AUTHOR=Wang Yunlong , Wang Ding , Li Dongyu , Ma Yuewen 

TITLE=The role of astrocytes in ischemic stroke - mechanisms, functions and treatment

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1700564

DOI=10.3389/fcell.2025.1700564

ISSN=2296-634X

ABSTRACT=Ischemic stroke, characterized by localized cerebral hypoperfusion due to various etiologies, exhibits high global incidence and mortality rates. Astrocytes, as key structural and functional components of the neurovascular unit, play a critical role in maintaining homeostasis in the central nervous system. Following ischemic stroke, astrocytes undergo activation and adopt a distinct phenotype known as reactive astrocytes, which exert complex and dual roles in the pathological process. Upon ischemic injury, astrocyte activation often exacerbates damage and impairs functional recovery; however, it can also confer neuroprotection by shielding neurons from injury and releasing trophic factors to facilitate repair. Importantly, due to the intricate cascade of events and mechanisms involved after ischemic stroke, the precise role of astrocytes remains challenging to definitively elucidate. Nonetheless, astrocytes represent a pivotal target for therapeutic interventions in ischemic stroke. Herein, we review the activation of astrocytes following ischemic stroke, focusing on the intrinsic molecular mechanisms and functional implications of astrocyte reactivity. Additionally, we discuss the potential of combining rehabilitation technologies to enhance drug delivery and therapeutic efficacy, offering a promising strategy for the treatment of ischemic stroke.