AUTHOR=Yang Zong Chao , Han Zhang Rui , Li Xiang Yang , Duan Ya Bin 

TITLE=Antimicrobial resistance pattern due to oxygen gap at high altitudes

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1673102

DOI=10.3389/fcimb.2025.1673102

ISSN=2235-2988

ABSTRACT=Over the past 10 years, microbial resistance has seriously threatened human life and health, and the treatment of multidrug-resistant bacteria remains a challenge for clinicians, pharmacists, and infectious disease physicians. Bacterial resistance is affected by a variety of factors, such as the environment, economy, and drug abuse. This review compared the differences in bacterial resistance rates between high- and low-altitude areas and explored the relevant mechanisms of bacterial resistance in the low-oxygen environment of plateaus, providing new clinical research ideas for curbing the occurrence of bacterial resistance.