AUTHOR=Allaham Haytham , Bennett Samuel , Sonbol Mark , Annabathula Rahul , Barr Brian 

TITLE=Patent foramen ovale as a rare cause of sudden refractory hypoxemia: a case report

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1715242

DOI=10.3389/fcvm.2025.1715242

ISSN=2297-055X

ABSTRACT=An 80-year-old man presented with progressive dyspnea and severe hypoxemia refractory to high-flow oxygen therapy and was found to have a large persistent patent foramen ovale (PFO)-mediated right-to-left shunt (RTLS). The patient underwent successful percutaneous PFO closure via a 35 mm Amplatzer septal occluder guided by intracardiac echocardiography (ICE), resulting in complete resolution of his hypoxia within 24 h. This case report highlights the workup of systemic refractory hypoxemia, the importance of cardiac shunt physiology in considering an RTLS, and the utility of PFO closure under ICE guidance. For patients with a PFO-mediated RTLS, percutaneous closure is an effective therapeutic option.