Front. Cell Dev. Biol. Frontiers in Cell and Developmental Biology Front. Cell Dev. Biol. 2296-634X Frontiers Media S.A. 10.3389/fcell.2020.00462 Cell and Developmental Biology Correction Corrigendum: Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway Li Yu 1 2 Ding Hongyan 1 Liu Leihong 1 Song Yuxiang 2 Du Xiliang 2 Feng Shibin 1 Wang Xichun 1 Li Xiaobing 2 Wang Zhe 2 Li Xinwei 2 Li Jinchun 1 Wu Jinjie 1 Liu Guowen 2 * 1College of Animal Science and Technology, Anhui Agricultural University, Hefei, China 2Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China

Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland

 *Correspondence: Guowen Liu liuguowen2008@163.com

This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology

 19 06 2020 2020 8 462 04 05 2020 18 05 2020 Copyright © 2020 Li, Ding, Liu, Song, Du, Feng, Wang, Li, Wang, Li, Li, Wu and Liu. 2020 Li, Ding, Liu, Song, Du, Feng, Wang, Li, Wang, Li, Li, Wu and Liu

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 A Corrigendum on Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway by Li, Y., Ding, H., Liu, L., Song, Y., Du, X., Feng, S., et al. (2020). Front. Cell Dev. Biol. 8:245. doi: 10.3389/fcell.2020.00245 NEFA apoptosis mitochondria-mediated ROS-JNK/ERK signaling pathway dairy cow hepatocyte

In the original article, there was a mistake in Figures 7 and 8 as published. The word “Necueus” should be changed to “Nucleus.” We have also removed the red line in Figure 8.

Effect of NEFA on the activation of p53. (A) The protein expression levels and (B) quantification of p53 in dairy cows heaptocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM). (C) The protein expression levels and (D) quantification of p53 in dairy cows heaptocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (E) The transcriptional activity of p53 in dairy cows hepatocytes treated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (F) The NEFA-induced translocation of p53 from the cytosol to the nucleus in dairy cows hepatocytes incubated without or with NEFA (2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). Hepatocytes were fixed, stained with a specific antibody against p53 (red fluorescence) and counterstained with Hoechst 33258 (blue fluorescence). All results were obtained from three independent experiments and are expressed as the mean ± SD. *p < 0.05 and **p < 0.01 vs. the control group.

NEFA induce the inhibition of Nrf2 in dairy cow hepatocytes. (A) The protein expression levels and (B) quantification of Nrf2 in dairy cows heaptocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM). (C) The protein expression levels and (D) quantification of Nrf2 in dairy cows hepatocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (E) The transcriptional activity of Nrf2 in dairy cows treated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (F) The NEFA-induced translocation of Nrf2 from the cytosol to the nucleus in dairy cows hepatocytes incubated without or with NEFA (2.4 mM) in the absence or presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). Hepatocytes were fixed, stained with a specific antibody against Nrf2 (red fluorescence) and counterstained with Hoechst 33258 (blue fluorescence). All results were obtained from three independent experiments and are expressed as the mean ± SD. *p < 0.05 and **p < 0.01 vs. the control group.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.