AUTHOR=Fu Ziyue , Chen Ling , Mo Lingjiang , Zhan Yuefu , Ma Liheng 
  
TITLE=Cerium oxide nanoparticles for enhanced healing of diabetic foot ulcers
  
JOURNAL=Frontiers in Bioengineering and Biotechnology
  
VOLUME=Volume 13 - 2025
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1695821
  
DOI=10.3389/fbioe.2025.1695821
  
ISSN=2296-4185
  
ABSTRACT=One of the main complications of diabetes is diabetic foot ulcers (DFUs), which have a substantial global impact on morbidity, medical expenses, and lower limb amputations. A complicated microenvironment—characterized by bacterial infections, chronic inflammation, oxidative stress, and poor angiogenesis impedes the healing process of DFUs. Cerium oxide nanoparticles (CeO2 nanoparticles), owing to their antibacterial, anti-inflammatory, and antioxidant properties, have emerged as a promising treatment. These nanoparticles can scavenge reactive oxygen species (ROS), reduce inflammation, and stimulate tissue regeneration by modulating macrophage polarization and promoting angiogenesis. However, limitations such as poor biocompatibility, aggregation, and dose-dependent toxicity hinder their clinical application. Recent advances in coating strategies—including polymeric, natural biomolecule, and hybrid coatings have improved the stability, targeting, and controlled release of CeO2 nanoparticles. This review discusses the design, therapeutic mechanisms, and safety considerations of coated CeO2 nanoparticles in DFU treatment, with emphasis on combination therapies and smart-responsive coatings. Clinical translation challenges and future research directions are also addressed.