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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Child Adolesc. Psychiatry</journal-id><journal-title-group>
<journal-title>Frontiers in Child and Adolescent Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Child Adolesc. Psychiatry</abbrev-journal-title></journal-title-group>
<issn pub-type="epub">2813-4540</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/frcha.2025.1648195</article-id>
<article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Prevalence of post-traumatic stress disorder and its association with adverse childhood experiences among refugee and host-community children and adolescents in Jordan</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>Abu Khudair</surname><given-names>Sara</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
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<contrib contrib-type="author" corresp="yes"><name><surname>Khader</surname><given-names>Yousef</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref>
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<contrib contrib-type="author"><name><surname>Al Kouri</surname><given-names>Osama</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/2322332/overview"/>
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<contrib contrib-type="author"><name><surname>Al Nsour</surname><given-names>Mohannad</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="author-notes" rid="fn001"><sup>&#x2020;</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/1399149/overview" /><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Project administration" vocab-term-identifier="https://credit.niso.org/contributor-roles/project-administration/">Project administration</role><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Funding acquisition" vocab-term-identifier="https://credit.niso.org/contributor-roles/funding-acquisition/">Funding acquisition</role><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Resources" vocab-term-identifier="https://credit.niso.org/contributor-roles/resources/">Resources</role><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role></contrib>
<contrib contrib-type="author"><name><surname>Tanaka</surname><given-names>Eizaburo</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<xref ref-type="author-notes" rid="fn001"><sup>&#x2020;</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/2895005/overview" /><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="methodology" vocab-term-identifier="https://credit.niso.org/contributor-roles/methodology/">Methodology</role><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Project administration" vocab-term-identifier="https://credit.niso.org/contributor-roles/project-administration/">Project administration</role><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Validation" vocab-term-identifier="https://credit.niso.org/contributor-roles/validation/">Validation</role><role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role></contrib>
</contrib-group>
<aff id="aff1"><label>1</label><institution>Eastern Mediterranean Public Health Network (EMPHNET)</institution>, <city>Amman</city>, <country country="jo">Jordan</country></aff>
<aff id="aff2"><label>2</label><institution>Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology</institution>, <city>Irbid</city>, <country country="jo">Jordan</country></aff>
<aff id="aff3"><label>3</label><institution>Faculty of Nursing, Yarmouk University</institution>, <city>Irbid</city>, <country country="jo">Jordan</country></aff>
<aff id="aff4"><label>4</label><institution>Center for Research on Counseling and Support Services, The University of Tokyo</institution>, <city>Tokyo</city>, <country country="jp">Japan</country></aff>
<author-notes>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> Yousef Khader <email xlink:href="mailto:yskhader@just.edu.jo">yskhader@just.edu.jo</email></corresp>
<fn fn-type="other" id="fn001"><label>&#x2020;</label><p>ORCID Sara Abu Khudair <uri xlink:href="https://orcid.org/0000-0002-6172-6898">orcid.org/0000-0002-6172-6898</uri> Yousef Khader <uri xlink:href="https://orcid.org/0000-0002-7830-6857">orcid.org/0000-0002-7830-6857</uri> Osama Al Kouri <uri xlink:href="https://orcid.org/0000-0002-3268-2259">orcid.org/0000-0002-3268-2259</uri> Mohannad Al Nsour <uri xlink:href="https://orcid.org/0000-0003-1212-1611">orcid.org/0000-0003-1212-1611</uri> Eizaburo Tanaka <uri xlink:href="https://orcid.org/0000-0001-9979-0222">orcid.org/0000-0001-9979-0222</uri></p></fn>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-01-12"><day>12</day><month>01</month><year>2026</year></pub-date>
<pub-date publication-format="electronic" date-type="collection"><year>2025</year></pub-date>
<volume>4</volume><elocation-id>1648195</elocation-id>
<history>
<date date-type="received"><day>16</day><month>06</month><year>2025</year></date>
<date date-type="rev-recd"><day>30</day><month>11</month><year>2025</year></date>
<date date-type="accepted"><day>15</day><month>12</month><year>2025</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2026 Abu Khudair, Khader, Al Kouri, Al Nsour and Tanaka.</copyright-statement>
<copyright-year>2026</copyright-year><copyright-holder>Abu Khudair, Khader, Al Kouri, Al Nsour and Tanaka</copyright-holder><license><ali:license_ref start_date="2026-01-12">https://creativecommons.org/licenses/by/4.0/</ali:license_ref><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license>
</permissions>
<abstract><sec><title>Background</title>
<p>Exposure to adverse childhood experiences (ACEs) is linked to the development of various psychological disorders, particularly post-traumatic stress disorder (PTSD). This study aimed to determine the prevalence rates of ACEs and high PTSD symptoms and to investigate their association among children and adolescents in Jordan.</p>
</sec><sec><title>Methods</title>
<p>A large-scale school-based national survey was conducted among children and adolescents in the host and refugee populations aged 8&#x2013;18 years in Jordan, utilizing a multi-stage stratified cluster sampling technique. The study questionnaires contained standardized and psychometrically validated instruments to assess ACEs and PTSD.</p>
</sec><sec><title>Results</title>
<p>A total of 8,000 children and adolescents were included. The most prevalent ACEs among children were COVID-19 infection (43.2&#x0025;), food insecurity or inadequate clothing (22.1&#x0025;), and exam failure (21.7&#x0025;), while for adolescents, COVID-19 infection (60.3&#x0025;), exam failure (43.2&#x0025;), and the death of a family member (31.7&#x0025;). High PTSD symptoms were observed in 31.4&#x0025;, more prevalent in females than males (33.0&#x0025; vs. 29.3&#x0025;, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.003) and adolescents than children (35.5&#x0025; vs. 24.6&#x0025;, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). For both children and adolescents, feeling unloved by family was significantly associated with high PTSD symptoms (OR&#x2009;&#x003D;&#x2009;2.1, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). Other significant ACEs included death of a family member (children: OR&#x2009;&#x003D;&#x2009;1.9; adolescents: OR&#x2009;&#x003D;&#x2009;1.8) and food insecurity/inadequate clothing (OR&#x2009;&#x003D;&#x2009;1.7 for both). In children, exam failure was significant (OR&#x2009;&#x003D;&#x2009;1.5), while in adolescents, it included physical assault (OR&#x2009;&#x003D;&#x2009;1.4), COVID-19 infection (OR&#x2009;&#x003D;&#x2009;1.3), serious accidents (OR&#x2009;&#x003D;&#x2009;1.3), and emotional abuse (OR&#x2009;&#x003D;&#x2009;1.6). Experiencing &#x2265;4 ACEs greatly increased PTSD odds (children: OR&#x2009;&#x003D;&#x2009;5.0, adolescents: OR&#x2009;&#x003D;&#x2009;4.3; <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001).</p>
</sec><sec><title>Conclusion</title>
<p>Findings highlight a high prevalence of PTSD among children and adolescents exposed to ACEs, with multiple ACEs linked to higher PTSD symptoms and a cumulative pattern further increasing this risk. Results underscore the need for targeted interventions addressing key ACEs by age group and the development of comprehensive prevention programs involving parents, families, schools, communities, and broader society. Interventions should also aim to mitigate the cumulative impact of multiple ACEs and address them collectively rather than individually.</p>
</sec>
</abstract>
<kwd-group>
<kwd>adolescent</kwd>
<kwd>adverse childhood experiences</kwd>
<kwd>child</kwd>
<kwd>Jordan</kwd>
<kwd>mental health</kwd>
<kwd>post-traumatic stress disorder</kwd>
<kwd>refugees</kwd>
</kwd-group><funding-group><funding-statement>The author(s) declared that financial support was received for this work and/or its publication. This study was funded by the Japan International Cooperation Agency (JICA) and JSPS KAKENHI (Grant Numbers JP23K01722).</funding-statement></funding-group><counts>
<fig-count count="1"/>
<table-count count="4"/><equation-count count="0"/><ref-count count="68"/><page-count count="12"/><word-count count="0"/></counts><custom-meta-group><custom-meta><meta-name>section-at-acceptance</meta-name><meta-value>Child Mental Health and Interventions</meta-value></custom-meta></custom-meta-group>
</article-meta>
</front>
<body><sec id="s1" sec-type="intro"><title>Introduction</title>
<p>Adverse childhood experiences (ACEs) are potentially traumatic events occurring before the age of 18, including physical, emotional, and sexual abuse, physical and emotional neglect, and household dysfunction, including domestic violence, substance abuse, mental illness, parental separation, and incarceration (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>). Exposure to ACEs is linked to the development of various psychological disorders, particularly post-traumatic stress disorder (PTSD) (<xref ref-type="bibr" rid="B3">3</xref>, <xref ref-type="bibr" rid="B4">4</xref>). In a study involving young girls, a gradual increase in the likelihood of probable PTSD was observed with higher ACE exposure levels, with a single ACE exposure such as firearm abuse or rape, increasing the likelihood of probable PTSD nearly fivefold (<xref ref-type="bibr" rid="B5">5</xref>).</p>
<p>Symptoms of PTSD in children and adolescents include reliving the trauma through intrusive thoughts and flashbacks, avoiding trauma-related triggers, experiencing negative mood shifts, and heightened arousal and reactivity, which can hinder a child&#x0027;s development, influencing their emotional, cognitive, and social progress (<xref ref-type="bibr" rid="B6">6</xref>). PTSD in children is linked to depression, aggression, academic struggles, and social challenges (<xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B8">8</xref>). Also, the prolonged psychological distress associated with PTSD can increase the likelihood of developing chronic diseases and conditions such as hypertension, hyperlipidemia, obesity, and cardiovascular disease (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B10">10</xref>).</p>
<p>Recent findings from a nationwide survey highlighted major mental health and psychosocial challenges among children and adolescents in Jordan (<xref ref-type="bibr" rid="B11">11</xref>). In general, Jordan faces a combination of challenges including regional instability, a large influx of refugees, economic hardship, specific cultural norms surrounding mental health, such as stigma and limited mental health resources. This creates a complex environment in Jordan that heightens the risk of negative mental health outcomes, including ACEs and PTSD, among children and adolescents, particularly among refugee populations (<xref ref-type="bibr" rid="B12">12</xref>). A comprehensive study from Jordan revealed a high prevalence of child abuse and its negative consequences, coupled with a lack of awareness about child abuse and its impacts (<xref ref-type="bibr" rid="B13">13</xref>).</p>
<p>Despite PTSD&#x0027;s profound impact on children, most studies on ACEs and PTSD lack representative samples and few focus on low-income countries (<xref ref-type="bibr" rid="B14">14</xref>, <xref ref-type="bibr" rid="B15">15</xref>). In Jordan, few studies have examined PTSD and its relationship with ACEs, particularly using a representative sample that includes a broad age range encompassing both children and adolescents (<xref ref-type="bibr" rid="B16">16</xref>). Additionally, children and adolescents form a large share of Jordan&#x0027;s population, and Jordan hosts one of the world&#x0027;s largest refugee populations relative to its size (<xref ref-type="bibr" rid="B17">17</xref>, <xref ref-type="bibr" rid="B18">18</xref>). Also, both refugee and host-community youth in Jordan face significant stressors. Refugee children experience displacement, loss, and instability, while host-community children often face overcrowded schools and strained services (<xref ref-type="bibr" rid="B19">19</xref>, <xref ref-type="bibr" rid="B20">20</xref>). These overlapping pressures increase vulnerability in both groups. Therefore, this study aimed to determine the prevalence rates of ACEs and high PTSD symptoms and to investigate the association between ACE and PTSD among children and adolescents living in Jordan. This study is crucial to inform the development of interventions and prevention policies specifically tailored to this population. Findings are important for mental health practitioners, educators, policymakers, and caregivers, enabling them to provide effective support and minimize the enduring effects of trauma.</p>
</sec>
<sec id="s2" sec-type="methods"><title>Methods</title>
<sec id="s2a"><title>Study design, sampling</title>
<p>The detailed methods of this large-scale national school-based cross-sectional survey conducted among children and adolescents in Jordan, including sample selection, data collection protocols, and the translation process, are thoroughly described in another paper (<xref ref-type="bibr" rid="B11">11</xref>). In summary, the survey aimed to capture a nationally representative sample, including Jordanian children and adolescents as well as Syrian and Palestinian refugees enrolled in grades 3&#x2013;12. A multi-stage stratified cluster sampling technique was employed. Schools were selected from different governing authorities, including the Ministry of Education (MoE), private schools, and UNRWA schools for Palestinian refugees. Stratification was based on region (North, Central, and South) and governorate. Special attention was given to refugee contexts, including both regular MoE schools and Syrian second-shift schools, further stratified by gender. Students who had dropped out of formal schooling were included through non-formal education centers, with data collected from centers in the northern and central regions of Jordan, where most students enrolled in non-formal education programs are located. The sample of non-formal education centers was also gender-balanced.</p>
</sec>
<sec id="s2b"><title>Data collection</title>
<p>Data collection took place between December 2022 and April 2023, during which trained data collectors visited schools and non-formal education centers. A pilot test was conducted in two schools in northern Jordan to evaluate the survey content and data collection process, and the researchers conducted regular monitoring of data quality. The study followed ethical guidelines, with informed consent obtained from caregivers and adolescents.</p>
</sec>
<sec id="s2c"><title>Study instruments</title>
<p>The survey included two versions: a proxy parent version for parents of students in grades 3&#x2013;6 and a self-report version for students in grades 7&#x2013;12. The expected age of students in the parent-report version ranged from 8 to 11 years, and 12 to 18 years for the self-report version, according to the MoE educational ladder. Students in non-formal education programs completed the self-report version, as they were 12 years of age or older and therefore fit the self-report category of the study.</p>
<p>For instruments available only as self-report versions, questions were reworded by the research team to reflect parents&#x2019; responses about their children. Permission to use all tools was obtained from their respective developers. When an Arabic version was not available, forward&#x2013;backward translation procedures were followed for both versions. The translated versions were then piloted within the target population. Modifications were minimal and focused primarily on enhancing clarity. Cronbach&#x0027;s alpha, measuring internal reliability, for the Children&#x0027;s Revised Impact of Event Scale (CRIES-13), used to assess post-traumatic stress disorder (PTSD) symptoms, was 0.876 for children and 0.883 for adolescents, indicating strong internal consistency. The mean inter-item correlation was 0.356 for children and 0.367 for adolescents, both within acceptable ranges.</p>
<sec id="s2c1"><title>Children&#x0027;s and adolescents&#x2019; characteristics</title>
<p>A total of 32 variables were used to capture the characteristics of the children and adolescents, including school characteristics, demographics, parental demographics, medical history (COVID-19 infection history, chronic diseases, special needs, regular medication use, mental health problems and family history of mental health issues), insurance status, length of stay for Syrian refugees, and socioeconomic status (SES).</p>
</sec>
</sec>
<sec id="s2d"><title>Adverse childhood experience (ACE)</title>
<p>Adverse childhood experiences were assessed using the Adverse Childhood Experiences (ACEs) Questionnaire and the Life Events Checklist for DSM-5 (LEC-5). The ACEs questionnaire is a 10-item instrument derived from the CDC&#x2013;Kaiser Permanente ACEs Study (<xref ref-type="bibr" rid="B21">21</xref>). The list was revised and adapted to exclude sensitive questions such as sexual abuse; the final version consisted of four items assessing physical abuse, verbal abuse, physical neglect, and emotional neglect. The LEC-5 is a self-report measure designed to screen for potentially traumatic events across the lifespan (<xref ref-type="bibr" rid="B22">22</xref>), consisting of 16 events known to be associated with PTSD and one optional item assessing any other extraordinarily stressful event. Eleven LEC-5 items were included in the study tool to complement the ACEs questionnaire, along with three additional items related to exam failure and COVID-19. Responses were limited to two choices: &#x201C;happened to me&#x201D; and &#x201C;did not happen to me&#x201D;.</p>
<sec id="s2d1"><title>The children&#x0027;s impact of event scale-13 (CRIES -13)</title>
<p>PTSD symptoms were assessed using the CRIES-13, which includes 13 items measuring childhood PTSD symptoms (<xref ref-type="bibr" rid="B23">23</xref>, <xref ref-type="bibr" rid="B24">24</xref>). It comprises an overall score and three subscales: intrusion, avoidance, and arousal. A cut-off score of 30 has been shown to be effective for screening for PTSD (<xref ref-type="bibr" rid="B23">23</xref>) and was used to categorize those with high PTSD symptoms. Higher scores indicate higher symptom severity.</p>
<p>The study questionnaire incorporated conditional branching for the ACEs and PTSD sections. Only those who reported experiencing at least one ACE proceeded to the ACE section to identify the most distressing ACE they or their children had encountered. They were then eligible to complete the CRIES-13 section.</p>
</sec>
</sec>
<sec id="s2e"><title>Statistical analysis</title>
<p>Data analysis was conducted using IBM SPSS 24 (IBM Corp., 2016). Frequencies and percentages were used to describe categorical variables. Chi-square tests were used to compare the prevalence of ACEs between children and adolescents, examine differences in PTSD categories across groups, and to compare PTSD prevalence according to ACE exposure. Multivariate binary logistic regression was used to analyze the association between PTSD and ACEs. The model included all studied ACEs, including non-significant ones, to allow a comprehensive evaluation of all potential contributors to PTSD. Retaining non-significant ACEs minimizes bias and ensures the model reflects the full range of experiences. The effects of ACEs were adjusted for gender and chronic illness, as both were significant in the model. Other socio-demographic variables were not significantly associated with PTSD and were excluded. A <italic>p</italic>-value of &#x003C;0.05 was considered statistically significant.</p>
</sec>
</sec>
<sec id="s3" sec-type="results"><title>Results</title>
<sec id="s3a"><title>Participants characteristics</title>
<p>A total of 8,000 children and adolescents aged 8&#x2013;18 years were included, with 42.9&#x0025; boys and 57.1&#x0025; girls. Of these, 44.9&#x0025; were children (8&#x2013;11 years), and 55.1&#x0025; were adolescents (12&#x2013;18 years). Most participants (64.2&#x0025;) attended public schools, and the majority lived in the central (46.0&#x0025;) and northern (42.3&#x0025;) regions of Jordan, with 11.7&#x0025; residing in the southern region. Jordanians were the largest group, making up 57.8&#x0025; of children and 66.2&#x0025; of adolescents, followed by Syrians living outside refugee camps. About 77.5&#x0025; of participants reported their fathers were employed, while 22.6&#x0025; reported their mothers were working. Around half of the participants belonged to medium-affluent families, and 22.2&#x0025; had a confirmed COVID-19 infection.</p>
</sec>
<sec id="s3b"><title>The adverse childhood experiences</title>
<p><xref ref-type="table" rid="T1">Table&#x00A0;1</xref> shows the prevalence rates of ACEs among children and adolescents. The most prevalent ACEs among children were being infected or having a family member infected with COVID-19 (43.2&#x0025;), food insecurity or inadequate clothing (22.1&#x0025;), and exam failure (21.7&#x0025;), while for adolescents, being infected or having a family member infected with COVID-19 (60.3&#x0025;), exam failure (43.2&#x0025;), and the sudden accidental death of a family member (31.7&#x0025;). Almost all ACEs were significantly more common among adolescents compared to children.</p>
<table-wrap id="T1" position="float"><label>Table&#x00A0;1</label>
<caption><p>The prevalence of adverse childhood experiences among children and adolescents.</p></caption>
<table>
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left" rowspan="2">Event</th>
<th valign="top" align="center" colspan="2">Children (8&#x2013;11 years)<break/><italic>n</italic>&#x2009;&#x003D;&#x2009;3,593</th>
<th valign="top" align="center" colspan="2">Adolescents (12&#x2013;18 years)<break/><italic>n</italic>&#x2009;&#x003D;&#x2009;4,407</th>
<th valign="top" align="center" colspan="2">Total<break/><italic>N</italic>&#x2009;&#x003D;&#x2009;8,000</th>
</tr>
<tr>
<th valign="top" align="center"><italic>n</italic></th>
<th valign="top" align="center">&#x0025;</th>
<th valign="top" align="center"><italic>n</italic></th>
<th valign="top" align="center">&#x0025;</th>
<th valign="top" align="center"><italic>N</italic></th>
<th valign="top" align="center">&#x0025;</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Infected or a family member infected with COVID-19</td>
<td valign="top" align="center">1,530</td>
<td valign="top" align="center">43.2</td>
<td valign="top" align="center">2,611</td>
<td valign="top" align="center">60.3</td>
<td valign="top" align="center">4,141</td>
<td valign="top" align="center">52.6</td>
</tr>
<tr>
<td valign="top" align="left">Failing an exam</td>
<td valign="top" align="center">772</td>
<td valign="top" align="center">21.7</td>
<td valign="top" align="center">1,878</td>
<td valign="top" align="center">43.2</td>
<td valign="top" align="center">2,650</td>
<td valign="top" align="center">33.5</td>
</tr>
<tr>
<td valign="top" align="left">The sudden accidental death of any of the family members</td>
<td valign="top" align="center">540</td>
<td valign="top" align="center">15.2</td>
<td valign="top" align="center">1,373</td>
<td valign="top" align="center">31.7</td>
<td valign="top" align="center">1,913</td>
<td valign="top" align="center">24.3</td>
</tr>
<tr>
<td valign="top" align="left">Physical assault (being attacked, hit, slapped, kicked, beaten up)</td>
<td valign="top" align="center">528</td>
<td valign="top" align="center">14.9</td>
<td valign="top" align="center">1,004</td>
<td valign="top" align="center">23.2</td>
<td valign="top" align="center">1,532</td>
<td valign="top" align="center">19.4</td>
</tr>
<tr>
<td valign="top" align="left">Insulted or belittled by a parent or other adult in the house</td>
<td valign="top" align="center">526</td>
<td valign="top" align="center">14.8</td>
<td valign="top" align="center">992</td>
<td valign="top" align="center">22.9</td>
<td valign="top" align="center">1,518</td>
<td valign="top" align="center">19.3</td>
</tr>
<tr>
<td valign="top" align="left">Car Accident</td>
<td valign="top" align="center">282</td>
<td valign="top" align="center">7.9</td>
<td valign="top" align="center">1,215</td>
<td valign="top" align="center">28.0</td>
<td valign="top" align="center">1,497</td>
<td valign="top" align="center">19.0</td>
</tr>
<tr>
<td valign="top" align="left">Did not have enough to eat, or had to wear old clothes</td>
<td valign="top" align="center">784</td>
<td valign="top" align="center">22.1</td>
<td valign="top" align="center">654</td>
<td valign="top" align="center">15.1</td>
<td valign="top" align="center">1,438</td>
<td valign="top" align="center">18.2</td>
</tr>
<tr>
<td valign="top" align="left">Feeling that no one in the family loves you/your child</td>
<td valign="top" align="center">310</td>
<td valign="top" align="center">8.7</td>
<td valign="top" align="center">953</td>
<td valign="top" align="center">22.0</td>
<td valign="top" align="center">1,263</td>
<td valign="top" align="center">16.0</td>
</tr>
<tr>
<td valign="top" align="left">Severely beaten by a parent or other adult in the house</td>
<td valign="top" align="center">234</td>
<td valign="top" align="center">6.6</td>
<td valign="top" align="center">694</td>
<td valign="top" align="center">16.1</td>
<td valign="top" align="center">928</td>
<td valign="top" align="center">11.8</td>
</tr>
<tr>
<td valign="top" align="left">Serious accidents at home, school, or during recreational activity</td>
<td valign="top" align="center">209</td>
<td valign="top" align="center">5.9</td>
<td valign="top" align="center">674</td>
<td valign="top" align="center">15.5</td>
<td valign="top" align="center">883</td>
<td valign="top" align="center">11.2</td>
</tr>
<tr>
<td valign="top" align="left">Fire or explosion</td>
<td valign="top" align="center">207</td>
<td valign="top" align="center">5.8</td>
<td valign="top" align="center">670</td>
<td valign="top" align="center">15.4</td>
<td valign="top" align="center">877</td>
<td valign="top" align="center">11.1</td>
</tr>
<tr>
<td valign="top" align="left">Combat or exposure to a warzone</td>
<td valign="top" align="center">198</td>
<td valign="top" align="center">5.6</td>
<td valign="top" align="center">542</td>
<td valign="top" align="center">12.5</td>
<td valign="top" align="center">740</td>
<td valign="top" align="center">9.4</td>
</tr>
<tr>
<td valign="top" align="left">Serious injury or harm you/your child caused to someone else</td>
<td valign="top" align="center">102</td>
<td valign="top" align="center">2.9</td>
<td valign="top" align="center">615</td>
<td valign="top" align="center">14.3</td>
<td valign="top" align="center">717</td>
<td valign="top" align="center">9.2</td>
</tr>
<tr>
<td valign="top" align="left">A family member died from COVID-19</td>
<td valign="top" align="center">166</td>
<td valign="top" align="center">4.7</td>
<td valign="top" align="center">454</td>
<td valign="top" align="center">10.5</td>
<td valign="top" align="center">620</td>
<td valign="top" align="center">7.9</td>
</tr>
<tr>
<td valign="top" align="left">Life-threatening illness or injury</td>
<td valign="top" align="center">126</td>
<td valign="top" align="center">3.5</td>
<td valign="top" align="center">489</td>
<td valign="top" align="center">11.3</td>
<td valign="top" align="center">615</td>
<td valign="top" align="center">7.8</td>
</tr>
<tr>
<td valign="top" align="left">Natural disasters (floods, intense streams of water, or earthquakes)</td>
<td valign="top" align="center">95</td>
<td valign="top" align="center">2.7</td>
<td valign="top" align="center">472</td>
<td valign="top" align="center">10.8</td>
<td valign="top" align="center">567</td>
<td valign="top" align="center">7.2</td>
</tr>
<tr>
<td valign="top" align="left">Exposure to toxic substances, such as dangerous chemicals</td>
<td valign="top" align="center">83</td>
<td valign="top" align="center">2.3</td>
<td valign="top" align="center">361</td>
<td valign="top" align="center">8.3</td>
<td valign="top" align="center">444</td>
<td valign="top" align="center">5.6</td>
</tr>
<tr>
<td valign="top" align="left">Assault with a weapon (being shot, stabbed, or threatened with a knife, or gun)</td>
<td valign="top" align="center">39</td>
<td valign="top" align="center">1.1</td>
<td valign="top" align="center">273</td>
<td valign="top" align="center">6.3</td>
<td valign="top" align="center">312</td>
<td valign="top" align="center">3.9</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TF1"><p>All differences between children (8&#x2013;11 years) and adolescents (12&#x2013;18 years) were statistically significant (<italic>p</italic>&#x2009;&#x003C;&#x2009;0.001).</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s3c"><title>Prevalence of high levels of PTSD symptoms</title>
<p>About one-third (31.4&#x0025;) of children and adolescents exhibited high levels of PTSD symptoms, higher in females than males in the total sample (33.0&#x0025; vs. 29.3&#x0025;, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.003) and adolescents (38.9&#x0025; vs. 31.1&#x0025;, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). Also, rates were higher in adolescents than in children (35.5&#x0025; vs. 24.6&#x0025;, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001), as shown in <xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref>. For children, the prevalence of high PTSD symptoms differed significantly according to nationality and was highest among Syrians living outside camps (30.2&#x0025; vs. 21.5&#x0025; among Jordanians, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). The lowest prevalence was observed among Palestinians living in a camp (20.0&#x0025;). Jordanians and Syrians living in camps had prevalence rates of 21.5&#x0025; and 27.4&#x0025;, respectively. Among adolescents aged 12&#x2013;18 years, no significant differences in PTSD prevalence were observed across nationality groups. The highest prevalence is found among Palestinians living in a camp (37.7&#x0025;), followed by Syrians living in camps (36.4&#x0025;), Jordanians (35.9&#x0025;), and Syrians living outside camps (33.8&#x0025;), without a significant difference (<italic>p</italic>&#x2009;&#x003D;&#x2009;0.531). There was no statistically significant association between nationality and PTSD status in the total sample.</p>
<fig id="F1" position="float"><label>Figure&#x00A0;1</label>
<caption><p>The prevalence of high levels of post-traumatic stress disorder symptoms among children and adolescents by gender and age group. &#x002A; Indicates statistically significant gender difference.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="frcha-04-1648195-g001.tif"><alt-text content-type="machine-generated">Bar chart showing obesity percentages among children and adolescents by gender. For children aged eight to eleven, males are at twenty-six percent, females at twenty-three point six percent, totaling twenty-four point six percent. For adolescents aged twelve to eighteen, males are at thirty-one point one percent, females at thirty-eight point nine percent, totaling thirty-five point five percent. Overall, males and females total twenty-nine point three percent and thirty-three percent, with an overall total of thirty-one point four percent.</alt-text>
</graphic>
</fig>
</sec>
<sec id="s3d"><title>Prevalence of high levels of PTSD according to adverse childhood experiences</title>
<p>The prevalence of high levels of PTSD symptoms among both children and adolescent groups was significantly higher for those who experienced any one of 12 adverse events out of the 18 events studied (<xref ref-type="table" rid="T2">Table&#x00A0;2</xref>).</p>
<table-wrap id="T2" position="float"><label>Table&#x00A0;2</label>
<caption><p>Prevalence of high levels of post-traumatic stress disorder symptoms according to adverse childhood experiences.</p></caption>
<table>
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left" rowspan="3">ACE exposure</th>
<th valign="top" align="center" colspan="8">PTSD</th>
</tr>
<tr>
<th valign="top" align="center" colspan="4">Children (8&#x2013;11 years)<break/><italic>n</italic>&#x2009;&#x003D;&#x2009;3,593</th>
<th valign="top" align="center" colspan="4">Adolescents (12&#x2013;18 years)<break/><italic>n</italic>&#x2009;&#x003D;&#x2009;4,407</th>
</tr>
<tr>
<th valign="top" align="center"><italic>N</italic></th>
<th valign="top" align="center"><italic>n</italic></th>
<th valign="top" align="center">&#x0025;</th>
<th valign="top" align="center"><italic>p</italic>-value</th>
<th valign="top" align="center"><italic>N</italic></th>
<th valign="top" align="center"><italic>n</italic></th>
<th valign="top" align="center">&#x0025;</th>
<th valign="top" align="center"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Natural disasters (floods, intense streams of water, earthquakes)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">2,082</td>
<td valign="top" align="center">506</td>
<td valign="top" align="center">24.3</td>
<td valign="top" align="center" rowspan="2">0.088</td>
<td valign="top" align="center">3,125</td>
<td valign="top" align="center">1,111</td>
<td valign="top" align="center">35.6</td>
<td valign="top" align="center" rowspan="2">0.910</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">90</td>
<td valign="top" align="center">29</td>
<td valign="top" align="center">32.2</td>
<td valign="top" align="center">455</td>
<td valign="top" align="center">163</td>
<td valign="top" align="center">35.8</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Fire or explosion</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,970</td>
<td valign="top" align="center">459</td>
<td valign="top" align="center">23.3</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">2,948</td>
<td valign="top" align="center">991</td>
<td valign="top" align="center">33.6</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">199</td>
<td valign="top" align="center">75</td>
<td valign="top" align="center">37.7</td>
<td valign="top" align="center">638</td>
<td valign="top" align="center">287</td>
<td valign="top" align="center">45.0</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Car accident</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,903</td>
<td valign="top" align="center">461</td>
<td valign="top" align="center">24.2</td>
<td valign="top" align="center" rowspan="2">0.297</td>
<td valign="top" align="center">2,409</td>
<td valign="top" align="center">879</td>
<td valign="top" align="center">36.5</td>
<td valign="top" align="center" rowspan="2">0.116</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">265</td>
<td valign="top" align="center">72</td>
<td valign="top" align="center">27.2</td>
<td valign="top" align="center">1,157</td>
<td valign="top" align="center">391</td>
<td valign="top" align="center">33.8</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Serious accident at home, school, or during recreational activity</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,980</td>
<td valign="top" align="center">471</td>
<td valign="top" align="center">23.8</td>
<td valign="top" align="center" rowspan="2">0.002</td>
<td valign="top" align="center">2,927</td>
<td valign="top" align="center">993</td>
<td valign="top" align="center">33.9</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">195</td>
<td valign="top" align="center">66</td>
<td valign="top" align="center">33.8</td>
<td valign="top" align="center">647</td>
<td valign="top" align="center">283</td>
<td valign="top" align="center">43.7</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Exposure to toxic substances such as dangerous chemicals</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">2,088</td>
<td valign="top" align="center">508</td>
<td valign="top" align="center">24.3</td>
<td valign="top" align="center" rowspan="2">0.475</td>
<td valign="top" align="center">3,216</td>
<td valign="top" align="center">1,139</td>
<td valign="top" align="center">35.4</td>
<td valign="top" align="center" rowspan="2">0.384</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">79</td>
<td valign="top" align="center">22</td>
<td valign="top" align="center">27.8</td>
<td valign="top" align="center">355</td>
<td valign="top" align="center">134</td>
<td valign="top" align="center">37.7</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Physical assault (being attacked, hit, slapped, kicked, beaten up)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,708</td>
<td valign="top" align="center">365</td>
<td valign="top" align="center">21.4</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">2,576</td>
<td valign="top" align="center">809</td>
<td valign="top" align="center">31.4</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">464</td>
<td valign="top" align="center">169</td>
<td valign="top" align="center">36.4</td>
<td valign="top" align="center">984</td>
<td valign="top" align="center">460</td>
<td valign="top" align="center">46.7</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Assault with a weapon (being shot, stabbed, or threatened with a knife, or gun)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">2,134</td>
<td valign="top" align="center">525</td>
<td valign="top" align="center">24.6</td>
<td valign="top" align="center" rowspan="2">0.538</td>
<td valign="top" align="center">3,303</td>
<td valign="top" align="center">1,170</td>
<td valign="top" align="center">35.4</td>
<td valign="top" align="center" rowspan="2">0.266</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">38</td>
<td valign="top" align="center">11</td>
<td valign="top" align="center">28.9</td>
<td valign="top" align="center">268</td>
<td valign="top" align="center">104</td>
<td valign="top" align="center">38.8</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Combat or exposure to a warzone</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,992</td>
<td valign="top" align="center">462</td>
<td valign="top" align="center">23.2</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">3,040</td>
<td valign="top" align="center">1,039</td>
<td valign="top" align="center">34.2</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">180</td>
<td valign="top" align="center">72</td>
<td valign="top" align="center">40.0</td>
<td valign="top" align="center">523</td>
<td valign="top" align="center">230</td>
<td valign="top" align="center">44.0</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Life-threatening illness or injury</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">2,042</td>
<td valign="top" align="center">488</td>
<td valign="top" align="center">23.9</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">3,085</td>
<td valign="top" align="center">1,055</td>
<td valign="top" align="center">34.2</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">122</td>
<td valign="top" align="center">45</td>
<td valign="top" align="center">36.9</td>
<td valign="top" align="center">479</td>
<td valign="top" align="center">210</td>
<td valign="top" align="center">43.8</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">The sudden accidental death of any of the family members</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,672</td>
<td valign="top" align="center">363</td>
<td valign="top" align="center">21.7</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">2,255</td>
<td valign="top" align="center">685</td>
<td valign="top" align="center">30.4</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">489</td>
<td valign="top" align="center">172</td>
<td valign="top" align="center">35.2</td>
<td valign="top" align="center">1,312</td>
<td valign="top" align="center">583</td>
<td valign="top" align="center">44.4</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Infected or a family member infected with COVID-19</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">930</td>
<td valign="top" align="center">246</td>
<td valign="top" align="center">26.5</td>
<td valign="top" align="center" rowspan="2">0.047</td>
<td valign="top" align="center">1,112</td>
<td valign="top" align="center">347</td>
<td valign="top" align="center">31.2</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">1,231</td>
<td valign="top" align="center">280</td>
<td valign="top" align="center">22.7</td>
<td valign="top" align="center">2,449</td>
<td valign="top" align="center">920</td>
<td valign="top" align="center">37.6</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">A family member died from COVID-19</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">2,005</td>
<td valign="top" align="center">479</td>
<td valign="top" align="center">23.9</td>
<td valign="top" align="center" rowspan="2">0.011</td>
<td valign="top" align="center">3,110</td>
<td valign="top" align="center">1,100</td>
<td valign="top" align="center">35.4</td>
<td valign="top" align="center" rowspan="2">0.430</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">158</td>
<td valign="top" align="center">52</td>
<td valign="top" align="center">32.9</td>
<td valign="top" align="center">437</td>
<td valign="top" align="center">163</td>
<td valign="top" align="center">37.3</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Serious injury or harm you caused to someone else</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">2,072</td>
<td valign="top" align="center">504</td>
<td valign="top" align="center">24.3</td>
<td valign="top" align="center" rowspan="2">0.151</td>
<td valign="top" align="center">2,923</td>
<td valign="top" align="center">1,020</td>
<td valign="top" align="center">34.9</td>
<td valign="top" align="center" rowspan="2">0.012</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">94</td>
<td valign="top" align="center">29</td>
<td valign="top" align="center">30.9</td>
<td valign="top" align="center">595</td>
<td valign="top" align="center">240</td>
<td valign="top" align="center">40.3</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Insulted or belittled by a parent or other adult in the house</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,692</td>
<td valign="top" align="center">360</td>
<td valign="top" align="center">21.3</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">2,607</td>
<td valign="top" align="center">774</td>
<td valign="top" align="center">29.7</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">473</td>
<td valign="top" align="center">171</td>
<td valign="top" align="center">36.2</td>
<td valign="top" align="center"/>
<td valign="top" align="center">952</td>
<td valign="top" align="center">502</td>
<td valign="top" align="center">52.7</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Severely beaten by a parent or other adult in the house</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,956</td>
<td valign="top" align="center">441</td>
<td valign="top" align="center">22.5</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">2,863</td>
<td valign="top" align="center">936</td>
<td valign="top" align="center">32.7</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">216</td>
<td valign="top" align="center">94</td>
<td valign="top" align="center">43.5</td>
<td valign="top" align="center">682</td>
<td valign="top" align="center">333</td>
<td valign="top" align="center">48.8</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Feeling that no one in your family loves you</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,884</td>
<td valign="top" align="center">406</td>
<td valign="top" align="center">21.5</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">2,630</td>
<td valign="top" align="center">777</td>
<td valign="top" align="center">29.5</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">279</td>
<td valign="top" align="center">124</td>
<td valign="top" align="center">44.4</td>
<td valign="top" align="center">932</td>
<td valign="top" align="center">499</td>
<td valign="top" align="center">53.5</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Did not have enough to eat, or had to wear old clothes</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,455</td>
<td valign="top" align="center">281</td>
<td valign="top" align="center">19.3</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">2,933</td>
<td valign="top" align="center">966</td>
<td valign="top" align="center">32.9</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">708</td>
<td valign="top" align="center">252</td>
<td valign="top" align="center">35.6</td>
<td valign="top" align="center">635</td>
<td valign="top" align="center">310</td>
<td valign="top" align="center">48.8</td>
</tr>
<tr>
<td valign="top" align="left" style="background-color:#d9d9d9" colspan="9">Failing an exam</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;No</td>
<td valign="top" align="center">1,486</td>
<td valign="top" align="center">318</td>
<td valign="top" align="center">21.4</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
<td valign="top" align="center">1,802</td>
<td valign="top" align="center">567</td>
<td valign="top" align="center">31.5</td>
<td valign="top" align="center" rowspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Yes</td>
<td valign="top" align="center">686</td>
<td valign="top" align="center">218</td>
<td valign="top" align="center">31.8</td>
<td valign="top" align="center">1,777</td>
<td valign="top" align="center">714</td>
<td valign="top" align="center">40.2</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="s3e"><title>Multivariate analysis of the association between PTSD and adverse childhood experiences</title>
<p>For both children and adolescents, the child/adolescent&#x0027;s feeling of not being beloved by the family was significantly associated with the highest odds of PTSD (OR&#x2009;&#x003D;&#x2009;2.1, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). For both age groups, the following ACEs were significantly associated with increased odds of high PTSD symptom levels: the sudden accidental death of any of the family members (OR&#x2009;&#x003D;&#x2009;1.9 for children and 1.8 for adolescents, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001), not having enough to eat, or having to wear old clothes (OR&#x2009;&#x003D;&#x2009;1.7, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). Additionally, failing an exam was associated with high PTSD symptoms in children only (OR&#x2009;&#x003D;&#x2009;1.5, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001), while experiencing physical assault (OR&#x2009;&#x003D;&#x2009;1.4, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.002), being infected or a family member infected with COVID-19 (OR&#x2009;&#x003D;&#x2009;1.3, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.001), a serious accident at home, or school or during recreational activity (OR&#x2009;&#x003D;&#x2009;1.3, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.021), and being Insulted or belittled by a parent or other adult in the house (OR&#x2009;&#x003D;&#x2009;1.6, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001) was associated with increased odds of high PTSD symptoms in adolescents only, as shown in <xref ref-type="table" rid="T3">Table&#x00A0;3</xref>.</p>
<table-wrap id="T3" position="float"><label>Table&#x00A0;3</label>
<caption><p>Multivariate analysis of the association between high post-traumatic stress disorder symptom levels and adverse childhood experiences&#x002A;.</p></caption>
<table>
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left" rowspan="3">Event</th>
<th valign="top" align="center" colspan="8">High PTSD symptoms</th>
</tr>
<tr>
<th valign="top" align="center" colspan="4">Children (8&#x2013;11 years)<break/><italic>n</italic>&#x2009;&#x003D;&#x2009;3,593</th>
<th valign="top" align="center" colspan="4">Adolescents (12&#x2013;18 years)<break/><italic>n</italic>&#x2009;&#x003D;&#x2009;4,407</th>
</tr>
<tr>
<th valign="top" align="center">OR</th>
<th valign="top" align="center" colspan="2">95&#x0025; confidence interval</th>
<th valign="top" align="center"><italic>p</italic>-value</th>
<th valign="top" align="center">OR</th>
<th valign="top" align="center" colspan="2">95&#x0025; confidence interval</th>
<th valign="top" align="center"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Feeling that no one in your family loves you</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">2.9</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">1.7</td>
<td valign="top" align="center">2.6</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">The sudden accidental death of any of the family members</td>
<td valign="top" align="center">1.9</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">2.5</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">1.8</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">Did not have enough to eat, or had to wear old clothes</td>
<td valign="top" align="center">1.7</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">2.2</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">1.7</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">Physical assault (being attacked, hit, slapped, kicked, beaten up)</td>
<td valign="top" align="center">1.3</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">1.8</td>
<td valign="top" align="center">0.043</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">1.1</td>
<td valign="top" align="center">1.6</td>
<td valign="top" align="center">0.002</td>
</tr>
<tr>
<td valign="top" align="left">Failing an exam</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">1.9</td>
<td valign="top" align="center">0.001</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">0.056</td>
</tr>
<tr>
<td valign="top" align="left">Assault with a weapon (being shot, stabbed, or threatened with a knife, or gun)</td>
<td valign="top" align="center">0.3</td>
<td valign="top" align="center">0.1</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.013</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.6</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.339</td>
</tr>
<tr>
<td valign="top" align="left">Infected or a family member infected with COVID-19</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.712</td>
<td valign="top" align="center">1.3</td>
<td valign="top" align="center">1.1</td>
<td valign="top" align="center">1.6</td>
<td valign="top" align="center">0.001</td>
</tr>
<tr>
<td valign="top" align="left">Serious accidents at home, school, or during recreational activity</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">1.8</td>
<td valign="top" align="center">0.364</td>
<td valign="top" align="center">1.3</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">1.6</td>
<td valign="top" align="center">0.021</td>
</tr>
<tr>
<td valign="top" align="left">Car Accident</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">0.911</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">0.018</td>
</tr>
<tr>
<td valign="top" align="left">Insulted or belittled by a parent or other adult in the house</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">1.6</td>
<td valign="top" align="center">0.346</td>
<td valign="top" align="center">1.6</td>
<td valign="top" align="center">1.3</td>
<td valign="top" align="center">2.0</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">Exposure to toxic substances, such as dangerous chemicals</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">0.4</td>
<td valign="top" align="center">1.7</td>
<td valign="top" align="center">0.682</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">0.6</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.301</td>
</tr>
<tr>
<td valign="top" align="left">Natural disasters (floods, intense streams of water, earthquakes)</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.4</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">0.323</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.382</td>
</tr>
<tr>
<td valign="top" align="left">Fire or explosion</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">0.087</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">0.052</td>
</tr>
<tr>
<td valign="top" align="left">Combat or exposure to a warzone</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">0.070</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">1.6</td>
<td valign="top" align="center">0.123</td>
</tr>
<tr>
<td valign="top" align="left">Life-threatening illness or injury</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">2.2</td>
<td valign="top" align="center">0.185</td>
<td valign="top" align="center">1.2</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">0.207</td>
</tr>
<tr>
<td valign="top" align="left">A family member died from COVID-19</td>
<td valign="top" align="center">1.1</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">1.6</td>
<td valign="top" align="center">0.804</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.6</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">0.052</td>
</tr>
<tr>
<td valign="top" align="left">Serious injury or harm you caused to someone else</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">0.4</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">0.494</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">1.1</td>
<td valign="top" align="center">0.319</td>
</tr>
<tr>
<td valign="top" align="left">Severely beaten by a parent or other adult in the house</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">0.064</td>
<td valign="top" align="center">1.1</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">0.298</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TF2"><p>&#x002A;Adjusted for gender and having chronic illnesses. The value of Nagelkerke R Square is 14.0&#x0025; for children and 18.0&#x0025; for adolescents.</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s3f"><title>Number of ACE and PTSD symptoms</title>
<p>Across the sample, differences in the number of ACEs were more pronounced among children, with higher ACE counts more frequently reported among Syrian children, especially those living outside camps. In contrast, these disparities became less marked in the adolescent group, where the proportions of ACE exposure were more comparable across nationalities. Among children, significant differences in ACE exposure numbers were identified across nationalities (<italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). For 0 ACEs, Syrians living in camps had a significantly higher proportion than Jordanians (34.6&#x0025; vs. 24.6&#x0025;, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001), and Syrians living outside camps (34.6&#x0025; vs. 26.7&#x0025;, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.010). For 1 ACE, Jordanians had a significantly higher observed proportion compared with Syrians living outside camps (29.8&#x0025; vs. 22.1&#x0025;, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.001). However, for the 4 or more ACEs, Syrians living outside camps had a significantly higher proportion than both Jordanians (20.9&#x0025; vs. 15.3&#x0025;, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.002) and Syrians living in camps (20.9&#x0025; vs. 14.5&#x0025;, <italic>p</italic>&#x2009;&#x003D;&#x2009;0.018). Among adolescents, although the overall chi-square test was statistically significant, the proportions across most ACE categories were largely comparable across nationalities. The only significant difference appeared in the no ACEs category, where Syrians living in camps had a significantly higher proportion compared with Jordanian adolescents (17.9&#x0025; vs. 11.1&#x0025;, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001) and those of other nationalities.</p>
<p>An increased number of ACEs was significantly associated with higher odds of PTSD symptoms after adjusting for gender and chronic medical conditions. Experiencing four or more ACEs was linked to significantly increased odds of PTSD in children (OR&#x2009;&#x003D;&#x2009;5.0, 95&#x0025; CI: 3.7&#x2013;6.7, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001) and adolescents (OR&#x2009;&#x003D;&#x2009;4.3, 95&#x0025; CI: 3.4&#x2013;5.5, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001) (<xref ref-type="table" rid="T4">Table&#x00A0;4</xref>).</p>
<table-wrap id="T4" position="float"><label>Table&#x00A0;4</label>
<caption><p>The association between the number of adverse childhood experiences and high post-traumatic stress disorder symptom levels.</p></caption>
<table>
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left" rowspan="3">Number of events</th>
<th valign="top" align="center" colspan="8">High PTSD symptoms</th>
</tr>
<tr>
<th valign="top" align="center" colspan="4">Children (8&#x2013;11 years)</th>
<th valign="top" align="center" colspan="4">Adolescents (12&#x2013;18 years)</th>
</tr>
<tr>
<th valign="top" align="center">OR</th>
<th valign="top" align="center" colspan="2">95&#x0025; confidence interval</th>
<th valign="top" align="center"><italic>P</italic>-value</th>
<th valign="top" align="center">OR</th>
<th valign="top" align="center" colspan="2">95&#x0025; confidence interval</th>
<th valign="top" align="center"><italic>P</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">1</td>
<td valign="top" align="center">1</td>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
<td valign="top" align="center">1</td>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left">2</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">1.5</td>
<td valign="top" align="center">2.8</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">1.4</td>
<td valign="top" align="center">1.0</td>
<td valign="top" align="center">1.9</td>
<td valign="top" align="center">0.022</td>
</tr>
<tr>
<td valign="top" align="left">3</td>
<td valign="top" align="center">2.9</td>
<td valign="top" align="center">2.1</td>
<td valign="top" align="center">4.0</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">2.4</td>
<td valign="top" align="center">1.8</td>
<td valign="top" align="center">3.1</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">&#x2265;4</td>
<td valign="top" align="center">5.0</td>
<td valign="top" align="center">3.7</td>
<td valign="top" align="center">6.7</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">4.3</td>
<td valign="top" align="center">3.4</td>
<td valign="top" align="center">5.5</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TF3"><p>Adjusted for gender and having chronic illnesses.</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec id="s4" sec-type="discussion"><title>Discussion</title>
<p>High rates of PTSD symptoms among children and adolescents in Jordan were found. Studies in Jordan reveal varying prevalence rates of PTSD between 16.2&#x0025; and 65.1&#x0025; (<xref ref-type="bibr" rid="B16">16</xref>), likely due to differences in trauma type, population studied, and methodologies. Despite these differences, findings highlight an alarmingly high prevalence, particularly among females and refugees (<xref ref-type="bibr" rid="B25">25</xref>&#x2013;<xref ref-type="bibr" rid="B27">27</xref>). PTSD symptoms were higher in adolescents, likely due to the unique characteristics of this developmental stage, with being particularly susceptible to experiencing multiple types of ACEs (<xref ref-type="bibr" rid="B28">28</xref>, <xref ref-type="bibr" rid="B29">29</xref>). Adolescence involves biopsychosocial changes, such as evolving relationships and increased reliance on peers, which may lead to risky behaviors and traumatic events, contributing to PTSD vulnerability (<xref ref-type="bibr" rid="B30">30</xref>).</p>
<p>The higher rates of PTSD symptom levels in adolescent females than males were consistent with other studies (<xref ref-type="bibr" rid="B31">31</xref>, <xref ref-type="bibr" rid="B32">32</xref>). These rates could be explained from different perspectives. Societal norms may encourage females to express emotions, possibly leading to higher reported PTSD rates, while males may underreport. Psychologically, females have a higher tendency for rumination and dwelling on distressing thoughts and feelings, which can exacerbate PTSD symptoms and make females more likely to express greater levels of stress and often internalize traumatic events, contributing to the higher incidence of anxiety, depression, and consequently PTSD. Biologically, hormonal factors like estrogen and differences in brain structures regulating emotions and memory may contribute to this susceptibility (<xref ref-type="bibr" rid="B33">33</xref>&#x2013;<xref ref-type="bibr" rid="B36">36</xref>). Another explanation may be that female children and adolescents are at higher risk of certain types of abuse, particularly emotional abuse and psychological maltreatment (<xref ref-type="bibr" rid="B37">37</xref>) and female youth exposed to violence exhibit higher trauma symptoms, including PTSD-related symptoms (<xref ref-type="bibr" rid="B38">38</xref>).</p>
<p>Children feeling emotionally disregarded by their families had the highest odds of PTSD, consistent with attachment theory. Secure attachment is essential for healthy development, and feelings of neglect can lead to emotional dysregulation and increased PTSD risk (<xref ref-type="bibr" rid="B39">39</xref>). Children who feel unloved or emotionally disregarded by their family members often lack sufficient emotional support and guidance in managing stress, impeding their ability to develop effective coping mechanisms, and making them more prone to developing PTSD when exposed to trauma (<xref ref-type="bibr" rid="B40">40</xref>&#x2013;<xref ref-type="bibr" rid="B42">42</xref>). Also, the perception of being unloved or unsupported can intensify feelings of isolation and helplessness, which are critical factors in the development of PTSD. Social support is a well-documented protective factor against PTSD, and the absence of perceived familial support significantly increases PTSD risk (<xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B44">44</xref>). Findings showed that the sudden accidental death of a family member significantly increased the likelihood of developing PTSD. The sudden and unexpected nature of deaths leaves children particularly vulnerable to PTSD due to the sense of shock and disruption, along with a lack of preparation for the loss (<xref ref-type="bibr" rid="B45">45</xref>&#x2013;<xref ref-type="bibr" rid="B47">47</xref>). Studies emphasize the importance of timely and effective psychological interventions to support bereaved young children and adolescents, along with providing targeted mental health care and fostering resilient coping mechanisms (<xref ref-type="bibr" rid="B45">45</xref>&#x2013;<xref ref-type="bibr" rid="B47">47</xref>). The higher odds of PTSD in children or adolescents who experience food insecurity and have to wear old clothes suggest a possible association with SES (<xref ref-type="bibr" rid="B48">48</xref>).</p>
<p>Exam failure was strongly linked to elevated PTSD symptoms in children. Children encounter significant pressure to perform academically, and failing an exam can be viewed as a major threat to their social standing and self-esteem (<xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B49">49</xref>, <xref ref-type="bibr" rid="B50">50</xref>). Unlike adults, coping strategies for children may be inadequately developed to manage such setbacks, making them especially susceptible to stress responses (<xref ref-type="bibr" rid="B49">49</xref>). Research indicates that children commonly display intense emotional reactions to academic failures, including shame, fear of punishment, and anxiety about future academic performance (<xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B49">49</xref>, <xref ref-type="bibr" rid="B50">50</xref>). COVID-19 infection emerged as the most reported ACE, with stressors like school closures, isolation, and misinformation contributing to PTSD symptoms (<xref ref-type="bibr" rid="B51">51</xref>) with findings in line with other studies, highlighting the adverse effects of social isolation and disrupted routines during this pandemic (<xref ref-type="bibr" rid="B52">52</xref>, <xref ref-type="bibr" rid="B53">53</xref>).</p>
<p>Research consistently demonstrates that psychological abuse by parents are significantly related to mental health problems in adolescents (<xref ref-type="bibr" rid="B54">54</xref>), including PTSD (<xref ref-type="bibr" rid="B55">55</xref>) and to extending effects as poor performance in school (<xref ref-type="bibr" rid="B56">56</xref>). The long-term effects of severe parental abuse have also been emphasized in the literature, with American psychiatrists studied 156 children who had experienced severe parental abuse and found that 62 (40&#x0025;) met the diagnostic criteria for PTSD, with 33&#x0025; continuing to meet the criteria even after two years (<xref ref-type="bibr" rid="B57">57</xref>). Moreover, PTSD in these children was associated with internalizing disorders such as anxiety and depression (<xref ref-type="bibr" rid="B57">57</xref>).</p>
<p>An increased number of ACE was significantly associated with increased odds of having high PTSD symptoms, in line with the results of previous studies (<xref ref-type="bibr" rid="B58">58</xref>&#x2013;<xref ref-type="bibr" rid="B60">60</xref>), which can be explained by various interrelated factors. First, the accumulation of stress overwhelms the development of cognitive and emotional systems among children and adolescents (<xref ref-type="bibr" rid="B60">60</xref>). Multiple traumatic experiences increase the psychological burden, which impairs the ability to process and manage stress. Second, exposure to multiple ACEs can adversely impact crucial developmental processes, such as emotional regulation, self-concept, and forming secure attachments (<xref ref-type="bibr" rid="B61">61</xref>). These disruptions may reduce children&#x0027;s ability to develop resilience and healthy coping mechanisms, which ultimately increases the odds of high PTSD symptoms (<xref ref-type="bibr" rid="B61">61</xref>, <xref ref-type="bibr" rid="B62">62</xref>). Last, each additional traumatic event can intensify or exacerbate the psychological effect of previous traumas (<xref ref-type="bibr" rid="B62">62</xref>, <xref ref-type="bibr" rid="B63">63</xref>). A comprehensive approach tailored to the specific needs of adolescents is therefore needed and healthcare professionals should focus on assessing the full spectrum of traumatic experiences, rather than concentrating solely on the most prominent events.</p>
</sec>
<sec id="s5"><title>Policy implications</title>
<p>The high prevalence of PTSD and ACEs among children in Jordan requires urgent attention. Evidence-based interventions to prevent ACE and reduce its impact encompass a range of approaches, including community-wide interventions, parenting programs, home visits, economic and social service interventions, psychological therapies, and school-based programs (<xref ref-type="bibr" rid="B64">64</xref>). In Jordan, school-based programs emerge as a suitable option due to the limited accessibility and societal acceptance of psychological therapies, which also applies to other interventions such as parenting programs and home visits. Additionally, school-based programs are supported by evidence for cost-effectiveness (<xref ref-type="bibr" rid="B65">65</xref>).</p>
<p>Interventions should adopt a holistic approach that acknowledges the cumulative and collective burden of multiple ACEs, rather than addressing them as isolated events, along with accounting for the broader socioeconomic and environmental factors contributing to adverse experiences (<xref ref-type="bibr" rid="B66">66</xref>). The root causes of ACEs extend beyond parenting practices and are also linked to socioeconomic disparities and systemic inequalities. For example, the education ban on females in Afghanistan was found to correlate with a wide range of negative mental health outcomes among females (<xref ref-type="bibr" rid="B67">67</xref>). This highlights the necessity of strong social welfare programs, mental health support systems, and other components to create a protective environment that mitigates childhood trauma in a multi-layered approach.</p>
</sec>
<sec id="s6"><title>Limitations</title>
<p>One limitation of this study is its cross-sectional design, which identifies correlations but does not establish causal relationships. Another limitation is the potential for underreporting bias, particularly in sensitive mental health-related topics such as childhood experience. Sensitive issues such as emotional abuse and neglect may be especially susceptible to underreporting, particularly in cultural contexts where stigma, limited awareness, or the tendency to present a socially desirable family image influence response. This potential underreporting may contribute to the underestimation of both the prevalence of ACE and its impact on PTSD symptom levels.</p>
<p>Future research would benefit from employing longitudinal designs to assess the impact of ACEs on mental health outcomes, including PTSD, with stronger causal evidence. Additionally, further studies are encouraged to focus on developing and evaluating intervention programs to determine their effectiveness in addressing ACEs and PTSD.</p>
</sec>
<sec id="s7" sec-type="conclusions"><title>Conclusion</title>
<p>The findings highlight a high prevalence of PTSD among children and adolescents exposed to ACEs, with multiple ACEs being associated with high levels of PTSD symptoms and a cumulative pattern of ACEs further increasing the likelihood of experiencing high PTSD symptoms levels. These results underscore the need for targeted interventions that address key ACEs in specific age groups and the development of holistic and comprehensive prevention programs that integrate support for parents, families, schools, communities, and broader societal contexts. In addition, interventions should be designed to mitigate the cumulative and collective effects of multiple ACEs and address different ACEs simultaneously rather than in isolation.</p>
</sec>
</body>
<back>
<sec id="s8" sec-type="data-availability"><title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="s9" sec-type="ethics-statement"><title>Ethics statement</title>
<p>This survey followed the &#x201C;Declaration of Helsinki&#x201D; and other relevant local ethical guidelines for medical and health research involving human subjects. Participants and their caregivers were fully informed by the document explaining the details of the study purpose, methods, ethical considerations, the voluntariness of their participation, and that they could withdraw at any time without explanation. All participants were informed that if participation causes any stress or discomfort, they can withdraw from the study without any ensuing penalties or conditions. Ethical approvals were obtained from the Institutional Research Committees at Jordan University of Science and Technology (Ref. 11/151/2022), and Jordan Ministry of Health (Ref. MBA/16289). Written informed consent was obtained from self-reporting adolescents, while consent for children was obtained from their legal guardians/next of kin.</p>
</sec>
<sec id="s10" sec-type="author-contributions"><title>Author contributions</title>
<p>SAK: Methodology, Investigation, Data curation, Formal analysis, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. YK: Conceptualization, Methodology, Investigation, Data curation, Formal analysis, Project administration, Resources, Software, Supervision, Validation, Visualization, Funding acquisition, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. OAK: Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. MAN: Project administration, Funding acquisition, Resources, Writing &#x2013; review &#x0026; editing. ET: Methodology, Project administration, Validation, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec id="s12" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s13" sec-type="ai-statement"><title>Generative AI statement</title>
<p>The author(s) declared that generative AI was not used in the creation of this manuscript.</p>
<p>Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.</p>
</sec>
<sec id="s14" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<ref-list><title>References</title>
<ref id="B1"><label>1.</label><mixed-citation publication-type="other"><collab>CDC</collab>. <comment>About Adverse Childhood Experiences &#x007C; Adverse Childhood Experiences (ACEs) 2024. Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/aces/about/index.html">https://www.cdc.gov/aces/about/index.html</ext-link> <comment>(Accessed October 20, 2024)</comment></mixed-citation></ref>
<ref id="B2"><label>2.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Merrick</surname> <given-names>MT</given-names></name> <name><surname>Ford</surname> <given-names>DC</given-names></name> <name><surname>Ports</surname> <given-names>KA</given-names></name> <name><surname>Guinn</surname> <given-names>AS</given-names></name> <name><surname>Chen</surname> <given-names>J</given-names></name> <name><surname>Klevens</surname> <given-names>J</given-names></name><etal/></person-group> <article-title>Vital signs: estimated proportion of adult health problems attributable to adverse childhood experiences and implications for prevention &#x2014; 25 states, 2015&#x2013;2017</article-title>. <source>Morb Mortal Wkly Rep</source>. (<year>2019</year>) <volume>68</volume>:<fpage>999</fpage>. <pub-id pub-id-type="doi">10.15585/MMWR.MM6844E1</pub-id></mixed-citation></ref>
<ref id="B3"><label>3.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murphy</surname> <given-names>S</given-names></name> <name><surname>Shevlin</surname> <given-names>M</given-names></name> <name><surname>Armour</surname> <given-names>C</given-names></name> <name><surname>Elklit</surname> <given-names>A</given-names></name> <name><surname>Christoffersen</surname> <given-names>MN</given-names></name></person-group>. <article-title>Childhood adversity and PTSD experiences: testing a multiple mediator model</article-title>. <source>Traumatology (Tallahass Fla)</source>. (<year>2014</year>) <volume>20</volume>:<fpage>225</fpage>&#x2013;<lpage>31</lpage>. <pub-id pub-id-type="doi">10.1037/H0099838</pub-id></mixed-citation></ref>
<ref id="B4"><label>4.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vranceanu</surname> <given-names>AM</given-names></name> <name><surname>Hobfoll</surname> <given-names>SE</given-names></name> <name><surname>Johnson</surname> <given-names>RJ</given-names></name></person-group>. <article-title>Child multi-type maltreatment and associated depression and PTSD symptoms: the role of social support and stress</article-title>. <source>Child Abuse Negl</source>. (<year>2007</year>) <volume>31</volume>:<fpage>71</fpage>&#x2013;<lpage>84</lpage>. <pub-id pub-id-type="doi">10.1016/J.CHIABU.2006.04.010</pub-id><pub-id pub-id-type="pmid">17215039</pub-id></mixed-citation></ref>
<ref id="B5"><label>5.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wa Mwenda Jonas</surname> <given-names>KA</given-names></name> <name><surname>Kisungu Basile</surname> <given-names>K</given-names></name> <name><surname>Jean Baptiste</surname> <given-names>K</given-names></name></person-group>. <article-title>Associations between posttraumatic stress symptoms and abuse experiences in child and adolescent girls from a central African country</article-title>. <source>J Trauma Stress</source>. (<year>2022</year>) <volume>35</volume>:<fpage>1432</fpage>&#x2013;<lpage>44</lpage>. <pub-id pub-id-type="doi">10.1002/jts.22843</pub-id><pub-id pub-id-type="pmid">35642389</pub-id></mixed-citation></ref>
<ref id="B6"><label>6.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Shah</surname> <given-names>A</given-names></name> <name><surname>Banner</surname> <given-names>N</given-names></name> <name><surname>Heginbotham</surname> <given-names>C</given-names></name> <name><surname>Fulford</surname> <given-names>B</given-names></name></person-group>. <source>7. American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders</source>. <edition>5th ed.</edition> <publisher-loc>Arlington</publisher-loc>: <publisher-name>American Psychiatric Publishing</publisher-name> (<year>2014</year>).</mixed-citation></ref>
<ref id="B7"><label>7.</label><mixed-citation publication-type="other"><collab>National Center for PTSD</collab>. <comment>PTSD in Children and Adolescents 2022. Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.ptsd.va.gov/professional/treat/specific/ptsd_child_teens.asp#four">https://www.ptsd.va.gov/professional/treat/specific/ptsd_child_teens.asp&#x0023;four</ext-link> <comment>(Accessed December 22, 2025)</comment>.</mixed-citation></ref>
<ref id="B8"><label>8.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname> <given-names>B</given-names></name> <name><surname>Yuan</surname> <given-names>H</given-names></name> <name><surname>Wu</surname> <given-names>X</given-names></name> <name><surname>Wang</surname> <given-names>W</given-names></name></person-group>. <article-title>Comorbidity patterns of posttraumatic stress disorder and depression symptoms: cross-validation in two post-earthquake child and adolescent samples</article-title>. <source>Depress Anxiety</source>. (<year>2023</year>) <volume>2023</volume>:<fpage>4453663</fpage>. <pub-id pub-id-type="doi">10.1155/2023/4453663</pub-id><pub-id pub-id-type="pmid">40224591</pub-id></mixed-citation></ref>
<ref id="B9"><label>9.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Krantz</surname> <given-names>DS</given-names></name> <name><surname>Shank</surname> <given-names>LM</given-names></name> <name><surname>Goodie</surname> <given-names>JL</given-names></name></person-group>. <article-title>Post-traumatic stress disorder (PTSD) as a systemic disorder: pathways to cardiovascular disease</article-title>. <source>Health Psychol</source>. (<year>2022</year>) <volume>41</volume>:<fpage>651</fpage>&#x2013;<lpage>62</lpage>. <pub-id pub-id-type="doi">10.1037/hea0001127</pub-id><pub-id pub-id-type="pmid">34807673</pub-id></mixed-citation></ref>
<ref id="B10"><label>10.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Coughlin</surname> <given-names>SS</given-names></name></person-group>. <article-title>Post-traumatic stress disorder and cardiovascular disease</article-title>. <source>Open Cardiovasc Med J</source>. (<year>2011</year>) <volume>5</volume>:<fpage>164</fpage>. <pub-id pub-id-type="doi">10.2174/1874192401105010164</pub-id><pub-id pub-id-type="pmid">21792377</pub-id></mixed-citation></ref>
<ref id="B11"><label>11.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khader</surname> <given-names>Y</given-names></name> <name><surname>Abu Khudair</surname> <given-names>S</given-names></name> <name><surname>Tanaka</surname> <given-names>E</given-names></name> <name><surname>Kufoof</surname> <given-names>L</given-names></name> <name><surname>Al Nsour</surname> <given-names>M</given-names></name> <name><surname>Aqel</surname> <given-names>A</given-names></name><etal/></person-group> <article-title>Psychosocial, emotional and behavioral problems, quality of life, and mental health care seeking behaviors among children and adolescents in Jordan: a national school-based survey</article-title>. <source>Front Public Health</source>. (<year>2024</year>) <volume>12</volume>:<fpage>1409158</fpage>. <pub-id pub-id-type="doi">10.3389/FPUBH.2024.1409158</pub-id><pub-id pub-id-type="pmid">39600408</pub-id></mixed-citation></ref>
<ref id="B12"><label>12.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Betawi</surname> <given-names>IA</given-names></name></person-group>. <article-title>Away from home: psychological well-being of Syrian children at Azraq refugee camp in Jordan</article-title>. <source>Early Child Dev Care</source>. (<year>2019</year>) <volume>189</volume>:<fpage>846</fpage>&#x2013;<lpage>54</lpage>. <pub-id pub-id-type="doi">10.1080/03004430.2017.1345895</pub-id></mixed-citation></ref>
<ref id="B13"><label>13.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Al Khatib</surname> <given-names>AJ</given-names></name></person-group>. <article-title>A comprehensive review of research on child abuse in Jordan</article-title>. <source>Child Care in Practice</source>. (<year>2022</year>) <volume>28</volume>:<fpage>125</fpage>&#x2013;<lpage>36</lpage>. <pub-id pub-id-type="doi">10.1080/13575279.2020.1765144</pub-id></mixed-citation></ref>
<ref id="B14"><label>14.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carlson</surname> <given-names>JS</given-names></name> <name><surname>Yohannan</surname> <given-names>J</given-names></name> <name><surname>Darr</surname> <given-names>CL</given-names></name> <name><surname>Turley</surname> <given-names>MR</given-names></name> <name><surname>Larez</surname> <given-names>NA</given-names></name> <name><surname>Perfect</surname> <given-names>MM</given-names></name></person-group>. <article-title>Prevalence of adverse childhood experiences in school-aged youth: a systematic review (1990&#x2013;2015)</article-title>. <source>Int J Sch Educ Psychol</source>. (<year>2020</year>) <volume>8</volume>:<fpage>2</fpage>&#x2013;<lpage>23</lpage>. <pub-id pub-id-type="doi">10.1080/21683603.2018.1548397</pub-id></mixed-citation></ref>
<ref id="B15"><label>15.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alisic</surname> <given-names>E</given-names></name> <name><surname>Zalta</surname> <given-names>AK</given-names></name> <name><surname>Van Wesel</surname> <given-names>F</given-names></name> <name><surname>Larsen</surname> <given-names>SE</given-names></name> <name><surname>Hafstad</surname> <given-names>GS</given-names></name> <name><surname>Hassanpour</surname> <given-names>K</given-names></name><etal/></person-group> <article-title>Rates of post-traumatic stress disorder in trauma-exposed children and adolescents: meta-analysis</article-title>. <source>Br J Psychiatry</source>. (<year>2014</year>) <volume>204</volume>:<fpage>335</fpage>&#x2013;<lpage>40</lpage>. <pub-id pub-id-type="doi">10.1192/bjp.bp.113.131227</pub-id><pub-id pub-id-type="pmid">24785767</pub-id></mixed-citation></ref>
<ref id="B16"><label>16.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>AlHamawi</surname> <given-names>R</given-names></name> <name><surname>Khader</surname> <given-names>Y</given-names></name> <name><surname>Abu Khudair</surname> <given-names>S</given-names></name> <name><surname>Tanaka</surname> <given-names>E</given-names></name> <name><surname>Al Nsour</surname> <given-names>M</given-names></name></person-group>. <article-title>Mental health and psychosocial problems among children and adolescents in Jordan: a scoping review</article-title>. <source>Children</source>. (<year>2023</year>) <volume>10</volume>:<fpage>1165</fpage>. <pub-id pub-id-type="doi">10.3390/children10071165</pub-id><pub-id pub-id-type="pmid">37508662</pub-id></mixed-citation></ref>
<ref id="B17"><label>17.</label><mixed-citation publication-type="other"><comment>Jordan &#x007C; UNHCR</comment>. (<year>n.d.</year>). <comment>Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.unhcr.org/where-we-work/countries/jordan?dataset=POP%26yearsMode=range%26selectedYears=%5B2012%2C2026%5D%26level=OPR%26category=PTY%26fundingSource=ALS%26compareBy=%5B%22category%22%5D%26levelCompare=%5B%5B%22OJOR_ABC%22%5D%5D%26viewType=chart%26chartType=bar%26contextualDataset=BUD%26tableDataView=absolute">https://www.unhcr.org/where-we-work/countries/jordan?dataset&#x003D;POP&#x0026;yearsMode&#x003D;range&#x0026;selectedYears&#x003D;&#x0025;5B2012&#x0025;2C2026&#x0025;5D&#x0026;level&#x003D;OPR&#x0026;category&#x003D;PTY&#x0026;fundingSource&#x003D;ALS&#x0026;compareBy&#x003D;&#x0025;5B&#x0025;22category&#x0025;22&#x0025;5D&#x0026;levelCompare&#x003D;&#x0025;5B&#x0025;5B&#x0025;22OJOR_ABC&#x0025;22&#x0025;5D&#x0025;5D&#x0026;viewType&#x003D;chart&#x0026;chartType&#x003D;bar&#x0026;contextualDataset&#x003D;BUD&#x0026;tableDataView&#x003D;absolute</ext-link> <comment>(Accessed November 29, 2025)</comment></mixed-citation></ref>
<ref id="B18"><label>18.</label><mixed-citation publication-type="other"><comment>Jordan &#x2013; Recent Demographic Indicators (April 2024) &#x007C; HPC</comment>. (<year>n.d.</year>). <comment>Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.hpc.org.jo/en/content/jordan-%E2%80%93-recent-demographic-indicators-april-2024">https://www.hpc.org.jo/en/content/jordan-&#x0025;E2&#x0025;80&#x0025;93-recent-demographic-indicators-april-2024</ext-link> <comment>(Accessed November 29, 2025)</comment></mixed-citation></ref>
<ref id="B19"><label>19.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dehnel</surname> <given-names>R</given-names></name> <name><surname>Dalky</surname> <given-names>H</given-names></name> <name><surname>Sudarsan</surname> <given-names>S</given-names></name> <name><surname>Al-Delaimy</surname> <given-names>WK</given-names></name></person-group>. <article-title>Resilience and mental health among Syrian refugee children in Jordan</article-title>. <source>J Immigr Minor Health</source>. (<year>2021</year>) <volume>24</volume>:<fpage>420</fpage>. <pub-id pub-id-type="doi">10.1007/S10903-021-01180-0</pub-id><pub-id pub-id-type="pmid">33900548</pub-id></mixed-citation></ref>
<ref id="B20"><label>20.</label><mixed-citation publication-type="other"><comment>&#x201C;We&#x2019;re Afraid for Their Future&#x201D;: Barriers to Education for Syrian Refugee Children in Jordan &#x007C; HRW</comment>. (<year>n.d.</year>). <comment>Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.hrw.org/report/2016/08/16/were-afraid-their-future/barriers-education-syrian-refugee-children-jordan">https://www.hrw.org/report/2016/08/16/were-afraid-their-future/barriers-education-syrian-refugee-children-jordan</ext-link> <comment>(Accessed November 29, 2025)</comment></mixed-citation></ref>
<ref id="B21"><label>21.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Felitti</surname> <given-names>VJ</given-names></name> <name><surname>Anda</surname> <given-names>RF</given-names></name> <name><surname>Nordenberg</surname> <given-names>D</given-names></name> <name><surname>Williamson</surname> <given-names>DF</given-names></name> <name><surname>Spitz</surname> <given-names>AM</given-names></name> <name><surname>Edwards</surname> <given-names>V</given-names></name><etal/></person-group> <article-title>Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults</article-title>. <source>Am J Prev Med</source>. (<year>1998</year>) <volume>14</volume>:<fpage>245</fpage>&#x2013;<lpage>58</lpage>. <pub-id pub-id-type="doi">10.1016/S0749-3797(98)00017-8</pub-id><pub-id pub-id-type="pmid">9635069</pub-id></mixed-citation></ref>
<ref id="B22"><label>22.</label><mixed-citation publication-type="other"><collab>National Center for PTSD</collab>. <comment>Life Events Checklist for DSM-5 (LEC-5) - PTSD: National Center for PTSD 2023</comment>. (<year>n.d.</year>). <comment>Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.ptsd.va.gov/professional/assessment/te-measures/life_events_checklist.asp">https://www.ptsd.va.gov/professional/assessment/te-measures/life_events_checklist.asp</ext-link> <comment>(Accessed October 20, 2024)</comment></mixed-citation></ref>
<ref id="B23"><label>23.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Perrin</surname> <given-names>S</given-names></name> <name><surname>Meiser-Stedman</surname> <given-names>R</given-names></name> <name><surname>Smith</surname> <given-names>P</given-names></name></person-group>. <article-title>The children&#x2019;s revised impact of event scale (CRIES): validity as a screening instrument for PTSD</article-title>. <source>Behav Cogn Psychother</source>. (<year>2005</year>) <volume>33</volume>:<fpage>487</fpage>&#x2013;<lpage>98</lpage>. <pub-id pub-id-type="doi">10.1017/S1352465805002419</pub-id></mixed-citation></ref>
<ref id="B24"><label>24.</label><mixed-citation publication-type="other"><comment>Children &#x0026; War Foundation. The Children&#x2019;s Impact of Event Scale-13 (CRIES -13)</comment>. (<year>n.d.</year>). <comment>Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.childrenandwar.org/measures">https://www.childrenandwar.org/measures</ext-link> <comment>(Accessed May 28, 2023)</comment></mixed-citation></ref>
<ref id="B25"><label>25.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramadan</surname> <given-names>M</given-names></name> <name><surname>Kheirallah</surname> <given-names>K</given-names></name> <name><surname>Saleh</surname> <given-names>T</given-names></name> <name><surname>Bellizzi</surname> <given-names>S</given-names></name> <name><surname>Shorman</surname> <given-names>E</given-names></name></person-group>. <article-title>The relationship between spirituality and post-traumatic stress symptoms in Syrian adolescents in Jordan</article-title>. <source>J Child Adolesc Trauma</source>. (<year>2021</year>) <volume>15</volume>:<fpage>585</fpage>&#x2013;<lpage>93</lpage>. <pub-id pub-id-type="doi">10.1007/s40653-021-00401-w</pub-id><pub-id pub-id-type="pmid">35958726</pub-id></mixed-citation></ref>
<ref id="B26"><label>26.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yonis</surname> <given-names>OB</given-names></name> <name><surname>Khader</surname> <given-names>Y</given-names></name> <name><surname>Jarboua</surname> <given-names>A</given-names></name> <name><surname>Al-Bsoul</surname> <given-names>MM</given-names></name> <name><surname>Al-Akour</surname> <given-names>N</given-names></name> <name><surname>Alfaqih</surname> <given-names>MA</given-names></name><etal/></person-group> <article-title>Post-traumatic stress disorder among Syrian adolescent refugees in Jordan</article-title>. <source>J Public Health (Oxf)</source>. (<year>2020</year>) <volume>42</volume>:<fpage>319</fpage>&#x2013;<lpage>24</lpage>. <pub-id pub-id-type="doi">10.1093/PUBMED/FDZ026</pub-id><pub-id pub-id-type="pmid">30927431</pub-id></mixed-citation></ref>
<ref id="B27"><label>27.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname> <given-names>A</given-names></name> <name><surname>Panter-Brick</surname> <given-names>C</given-names></name> <name><surname>Hadfield</surname> <given-names>K</given-names></name> <name><surname>Dajani</surname> <given-names>R</given-names></name> <name><surname>Hamoudi</surname> <given-names>A</given-names></name> <name><surname>Sheridan</surname> <given-names>M</given-names></name></person-group>. <article-title>Minds under siege: cognitive signatures of poverty and trauma in refugee and non-refugee adolescents</article-title>. <source>Child Dev</source>. (<year>2019</year>) <volume>90</volume>:<fpage>1856</fpage>&#x2013;<lpage>65</lpage>. <pub-id pub-id-type="doi">10.1111/cdev.13320</pub-id><pub-id pub-id-type="pmid">31646618</pub-id></mixed-citation></ref>
<ref id="B28"><label>28.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cisler</surname> <given-names>JM</given-names></name> <name><surname>Herringa</surname> <given-names>RJ</given-names></name></person-group>. <article-title>Posttraumatic stress disorder and the developing adolescent brain</article-title>. <source>Biol Psychiatry</source>. (<year>2021</year>) <volume>89</volume>:<fpage>144</fpage>&#x2013;<lpage>51</lpage>. <pub-id pub-id-type="doi">10.1016/j.biopsych.2020.06.001</pub-id><pub-id pub-id-type="pmid">32709416</pub-id></mixed-citation></ref>
<ref id="B29"><label>29.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nooner</surname> <given-names>KB</given-names></name> <name><surname>Linares</surname> <given-names>LO</given-names></name> <name><surname>Batinjane</surname> <given-names>J</given-names></name> <name><surname>Kramer</surname> <given-names>RA</given-names></name> <name><surname>Silva</surname> <given-names>R</given-names></name> <name><surname>Cloitre</surname> <given-names>M</given-names></name></person-group>. <article-title>Factors related to posttraumatic stress disorder in adolescence</article-title>. <source>Trauma Violence Abuse</source>. (<year>2012</year>) <volume>13</volume>:<fpage>153</fpage>&#x2013;<lpage>66</lpage>. <pub-id pub-id-type="doi">10.1177/1524838012447698</pub-id><pub-id pub-id-type="pmid">22665437</pub-id></mixed-citation></ref>
<ref id="B30"><label>30.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moretti</surname> <given-names>MM</given-names></name> <name><surname>Peled</surname> <given-names>M</given-names></name></person-group>. <article-title>Adolescent-parent attachment: bonds that support healthy development</article-title>. <source>Paediatr Child Health</source>. (<year>2004</year>) <volume>9</volume>:<fpage>551</fpage>&#x2013;<lpage>5</lpage>. <pub-id pub-id-type="doi">10.1093/pch/9.8.551</pub-id><pub-id pub-id-type="pmid">19680483</pub-id></mixed-citation></ref>
<ref id="B31"><label>31.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Garza</surname> <given-names>K</given-names></name> <name><surname>Jovanovic</surname> <given-names>T</given-names></name></person-group>. <article-title>Impact of gender on child and adolescent PTSD</article-title>. <source>Curr Psychiatry Rep</source>. (<year>2017</year>) <volume>19</volume>:<fpage>1</fpage>&#x2013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1007/S11920-017-0830-6/METRICS</pub-id><pub-id pub-id-type="pmid">28091799</pub-id></mixed-citation></ref>
<ref id="B32"><label>32.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hiscox</surname> <given-names>VL</given-names></name> <name><surname>Hiller</surname> <given-names>R</given-names></name> <name><surname>Fraser</surname> <given-names>A</given-names></name> <name><surname>Rabie</surname> <given-names>S</given-names></name> <name><surname>Stewart</surname> <given-names>J</given-names></name> <name><surname>Seedat</surname> <given-names>S</given-names></name><etal/></person-group> <article-title>Sex differences in post-traumatic stress disorder in a high adversity cohort of South African adolescents: an examination of depressive symptoms, age, and trauma type as explanatory factors</article-title>. <source>Eur J Psychotraumatol</source>. (<year>2021</year>) <volume>12</volume>. <pub-id pub-id-type="doi">10.1080/20008198.2021.1978669</pub-id><pub-id pub-id-type="pmid">34691370</pub-id></mixed-citation></ref>
<ref id="B33"><label>33.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dworkin</surname> <given-names>ER</given-names></name> <name><surname>Menon</surname> <given-names>SV</given-names></name> <name><surname>Bystrynski</surname> <given-names>J</given-names></name> <name><surname>Allen</surname> <given-names>NE</given-names></name></person-group>. <article-title>Sexual assault victimization and psychopathology: a review and meta-analysis</article-title>. <source>Clin Psychol Rev</source>. (<year>2017</year>) <volume>56</volume>:<fpage>65</fpage>&#x2013;<lpage>81</lpage>. <pub-id pub-id-type="doi">10.1016/j.cpr.2017.06.002</pub-id><pub-id pub-id-type="pmid">28689071</pub-id></mixed-citation></ref>
<ref id="B34"><label>34.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haering</surname> <given-names>S</given-names></name> <name><surname>Meyer</surname> <given-names>C</given-names></name> <name><surname>Schulze</surname> <given-names>L</given-names></name> <name><surname>Conrad</surname> <given-names>E</given-names></name> <name><surname>Blecker</surname> <given-names>MK</given-names></name> <name><surname>El-Haj-Mohamad</surname> <given-names>R</given-names></name><etal/></person-group> <article-title>Sex and gender differences in risk factors for posttraumatic stress disorder: a systematic review and meta-analysis of prospective studies</article-title>. <source>J Psychopathol Clin Sci</source>. (<year>2024</year>) <volume>133</volume>:<fpage>429</fpage>&#x2013;<lpage>44</lpage>. <pub-id pub-id-type="doi">10.1037/abn0000918</pub-id><pub-id pub-id-type="pmid">38815081</pub-id></mixed-citation></ref>
<ref id="B35"><label>35.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Miranda-Mendizabal</surname> <given-names>A</given-names></name> <name><surname>Castellv&#x00ED;</surname> <given-names>P</given-names></name> <name><surname>Par&#x00E9;s-Badell</surname> <given-names>O</given-names></name> <name><surname>Alayo</surname> <given-names>I</given-names></name> <name><surname>Almenara</surname> <given-names>J</given-names></name> <name><surname>Alonso</surname> <given-names>I</given-names></name><etal/></person-group> <article-title>Gender differences in suicidal behavior in adolescents and young adults: systematic review and meta-analysis of longitudinal studies</article-title>. <source>Int J Public Health</source>. (<year>2019</year>) <volume>64</volume>:<fpage>265</fpage>&#x2013;<lpage>83</lpage>. <pub-id pub-id-type="doi">10.1007/s00038-018-1196-1</pub-id><pub-id pub-id-type="pmid">30635683</pub-id></mixed-citation></ref>
<ref id="B36"><label>36.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Olff</surname> <given-names>M</given-names></name></person-group>. <article-title>Sex and gender differences in post-traumatic stress disorder: an update</article-title>. <source>Eur J Psychotraumatol</source>. (<year>2017</year>) <volume>8</volume>(<issue>sup4</issue>):<fpage>1351204</fpage>. <pub-id pub-id-type="doi">10.1080/20008198.2017.1351204</pub-id></mixed-citation></ref>
<ref id="B37"><label>37.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Finkelhor</surname> <given-names>D</given-names></name> <name><surname>Turner</surname> <given-names>HA</given-names></name> <name><surname>Shattuck</surname> <given-names>A</given-names></name> <name><surname>Hamby</surname> <given-names>SL</given-names></name></person-group>. <article-title>Prevalence of childhood exposure to violence, crime, and abuse: results from the national survey of children&#x2019;s exposure to violence</article-title>. <source>JAMA Pediatr</source>. (<year>2015</year>) <volume>169</volume>:<fpage>746</fpage>&#x2013;<lpage>54</lpage>. <pub-id pub-id-type="doi">10.1001/JAMAPEDIATRICS.2015.0676</pub-id><pub-id pub-id-type="pmid">26121291</pub-id></mixed-citation></ref>
<ref id="B38"><label>38.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Flannery</surname> <given-names>DJ</given-names></name> <name><surname>Wester</surname> <given-names>KL</given-names></name> <name><surname>Singer</surname> <given-names>MI</given-names></name></person-group>. <article-title>Impact of exposure to violence in school on child and adolescent mental health and behavior</article-title>. <source>J Community Psychol</source>. (<year>2004</year>) <volume>32</volume>:<fpage>559</fpage>&#x2013;<lpage>73</lpage>. <pub-id pub-id-type="doi">10.1002/JCOP.20019;REQUESTEDJOURNAL:JOURNAL:15206629;WGROUP:STRING:PUBLICATION</pub-id></mixed-citation></ref>
<ref id="B39"><label>39.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lahousen</surname> <given-names>T</given-names></name> <name><surname>Unterrainer</surname> <given-names>HF</given-names></name> <name><surname>Kapfhammer</surname> <given-names>H-P</given-names></name></person-group>. <article-title>Psychobiology of attachment and trauma&#x2014;some general remarks from a clinical perspective</article-title>. <source>Front Psychiatry</source>. (<year>2019</year>) <volume>10</volume>:<fpage>914</fpage>. <pub-id pub-id-type="doi">10.3389/fpsyt.2019.00914</pub-id><pub-id pub-id-type="pmid">31920761</pub-id></mixed-citation></ref>
<ref id="B40"><label>40.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kganyago Mphaphuli</surname> <given-names>L</given-names></name></person-group>. <article-title>The impact of dysfunctional families on the mental health of children</article-title>. In: <person-group person-group-type="editor"><name><surname>Silva</surname><given-names>T</given-names></name></person-group>, editor. <source>Parenting in Modern Societies</source>. <publisher-loc>London</publisher-loc>: <publisher-name>IntechOpen</publisher-name> (<year>2023</year>). p. <fpage>10</fpage>&#x2013;<lpage>35</lpage>. <pub-id pub-id-type="doi">10.5772/intechopen.110565</pub-id></mixed-citation></ref>
<ref id="B41"><label>41.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ogle</surname> <given-names>CM</given-names></name> <name><surname>Rubin</surname> <given-names>DC</given-names></name> <name><surname>Siegler</surname> <given-names>IC</given-names></name></person-group>. <article-title>The relation between insecure attachment and posttraumatic stress: early life versus adulthood traumas</article-title>. <source>Psychol Trauma</source>. (<year>2015</year>) <volume>7</volume>:<fpage>324</fpage>&#x2013;<lpage>32</lpage>. <pub-id pub-id-type="doi">10.1037/tra0000015</pub-id><pub-id pub-id-type="pmid">26147517</pub-id></mixed-citation></ref>
<ref id="B42"><label>42.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Toth</surname> <given-names>SL</given-names></name> <name><surname>Cicchetti</surname> <given-names>D</given-names></name></person-group>. <article-title>A developmental psychopathology perspective on child maltreatment</article-title>. <source>Child Maltreat</source>. (<year>2013</year>) <volume>18</volume>:<fpage>135</fpage>&#x2013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1177/1077559513500380</pub-id><pub-id pub-id-type="pmid">23886641</pub-id></mixed-citation></ref>
<ref id="B43"><label>43.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sippel</surname> <given-names>LM</given-names></name> <name><surname>Liebman</surname> <given-names>RE</given-names></name> <name><surname>Sch&#x00E4;fer</surname> <given-names>SK</given-names></name> <name><surname>Ennis</surname> <given-names>N</given-names></name> <name><surname>Mattern</surname> <given-names>AC</given-names></name> <name><surname>Rozek</surname> <given-names>DC</given-names></name><etal/></person-group> <article-title>Sources of social support and trauma recovery: evidence for bidirectional associations from a recently trauma-exposed community sample</article-title>. <source>Behav Sci</source>. (<year>2024</year>) <volume>14</volume>:<fpage>284</fpage>. <pub-id pub-id-type="doi">10.3390/bs14040284</pub-id><pub-id pub-id-type="pmid">38667080</pub-id></mixed-citation></ref>
<ref id="B44"><label>44.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stanley</surname> <given-names>IH</given-names></name> <name><surname>Hom</surname> <given-names>MA</given-names></name> <name><surname>Chu</surname> <given-names>C</given-names></name> <name><surname>Dougherty</surname> <given-names>SP</given-names></name> <name><surname>Gallyer</surname> <given-names>AJ</given-names></name> <name><surname>Spencer-Thomas</surname> <given-names>S</given-names></name><etal/></person-group> <article-title>Perceptions of belongingness and social support attenuate PTSD symptom severity among firefighters: a multistudy investigation</article-title>. <source>Psychol Serv</source>. (<year>2019</year>) <volume>16</volume>:<fpage>543</fpage>&#x2013;<lpage>55</lpage>. <pub-id pub-id-type="doi">10.1037/ser0000240</pub-id><pub-id pub-id-type="pmid">29595287</pub-id></mixed-citation></ref>
<ref id="B45"><label>45.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alvis</surname> <given-names>L</given-names></name> <name><surname>Zhang</surname> <given-names>N</given-names></name> <name><surname>Sandler</surname> <given-names>IN</given-names></name> <name><surname>Kaplow</surname> <given-names>JB</given-names></name></person-group>. <article-title>Developmental manifestations of grief in children and adolescents: caregivers as key grief facilitators</article-title>. <source>J Child Adolesc Trauma</source>. (<year>2023</year>) <volume>16</volume>:<fpage>447</fpage>&#x2013;<lpage>57</lpage>. <pub-id pub-id-type="doi">10.1007/s40653-021-00435-0</pub-id><pub-id pub-id-type="pmid">35106114</pub-id></mixed-citation></ref>
<ref id="B46"><label>46.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kaplow</surname> <given-names>JB</given-names></name> <name><surname>Saunders</surname> <given-names>J</given-names></name> <name><surname>Angold</surname> <given-names>A</given-names></name> <name><surname>Costello</surname> <given-names>EJ</given-names></name></person-group>. <article-title>Psychiatric symptoms in bereaved versus nonbereaved youth and young adults: a longitudinal epidemiological study</article-title>. <source>J Am Acad Child Adolesc Psychiatry</source>. (<year>2010</year>) <volume>49</volume>:<fpage>1145</fpage>&#x2013;<lpage>54</lpage>. <pub-id pub-id-type="doi">10.1016/j.jaac.2010.08.004</pub-id><pub-id pub-id-type="pmid">20970702</pub-id></mixed-citation></ref>
<ref id="B47"><label>47.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Keyes</surname> <given-names>KM</given-names></name> <name><surname>Pratt</surname> <given-names>C</given-names></name> <name><surname>Galea</surname> <given-names>S</given-names></name> <name><surname>McLaughlin</surname> <given-names>KA</given-names></name> <name><surname>Koenen</surname> <given-names>KC</given-names></name> <name><surname>Shear</surname> <given-names>MK</given-names></name></person-group>. <article-title>The burden of loss: unexpected death of a loved one and psychiatric disorders across the life course in a national study</article-title>. <source>Am J Psychiatry</source>. (<year>2014</year>) <volume>171</volume>:<fpage>864</fpage>&#x2013;<lpage>71</lpage>. <pub-id pub-id-type="doi">10.1176/appi.ajp.2014.13081132</pub-id><pub-id pub-id-type="pmid">24832609</pub-id></mixed-citation></ref>
<ref id="B48"><label>48.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname> <given-names>KM</given-names></name> <name><surname>Kim</surname> <given-names>D</given-names></name> <name><surname>Chung</surname> <given-names>US</given-names></name></person-group>. <article-title>Investigation of the trend in adolescent mental health and its related social factors: a multi-year cross-sectional study for 13 years</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2020</year>) <volume>17</volume>:<fpage>5405</fpage>. <pub-id pub-id-type="doi">10.3390/ijerph17155405</pub-id><pub-id pub-id-type="pmid">32727147</pub-id></mixed-citation></ref>
<ref id="B49"><label>49.</label><mixed-citation publication-type="other"><collab>CDC</collab>. <comment>Post-traumatic Stress Disorder in Children 2024. Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/children-mental-health/about/post-traumatic-stress-disorder-in-children.html?CDC_AAref_Val=https://www.cdc.gov/childrensmentalhealth/ptsd.html">https://www.cdc.gov/children-mental-health/about/post-traumatic-stress-disorder-in-children.html?CDC_AAref_Val&#x003D;https://www.cdc.gov/childrensmentalhealth/ptsd.html</ext-link> <comment>(Accessed October 20, 2024)</comment></mixed-citation></ref>
<ref id="B50"><label>50.</label><mixed-citation publication-type="other"><collab>National Center for PTSD</collab>. <comment>PTSD in Children and Teens 2024. Available online at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.ptsd.va.gov/understand/what/ptsd_basics.asp">https://www.ptsd.va.gov/understand/what/ptsd_basics.asp</ext-link> <comment>(Accessed November 29, 2025).</comment></mixed-citation></ref>
<ref id="B51"><label>51.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sprang</surname> <given-names>G</given-names></name> <name><surname>Eslinger</surname> <given-names>J</given-names></name> <name><surname>Whitt-Woosley</surname> <given-names>A</given-names></name> <name><surname>Gusler</surname> <given-names>S</given-names></name> <name><surname>Clemans</surname> <given-names>T</given-names></name></person-group>. <article-title>Child traumatic stress and COVID-19: the impact of the pandemic on a clinical sample of children in trauma treatment</article-title>. <source>J Child Adolesc Trauma</source>. (<year>2023</year>) <volume>16</volume>:<fpage>659</fpage>&#x2013;<lpage>70</lpage>. <pub-id pub-id-type="doi">10.1007/s40653-023-00531-3</pub-id></mixed-citation></ref>
<ref id="B52"><label>52.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scott</surname> <given-names>SR</given-names></name> <name><surname>Rivera</surname> <given-names>KM</given-names></name> <name><surname>Rushing</surname> <given-names>E</given-names></name> <name><surname>Manczak</surname> <given-names>EM</given-names></name> <name><surname>Rozek</surname> <given-names>CS</given-names></name> <name><surname>Doom</surname> <given-names>JR</given-names></name></person-group>. <article-title>&#x0022;I hate this&#x0022;: a qualitative analysis of Adolescents&#x2019; self-reported challenges during the COVID-19 pandemic</article-title>. <source>J Adolesc Health</source>. (<year>2021</year>) <volume>68</volume>:<fpage>262</fpage>&#x2013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1016/j.jadohealth.2020.11.010</pub-id><pub-id pub-id-type="pmid">33288454</pub-id></mixed-citation></ref>
<ref id="B53"><label>53.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shah</surname> <given-names>S</given-names></name> <name><surname>Kaul</surname> <given-names>A</given-names></name> <name><surname>Shah</surname> <given-names>R</given-names></name> <name><surname>Maddipoti</surname> <given-names>S</given-names></name></person-group>. <article-title>Impact of coronavirus disease 2019 pandemic and lockdown on mental health symptoms in children</article-title>. <source>Indian Pediatr</source>. (<year>2020</year>) <volume>58</volume>:<fpage>75</fpage>&#x2013;<lpage>6</lpage>. <comment>Available online at: <ext-link ext-link-type="uri" xlink:href="https://pubmed.ncbi.nlm.nih.gov/33257601/">https://pubmed.ncbi.nlm.nih.gov/33257601/</ext-link> (Accessed December 21, 2025).</comment><pub-id pub-id-type="pmid">33257601</pub-id></mixed-citation></ref>
<ref id="B54"><label>54.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rizvi</surname> <given-names>SFI</given-names></name> <name><surname>Najam</surname> <given-names>N</given-names></name></person-group>. <article-title>Parental psychological abuse toward children and mental health problems in adolescence</article-title>. <source>Pak J Med Sci</source>. (<year>2014</year>) <volume>30</volume>:<fpage>256</fpage>.<pub-id pub-id-type="pmid">24772122</pub-id></mixed-citation></ref>
<ref id="B55"><label>55.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Watts</surname> <given-names>J</given-names></name> <name><surname>Leeman</surname> <given-names>M</given-names></name> <name><surname>O&#x2019;Sullivan</surname> <given-names>D</given-names></name> <name><surname>Castleberry</surname> <given-names>J</given-names></name> <name><surname>Baniya</surname> <given-names>G</given-names></name></person-group>. <article-title>Childhood emotional maltreatment and post-traumatic stress disorder in the context of centrality of the event and intrusive rumination</article-title>. <source>Rehabil Couns Bull</source>. (<year>2021</year>) <volume>64</volume>:<fpage>108</fpage>&#x2013;<lpage>17</lpage>. <pub-id pub-id-type="doi">10.1177/0034355220925889</pub-id></mixed-citation></ref>
<ref id="B56"><label>56.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Slade</surname> <given-names>EP</given-names></name> <name><surname>Wissow</surname> <given-names>LS</given-names></name></person-group>. <article-title>The influence of childhood maltreatment on adolescents&#x2019; academic performance</article-title>. <source>Econ Educ Rev</source>. (<year>2007</year>) <volume>26</volume>:<fpage>604</fpage>. <pub-id pub-id-type="doi">10.1016/J.ECONEDUREV.2006.10.003</pub-id><pub-id pub-id-type="pmid">18037979</pub-id></mixed-citation></ref>
<ref id="B57"><label>57.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Famularo</surname> <given-names>R</given-names></name> <name><surname>Fenton</surname> <given-names>T</given-names></name> <name><surname>Augustyn</surname> <given-names>M</given-names></name> <name><surname>Zuckerman</surname> <given-names>B</given-names></name></person-group>. <article-title>Persistence of pediatric post traumatic stress disorder after 2 years</article-title>. <source>Child Abuse Negl</source>. (<year>1996</year>) <volume>20</volume>:<fpage>1245</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1016/S0145-2134(96)00119-6</pub-id><pub-id pub-id-type="pmid">8985614</pub-id></mixed-citation></ref>
<ref id="B58"><label>58.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Anastas</surname> <given-names>JW</given-names></name> <name><surname>Payne</surname> <given-names>NA</given-names></name> <name><surname>Ghuman</surname> <given-names>SA</given-names></name></person-group>. <article-title>Adverse childhood experiences and complex post-traumatic stress in pregnant teens: a pilot study</article-title>. <source>Matern Child Health J</source>. (<year>2021</year>) <volume>25</volume>:<fpage>741</fpage>&#x2013;<lpage>50</lpage>. <pub-id pub-id-type="doi">10.1007/s10995-020-03041-y</pub-id><pub-id pub-id-type="pmid">33389455</pub-id></mixed-citation></ref>
<ref id="B59"><label>59.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Briere</surname> <given-names>J</given-names></name> <name><surname>Agee</surname> <given-names>E</given-names></name> <name><surname>Dietrich</surname> <given-names>A</given-names></name></person-group>. <article-title>Cumulative trauma and current posttraumatic stress disorder status in general population and inmate samples</article-title>. <source>Psychol Trauma</source>. (<year>2016</year>) <volume>8</volume>:<fpage>439</fpage>&#x2013;<lpage>46</lpage>. <pub-id pub-id-type="doi">10.1037/tra0000107</pub-id><pub-id pub-id-type="pmid">26752099</pub-id></mixed-citation></ref>
<ref id="B60"><label>60.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ferraj&#x00E3;o</surname> <given-names>P</given-names></name> <name><surname>Frias</surname> <given-names>F</given-names></name> <name><surname>Elklit</surname> <given-names>A</given-names></name></person-group>. <article-title>Exploring independent and cumulative effects of adverse childhood experiences on PTSD and CPTSD a study in Ugandan adolescents</article-title>. <source>Children</source>. (<year>2024</year>) <volume>11</volume>:<fpage>517</fpage>. <pub-id pub-id-type="doi">10.3390/children11050517</pub-id></mixed-citation></ref>
<ref id="B61"><label>61.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhu</surname> <given-names>Y</given-names></name> <name><surname>Zhang</surname> <given-names>G</given-names></name> <name><surname>Anme</surname> <given-names>T</given-names></name></person-group>. <article-title>Adverse childhood experiences, resilience, and emotional problems in young Chinese children</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2023</year>) <volume>20</volume>:<fpage>3028</fpage>. <pub-id pub-id-type="doi">10.3390/ijerph20043028</pub-id><pub-id pub-id-type="pmid">36833720</pub-id></mixed-citation></ref>
<ref id="B62"><label>62.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kalmakis</surname> <given-names>KA</given-names></name> <name><surname>Chandler</surname> <given-names>GE</given-names></name></person-group>. <article-title>Health consequences of adverse childhood experiences: a systematic review</article-title>. <source>J Am Assoc Nurse Pract</source>. (<year>2015</year>) <volume>27</volume>:<fpage>457</fpage>&#x2013;<lpage>65</lpage>. <pub-id pub-id-type="doi">10.1002/2327-6924.12215</pub-id><pub-id pub-id-type="pmid">25755161</pub-id></mixed-citation></ref>
<ref id="B63"><label>63.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Greeson</surname> <given-names>JK</given-names></name> <name><surname>Briggs</surname> <given-names>EC</given-names></name> <name><surname>Kisiel</surname> <given-names>CL</given-names></name> <name><surname>Layne</surname> <given-names>CM</given-names></name> <name><surname>Ake</surname> <given-names>GS</given-names></name> <name><surname>Ko</surname> <given-names>SJ</given-names></name><etal/></person-group> <article-title>Complex trauma and mental health in children and adolescents placed in foster care</article-title>. <source>Child Welfare</source>. (<year>2011</year>) <volume>90</volume>:<fpage>91</fpage>&#x2013;<lpage>108</lpage>.<pub-id pub-id-type="pmid">22533044</pub-id></mixed-citation></ref>
<ref id="B64"><label>64.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Sahle</surname> <given-names>B</given-names></name> <name><surname>Reavley</surname> <given-names>N</given-names></name> <name><surname>Morgan</surname> <given-names>A</given-names></name> <name><surname>Hui Yap</surname> <given-names>MB</given-names></name> <name><surname>Reupert</surname> <given-names>A</given-names></name> <name><surname>Loftus</surname> <given-names>H</given-names></name><etal/></person-group> <article-title>Communication Brief: Summary of interventions to prevent adverse childhood experiences and reduce their negative impact on children&#x0027;s mental health: an evidence based review</article-title>. <publisher-name>Centre of Research Excellence in Childhood Adversity and Mental Health</publisher-name>. (<year>2020</year>). <comment>Available online at: <ext-link ext-link-type="uri" xlink:href="https://www.childhoodadversity.org.au/media/olcjn2nw/summary_evidence_interventions_report_final_aug20.pdf">https://www.childhoodadversity.org.au/media/olcjn2nw/summary_evidence_interventions_report_final_aug20.pdf</ext-link> (Accessed November 29, 2025).</comment></mixed-citation></ref>
<ref id="B65"><label>65.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname> <given-names>G</given-names></name> <name><surname>Werner</surname> <given-names>K</given-names></name> <name><surname>Alqunaiebet</surname> <given-names>A</given-names></name> <name><surname>Hamza</surname> <given-names>MM</given-names></name> <name><surname>Alkanhal</surname> <given-names>N</given-names></name> <name><surname>Alsukait</surname> <given-names>RF</given-names></name><etal/></person-group> <article-title>The cost-effectiveness of school-based interventions for chronic diseases: a systematic review</article-title>. <source>Cost Eff Resour Alloc</source>. (<year>2024</year>) <volume>22</volume>:<fpage>1</fpage>&#x2013;<lpage>12</lpage>. <pub-id pub-id-type="doi">10.1186/S12962-024-00511-W/FIGURES/1</pub-id><pub-id pub-id-type="pmid">38178078</pub-id></mixed-citation></ref>
<ref id="B66"><label>66.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lorenc</surname> <given-names>T</given-names></name> <name><surname>Lester</surname> <given-names>S</given-names></name> <name><surname>Sutcliffe</surname> <given-names>K</given-names></name> <name><surname>Stansfield</surname> <given-names>C</given-names></name> <name><surname>Thomas</surname> <given-names>J</given-names></name></person-group>. <article-title>Interventions to support people exposed to adverse childhood experiences: systematic review of systematic reviews</article-title>. <source>BMC Public Health</source>. (<year>2020</year>) <volume>20</volume>:<fpage>1</fpage>&#x2013;<lpage>10</lpage>. <pub-id pub-id-type="doi">10.1186/S12889-020-08789-0/TABLES/1</pub-id><pub-id pub-id-type="pmid">31898494</pub-id></mixed-citation></ref>
<ref id="B67"><label>67.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mohammadi</surname> <given-names>AQ</given-names></name> <name><surname>Neyazi</surname> <given-names>A</given-names></name> <name><surname>Habibi</surname> <given-names>D</given-names></name> <name><surname>Mehmood</surname> <given-names>Q</given-names></name> <name><surname>Neyazi</surname> <given-names>M</given-names></name> <name><surname>Griffiths</surname> <given-names>MD</given-names></name></person-group>. <article-title>Female education ban by the Taliban: a descriptive survey study on suicidal ideation, mental health, and health-related quality of life among girls in Afghanistan</article-title>. <source>J Public Health (Bangkok)</source>. (<year>2024</year>) <volume>46</volume>:<fpage>e439</fpage>&#x2013;<lpage>47</lpage>. <pub-id pub-id-type="doi">10.1093/pubmed/fdae111</pub-id></mixed-citation></ref></ref-list>
<fn-group>
<fn id="n1" fn-type="custom" custom-type="edited-by"><p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/927774/overview">Eva M&#x00F6;hler</ext-link>, Saarland University Hospital, Germany</p></fn>
<fn id="n2" fn-type="custom" custom-type="reviewed-by"><p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3170354/overview">Solomon Danga</ext-link>, University of the Western Cape, South Africa</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3241957/overview">Ivette Noriega</ext-link>, Begun Center for Violence Prevention Research and Education, Cleveland, United States</p></fn>
</fn-group>
</back>
</article>