AUTHOR=Yang Guoshu , Xiong Shiqiang , Luo Yan , Luo Duan , Shehata Michael , Zhang Zhen , Cai Lin , Wang Xunzhang , Ehdaie Ashkan , Liu Hanxiong 

TITLE=The relative voltage index: a novel tailored method to identify left atrial low voltage areas in non-paroxysmal AF

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1656983

DOI=10.3389/fcvm.2025.1656983

ISSN=2297-055X

ABSTRACT=BackgroundThe optimal voltage threshold for determining low voltage areas (LVA) in non-paroxysmal atrial fibrillation (NPAF) is unclear. This study aims to evaluate a patient-specific voltage measurement using the left atrial appendage (LAA) as a benchmark to establish a normalized threshold for detecting LVA in NPAF.MethodsBipolar LA and LAA voltage in 40 NPAF and 42 patients with no AF (control group) were studied in sinus rhythm (SR) and AF (NPAF group) and SR only in the control group. Bipolar LA and LAA voltage distribution were compared between the NPAF and control groups. Fibrotic regions identified by late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) was used as the reference standard comparison in the NPAF group.ResultsThe median, 5th percentile (VLA5%), and the 95th percentile of bipolar voltage in the LA were significantly lower in NPAF patients than controls. No significant LAA voltage differences between groups [median = 3.303 (1.796) vs. 3.100 (1.045); VLAA95% = 8.089 (3.571) vs. 7.604 (3.404), all p > 0.05]. A strong linear correlation between VLA5% and VLAA95% was observed in the control group. The standardized relative voltage index (RVI) factor of 0.1324 was identified as the threshold for defining LVA and calculated as VLA5% = 0.1324 × VLAA95%. The correlation between LVA guided by RVI was superior to the universal threshold for detecting LVA in sinus and AF rhythms using LGE-MRI as the gold standard.ConclusionA patient-tailored low voltage threshold can be obtained using a simplified equation and provides more accurate representation of LVA in NPAF than universal thresholds.