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Orthopaedic rehabilitation and regeneration represent a transformative frontier in musculoskeletal medicine, where cutting-edge biological insights converge with advanced engineering innovations to reshape clinical development. This Research Topic compiles articles investigating the latest developments in cellular regulation, non-coding RNA biology, stem cell co-culture systems, and innovative medical technologies for orthopaedic applications. Additionally, these studies enhance the understanding of orthopaedic regeneration and provide practical strategies for clinical implementation.
(1) Non-coding RNA-mediated osteogenic regulation ( (2) 3D bioprinting and stem cell engineering ( (3) Immunomodulatory MSC therapies ( (4) Laser-engineered bioceramics (
This Research Topic underscores the necessity of hybrid solutions combining biological precision with engineered reliability, which aligns with the work of vascularized bone regeneration strategies, biofunctionalized bone grafts and additive manufacturing techniques by
WW: Validation, Conceptualization, Methodology, Investigation, Writing – review and editing, Project administration, Resources, Writing – original draft. YL: Methodology, Funding acquisition, Writing – review and editing, Software, Investigation, Writing – original draft, Resources. JL: Conceptualization, Investigation, Writing – review and editing, Methodology, Data curation. WY: Software, Data curation, Writing – review and editing, Investigation, Visualization, Validation. DZ: Conceptualization, Writing – review and editing, Project administration, Supervision, Resources, Writing – original draft, Funding acquisition.
The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by Dalian Key Medical Specialties “Peak Climbing” Program (No. 2021[243]), Youth Star of Science and Technology of Dalian (No. 2022RQ001), Liaoning Provincial Science and Technology Plan Joint Plan (No. 2024-MSLH-012).
We thank the laboratory and clinic members of Affiliated Zhongshan Hospital of Dalian University for their support.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declare that no Generative AI was used in the creation of this manuscript.
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