AUTHOR=Zhao Zhenyu , Wu Shaohui , He Xiaoyan , Zhang Yan , Chen Xuemei , Tang Jie 

TITLE=Autologous platelet-rich gel for refractory plantar ulcer following ethanol sclerotherapy of peripheral venous malformation: a Case Report

JOURNAL=Frontiers in Bioengineering and Biotechnology

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1700377

DOI=10.3389/fbioe.2025.1700377

ISSN=2296-4185

ABSTRACT=Platelet-rich plasma (PRP) contains a high concentration of growth factors that promote angiogenesis, granulation-tissue formation and re-epithelialization, thereby significantly accelerating wound healing. Autologous platelet-rich gel (APG), a gelled form of PRP, provides a sustained release of these factors within a fibrin scaffold. We report a 25-year-old woman who developed a refractory plantar ulcer with tendon exposure after combined absolute-ethanol sclerotherapy and surgical excision of a congenital venous malformation of the left foot. Reflux of the sclerosant produced microcirculatory compromise, followed by full-thickness skin necrosis. Because the plantar skin is under high tension and has a relatively poor blood supply, conventional skin grafting was deemed unlikely to succeed. APG was therefore employed as a salvage treatment. After three applications, the ulcer area had decreased by 95%, and complete epithelialization was achieved within 1 month without scar contracture. Both functional and cosmetic outcomes were excellent. This case illustrates that APG promotes granulation and re-epithelialization of intractable ulcers following sclerotherapy for venous malformations, which reducing the need for grafting and representing a valuable adjunct for wounds with tendon exposure and compromised perfusion.