AUTHOR=Lin Wen-qing , Liu Da , Zhou Renbin , Lin Hao , Zeng Bang , Jia Jun , Zhao Yifang , Liu Bing , Wu Tianfu TITLE=Can titanium miniplates provide superior fixation compared to reconstruction plates in mandibular repair with iliac crest flaps? A retrospective study JOURNAL=Frontiers in Bioengineering and Biotechnology VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1688458 DOI=10.3389/fbioe.2025.1688458 ISSN=2296-4185 ABSTRACT=This study retrospectively analyzed 112 patients who underwent mandibular reconstruction with vascularized iliac crest flaps using different fixation strategies in routine clinical practice. Under comparable defect lengths and heights, reconstruction using mini plates was associated with the shortest operative time (p < 0.001), while postoperative drainage duration showed no significant difference among groups (p = 0.958). The number of iliac bone segments varied significantly among fixation methods: reconstruction plates (alone or combined with mini plates) were predominantly applied in multi-segmental reconstructions, whereas mini plates were mainly used for single-segmental repairs. Postoperative quality of life was evaluated using the University of Washington Quality of Life Questionnaire (UW-QoL). Although the fixation methods were selected according to defect complexity and surgical requirements, all approaches achieved satisfactory outcomes, and no significant difference in overall quality-of-life scores was observed among the three groups (p = 0.354). However, a significant difference was observed in the “Swallowing” domain, with patients in the mini plate group reporting better swallowing function (p = 0.009).