AUTHOR=Xiao Chuan-Yong , Han Wen-Ya , Wang Han-Sheng , Qian Xin , Yuan Ling-Ling , Wang Mei-Fang , Liu Yu-Quan 

TITLE=Case Report: Coexisting cardiac cavernous hemangioma and sarcoidosis in a single lesion: a first reported case confirmed by surgical resection

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1707426

DOI=10.3389/fcvm.2025.1707426

ISSN=2297-055X

ABSTRACT=Cardiac hemangioma (CH) is a rare benign cardiac tumor whose clinical manifestations—including arrhythmias, heart failure, and pericardial effusion—vary by anatomical location. Sarcoidosis is a multisystem disorder of unknown etiology characterized by non-caseating granulomas, commonly involving the lungs, eyes, and skin, with cardiac involvement being relatively uncommon. To date, no cases of concurrent cardiac hemangioma and cardiac sarcoidosis have been reported worldwide. We herein describe a patient with established sarcoidosis who, during follow-up, exhibited progressive enlargement of a cardiac mass. Surgical resection confirmed the co-existence of cardiac hemangioma and cardiac sarcoidosis within the same anatomical region. Based on these findings, we propose a pathophysiological mechanism wherein cardiac sarcoidosis causes microvascular injury, leading to structural alterations that may promote the development of cardiac hemangioma. The following report details the diagnostic and therapeutic course of this patient.