AUTHOR=Wang Lu , Dai Wen , Rao Jie , Wang Yichen , Liu Kun , Li Xing , Wang Hua , Ye Jiahuan , Fang Zhonggang , Zheng Xin 

TITLE=Rapid detection of Golgi protein 73 by MAGLUMI chemiluminescent immunoassay and the clinical value to liver fibrosis/cirrhosis patients with chronic liver disease

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1576045

DOI=10.3389/fcimb.2025.1576045

ISSN=2235-2988

ABSTRACT=ObjectiveTo investigate the diagnostic value of MAGLUMI chemiluminescent immunoassay (CLIA) for detecting Golgi protein 73 (GP73) in patients with chronic liver disease.MethodsA total of 212 patients with chronic liver disease were selected as the research subjects. METAVIR pathological staging was performed according to LSM values, and GP73 levels were detected by CLIA. Spearman analysis was used to analyze the correlation between GP73, LSM and METAVIR staging. The diagnostic efficacy of GP73 was analyzed using the ROC curve based on METAVIR staging.ResultsThe enrolled patients included 37 patients in F0/F1, 80 patients in F2, 61 patients in F3, and 34 patients in F4. There were significant differences in GP73 levels in each stage (p<0.001 for all stages). Spearman correlation analysis showed that GP73 levels were positively correlated with LSM and METAVIR stages. The AUC of GP73 in diagnosing significant liver fibrosis (F≥2), advanced liver fibrosis (F≥3), and cirrhosis (F=4) were 0.78 (95% CI: 0.72~0.84, p<0.0001), 0.83 (95% CI: 0.75~0.89, p<0.0001), 0.90 (95% CI: 0.80~0.96, p<0.0001), respectively.ConclusionGP73 detected by CLIA was positively correlated with liver fibrosis stage and LSM, and had important clinical value in diagnosis of liver fibrosis and cirrhosis in patients with chronic liver disease.