Front. Cell Dev. Biol. Frontiers in Cell and Developmental Biology Front. Cell Dev. Biol. 2296-634X Frontiers Media S.A. 1118466 10.3389/fcell.2022.1118466 Cell and Developmental Biology Correction Corrigendum: Electrochemically induced in vitro focal hypoxia in human neurons Wong et al. 10.3389/fcell.2022.1118466 Wong Joseph J. Y. 1 Varga Balazs V. 2 Káradóttir Ragnhildur Thóra 2 Hall Elizabeth A. H. 1 * 1 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom 2 Wellcome—MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom

Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland

 *Correspondence: Elizabeth A. H. Hall, eah16@cam.ac.uk

This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology

 05 01 2023 2022 10 1118466 07 12 2022 08 12 2022 Copyright © 2023 Wong, Varga, Káradóttir and Hall. 2023 Wong, Varga, Káradóttir and Hall

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 A Corrigendum on Electrochemically induced in vitro focal hypoxia in human neurons by Wong JJY, Varga BV, Káradóttir RT and Hall EAH (2022). Front. Cell Dev. Biol. 10:968341. doi: 10.3389/fcell.2022.968341 hypoxia electrochemistry microfluidic human cortical neural progenitor cortical neuron axon small vessel disease lacunar infarct

In the published article, there was an error in Table 2 as published. This was due to a formatting error during publication causing rows to become misplaced in the final printed copy and subscript information to be lost.

Experimental design.

Experimental design Experiment Conditions/parallel experiments Replicates
Characterisation of Pt/C Oxygen adsorption In ambient 3
Oxygen adsorption In nitrogen 3
BET In nitrogen 3
Tafel plot In nitrogen 3
Oxygen concentration change In nitrogen 3
eLOS hypoxia 6 images randomly taken with minimum 100 cells each; minimum 1,000 cells per replicate Hypoxic response Negative control 3
Hypoxic response Time conditions 3 each
Hypoxic response Positive control (DMOG 250 µM) 3
Acute hypoxia Negative control 3
Acute hypoxia Time conditions 3
Focal hypoxia Negative control 3
Focal hypoxia Position conditions 3
Focal hypoxia Positive control 3
Apoptosis study pH change Different solutions 3 each
H 2 O 2 generation Different solutions 3 each
hNPC apoptosis Negative control 3
hNPC apoptosis H2O2 concentrations 3 each
hNPC apoptosis Positive control (Staurosporine 100 nM) 3
Neuron focal hypoxia Hypoxia at microchannel device Positional conditions 3
Cortical neuron model Negative control 4
Cortical neuron model Focal hypoxia conditions 4 each
Cortical neuron model Bulk hypoxia 4

The corrected Table 2 and its caption Experimental design appear below.

In the published article, there was an error in Table 3 as published. This was due to a formatting error during publication causing rows to become misplaced in the final printed copy.

pH and H2O2 concentration under eLOS oxygen scavenging.

Scavenging conditions (n = 3) Measurand Time (mins)
0 30 180
PBKClPBKCl pH [H2O2] 7.3 ± 0.1Negative 7.3 ± 0.10.8 ± 0.3 µM 7.3 ± 0.10.8 ± 0.3 µM
PBKCl with catalasePBKCl with catalase pH [H2O2] 7.3 ± 0.1Negative 7.3 ± 0.1Negative 7.2 ± 0.1Negative
DMEM/F-12DMEM/F-12 pH [H2O2] 7.6 ± 0.1Negative 7.6 ± 0.10.8 ± 0.3 µM 7.6 ± 0.1Trace amount
DMEM/F-12 with catalaseDMEM/F-12 with catalase pH [H2O2] 7.4 ± 0.1Negative 7.4 ± 0.1Negative 7.4 ± 0.1Negative

The corrected Table 3 and its caption pH and H2O2 concentration under eLOS oxygen scavenging appear below.

Error in Table carried over to the index figure.

In the published article, there was an error in Index figure as published. This arose as a carry-over of the error in the formatting of the table that the publishers used as index figure A corrected index figure appears below corresponding to Figure 10 in the manuscript.

Focal hypoxia in a human cortical neuron microchannel model. (A) Schematic presentation of the microchannel model. Representative confocal tile image of neurons growing across the microchannels. Cyan: cell nucleus; green: axons. (B) Representative confocal image of cell nucleus (cyan) at the end chambers and axons in the central chamber after hypoxic insults. (C) Quantitative analysis of cells with chromatin condensation (n = 4).

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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