AUTHOR=Yang Guoqiang , Fan Xuehui , Mazhar Maryam , Yang Sijin , Xu Houping , Dechsupa Nathupakorn , Wang Li 

TITLE=Mesenchymal Stem Cell Application and Its Therapeutic Mechanisms in Intracerebral Hemorrhage

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2022.898497

DOI=10.3389/fncel.2022.898497

ISSN=1662-5102

ABSTRACT=Intracerebral hemorrhage (ICH) is one of the leading causes of death and long-term disability worldwide. The ICH is characterized by motor and sensory dysfunction that is usually associated with poor prognosis. However, there is no effective treatment available currently. In recent years, the neuroprotection and repairment capacity of mesenchymal stem cells (MSCs) has been widely investigated after ICH. MSCs therapy have demonstrated improved outcomes for treating ICH-induced neuronal defects. The neural network reconstruction and neurological function recovery were enhanced in rodent ICH models through the mechanisms of neurogenesis, angiogenesis, anti-inflammation, and anti-apoptosis. MSCs also exert many unique biological effects, including self-recovery by producing growth factors and cytokines, regenerative repair, immunomodulation, and neuroprotection against oxidative stress, providing a promising cellular therapeutic approach for the treatment of ICH. Taken together, our goal is to discuss the characteristics following ICH, including the mechanism and potential promising therapeutic targets of MSCs, aiming at providing new clues for future therapeutic strategies. Furthermore, some efficient strategies for the outcome improvement of MSCs transplantation were proposed.