AUTHOR=Da Silva Rodrigues Guilherme , Lopes da Silva Leonardo Santos , Crystine da Silva Sobrinho Andressa , Benjamim Jonas , Abud Gabriela Ferreira , Ortiz Gabriela Ueta , Cristini de Freitas Ellen , Bueno Júnior Carlos Roberto 
  
TITLE=Dietary polyphenols and sarcopenia: epigenetic mechanisms and geroscience perspectives for muscle health in aging
  
JOURNAL=Frontiers in Aging
  
VOLUME=Volume 6 - 2025
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2025.1696473
  
DOI=10.3389/fragi.2025.1696473
  
ISSN=2673-6217
  
ABSTRACT=This review explores the effects of dietary polyphenols, such as resveratrol, quercetin, epigallocatechin gallate, and curcumin, on sarcopenia, with a particular focus on the underlying molecular and epigenetic mechanisms. These bioactive compounds may modulate key signaling pathways, including mTOR, NF-κB, and AMPK, while also influencing epigenetic processes such as DNA methylation, histone modifications, and microRNA regulation. Through these actions, polyphenols may reduce oxidative stress and chronic low-grade inflammation (inflammaging), enhance mitochondrial function, and contribute to the preservation of muscle mass and strength in older adults. Evidence from experimental and clinical studies investigating the impact of polyphenols on muscle health and their potential in the prevention or attenuation of sarcopenia will be discussed. In addition, current challenges and future perspectives will be addressed, emphasizing the role of epigenetic biomarkers and the potential synergy with physical exercise as part of integrated geroscience strategies to optimize muscle health during aging.