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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Cardiovasc. Med.</journal-id>
<journal-title>Frontiers in Cardiovascular Medicine</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Cardiovasc. Med.</abbrev-journal-title>
<issn pub-type="epub">2297-055X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fcvm.2024.1409303</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Cardiovascular Medicine</subject>
<subj-group>
<subject>Perspective</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Embracing innovation and advancing care: integrating learning health&#x00A0;system principles into Inova Schar Heart and Vascular</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>O&#x2019;Connor</surname><given-names>Christopher M.</given-names></name>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Rosner</surname><given-names>Carolyn M.</given-names></name>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref><uri xlink:href="https://loop.frontiersin.org/people/2596895/overview"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author"><name><surname>Gill</surname><given-names>Andrew</given-names></name>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author"><name><surname>Speir</surname><given-names>Alan M.</given-names></name>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author"><name><surname>Neville</surname><given-names>Richard F.</given-names></name><uri xlink:href="https://loop.frontiersin.org/people/2595000/overview" />
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
</contrib-group>
<aff><institution>Divisions of Cardiology, Cardiac and Vascular Surgery, Inova Schar Heart and Vascular</institution>, <addr-line>Falls Church, VA</addr-line>, <country>United States</country></aff>
<author-notes>
<fn fn-type="edited-by"><p><bold>Edited by:</bold> Maurice Enriquez-Sarano, Minneapolis Heart Institute Foundation (MHIF), United States</p></fn>
<fn fn-type="edited-by"><p><bold>Reviewed by:</bold> Junjie Xiao, Shanghai University, China</p></fn>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> Carolyn M. Rosner <email>carolyn.rosner@inova.org</email></corresp>
</author-notes>
<pub-date pub-type="epub"><day>24</day><month>10</month><year>2024</year></pub-date>
<pub-date pub-type="collection"><year>2024</year></pub-date>
<volume>11</volume><elocation-id>1409303</elocation-id>
<history>
<date date-type="received"><day>29</day><month>03</month><year>2024</year></date>
<date date-type="accepted"><day>30</day><month>09</month><year>2024</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2024 O&#x0027;Connor, Rosner, Gill, Speir and Neville.</copyright-statement>
<copyright-year>2024</copyright-year><copyright-holder>O&#x0027;Connor, Rosner, Gill, Speir and Neville</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<p>Inova Schar Heart and Vascular has an unwavering commitment to delivering excellent cardiovascular care and has integrated principles of a learning health care system to develop our system of continuous process improvement and innovation. A learning health system integrates its internal experiences with external research to enhance patient outcomes, support the discovery of new treatments and care pathways, and deliver safer, more efficient, and more personalized care. Leveraging learning across health systems maximizes the impact, allowing cardiovascular teams to gain insights into the effectiveness of different treatment strategies. In this Frontiers in Cardiovascular Medicine compendium of articles, the team at Inova describe the spectrum of research and educational activities that have contributed to our progress as a learning cardiovascular health system and support our journey to deliver excellent cardiovascular care.</p>
</abstract>
<kwd-group>
<kwd>innovation</kwd>
<kwd>learning health care system</kwd>
<kwd>cardiovascular care and outcomes</kwd>
<kwd>systems of care</kwd>
<kwd>integration of care</kwd>
</kwd-group><counts>
<fig-count count="1"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="15"/>
<page-count count="4"/>
<word-count count="0"/></counts><custom-meta-wrap><custom-meta><meta-name>section-at-acceptance</meta-name><meta-value>General Cardiovascular Medicine</meta-value></custom-meta></custom-meta-wrap>
</article-meta>
</front>
<body>
<p>Inova Schar Heart and Vascular has an unwavering commitment to delivering excellent cardiovascular care and has integrated principles of a learning health care system to develop our system of continuous process improvement and innovation.</p>
<p>A learning health system integrates its internal experiences with external research to enhance patient outcomes, support the discovery of new treatments and care pathways, and deliver safer, more efficient, and more personalized care (<xref ref-type="bibr" rid="B1">1</xref>). The National Academy of Medicine has extensively studied learning health systems and identified several key benefits, including enabling the collection and utilization of data on a large scale to analyze trends and patterns in cardiovascular diseases. This learning can lead to the identification of specific risk factors, early detection of disease or patterns of deterioration of clinical conditions, and ultimately the development of preventative or mitigating strategies.</p>
<p>Leveraging learning across health systems maximizes the impact, allowing cardiovascular teams to gain insights into the effectiveness of different treatment strategies. The collaborative sharing of best practices, evidence-based guidelines, and research findings through presentations and publications fosters continued innovation and adoption of new technologies, ultimately improving the quality of care provided to patients (<xref ref-type="bibr" rid="B1">1</xref>&#x2013;<xref ref-type="bibr" rid="B3">3</xref>) (<xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref>).</p>
<fig id="F1" position="float"><label>Figure 1</label>
<caption><p>Inova schar heart and vascular integrated learning health care system. Illustrated by Devon Stuart (2024).</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fcvm-11-1409303-g001.tif"/>
</fig>
<p>A culture of research and education within a learning health system environment supports a drive to excellence summarized in this <italic>Frontiers in Cardiovascular Medicine</italic> compendium of articles. Our team members describe the spectrum of research and educational activities that have contributed to our progress as a learning cardiovascular health system and support our journey to deliver excellent care. A few examples of learning health system projects that have been implemented at Inova Schar Heart and Vascular include:
<list list-type="simple">
<list-item><label>&#x2022;</label>
<p>The Inova Cardiogenic Shock Program, developed to address the high mortality seen in patients in Northern Virginia presenting with cardiogenic shock (CS) due to heart attack and heart failure, has used the data collected in the Inova Shock Registry to identify key opportunities for care transformation and developed processes to optimize care delivery, reduce variation, and improve outcomes. Hospitals within and outside the health system adopted our standardized clinical care pathways for identification and management of CS and as patients with CS were cared for and data was added to the registry, the team was able to identify additional important factors, such as unique shock etiologies and disparities in care, associated with higher mortality (<xref ref-type="bibr" rid="B4">4</xref>, <xref ref-type="bibr" rid="B5">5</xref>). This focus has resulted in improved survival for many patients with CS and our experience developing and sustaining a protocol-based approach to CS care is discussed by Mehta, Sinha, et al. in this special compendium of articles (<xref ref-type="bibr" rid="B6">6</xref>).</p></list-item>
<list-item><label>&#x2022;</label>
<p>Similarly, protocols developed to streamline the management of aortic emergencies (ruptured aneurysms and dissections) brought together key stakeholders across the health system, including patient transport, emergency services, the operating room, the catheterization lab, nursing, residents, and multidisciplinary attending staff and resulted in standardized care, improved efficiency and importantly, saved lives in this high-risk population. The process and outcomes are regularly evaluated and discussed at scheduled debriefing sessions to encourage ongoing process improvement.</p></list-item>
<list-item><label>&#x2022;</label>
<p>Another example of learning arising from registry participation is in our vascular surgery program, which utilized important benchmarking information from the Vascular Quality Initiative (VQI) registry to improve carotid endarterectomy outcomes by reducing operator variation, particularly among those with low volumes (<xref ref-type="bibr" rid="B7">7</xref>).</p></list-item>
<list-item><label>&#x2022;</label>
<p>Inova Schar Heart and Vascular was also a founding member and leader in the Virginia Cardiac Services Quality Initiative, a consortium of 18 Virginia Hospitals and 14 cardiac surgical practices and cardiology specialties formed with the goal of improving the outcomes and value of cardiac procedures in the state of Virginia through sharing and reviewing data to learn and implement best practices. One of the important initiatives that came from this was development of new protocols which allowed the Inova team to reduce the blood transfusion needs of patients undergoing bypass surgery without compromising clinical outcomes (<xref ref-type="bibr" rid="B8">8</xref>).</p></list-item>
<list-item><label>&#x2022;</label>
<p>Training programs enhance lifelong learning and the development of our cardiovascular fellowship program facilitated expanding knowledge in both learners and providers and led to improved clinical outcomes in the Cardiac Intensive Care unit. Our cardiology fellows are integral members of the multidisciplinary CV teams and have led and participated in many of the contributions included in this publication (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B9">9</xref>&#x2013;<xref ref-type="bibr" rid="B11">11</xref>).</p></list-item>
<list-item><label>&#x2022;</label>
<p>Engaging all clinicians is an essential step as a learning health care system focused on delivering excellent cardiovascular care, and Advanced Practice Providers (APPs) lead several of our key initiatives, including an outpatient urgent heart failure clinic (UHFC) (<xref ref-type="bibr" rid="B12">12</xref>). The UHFC provides IV diuretics and is a critical part of a successful system of care for the ambulatory management of decompensated heart failure, described in this collection (<xref ref-type="bibr" rid="B13">13</xref>).</p></list-item>
<list-item><label>&#x2022;</label>
<p>Equipping clinicians for leadership roles through the development and implementation of an integrated leadership training academy for physicians and APPs has been another key initiative that yielded increased engagement and effectiveness needed in a learning health system and led to greater leadership responsibility (<xref ref-type="bibr" rid="B14">14</xref>).</p></list-item>
<list-item><label>&#x2022;</label>
<p>The &#x201C;Heart Failure Collaboratory&#x201D; is a public-private partnership developed between Inova Schar Heart and Vascular and the U.S. Food and Drug Administration (FDA) and brings stakeholders together to rethink both the development and implementation of clinical research for patients with heart failure, including strategies to encourage increased utilization of guideline based medical therapy (<xref ref-type="bibr" rid="B11">11</xref>). Inova aspires to be a leader in this by developing electronic health record-based strategies to engage clinicians to utilize guideline-based treatment for their patients with heart failure, via strategic prompts aimed at increasing appropriate medication prescription and referral for advanced heart failure, structural heart and electrophysiology care (<xref ref-type="bibr" rid="B15">15</xref>).</p></list-item>
</list>FDA Commissioner Dr. Robert Califf has highlighted the significance of learning health systems and in his writings, he emphasizes the need to bridge the gap between clinical research and practice. By integrating research into routine clinical care, cardiovascular health systems can generate real-world evidence, which can be used to inform treatment decisions and improve patient outcomes (<xref ref-type="bibr" rid="B15">15</xref>).</p>
<p>In summary, learning health system principles promote the integration of research, practice, and data analysis and elevate clinical care and outcomes. (<xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref>) This integration can lead to the discovery of new treatments and protocols, provide more personalized care, and facilitate excellent cardiovascular care and patient outcomes.</p>
<p>The main concepts of the Integrated Learning Health Care System at Inova Schar Heart and Vascular, with integration of research, registries and guidelines to inform, develop and implement strategies to deliver excellent cardiovascular care and outcomes.</p>
</body>
<back>
<sec id="s2" sec-type="data-availability"><title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec id="s3" sec-type="author-contributions"><title>Author contributions</title>
<p>CO: Writing &#x2013; review &#x0026; editing. CR: Writing &#x2013; review &#x0026; editing. AG: Writing &#x2013; review &#x0026; editing. AS: Writing &#x2013; review &#x0026; editing. RN: Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec id="s4" sec-type="funding-information"><title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<ack><title>Acknowledgment</title>
<p>We would like to thank Dwight and Martha Schar for their generous support of Inova Schar Heart and Vascular, and the Dudley Family for their continued contributions and support of the Inova Dudley Family Center for Cardiovascular Innovation. We also thank the D&#x2019;Aniello family for their support of the Atrial Fibrillation Program, and Lola Reinsch for her family&#x0027;s support of the Inova Reinsch Pierce Cardiomyopathy Program, and Devon Stuart for her illustration of the concepts of this publication.</p>
</ack>
<sec id="s5" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
<p>The handling editor LC declared a past co-authorship/collaboration with the authors CO, CR.</p>
</sec>
<sec id="s6" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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