AUTHOR=Luo Ting , Yi Dong , Qiu Lingzhi , Yang Zhengle , Xu Xiaodie , Song Dan , Hua Zhengdong , Chen Xufa , Wang Bingyin , Yan Hua 

TITLE=Hybrid coronary revascularization vs. PCI in high-risk multivessel coronary artery disease: a two-center, two-year utcome comparison

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1661189

DOI=10.3389/fcvm.2025.1661189

ISSN=2297-055X

ABSTRACT=BackgroundTreatment strategies for multivessel coronary artery disease (MV-CAD) include percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), and the increasingly adopted hybrid coronary revascularization (HCR). HCR combines minimally invasive left internal mammary artery (LIMA)–to–left anterior descending (LAD) grafting with PCI of non-LAD lesions. However, comparative evidence in high-risk MV-CAD remains limited.MethodsWe retrospectively analyzed 330 high-risk MV-CAD patients from two centers (HCR n = 109; PCI n = 221) over 2 years. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE: all-cause death, stroke, myocardial infarction, repeat revascularization, and angina). Kaplan–Meier survival analysis and conventional statistical tests were applied.ResultsBaseline demographics and SYNTAX scores were similar between groups. HCR involved fewer and shorter stents than PCI. Hospital stay, ICU duration, and total costs were higher with HCR. At 2 years, angina (5.5% vs. 17.2%; P = 0.003) and MACCE (12.8% vs. 23.5%; P = 0.02) were lower with HCR; overall survival by Kaplan–Meier favored HCR (log-rank P = 0.0006).ConclusionsDespite longer hospitalization and higher costs, HCR was associated with superior long-term symptom relief and lower MACCE compared with PCI in high-risk MV-CAD. These findings support HCR as a viable strategy in carefully selected patients and warrant validation in prospective multicenter studies.