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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Aging</journal-id>
<journal-title-group>
<journal-title>Frontiers in Aging</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Aging</abbrev-journal-title>
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<issn pub-type="epub">2673-6217</issn>
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<article-id pub-id-type="publisher-id">1594513</article-id>
<article-id pub-id-type="doi">10.3389/fragi.2025.1594513</article-id>
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<subject>Review</subject>
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<title-group>
<article-title>The effectiveness of social support interventions on loneliness among older people in the community: a meta-analysis of randomised controlled trials</article-title>
<alt-title alt-title-type="left-running-head">Huang et al.</alt-title>
<alt-title alt-title-type="right-running-head">
<ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fragi.2025.1594513">10.3389/fragi.2025.1594513</ext-link>
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<contrib contrib-type="author">
<name>
<surname>Huang</surname>
<given-names>Guangting</given-names>
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<sup>1</sup>
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<given-names>Xiaotong</given-names>
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<given-names>Li</given-names>
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<surname>Li</surname>
<given-names>Xiaofang</given-names>
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<surname>Wu</surname>
<given-names>Yuanping</given-names>
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<surname>Zhou</surname>
<given-names>Shiqi</given-names>
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<surname>Wang</surname>
<given-names>Yinhua</given-names>
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<sup>1</sup>
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<xref ref-type="corresp" rid="c001">&#x2a;</xref>
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<aff id="aff1">
<label>1</label>
<institution>The Affiliated Hospital of Guizhou Medical University</institution>, <city>Guiyang</city>, <country country="CN">China</country>
</aff>
<aff id="aff2">
<label>2</label>
<institution>Guizhou Medical University</institution>, <city>Guiyang</city>, <state>Guizhou</state>, <country country="CN">China</country>
</aff>
<aff id="aff3">
<label>3</label>
<institution>Weng&#x2019;an County People&#x2019;s Hospital</institution>, <city>Weng&#x2019;an</city>, <state>Guizhou</state>, <country country="CN">China</country>
</aff>
<author-notes>
<corresp id="c001">
<label>&#x2a;</label>Correspondence: Yinhua Wang, <email xlink:href="mailto:wangyinhua3463@163.com">wangyinhua3463@163.com</email>
</corresp>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-01-07">
<day>07</day>
<month>01</month>
<year>2026</year>
</pub-date>
<pub-date publication-format="electronic" date-type="collection">
<year>2025</year>
</pub-date>
<volume>6</volume>
<elocation-id>1594513</elocation-id>
<history>
<date date-type="received">
<day>16</day>
<month>03</month>
<year>2025</year>
</date>
<date date-type="rev-recd">
<day>20</day>
<month>10</month>
<year>2025</year>
</date>
<date date-type="accepted">
<day>17</day>
<month>12</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2026 Huang, Yang, Yao, Li, Wu, Zhou and Wang.</copyright-statement>
<copyright-year>2026</copyright-year>
<copyright-holder>Huang, Yang, Yao, Li, Wu, Zhou and Wang</copyright-holder>
<license>
<ali:license_ref start_date="2026-01-07">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>To combat loneliness among elderly individuals, it is crucial to identify effective strategies that can alleviate the negative impact of loneliness on their overall well-being.</p>
</sec>
<sec>
<title>Objective</title>
<p>This study evaluated social support programs&#x2019; impact on loneliness in community-dwelling older adults. The goal was to inform tailored interventions that decrease loneliness and improve quality of life.</p>
</sec>
<sec>
<title>Methods</title>
<p>We systematically searched ten electronic databases (EMBASE, PubMed, Cochrane Library, Web of Science, CNKI, Weipu, WanFang, CBM) from inception to December 31, 2023, with citation chasing. Included randomized controlled trials (RCTs) tested social support interventions for loneliness reduction. Two independent reviewers extracted participant details, study characteristics, interventions, and outcomes. The methodological rigor of the included studies was assessed by JBI critical appraisal checklists.</p>
</sec>
<sec>
<title>Results</title>
<p>Nineteen studies met inclusion criteria, with over half from China (n &#x3d; 7) and the United States (n &#x3d; 4). Meta-analysis showed that social support helped alleviate loneliness and the difference was statistically significant [SMD &#x3d; &#x2212;0.60, 95%<italic>CI</italic> (&#x2212;1.00, &#x2212;0.20), <italic>I</italic>
<sup>2</sup> &#x3d; 93%, <italic>P</italic> &#x3d; 0.003, random effect model]. Subgroup analysis showed significantly lower loneliness scores in experimental groups at less than 3&#xa0;months [SMD &#x3d; &#x2212;0.68, 95%<italic>CI</italic> (&#x2212;1.31, &#x2212;0.06), <italic>I</italic>
<sup>2</sup> &#x3d; 93%, <italic>P</italic> &#x3d; 0.03, random effect model]. In addition, multiple-intervention groups also showed significantly lower scores versus controls. The combined result was [SMD &#x3d; &#x2212;1.26, 95%<italic>CI</italic> (&#x2212;2.20, &#x2212;0.32), <italic>I</italic>
<sup>2</sup> &#x3d; 97%, <italic>P</italic> &#x3d; 0.008, random effect model].</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Social support interventions effectively reduce loneliness among community-dwelling older adults. For practical application, community health professionals are encouraged to implement short-term (&#x2264;3&#xa0;months) multicomponent programs that combine emotional, peer, and technological support, delivered through group counseling, tele-support, or structured social activities. Integrating these interventions into routine community nursing services and local age-friendly programs may enhance mental wellbeing and social connectedness among older adults.</p>
</sec>
</abstract>
<kwd-group>
<kwd>social support</kwd>
<kwd>loneliness</kwd>
<kwd>older adults</kwd>
<kwd>community dwelling</kwd>
<kwd>meta-analysis</kwd>
</kwd-group>
<funding-group>
<funding-statement>The author(s) declared that financial support was not received for this work and/or its publication.</funding-statement>
</funding-group>
<counts>
<fig-count count="5"/>
<table-count count="2"/>
<equation-count count="0"/>
<ref-count count="48"/>
<page-count count="11"/>
</counts>
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<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Interventions in Aging</meta-value>
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</front>
<body>
<sec sec-type="intro" id="s1">
<title>Introduction</title>
<p>Loneliness is described as an involuntary social isolation, which is prevalent among older adults and may limit their access and ability to maintain social relationships (<xref ref-type="bibr" rid="B25">Lampinen et al., 2022</xref>; <xref ref-type="bibr" rid="B29">Manzanares et al., 2021</xref>). Several studies have indicated that more than 33% of this population experiences isolation (<xref ref-type="bibr" rid="B13">Gardiner et al., 2020</xref>; <xref ref-type="bibr" rid="B39">Timmermans et al., 2019</xref>). Moreover, the frequency of loneliness rises with age (<xref ref-type="bibr" rid="B6">Chen and Gong, 2022</xref>). This condition significantly impacts physical and mental health, being linked to immune dysfunction, inflammation, cognitive decline, depression, anxiety, hypertension, and even premature mortality (<xref ref-type="bibr" rid="B26">Lapane et al., 2022</xref>; <xref ref-type="bibr" rid="B45">Yu et al., 2021</xref>; <xref ref-type="bibr" rid="B33">Perissinotto et al., 2019</xref>). Hence, identifying effective strategies to reduce loneliness among community-dwelling older adults has become a critical public health priority.</p>
<p>Social isolation refers to an objective lack of social contact, whereas loneliness is a subjective perception of insufficient or unsatisfying social relationships (<xref ref-type="bibr" rid="B10">de Jong-Gierveld et al., 2006</xref>; <xref ref-type="bibr" rid="B34">Petersen et al., 2020</xref>). This distinction is particularly important in the present study, because prior research often combined these two outcomes, leading to inconsistent findings regarding intervention effectiveness. By focusing specifically on loneliness&#x2014;a subjective emotional experience&#x2014;our study provides more precise evidence to guide the design of interventions that target perceived rather than structural deficits in social relationships.</p>
<p>Social support has been identified as a key protective factor against loneliness, encompassing emotional support (expressions of empathy and care), instrumental or practical support (assistance with daily activities), and informational support (advice and guidance) (<xref ref-type="bibr" rid="B22">Kassim and Ahmad Badayai, 2023</xref>). Zhang demonstrated a negative correlation between higher social support levels and loneliness (<xref ref-type="bibr" rid="B46">Zhang and Dong, 2022</xref>). Conversely, inadequate social connectedness increases loneliness risk in older adults (<xref ref-type="bibr" rid="B32">O&#x27;Rourke et al., 2018</xref>). Some research suggests that having a large social network may be beneficial, the quality of relationships within that network, such as feeling understood, valued, and supported, may be more critical in reducing loneliness (<xref ref-type="bibr" rid="B16">Hawkley and Kocherginsky, 2018</xref>). While short-term support interventions show positive effects (<xref ref-type="bibr" rid="B9">Dahlberg et al., 2022</xref>), questions remain regarding which forms and durations of support yield the most sustainable effects. Some researchers have previously systematically reviewed interventions for social isolation, which included objective social isolation and loneliness (<xref ref-type="bibr" rid="B19">Ibarra et al., 2020</xref>; <xref ref-type="bibr" rid="B28">Ma et al., 2020</xref>; <xref ref-type="bibr" rid="B31">Noone et al., 2020</xref>). Such an approach may obscure the specific effectiveness of social support on loneliness itself. Hence, our study addressed important evidence gaps in existing literature by: Isolating social support as a standalone intervention category; including only community-based studies to improve contextual relevance; conducting detailed subgroup analyses on duration and format of interventions. These refinements are crucial for informing targeted, sustainable, and culturally appropriate interventions that can be scaled within community health systems.</p>
<p>To address these gaps, this study aimed to analyze randomized controlled trials and perform a meta-analysis to assess the impact of social support interventions on loneliness in older adults living in the community. Our approach provides a more targeted examination of a single social support intervention type, across culturally diverse settings including China, which has been underrepresented in prior meta-analyses. Moreover, we explore effect moderators such as intervention duration (&#x3c;3&#xa0;months, 3&#x2013;6&#xa0;months, &#x3e;6&#xa0;months) and intervention complexity (single and multicomponent). Developing specific and efficient social support programs can aid in decreasing feelings of isolation and enhancing the overall quality of life for older individuals living in the community.</p>
</sec>
<sec sec-type="methods" id="s2">
<title>Methods</title>
<p>The guidelines outlined in the PRISMA Extension Statement for Reporting of Systematic Reviews that Include Meta-Analyses of Health Care Interventions were adhered to when reporting this meta-analysis (<xref ref-type="bibr" rid="B18">Hutton et al., 2015</xref>). The research has been properly recorded in PROSPERO with the registration code CRD42020226523. An earlier version of the study protocol has been published (<xref ref-type="bibr" rid="B42">Wang et al., 2023</xref>).</p>
<sec id="s2-1">
<title>Search strategy</title>
<p>A comprehensive systematic search was conducted across eight electronic databases from inception to 30 June 2024. The following databases were queried: EMBASE, PubMed, the Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (Weipu), WanFang Database, and China Biology Medicine disc (CBM). Search terms were developed by combining Medical Subject Headings (MeSH) and free-text keywords related to three domains: loneliness (e.g., &#x201c;social isolation&#x201d; or &#x201c;loneliness&#x201d; or &#x201c;social exclusion&#x201d; or &#x201c;social exclusions&#x201d; or &#x201c;ostracism&#x201d; or &#x201c;social alienation&#x201d;), old adults (e.g., &#x201c;aged&#x201d; or &#x201c;elderly&#x201d; or &#x201c;oldest old&#x201d; or &#x201c;agenarians&#x201d; or &#x201c;nonagenarian&#x201d; or &#x201c;octogenarian&#x201d; or &#x201c;centenarian&#x201d; or &#x201c;old people or &#x201c;old person&#x201d; or &#x201c;old adult&#x201d;), and social support interventions (e.g., &#x201c;social support&#x201d; or &#x201c;social care&#x201d; or &#x201c;psychosocial support&#x201d; or &#x201c;psychological support&#x201d;). Citation chasing was performed by manually screening the reference lists of all included articles and relevant reviews to identify additional studies. Only studies published in English and Chinese were included, due to database coverage and the language proficiency of the review team. Grey literature was not included, as this study focused on peer-reviewed evidence.</p>
</sec>
<sec id="s2-2">
<title>Inclusion and exclusion criteria</title>
<p>Inclusion criteria for the studies were as follows: (a) individuals aged 60 years or older residing in the community; (b) the experimental group received social support interventions of any kind; (c) validated tools like the Los Angeles Loneliness Scale from UCLA (UCLA), the De Jong Loneliness Scale (DJLS), the PROMIS-L Social Isolation Scale (PROMIS-L), Ando-Osada-Kodama (AOK) loneliness scale; (d) comparisons were made against passive (usual care) or active (non-social support) control groups; (e) study design was randomized controlled trial (RCT); (f) publications were in English or Chinese. The exclusion criteria were (a) no full text; (b) studies that reported duplicate data.</p>
</sec>
<sec id="s2-3">
<title>Study selection and data extraction</title>
<p>The research selection and data extraction process involved three reviewers. Two reviewers autonomously chose all research papers based on their titles, abstracts, and full texts, following the specified inclusion and exclusion criteria. To address any inconsistencies or disputes that arose during the selection process, a third reviewer was brought in for consultation.</p>
<p>Data were extracted using astandardized form. Included in the data were basic information, participant details (including number, eligibility, age, and gender), intervention/exposure specifics (type, frequency, duration, content, comparison with control group, delivery format, provider information), outcome data (effect size, standard deviations, statistical significance), and instruments used. Data missing for relevant outcomes were obtained from original authors via email.</p>
</sec>
<sec id="s2-4">
<title>Quality assessment of included studies</title>
<p>Two researchers independently evaluated the methodological rigor of the studies included, utilizing the Joanna Briggs Institute (JBI) critical appraisal checklists for randomized controlled trials (RCTs) (<xref ref-type="bibr" rid="B30">Munn et al., 2020</xref>). The checklist for randomized controlled trials includes 13 items that can be answered with &#x201c;yes,&#x201d; &#x201c;no,&#x201d; &#x201c;unclear&#x201d; or &#x201c;not applicable,&#x201d; and a &#x201c;yes&#x201d; response is worth one point. Referring to the JBI manual and previous research, RCTs with scores less than seven points were identified as weak quality studies. Any disagreements among reviewers were settled through consensus or conversation with a third reviewer.</p>
</sec>
<sec id="s2-5">
<title>Statistical analysis</title>
<p>Review Manager (RevMan 5.3) and R Studio softwares were used for quantitative analysis of selected studies. The research utilized a narrative approach that was not suitable for quantitative analysis in the meta-analysis. The inverse variance method was employed in meta-analysis to determine the weights assigned to the studies. Effect size was determined by calculating the mean and standard deviation (SD) of the difference between scores at the last follow-up and baseline. In the pooled analysis, mean differences (MD) or standardized mean differences (SMD) were utilized as effect estimates along with their corresponding 95% confidence intervals (CI). SMD is utilized when assessing the identical result using a distinct tool compared to the identical result assessed using the identical tool. Statistical heterogeneity was assessed using the Chi-squared test and I<sup>2</sup> statistic. A random-effects model was adopted when significant heterogeneity was detected (I<sup>2</sup> &#x3e; 40% or p &#x3c; 0.05); otherwise, a fixed-effects model was used. Sensitivity analyses were conducted by excluding lower-quality studies to examine the robustness of results. Sensitivity tests were performed to evaluate the impact of a low-quality study on combined results. Publication bias was evaluated visually via funnel plots and statistically using Egger&#x2019;s regression test. An analysis of subgroups was conducted to investigate how various lengths and forms of social support impact results.</p>
</sec>
</sec>
<sec sec-type="results" id="s3">
<title>Results</title>
<sec id="s3-1">
<title>Study selection</title>
<p>A total of 2,420 articles were retrieved in <xref ref-type="fig" rid="F1">Figure 1</xref>. Out of the articles reviewed, 789 duplicates were removed using Endnote software, 1,490 articles were eliminated based on title and abstract, leaving 141 articles for full-text screening. This study ultimately incorporated 19 research studies (<xref ref-type="bibr" rid="B1">Banks and Banks, 2005</xref>; <xref ref-type="bibr" rid="B4">Chang et al., 2018</xref>; <xref ref-type="bibr" rid="B7">Choi et al., 2020</xref>; <xref ref-type="bibr" rid="B8">Cohen-Mansfield et al., 2018</xref>; <xref ref-type="bibr" rid="B12">Galinha et al., 2021</xref>; <xref ref-type="bibr" rid="B14">Gilbody et al., 2021</xref>; <xref ref-type="bibr" rid="B15">Gu et al., 2019</xref>; <xref ref-type="bibr" rid="B48">Jos&#x00E9;. et al., 2022</xref>; <xref ref-type="bibr" rid="B20">Ilgaz et al., 2023</xref>; <xref ref-type="bibr" rid="B23">Kremers et al., 2006</xref>; <xref ref-type="bibr" rid="B24">Lai et al., 2020</xref>; <xref ref-type="bibr" rid="B27">Larsson et al., 2016</xref>; <xref ref-type="bibr" rid="B36">Ristolainen et al., 2020</xref>; <xref ref-type="bibr" rid="B37">Rodr&#xed;guez-Romero et al., 2021</xref>; <xref ref-type="bibr" rid="B38">Saito et al., 2012</xref>; <xref ref-type="bibr" rid="B41">Wang et al., 2014</xref>; <xref ref-type="bibr" rid="B43">Wei et al., 2021</xref>; <xref ref-type="bibr" rid="B44">Yang et al., 2023</xref>; <xref ref-type="bibr" rid="B47">Zhou et al., 2014</xref>).</p>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption>
<p>PRISMA flow chart of study selection.</p>
</caption>
<graphic xlink:href="fragi-06-1594513-g001.tif">
<alt-text content-type="machine-generated">Flowchart depicting a systematic review process. Initial records (2,420) include duplicates (789) from various sources like CNKI, PubMed, and others. After deduplication, 1,631 records were screened, excluding 1,490. One hundred forty-one full-text articles were assessed for eligibility. One hundred twenty-two articles were excluded due to reasons like duplicates (7), not randomized controlled trials (51), not involving old patients (16), incomplete data (21), and other outcomes (27). Nineteen studies were included in the network analysis.</alt-text>
</graphic>
</fig>
</sec>
<sec id="s3-2">
<title>Study characteristics</title>
<p>The characteristics of the included studies are displayed in <xref ref-type="table" rid="T1">Table 1</xref>. China (<italic>n</italic> &#x3d; 7) and United States (<italic>n</italic> &#x3d; 4) accounted for the majority of the studies conducted. The 16 studies included 1,809 subjects, with sample sizes varying from 14 to 392 older adults. The average age of the population fell between 60.00 and 84.17 years. The types of interventions were divided into single intervention (<italic>n</italic> &#x3d; 12) and multiple intervention (<italic>n</italic> &#x3d; 7). The single intervention were various, including group counseling (<xref ref-type="bibr" rid="B15">Gu et al., 2019</xref>; <xref ref-type="bibr" rid="B41">Wang et al., 2014</xref>), tele-support (<xref ref-type="bibr" rid="B7">Choi et al., 2020</xref>; <xref ref-type="bibr" rid="B14">Gilbody et al., 2021</xref>), social activity (<xref ref-type="bibr" rid="B12">Galinha et al., 2021</xref>; <xref ref-type="bibr" rid="B27">Larsson et al., 2016</xref>), animal-assisted therapy (<xref ref-type="bibr" rid="B1">Banks and Banks, 2005</xref>), professional support (<xref ref-type="bibr" rid="B47">Zhou et al., 2014</xref>), peer support (<xref ref-type="bibr" rid="B24">Lai et al., 2020</xref>), Group intervention of Technology (<xref ref-type="bibr" rid="B43">Wei et al., 2021</xref>), support from themselves (<xref ref-type="bibr" rid="B23">Kremers et al., 2006</xref>), and I-SOCIAL intervention (<xref ref-type="bibr" rid="B8">Cohen-Mansfield et al., 2018</xref>). The interventions in control group were usual care (<italic>n</italic> &#x3d; 12), follow-up visits (<italic>n</italic> &#x3d; 2), no treatment (<italic>n</italic> &#x3d; 2), and tele-support (<italic>n</italic> &#x3d; 3). The intervention duration ranged from 4&#xa0;weeks to 3&#xa0;years. Half of the studies conducted follow-up after intervention, but other studies did not describe the follow-up period. Follow-up duration varied between 1&#xa0;week and 6&#xa0;months. The level of loneliness was assessed through various scales including UCLA (<italic>n</italic> &#x3d; 12), DJLS (<italic>n</italic> &#x3d; 4), PROMIS-L (<italic>n</italic> &#x3d; 1), AOK loneliness scale (<italic>n</italic> &#x3d; 1), and loneliness scale for the elderly (<italic>n</italic> &#x3d; 1). There are numerous variations of the instruments, with UCLA having five versions and DJLS having two.</p>
<table-wrap id="T1" position="float">
<label>TABLE 1</label>
<caption>
<p>Study and patient characteristics (<italic>n</italic> &#x3d; 19).</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Author (year)</th>
<th align="left">Country</th>
<th align="left">Age(E.G.,/CG)</th>
<th align="center">Gender(M/F)</th>
<th align="left">Sample size</th>
<th align="left">Type of intervention</th>
<th align="left">Type of control</th>
<th align="left">Duration of trial</th>
<th align="left">Follow up</th>
<th align="left">Instruments</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">
<xref ref-type="bibr" rid="B49">Ay&#x15f;eg&#xfc;l and Sebahat (2023)</xref>
</td>
<td align="left">Turkey</td>
<td align="left">&#x2265;65</td>
<td align="center">0/69</td>
<td align="center">69</td>
<td align="left">Group support, person-centred interventions</td>
<td align="left">Usual care</td>
<td align="left">12&#xa0;weeks</td>
<td align="left">NA</td>
<td align="left">Loneliness scale for the elderly</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B1">Banks and Banks (2005)</xref>
</td>
<td align="left">United States</td>
<td align="left">83.2 &#xb1; 5.4/81.1 &#xb1; 4.5</td>
<td align="center">14/19</td>
<td align="center">33</td>
<td align="left">Animal-assisted therapy</td>
<td align="left">Active control</td>
<td align="left">6&#xa0;weeks</td>
<td align="left">NA</td>
<td align="left">UCLA scale 20 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B4">Chang et al. (2018)</xref>
</td>
<td align="left">China</td>
<td align="left">80.56 &#xb1; 4.98/80.47 &#xb1; 4.53</td>
<td align="center">44/55</td>
<td align="center">99</td>
<td align="left">Theory-based multi-level interventions</td>
<td align="left">Usual care</td>
<td align="left">6&#xa0;months</td>
<td align="left">NA</td>
<td align="left">UCLA scale 20 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B7">Choi et al. (2020)</xref>
</td>
<td align="left">United States</td>
<td align="left">74.4 &#xb1; 8.2/73.5 &#xb1; 9.8</td>
<td align="center">34/55</td>
<td align="center">89</td>
<td align="left">Tele-support</td>
<td align="left">Tele- support (friendly visits and active control by phone)</td>
<td align="left">5&#xa0;weeks</td>
<td align="left">6&#x2013;12&#xa0;weeks</td>
<td align="left">Patient-reported outcomes measurement information system) social isolation scale (PROMIS-L)</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B8">Cohen-Mansfield et al. (2018)</xref>
</td>
<td align="left">United States</td>
<td align="left">76.6 &#xb1; 6.8/79 &#xb1; 6.62</td>
<td align="center">14/60</td>
<td align="center">74</td>
<td align="left">I-SOCIAL intervention</td>
<td align="left">Usual care</td>
<td align="left">3&#xa0;years</td>
<td align="left">3&#xa0;months</td>
<td align="left">UCLA scale 8 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B27">Larsson et al. (2016)</xref>
</td>
<td align="left">Sweden</td>
<td align="left">&#x3e;60</td>
<td align="center">6/24</td>
<td align="center">30</td>
<td align="left">Social activity</td>
<td align="left">Usual care</td>
<td align="left">3&#xa0;months</td>
<td align="left">3&#xa0;months</td>
<td align="left">UCLA scale 20 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B12">Galinha et al. (2021)</xref>
</td>
<td align="left">United States</td>
<td align="left">76.76 &#xb1; 8.93/76.51 &#xb1; 8.66</td>
<td align="center">25/124</td>
<td align="center">149</td>
<td align="left">Social activity</td>
<td align="left">Usual care</td>
<td align="left">4&#xa0;months</td>
<td align="left">NA</td>
<td align="left">UCLA scale 4 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B14">Gilbody et al. (2021)</xref>
</td>
<td align="left">North East of England</td>
<td align="left">74.2 &#xb1; 5.4/74.1 &#xb1; 5.6</td>
<td align="center">37/59</td>
<td align="center">96</td>
<td align="left">Tele support</td>
<td align="left">Usual care</td>
<td align="left">4&#x2013;6&#xa0;weeks</td>
<td align="left">1&#x2013;3&#xa0;months</td>
<td align="left">De Jong loneliness scale 11-item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B15">Gu et al. (2019)</xref>
</td>
<td align="left">China</td>
<td align="left">83.42 &#xb1; 4.48/84.17 &#xb1; 5.22</td>
<td align="center">21/23</td>
<td align="center">44</td>
<td align="left">Group counseling</td>
<td align="left">Usual care</td>
<td align="left">4&#xa0;weeks</td>
<td align="left">NA</td>
<td align="left">UCLA scale 20 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B48">Jos&#xe9; et al. (2022)</xref>
</td>
<td align="left">Spain</td>
<td align="left">80.79 &#xb1; 5.38/82.91 &#xb1; 6.86</td>
<td align="center">28/91</td>
<td align="center">119</td>
<td align="left">Multicomponent support</td>
<td align="left">Usual care</td>
<td align="left">16&#xa0;weeks</td>
<td align="left">6&#xa0;months</td>
<td align="left">De Jong loneliness scale 6-item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B23">Kremers et al. (2006)</xref>
</td>
<td align="left">Netherlands</td>
<td align="left">62.8 &#xb1; 6.4/65.2 &#xb1; 7.6</td>
<td align="center">0/119</td>
<td align="center">119</td>
<td align="left">Support from themselves</td>
<td align="left">No treatment</td>
<td align="left">6&#xa0;weeks</td>
<td align="left">6&#xa0;months</td>
<td align="left">De Jong loneliness scale 11-item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B24">Lai et al. (2020)</xref>
</td>
<td align="left">China</td>
<td align="left">&#x3e;60</td>
<td align="center">22/38</td>
<td align="center">60</td>
<td align="left">Peer support</td>
<td align="left">Tele- support (Phone)</td>
<td align="left">8&#xa0;weeks</td>
<td align="left">1&#x2013;10&#xa0;weeks</td>
<td align="left">De Jong loneliness scale 6-item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B36">Ristolainen et al. (2020)</xref>
</td>
<td align="left">Finland</td>
<td align="left">76.8 &#xb1; 7.2/76.8 &#xb1; 7.76</td>
<td align="center">67/325</td>
<td align="center">392</td>
<td align="left">Social support,<break/>Counseling, and activities</td>
<td align="left">Usual care</td>
<td align="left">6&#xa0;months</td>
<td align="left">3&#x2013;6&#xa0;months</td>
<td align="left">UCLA scale 12-item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B37">Rodr&#xed;guez-Romero et al. (2021)</xref>
</td>
<td align="left">Barcelona</td>
<td align="left">80.5 &#xb1; 6.6/79.8 &#xb1; 17.4</td>
<td align="center">29/26</td>
<td align="center">55</td>
<td align="left">Community and professional support</td>
<td align="left">Usual care</td>
<td align="left">6&#xa0;months</td>
<td align="left">NA</td>
<td align="left">UCLA scale</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B38">Saito et al. (2012)</xref>
</td>
<td align="left">Japan</td>
<td align="left">72.6 &#xb1; 4.4/72.8 &#xb1; 4.8</td>
<td align="center">20/40</td>
<td align="center">60</td>
<td align="left">A group-based educational, cognitive, and social support program</td>
<td align="left">Usual care</td>
<td align="left">1&#xa0;month</td>
<td align="left">1&#x2013;6&#xa0;months</td>
<td align="left">Ando-Osada-Kodama (AOK) loneliness scale</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B41">Wang et al. (2014)</xref>
</td>
<td align="left">China</td>
<td align="left">&#x3e;60</td>
<td align="center">NA</td>
<td align="center">30</td>
<td align="left">Group counseling</td>
<td align="left">Usual care</td>
<td align="left">4&#xa0;weeks</td>
<td align="left">NA</td>
<td align="left">UCLA scale 20 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B43">Wei et al. (2021)</xref>
</td>
<td align="left">China</td>
<td align="left">&#x3e;60</td>
<td align="center">NA</td>
<td align="center">14</td>
<td align="left">Group intervention of technology</td>
<td align="left">No treatment</td>
<td align="left">5&#xa0;weeks</td>
<td align="left">NA</td>
<td align="left">ULS scale 6 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B44">Yang et al. (2023)</xref>
</td>
<td align="left">China</td>
<td align="left">68.07 &#xb1; 6.68/69.00 &#xb1; 6.04</td>
<td align="center">32/57</td>
<td align="center">89</td>
<td align="left">Tele-support and peer support</td>
<td align="left">Tele-support (line group)</td>
<td align="left">8&#xa0;weeks</td>
<td align="left">NA</td>
<td align="left">UCLA scale 20 item</td>
</tr>
<tr>
<td align="left">
<xref ref-type="bibr" rid="B47">Zhou et al. (2014)</xref>
</td>
<td align="left">China</td>
<td align="left">&#x3e;60</td>
<td align="center">94/114</td>
<td align="center">208</td>
<td align="left">Professional support</td>
<td align="left">Follow-up visits</td>
<td align="left">1&#xa0;year</td>
<td align="left">NA</td>
<td align="left">UCLA scale 20 item</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>NR: Not Reported.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s3-3">
<title>Methodological quality and risk of bias within studies</title>
<p>The summary of the bias risk in the 19 studies was provided in supplementary material. 17 RCTs met 7&#x2013;13 items. No randomized controlled trials achieved complete blinding of participants, providers, and evaluators at the same time. Five randomized controlled trials failed to meet the five criteria of the JBI critical appraisal checklist. Twelve randomized controlled trials did not clearly report allocation concealment, did not conduct intention-to-treat analysis, and did not blind participants, implementers, and outcome assessors.</p>
</sec>
<sec id="s3-4">
<title>Effect of social support on reducing loneliness</title>
<p>A meta-analysis was performed on 19 studies in <xref ref-type="fig" rid="F2">Figure 2</xref> to investigate how social support can reduce loneliness. The analysis included 1809 participants, with 892 in the experimental group and 917 in the control group. The primary analysis showed a significant impact of the intervention compared to the control group in decreasing feelings of isolation [SMD &#x3d; &#x2212;0.60, 95%<italic>CI</italic> (&#x2212;1.00, &#x2212;0.20), <italic>P</italic> &#x3d; 0.003, random effect model], suggesting a substantial effect with a wide yet meaningful confidence range. The studies showed a significant amount of diversity (<italic>I</italic>
<sup>2</sup> &#x3d; 93%, <italic>P</italic> &#x3c; 0.001), suggesting a substantial level of variation among them. Therefore, further subgroup analysis was conducted to examine potential factors explaining the heterogeneity among these studies.</p>
<fig id="F2" position="float">
<label>FIGURE 2</label>
<caption>
<p>Effect of social support on loneliness in older adults.</p>
</caption>
<graphic xlink:href="fragi-06-1594513-g002.tif">
<alt-text content-type="machine-generated">Forest plot showing a meta-analysis of 19 studies comparing experimental and control groups. The x-axis represents the standardized mean difference (SMD) with a confidence interval. Most studies favor the experimental group. The overall effect shows a statistically significant result with an SMD of -0.60 and a p-value of 0.003, indicating a higher effect in the experimental group.</alt-text>
</graphic>
</fig>
<p>Given the potential impact of intervention duration on effectiveness, this study categorized duration into three subgroups. The findings indicated that participants in the experimental group experienced notably reduced feelings of lonely in comparison to those in the control group within less than 3 months. The combined results were [SMD &#x3d; &#x2212;0.68, 95%<italic>CI</italic> (&#x2212;1.31, &#x2212;0.06), <italic>I</italic>
<sup>2</sup> &#x3d; 93%, <italic>P</italic> &#x3d; 0.03, random effect model]. No significant variances were noted between the intervention and control groups when the intervention lasted 3&#x2013;6 months or more than 6 months [SMD &#x3d; &#x2212;0.66, 95%<italic>CI</italic> (&#x2212;1.50, 0.18), <italic>I</italic>
<sup>2</sup> &#x3d; 96%, <italic>P</italic> &#x3d; 0.13, random effect model] and [SMD &#x3d; &#x2212;0.17, 95%<italic>CI</italic> (&#x2212;0.41, 0.06), <italic>I</italic>
<sup>2</sup> &#x3d; 0%, <italic>P</italic> &#x3d; 0.52, random effect model] in <xref ref-type="fig" rid="F3">Figure 3</xref>.</p>
<fig id="F3" position="float">
<label>FIGURE 3</label>
<caption>
<p>Subgroup analysis of different duration of social support on loneliness in older adults.</p>
</caption>
<graphic xlink:href="fragi-06-1594513-g003.tif">
<alt-text content-type="machine-generated">Forest plot showing the standardized mean differences for three subgroups: less than three months, three to six months, and more than six months, comparing experimental and control groups. Each study within the subgroups is listed with mean, standard deviation, and total sample size. The summary effects for each subgroup and overall are shown with diamonds, representing a combined effect size. Confidence intervals are provided for individual studies and overall effects, with heterogeneity statistics included. The scale at the bottom indicates favoring of experimental or control groups. Total heterogeneity is 93%, with a significant overall effect favoring the experimental group.</alt-text>
</graphic>
</fig>
<p>It stratified interventions into two subgroups based on the potential impact of intervention types on efficacy, including single intervention and multiple intervention. The findings indicated that the multiple intervention group had notably reduced feelings of loneliness in comparison to the control group. The pooled results were [SMD &#x3d; &#x2212;1.26, 95%<italic>CI</italic> (&#x2212;2.20, &#x2212;0.32), <italic>I</italic>
<sup>2</sup> &#x3d; 97%, <italic>P</italic> &#x3c; 0.001, random effect model]. In contrast, the subset that received single treatment did not display a notable distinction between the groups that received intervention and those that did not [SMD &#x3d; &#x2212;0.22, 95%CI (&#x2212;0.55, 0.12), I<sup>2</sup> &#x3d; 82%, P &#x3d; 0.200, random effect model] in <xref ref-type="fig" rid="F4">Figure 4</xref>.</p>
<fig id="F4" position="float">
<label>FIGURE 4</label>
<caption>
<p>Subgroup analysis of different types of social support on loneliness in older adults.</p>
</caption>
<graphic xlink:href="fragi-06-1594513-g004.tif">
<alt-text content-type="machine-generated">Forest plot showing the results of a meta-analysis comparing experimental and control groups across various studies. The plot includes studies with both single and multiple interventions. Each study&#x27;s mean, standard deviation, and total sample size are listed along with the standardized mean difference and 95% confidence interval. Subtotals for single and multiple interventions, as well as the total, are presented, with diamonds representing combined effect sizes. The plot displays heterogeneity and overall effect tests, favoring the experimental group in most cases.</alt-text>
</graphic>
</fig>
</sec>
<sec id="s3-5">
<title>Publication bias analysis</title>
<p>According to the funnel plot analysis and the Egger test conducted using R Studio on 19 included papers in this study (t &#x3d; &#x2212;1.43, df &#x3d; 17, p &#x3d; 0.171), suggesting low probability of publication bias in <xref ref-type="table" rid="T2">Table 2</xref> and <xref ref-type="fig" rid="F5">Figure 5</xref>.</p>
<table-wrap id="T2" position="float">
<label>TABLE 2</label>
<caption>
<p>Reporting quality assessment of 19 publications (JBI critical appraisal checklist for randomized controlled trials).</p>
</caption>
<table>
<thead valign="top">
<tr>
<th rowspan="2" align="center">Author, year/items</th>
<th colspan="2" align="center">Q1</th>
<th colspan="2" align="center">Q2</th>
<th colspan="2" align="center">Q3</th>
<th colspan="2" align="center">Q4</th>
<th colspan="2" align="center">Q5</th>
<th colspan="2" align="center">Q6</th>
<th colspan="2" align="center">Q7</th>
<th colspan="2" align="center">Q8</th>
<th colspan="2" align="center">Q9</th>
<th colspan="2" align="center">Q10</th>
<th colspan="2" align="center">Q11</th>
<th colspan="2" align="center">Q12</th>
<th colspan="2" align="center">Q13</th>
</tr>
<tr>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
<th align="center">R1</th>
<th align="center">R2</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="center">
<xref ref-type="bibr" rid="B49">Ay&#x15f;eg&#xfc;l, 2023</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B1">Banks and Banks (2005)</xref>
</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B4">Chang et al. (2018)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B7">Choi et al. (2020)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B8">Cohen-Mansfield et al. (2018)</xref>
</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B27">Larsson et al. (2016)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B12">Galinha et al. (2021)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B14">Gilbody et al. (2021)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B15">Gu et al. (2019)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B48">Jos&#xe9;, 2022</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B23">Kremers et al. (2006)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B24">Lai et al. (2020)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B36">Ristolainen et al. (2020)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B37">Rodr&#xed;guez-Romero et al. (2021)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B38">Saito et al. (2012)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B41">Wang et al. (2014)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B43">Wei et al. (2021)</xref>
</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B44">Yang et al. (2023)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
<tr>
<td align="center">
<xref ref-type="bibr" rid="B47">Zhou et al. (2014)</xref>
</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">N</td>
<td align="center">UN</td>
<td align="center">UN</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
<td align="center">Y</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>N, No; Y, Yes; UN, Unclear; R1, Rater &#x23;1; R2, Rater &#x23;2. Q1, Was a truly randomised grouping of study participants used? Q2, Was allocation to treatment groups concealed? Q3, Were treatment groups similar at the baseline? Q4, Were participants blind to treatment assignment? Q5, Were those delivering treatment blind to treatment assignment? Q6, Were outcomes assessors blind to treatment assignment? Q7, Were treatment groups treated identically other than the intervention of interest? Q8, Was follow up complete and if not, were differences between groups in terms of their follow up adequately described and analyzed? Q9, Were participants analyzed in the groups to which they were randomized? Q10, Were outcomes measured in the same way for treatment groups? Q11, Were outcomes measured in a reliable way? Q12, Was appropriate statistical analysis used? Q13, Was the trial design appropriate, and any deviations from the standard RCT, design (individual randomization, parallel groups) accounted for in the conduct and analysis of the trial?</p>
</fn>
</table-wrap-foot>
</table-wrap>
<fig id="F5" position="float">
<label>FIGURE 5</label>
<caption>
<p>Funnel plot and Egger test results.</p>
</caption>
<graphic xlink:href="fragi-06-1594513-g005.tif">
<alt-text content-type="machine-generated">Funnel plot displaying Standard Error (SE) against Standard Mean Difference (SMD) with circles representing data points. A vertical dashed line is centered. The accompanying text outlines a regression test for funnel plot asymmetry with a model using weighted regression and standard error as a predictor. Test results include t-statistic, degrees of freedom, p-value, and limit estimate with confidence interval.</alt-text>
</graphic>
</fig>
</sec>
</sec>
<sec sec-type="discussion" id="s4">
<title>Discussion</title>
<p>This meta-analysis provides the first comprehensive evaluation of interventions aimed at providing social support to address loneliness among older individuals. In this study, we meta-analyzed data from 19 peer-reviewed articles and involved 1809 participants. We found a significant result about social support on loneliness, which was differ from some studies. According to Ma, R. M., systematic evaluations of interventions on loneliness and social isolation did not show clear effects (<xref ref-type="bibr" rid="B28">Ma et al., 2020</xref>). The notable finding in this research could be associated with the particular strategy known as social support. This study verified that social support can be considered a useful healthcare service to reduce loneliness in elderly.</p>
<p>Social support encompasses various forms of aid such as tangible help, emotional support, close relationships, guidance, input, and beneficial social connections within different areas of support (<xref ref-type="bibr" rid="B42">Wang et al., 2023</xref>). According to the different sources of social support, which includes community support, volunteer support, family support, professional support, and peer support (<xref ref-type="bibr" rid="B5">Chen et al., 2014</xref>; <xref ref-type="bibr" rid="B46">Zhang and Dong, 2022</xref>). There is difficulty in conducting a subgroup analysis of social support based on the intervention classification in the included studies. Hence, we divided the types of interventions into single intervention and multiple intervention. The results indicate that multiple interventions are more effective than single interventions. It is recommended that researchers should develop rigorous intervention program based on the classification of social support, to provide clear guidance for clinical nursing staff.</p>
<p>Group counseling, tele-support and social activity were the popular types of social support. Providing individuals with a shared space where they can express their feelings of loneliness and be understood by others experiencing similar emotions and professional development is proven to be beneficial in group counseling (<xref ref-type="bibr" rid="B15">Gu et al., 2019</xref>). Tele-support plays several roles in addressing loneliness and provides a convenient platform for individuals to establish and maintain social connections remotely. It can provide remote mental health support, educational programs, crisis intervention for old people (<xref ref-type="bibr" rid="B2">Bar-Tur et al., 2022</xref>; <xref ref-type="bibr" rid="B7">Choi et al., 2020</xref>). Additionally, it demonstrated that engaging in social activities fosters emotional support by fostering a sense of belonging to a group. The identification with a group is essential for older adults to experience wellbeing and health advantages (<xref ref-type="bibr" rid="B12">Galinha et al., 2021</xref>). Tele-support and social activities constitute essential components of standard community care for older adults, given their demonstrable efficacy and broad applicability.</p>
<p>According to Dahlberg&#x2019;s research identified that interventions focusing on social connectedness had short-term but not sustained effects on loneliness (<xref ref-type="bibr" rid="B9">Dahlberg et al., 2022</xref>), our subgroup analysis highlighted short-term (&#x3c;3 months) interventions as optimal for effectiveness and feasibility. Balancing a sustainability threshold (&#x3c;6 months) that mitigates attrition risks (<xref ref-type="bibr" rid="B40">Tkatch et al., 2021</xref>; <xref ref-type="bibr" rid="B3">Bruce et al., 2021</xref>). Prolonged interventions demonstrate diminishing returns due to participant fatigue (<xref ref-type="bibr" rid="B11">Fakoya et al., 2020</xref>), reduced relevance from evolving health/social circumstances (<xref ref-type="bibr" rid="B21">Jin et al., 2021</xref>), and resource inefficiency (<xref ref-type="bibr" rid="B35">Quan et al., 2020</xref>). This equilibrium period maximizes intervention efficacy while preventing the diminished benefits observed in longer trials.</p>
<sec id="s4-1">
<title>Strengths and limitations</title>
<p>There are multiple advantages to this research. This study explored the effects of different social support on elderly loneliness. Analyzing various durations and types of interventions further assessed the impact of social support on loneliness in elderly individuals. Additionally, the present research has its own constraints. Due to inconsistent classification of social support in the included studies is confused, it is not possible to analyze subgroup based on a certain classification and determine which specific type of social support is more effective for elderly loneliness. Although the included studies provided valuable insight, some contextual factors such as gender, socioeconomic status, and rural&#x2013;urban differences were rarely reported or inconsistently measured, precluding subgroup analysis. The instruments of outcomes included in the study were validated tools, there were too many versions available. It may contribute to statistical heterogeneity. Despite efforts to reach out to the authors, numerous studies were excluded during the literature screening process due to insufficient data. This may lead to a potential bias about our results. Variations in national healthcare systems and community care structures may influence the implementation and sustainability of social support interventions. Additionanlly, differences in intervention providers can lead to inconsistencies in quality and intensity, contributing to heterogeneity. Future research should further examine how these factors affect intervention outcomes.</p>
</sec>
</sec>
</body>
<back>
<sec sec-type="author-contributions" id="s5">
<title>Author contributions</title>
<p>GH: Data curation, Methodology, Supervision, Validation, Writing &#x2013; review and editing. XY: Supervision, Investigation, Formal Analysis, Writing &#x2013; original draft, Project administration. LY: Methodology, Formal Analysis, Data curation, Software, Writing &#x2013; review and editing, Conceptualization, Investigation, Supervision, Writing &#x2013; original draft, Project administration. XL: Investigation, Methodology, Supervision, Writing &#x2013; original draft, Formal Analysis. YuW: Software, Data curation, Writing &#x2013; original draft, Methodology. SZ: Data curation, Formal analysis, Writing &#x2013; review and editing. YiW: Data curation, Software, Investigation, Writing &#x2013; review and editing, Conceptualization, Project administration, Writing &#x2013; original draft, Methodology, Formal Analysis, Supervision.</p>
</sec>
<ack>
<title>Acknowledgements</title>
<p>We would like to thank all authors of studies included in this meta-analysis.</p>
</ack>
<sec sec-type="COI-statement" id="s7">
<title>Conflict of interest</title>
<p>The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="ai-statement" id="s8">
<title>Generative AI statement</title>
<p>The author(s) declared that generative AI was not used in the creation of this manuscript.</p>
<p>Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.</p>
</sec>
<sec sec-type="disclaimer" id="s9">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec sec-type="supplementary-material" id="s10">
<title>Supplementary material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fragi.2025.1594513/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/fragi.2025.1594513/full&#x23;supplementary-material</ext-link>
</p>
<supplementary-material xlink:href="Table1.docx" id="SM1" mimetype="application/docx" xmlns:xlink="http://www.w3.org/1999/xlink"/>
<supplementary-material xlink:href="Image1.tif" id="SM2" mimetype="application/tif" xmlns:xlink="http://www.w3.org/1999/xlink"/>
</sec>
<fn-group>
<fn fn-type="custom" custom-type="edited-by">
<p>
<bold>Edited by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/804230/overview">Anubhuti Dubey</ext-link>, Deen Dayal Upadhyay Gorakhpur University, India</p>
</fn>
<fn fn-type="custom" custom-type="reviewed-by">
<p>
<bold>Reviewed by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2945762/overview">Selma Durmu&#x15f; Sarikahya</ext-link>, Artvin Coruh University, T&#xfc;rkiye</p>
<p>
<ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3144733/overview">Ramachandran Ramkumar</ext-link>, College of Food and Dairy Technology Koduvalli, India</p>
</fn>
</fn-group>
<ref-list>
<title>References</title>
<ref id="B49">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ay&#x015F;eg&#x00FC;l</surname>
<given-names>I.</given-names>
</name>
<name>
<surname>Sebahat</surname>
<given-names>G.</given-names>
</name>
</person-group> (<year>2023</year>). <article-title>Effectiveness of INOSEL program consisting of Integrative Nursing and Omaha System for older women feeling loneliness: a randomised controlled trial</article-title>. <source>Aging Clin. Exp. Res.</source> <volume>35</volume> (<issue>11</issue>), <fpage>2769</fpage>&#x2013;<lpage>2781</lpage>. <pub-id pub-id-type="doi">10.1007/s40520-023-02559-9</pub-id>
<pub-id pub-id-type="pmid">37759148</pub-id>
</mixed-citation>
</ref>
<ref id="B1">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Banks</surname>
<given-names>M. R.</given-names>
</name>
<name>
<surname>Banks</surname>
<given-names>W. A.</given-names>
</name>
</person-group> (<year>2005</year>). <article-title>The effects of group and individual animal-assisted therapy on loneliness in residents of long-term care facilities</article-title>. <source>Anthrozoos</source> <volume>18</volume> (<issue>4</issue>), <fpage>396</fpage>&#x2013;<lpage>408</lpage>. <pub-id pub-id-type="doi">10.2752/089279305785593983</pub-id>
</mixed-citation>
</ref>
<ref id="B2">
<mixed-citation publication-type="book">
<person-group person-group-type="author">
<name>
<surname>Bar-Tur</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Inbal-Jacobson</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Brik-Deshen</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Zilbershlag</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Naim</surname>
<given-names>S. P.</given-names>
</name>
<name>
<surname>Brick</surname>
<given-names>Y.</given-names>
</name>
</person-group> (<year>2022</year>). &#x201c;<article-title>Telephone-based emotional support for older adults during the COVID-19 pandemic</article-title>,&#x201d; in <source>The COVID-19 pandemic and older adults</source> (<publisher-name>London, United Kingdom: Routledge</publisher-name>), <fpage>230</fpage>&#x2013;<lpage>246</lpage>.</mixed-citation>
</ref>
<ref id="B3">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bruce</surname>
<given-names>M. L.</given-names>
</name>
<name>
<surname>Pepin</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Marti</surname>
<given-names>C. N.</given-names>
</name>
<name>
<surname>Stevens</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Choi</surname>
<given-names>N. G.</given-names>
</name>
</person-group> (<year>2021</year>). <article-title>One year impact on social connectedness for homebound older adults: randomized controlled trial of tele-delivered behavioral activation Versus tele-delivered friendly visits</article-title>. <source>Am. Journal Geriatric Psychiatry</source> <volume>29</volume> (<issue>8</issue>), <fpage>771</fpage>&#x2013;<lpage>776</lpage>. <pub-id pub-id-type="doi">10.1016/j.jagp.2021.05.005</pub-id>
<pub-id pub-id-type="pmid">34130906</pub-id>
</mixed-citation>
</ref>
<ref id="B4">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chang</surname>
<given-names>W.</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Chen</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>An</surname>
<given-names>S.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Effect of intervention based on health ecology theory on physical and mental health of disabled empty-nest elderly</article-title>. <source>J. Nurs. Sci.</source> <volume>33</volume> (<issue>14</issue>), <fpage>89</fpage>&#x2013;<lpage>92</lpage>. <pub-id pub-id-type="doi">10.3870/j.issn.1001-4152.2018.14.089</pub-id>
</mixed-citation>
</ref>
<ref id="B5">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chen</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Hicks</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>While</surname>
<given-names>A. E. J. H.</given-names>
</name>
<name>
<surname>community</surname>
<given-names>s. c. i. t.</given-names>
</name>
</person-group> (<year>2014</year>). <article-title>Loneliness and social support of older people in C hina: a systematic literature review</article-title>. <source>Health Soc. Care Community</source> <volume>22</volume> (<issue>2</issue>), <fpage>113</fpage>&#x2013;<lpage>123</lpage>. <pub-id pub-id-type="doi">10.1111/hsc.12051</pub-id>
<pub-id pub-id-type="pmid">23714357</pub-id>
</mixed-citation>
</ref>
<ref id="B6">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chen</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Gong</surname>
<given-names>L. J. H.</given-names>
</name>
</person-group> (<year>2022</year>). <article-title>Loneliness in urbanising China</article-title>. <source>Health Soc. Care Community</source> <volume>30</volume> (<issue>3</issue>), <fpage>e812</fpage>&#x2013;<lpage>e822</lpage>. <pub-id pub-id-type="doi">10.1111/hsc.13451</pub-id>
<pub-id pub-id-type="pmid">34096105</pub-id>
</mixed-citation>
</ref>
<ref id="B7">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Choi</surname>
<given-names>N. G.</given-names>
</name>
<name>
<surname>Pepin</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Marti</surname>
<given-names>C. N.</given-names>
</name>
<name>
<surname>Stevens</surname>
<given-names>C. J.</given-names>
</name>
<name>
<surname>Bruce</surname>
<given-names>M. L.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Improving Social Connectedness for Homebound Older Adults: randomized Controlled Trial of Tele-Delivered Behavioral Activation Versus Tele-Delivered Friendly Visits</article-title>. <source>Am. Journal Geriatric Psychiatry</source> <volume>28</volume> (<issue>7</issue>), <fpage>698</fpage>&#x2013;<lpage>708</lpage>. <pub-id pub-id-type="doi">10.1016/j.jagp.2020.02.008</pub-id>
<pub-id pub-id-type="pmid">32238297</pub-id>
</mixed-citation>
</ref>
<ref id="B8">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Cohen-Mansfield</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Hazan</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Lerman</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Shalom</surname>
<given-names>V.</given-names>
</name>
<name>
<surname>Birkenfeld</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Cohen</surname>
<given-names>R.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Efficacy of the I-SOCIAL intervention for loneliness in old age: lessons from a randomized controlled trial</article-title>. <source>J. Psychiatric Research</source> <volume>99</volume>, <fpage>69</fpage>&#x2013;<lpage>75</lpage>. <pub-id pub-id-type="doi">10.1016/j.jpsychires.2018.01.014</pub-id>
<pub-id pub-id-type="pmid">29407289</pub-id>
</mixed-citation>
</ref>
<ref id="B9">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Dahlberg</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>McKee</surname>
<given-names>K. J.</given-names>
</name>
<name>
<surname>Frank</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Naseer</surname>
<given-names>M. J. A.</given-names>
</name>
<name>
<surname>health</surname>
<given-names>m.</given-names>
</name>
</person-group> (<year>2022</year>). <article-title>A systematic review of longitudinal risk factors for loneliness in older adults</article-title>. <source>Aging Ment. Health</source> <volume>26</volume> (<issue>2</issue>), <fpage>225</fpage>&#x2013;<lpage>249</lpage>. <pub-id pub-id-type="doi">10.1080/13607863.2021.1876638</pub-id>
<pub-id pub-id-type="pmid">33563024</pub-id>
</mixed-citation>
</ref>
<ref id="B10">
<mixed-citation publication-type="book">
<person-group person-group-type="author">
<name>
<surname>de Jong-Gierveld</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>van Tilburg</surname>
<given-names>T. G.</given-names>
</name>
<name>
<surname>Dykstra</surname>
<given-names>P. A.</given-names>
</name>
</person-group> (<year>2006</year>). &#x201c;<article-title>Loneliness and social isolation</article-title>,&#x201d; in <source>The Cambridge handbook of personal relationships</source> (<publisher-name>Cambridge University Press</publisher-name>), <fpage>485</fpage>&#x2013;<lpage>500</lpage>.</mixed-citation>
</ref>
<ref id="B11">
<mixed-citation publication-type="book">
<person-group person-group-type="author">
<name>
<surname>Fakoya</surname>
<given-names>O. A.</given-names>
</name>
<name>
<surname>McCorry</surname>
<given-names>N. K.</given-names>
</name>
<name>
<surname>Donnelly</surname>
<given-names>M. J. B. p. h.</given-names>
</name>
</person-group> (<year>2020</year>). <source>Loneliness and social isolation interventions for older adults: a scoping review of reviews</source>, <volume>20</volume>, <fpage>1</fpage>&#x2013;<lpage>14</lpage>.<pub-id pub-id-type="pmid">32054474</pub-id>
</mixed-citation>
</ref>
<ref id="B12">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Galinha</surname>
<given-names>I. C.</given-names>
</name>
<name>
<surname>Garc&#xed;a-Mart&#xed;n</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Lima</surname>
<given-names>M. L.</given-names>
</name>
</person-group> (<year>2021</year>). <article-title>Sing4Health: randomised controlled trial of the effects of a singing group program on the subjective and social well-being of older adults</article-title>. <source>Appl. Psychol. Health Well Being</source> <volume>14</volume>, <fpage>176</fpage>&#x2013;<lpage>195</lpage>. <pub-id pub-id-type="doi">10.1111/aphw.12297</pub-id>
<pub-id pub-id-type="pmid">34378330</pub-id>
</mixed-citation>
</ref>
<ref id="B13">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gardiner</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Laud</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Heaton</surname>
<given-names>T.</given-names>
</name>
<name>
<surname>Gott</surname>
<given-names>M.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>What is the prevalence of loneliness amongst older people living in residential and nursing care homes? A systematic review and meta-analysis</article-title>. <source>Age Ageing</source> <volume>49</volume> (<issue>5</issue>), <fpage>748</fpage>&#x2013;<lpage>757</lpage>. <pub-id pub-id-type="doi">10.1093/ageing/afaa049</pub-id>
<pub-id pub-id-type="pmid">32396600</pub-id>
</mixed-citation>
</ref>
<ref id="B14">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gilbody</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Littlewood</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>McMillan</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Chew-Graham</surname>
<given-names>C. A.</given-names>
</name>
<name>
<surname>Bailey</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Gascoyne</surname>
<given-names>S.</given-names>
</name>
<etal/>
</person-group> (<year>2021</year>). <article-title>Behavioural activation to prevent depression and loneliness among socially isolated older people with long-term conditions: the BASIL COVID-19 pilot randomised controlled trial</article-title>. <source>PLoS Medicine</source> <volume>18</volume> (<issue>10</issue>), <fpage>e1003779</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pmed.1003779</pub-id>
<pub-id pub-id-type="pmid">34637450</pub-id>
</mixed-citation>
</ref>
<ref id="B15">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gu</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Yu</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Zhang</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Yu</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Sha</surname>
<given-names>W.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>The effectiveness of group counselling in reducing loneliness among elderly people in nursing homes: a randomised controlled study</article-title>. <source>Contemp. Nurses Low. Decade</source> <volume>26</volume> (<issue>7</issue>), <fpage>109</fpage>&#x2013;<lpage>111</lpage>. <comment>(in Chinese)</comment>.</mixed-citation>
</ref>
<ref id="B16">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Hawkley</surname>
<given-names>L. C.</given-names>
</name>
<name>
<surname>Kocherginsky</surname>
<given-names>M. J. R. o. a.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Transitions in loneliness among older adults: a 5-year follow-up in the national Social Life</article-title>. <source>Health, Aging Proj.</source> <volume>40</volume> (<issue>4</issue>), <fpage>365</fpage>&#x2013;<lpage>387</lpage>. <pub-id pub-id-type="doi">10.1177/0164027517698965</pub-id>
<pub-id pub-id-type="pmid">29519211</pub-id>
</mixed-citation>
</ref>
<ref id="B18">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Hutton</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Salanti</surname>
<given-names>G.</given-names>
</name>
<name>
<surname>Caldwell</surname>
<given-names>D. M.</given-names>
</name>
<name>
<surname>Chaimani</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Schmid</surname>
<given-names>C. H.</given-names>
</name>
<name>
<surname>Cameron</surname>
<given-names>C.</given-names>
</name>
<etal/>
</person-group> (<year>2015</year>). <article-title>The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations</article-title>. <source>Ann. Intern. Med.</source> <volume>162</volume> (<issue>11</issue>), <fpage>777</fpage>&#x2013;<lpage>784</lpage>. <pub-id pub-id-type="doi">10.7326/M14-2385</pub-id>
<pub-id pub-id-type="pmid">26030634</pub-id>
</mixed-citation>
</ref>
<ref id="B19">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ibarra</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Baez</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Cernuzzi</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Casati</surname>
<given-names>F.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>A systematic review on technology-supported interventions to improve old-age social wellbeing: loneliness, social isolation, and connectedness</article-title>. <source>J. Healthc. Eng.</source> <volume>2020</volume>, <fpage>2036842</fpage>. <comment>Article 2036842</comment>. <pub-id pub-id-type="doi">10.1155/2020/2036842</pub-id>
<pub-id pub-id-type="pmid">32765823</pub-id>
</mixed-citation>
</ref>
<ref id="B20">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ilgaz</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>G&#xf6;z&#xfc;m</surname>
<given-names>S. J. A. C.</given-names>
</name>
<name>
<surname>Research</surname>
<given-names>E.</given-names>
</name>
</person-group> (<year>2023</year>). <article-title>Effectiveness of INOSEL program consisting of Integrative Nursing and Omaha System for older women feeling loneliness: a randomised controlled trial</article-title>. <volume>35</volume>(<issue>11</issue>), <fpage>2769</fpage>&#x2013;<lpage>2781</lpage>.<pub-id pub-id-type="pmid">37759148</pub-id>
</mixed-citation>
</ref>
<ref id="B21">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Jin</surname>
<given-names>W.</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Yuan</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Bai</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Bai</surname>
<given-names>Z. J. F. i. P.</given-names>
</name>
</person-group> (<year>2021</year>). <article-title>The effectiveness of technology-based interventions for reducing loneliness in older adults: a systematic review and meta-analysis of randomized controlled trials</article-title>. <source>Front. Psychol.</source> <volume>12</volume>, <fpage>711030</fpage>. <pub-id pub-id-type="doi">10.3389/fpsyg.2021.711030</pub-id>
<pub-id pub-id-type="pmid">34955948</pub-id>
</mixed-citation>
</ref>
<ref id="B48">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Jos&#x00E9;</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Luis &#x00C1;ngel</surname>
<given-names>P. T.</given-names>
</name>
<name>
<surname>Manuel</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Josefa</surname>
<given-names>G.</given-names>
</name>
<name>
<surname>Juan</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Jer&#x00F3;nimo</surname>
<given-names>G.</given-names>
</name>
</person-group> (<year>2022</year>). <article-title>Effectiveness of a multicomponent intervention to reduce social isolation and loneliness in community&#x2010;dwelling elders: A randomized clinical trial</article-title>. <source>Nurs. Open</source> <volume>10</volume> (<issue>1</issue>), <fpage>48</fpage>&#x2013;<lpage>60</lpage>. <pub-id pub-id-type="doi">10.1002/NOP2.1277</pub-id>
<pub-id pub-id-type="pmid">35751180</pub-id>
</mixed-citation>
</ref>
<ref id="B22">
<mixed-citation publication-type="book">
<person-group person-group-type="author">
<name>
<surname>Kassim</surname>
<given-names>S. N. A. b.</given-names>
</name>
<name>
<surname>Ahmad Badayai</surname>
<given-names>A. R.</given-names>
</name>
</person-group> (<year>2023</year>). <source>Social support and coping strategies as mediators in the relationship between feeling of loneliness and mental health</source>. <publisher-name>International Journal of Academic Research in Business and Social Sciences</publisher-name>.</mixed-citation>
</ref>
<ref id="B23">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kremers</surname>
<given-names>I. P.</given-names>
</name>
<name>
<surname>Steverink</surname>
<given-names>N.</given-names>
</name>
<name>
<surname>Albersnagel</surname>
<given-names>F. A.</given-names>
</name>
<name>
<surname>Slaets</surname>
<given-names>J. P.</given-names>
</name>
</person-group> (<year>2006</year>). <article-title>Improved self-management ability and well-being in older women after a short group intervention</article-title>. <source>Aging &#x26; Mental Health</source> <volume>10</volume> (<issue>5</issue>), <fpage>476</fpage>&#x2013;<lpage>484</lpage>. <pub-id pub-id-type="doi">10.1080/13607860600841206</pub-id>
<pub-id pub-id-type="pmid">16938683</pub-id>
</mixed-citation>
</ref>
<ref id="B24">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Lai</surname>
<given-names>D. W. L.</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Ou</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>C. Y. P.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Effectiveness of a peer-based intervention on loneliness and social isolation of older Chinese immigrants in Canada: a randomized controlled trial journal Article; Randomized controlled Trial</article-title>. <source>BMC Geriatrics</source> <volume>20</volume> (<issue>1</issue>), <fpage>356</fpage>. <pub-id pub-id-type="doi">10.1186/s12877-020-01756-9</pub-id>
<pub-id pub-id-type="pmid">32958076</pub-id>
</mixed-citation>
</ref>
<ref id="B25">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Lampinen</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Conradsson</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Nyqvist</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Olofsson</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Gustafson</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Nilsson</surname>
<given-names>I.</given-names>
</name>
<etal/>
</person-group> (<year>2022</year>). <article-title>Loneliness among very old people with and without dementia: prevalence and associated factors in a representative sample</article-title>. <source>Eur. J. Ageing</source> <volume>19</volume> (<issue>4</issue>), <fpage>1441</fpage>&#x2013;<lpage>1453</lpage>. <pub-id pub-id-type="doi">10.1007/s10433-022-00729-8</pub-id>
<pub-id pub-id-type="pmid">36157280</pub-id>
</mixed-citation>
</ref>
<ref id="B26">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Lapane</surname>
<given-names>K. L.</given-names>
</name>
<name>
<surname>Lim</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>McPhillips</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Barooah</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Yuan</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Dube</surname>
<given-names>C. E. J. A. o. G.</given-names>
</name>
</person-group> (<year>2022</year>). <article-title>Health effects of loneliness and social isolation in older adults living in congregate long term care settings: a systematic review of quantitative and qualitative evidence</article-title>, <source>Arch. Gerontol. Geriatr.</source> <volume>102</volume>, <fpage>104728</fpage>, <pub-id pub-id-type="doi">10.1016/j.archger.2022.104728</pub-id>
<pub-id pub-id-type="pmid">35597183</pub-id>
</mixed-citation>
</ref>
<ref id="B27">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Larsson</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Padyab</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Larsson-Lund</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Nilsson</surname>
<given-names>I.</given-names>
</name>
</person-group> (<year>2016</year>). <article-title>Effects of a social internet-based intervention programme for older adults: an explorative randomised crossover study</article-title>. <source>Br. J. Occup. Ther.</source> <volume>79</volume> (<issue>10</issue>), <fpage>629</fpage>&#x2013;<lpage>636</lpage>. <pub-id pub-id-type="doi">10.1177/0308022616641701</pub-id>
</mixed-citation>
</ref>
<ref id="B28">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ma</surname>
<given-names>R. M.</given-names>
</name>
<name>
<surname>Mann</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>J. Y.</given-names>
</name>
<name>
<surname>Lloyd-Evans</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Terhune</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Al-Shihabi</surname>
<given-names>A.</given-names>
</name>
<etal/>
</person-group> (<year>2020</year>). <article-title>The effectiveness of interventions for reducing subjective and objective social isolation among people with mental health problems: a systematic review</article-title>. <source>Soc. Psychiatry Psychiatric Epidemiology</source> <volume>55</volume> (<issue>7</issue>), <fpage>839</fpage>&#x2013;<lpage>876</lpage>. <pub-id pub-id-type="doi">10.1007/s00127-019-01800-z</pub-id>
<pub-id pub-id-type="pmid">31741017</pub-id>
</mixed-citation>
</ref>
<ref id="B29">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Manzanares</surname>
<given-names>O.</given-names>
</name>
<name>
<surname>Tran</surname>
<given-names>Q. D.</given-names>
</name>
<name>
<surname>Le Breton</surname>
<given-names>J. J. R. M. S.</given-names>
</name>
</person-group> (<year>2021</year>). <article-title>Social isolation and loneliness among old people during Covid-19 pandemic</article-title>. <source>Rev. Med. Suisse</source> <volume>17</volume> (<issue>757</issue>), <fpage>1878</fpage>&#x2013;<lpage>1882</lpage>.<pub-id pub-id-type="pmid">34738762</pub-id>
</mixed-citation>
</ref>
<ref id="B30">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Munn</surname>
<given-names>Z.</given-names>
</name>
<name>
<surname>Barker</surname>
<given-names>T. H.</given-names>
</name>
<name>
<surname>Moola</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Tufanaru</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Stern</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>McArthur</surname>
<given-names>A.</given-names>
</name>
<etal/>
</person-group> (<year>2020</year>). <article-title>Methodological quality of case series studies: an introduction to the JBI critical appraisal tool</article-title>. <source>JBI Evid. Synth.</source> <volume>18</volume> (<issue>10</issue>), <fpage>2127</fpage>&#x2013;<lpage>2133</lpage>. <pub-id pub-id-type="doi">10.11124/JBISRIR-D-19-00099</pub-id>
<pub-id pub-id-type="pmid">32813462</pub-id>
</mixed-citation>
</ref>
<ref id="B31">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Noone</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>McSharry</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Smalle</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Burns</surname>
<given-names>A.</given-names>
</name>
<name>
<surname>Dwan</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>Devane</surname>
<given-names>D.</given-names>
</name>
<etal/>
</person-group> (<year>2020</year>). <article-title>Video calls for reducing social isolation and loneliness in older people: a rapid review</article-title>. <source>Cochrane Database Syst. Rev.</source> <volume>5</volume> (<issue>5</issue>), <fpage>CD013632</fpage>. <pub-id pub-id-type="doi">10.1002/14651858.CD013632</pub-id>
<pub-id pub-id-type="pmid">32441330</pub-id>
</mixed-citation>
</ref>
<ref id="B32">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>O&#x27;Rourke</surname>
<given-names>H. M.</given-names>
</name>
<name>
<surname>Collins</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Sidani</surname>
<given-names>S.</given-names>
</name>
</person-group> (<year>2018</year>). <article-title>Interventions to address social connectedness and loneliness for older adults: a scoping review</article-title>. <source>BMC Geriatrics</source> <volume>18</volume>, <fpage>214</fpage>. <pub-id pub-id-type="doi">10.1186/s12877-018-0897-x</pub-id>
<pub-id pub-id-type="pmid">30219034</pub-id>
</mixed-citation>
</ref>
<ref id="B33">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Perissinotto</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Holt&#x2010;Lunstad</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Periyakoil</surname>
<given-names>V. S.</given-names>
</name>
<name>
<surname>Covinsky</surname>
<given-names>K. J. J. o. t. A. G. S.</given-names>
</name>
</person-group> (<year>2019</year>). <article-title>A practical approach to assessing and mitigating loneliness and isolation in older adults</article-title>. <source>J. Am. Geriatr. Soc.</source> <volume>67</volume> (<issue>4</issue>), <fpage>657</fpage>&#x2013;<lpage>662</lpage>. <pub-id pub-id-type="doi">10.1111/jgs.15746</pub-id>
<pub-id pub-id-type="pmid">30762228</pub-id>
</mixed-citation>
</ref>
<ref id="B34">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Petersen</surname>
<given-names>N.</given-names>
</name>
<name>
<surname>K&#xf6;nig</surname>
<given-names>H.-H.</given-names>
</name>
<name>
<surname>Hajek</surname>
<given-names>A. J. A. o. g.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>The link between falls, social isolation and loneliness</article-title>. <source>A Systematic Review</source> <volume>88</volume>, <fpage>104020</fpage>. <pub-id pub-id-type="doi">10.1016/j.archger.2020.104020</pub-id>
<pub-id pub-id-type="pmid">32018091</pub-id>
</mixed-citation>
</ref>
<ref id="B35">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Quan</surname>
<given-names>N. G.</given-names>
</name>
<name>
<surname>Lohman</surname>
<given-names>M. C.</given-names>
</name>
<name>
<surname>Resciniti</surname>
<given-names>N. V.</given-names>
</name>
<name>
<surname>Friedman</surname>
<given-names>D. B. J. A.</given-names>
</name>
<name>
<surname>health</surname>
<given-names>m.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>A systematic review of interventions for loneliness among older adults living in long-term care facilities</article-title>. <source>Aging Ment. Health</source> <volume>24</volume> (<issue>12</issue>), <fpage>1945</fpage>&#x2013;<lpage>1955</lpage>. <pub-id pub-id-type="doi">10.1080/13607863.2019.1673311</pub-id>
<pub-id pub-id-type="pmid">31602993</pub-id>
</mixed-citation>
</ref>
<ref id="B36">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ristolainen</surname>
<given-names>H.</given-names>
</name>
<name>
<surname>Kannasoja</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Tiilikainen</surname>
<given-names>E.</given-names>
</name>
<name>
<surname>Hakala</surname>
<given-names>M.</given-names>
</name>
<name>
<surname>Narhi</surname>
<given-names>K.</given-names>
</name>
<name>
<surname>Rissanen</surname>
<given-names>S.</given-names>
</name>
</person-group> (<year>2020</year>). <article-title>Effects of ?participatory group -based care management? On wellbeing of older people living alone: a randomized controlled trial</article-title>. <source>Archives Gerontology Geriatrics</source> <volume>89</volume>, <fpage>104095</fpage>. <pub-id pub-id-type="doi">10.1016/j.archger.2020.104095</pub-id>
<pub-id pub-id-type="pmid">32446172</pub-id>
</mixed-citation>
</ref>
<ref id="B37">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Rodr&#xed;guez-Romero</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Herranz-Rodr&#xed;guez</surname>
<given-names>C.</given-names>
</name>
<name>
<surname>Kostov</surname>
<given-names>B.</given-names>
</name>
<name>
<surname>Gen&#xe9;-Badia</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Sis&#xf3;-Almirall</surname>
<given-names>A.</given-names>
</name>
</person-group> (<year>2021</year>). <article-title>Intervention to reduce perceived loneliness in community-dwelling older people</article-title>. <source>Scand. Journal Caring Sciences</source> <volume>35</volume> (<issue>2</issue>), <fpage>366</fpage>&#x2013;<lpage>374</lpage>. <pub-id pub-id-type="doi">10.1111/scs.12852</pub-id>
<pub-id pub-id-type="pmid">32285499</pub-id>
</mixed-citation>
</ref>
<ref id="B38">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Saito</surname>
<given-names>T.</given-names>
</name>
<name>
<surname>Kai</surname>
<given-names>I.</given-names>
</name>
<name>
<surname>Takizawa</surname>
<given-names>A.</given-names>
</name>
</person-group> (<year>2012</year>). <article-title>Effects of a program to prevent social isolation on loneliness, depression, and subjective well-being of older adults: a randomized trial among older migrants in Japan</article-title>. <source>Archives Gerontology Geriatrics</source> <volume>55</volume> (<issue>3</issue>), <fpage>539</fpage>&#x2013;<lpage>547</lpage>. <pub-id pub-id-type="doi">10.1016/j.archger.2012.04.002</pub-id>
<pub-id pub-id-type="pmid">22564362</pub-id>
</mixed-citation>
</ref>
<ref id="B39">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Timmermans</surname>
<given-names>E. J.</given-names>
</name>
<name>
<surname>Hoogendijk</surname>
<given-names>E. O.</given-names>
</name>
<name>
<surname>Broese van Groenou</surname>
<given-names>M. I.</given-names>
</name>
<name>
<surname>Comijs</surname>
<given-names>H. C.</given-names>
</name>
<name>
<surname>van Schoor</surname>
<given-names>N. M.</given-names>
</name>
<name>
<surname>Thom&#xe9;se</surname>
<given-names>F. C.</given-names>
</name>
<etal/>
</person-group> (<year>2019</year>). <article-title>Trends across 20 years in multiple indicators of functioning among older adults in the Netherlands</article-title>. <source>Eur. J. Public Health</source> <volume>29</volume> (<issue>6</issue>), <fpage>1096</fpage>&#x2013;<lpage>1102</lpage>. <pub-id pub-id-type="doi">10.1093/eurpub/ckz065</pub-id>
<pub-id pub-id-type="pmid">31008512</pub-id>
</mixed-citation>
</ref>
<ref id="B40">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Tkatch</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Wu</surname>
<given-names>L. Z.</given-names>
</name>
<name>
<surname>MacLeod</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Ungar</surname>
<given-names>R.</given-names>
</name>
<name>
<surname>Albright</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Russell</surname>
<given-names>D.</given-names>
</name>
<etal/>
</person-group> (<year>2021</year>). <article-title>Reducing loneliness and improving well-being among older adults with animatronic pets</article-title>. <source>Aging &#x26; Mental Health</source> <volume>25</volume> (<issue>7</issue>), <fpage>1239</fpage>&#x2013;<lpage>1245</lpage>. <pub-id pub-id-type="doi">10.1080/13607863.2020.1758906</pub-id>
<pub-id pub-id-type="pmid">32363903</pub-id>
</mixed-citation>
</ref>
<ref id="B41">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wang</surname>
<given-names>P.</given-names>
</name>
<name>
<surname>Cui</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Zhao</surname>
<given-names>W.</given-names>
</name>
<name>
<surname>Duan</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>D.</given-names>
</name>
</person-group> (<year>2014</year>). <article-title>Loneliness in older adults and its intervention effect of group counselling</article-title>. <source>Chin. J. Health Psychol.</source> <volume>9</volume>, <fpage>1398</fpage>&#x2013;<lpage>1400</lpage>. <pub-id pub-id-type="doi">10.13342/j.cnki.cjhp.2014.09.047</pub-id>
</mixed-citation>
</ref>
<ref id="B42">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wang</surname>
<given-names>Y.</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Yao</surname>
<given-names>L.</given-names>
</name>
<name>
<surname>Ren</surname>
<given-names>T.</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>T. J. B. o.</given-names>
</name>
</person-group> (<year>2023</year>). <article-title>Effectiveness of social support programmes on loneliness in community-dwelling older adults: study protocol for a meta-analysis of randomised controlled trials</article-title>. <source>BMJ Open</source> <volume>13</volume> (<issue>12</issue>), <fpage>e073739</fpage>. <pub-id pub-id-type="doi">10.1136/bmjopen-2023-073739</pub-id>
<pub-id pub-id-type="pmid">38072487</pub-id>
</mixed-citation>
</ref>
<ref id="B43">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wei</surname>
<given-names>D.</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Deng</surname>
<given-names>S.</given-names>
</name>
<name>
<surname>Yan</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>C.</given-names>
</name>
</person-group> (<year>2021</year>). <article-title>Relationship between social media use and older adults&#x27; loneliness and social support and interventions</article-title>. <source>Chin. J. Gerontology</source> <volume>41</volume> (<issue>20</issue>), <fpage>4584</fpage>&#x2013;<lpage>4587</lpage>. <pub-id pub-id-type="doi">10.3969/j.issn.1005-9202.2021.20.066</pub-id>
</mixed-citation>
</ref>
<ref id="B44">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Yang</surname>
<given-names>S. Y.</given-names>
</name>
<name>
<surname>Yang</surname>
<given-names>C. C.</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>Y. C.</given-names>
</name>
<name>
<surname>Hsieh</surname>
<given-names>P. L.</given-names>
</name>
<name>
<surname>Lin</surname>
<given-names>Y. L. J. G.</given-names>
</name>
<name>
<surname>International</surname>
<given-names>G.</given-names>
</name>
</person-group> (<year>2023</year>). <article-title>Investigating the effectiveness of online interactive courses on loneliness and quality of life of older adults in the community during the COVID&#x2010;19 pandemic</article-title>. <source>A Pilot Study a Randomized Controlled Trial</source> <volume>23</volume> (<issue>2</issue>), <fpage>91</fpage>&#x2013;<lpage>97</lpage>. <pub-id pub-id-type="doi">10.1111/ggi.14526</pub-id>
<pub-id pub-id-type="pmid">36573632</pub-id>
</mixed-citation>
</ref>
<ref id="B45">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Yu</surname>
<given-names>K. X.</given-names>
</name>
<name>
<surname>Wu</surname>
<given-names>S. Y.</given-names>
</name>
<name>
<surname>Jang</surname>
<given-names>Y. R.</given-names>
</name>
<name>
<surname>Chou</surname>
<given-names>C. P.</given-names>
</name>
<name>
<surname>Wilber</surname>
<given-names>K. H.</given-names>
</name>
<name>
<surname>Aranda</surname>
<given-names>M. P.</given-names>
</name>
<etal/>
</person-group> (<year>2021</year>). <article-title>Longitudinal assessment of the relationships between geriatric conditions and loneliness</article-title>. <source>J. Am. Med. Dir. Assoc.</source>, <volume>22</volume>(<issue>5</issue>), <fpage>1107</fpage>&#x2013;<lpage>1113.e1</lpage>. <pub-id pub-id-type="doi">10.1016/j.jamda.2020.09.002</pub-id>
<pub-id pub-id-type="pmid">33071157</pub-id>
</mixed-citation>
</ref>
<ref id="B46">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Zhang</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Dong</surname>
<given-names>S. J. A. P.</given-names>
</name>
</person-group> (<year>2022</year>). <article-title>The relationships between social support and loneliness: a meta-analysis and review</article-title>, <source>Acta Psychol.</source> <volume>227</volume>, <fpage>103616</fpage>, <pub-id pub-id-type="doi">10.1016/j.actpsy.2022.103616</pub-id>
<pub-id pub-id-type="pmid">35576818</pub-id>
</mixed-citation>
</ref>
<ref id="B47">
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Zhou</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Yang</surname>
<given-names>J.</given-names>
</name>
<name>
<surname>Qiang</surname>
<given-names>F.</given-names>
</name>
<name>
<surname>Ma</surname>
<given-names>X.</given-names>
</name>
<name>
<surname>Guo</surname>
<given-names>Q.</given-names>
</name>
</person-group> (<year>2014</year>). <article-title>Study on the effect of family doctor service on the intervention of empty nesters in the community</article-title>. <source>China Natl. Fam. Med.</source> (<issue>16</issue>), <fpage>1845</fpage>&#x2013;<lpage>1850</lpage>. <pub-id pub-id-type="doi">10.3969/j.issn.1007-9572.2014.16.011</pub-id>
</mixed-citation>
</ref>
</ref-list>
</back>
</article>