AUTHOR=Wu Guoxiang , Chen Daqiu , Chen Lifang , Wu Yanqing , Guan Suying , Wu Feng , Chen Yixing , Ye Xianhua , Yang Tao 

TITLE=Influencing factors analysis of clinical effect of heart failure patients treated with ivabradine and metoprolol succinate and construction and validation of nomogram prediction model

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1571468

DOI=10.3389/fcvm.2025.1571468

ISSN=2297-055X

ABSTRACT=ObjectiveTo analyze the influencing factors of the clinical effect of ivabradine (Ivab) combined with metoprolol succinate (Met-S) in patients with heart failure (HF), and to construct and verify the nomogram prediction model, in order to provide reference for clinical treatment.Methods250 cases of HF patients from January 2021 to June 2023 were selected. The relevant factors affecting the therapeutic effect were screened out through univariate and multivariate analysis. The nomogram prediction model was constructed, and the model was verified and evaluated using receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis (DCA).ResultsSingle factor and multiple factor analyses showed that LVEF, LVEDD, 6 MWT, heart rate and BNP level were the independent risk factors for clinical effects (P < 0.05). In the training and testing sets, the area under the ROC curves were 0.862 (95% CI: 0.776–0.947) and 0.819 (95% CI: 0.704–0.934), respectively. The calibration curve showed good consistency, and DCA analysis indicated that the model had clinical application value.ConclusionLVEF, LVEDD, 6 MWT, heart rate and BNP level affect the clinical effect of Ivab combined with Met-S in patients with HF. The nomogram prediction model established has high accuracy and clinical application value.