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<journal-id journal-id-type="publisher-id">Front. Artif. Intell.</journal-id>
<journal-title>Frontiers in Artificial Intelligence</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Artif. Intell.</abbrev-journal-title>
<issn pub-type="epub">2624-8212</issn>
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<publisher-name>Frontiers Media S.A.</publisher-name>
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<article-id pub-id-type="doi">10.3389/frai.2024.1464690</article-id>
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<subj-group subj-group-type="heading">
<subject>Artificial Intelligence</subject>
<subj-group>
<subject>Perspective</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Fostering effective hybrid human-LLM reasoning and decision making</article-title>
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<contrib contrib-type="author" corresp="yes">
<name><surname>Passerini</surname> <given-names>Andrea</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
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<name><surname>Gema</surname> <given-names>Aryo</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
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<name><surname>Minervini</surname> <given-names>Pasquale</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
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<name><surname>Sayin</surname> <given-names>Burcu</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
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<name><surname>Tentori</surname> <given-names>Katya</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
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<aff id="aff1"><sup>1</sup><institution>Department of Information Engineering and Computer Science, University of Trento</institution>, <addr-line>Trento</addr-line>, <country>Italy</country></aff>
<aff id="aff2"><sup>2</sup><institution>School of Informatics, University of Edinburgh</institution>, <addr-line>Edinburgh</addr-line>, <country>United Kingdom</country></aff>
<aff id="aff3"><sup>3</sup><institution>Center for Mind/Brain Sciences, University of Trento</institution>, <addr-line>Trento</addr-line>, <country>Italy</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Pradeep K. Murukannaiah, Delft University of Technology, Netherlands</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Michiel Van Der Meer, Idiap Research Institute, Switzerland</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Andrea Passerini <email>andrea.passerini&#x00040;unitn.it</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>08</day>
<month>01</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>7</volume>
<elocation-id>1464690</elocation-id>
<history>
<date date-type="received">
<day>14</day>
<month>07</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>19</day>
<month>12</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2025 Passerini, Gema, Minervini, Sayin and Tentori.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Passerini, Gema, Minervini, Sayin and Tentori</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<p>The impressive performance of modern Large Language Models (LLMs) across a wide range of tasks, along with their often non-trivial errors, has garnered unprecedented attention regarding the potential of AI and its impact on everyday life. While considerable effort has been and continues to be dedicated to overcoming the limitations of current models, the potentials and risks of human-LLM collaboration remain largely underexplored. In this perspective, we argue that enhancing the focus on human-LLM interaction should be a primary target for future LLM research. Specifically, we will briefly examine some of the biases that may hinder effective collaboration between humans and machines, explore potential solutions, and discuss two broader goals&#x02014;mutual understanding and complementary team performance&#x02014;that, in our view, future research should address to enhance effective human-LLM reasoning and decision-making.</p></abstract>
<kwd-group>
<kwd>hybrid intelligence</kwd>
<kwd>human-AI collaboration</kwd>
<kwd>LLMs</kwd>
<kwd>biases</kwd>
<kwd>mutual understanding</kwd>
<kwd>complementary team performance</kwd>
</kwd-group>
<contract-sponsor id="cn001">HORIZON EUROPE Framework Programme<named-content content-type="fundref-id">10.13039/100018693</named-content></contract-sponsor>
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<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Machine Learning and Artificial Intelligence</meta-value>
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</front>
<body>
<sec sec-type="intro" id="s1">
<title>1 Introduction</title>
<p>The release of chatGPT has raised unprecedented attention and generated high expectations on the capabilities of AI systems that leverage large language model (LLM) technologies. These systems have demonstrated impressive results across a wide range of tasks (Liu et al., <xref ref-type="bibr" rid="B94">2023b</xref>; Yang et al., <xref ref-type="bibr" rid="B165">2024</xref>), such as language translation (Jiao et al., <xref ref-type="bibr" rid="B71">2023</xref>), text summarization (Pu and Demberg, <xref ref-type="bibr" rid="B119">2023</xref>), question-answering (Bahak et al., <xref ref-type="bibr" rid="B7">2023</xref>), reasoning (Bang et al., <xref ref-type="bibr" rid="B9">2023</xref>), and text generation (Chen et al., <xref ref-type="bibr" rid="B29">2023b</xref>; Jeblick et al., <xref ref-type="bibr" rid="B68">2022</xref>), prompting questions about the potential emergence of &#x0201C;thinking machines&#x0201D; and artificial general intelligence sparks (Bubeck et al., <xref ref-type="bibr" rid="B19">2023</xref>). However, several studies have highlighted the limitations of these systems. Just to provide a few examples, they have been shown to provide entirely fabricated information (Huang et al., <xref ref-type="bibr" rid="B65">2023</xref>), to exhibit sensitivity to small changes in the way questions are posed (Pezeshkpour and Hruschka, <xref ref-type="bibr" rid="B117">2023</xref>), and to agree with human opinions regardless of content (Sharma et al., <xref ref-type="bibr" rid="B130">2023</xref>).</p>
<p>Human beings are also far from being entirely rational, and not in an obvious way. The deviations of human reasoning from normative benchmarks create an intriguing puzzle that is not yet completely understood in Cognitive Science. On the one hand, systematic and persistent biases manifest even in well-motivated and expert individuals engaged in simple, high-stakes probability tasks (Baron, <xref ref-type="bibr" rid="B12">2023</xref>). This suggests that reasoning errors do not stem from carelessness, computational limitations, or lack of education, nor are they necessarily caused by &#x0201C;external constraints&#x0201D; such as inadequate information or time pressure. On the other hand, individuals are often capable of complex inferences (Tenenbaum et al., <xref ref-type="bibr" rid="B138">2011</xref>; Mastropasqua et al., <xref ref-type="bibr" rid="B103">2010</xref>). In particular, evidential reasoning&#x02014;i.e., the assessments of the perceived impact of evidence&#x02014;appears to be quite effective, demonstrating greater accuracy and consistency over time compared to corresponding posterior probability judgments (Tentori et al., <xref ref-type="bibr" rid="B139">2016</xref>). This holds true even though, from a formal standpoint, calculating the former is no easier than calculating the latter.</p>
<p>Notably, there are solid reasons to believe that neither LLM-based AI systems nor humans will turn into completely rational agents anytime soon. With regard to the former, the inherent mechanisms of LLMs impose significant constraints on their capabilities. Bender and Koller (<xref ref-type="bibr" rid="B14">2020</xref>) and Bender et al. (<xref ref-type="bibr" rid="B13">2021</xref>) coined the term &#x0201C;stochastic parrots&#x0201D; to highlight the fact that LLMs focus on form over meaning and stressed the difficulty of getting the latter from the former. More recently, Mahowald et al. (<xref ref-type="bibr" rid="B100">2024</xref>) formalized the problem in terms of the distinction between formal and functional linguistic competence, arguing that LLM architectures require substantial modifications to have a chance of achieving the latter. Finally, Xu et al. (<xref ref-type="bibr" rid="B164">2024b</xref>) indicated that inconsistencies between LLMs and the real world are, to some extent, inevitable. In a similar vein, efforts to enhance human rationality by using visual aids (Khan et al., <xref ref-type="bibr" rid="B75">2015</xref>), promoting accountability (e.g., Boissin et al., <xref ref-type="bibr" rid="B18">2023</xref>), or shaping external environments (e.g., <italic>nudging</italic>, Thaler and Sunstein, <xref ref-type="bibr" rid="B142">2009</xref>) have often yielded modest results that are not easily generalizable to other contexts (Chater and Loewenstein, <xref ref-type="bibr" rid="B26">2023</xref>). The limited effectiveness of these interventions suggests that the causes of reasoning biases are deeply ingrained in our cognitive processes, and we cannot expect to eradicate them, at least not in the near future.</p>
<p>Humans and LLMs are not only imperfect yet highly capable, but they also differ significantly in their respective strengths and weaknesses (Chang et al., <xref ref-type="bibr" rid="B25">2023</xref>; Shen et al., <xref ref-type="bibr" rid="B131">2023</xref>; Felin and Holweg, <xref ref-type="bibr" rid="B48">2024</xref>; Leivada et al., <xref ref-type="bibr" rid="B81">2024</xref>). Thus, while mere interaction between the two does not guarantee success, a carefully designed human-LLM synergy has the potential to prevent critical problems and achieve results that surpass what either could accomplish alone. Indeed, recent research highlights human-LLM collaboration as a key direction toward realizing genuinely human-centered AI. (Dellermann et al., <xref ref-type="bibr" rid="B38">2019</xref>; Akata et al., <xref ref-type="bibr" rid="B1">2020</xref>; Lawrence, <xref ref-type="bibr" rid="B79">2024</xref>; Wang et al., <xref ref-type="bibr" rid="B151">2024</xref>; Ma et al., <xref ref-type="bibr" rid="B98">2024</xref>; Liao and Wortman Vaughan, <xref ref-type="bibr" rid="B88">2024</xref>). However, in our view, effectively addressing this issue necessitates a significant shift in perspective. The primary challenge we must confront&#x02014;and one that will increasingly be faced in the future&#x02014;lies not so much in the specific boundaries of human rationality or the current technological limitation of LLMs, but rather in the nature and severity of biases that can arise from their <italic>interaction</italic>. For this reason, we do not aim to provide an exhaustive list of the many cognitive biases that individuals&#x02014;and, in some cases, LLMs&#x02014;exhibit. Instead, we will focus on three major problems of LLMs&#x02014;<italic>hallucinations, inconsistencies</italic> and <italic>sycophancy</italic>&#x02014;demonstrating how they can impact the interplay with humans. We will then discuss two key desiderata, <italic>mutual understanding</italic> and <italic>complementary team performance</italic>, which, in our opinion, future research should address more comprehensively to foster effective human-LLM reasoning and decision-making.</p>
</sec>
<sec id="s2">
<title>2 Potential weaknesses in human-LLM interaction</title>
<p>One of the most well-known problems of LLMs is hallucination, which refers to their distinct possibility of generating outputs that do not align with factual reality or the input context (Huang et al., <xref ref-type="bibr" rid="B65">2023</xref>). Hallucinations in LLMs have several causes, from flawed data sources (Lin et al., <xref ref-type="bibr" rid="B90">2022b</xref>) to architectural biases (Li et al., <xref ref-type="bibr" rid="B86">2023b</xref>; Liu et al., <xref ref-type="bibr" rid="B92">2023a</xref>). To exacerbate the issue, when LLMs engage in hallucination, they maintain an aura of authority and credibility by generating responses that appear coherent and well-formed in terms of natural language structure (Berberette et al., <xref ref-type="bibr" rid="B15">2024</xref>; Su et al., <xref ref-type="bibr" rid="B136">2024</xref>). Such a behavior can easily lead to an <italic>automation bias</italic> (Cummings, <xref ref-type="bibr" rid="B37">2012</xref>), where users tend to over-rely on information and suggestions from automated systems compared to those from their peers. Indeed, while people can easily detect nonsensical or blatantly unrelated outputs from LLMs when they have a good knowledge of the topic, they are more likely to overlook such errors when they lack expertise in the subject. This creates a paradox: one must already possess the correct answer to reliably avoid being misled by LLMs. Nonetheless, expertise itself is not a guarantee that everything will go smoothly. Humans, including professionals such as, for example, physicians, often exhibit a tendency known as <italic>overconfidence</italic> (Hoffrage, <xref ref-type="bibr" rid="B62">2022</xref>), where they tend to overestimate their abilities or the accuracy of their knowledge. Predicting which of these somewhat opposite attitudes would prevail in a given interaction between humans and LLMs is extremely difficult. LLMs could, in principle, counteract overconfidence by providing negative feedback to users. However, what might seem like an easy solution runs into another characteristic of these systems: their tendency toward sycophancy, which is the inclination to please users by generating responses that are agreeable rather than strictly accurate, especially when trained with biased human feedback or tasked with generating content in subjective domains (Sharma et al., <xref ref-type="bibr" rid="B130">2023</xref>; Ranaldi and Pucci, <xref ref-type="bibr" rid="B121">2023</xref>; Wei et al., <xref ref-type="bibr" rid="B157">2023</xref>). Furthermore, overly critical feedback may lead to <italic>algorithm aversion bias</italic> (Dietvorst et al., <xref ref-type="bibr" rid="B41">2014</xref>), where users disregard information that conflicts with their previous beliefs, even when it is actually pertinent and correct. This bias reflects the skepticism with which humans&#x02014;especially professionals in high-stakes fields like healthcare and law, where accountability is paramount&#x02014;often view the advanced capabilities of LLMs (Park et al., <xref ref-type="bibr" rid="B114">2023</xref>; Cheong et al., <xref ref-type="bibr" rid="B31">2024</xref>; Choudhury and Chaudhry, <xref ref-type="bibr" rid="B33">2024</xref>; Eigner and H&#x000E4;ndler, <xref ref-type="bibr" rid="B44">2024</xref>; Watters and Lemanski, <xref ref-type="bibr" rid="B156">2023</xref>). Additionally, algorithm aversion may be fueled by a loss of confidence following unsatisfactory initial interactions (Huang et al., <xref ref-type="bibr" rid="B66">2024</xref>; McGrath et al., <xref ref-type="bibr" rid="B105">2024</xref>). In particular, LLM inconsistency&#x02014;reflected in their tendency to produce varying outputs for very similar (or even identical) inputs&#x02014;can easily leave lasting impressions of unreliability. This issue is exacerbated by high prompt sensitivity, where the LLM tend to provide different answers even with slight changes in how questions are phrased (Pezeshkpour and Hruschka, <xref ref-type="bibr" rid="B117">2023</xref>; Voronov et al., <xref ref-type="bibr" rid="B149">2024</xref>; Mao et al., <xref ref-type="bibr" rid="B102">2024</xref>; Sayin et al., <xref ref-type="bibr" rid="B126">2024</xref>). As a consequence, individuals may become increasingly reluctant to utilize LLMs when confronted with important reasoning and decision-making tasks.</p>
<p>Let us now consider a situation that, in principle, would be expected to unfold more smoothly&#x02014;namely, one in which neither LLMs nor humans are outright incorrect. It might be assumed that accuracy alone would suffice to prevent errors; however, unfortunately, this is not necessarily the case. A well-known bias that could persist or even intensify in interactions where humans feel competent and LLMs provide reliable evidence is <italic>confirmation bias</italic>: the tendency to selectively seek, interpret, and recall information that supports existing beliefs (Nickerson, <xref ref-type="bibr" rid="B112">1998</xref>). Indeed, when users query LLMs based on initial hypotheses and the models provide selective answers mainly based on local context, a vicious cycle can be fueled. A closely related cognitive bias that may similarly be exacerbated in interactions with LLMs is <italic>belief bias</italic>, that is the tendency to conflate the validity of an argument with the confidence placed in its conclusion (Evans et al., <xref ref-type="bibr" rid="B47">1983</xref>). For instance, users might fail to realize that evidence obtained too easily, thanks to the &#x0201C;efficiency&#x0201D; of LLMs in supporting a cherished hypothesis, is not as comprehensive or conclusive with respect to the hypothesis in question as it may seem. Another risk is <italic>overestimating redundant information</italic>: without full control over the sources LLMs draw from, users may overlook redundancy and mistakenly believe they are gaining new evidence to support a particular belief or prediction, when in fact they are not (Bohren, <xref ref-type="bibr" rid="B17">2016</xref>). Similarly, interactions between individuals and LLMs might be susceptible to the so-called <italic>anchoring</italic> to initial hypotheses or inquiries (Tversky and Kahneman, <xref ref-type="bibr" rid="B144">1974</xref>), as well as to <italic>order effects</italic> (Hogarth and Einhorn, <xref ref-type="bibr" rid="B63">1992</xref>). These biases refer, respectively, to the tendency to rely excessively on reference points (even if irrelevant) when making estimates, and to assign greater importance to, or better recall, the first or last pieces of information encountered, at the expense of less available content.</p>
<p>Ex-post evaluation of interactions between human reasoners and LLMs (i.e., the assessment of their interactions after they have taken place) is not immune to errors either. Among the major issues, one cannot help but consider the well-known <italic>hindsight bias</italic>, which is the tendency to perceive events, once they have occurred, as more predictable than they actually were (Arkes, <xref ref-type="bibr" rid="B6">2013</xref>). For instance, individuals might overestimate the accuracy of LLM predictions simply because they overlook how often the original outputs of these models are tentative and inconclusive. Similarly, due to the selective information provided by the models, individuals may underestimate their own initial uncertainties. The concern is that if this misinterpretation of the interaction occurs collaboratively, biases like the one discussed above could be reinforced rather than mitigated.</p>
<p>In conclusion, interactions between the LLM and the user can amplify their inherent weaknesses or even create new ones. This underscores the urgent need for methodological innovations that integrate LLM behaviors with new, interactively designed solutions; without this, they may fail or even backfire.</p>
</sec>
<sec id="s3">
<title>3 Toward effective human-LLM interaction</title>
<p>In this section, we will first present potential solutions to three major challenges of LLMs: hallucinations, inconsistencies, and sycophancy. We will then discuss how fostering mutual understanding and enhancing complementary team performance are crucial for achieving effective collaboration in reasoning and decision-making between humans and LLMs.</p>
<sec>
<title>3.1 Detecting and mitigating the impact of hallucinations</title>
<p>Hallucinations are extensively studied in the field of Natural Language Processing (NLP), with various approaches proposed to prevent, detect, or mitigate their occurrence (Huang et al., <xref ref-type="bibr" rid="B65">2023</xref>; Ji et al., <xref ref-type="bibr" rid="B69">2023a</xref>; Rawte et al., <xref ref-type="bibr" rid="B122">2023</xref>; Zhang et al., <xref ref-type="bibr" rid="B167">2023</xref>). Following Huang et al. (<xref ref-type="bibr" rid="B65">2023</xref>), we categorize hallucinations into <italic>factuality hallucinations</italic>, where the model generates responses that contradict real-world facts, and <italic>faithfulness hallucinations</italic>, where the model&#x00027;s responses are not aligned with user instructions or the provided context. The latter can be further divided into <italic>intrinsic hallucinations</italic>, involving responses that directly contradict the context, and <italic>extrinsic hallucinations</italic>, in which the generated content cannot be verified or refuted based on the context (Maynez et al., <xref ref-type="bibr" rid="B104">2020</xref>).</p>
<p>One way to improve the factuality of model-generated content is via <italic>retrieval augmented generation</italic> (Lewis et al., <xref ref-type="bibr" rid="B83">2020</xref>), which conditions the generation process on documents retrieved from a corpus such as Wikipedia or Pubmed (Shuster et al., <xref ref-type="bibr" rid="B133">2021</xref>; Xiong et al., <xref ref-type="bibr" rid="B161">2024</xref>; Zakka et al., <xref ref-type="bibr" rid="B166">2024</xref>). However, LLMs can still disregard provided information and rely on their parametric knowledge due to intrinsic mechanisms (Jin et al., <xref ref-type="bibr" rid="B72">2024</xref>; Xu et al., <xref ref-type="bibr" rid="B163">2024a</xref>) or sensitivity to prompts (Liu et al., <xref ref-type="bibr" rid="B93">2024</xref>). Another solution is adapting the generation process&#x02014;referred to as <italic>decoding</italic>&#x02014;to produce more factual responses (Lee et al., <xref ref-type="bibr" rid="B80">2022</xref>; Burns et al., <xref ref-type="bibr" rid="B21">2023</xref>; Moschella et al., <xref ref-type="bibr" rid="B111">2023</xref>; Li et al., <xref ref-type="bibr" rid="B84">2023a</xref>; Chuang et al., <xref ref-type="bibr" rid="B34">2023</xref>), and post-editing to refine the originally generated content, leveraging the self-correction capabilities of LLMs (Dhuliawala et al., <xref ref-type="bibr" rid="B40">2023</xref>; Ji et al., <xref ref-type="bibr" rid="B70">2023b</xref>). Decoding can also be adapted to generate outputs that are more faithful to the user instructions or the provided context.</p>
<p>Recent efforts to mitigate faithfulness hallucinations focus on two main areas: <italic>context consistency</italic>, which aims to improve the alignment of model-generated responses with user instructions and the provided context (Tian et al., <xref ref-type="bibr" rid="B143">2019</xref>; van der Poel et al., <xref ref-type="bibr" rid="B146">2022</xref>; Wan et al., <xref ref-type="bibr" rid="B150">2023</xref>; Shi et al., <xref ref-type="bibr" rid="B132">2023</xref>; Gema et al., <xref ref-type="bibr" rid="B52">2024</xref>; Zhao et al., <xref ref-type="bibr" rid="B170">2024b</xref>); and <italic>logical consistency</italic>, which seeks to ensure logically coherent responses in multi-step reasoning tasks (Wang et al., <xref ref-type="bibr" rid="B152">2023a</xref>). Decoding-based methods can be coupled with <italic>post-hoc</italic> hallucination detection approaches (Manakul et al., <xref ref-type="bibr" rid="B101">2023</xref>; Min et al., <xref ref-type="bibr" rid="B109">2023</xref>; Mishra et al., <xref ref-type="bibr" rid="B110">2024</xref>) to define a reward model and adaptively increase the likelihood of hallucination-free generations (Wan et al., <xref ref-type="bibr" rid="B150">2023</xref>; Amini et al., <xref ref-type="bibr" rid="B4">2024</xref>; Lu et al., <xref ref-type="bibr" rid="B97">2022</xref>, <xref ref-type="bibr" rid="B96">2023</xref>; Deng and Raffel, <xref ref-type="bibr" rid="B39">2023</xref>). From the user&#x00027;s perspective, a crucial factor in reducing LLM hallucinations is ensuring that queries are well-constructed, unambiguous, and as specific as possible, since vague or poorly phrased prompts can increase the likelihood of hallucinations (Watson and Cho, <xref ref-type="bibr" rid="B155">2024</xref>).</p>
<p>Although the solutions discussed above can help reduce hallucinations, they will remain, to some extent, inevitable due to the complexity of the world that LLMs attempt to capture (Xu et al., <xref ref-type="bibr" rid="B164">2024b</xref>). A complementary approach is to enhance humans&#x00027; awareness in managing such occurrences by enabling LLMs to provide uncertainty estimates alongside their outputs. The approaches implemented so far in this line of research fall into three categories (Xiong et al., <xref ref-type="bibr" rid="B162">2024</xref>): <italic>logit-based estimation, verbalization-based estimation</italic>, and <italic>consistency-based estimation</italic>. Logit-based estimation requires access to the model logits and typically measures uncertainty by calculating token-level probability or entropy (Guo et al., <xref ref-type="bibr" rid="B55">2017</xref>; Kuhn et al., <xref ref-type="bibr" rid="B78">2023</xref>). Verbalize-based estimation works by directly requesting LLMs to express their uncertainty via prompting strategy (Mielke et al., <xref ref-type="bibr" rid="B106">2022</xref>; Lin et al., <xref ref-type="bibr" rid="B89">2022a</xref>; Xiong et al., <xref ref-type="bibr" rid="B162">2024</xref>; Kadavath et al., <xref ref-type="bibr" rid="B74">2022</xref>). Finally, consistency-based estimation works under the assumption that the most consistent response signifies the least hallucination in the LLM generations (Lin et al., <xref ref-type="bibr" rid="B91">2023</xref>; Chen and Mueller, <xref ref-type="bibr" rid="B27">2023</xref>; Wang et al., <xref ref-type="bibr" rid="B153">2023b</xref>; Zhao et al., <xref ref-type="bibr" rid="B169">2023</xref>). Additionally, recent studies are exploring a new and promising strategy in which LLMs learn to generate citations (Gao et al., <xref ref-type="bibr" rid="B50">2023</xref>; Huang and Chang, <xref ref-type="bibr" rid="B64">2023</xref>). In this way, users can assess the reliability of the outputs provided by LLMs by examining, and potentially directly accessing, their sources.</p>
</sec>
<sec>
<title>3.2 Improving robustness</title>
<p>Variability, prompt brittleness, and inconsistencies in LLM outputs across different conditions, domains, and tasks (Gupta et al., <xref ref-type="bibr" rid="B56">2023</xref>; Zhou et al., <xref ref-type="bibr" rid="B172">2024</xref>; Tytarenko and Amin, <xref ref-type="bibr" rid="B145">2024</xref>) pose significant challenges for ensuring effective interaction with humans and can substantially exacerbate their algorithmic aversion. Efforts to enhance the robustness of LLMs have included adjustments during training, as well as <italic>post-hoc</italic> solutions applied after learning has taken place. Regarding the former, recent research has increasingly recognized the value of including domain experts within development teams (e.g., Med-Gemini in healthcare; Saab et al., <xref ref-type="bibr" rid="B125">2024</xref>, FinMA in finance; Xie et al., <xref ref-type="bibr" rid="B159">2023</xref>, and SaulLM; Colombo et al., <xref ref-type="bibr" rid="B35">2024</xref>). Post-training techniques aimed at mitigating prompt sensitivity while preserving performance include <italic>in-context learning adjustments</italic> (Gupta et al., <xref ref-type="bibr" rid="B56">2023</xref>), <italic>task-specific context attribution</italic> (Tytarenko and Amin, <xref ref-type="bibr" rid="B145">2024</xref>), and <italic>batch calibration</italic> (Zhou et al., <xref ref-type="bibr" rid="B172">2024</xref>).</p>
<p>Among the solutions for enhancing LLM robustness are those that directly involve humans, within both perspectives mentioned above. Zhao et al. (<xref ref-type="bibr" rid="B171">2024c</xref>) introduced <italic>consistency alignment training</italic> to better align LLM responses with human expectations, fine-tuning LLMs to provide consistent answers to paraphrased instructions Post-training methods involving humans often focus on improving in-context learning examples to be given to the LLMs, by coupling input-output pairs with their corresponding human-generated natural language explanations (He et al., <xref ref-type="bibr" rid="B58">2024</xref>).</p>
<p>Another approach to increasing robustness involves introducing an intermediate step between the user and the model, known as <italic>guardrailing</italic> (Inan et al., <xref ref-type="bibr" rid="B67">2023</xref>; Rebedea et al., <xref ref-type="bibr" rid="B123">2023</xref>), which literally means &#x00027;keeping the model on track.&#x00027; This step evaluates the input and/or output of LLMs to determine if and how certain enforcement actions should be implemented. Common instances include refraining from providing answers that could lead to misuse or blocking responses that contain harmful, inappropriate, or biased content.</p>
</sec>
<sec>
<title>3.3 Dealing with sycophancy</title>
<p>Sycophancy is a sort of &#x02018;side effect&#x00027; of the attempt to maximize user satisfaction and the training of LLMs on datasets that include texts generated by humans, where interlocutors often seek to meet each other&#x00027;s expectations. This issue with current LLMs is, of course, not independent of other limitations, but they can exacerbate one another. Indeed, LLMs often hallucinate and become inconsistent in order to appease user prompts, especially when these are misleading. By compelling LLMs not to accommodate these prompts, it could thus lead to a reduction of multiple limitations. On this line, Rrv et al. (<xref ref-type="bibr" rid="B124">2024</xref>) showed how popular hallucination mitigation strategies can be effectively used also to reduce the sycophantic behavior of LLMs in factual statement generation.</p>
<p>Other solutions to address sycophancy involve fine-tuning LLMs over aggregated preferences of multiple humans (Sharma et al., <xref ref-type="bibr" rid="B130">2023</xref>), generating synthetic fine-tuning data to change model behavior (Wei et al., <xref ref-type="bibr" rid="B157">2023</xref>) or applying activation editing to steer the internal representations of LLMs toward a less sycophantic direction (Panickssery et al., <xref ref-type="bibr" rid="B113">2024</xref>). To preserve the original capabilities of the LLM as much as possible, Chen et al. (<xref ref-type="bibr" rid="B30">2024</xref>) propose <italic>supervised pinpoint tuning</italic>, where fine-tuning is confined to specific LLM modules identified as responsible for the sycophantic behavior.</p>
<p>Finally, Cai et al. (<xref ref-type="bibr" rid="B22">2024</xref>) proposed a shift in perspective, termed <italic>antagonistic AI</italic>, a provocative counter-narrative to the prevailing trend of designing AI systems to be agreeable and subservient. According to this approach, human-LLM interactions could benefit from confrontational LLMs that challenge users, even to the point of being blunt if necessary. More specifically, the authors argue that forcing users to confront their own assumptions would, at least in certain situations, promote critical thinking. This intriguing proposal has yet to be implemented or undergo empirical testing. Complementary to this, Tessler et al. (<xref ref-type="bibr" rid="B141">2024</xref>) demonstrated that LLMs can assist humans in finding common ground during democratic deliberation by facilitating effective perspective-taking among group members. We believe these approaches could indeed help people identify potential pitfalls in their reasoning and decision-making processes if complemented by cognition-aware interaction strategies to avoid exacerbating algorithmic aversion bias.</p>
</sec>
<sec>
<title>3.4 Fostering mutual understanding</title>
<p>The blossoming area of Explainable AI (XAI; Miller, <xref ref-type="bibr" rid="B108">2018</xref>; Gunning et al., <xref ref-type="bibr" rid="B54">2019</xref>; Longo et al., <xref ref-type="bibr" rid="B95">2024</xref>) aims at addressing the problem of explaining the outputs of black-box models to humans, focusing either on single predictions (<italic>local explainability</italic>) or the entire model (<italic>global explainability</italic>). <italic>Explanatory interactive learning</italic> (Teso and Kersting, <xref ref-type="bibr" rid="B140">2019</xref>) builds upon XAI approaches to allow humans to guide machines in learning meaningful predictive patterns while avoiding confounders and shortcuts. However, XAI faces several challenges, from the lack of faithfulness in the generated explanations (Camburu et al., <xref ref-type="bibr" rid="B23">2019</xref>) to the impact of human cognitive biases on evaluating these explanations (Bertrand et al., <xref ref-type="bibr" rid="B16">2022</xref>), including the risk of increasing automation bias (Bansal et al., <xref ref-type="bibr" rid="B10">2021</xref>; Bu&#x000E7;inca et al., <xref ref-type="bibr" rid="B20">2021</xref>). The opposite direction&#x02014;helping machines to understand humans&#x02014;is equally challenging. Eliciting human knowledge proves inherently difficult, as it is often implicit, incomplete, or incorrect (Patel et al., <xref ref-type="bibr" rid="B115">1999</xref>). Expert judgments, although intuitive, depend on rich mental models that manage incomplete or conflicting information, complicating the representation of this knowledge for machine learning models (Klein et al., <xref ref-type="bibr" rid="B76">2017</xref>; Militello and Anders, <xref ref-type="bibr" rid="B107">2019</xref>).</p>
<p>Compared to other black-box models, LLM-based architectures offer both advantages and disadvantages in terms of mutual understanding. A clear advantage is their use of natural language for communication, enabling conversational sessions where human feedback is integrated into subsequent interactions. However, this natural mode of interaction can be misleading for human partners. Indeed, empirical studies show that users increase their trust in LLM responses when these are accompanied by explanations, even if the responses are deceptive (Sharma et al., <xref ref-type="bibr" rid="B129">2024</xref>). Although various attempts to foster human-LLM alignment through training and interaction strategies have been made (Wang et al., <xref ref-type="bibr" rid="B154">2023c</xref>), LLMs still represent concepts through distributional semantics (Lenci and Sahlgren, <xref ref-type="bibr" rid="B82">2023</xref>), which differs significantly from human semantic understanding (Bender and Koller, <xref ref-type="bibr" rid="B14">2020</xref>). One consequence is that, like many other sub-symbolic machine learning models, LLMs are prone to shortcut learning (Du et al., <xref ref-type="bibr" rid="B43">2023</xref>), a tendency to rely on non-robust features that are spuriously correlated with ground-truth supervision in the training data, yet fail to generalize in out-of-distribution scenarios. XAI approaches are starting to shed light on the reasoning mechanisms of LLMs (Zhao et al., <xref ref-type="bibr" rid="B168">2024a</xref>), but further research is needed for them to produce reliable proxies of the trustworthiness of LLM outputs.</p>
<p>Finally, effective interaction between humans and LLMs requires a form of mutual understanding that involves a theory of mind (ToM; Premack and Woodruff, <xref ref-type="bibr" rid="B118">1978</xref>)&#x02014;the ability to infer what others are thinking and how this differs from our own thoughts, a crucial precondition for effective communication and cooperation. Recent studies (van Duijn et al., <xref ref-type="bibr" rid="B147">2023</xref>; Kosinski, <xref ref-type="bibr" rid="B77">2024</xref>; Strachan et al., <xref ref-type="bibr" rid="B134">2024</xref>) have shown that larger LLMs, such as GPT-4, made significant progress in ToM, performing on par with, and sometimes even surpassing, humans under certain conditions. However, this competence primarily reflects an ability to simulate human-like responses rather than a genuine mastery of the cognitive processes involved in ToM reasoning. Achieving authentic ToM in LLMs will require further advancements, such as leveraging external memory systems (Li and Qiu, <xref ref-type="bibr" rid="B85">2023</xref>; Schuurmans, <xref ref-type="bibr" rid="B128">2023</xref>) and, eventually, developing machine metacognition (Johnson et al., <xref ref-type="bibr" rid="B73">2024</xref>).</p>
</sec>
<sec>
<title>3.5 Targeting complementary team performance</title>
<p>Machine learning methods are typically evaluated in terms of their performance as standalone entities. LLMs are no exceptions to this rule and most research focuses on improving their performance over pre-defined benchmarks (Hendrycks et al., <xref ref-type="bibr" rid="B61">2021</xref>; Liang et al., <xref ref-type="bibr" rid="B87">2022</xref>; Petroni et al., <xref ref-type="bibr" rid="B116">2021</xref>; Chiang et al., <xref ref-type="bibr" rid="B32">2024</xref>). A recent trend has started to question this perspective, advocating for explicit inclusion of the human component in the development and use of these systems (Donahue et al., <xref ref-type="bibr" rid="B42">2022</xref>; Hemmer et al., <xref ref-type="bibr" rid="B60">2021</xref>; Guszcza et al., <xref ref-type="bibr" rid="B57">2022</xref>; Sayin et al., <xref ref-type="bibr" rid="B127">2023</xref>). The notion of <italic>complementary team performance</italic> (CTP; Bansal et al., <xref ref-type="bibr" rid="B10">2021</xref>) has been introduced to evaluate whether team accuracy is higher than either the human or the AI working alone (Hemmer et al., <xref ref-type="bibr" rid="B60">2021</xref>, <xref ref-type="bibr" rid="B59">2024</xref>; Campero et al., <xref ref-type="bibr" rid="B24">2022</xref>). Quite interestingly, studies have shown that human-AI teams can outperform humans but often do not exceed the performance of AI alone (Bansal et al., <xref ref-type="bibr" rid="B10">2021</xref>; Hemmer et al., <xref ref-type="bibr" rid="B60">2021</xref>), highlighting the complexity of achieving good CTP in practice.</p>
<p>Within the machine learning community, researchers have developed <italic>ad hoc</italic> learning strategies to improve CTP. The most popular is <italic>selective classification</italic> (Geifman and El-Yaniv, <xref ref-type="bibr" rid="B51">2017</xref>), where the machine selectively abstains from providing predictions it deems too uncertain. Several selective classification strategies have been proposed in the NLP community, especially in question-answering tasks (Xin et al., <xref ref-type="bibr" rid="B160">2021</xref>; Varshney et al., <xref ref-type="bibr" rid="B148">2022</xref>). A limitation of selective classification is that it does not take into account the characteristics of the person to whom the prediction is deferred. <italic>Learning to defer</italic> (Madras et al., <xref ref-type="bibr" rid="B99">2018</xref>) is an advancement over selective classification, in which human expertise is being modeled and accounted for in choosing when to abstain. <italic>Learning to complement</italic> (Wilder et al., <xref ref-type="bibr" rid="B158">2021</xref>) further extends this line of research by designing a training strategy that directly optimizes team performance. The next challenging yet crucial step will be to adapt these strategies to handle arbitrary users and general-purpose human-LLM reasoning and decision-making tasks.</p>
<p>A major limitation of current solutions for learning to defer/complement is that they rely on a <italic>separation of responsibilities</italic> between the human and the machine. Banerjee et al. (<xref ref-type="bibr" rid="B8">2024</xref>) argued that this is suboptimal because it leaves humans completely unassisted in the (presumably difficult) cases where the machine defers, while fostering their automation bias when the machine does not defer. The authors proposed an alternative strategy, <italic>learning to guide</italic>, in which the machine is trained to provide helpful hints to assist the user in making the right decision.</p>
<p>Other promising research directions include adapting strategies that have been developed and proven effective in other areas of AI to LLMs. Among these is <italic>conformal prediction</italic> (Angelopoulos and Bates, <xref ref-type="bibr" rid="B5">2023</xref>), which allows a model to return prediction sets that, according to a user-specified probability, are guaranteed to contain the ground truth. This has been empirically shown to improve human decision-making (Straitouri et al., <xref ref-type="bibr" rid="B135">2023</xref>; Cresswell et al., <xref ref-type="bibr" rid="B36">2024</xref>), and it is beginning to be extended to LLM architectures [<italic>conformal language modeling</italic> (Quach et al., <xref ref-type="bibr" rid="B120">2024</xref>)]. Another approach is <italic>mixed-initiative interaction</italic> (Allen et al., <xref ref-type="bibr" rid="B2">1999</xref>; Barnes et al., <xref ref-type="bibr" rid="B11">2015</xref>), where each agent contributes its strengths to the task, with its level of engagement dynamically adjusted to the specific issue at hand. Recent studies have introduced methods for formalizing prompt construction to enable controllable mixed-initiative dialogue generation (Chen et al., <xref ref-type="bibr" rid="B28">2023a</xref>). Finally, <italic>argumentative decision making</italic> (Amgoud and Prade, <xref ref-type="bibr" rid="B3">2009</xref>) applies argumentation theory to enhance team performance by structuring interactions as sequences of arguments and counter-arguments. Recently, argumentative LLMs (Freedman et al., <xref ref-type="bibr" rid="B49">2024</xref>) have been proposed and tested as a method using LLMs to construct formal argumentation frameworks that support reasoning in decision-making.</p>
</sec>
</sec>
<sec sec-type="conclusions" id="s4">
<title>4 Conclusion</title>
<p>A human-centered approach to AI has been increasingly promoted by governmental institutions (European Commission, <xref ref-type="bibr" rid="B45">2020</xref>), with legal requirements in many countries mandating human oversight for high-stakes applications (Government of Canada, <xref ref-type="bibr" rid="B53">2019</xref>; European Commission, <xref ref-type="bibr" rid="B46">2021</xref>). Building on this perspective, we have discussed a range of strategies through which the main limitations of current LLMs could be addressed and proposed two fundamental desiderata&#x02014;mutual understanding and complementary team performance&#x02014;that, in our view, should guide future research on LLMs and beyond. Indeed, while this manuscript focuses on LLMs due to their widespread adoption, including among lay users, many of the points raised may well apply to multimodal and general-purpose foundation models (Sun et al., <xref ref-type="bibr" rid="B137">2024</xref>) when interacting with humans.</p>
<p>The advocated shift in perspective would require greater involvement of cognitive scientists in shaping approaches to overcome LLM limitations and assess their effectiveness, significantly altering priorities regarding problems and goals for the success of LLMs. Future work could explore new evaluation metrics inspired by cognitive science to better measure the effectiveness of these approaches. Indeed, only by combining the knowledge and exploiting the strengths of both humans and LLMs can we have a real chance to achieve a true partnership&#x02014;one that is not only more effective in reducing human-machine biases but also more transparent and fair.</p>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="s5">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec sec-type="author-contributions" id="s6">
<title>Author contributions</title>
<p>AP: Conceptualization, Funding acquisition, Supervision, Writing - original draft, Writing - review &#x00026; editing. AG: Conceptualization, Writing - original draft. BS: Conceptualization, Writing - original draft. PM: Supervision, Writing - review &#x00026; editing, Conceptualization. KT: Conceptualization, Writing - original draft, Writing - review &#x00026; editing, Supervision.</p>
</sec>
<sec sec-type="funding-information" id="s7">
<title>Funding</title>
<p>The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Funded by the European Union, Grant Agreement No. 101120763-TANGO. AP acknowledges the support of the MUR PNRR project FAIR-Future AI Research (PE00000013) funded by the NextGenerationEU. AG was supported by the United Kingdom Research and Innovation (grant EP/S02431X/1), UKRI Centre for Doctoral Training in Biomedical AI at the University of Edinburgh, School of Informatics.</p>
</sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
<p>The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.</p>
</sec>
<sec sec-type="disclaimer" id="s8">
<title>Publisher&#x00027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec sec-type="disclaimer" id="s9">
<title>Author disclaimer</title>
<p>Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Health and Digital Executive Agency (HaDEA). Neither the European Union nor the granting authority can be held responsible for them.</p>
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