AUTHOR=Sun Meng , Fu XiaoHong , Gao Jia , Guo Min , Yin Wenjie , Wang Rui 

TITLE=Pulsed field ablation for atrial fibrillation: clinical applications and research advances

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1679578

DOI=10.3389/fcvm.2025.1679578

ISSN=2297-055X

ABSTRACT=Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with increased risks of stroke, heart failure, and mortality. With the advancement of catheter ablation technology, pulsed field ablation (PFA), a novel nonthermal ablation modality, has garnered growing attention due to its myocardial selectivity and favorable safety profile. This review systematically summarizes the biophysical principles, clinical advantages, catheter systems, special population applications, limitations, and future directions of PFA based on the latest evidence.