Front. Chem. Frontiers in Chemistry Front. Chem. 2296-2646 Frontiers Media S.A. 1205654 10.3389/fchem.2023.1205654 Chemistry Correction Corrigendum: Chiral water-soluble molecular capsules with amphiphilic interiors Sakowicz and Szumna 10.3389/fchem.2023.1205654 Sakowicz Arkadiusz Marek Szumna Agnieszka * Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland

Edited and reviewed by: Alessandro Scarso, Ca’ Foscari University of Venice, Italy

 *Correspondence: Agnieszka Szumna, aszumna@icho.edu.pl 03 05 2023 2023 11 1205654 14 04 2023 18 04 2023 Copyright © 2023 Sakowicz and Szumna. 2023 Sakowicz and Szumna

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

 A Corrigendum on Chiral water-soluble molecular capsules with amphiphilic interiors by Sakowicz AM and Szumna A (2022). Front. Chem. 10:883093. doi: 10.3389/fchem.2022.883093 host–guest system salt bridge self-assembly supramolecular chemistry water chemistry section-at-acceptance Supramolecular Chemistry

In the original article, there was an error in Figure 1 as published. Based on the re-analysis of published data and additional experiments, the authors claim that the molecular structure of L-GluR is cyclic. The corrected Figure 1 and its caption appear below.

Structures of the compounds used in this study along with notation of the NMR signals: (A,B) hydrophobic capsule (L-PheR)2 and its binding motif (ref. Kuberski and Szumna, 2009); (C) synthesis of water-soluble cavitands; (D) structure of reference cavitand PhR (ref. Setner and Szumna, 2019); and (E) guest molecules.

In the original article, there were errors in the Supplementary Figures S2, S4, S68, and S69. The errors come from erroneous assignment of 13C NMR carbonyl signals (k,h) in the spectrum at pH 11 and in the cyclic structure of L-GluR. The correct figures can be viewed in the updated original article.

Continuing our studies on amphiphilic molecular capsules using dipeptides as components, we have found that dipeptides containing glutamic acid are prone to intramolecular cyclization. Therefore, we re-analyzed the published analytical data for (L-GluR)2 and have found similar spectral features indicating that intramolecular cyclization might have taken place for (L-GluR)2. Specifically, the ESI MS spectrum of L-GluR shows the signal of (M-4H2O-H)− (Supplementary Figure S66). After re-interpretation of the HMBC spectrum and the re-assignment of carbonyl signals (h, k), we found an additional low-intensity correlation between Hg and Ck. The ESI MS spectrum alone is not an unambiguous proof, because water loss in the gas phase is often observed for amino acid derivatives possessing carboxylic side chains, especially for large molecules that require high ionization energy in the electrospray technique (like here). However, together with the HMBC correlation and new data for dipeptides, it strongly suggest that L-GluR underwent intramolecular cyclization. Therefore, the reason for this correction is that the molecular structure of L-GluR is most likely cyclic. As claimed in the paper, formation of dimeric structures is still supported by DOSY, ECD and complexation studies for L-GluR. However, the mode of dimerization for L-GluR is most likely different than for (L-ArgR)2. We suggest that the formation of (L-GluR)2 proceeds through hydrophobic clustering. All experimental data (spectra, binding studies and calculations) in the paper are correct. The interpretation of data for (L-ArgR)2 also remains correct, without reservations. It is still claimed that both compounds form dimeric capsules, and are effective in encapsulation of guest molecules and the calculated values of Kass are correct within an experimental error. Therefore, despite different structure of (L-GluR)2, all conclusions remain valid.

The following corrections have been made accordingly:

In Introduction, second paragraph, page 2, it was previously stated: “We demonstrate that electrostatic interactions between the backbones of amino acids are effective in inducing their self-assembly in water, and this mode leaves side chains available for additional interactions.”

The corrected sentence appears below:

“We demonstrate that electrostatic and hydrophobic interactions are effective in inducing their self-assembly in water.”

In section 3 Original Research, “3.1 Results and Discussion”, “3.1.1 Design and Synthesis”, second paragraph, page 3, it was previously stated: “Among the amino acids tested (Glu, Asp, Arg, and His), only glutamic acid and arginine gave the target cavitands (L-GluR, D-GluR, and L-ArgR).”

The corrected section appears below:

“Among the amino acids tested (Glu, Asp, Arg, and His), only glutamic acid and arginine gave the cavitands (L-GluR, D-GluR, and L-ArgR). Nevertheless, the ESI MS spectrum of L-GluR shows the signal of (M-4H2O – H]− (Supplementary Figure S66), and in the HMBC spectrum, we found an additional low-intensity correlation between Hg and Ck (Supplementary Figure S4), which suggests that L-GluR, in contrary to L-ArgR, underwent intramolecular cyclization (Figure 1C).”

In section “3.1.2 Self-Assembly of Homocapsules”, first paragraph, page 3, it was previously stated: “The cavitands L-GluR and L-ArgR are expected to self-assemble to dimeric capsules using electrostatic interactions between zwitterionic structures involving their “backbone groups” (Figure 1B).”

The corrected sentence appears below:

“The cavitands are expected to self-assemble to dimeric capsules using electrostatic interactions between zwitterionic structures involving their “backbone groups” (for L-ArgR, Figure 1B; Supplementary Figure S69) or by hydrophobic clustering (for L-GluR, Supplementary Figure S68).”

In section “3.1.2. Self-Assembly of Homocapsules”, second paragraph, page 4, it was previously stated: “This value is in reasonable agreement with the estimated r H for a dimeric (L-GluR)2 [r H (dimer) = 10.8 Å, r H (cavitand) = 9.2 Å calculated by averaging the dimensions of the model structure, Supplementary Figures S68 and S69].”

The corrected sentence appears below:

“This value is in reasonable agreement with the estimated r H for a dimeric (L-GluR)2 [r H (dimer) = 9.1 Å, r H (cavitand) = 7.2 Å calculated by averaging the dimensions of the model structure, Supplementary Figures S68 and S69].”

In section “3.1.2 Self-Assembly of Homocapsules”, paragraph 5, page 5, it was previously stated: “Quite intriguingly, L-GluR does not self-assemble in DMSO, which is a less polar solvent than water.”

The corrected sentence appears below:

“In agreement with the hydrophobic character interactions, L-GluR does not self-assemble in DMSO.”

In section “3.1.5 Screening of Encapsulation Properties”, first paragraph, page 6, it was previously stated: “Assuming that the binding motif of hydrophilic capsules is similar to that of hydrophobic (L-PheR)2, the size of the cavity can be estimated as c.a. 300 Å3, and it can be expected that the interior of the cavity has a mixed character—the “poles” are hydrophobic, while the “equator” part is polar (Kuberski and Szumna, 2009).”

The corrected sentence appears below:

“Assuming that the binding motif of hydrophilic capsules is similar to that of hydrophobic (L-PheR)2, in case of (L-ArgR)2 (Kuberski and Szumna, 2009) or based on hydrophobic clustering, in case of (L-GluR)2, the size of the cavity can be estimated as c.a. 300 Å3.”

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.