AUTHOR=Wu Jinqiao , Chen Min , Peng Ze , Sun Yao , Jin Juan 

TITLE=Mechanism and research progress of MAPK signaling pathway in myocardial fibrosis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1667568

DOI=10.3389/fcvm.2025.1667568

ISSN=2297-055X

ABSTRACT=Myocardial fibrosis (MF) is a hallmark pathological outcome of many cardiovascular diseases and a key component of cardiac remodeling. The p38 MAPK, JNK, and ERK signaling pathways are central to this process. This review summarizes the roles and interactions of these factors in MF and identifies relevant drug and non-pharmacological therapies targeting these pathways.