AUTHOR=Khouqeer Ghada A. , Pathak Ranjeet Kumar , AbdelAll Naglaa , Roy Sandip Kumar , Sharan Preeta , Upadhyaya Anup M. 
  
TITLE=Harnessing the power of ANN for early detection and prediction of oral cancer
  
JOURNAL=Frontiers in Artificial Intelligence
  
VOLUME=Volume 9 - 2026
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2026.1723566
  
DOI=10.3389/frai.2026.1723566
  
ISSN=2624-8212
  
ABSTRACT=IntroductionOral cancer affects millions of people worldwide, and early detection significantly improves treatment outcomes and survival rates. Conventional diagnostic approaches often face challenges related to subjectivity and delayed identification. In this context, artificial intelligence–based tools offer promising opportunities for rapid and reliable early screening.MethodsThis study investigates the feasibility of using an Artificial Neural Network (ANN) to predict oral cancer risk based on optical refractive index (RI) features. RI data corresponding to reported INOK (normal oral cells) and YD-10B (oral cancer cells) cell lines were employed. To enhance model robustness and assess feasibility, the dataset was synthetically augmented. Multiple ANN architectures and hyperparameter configurations were systematically evaluated to identify the optimal network topology for classification.ResultsThe optimized ANN model demonstrated excellent performance in distinguishing between normal and oral cancer cell data. A precision score of 98.72% indicates that nearly all samples classified as cancerous were truly positive, minimizing false-positive predictions. Additionally, the model achieved a specificity of 99.00%, highlighting its strong capability to correctly identify non-cancerous cases.Discussion and conclusionThe high precision and specificity values underscore the effectiveness of ANN-based classification using optical refractive index features for oral cancer screening. By reducing false positives and preventing unnecessary anxiety among healthy individuals, the proposed approach offers significant clinical value. These findings demonstrate the potential of ANN-assisted optical analysis as a reliable and efficient tool for early oral cancer detection, paving the way for faster diagnosis and improved patient outcomes.