. M.</given-names></name> <name><surname>Alahdab</surname><given-names>F.</given-names></name> <etal/></person-group>. (<year>2024</year>). <article-title>Hearing loss prevalence, years lived with disability, and hearing aid use in the United States from 1990 to 2019: findings from the global burden of disease study</article-title>. <source>Ear Hear.</source> <volume>45</volume>, <fpage>257</fpage>&#x2013;<lpage>267</lpage>. doi: <pub-id pub-id-type="doi">10.1097/AUD.0000000000001420</pub-id>, <pub-id pub-id-type="pmid">37712826</pub-id></mixed-citation></ref>
<ref id="ref49"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hardy</surname><given-names>C. J.</given-names></name> <name><surname>Marshall</surname><given-names>C. R.</given-names></name> <name><surname>Golden</surname><given-names>H. L.</given-names></name> <name><surname>Clark</surname><given-names>C. N.</given-names></name> <name><surname>Mummery</surname><given-names>C. J.</given-names></name> <name><surname>Griffiths</surname><given-names>T. D.</given-names></name> <etal/></person-group>. (<year>2016</year>). <article-title>Hearing and dementia</article-title>. <source>J. Neurol.</source> <volume>263</volume>, <fpage>2339</fpage>&#x2013;<lpage>2354</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s00415-016-8208-y</pub-id>, <pub-id pub-id-type="pmid">27372450</pub-id></mixed-citation></ref>
<ref id="ref50"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heffernan</surname><given-names>E.</given-names></name> <name><surname>Calvert</surname><given-names>S.</given-names></name> <name><surname>Dening</surname><given-names>T.</given-names></name> <name><surname>Broome</surname><given-names>E. E.</given-names></name> <name><surname>Spriggs</surname><given-names>R.</given-names></name> <name><surname>Ahmad</surname><given-names>N.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>James Lind Alliance priority setting partnership in co-existing dementia and hearing conditions: a research agenda defined by people with lived experience and healthcare professionals</article-title>. <source>Age Ageing</source> <volume>54</volume>:<fpage>afaf191</fpage>. doi: <pub-id pub-id-type="doi">10.1093/ageing/afaf191</pub-id>, <pub-id pub-id-type="pmid">40618343</pub-id></mixed-citation></ref>
<ref id="ref51"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Homans</surname><given-names>N. C.</given-names></name> <name><surname>Metselaar</surname><given-names>R. M.</given-names></name> <name><surname>Dingemanse</surname><given-names>J. G.</given-names></name> <name><surname>van der Schroeff</surname><given-names>M.</given-names></name> <name><surname>Brocaar</surname><given-names>M. P.</given-names></name> <name><surname>Wieringa</surname><given-names>M. H.</given-names></name> <etal/></person-group>. (<year>2017</year>). <article-title>Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study</article-title>. <source>Laryngoscope</source> <volume>127</volume>, <fpage>725</fpage>&#x2013;<lpage>730</lpage>. doi: <pub-id pub-id-type="doi">10.1002/lary.26150</pub-id>, <pub-id pub-id-type="pmid">27377351</pub-id></mixed-citation></ref>
<ref id="ref52"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>A. R.</given-names></name> <name><surname>Jiang</surname><given-names>K.</given-names></name> <name><surname>Lin</surname><given-names>F. R.</given-names></name> <name><surname>Deal</surname><given-names>J. A.</given-names></name> <name><surname>Reed</surname><given-names>N. S.</given-names></name></person-group> (<year>2023</year>). <article-title>Hearing loss and dementia prevalence in older adults in the US</article-title>. <source>JAMA</source> <volume>329</volume>, <fpage>171</fpage>&#x2013;<lpage>173</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jama.2022.20954</pub-id>, <pub-id pub-id-type="pmid">36625819</pub-id></mixed-citation></ref>
<ref id="ref53"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>A. R.</given-names></name> <name><surname>Lin</surname><given-names>F. R.</given-names></name></person-group> (<year>2024</year>). <article-title>Hearing loss and dementia in older adults: a narrative review</article-title>. <source>J. Chin. Med. Assoc.</source> <volume>87</volume>, <fpage>252</fpage>&#x2013;<lpage>258</lpage>. doi: <pub-id pub-id-type="doi">10.1097/JCMA.0000000000001042</pub-id>, <pub-id pub-id-type="pmid">38112446</pub-id></mixed-citation></ref>
<ref id="ref54"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ishak</surname><given-names>E.</given-names></name> <name><surname>Burg</surname><given-names>E. A.</given-names></name> <name><surname>Pike</surname><given-names>J. R.</given-names></name> <name><surname>Amezcua</surname><given-names>P. M.</given-names></name> <name><surname>Jiang</surname><given-names>K.</given-names></name> <name><surname>Powell</surname><given-names>D. S.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>Population attributable fraction of incident dementia associated with hearing loss</article-title>. <source>JAMA Otolaryngol. Head Neck Surg.</source> <volume>151</volume>, <fpage>568</fpage>&#x2013;<lpage>575</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jamaoto.2025.0192</pub-id>, <pub-id pub-id-type="pmid">40244612</pub-id></mixed-citation></ref>
<ref id="ref55"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Johnson</surname><given-names>J. C.</given-names></name></person-group> (<year>2021</year>). <article-title>Hearing and dementia: from ears to brain</article-title>. <source>Brain</source> <volume>144</volume>, <fpage>391</fpage>&#x2013;<lpage>401</lpage>. doi: <pub-id pub-id-type="doi">10.1093/brain/awaa429</pub-id></mixed-citation></ref>
<ref id="ref56"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Karawani</surname><given-names>H.</given-names></name> <name><surname>Jenkins</surname><given-names>K.</given-names></name> <name><surname>Anderson</surname><given-names>S.</given-names></name></person-group> (<year>2018</year>). <article-title>Restoration of sensory input may improve cognitive and neural function</article-title>. <source>Neuropsychologia</source> <volume>114</volume>, <fpage>203</fpage>&#x2013;<lpage>213</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.neuropsychologia.2018.04.041</pub-id>, <pub-id pub-id-type="pmid">29729278</pub-id></mixed-citation></ref>
<ref id="ref57"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>J. S.</given-names></name></person-group> (<year>2020</year>). <article-title>Conductive hearing loss aggravates memory decline in Alzheimer model mice</article-title>. <source>Front. Neurosci.</source> <volume>14</volume>:<fpage>843</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fnins.2020.00843</pub-id></mixed-citation></ref>
<ref id="ref58"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kurniawan</surname><given-names>C.</given-names></name> <name><surname>Westendorp</surname><given-names>R. G.</given-names></name> <name><surname>de Craen</surname><given-names>A. J.</given-names></name> <name><surname>Gussekloo</surname><given-names>J.</given-names></name> <name><surname>de Laat</surname><given-names>J.</given-names></name> <name><surname>van Exel</surname><given-names>E.</given-names></name></person-group> (<year>2012</year>). <article-title>Gene dose of apolipoprotein E and age-related hearing loss</article-title>. <source>Neurobiol. Aging</source> <volume>33</volume>, <fpage>2230.e7</fpage>&#x2013;<lpage>2230.e12</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2012.04.001</pub-id>, <pub-id pub-id-type="pmid">22542837</pub-id></mixed-citation></ref>
<ref id="ref59"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lasica</surname><given-names>A. B.</given-names></name> <name><surname>Sheppard</surname><given-names>J.</given-names></name> <name><surname>Yu</surname><given-names>R.-C.</given-names></name> <name><surname>Livingston</surname><given-names>G.</given-names></name> <name><surname>Ridgway</surname><given-names>N.</given-names></name> <name><surname>Omar</surname><given-names>R.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>Association between adult-onset hearing loss and dementia biomarkers: a systematic review</article-title>. <source>Ageing Res. Rev.</source> <volume>104</volume>:<fpage>102647</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.arr.2024.102647</pub-id>, <pub-id pub-id-type="pmid">39746404</pub-id></mixed-citation></ref>
<ref id="ref60"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Levett</surname><given-names>B. A.</given-names></name> <name><surname>Chandra</surname><given-names>A.</given-names></name> <name><surname>Jiang</surname><given-names>J.</given-names></name> <name><surname>Koohi</surname><given-names>N.</given-names></name> <name><surname>Sharrad</surname><given-names>D.</given-names></name> <name><surname>Core</surname><given-names>L. B.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>Hearing impairment and dementia: cause, catalyst or consequence?</article-title> <source>J. Neurol.</source> <volume>272</volume>:<fpage>402</fpage>. doi: <pub-id pub-id-type="doi">10.1007/s00415-025-13140-x</pub-id>, <pub-id pub-id-type="pmid">40377748</pub-id></mixed-citation></ref>
<ref id="ref61"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lewis</surname><given-names>D. A.</given-names></name> <name><surname>Campbell</surname><given-names>M. J.</given-names></name> <name><surname>Terry</surname><given-names>R. D.</given-names></name> <name><surname>Morrison</surname><given-names>J. H.</given-names></name></person-group> (<year>1987</year>). <article-title>Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices</article-title>. <source>J. Neurosci.</source> <volume>7</volume>, <fpage>1799</fpage>&#x2013;<lpage>1808</lpage>.</mixed-citation></ref>
<ref id="ref62"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>F. R.</given-names></name></person-group> (<year>2023</year>). <article-title>Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial</article-title>. <source>Lancet</source> <volume>402</volume>, <fpage>786</fpage>&#x2013;<lpage>797</lpage>. doi: <pub-id pub-id-type="doi">10.1016/s0140-6736(23)01406-x</pub-id></mixed-citation></ref>
<ref id="ref63"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>F. R.</given-names></name> <name><surname>Albert</surname><given-names>M.</given-names></name></person-group> (<year>2014</year>). &#x201C;Hearing Loss and Dementia &#x2013; Who Is Listening?&#x201D; <source>Aging &#x0026; Mental Health</source> <volume>18</volume>, <fpage>671</fpage>&#x2013;<lpage>673</lpage>. doi: <pub-id pub-id-type="doi">10.1080/13607863.2014.915924</pub-id></mixed-citation></ref>
<ref id="ref64"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>F.</given-names></name> <name><surname>Lin</surname><given-names>F. R.</given-names></name> <name><surname>Ferrucci</surname><given-names>L.</given-names></name> <name><surname>An</surname><given-names>Y.</given-names></name> <name><surname>Goh</surname><given-names>J. O.</given-names></name> <name><surname>Doshi</surname><given-names>J.</given-names></name> <etal/></person-group>. (<year>2014</year>). <article-title>Association of hearing impairment with brain volume changes in older adults</article-title>. <source>NeuroImage</source> <volume>90</volume>, <fpage>84</fpage>&#x2013;<lpage>92</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.neuroimage.2013.12.059</pub-id>, <pub-id pub-id-type="pmid">24412398</pub-id></mixed-citation></ref>
<ref id="ref65"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>F. R.</given-names></name> <name><surname>Metter</surname><given-names>E. J.</given-names></name> <name><surname>O'Brien</surname><given-names>R. J.</given-names></name> <name><surname>Resnick</surname><given-names>S. M.</given-names></name> <name><surname>Zonderman</surname><given-names>A. B.</given-names></name> <name><surname>Ferrucci</surname><given-names>L.</given-names></name></person-group> (<year>2011</year>). <article-title>Hearing loss and incident dementia</article-title>. <source>Arch. Neurol.</source> <volume>68</volume>, <fpage>214</fpage>&#x2013;<lpage>220</lpage>. doi: <pub-id pub-id-type="doi">10.1001/archneurol.2010.362</pub-id>, <pub-id pub-id-type="pmid">21320988</pub-id></mixed-citation></ref>
<ref id="ref66"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Littlejohn</surname><given-names>J.</given-names></name> <name><surname>Bowen</surname><given-names>M.</given-names></name> <name><surname>Constantinidou</surname><given-names>F.</given-names></name> <name><surname>Dawes</surname><given-names>P.</given-names></name> <name><surname>Dickinson</surname><given-names>C.</given-names></name> <name><surname>Heyn</surname><given-names>P.</given-names></name> <etal/></person-group>. (<year>2022</year>). <article-title>International practice recommendations for the recognition and management of hearing and vision impairment in people with dementia</article-title>. <source>Gerontology</source> <volume>68</volume>, <fpage>121</fpage>&#x2013;<lpage>135</lpage>. doi: <pub-id pub-id-type="doi">10.1159/000515892</pub-id>, <pub-id pub-id-type="pmid">34091448</pub-id></mixed-citation></ref>
<ref id="ref67"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname><given-names>Y.</given-names></name> <name><surname>Fang</surname><given-names>S.</given-names></name> <name><surname>Liu</surname><given-names>L.-M.</given-names></name> <name><surname>Zhu</surname><given-names>Y.</given-names></name> <name><surname>Li</surname><given-names>C.-R.</given-names></name> <name><surname>Chen</surname><given-names>K.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Hearing loss is an early biomarker in APP/PS1 Alzheimer's disease mice</article-title>. <source>Neurosci. Lett.</source> <volume>717</volume>:<fpage>134705</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.neulet.2019.134705</pub-id>, <pub-id pub-id-type="pmid">31870800</pub-id></mixed-citation></ref>
<ref id="ref68"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Livingston</surname><given-names>G.</given-names></name> <name><surname>Huntley</surname><given-names>J.</given-names></name> <name><surname>Liu</surname><given-names>K. Y.</given-names></name> <name><surname>Costafreda</surname><given-names>S. G.</given-names></name> <name><surname>Selb&#x00E6;k</surname><given-names>G.</given-names></name> <name><surname>Alladi</surname><given-names>S.</given-names></name> <etal/></person-group>. (<year>2024</year>). <article-title>Dementia prevention, intervention, and care: 2024 report of the lancet standing commission</article-title>. <source>Lancet</source> <volume>404</volume>, <fpage>572</fpage>&#x2013;<lpage>628</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0140-6736(24)01296-0</pub-id>, <pub-id pub-id-type="pmid">39096926</pub-id></mixed-citation></ref>
<ref id="ref69"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Livingston</surname><given-names>G.</given-names></name> <name><surname>Huntley</surname><given-names>J.</given-names></name> <name><surname>Sommerlad</surname><given-names>A.</given-names></name> <name><surname>Ames</surname><given-names>D.</given-names></name> <name><surname>Ballard</surname><given-names>C.</given-names></name> <name><surname>Banerjee</surname><given-names>S.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Dementia prevention, intervention, and care: 2020 report of the lancet commission</article-title>. <source>Lancet</source> <volume>396</volume>, <fpage>413</fpage>&#x2013;<lpage>446</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0140-6736(20)30367-6</pub-id>, <pub-id pub-id-type="pmid">32738937</pub-id></mixed-citation></ref>
<ref id="ref70"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Livingston</surname><given-names>G.</given-names></name> <name><surname>Sommerlad</surname><given-names>A.</given-names></name> <name><surname>Orgeta</surname><given-names>V.</given-names></name> <name><surname>Costafreda</surname><given-names>S. G.</given-names></name> <name><surname>Huntley</surname><given-names>J.</given-names></name> <name><surname>Ames</surname><given-names>D.</given-names></name> <etal/></person-group>. (<year>2017</year>). <article-title>Dementia prevention, intervention, and care</article-title>. <source>Lancet</source> <volume>390</volume>, <fpage>2673</fpage>&#x2013;<lpage>2734</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0140-6736(17)31363-6</pub-id>, <pub-id pub-id-type="pmid">28735855</pub-id></mixed-citation></ref>
<ref id="ref71"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Loughrey</surname><given-names>D. G.</given-names></name> <name><surname>Kelly</surname><given-names>M. E.</given-names></name> <name><surname>Kelley</surname><given-names>G. A.</given-names></name> <name><surname>Brennan</surname><given-names>S.</given-names></name> <name><surname>Lawlor</surname><given-names>B. A.</given-names></name></person-group> (<year>2018</year>). <article-title>Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis</article-title>. <source>JAMA Otolaryngol. Head Neck Surg.</source> <volume>144</volume>, <fpage>115</fpage>&#x2013;<lpage>126</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jamaoto.2017.2513</pub-id>, <pub-id pub-id-type="pmid">29222544</pub-id></mixed-citation></ref>
<ref id="ref72"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Machado</surname><given-names>M. G.</given-names></name> <name><surname>Machado</surname><given-names>T. H.</given-names></name> <name><surname>Caramelli</surname><given-names>P.</given-names></name> <name><surname>Gon&#x00E7;alves Tosatti</surname><given-names>J. A.</given-names></name> <name><surname>da Silva Carvalho</surname><given-names>S. A.</given-names></name> <name><surname>de Resen</surname><given-names>L. M.</given-names></name></person-group> (<year>2024</year>). <article-title>Effects of hearing aid use on individuals diagnosed with hearing loss and dementia: a systematic review</article-title>. <source>J Alzheimer's Dis</source> <volume>100</volume>, <fpage>1133</fpage>&#x2013;<lpage>1143</lpage>. doi: <pub-id pub-id-type="doi">10.3233/jad-231460</pub-id>, <pub-id pub-id-type="pmid">38995779</pub-id></mixed-citation></ref>
<ref id="ref73"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Maharani</surname><given-names>A.</given-names></name> <name><surname>Dawes</surname><given-names>P.</given-names></name> <name><surname>Nazroo</surname><given-names>J.</given-names></name> <name><surname>Tampubolon</surname><given-names>G.</given-names></name> <name><surname>Pendleton</surname><given-names>N.</given-names></name></person-group> (<year>2018</year>). <article-title>Longitudinal relationship between hearing aid use and cognitive function in older Americans</article-title>. <source>J. Am. Geriatr. Soc.</source> <volume>66</volume>, <fpage>1130</fpage>&#x2013;<lpage>1136</lpage>. doi: <pub-id pub-id-type="doi">10.1111/jgs.15363</pub-id>, <pub-id pub-id-type="pmid">29637544</pub-id></mixed-citation></ref>
<ref id="ref74"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mahmoudi</surname><given-names>E.</given-names></name> <name><surname>Basu</surname><given-names>T.</given-names></name> <name><surname>Langa</surname><given-names>K.</given-names></name> <name><surname>McKee</surname><given-names>M. M.</given-names></name> <name><surname>Zazove</surname><given-names>P.</given-names></name> <name><surname>Alexander</surname><given-names>N.</given-names></name> <etal/></person-group>. (<year>2019</year>). <article-title>Can hearing aids delay time to diagnosis of dementia, depression, or falls in older adults?</article-title> <source>J. Am. Geriatr. Soc.</source> <volume>67</volume>, <fpage>2362</fpage>&#x2013;<lpage>2369</lpage>. doi: <pub-id pub-id-type="doi">10.1111/jgs.16109</pub-id>, <pub-id pub-id-type="pmid">31486068</pub-id></mixed-citation></ref>
<ref id="ref75"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mamo</surname><given-names>S. K.</given-names></name></person-group> (<year>2018</year>). <article-title>Hearing loss treatment in older adults with cognitive impairment: a systematic review</article-title>. <source>J. Speech Lang. Hear. Res.</source> <volume>61</volume>, <fpage>2589</fpage>&#x2013;<lpage>2603</lpage>. doi: <pub-id pub-id-type="doi">10.1044/2018_jslhr-h-18-0077</pub-id></mixed-citation></ref>
<ref id="ref76"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mamo</surname><given-names>S. K.</given-names></name> <name><surname>Nirmalasari</surname><given-names>O.</given-names></name> <name><surname>Nieman</surname><given-names>C. L.</given-names></name> <name><surname>McNabney</surname><given-names>M.</given-names></name> <name><surname>Simpson</surname><given-names>A.</given-names></name> <name><surname>Oh</surname><given-names>E. S.</given-names></name> <etal/></person-group>. (<year>2017</year>). <article-title>Hearing care intervention for persons with dementia: a pilot study</article-title>. <source>Am. J. Geriatr. Psychiatry</source> <volume>25</volume>, <fpage>91</fpage>&#x2013;<lpage>101</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jagp.2016.08.019</pub-id>, <pub-id pub-id-type="pmid">27890543</pub-id></mixed-citation></ref>
<ref id="ref77"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mansournia</surname><given-names>M. A.</given-names></name> <name><surname>Altman</surname><given-names>D. G.</given-names></name></person-group> (<year>2018</year>). <article-title>Population attributable fraction</article-title>. <source>BMJ</source> <volume>360</volume>:<fpage>k757</fpage>. doi: <pub-id pub-id-type="doi">10.1136/bmj.k757</pub-id></mixed-citation></ref>
<ref id="ref78"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marinelli</surname><given-names>J. P.</given-names></name> <name><surname>Lohse</surname><given-names>C. M.</given-names></name> <name><surname>Fussell</surname><given-names>W. L.</given-names></name> <name><surname>Petersen</surname><given-names>R. C.</given-names></name> <name><surname>Reed</surname><given-names>N. S.</given-names></name> <name><surname>Machulda</surname><given-names>M. M.</given-names></name> <etal/></person-group>. (<year>2022</year>). <article-title>Association between hearing loss and development of dementia using formal behavioural audiometric testing within the Mayo Clinic study of aging (MCSA): a prospective population-based study</article-title>. <source>Lancet Healthy Longev</source> <volume>3</volume>, <fpage>e817</fpage>&#x2013;<lpage>e824</lpage>. doi: <pub-id pub-id-type="doi">10.1016/s2666-7568(22)00241-0</pub-id></mixed-citation></ref>
<ref id="ref79"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mohammed</surname><given-names>A.</given-names></name> <name><surname>Gibbons</surname><given-names>L. E.</given-names></name> <name><surname>Gates</surname><given-names>G.</given-names></name> <name><surname>Anderson</surname><given-names>M. L.</given-names></name> <name><surname>McCurry</surname><given-names>S. M.</given-names></name> <name><surname>McCormick</surname><given-names>W.</given-names></name> <etal/></person-group>. (<year>2022</year>). <article-title>Association of performance on dichotic auditory tests with risk for incident dementia and Alzheimer dementia</article-title>. <source>JAMA Otolaryngol. Head Neck Surg.</source> <volume>148</volume>, <fpage>20</fpage>&#x2013;<lpage>27</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jamaoto.2021.2716</pub-id>, <pub-id pub-id-type="pmid">34647974</pub-id></mixed-citation></ref>
<ref id="ref80"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mosnier</surname><given-names>I.</given-names></name> <name><surname>Vanier</surname><given-names>A.</given-names></name> <name><surname>Bonnard</surname><given-names>D.</given-names></name> <name><surname>Lina-Granade</surname><given-names>G.</given-names></name> <name><surname>Truy</surname><given-names>E.</given-names></name> <name><surname>Bordure</surname><given-names>P.</given-names></name> <etal/></person-group>. (<year>2018</year>). <article-title>Long-term cognitive prognosis of profoundly deaf older adults after hearing rehabilitation using cochlear implants</article-title>. <source>J. Am. Geriatr. Soc.</source> <volume>66</volume>, <fpage>1553</fpage>&#x2013;<lpage>1561</lpage>. doi: <pub-id pub-id-type="doi">10.1111/jgs.15445</pub-id>, <pub-id pub-id-type="pmid">30091185</pub-id></mixed-citation></ref>
<ref id="ref81"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Na</surname><given-names>D.</given-names></name></person-group> (<year>2023</year>). <article-title>Neuroinflammation in a mouse model of Alzheimer's disease versus auditory dysfunction: machine learning interpretation and analysis</article-title>. <source>Res. Sq.</source> doi: <pub-id pub-id-type="doi">10.21203/rs.3.rs-3370200/v1</pub-id></mixed-citation></ref>
<ref id="ref82"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll3">National Institute for Health and Care Excellence</collab></person-group> <source>Hearing loss in adults: Assessment and management</source>. London, UK, National Institute for Health and Care Excellence. (<year>2018a</year>).</mixed-citation></ref>
<ref id="ref83"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll4">National Institute for Health and Care Excellence</collab></person-group> <source>Dementia: Assessment, management and support for people living with dementia and their carers</source>. London, UK, National Institute for Health and Care Excellence. (<year>2018b</year>).</mixed-citation></ref>
<ref id="ref84"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Naylor</surname><given-names>G.</given-names></name> <name><surname>Dillard</surname><given-names>L.</given-names></name> <name><surname>Orrell</surname><given-names>M.</given-names></name> <name><surname>Stephan</surname><given-names>B. C. M.</given-names></name> <name><surname>Zobay</surname><given-names>O.</given-names></name> <name><surname>Saunders</surname><given-names>G. H.</given-names></name></person-group> (<year>2022</year>). <article-title>Dementia and hearing-aid use: a two-way street</article-title>. <source>Age Ageing</source> <volume>51</volume>:<fpage>afac266</fpage>. doi: <pub-id pub-id-type="doi">10.1093/ageing/afac266</pub-id>, <pub-id pub-id-type="pmid">36571777</pub-id></mixed-citation></ref>
<ref id="ref85"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Newall</surname><given-names>J.</given-names></name></person-group> (<year>2025</year>). <article-title>Hearing loss configurations in low-and middle-income countries</article-title>. <source>Int. J. Audiol.</source> <volume>64</volume>, <fpage>1027</fpage>&#x2013;<lpage>1034</lpage>. doi: <pub-id pub-id-type="doi">10.1080/14992027.2025.2466746</pub-id></mixed-citation></ref>
<ref id="ref86"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nguyen</surname><given-names>M.-F.</given-names></name> <name><surname>Bonnefoy</surname><given-names>M.</given-names></name> <name><surname>Adrait</surname><given-names>A.</given-names></name> <name><surname>Gueugnon</surname><given-names>M.</given-names></name> <name><surname>Petitot</surname><given-names>C.</given-names></name> <name><surname>Collet</surname><given-names>L.</given-names></name> <etal/></person-group>. (<year>2017</year>). <article-title>Efficacy of hearing aids on the cognitive status of patients with Alzheimer&#x2019;s disease and hearing loss: a multicenter controlled randomized trial</article-title>. <source>J Alzheimer's Dis</source> <volume>58</volume>, <fpage>123</fpage>&#x2013;<lpage>137</lpage>. doi: <pub-id pub-id-type="doi">10.3233/JAD-160793</pub-id>, <pub-id pub-id-type="pmid">28387664</pub-id></mixed-citation></ref>
<ref id="ref87"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll5">NIHR</collab></person-group> <source>Improving inclusion of under-served groups in clinical research: Guidance from INCLUDE project</source>. United Kingdom, National Institute for Health and Care Research (NIHR). (<year>2022</year>).</mixed-citation></ref>
<ref id="ref88"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nishiyama</surname><given-names>T.</given-names></name> <name><surname>Kimizuka</surname><given-names>T.</given-names></name> <name><surname>Kataoka</surname><given-names>C.</given-names></name> <name><surname>Tazoe</surname><given-names>M.</given-names></name> <name><surname>Sato</surname><given-names>Y.</given-names></name> <name><surname>Hosoya</surname><given-names>M.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>Relationship between hearing thresholds and cognitive function in hearing aid non-users and long-term users post-midlife</article-title>. <source>NPJ Aging</source> <volume>11</volume>:<fpage>14</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s41514-025-00203-6</pub-id>, <pub-id pub-id-type="pmid">39994290</pub-id></mixed-citation></ref>
<ref id="ref89"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nkyekyer</surname><given-names>J.</given-names></name> <name><surname>Meyer</surname><given-names>D.</given-names></name> <name><surname>Pipingas</surname><given-names>A.</given-names></name> <name><surname>Reed</surname><given-names>N. S.</given-names></name></person-group> (<year>2019</year>). <article-title>The cognitive and psychosocial effects of auditory training and hearing aids in adults with hearing loss</article-title>. <source>Clin. Interv. Aging</source> <volume>14</volume>, <fpage>123</fpage>&#x2013;<lpage>135</lpage>. doi: <pub-id pub-id-type="doi">10.2147/CIA.S183905</pub-id>, <pub-id pub-id-type="pmid">30666098</pub-id></mixed-citation></ref>
<ref id="ref90"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ohlenforst</surname><given-names>B.</given-names></name> <name><surname>Zekveld</surname><given-names>A. A.</given-names></name> <name><surname>Lunner</surname><given-names>T.</given-names></name> <name><surname>Wendt</surname><given-names>D.</given-names></name> <name><surname>Naylor</surname><given-names>G.</given-names></name> <name><surname>Wang</surname><given-names>Y.</given-names></name> <etal/></person-group>. (<year>2017</year>). <article-title>Impact of stimulus-related factors and hearing impairment on listening effort as indicated by pupil dilation</article-title>. <source>Hear. Res.</source> <volume>351</volume>, <fpage>68</fpage>&#x2013;<lpage>79</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.heares.2017.05.012</pub-id>, <pub-id pub-id-type="pmid">28622894</pub-id></mixed-citation></ref>
<ref id="ref91"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Okano</surname><given-names>T.</given-names></name> <name><surname>Yamamoto</surname><given-names>Y.</given-names></name> <name><surname>Kuzuya</surname><given-names>A.</given-names></name> <name><surname>Egawa</surname><given-names>N.</given-names></name> <name><surname>Furuta</surname><given-names>I.</given-names></name> <name><surname>Mizuno</surname><given-names>K.</given-names></name> <etal/></person-group>. (<year>2024</year>). <article-title>Interactive effects of hearing aid use and cognitive function in patients with hearing loss</article-title>. <source>Psychogeriatrics</source> <volume>24</volume>, <fpage>655</fpage>&#x2013;<lpage>664</lpage>. doi: <pub-id pub-id-type="doi">10.1111/psyg.13119</pub-id>, <pub-id pub-id-type="pmid">38528710</pub-id></mixed-citation></ref>
<ref id="ref92"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Osler</surname><given-names>M.</given-names></name> <name><surname>Christensen</surname><given-names>G. T.</given-names></name> <name><surname>Mortensen</surname><given-names>E. L.</given-names></name> <name><surname>Christensen</surname><given-names>K.</given-names></name> <name><surname>Garde</surname><given-names>E.</given-names></name> <name><surname>Rozing</surname><given-names>M. P.</given-names></name></person-group> (<year>2019</year>). <article-title>Hearing loss, cognitive ability, and dementia in men age 19&#x2013;78 years</article-title>. <source>Eur. J. Epidemiol.</source> <volume>34</volume>, <fpage>125</fpage>&#x2013;<lpage>130</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s10654-018-0452-2</pub-id>, <pub-id pub-id-type="pmid">30306425</pub-id></mixed-citation></ref>
<ref id="ref93"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paciello</surname><given-names>F.</given-names></name></person-group> (<year>2021</year>). <article-title>Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer's disease</article-title>. <source>eLife</source> <volume>10</volume>, <fpage>1</fpage>&#x2013;<lpage>28</lpage>. doi: <pub-id pub-id-type="doi">10.7554/elife.70908</pub-id></mixed-citation></ref>
<ref id="ref94"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Panza</surname><given-names>F.</given-names></name> <name><surname>Solfrizzi</surname><given-names>V.</given-names></name> <name><surname>Logroscino</surname><given-names>G.</given-names></name></person-group> (<year>2015</year>). <article-title>Age-related hearing impairment&#x2014;a risk factor and frailty marker for dementia and AD</article-title>. <source>Nat. Rev. Neurol.</source> <volume>11</volume>, <fpage>166</fpage>&#x2013;<lpage>175</lpage>. doi: <pub-id pub-id-type="doi">10.1038/nrneurol.2015.12</pub-id></mixed-citation></ref>
<ref id="ref95"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paradela</surname><given-names>R. S.</given-names></name> <name><surname>Calandri</surname><given-names>I.</given-names></name> <name><surname>Castro</surname><given-names>N. P.</given-names></name> <name><surname>Garat</surname><given-names>E.</given-names></name> <name><surname>Delgado</surname><given-names>C.</given-names></name> <name><surname>Crivelli</surname><given-names>L.</given-names></name> <etal/></person-group>. (<year>2024</year>). <article-title>Population attributable fractions for risk factors for dementia in seven Latin American countries: an analysis using cross-sectional survey data</article-title>. <source>Lancet Glob. Health</source> <volume>12</volume>, <fpage>e1600</fpage>&#x2013;<lpage>e1610</lpage>. doi: <pub-id pub-id-type="doi">10.1016/s2214-109x(24)00275-4</pub-id>, <pub-id pub-id-type="pmid">39304234</pub-id></mixed-citation></ref>
<ref id="ref96"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Park</surname><given-names>J. H.</given-names></name> <name><surname>Bohr</surname><given-names>V. A.</given-names></name> <name><surname>Sahbaz</surname><given-names>B. D.</given-names></name> <name><surname>Pekhale</surname><given-names>K.</given-names></name> <name><surname>Chu</surname><given-names>X.</given-names></name> <name><surname>Okur</surname><given-names>M. N.</given-names></name> <etal/></person-group>. (<year>2024</year>). <article-title>Early-onset hearing loss in mouse models of Alzheimer's disease and increased DNA damage in the cochlea</article-title>. <source>Aging Biology</source> <volume>1</volume>, <fpage>1</fpage>&#x2013;<lpage>16</lpage>. doi: <pub-id pub-id-type="doi">10.59368/agingbio.20240025</pub-id>, <pub-id pub-id-type="pmid">38500536</pub-id></mixed-citation></ref>
<ref id="ref97"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Parmar</surname><given-names>B.</given-names></name> <name><surname>Henshaw</surname><given-names>H.</given-names></name> <name><surname>Howe</surname><given-names>S.</given-names></name> <name><surname>Dickinson</surname><given-names>A. M.</given-names></name> <name><surname>Rolfe</surname><given-names>C.</given-names></name> <name><surname>Le Mere</surname><given-names>P.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>"I always feel like i'm the first deaf person they have ever met:" deaf awareness, accessibility and communication in the United Kingdom's National Health Service (NHS): how can we do better?</article-title> <source>PLoS One</source> <volume>20</volume>:<fpage>e0322850</fpage>. doi: <pub-id pub-id-type="doi">10.1371/journal.pone.0322850</pub-id>, <pub-id pub-id-type="pmid">40333900</pub-id></mixed-citation></ref>
<ref id="ref98"><mixed-citation publication-type="other"><person-group person-group-type="author"><name><surname>Patterson</surname><given-names>C.</given-names></name></person-group>, <source>The world Alzheimer report</source>. London, UK, Alzheimer&#x2019;s Disease International (ADI). (<year>2018</year>).</mixed-citation></ref>
<ref id="ref99"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Penninkilampi</surname><given-names>R.</given-names></name> <name><surname>Casey</surname><given-names>A. N.</given-names></name> <name><surname>Singh</surname><given-names>M. F.</given-names></name> <name><surname>Brodaty</surname><given-names>H.</given-names></name></person-group> (<year>2018</year>). <article-title>The association between social engagement, loneliness, and risk of dementia: a systematic review and meta-analysis</article-title>. <source>J Alzheimer's Dis</source> <volume>66</volume>, <fpage>1619</fpage>&#x2013;<lpage>1633</lpage>. doi: <pub-id pub-id-type="doi">10.3233/JAD-180439</pub-id>, <pub-id pub-id-type="pmid">30452410</pub-id></mixed-citation></ref>
<ref id="ref100"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pichora-Fuller</surname><given-names>M. K.</given-names></name></person-group> (<year>2003</year>). <article-title>Cognitive aging and auditory information processing</article-title>. <source>Int. J. Audiol.</source> <volume>42</volume>, <fpage>S26</fpage>&#x2013;<lpage>S32</lpage>.</mixed-citation></ref>
<ref id="ref101"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pichora-Fuller</surname><given-names>M. K.</given-names></name> <name><surname>Kramer</surname><given-names>S. E.</given-names></name> <name><surname>Eckert</surname><given-names>M. A.</given-names></name> <name><surname>Edwards</surname><given-names>B.</given-names></name> <name><surname>Hornsby</surname><given-names>B. W. Y.</given-names></name> <name><surname>Humes</surname><given-names>L. E.</given-names></name> <etal/></person-group>. (<year>2016</year>). <article-title>Hearing impairment and cognitive energy: the framework for understanding effortful listening (FUEL)</article-title>. <source>Ear Hear.</source> <volume>37</volume>, <fpage>5S</fpage>&#x2013;<lpage>27S</lpage>. doi: <pub-id pub-id-type="doi">10.1097/aud.0000000000000312</pub-id>, <pub-id pub-id-type="pmid">27355771</pub-id></mixed-citation></ref>
<ref id="ref102"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ponticorvo</surname><given-names>S.</given-names></name> <name><surname>Manara</surname><given-names>R.</given-names></name> <name><surname>Pfeuffer</surname><given-names>J.</given-names></name> <name><surname>Cappiello</surname><given-names>A.</given-names></name> <name><surname>Cuoco</surname><given-names>S.</given-names></name> <name><surname>Pellecchia</surname><given-names>M. T.</given-names></name> <etal/></person-group>. (<year>2019</year>). <article-title>Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI</article-title>. <source>Hum. Brain Mapp.</source> <volume>40</volume>, <fpage>2475</fpage>&#x2013;<lpage>2487</lpage>. doi: <pub-id pub-id-type="doi">10.1002/hbm.24538</pub-id>, <pub-id pub-id-type="pmid">30715769</pub-id></mixed-citation></ref>
<ref id="ref103"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Powell</surname><given-names>D. S.</given-names></name> <name><surname>Brenowitz</surname><given-names>W. D.</given-names></name> <name><surname>Yaffe</surname><given-names>K.</given-names></name> <name><surname>Armstrong</surname><given-names>N. M.</given-names></name> <name><surname>Reed</surname><given-names>N. S.</given-names></name> <name><surname>Lin</surname><given-names>F. R.</given-names></name> <etal/></person-group>. (<year>2022</year>). <article-title>Examining the combined estimated effects of hearing loss and depressive symptoms on risk of cognitive decline and incident dementia</article-title>. <source>J. Gerontol. Ser. B</source> <volume>77</volume>, <fpage>839</fpage>&#x2013;<lpage>849</lpage>. doi: <pub-id pub-id-type="doi">10.1093/geronb/gbab194</pub-id>, <pub-id pub-id-type="pmid">34655295</pub-id></mixed-citation></ref>
<ref id="ref104"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Prince</surname><given-names>M.</given-names></name></person-group> (<year>2014</year>). <source>Dementia UK: Second edition - overview</source>. London, UK: <publisher-name>Alzheimer's Society</publisher-name>.</mixed-citation></ref>
<ref id="ref105"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pryce</surname><given-names>H.</given-names></name> <name><surname>Gooberman-Hill</surname><given-names>R.</given-names></name></person-group> (<year>2012</year>). <article-title>There's a hell of a noise': living with a hearing loss in residential care</article-title>. <source>Age Ageing</source> <volume>41</volume>, <fpage>40</fpage>&#x2013;<lpage>46</lpage>. doi: <pub-id pub-id-type="doi">10.1093/ageing/afr112</pub-id></mixed-citation></ref>
<ref id="ref106"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pye</surname><given-names>A.</given-names></name> <name><surname>Charalambous</surname><given-names>A. P.</given-names></name> <name><surname>Leroi</surname><given-names>I.</given-names></name> <name><surname>Thodi</surname><given-names>C.</given-names></name> <name><surname>Dawes</surname><given-names>P.</given-names></name></person-group> (<year>2017</year>). <article-title>Screening tools for the identification of dementia for adults with age-related acquired hearing or vision impairment: a scoping review</article-title>. <source>Int. Psychogeriatr.</source> <volume>29</volume>, <fpage>1771</fpage>&#x2013;<lpage>1784</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S104161021700120X</pub-id>, <pub-id pub-id-type="pmid">28691649</pub-id></mixed-citation></ref>
<ref id="ref107"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Qian</surname><given-names>Z. J.</given-names></name> <name><surname>Wattamwar</surname><given-names>K.</given-names></name> <name><surname>Caruana</surname><given-names>F. F.</given-names></name> <name><surname>Otter</surname><given-names>J.</given-names></name> <name><surname>Leskowitz</surname><given-names>M. J.</given-names></name> <name><surname>Siedlecki</surname><given-names>B.</given-names></name> <etal/></person-group>. (<year>2016</year>). <article-title>Hearing aid use is associated with better Mini-mental state exam performance</article-title>. <source>Am. J. Geriatr. Psychiatry</source> <volume>24</volume>, <fpage>694</fpage>&#x2013;<lpage>702</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jagp.2016.03.005</pub-id>, <pub-id pub-id-type="pmid">27394684</pub-id></mixed-citation></ref>
<ref id="ref108"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ralli</surname><given-names>M.</given-names></name> <name><surname>Gilardi</surname><given-names>A.</given-names></name> <name><surname>Stadio</surname><given-names>A. D.</given-names></name> <name><surname>Severini</surname><given-names>C.</given-names></name> <name><surname>Greco</surname><given-names>A.</given-names></name> <name><surname>Vincentiis</surname><given-names>M. d.</given-names></name> <etal/></person-group>. (<year>2019</year>). <article-title>Hearing loss and Alzheimer's disease: a review</article-title>. <source>Int. Tinnitus J.</source> <volume>23</volume>, <fpage>79</fpage>&#x2013;<lpage>85</lpage>. doi: <pub-id pub-id-type="doi">10.5935/0946-5448.20190014</pub-id>, <pub-id pub-id-type="pmid">32009339</pub-id></mixed-citation></ref>
<ref id="ref109"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ray</surname><given-names>M.</given-names></name> <name><surname>Dening</surname><given-names>T.</given-names></name> <name><surname>Crosbie</surname><given-names>B.</given-names></name></person-group> (<year>2019</year>). <article-title>Dementia and hearing loss: a narrative review</article-title>. <source>Maturitas</source> <volume>128</volume>, <fpage>64</fpage>&#x2013;<lpage>69</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.maturitas.2019.08.001</pub-id>, <pub-id pub-id-type="pmid">31561826</pub-id></mixed-citation></ref>
<ref id="ref110"><mixed-citation publication-type="other"><person-group person-group-type="author"><name><surname>Rocks</surname><given-names>T.</given-names></name> <name><surname>Ferguson</surname><given-names>M.</given-names></name></person-group> &#x201C;Does training care-staff using interactive videos improve their hearing aid practical skills, understanding and perception of the importance of hearing aids.&#x201D; in <italic>British Academy of Audiology Conference Proceedings</italic> (<year>2013</year>).</mixed-citation></ref>
<ref id="ref111"><mixed-citation publication-type="book"><person-group person-group-type="author"><collab id="coll6">RNID</collab></person-group> (<year>2018</year>). <source>Supporting older people with hearing loss in care settings. A guide for managers and staff</source>. <publisher-loc>Great Britain: Peterborough, UK</publisher-loc>.</mixed-citation></ref>
<ref id="ref112"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sarant</surname><given-names>J. Z.</given-names></name></person-group> (<year>2023</year>). <article-title>ENHANCE: a comparative prospective longitudinal study of cognitive outcomes after 3&#x202F;years of hearing aid use in older adults</article-title>. <source>Front. Aging Neurosci.</source> <volume>15</volume>:<fpage>1302185</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fnagi.2023.1302185</pub-id></mixed-citation></ref>
<ref id="ref113"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sarant</surname><given-names>J.</given-names></name> <name><surname>Harris</surname><given-names>D.</given-names></name> <name><surname>Busby</surname><given-names>P.</given-names></name> <name><surname>Maruff</surname><given-names>P. T.</given-names></name> <name><surname>Schembri</surname><given-names>A.</given-names></name> <name><surname>Phillips</surname><given-names>J.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Hearing aid use and cognition in older adults: can we delay decline or even improve cognitive function?</article-title> <source>Alzheimers Dement.</source> <volume>16</volume>:<fpage>e038949</fpage>. doi: <pub-id pub-id-type="doi">10.1002/alz.038949</pub-id></mixed-citation></ref>
<ref id="ref114"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shukla</surname><given-names>A.</given-names></name></person-group> (<year>2020</year>). <article-title>Hearing loss, loneliness, and social isolation: a systematic review</article-title>. <source>Otolaryngol. Head Neck Surg.</source> <volume>162</volume>, <fpage>622</fpage>&#x2013;<lpage>633</lpage>. doi: <pub-id pub-id-type="doi">10.1177/0194599820910377</pub-id></mixed-citation></ref>
<ref id="ref115"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sinha</surname><given-names>U. K.</given-names></name> <name><surname>Hollen</surname><given-names>K. M.</given-names></name> <name><surname>Rodriguez</surname><given-names>R.</given-names></name> <name><surname>Miller</surname><given-names>C. A.</given-names></name></person-group> (<year>1993</year>). <article-title>Auditory system degeneration in Alzheimer's disease</article-title>. <source>Neurology</source> <volume>43</volume>, <fpage>779</fpage>&#x2013;<lpage>779</lpage>.</mixed-citation></ref>
<ref id="ref116"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Slade</surname><given-names>K.</given-names></name> <name><surname>Plack</surname><given-names>C. J.</given-names></name> <name><surname>Nuttall</surname><given-names>H. E.</given-names></name></person-group> (<year>2020</year>). <article-title>The effects of age-related hearing loss on the brain and cognitive function</article-title>. <source>Trends Neurosci.</source> <volume>43</volume>, <fpage>810</fpage>&#x2013;<lpage>821</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.tins.2020.07.005</pub-id>, <pub-id pub-id-type="pmid">32826080</pub-id></mixed-citation></ref>
<ref id="ref117"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Slaughter</surname><given-names>S. E.</given-names></name> <name><surname>Hopper</surname><given-names>T.</given-names></name> <name><surname>Ickert</surname><given-names>C.</given-names></name> <name><surname>Erin</surname><given-names>D. F.</given-names></name></person-group> (<year>2014</year>). <article-title>Identification of hearing loss among residents with dementia: perceptions of health care aides</article-title>. <source>Geriatr. Nurs.</source> <volume>35</volume>, <fpage>434</fpage>&#x2013;<lpage>440</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.gerinurse.2014.07.001</pub-id>, <pub-id pub-id-type="pmid">25212262</pub-id></mixed-citation></ref>
<ref id="ref118"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>S&#x00F6;derlund</surname><given-names>H.</given-names></name> <name><surname>Nyberg</surname><given-names>L.</given-names></name> <name><surname>Adolfsson</surname><given-names>R.</given-names></name> <name><surname>Nilsson</surname><given-names>L. G.</given-names></name> <name><surname>Launer</surname><given-names>L. J.</given-names></name></person-group> (<year>2003</year>). <article-title>High prevalence of white matter hyperintensities in normal aging: relation to blood pressure and cognition</article-title>. <source>Cortex</source> <volume>39</volume>, <fpage>1093</fpage>&#x2013;<lpage>1105</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0010-9452(08)70879-7</pub-id>, <pub-id pub-id-type="pmid">14584568</pub-id></mixed-citation></ref>
<ref id="ref119"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Srivastava</surname><given-names>S.</given-names></name></person-group> (<year>2017</year>). <article-title>The mitochondrial basis of aging and age-related disorders</article-title>. <source>Gene</source> <volume>8</volume>:<fpage>398</fpage>. doi: <pub-id pub-id-type="doi">10.3390/genes8120398</pub-id>, <pub-id pub-id-type="pmid">29257072</pub-id></mixed-citation></ref>
<ref id="ref120"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stancel-Lewis</surname><given-names>J.</given-names></name> <name><surname>Dening</surname><given-names>T.</given-names></name> <name><surname>Heffernan</surname><given-names>E.</given-names></name> <name><surname>Davis</surname><given-names>A. C.</given-names></name> <name><surname>Henshaw</surname><given-names>H.</given-names></name></person-group> (<year>2025</year>). <article-title>Hearing screening for healthy ageing: the UK should take a targeted approach</article-title>. <source>Gerontologist</source> <volume>gnaf295</volume>. doi: <pub-id pub-id-type="doi">10.1093/geront/gnaf295</pub-id></mixed-citation></ref>
<ref id="ref121"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stern</surname><given-names>Y.</given-names></name> <name><surname>Barnes</surname><given-names>C. A.</given-names></name> <name><surname>Grady</surname><given-names>C.</given-names></name> <name><surname>Jones</surname><given-names>R. N.</given-names></name> <name><surname>Raz</surname><given-names>N.</given-names></name></person-group> (<year>2019</year>). <article-title>Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience</article-title>. <source>Neurobiol. Aging</source> <volume>83</volume>, <fpage>124</fpage>&#x2013;<lpage>129</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.neurobiolaging.2019.03.022</pub-id>, <pub-id pub-id-type="pmid">31732015</pub-id></mixed-citation></ref>
<ref id="ref122"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tai</surname><given-names>C.-J.</given-names></name> <name><surname>Tseng</surname><given-names>T.-G.</given-names></name> <name><surname>Hsiao</surname><given-names>Y.-H.</given-names></name> <name><surname>Kuo</surname><given-names>T.-A.</given-names></name> <name><surname>Huang</surname><given-names>C.-Y.</given-names></name> <name><surname>Yang</surname><given-names>Y.-H.</given-names></name> <etal/></person-group>. (<year>2021</year>). <article-title>Effects of hearing impairment and hearing aid use on the incidence of cognitive impairment among community-dwelling older adults: evidence from the Taiwan longitudinal study on aging (TLSA)</article-title>. <source>BMC Geriatr.</source> <volume>21</volume>, <fpage>1</fpage>&#x2013;<lpage>10</lpage>. doi: <pub-id pub-id-type="doi">10.1186/s12877-021-02012-4</pub-id>, <pub-id pub-id-type="pmid">33482736</pub-id></mixed-citation></ref>
<ref id="ref123"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tang</surname><given-names>D.</given-names></name> <name><surname>Tran</surname><given-names>Y.</given-names></name> <name><surname>Bennett</surname><given-names>R. J.</given-names></name> <name><surname>Lo</surname><given-names>C.</given-names></name> <name><surname>Lee</surname><given-names>J. N.</given-names></name> <name><surname>Turner</surname><given-names>J.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>The benefits of hearing aids for adults: a systematic umbrella review</article-title>. <source>Ear Hear.</source> <volume>46</volume>, <fpage>563</fpage>&#x2013;<lpage>570</lpage>. doi: <pub-id pub-id-type="doi">10.1097/aud.0000000000001620</pub-id>, <pub-id pub-id-type="pmid">39849317</pub-id></mixed-citation></ref>
<ref id="ref124"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thosar</surname><given-names>S.</given-names></name> <name><surname>Savant</surname><given-names>N. U.</given-names></name> <name><surname>Llano</surname><given-names>D. A.</given-names></name></person-group> (<year>2025</year>). <article-title>Hearing aid interventions to mitigate cognitive impairment: a critical review of the literature and meta-analysis</article-title>. <source>medRxiv</source> <volume>2025</volume>:<fpage>25324637</fpage>. doi: <pub-id pub-id-type="doi">10.1101/2025.03.25.25324637</pub-id></mixed-citation></ref>
<ref id="ref125"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tun</surname><given-names>P. A.</given-names></name> <name><surname>McCoy</surname><given-names>S.</given-names></name> <name><surname>Wingfield</surname><given-names>A.</given-names></name></person-group> (<year>2009</year>). <article-title>Aging, hearing acuity, and the attentional costs of effortful listening</article-title>. <source>Psychol. Aging</source> <volume>24</volume>:<fpage>761</fpage>. doi: <pub-id pub-id-type="doi">10.1037/a0014802</pub-id>, <pub-id pub-id-type="pmid">19739934</pub-id></mixed-citation></ref>
<ref id="ref126"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Uchida</surname><given-names>Y.</given-names></name> <name><surname>Sugiura</surname><given-names>S.</given-names></name> <name><surname>Nishita</surname><given-names>Y.</given-names></name> <name><surname>Saji</surname><given-names>N.</given-names></name> <name><surname>Sone</surname><given-names>M.</given-names></name> <name><surname>Ueda</surname><given-names>H.</given-names></name></person-group> (<year>2019</year>). <article-title>Age-related hearing loss and cognitive decline&#x2014;the potential mechanisms linking the two</article-title>. <source>Auris Nasus Larynx</source> <volume>46</volume>, <fpage>1</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.anl.2018.08.010</pub-id>, <pub-id pub-id-type="pmid">30177417</pub-id></mixed-citation></ref>
<ref id="ref127"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Engen</surname><given-names>K. J.</given-names></name> <name><surname>McLaughlin</surname><given-names>D. J.</given-names></name></person-group> (<year>2018</year>). <article-title>Eyes and ears: using eye tracking and pupillometry to understand challenges to speech recognition</article-title>. <source>Hear. Res.</source> <volume>369</volume>, <fpage>56</fpage>&#x2013;<lpage>66</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.heares.2018.04.013</pub-id>, <pub-id pub-id-type="pmid">29801981</pub-id></mixed-citation></ref>
<ref id="ref128"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Hooren</surname><given-names>S. A.</given-names></name></person-group> (<year>2005</year>). <article-title>Does cognitive function in older adults with hearing impairment improve by hearing aid use?</article-title> <source>Int. J. Audiol.</source> <volume>44</volume>, <fpage>265</fpage>&#x2013;<lpage>271</lpage>. doi: <pub-id pub-id-type="doi">10.1080/14992020500060370</pub-id></mixed-citation></ref>
<ref id="ref129"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vandenbroeke</surname><given-names>T.</given-names></name> <name><surname>Andries</surname><given-names>E.</given-names></name> <name><surname>Lammers</surname><given-names>M. J.</given-names></name> <name><surname>de Van Heyning</surname><given-names>P.</given-names></name> <name><surname>den Hofkens-Van Brandt</surname><given-names>A.</given-names></name> <name><surname>Vanderveken</surname><given-names>O.</given-names></name> <etal/></person-group>. (<year>2025</year>). <article-title>Cognitive changes up to 4 years after cochlear implantation in older adults: a prospective longitudinal study using the RBANS-H</article-title>. <source>Ear Hear.</source> <volume>46</volume>, <fpage>361</fpage>&#x2013;<lpage>370</lpage>. doi: <pub-id pub-id-type="doi">10.1097/AUD.0000000000001583</pub-id>, <pub-id pub-id-type="pmid">39228026</pub-id></mixed-citation></ref>
<ref id="ref130"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>V&#x00F6;lter</surname><given-names>C.</given-names></name> <name><surname>G&#x00F6;tze</surname><given-names>L.</given-names></name> <name><surname>Dazert</surname><given-names>S.</given-names></name> <name><surname>Falkenstein</surname><given-names>M.</given-names></name> <name><surname>Thomas</surname><given-names>J. P.</given-names></name></person-group> (<year>2018</year>). <article-title>Can cochlear implantation improve neurocognition in the aging population?</article-title> <source>Clin. Interv. Aging</source> <volume>13</volume>, <fpage>701</fpage>&#x2013;<lpage>712</lpage>. doi: <pub-id pub-id-type="doi">10.2147/CIA.S160517</pub-id>, <pub-id pub-id-type="pmid">29719382</pub-id></mixed-citation></ref>
<ref id="ref131"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Voss</surname><given-names>P.</given-names></name></person-group> (<year>2025</year>). <article-title>Prediction of hearing aid cognitive outcomes in age-related hearing loss</article-title>. <source>Front. Aging Neurosci.</source> <volume>17</volume>, <fpage>1</fpage>&#x2013;<lpage>7</lpage>. doi: <pub-id pub-id-type="doi">10.3389/fnagi.2025.1548526</pub-id></mixed-citation></ref>
<ref id="ref133"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>X.</given-names></name> <name><surname>Xu</surname><given-names>P.</given-names></name> <name><surname>Li</surname><given-names>P.</given-names></name> <name><surname>Wang</surname><given-names>Z.</given-names></name> <name><surname>Zhao</surname><given-names>F.</given-names></name> <name><surname>Gao</surname><given-names>Z.</given-names></name> <etal/></person-group>. (<year>2016</year>). <article-title>Alterations in gray matter volume due to unilateral hearing loss</article-title>. <source>Sci. Rep.</source> <volume>6</volume>:<fpage>25811</fpage>. doi: <pub-id pub-id-type="doi">10.1038/srep25811</pub-id>, <pub-id pub-id-type="pmid">27174521</pub-id></mixed-citation></ref>
<ref id="ref134"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wayne</surname><given-names>R. V.</given-names></name> <name><surname>Johnsrude</surname><given-names>I. S.</given-names></name></person-group> (<year>2015</year>). <article-title>A review of causal mechanisms underlying the link between age-related hearing loss and cognitive decline</article-title>. <source>Ageing Res. Rev.</source> <volume>23</volume>, <fpage>154</fpage>&#x2013;<lpage>166</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.arr.2015.06.002</pub-id></mixed-citation></ref>
<ref id="ref135"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Witham</surname><given-names>M. D.</given-names></name> <name><surname>Anderson</surname><given-names>E.</given-names></name> <name><surname>Carroll</surname><given-names>C.</given-names></name> <name><surname>Dark</surname><given-names>P. M.</given-names></name> <name><surname>Down</surname><given-names>K.</given-names></name> <name><surname>Hall</surname><given-names>A. S.</given-names></name> <etal/></person-group>. (<year>2020</year>). <article-title>Developing a roadmap to improve trial delivery for under-served groups: results from a UK multi-stakeholder process</article-title>. <source>Trials</source> <volume>21</volume>, <fpage>1</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.1186/s13063-020-04613-7</pub-id>, <pub-id pub-id-type="pmid">32738919</pub-id></mixed-citation></ref>
<ref id="ref136"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll8">World Health Organization</collab></person-group> <source>Hearing screening: Considerations for implementation</source>. Geneva, Switzerland, World Health Organisation. (<year>2021</year>)</mixed-citation></ref>
<ref id="ref137"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll9">World Health Organization</collab></person-group>. Dementia factsheet. (<year>2023</year>). Available online at: <ext-link xlink:href="https://www.who.int/news-room/fact-sheets/detail/dementia" ext-link-type="uri">https://www.who.int/news-room/fact-sheets/detail/dementia</ext-link> (Accessed October 29, 2025).</mixed-citation></ref>
<ref id="ref138"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll10">World Health Organization</collab></person-group>. Deafness and hearing loss factsheet. (<year>2024</year>); Available online at: <ext-link xlink:href="https://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss" ext-link-type="uri">https://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss</ext-link> (Accessed October 29, 2025).</mixed-citation></ref>
<ref id="ref132"><mixed-citation publication-type="other"><person-group person-group-type="author"><collab id="coll7">World Health Organisation</collab></person-group>. <source>Global action plan on dementia (2017&#x2013;2025) Geneva, Switzerland, World Health Organisation.</source> (<year>2025</year>).</mixed-citation></ref>
<ref id="ref139"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xiao</surname><given-names>C.</given-names></name> <name><surname>Liu</surname><given-names>Y.</given-names></name> <name><surname>Xu</surname><given-names>J.</given-names></name> <name><surname>Gan</surname><given-names>X.</given-names></name> <name><surname>Xiao</surname><given-names>Z.</given-names></name></person-group> (<year>2018</year>). <article-title>Septal and hippocampal neurons contribute to auditory relay and fear conditioning</article-title>. <source>Front. Cell. Neurosci.</source> <volume>12</volume>:<fpage>102</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fncel.2018.00102</pub-id>, <pub-id pub-id-type="pmid">29713265</pub-id></mixed-citation></ref>
<ref id="ref140"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>W.</given-names></name> <name><surname>Zhang</surname><given-names>C.</given-names></name> <name><surname>Li</surname><given-names>J.-Q.</given-names></name> <name><surname>Tan</surname><given-names>C.-C.</given-names></name> <name><surname>Cao</surname><given-names>X.-P.</given-names></name> <name><surname>Tan</surname><given-names>L.</given-names></name> <etal/></person-group>. (<year>2019</year>). <article-title>Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study</article-title>. <source>Aging (Albany NY)</source> <volume>11</volume>:<fpage>3156</fpage>. doi: <pub-id pub-id-type="doi">10.18632/aging.101971</pub-id>, <pub-id pub-id-type="pmid">31118310</pub-id></mixed-citation></ref>
<ref id="ref141"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yamada</surname><given-names>Y.</given-names></name> <name><surname>Vlachova</surname><given-names>M.</given-names></name> <name><surname>Richter</surname><given-names>T.</given-names></name> <name><surname>Finne-Soveri</surname><given-names>H.</given-names></name> <name><surname>Gindin</surname><given-names>J.</given-names></name> <name><surname>van der Roest</surname><given-names>H.</given-names></name> <etal/></person-group>. (<year>2014</year>). <article-title>Prevalence and correlates of hearing and visual impairments in European nursing homes: results from the SHELTER study</article-title>. <source>J. Am. Med. Dir. Assoc.</source> <volume>15</volume>, <fpage>738</fpage>&#x2013;<lpage>743</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jamda.2014.05.012</pub-id>, <pub-id pub-id-type="pmid">24984787</pub-id></mixed-citation></ref>
<ref id="ref142"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>Z.</given-names></name> <name><surname>Ni</surname><given-names>J.</given-names></name> <name><surname>Teng</surname><given-names>Y.</given-names></name> <name><surname>Su</surname><given-names>M.</given-names></name> <name><surname>Wei</surname><given-names>M.</given-names></name> <name><surname>Li</surname><given-names>T.</given-names></name> <etal/></person-group>. (<year>2022</year>). <article-title>Effect of hearing aids on cognitive functions in middle-aged and older adults with hearing loss: a systematic review and meta-analysis</article-title>. <source>Front. Aging Neurosci.</source> <volume>14</volume>:<fpage>1017882</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fnagi.2022.1017882</pub-id>, <pub-id pub-id-type="pmid">36452439</pub-id></mixed-citation></ref>
<ref id="ref143"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yeo</surname><given-names>B. S. Y.</given-names></name> <name><surname>Song</surname><given-names>H. J. J. M. D.</given-names></name> <name><surname>Toh</surname><given-names>E. M. S.</given-names></name> <name><surname>Ng</surname><given-names>L. S.</given-names></name> <name><surname>Ho</surname><given-names>C. S. H.</given-names></name> <name><surname>Ho</surname><given-names>R.</given-names></name> <etal/></person-group>. (<year>2023</year>). <article-title>Association of Hearing Aids and Cochlear Implants with Cognitive Decline and dementia: a systematic review and Meta-analysis</article-title>. <source>JAMA Neurol.</source> <volume>80</volume>, <fpage>134</fpage>&#x2013;<lpage>141</lpage>. doi: <pub-id pub-id-type="doi">10.1001/jamaneurol.2022.4427</pub-id>, <pub-id pub-id-type="pmid">36469314</pub-id></mixed-citation></ref>
<ref id="ref144"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>R. C.</given-names></name></person-group> (<year>2024</year>). <article-title>Adult-onset hearing loss and incident cognitive impairment and dementia - a systematic review and meta-analysis of cohort studies</article-title>. <source>Ageing Res. Rev.</source> <volume>98</volume>:<fpage>102346</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.arr.2024.102346</pub-id></mixed-citation></ref>
<ref id="ref145"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>R. C.</given-names></name></person-group> (<year>2025</year>). <article-title>Early detection and management of hearing loss to reduce dementia risk in older adults with mild cognitive impairment: findings from the treating auditory impairment and cognition trial (TACT)</article-title>. <source>Age Ageing</source> <volume>54</volume>, <fpage>1</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.1093/ageing/afaf004</pub-id></mixed-citation></ref>
<ref id="ref146"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>L.</given-names></name> <name><surname>Wang</surname><given-names>J.</given-names></name> <name><surname>Sun</surname><given-names>H.</given-names></name> <name><surname>Feng</surname><given-names>G.</given-names></name> <name><surname>Gao</surname><given-names>Z.</given-names></name></person-group> (<year>2022</year>). <article-title>Interactions between the hippocampus and the auditory pathway</article-title>. <source>Neurobiol. Learn. Mem.</source> <volume>189</volume>:<fpage>107589</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.nlm.2022.107589</pub-id>, <pub-id pub-id-type="pmid">35124220</pub-id></mixed-citation></ref>
</ref-list>
<fn-group>
<fn fn-type="custom" custom-type="edited-by" id="fn0001">
<p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/122418/overview">Paul Hinckley Delano</ext-link>, University of Chile, Chile</p>
</fn>
<fn fn-type="custom" custom-type="reviewed-by" id="fn0002">
<p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2276154/overview">Jae-hyeon Park</ext-link>, National Institute on Aging (NIH), United States</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/402410/overview">Maria Isabel Behrens</ext-link>, University of Chile, Chile</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3290593/overview">Penny Gosselin</ext-link>, Alberta Health Services, Canada</p>
</fn>
</fn-group>
</back>
</article>